技术领域technical field
本发明涉及一种电子领域，尤其涉及一种蓝光刺激丘脑前核的方法及装置。 The invention relates to the field of electronics, in particular to a method and device for stimulating the anterior nucleus of the thalamus with blue light. the
背景技术Background technique
呼吸是一种节律运动，现阶段研究认为呼吸节律是通过呼吸中枢呼吸神经细胞群的产生，参与呼吸节律的调节与改善，共同实现机体的正常呼吸运动。由于器官损伤如心肺衰竭、气管堵塞、气胸、脑压过高对二氧化碳敏感度降低等多种可能原因，呼吸节律受到破坏，出现浅而快呼吸、过深过慢呼吸、呼吸暂停、潮式呼吸、叹息样呼吸等，会导致呼吸性酸中毒、碱中毒、呼吸停止死亡等严重后果。其中，药物作用反应慢，而且并不能提前预防和实时调控呼吸；一些物理手段如呼吸机等只能暂时改善呼吸状况，而且便携性差；应用较为广泛的膈肌起搏虽然具有实时监测和调控的功能，但是呼吸中枢过度兴奋导致呼吸短促导致的呼吸性酸中毒，还有叹息样呼吸都不在膈肌起搏器的作用的范围之内。此外，持续刺激膈神经可能导致膈肌疲劳，呼吸通气量减少，仍然会造成呼吸通气不足，对于改善呼吸状况并不理想。 Breathing is a kind of rhythmic movement. At present, the study believes that the breathing rhythm is produced by the respiratory nerve cell group in the respiratory center, participates in the regulation and improvement of the breathing rhythm, and realizes the normal breathing movement of the body together. Due to organ damage such as heart and lung failure, tracheal blockage, pneumothorax, high cerebral pressure and reduced sensitivity to carbon dioxide, etc., the respiratory rhythm is damaged, and shallow and fast breathing, deep and slow breathing, apnea, tidal breathing, Sighing breathing, etc., can lead to serious consequences such as respiratory acidosis, alkalosis, respiratory arrest and death. Among them, the response of drugs is slow, and it cannot prevent and control breathing in advance; some physical means such as ventilators can only temporarily improve breathing conditions, and their portability is poor; although the widely used diaphragm pacing has the function of real-time monitoring and regulation , but respiratory acidosis caused by shortness of breath caused by over-excitement of the respiratory center, and sigh-like breathing are not within the scope of action of the diaphragm pacemaker. In addition, continuous stimulation of the phrenic nerve may lead to fatigue of the diaphragm, reduced respiratory ventilation, and still cause hypoventilation, which is not ideal for improving respiratory conditions. the
发明内容Contents of the invention
本发明实施例所要解决的技术问题在于，提供一种蓝光刺激丘脑前核的方法及装置。可以通过蓝光刺激使神经纤维产生兴奋以调节呼吸状态，不会导致膈肌疲劳，调控呼吸状态更为精确有效。 The technical problem to be solved by the embodiments of the present invention is to provide a method and device for stimulating the anterior nucleus of the thalamus with blue light. The nerve fibers can be stimulated by blue light to adjust the breathing state, which will not cause fatigue of the diaphragm, and the control of the breathing state is more precise and effective. the
为了解决上述技术问题，本发明实施例提供了一种蓝光刺激丘脑前核的方法，包括： In order to solve the above technical problems, an embodiment of the present invention provides a method for stimulating the anterior nucleus of the thalamus with blue light, including:
通过红光和红外光交替照射人体表面分别获取被人体组织吸收后的红光的反射光信号和红外光的反射光信号； By alternately irradiating the surface of the human body with red light and infrared light, the reflected light signal of red light and the reflected light signal of infrared light absorbed by human tissue are respectively obtained;
根据获取到的所述红光的反射光信号和所述红外光的反射光信号计算血氧饱和度，根据计算得到的所述血氧饱和度计算氧分压； Calculate the blood oxygen saturation according to the acquired reflected light signal of the red light and the reflected light signal of the infrared light, and calculate the partial pressure of oxygen according to the calculated blood oxygen saturation;
根据计算得到的所述氧分压，发射对应频率的蓝光刺激丘脑前核的GABA能神经纤维。 According to the calculated partial pressure of oxygen, blue light of corresponding frequency is emitted to stimulate the GABAergic nerve fibers of the anterior nucleus of the thalamus. the
其中，所述根据获取到的所述红光的反射光信号和所述红外光的反射光信号计算血氧饱和度包括：将获取到的所述红光的反射光信号和所述红外光的反射光信号进行滤波放大处理，并转换成红光的电压信号和红外光的电压信号；将转换得到的所述红光的电压信号和所述红外光的电压信号转化为红光的数字电压信号和红外光的数字电压信号；根据转化得到的所述红光的数字电压信号和所述红外光的数字电压信号计算所述血氧饱和度。 Wherein, the calculating the blood oxygen saturation according to the acquired reflected light signal of the red light and the reflected light signal of the infrared light includes: combining the acquired reflected light signal of the red light and the reflected light signal of the infrared light The reflected light signal is filtered and amplified, and converted into a voltage signal of red light and a voltage signal of infrared light; the converted voltage signal of red light and the voltage signal of infrared light are converted into a digital voltage signal of red light and the digital voltage signal of the infrared light; the blood oxygen saturation is calculated according to the converted digital voltage signal of the red light and the digital voltage signal of the infrared light. the
其中，所述开启蓝光刺激丘脑前核的GABA能神经纤维之前包括：将光敏感离子通道蛋白的基因ChR2注射到丘脑前核，使得在所述丘脑前核的GABA能神经纤维内表达光敏感离子通道蛋白。 Wherein, before turning on the blue light to stimulate the GABAergic nerve fibers of the anterior nucleus of the thalamus, it includes: injecting the gene ChR2 of the light-sensitive ion channel protein into the anterior nucleus of the thalamus, so that light-sensitive ions are expressed in the GABAergic nerve fibers of the anterior nucleus of the thalamus channel protein. the
其中，所述根据计算得到的所述氧分压，发射对应频率的蓝光刺激丘脑前核的GABA能神经纤维包括：若计算得到的所述氧分压超过预设阀值，则发射20HZ频率的蓝光刺激所述丘脑前核的GABA能神经纤维。 Wherein, according to the calculated partial pressure of oxygen, emitting blue light of a corresponding frequency to stimulate the GABAergic nerve fibers of the anterior nucleus of the thalamus includes: if the calculated partial pressure of oxygen exceeds a preset threshold value, then emitting blue light with a frequency of 20HZ Blue light stimulates GABAergic nerve fibers in the anterior nucleus of the thalamus. the
其中，所述若计算得到的所述氧分压超过预设阀值，则发射20HZ频率的蓝光刺激所述丘脑前核的GABA能神经纤维之前还包括：对氧分压进行采样，根据采样获取到的氧分压计算出所述氧分压的均值、标准差或方差；根据计算得到的均值、标准差或方差设定所述预设阀值。 Wherein, if the calculated partial pressure of oxygen exceeds the preset threshold value, before emitting blue light with a frequency of 20 Hz to stimulate the GABAergic nerve fibers of the anterior nucleus of the thalamus, it also includes: sampling the partial pressure of oxygen, and obtaining Calculate the mean value, standard deviation or variance of the oxygen partial pressure from the calculated oxygen partial pressure; set the preset threshold according to the calculated mean value, standard deviation or variance. the
相应地，本发明实施例还提供了一种蓝光刺激丘脑前核的装置，包括： Correspondingly, an embodiment of the present invention also provides a device for stimulating the anterior nucleus of the thalamus with blue light, including:
反射光获取模块，用于通过红光和红外光交替照射人体表面分别获取被人体组织吸收后的红光的反射光信号和红外光的反射光信号； The reflected light acquisition module is used to alternately irradiate the human body surface with red light and infrared light to obtain the reflected light signal of red light and the reflected light signal of infrared light absorbed by human tissue respectively;
氧分压计算模块，用于根据获取到的所述红光的反射光信号和所述红外光的反射光信号计算血氧饱和度，根据计算得到的所述血氧饱和度计算氧分压； An oxygen partial pressure calculation module, configured to calculate blood oxygen saturation according to the acquired reflected light signal of the red light and the reflected light signal of the infrared light, and calculate the oxygen partial pressure according to the calculated blood oxygen saturation;
蓝光发射模块，用于根据计算得到的所述氧分压，发射对应频率的蓝光刺激丘脑前核的GABA能神经纤维。 The blue light emission module is used to emit blue light of a corresponding frequency to stimulate the GABAergic nerve fibers of the anterior nucleus of the thalamus according to the calculated oxygen partial pressure. the
其中，所述氧分压计算模块包括：反射光处理单元，用于将获取到的所述红光的反射光信号和所述红外光的反射光信号进行滤波放大处理，并转换成红光的电压信号和红外光的电压信号；电压信号处理单元，用于将转换得到的所述红光的电压信号和所述红外光的电压信号转化为红光的数字电压信号和红外光的数字电压信号；饱和度计算单元，用于根据转化得到的所述红光的数字电 压信号和所述红外光的数字电压信号计算所述血氧饱和度。 Wherein, the oxygen partial pressure calculation module includes: a reflected light processing unit, configured to filter and amplify the acquired reflected light signals of the red light and the reflected light signals of the infrared light, and convert them into red light signals. The voltage signal and the voltage signal of infrared light; the voltage signal processing unit is used to convert the converted voltage signal of red light and the voltage signal of infrared light into a digital voltage signal of red light and a digital voltage signal of infrared light The saturation calculation unit is used to calculate the blood oxygen saturation according to the converted digital voltage signal of the red light and the digital voltage signal of the infrared light. the
其中，所述装置还包括：基因注射模块，用于将光敏感离子通道蛋白的基因ChR2注射到丘脑前核，使得在所述丘脑前核的GABA能神经纤维内表达光敏感离子通道蛋白。 Wherein, the device further includes: a gene injection module, which is used to inject the gene ChR2 of the light-sensitive ion channel protein into the anterior nucleus of the thalamus, so that the light-sensitive ion channel protein is expressed in the GABAergic nerve fibers of the anterior nucleus of the thalamus. the
其中，所述蓝光发射模块包括：判定发射单元，用于若计算得到的所述氧分压超过预设阀值，则发射20HZ频率的蓝光刺激所述丘脑前核的GABA能神经纤维。 Wherein, the blue light emission module includes: a determination emission unit, configured to emit blue light with a frequency of 20 Hz to stimulate the GABAergic nerve fibers of the anterior nucleus of the thalamus if the calculated partial pressure of oxygen exceeds a preset threshold. the
其中，所述蓝光发射模块还包括：采样计算单元，用于对氧分压进行采样，根据采样获取到的氧分压计算出氧分压的均值、标准差或方差；阀值设定单元，用于根据计算得到的均值、标准差或方差设定所述预设阀值。 Wherein, the blue light emission module further includes: a sampling calculation unit for sampling the partial pressure of oxygen, and calculating the mean value, standard deviation or variance of the partial pressure of oxygen according to the partial pressure of oxygen obtained by sampling; a threshold setting unit, It is used to set the preset threshold according to the calculated mean, standard deviation or variance. the
实施本发明实施例，具有如下有益效果：通过红光和红外光交替照射人体表面分别获取被人体组织吸收后的红光的反射光信号和红外光的反射光信号，并根据获取到的所述红光的反射光信号和所述红外光的反射光信号计算血氧饱和度，若根据血氧饱和度计算得到的氧分压超出预设阀值，则发射对应频率的蓝光刺激丘脑前核的GABA能神经纤维。通过蓝光刺激丘脑前核的GABA能神经纤维不会导致膈肌疲劳，调控呼吸状态更为精确有效。 Implementing the embodiment of the present invention has the following beneficial effects: by alternately irradiating the surface of the human body with red light and infrared light, the reflected light signal of red light and the reflected light signal of infrared light absorbed by human tissue are respectively obtained, and according to the obtained The reflected light signal of the red light and the reflected light signal of the infrared light are used to calculate the blood oxygen saturation. If the partial pressure of oxygen calculated according to the blood oxygen saturation exceeds the preset threshold, blue light of the corresponding frequency is emitted to stimulate the anterior nucleus of the thalamus. GABAergic nerve fibers. Stimulating the GABAergic nerve fibers of the anterior nucleus of the thalamus with blue light will not cause fatigue of the diaphragm, and the regulation of the respiratory state is more precise and effective. the
附图说明Description of drawings
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。 In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only These are some embodiments of the present invention. Those skilled in the art can also obtain other drawings based on these drawings without creative work. the
图1是本发明实施例提供的蓝光刺激丘脑前核的方法流程图； Fig. 1 is the method flowchart of blue light stimulation anterior nucleus of thalamus provided by the embodiment of the present invention;
图2是本发明实施例提供的用于蓝光刺激丘脑前核的装置的结构示意图； Fig. 2 is a schematic structural view of a device for stimulating the anterior nucleus of the thalamus with blue light provided by an embodiment of the present invention;
图3是本发明实施例装置中氧分压计算模块的结构示意图； Fig. 3 is the structural representation of the oxygen partial pressure calculation module in the device of the embodiment of the present invention;
图4是本发明实施例装置中蓝光发射模块的结构示意图。 Fig. 4 is a schematic structural diagram of a blue light emitting module in a device according to an embodiment of the present invention. the
具体实施方式Detailed ways
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清 楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。 The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention. the
图1是本发明实施例提供的蓝光刺激丘脑前核的方法流程图，本发明实施例提供了一种实时检测氧分压，并根据检测到的氧分压发射对应蓝光刺激丘脑前核的方法，如图所示所述蓝光刺激丘脑前核的方法包括： Figure 1 is a flow chart of the method for stimulating the anterior nucleus of the thalamus with blue light according to an embodiment of the present invention. The embodiment of the present invention provides a method for detecting the partial pressure of oxygen in real time and emitting corresponding blue light according to the detected partial pressure of oxygen to stimulate the anterior nucleus of the thalamus , as shown in the figure, the method of stimulating the anterior nucleus of the thalamus with blue light includes:
步骤S110，通过红光和红外光交替照射人体表面分别获取被人体组织吸收后的红光的反射光信号和红外光的反射光信号。具体实现中，光通过组织和血管时，非动脉成份（如皮肤、肌肉、骨骼、静脉血等）吸收光信号是恒定的，经过光电接收器后得到直流分量DC；动脉成分（如动脉血）对光信号的吸收是随着脉搏搏动作周期性变化，经过光电接收器后得到交流分量AC。血液中的血红蛋白对红光和蓝光有不同的吸收率，所述血红蛋白包括氧合血红蛋白HbO2和还原血红蛋白Hb，氧合血红蛋白HbO2对660nm红光吸收量较少，对940nm红外光吸收量较多；还原血红蛋白Hb则对660nm红光吸收量较多，对940nm红外光吸收量较少。因此交替发射红光和红外光，可以获得红光的反射光直流信号和交流信号，同时可以获得红外光的反射光直流信号和交流信号，并且由于血红蛋白对红光和蓝光的吸收率不同，所以获取得到的所述红光的交流分量是主要是被还原血红蛋白Hb吸收后的反射光，获取得到的所述红外光的交流分量是主要是被氧合血红蛋白HbO2吸收后的反射光。 Step S110 , alternately irradiating the surface of the human body with red light and infrared light to acquire reflected light signals of red light and infrared light absorbed by human tissue respectively. In specific implementation, when light passes through tissues and blood vessels, non-arterial components (such as skin, muscle, bone, venous blood, etc.) absorb light signals that are constant, and obtain DC components after passing through photoelectric receivers; arterial components (such as arterial blood) The absorption of the light signal changes periodically with the pulse action, and the AC component AC is obtained after passing through the photoelectric receiver. Hemoglobin in the blood has different absorption rates for red light and blue light. Said hemoglobin includes oxyhemoglobin HbO2 and reduced hemoglobin Hb. Reduced hemoglobin Hb absorbs more 660nm red light and less absorbs 940nm infrared light. Therefore, red light and infrared light are alternately emitted, and the reflected light DC signal and AC signal of red light can be obtained. At the same time, the reflected light DC signal and AC signal of infrared light can be obtained, and because hemoglobin has different absorption rates for red light and blue light, so The acquired AC component of the red light is mainly reflected light absorbed by reduced hemoglobin Hb, and the acquired AC component of the infrared light is mainly reflected light absorbed by oxyhemoglobin HbO2 .
步骤S120，根据获取到的所述红光的反射光信号和所述红外光的反射光信号计算血氧饱和度，根据计算得到的所述血氧饱和度计算氧分压。在计算血氧饱和度之前，需要对获取到的所述红光的反射光信号和所述红外光的反射光信号进行处理。具体实现中，首先通过光电转换器将获取到的所述红光的反射光信号和所述红外光的反射光信号转化为红光的电流信号和红外光的电流信号，然后通过电流电压转化电路将该电流信号转换成红光的电压信号和红外光的电压信号，并对所述红光的电压信号和红外光的电压信号进行过滤放大处理，最后通过AD转换电路将所述红光的电压信号和所述红外光的电压信号转化为红光的数字电压信号和红外光的数字电压信号，同时通过交直流分离电路将其处理为红光和红外光的直流分量和交流分量。所述红光的数字电压信号包括红光的直流分量Vrdc和交流信号Vrac，所述红外光的数字电压信号包括红外光的直 流分量Virdc和交流信号Virac。 Step S120, calculating the blood oxygen saturation according to the acquired reflected light signal of the red light and the reflected light signal of the infrared light, and calculating the partial pressure of oxygen according to the calculated blood oxygen saturation. Before calculating the blood oxygen saturation, it is necessary to process the acquired reflected light signal of the red light and the reflected light signal of the infrared light. In the specific implementation, the acquired reflected light signal of the red light and the reflected light signal of the infrared light obtained are first converted into a current signal of red light and a current signal of infrared light through a photoelectric converter, and then through a current-voltage conversion circuit Convert the current signal into a voltage signal of red light and a voltage signal of infrared light, and filter and amplify the voltage signal of red light and voltage signal of infrared light, and finally convert the voltage of red light to The signal and the voltage signal of the infrared light are converted into a digital voltage signal of the red light and a digital voltage signal of the infrared light, and are processed into a DC component and an AC component of the red light and the infrared light through an AC-DC separation circuit at the same time. The digital voltage signal of the red light includes the DC component Vrdc of the red light and the AC signal Vrac, and the digital voltage signal of the infrared light includes the DC component Virdc of the infrared light and the AC signal Virac. the
根据转化得到的所述红光的数字电压信号和所述红外光的数字电压信号计算所述血氧饱和度。具体实现中，红光的光强在人体组织中吸收率可以表示为交流信号Vrac与直流分量Vrdc的比值，红外光的光强在人体组织中吸收率可以表示为交流信号Virac与直流分量Virdc的比值，根据红光和红外光在人体组织中吸收率可以计算得到血红蛋白对红光和红外光的光吸收比率R，所述光吸收比率R可以表示为：R=(Vrac/Vrdc)/(Virac/Virdc)。 The blood oxygen saturation is calculated according to the converted digital voltage signal of the red light and the digital voltage signal of the infrared light. In a specific implementation, the absorption rate of the light intensity of red light in human tissue can be expressed as the ratio of the AC signal Vrac to the DC component Vrdc, and the absorption rate of the infrared light intensity in human tissue can be expressed as the ratio of the AC signal Virac to the DC component Virdc Ratio, according to the absorption rate of red light and infrared light in human tissue, the light absorption ratio R of hemoglobin to red light and infrared light can be calculated, and the light absorption ratio R can be expressed as: R=(Vrac/Vrdc)/(Virac /Virdc). the
根据所述光吸收比率R便可以计算出两种血红蛋白含量的百分比。血氧饱和度的计算公式如下： The percentages of the two hemoglobin contents can be calculated according to the light absorption ratio R. The formula for calculating blood oxygen saturation is as follows:
sp02=A—BR+CR2，（2表示R的平方）式中，A、B、C为定标常数，可以由定标实验得到。 sp02 =A—BR+CR2 , (2 represents the square of R) In the formula, A, B, and C are calibration constants, which can be obtained from calibration experiments.
在计算得到血氧饱和度之后，根据氧离曲线或氧分压与氧饱和度曲线即可计算出当前大脑的氧分压，所述氧离曲线反映的是血氧饱和度和氧分压之间的关系，纵坐标轴为血氧饱和度，横坐标轴为氧分压，可以通过氧离曲线中的血氧饱和度和氧分压的对应关系得到氧分压。 After the blood oxygen saturation is calculated, the current oxygen partial pressure of the brain can be calculated according to the oxygen dissociation curve or the oxygen partial pressure and oxygen saturation curve. The oxygen dissociation curve reflects the relationship between blood oxygen saturation and oxygen partial pressure. The relationship between blood oxygen saturation on the axis of ordinate and partial pressure of oxygen on the axis of abscissa. The oxygen partial pressure can be obtained through the corresponding relationship between blood oxygen saturation and oxygen partial pressure in the oxygen dissociation curve. the
步骤S130，根据计算得到的所述氧分压，发射对应频率的蓝光刺激丘脑前核的GABA能神经纤维。发射蓝光刺激丘脑前核的GABA能神经纤维之前，需要将光敏感离子通道蛋白的基因ChR2注射到丘脑前核，使得在所述丘脑前核的GABA能神经纤维内表达光敏感离子通道蛋白。具体实现中，若步骤S120计算得到的所述氧分压超出预设阀值，则发射20HZ频率的蓝光刺激所述丘脑前核的GABA能神经纤维。在通过蓝光刺激丘脑前核的过程中，需要同时开启红光和红外光照射人体表面以实时检测大脑的血氧饱和度，当检测到大脑的血氧饱和度恢复到正常状态时，则停止发射蓝光刺激丘脑前核的GABA能神经纤维。其中，红光和红外光是以200HZ的发射频率照射人体表面，蓝光是以20HZ发射频率刺激丘脑前核的GABA能神经纤维。 Step S130, according to the calculated partial pressure of oxygen, emit blue light of a corresponding frequency to stimulate GABAergic nerve fibers in the anterior nucleus of the thalamus. Before emitting blue light to stimulate the GABAergic nerve fibers of the anterior nucleus of the thalamus, the gene ChR2 of the light-sensitive ion channel protein needs to be injected into the anterior nucleus of the thalamus, so that the light-sensitive ion channel protein is expressed in the GABAergic nerve fibers of the anterior nucleus of the thalamus. In a specific implementation, if the partial pressure of oxygen calculated in step S120 exceeds the preset threshold value, blue light with a frequency of 20 Hz is emitted to stimulate the GABAergic nerve fibers of the anterior nucleus of the thalamus. In the process of stimulating the anterior nucleus of the thalamus with blue light, it is necessary to simultaneously turn on red light and infrared light to illuminate the surface of the human body to detect the blood oxygen saturation of the brain in real time. When it is detected that the blood oxygen saturation of the brain returns to a normal state, the emission is stopped. Blue light stimulates GABAergic nerve fibers in the anterior nucleus of the thalamus. Among them, the red light and infrared light irradiate the surface of the human body with the emission frequency of 200HZ, and the blue light stimulates the GABAergic nerve fibers of the anterior nucleus of the thalamus with the emission frequency of 20HZ. the
其中，步骤S130还包括对氧分压进行采样，根据采样获取到的氧分压计算出氧分压的均值、标准差或方差，根据计算得到的均值、标准差或方差设定所述预设阀值。氧分压正常范围为95～100mmHg，但该值会随着年龄的增长而降低。同时地域差异性大，不同地区正常值范围不同，目前国内大部分地区常用正常值范围80～100mmHg，高原地区较低，一般为60～80mmHg。血氧饱和度一 般94%以下认定为缺氧状态，临床上以90%为界限进行判定。为了针对不同人身体情况的不同，在设定预设阀值时，需要对氧分压进行实时采样，之后进行统计分析，算出氧分压的均值、标准差或方差等统计参数，依据参数设定氧分压的预设阈值，如设定3倍标准差为预设阀值，当检测到所述氧分压超过该预设阀值时，即视该氧分压处于不正常状态。特别的，本发明实施例可以直接利用血氧饱和度作为参数进行阀值设置和反馈。 Wherein, step S130 also includes sampling the partial pressure of oxygen, calculating the mean value, standard deviation or variance of the partial pressure of oxygen according to the partial pressure of oxygen obtained by sampling, and setting the preset value according to the calculated mean value, standard deviation or variance. threshold. The normal range of oxygen partial pressure is 95 ~ 100mmHg, but this value will decrease with age. At the same time, there are large regional differences, and the range of normal values in different regions is different. At present, the normal range of normal values in most areas of China is 80-100 mmHg, and the range of normal values in plateau areas is lower, generally 60-80 mmHg. Blood oxygen saturation below 94% is generally considered to be in a hypoxic state, and clinically 90% is used as the limit for judgment. In order to meet the different physical conditions of different people, when setting the preset threshold, it is necessary to sample the partial pressure of oxygen in real time, and then perform statistical analysis to calculate the statistical parameters such as the mean value, standard deviation or variance of the partial pressure of oxygen. As for the preset threshold of the fixed oxygen partial pressure, if 3 times the standard deviation is set as the preset threshold, when it is detected that the oxygen partial pressure exceeds the preset threshold, the oxygen partial pressure is considered to be in an abnormal state. In particular, the embodiment of the present invention can directly use blood oxygen saturation as a parameter to perform threshold setting and feedback. the
可选的，通过直接注射携带有细胞特异启动子和编码光敏感离子通道蛋白的核酸序列的慢病毒载体，可将光敏感离子通道蛋白的基因ChR2送至丘脑前核，使其在丘脑前核的GABA能神经纤维内表达。ChR2蛋白是一种视紫红质，起源于单细胞类绿藻莱茵衣藻。研究发现，ChR2基因编码光激活型离子通道蛋白，该蛋白受到蓝光刺激时，将打开离子通道，使得细胞电位去极化兴奋，产生动作电位。通过生物技术，可在哺乳类动物组织细胞膜表面表达该蛋白，表达该蛋白基因的细胞受到472nm波长的蓝光刺激时，可使胞外阳离子内流而使细胞去极化，兴奋细胞活性。而该波长的光对脑中其它神经元正常功能并没有影响，不会带来其它副作用。 Optionally, by directly injecting a lentiviral vector carrying a cell-specific promoter and a nucleic acid sequence encoding a light-sensitive ion channel protein, the gene ChR2 of the light-sensitive ion channel protein can be sent to the anterior nucleus of the thalamus, so that it can be expressed in the anterior nucleus of the thalamus. Expression of GABAergic nerve fibers. The ChR2 protein is a rhodopsin that originates from the unicellular green alga Chlamydomonas reinhardtii. Studies have found that the ChR2 gene encodes a light-activated ion channel protein. When the protein is stimulated by blue light, it will open the ion channel, depolarize and excite the cell potential, and generate an action potential. Through biotechnology, the protein can be expressed on the cell membrane surface of mammalian tissues. When the cells expressing the protein gene are stimulated by blue light with a wavelength of 472nm, extracellular cations can flow in to depolarize the cells and stimulate cell activity. The light of this wavelength has no effect on the normal function of other neurons in the brain, and will not bring other side effects. the
可选的，本发明实施例中处理数字电压信号、计算血氧饱和、控制发射红外光和红光、蓝光可以采用MICROCHIP推出的体积非常小的PIC10F系列单片机，该单片机配备4MHz精确内置振荡器、33条指令、两层堆栈、25毫安输入/输出电流I/O、低功耗备用电流(100纳安)、由2至5.5V的宽操作电压范围、一个8位时钟、监测时钟(Watchdog Timer)。该单片机中有3个具有独立方向控制功能的I/O管脚，可采用其中两个I/O口控制红光和红外光的开启与关闭，一个I/O控制蓝光的开启与关闭，还有一个输入管脚，接收经过处理过的红光和红外光的数字电压信号。其中，光频率的调控采用单片机中4MHz精确内置振荡器进行定时调控。 Optionally, in the embodiment of the present invention, processing digital voltage signals, calculating blood oxygen saturation, and controlling emission of infrared light, red light, and blue light can use the very small PIC10F series single-chip microcomputer launched by MICROCHIP. The single-chip microcomputer is equipped with a 4MHz precise built-in oscillator, 33 instructions, two-level stack, 25 mA input/output current I/O, low power standby current (100 nA), wide operating voltage range from 2 to 5.5 V, an 8-bit clock, watchdog clock (Watchdog Timer). There are 3 I/O pins with independent direction control function in the single chip microcomputer. Two of the I/O ports can be used to control the opening and closing of red light and infrared light, and one I/O can be used to control the opening and closing of blue light. There is an input pin that receives processed digital voltage signals of red and infrared light. Among them, the regulation of the optical frequency adopts the 4MHz precise built-in oscillator in the single chip microcomputer for timing regulation. the
图2是本发明实施例提供的用于蓝光刺激丘脑前核的装置的结构示意图。所述光刺激丘脑前核的装置包括：反射光获取模块210、氧分压计算模块220以及蓝光发射模块230，其中： Fig. 2 is a schematic structural diagram of a device for stimulating the anterior nucleus of the thalamus with blue light provided by an embodiment of the present invention. The device for stimulating the anterior nucleus of the thalamus with light includes: a reflected light acquisition module 210, an oxygen partial pressure calculation module 220, and a blue light emission module 230, wherein:
反射光获取模块210，用于通过红光和红外光交替照射人体表面分别获取被人体组织吸收后的红光的反射光信号和红外光的反射光信号。具体的，光通过组织和血管时，非动脉成份（如皮肤、肌肉、骨骼、静脉血等）吸收光信号是 恒定的，经过光电接收器后得到直流分量DC；动脉成分（如动脉血）对光信号的吸收是随着脉搏搏动作周期性变化，经过光电接收器后得到交流分量AC。血液中的血红蛋白对红光和蓝光有不同的吸收率，所述血红蛋白包括氧合血红蛋白HbO2和还原血红蛋白Hb，氧合血红蛋白HbO2对660nm红光吸收量较少，对940nm红外光吸收量较多；还原血红蛋白Hb则对660nm红光吸收量较多，对940nm红外光吸收量较少。因此交替发射红光和红外光，可以获得红光的发射光直流信号和交流信号，同时可以获得红外光的发射光直流信号和交流信号，并且由于血红蛋白对红光和蓝光的吸收率不同，所以获取得到的所述红光的交流分量是主要是被还原血红蛋白Hb吸收后的反射光，获取得到的所述红外光的交流分量是主要是被氧合血红蛋白HbO2吸收后的反射光。 The reflected light acquisition module 210 is configured to alternately irradiate the surface of the human body with red light and infrared light to acquire reflected light signals of red light and infrared light absorbed by human tissue respectively. Specifically, when light passes through tissues and blood vessels, non-arterial components (such as skin, muscle, bone, venous blood, etc.) absorb light signals that are constant, and obtain DC components after passing through photoelectric receivers; arterial components (such as arterial blood) The absorption of the optical signal changes periodically with the pulse action, and the AC component AC is obtained after passing through the photoelectric receiver. Hemoglobin in the blood has different absorption rates for red light and blue light. Said hemoglobin includes oxyhemoglobin HbO2 and reduced hemoglobin Hb. Reduced hemoglobin Hb absorbs more 660nm red light and less absorbs 940nm infrared light. Therefore, by alternately emitting red light and infrared light, the direct current signal and alternating current signal of red light emission can be obtained, and the direct current signal and alternating current signal of infrared light emission can be obtained at the same time, and because hemoglobin has different absorption rates for red light and blue light, so The acquired AC component of the red light is mainly reflected light absorbed by reduced hemoglobin Hb, and the acquired AC component of the infrared light is mainly reflected light absorbed by oxyhemoglobin HbO2 .
氧分压计算模块220，用于根据反射光获取模块210获取到的所述红光的反射光信号和所述红外光的反射光信号计算血氧饱和度，根据计算得到的所述血氧饱和度计算氧分压。在计算血氧饱和度之前，需要对获取到的所述红光的反射光信号和所述红外光的反射光信号进行处理。所述氧分压计算模块220包括：反射光处理单元321、电压信号处理单元322以及饱和度计算单元323，其中： The oxygen partial pressure calculation module 220 is configured to calculate the blood oxygen saturation according to the reflected light signal of the red light and the reflected light signal of the infrared light acquired by the reflected light acquisition module 210, and calculate the blood oxygen saturation according to the calculated blood oxygen saturation Calculate the partial pressure of oxygen. Before calculating the blood oxygen saturation, it is necessary to process the acquired reflected light signal of the red light and the reflected light signal of the infrared light. The oxygen partial pressure calculation module 220 includes: a reflected light processing unit 321, a voltage signal processing unit 322, and a saturation calculation unit 323, wherein:
反射光处理单元321，用于将反射光获取模块210获取到的所述红光的反射光信号和所述红外光的反射光信号进行滤波放大处理，并转换成红光的电压信号和红外光的电压信号。具体的，首先通过光电转换器将所述红光的反射光信号和所述红外光的反射光信号转化为红光的电流信号和红外光的电流信号，然后通过电流电压转化电路将该电流信号转换成红光的电压信号和红外光的电压信号，最后通过滤波放大电路对所述红光的电压信号和红外光的电压信号进行过滤放大处理。 The reflected light processing unit 321 is configured to filter and amplify the reflected light signal of the red light and the reflected light signal of the infrared light acquired by the reflected light acquisition module 210, and convert it into a voltage signal of red light and an infrared light signal. voltage signal. Specifically, the reflected light signal of the red light and the reflected light signal of the infrared light are first converted into a current signal of the red light and a current signal of the infrared light through a photoelectric converter, and then the current signal is passed through a current-voltage conversion circuit It is converted into a voltage signal of red light and a voltage signal of infrared light, and finally the voltage signal of red light and the voltage signal of infrared light are filtered and amplified by a filter amplifier circuit. the
电压信号处理单元322，用于将反射光处理单元321转换得到的所述红光的电压信号和所述红外光的电压信号转化为红光的数字电压信号和红外光的数字电压信号。具体的，可以通过AD转换电路将所述红光的电压信号和所述红外光的电压信号转化为红光的数字电压信号和红外光的数字电压信号，同时通过交直流分离电路处理为红光和红外光的直流分量和交流分量。 The voltage signal processing unit 322 is configured to convert the voltage signal of the red light and the voltage signal of the infrared light converted by the reflected light processing unit 321 into a digital voltage signal of red light and a digital voltage signal of infrared light. Specifically, the voltage signal of the red light and the voltage signal of the infrared light can be converted into a digital voltage signal of red light and a digital voltage signal of infrared light through an AD conversion circuit, and processed into red light through an AC-DC separation circuit and the DC and AC components of infrared light. the
饱和度计算单元323，用于根据电压信号处理单元322转化得到的所述红光的数字电压信号和所述红外光的数字电压信号计算所述血氧饱和度。所述红光的数字电压信号包括红光的直流分量Vrdc和交流信号Vrac，所述红外光的数字 电压信号包括红外光的直流分量Virdc和交流信号Virac。具体的，红光的光强在人体组织中吸收率可以表示为交流信号Vrac与直流分量Vrdc的比值，红外光的光强在人体组织中吸收率可以表示为交流信号Virac与直流分量Virdc的比值，根据红光和红外光在人体组织中吸收率可以计算得到血红蛋白对红光和红外光的光吸收比率R，所述光吸收比率R可以表示为： The saturation calculation unit 323 is configured to calculate the blood oxygen saturation according to the digital voltage signal of the red light and the digital voltage signal of the infrared light converted by the voltage signal processing unit 322 . The digital voltage signal of the red light includes the DC component Vrdc and the AC signal Vrac of the red light, and the digital voltage signal of the infrared light includes the DC component Virdc and the AC signal Virac of the infrared light. Specifically, the absorption rate of red light intensity in human tissue can be expressed as the ratio of AC signal Vrac to DC component Vrdc, and the absorption rate of infrared light intensity in human tissue can be expressed as the ratio of AC signal Virac to DC component Virdc , according to the absorption rate of red light and infrared light in human tissue, the light absorption ratio R of hemoglobin to red light and infrared light can be calculated, and the light absorption ratio R can be expressed as:
R=(Vrac/Vrdc)/(Virac/Virdc) R=(Vrac/Vrdc)/(Virac/Virdc)
根据所述光吸收比率R便可以计算出两种血红蛋白含量的百分比。血氧饱和度的计算公式如下： The percentages of the two hemoglobin contents can be calculated according to the light absorption ratio R. The formula for calculating blood oxygen saturation is as follows:
sp02=A—BR+CR2，（2表示R的平方）式中，A、B、C为定标常数，可以由定标实验得到。 sp02 =A—BR+CR2 , (2 represents the square of R) In the formula, A, B, and C are calibration constants, which can be obtained from calibration experiments.
在计算得到血氧饱和度之后，根据氧离曲线或氧分压与氧饱和度曲线即可计算出当前大脑的氧分压，所述氧离曲线反映的是血氧饱和度和氧分压之间的关系，纵坐标轴为血氧饱和度，横坐标轴为氧分压，可以通过氧离曲线中的血氧饱和度和氧分压的对应关系得到氧分压。 After the blood oxygen saturation is calculated, the current oxygen partial pressure of the brain can be calculated according to the oxygen dissociation curve or the oxygen partial pressure and oxygen saturation curve. The oxygen dissociation curve reflects the relationship between blood oxygen saturation and oxygen partial pressure. The relationship between blood oxygen saturation on the axis of ordinate and partial pressure of oxygen on the axis of abscissa. The oxygen partial pressure can be obtained through the corresponding relationship between blood oxygen saturation and oxygen partial pressure in the oxygen dissociation curve. the
蓝光发射模块230，用于根据氧分压计算模块220计算得到的所述氧分压，发射对应频率的蓝光刺激丘脑前核的GABA能神经纤维。发射蓝光刺激丘脑前核的GABA能神经纤维之前，需要将光敏感离子通道蛋白的基因ChR2注射到丘脑前核，使得在所述丘脑前核的GABA能神经纤维内表达光敏感离子通道蛋白。具体的，若氧分压计算模块220计算得到的所述氧分压超出预设阀值，则发射20HZ频率的蓝光刺激所述丘脑前核的GABA能神经纤维。在通过蓝光刺激丘脑前核的过程中，需要同时发射红光和红外光照射人体表面以实时检测大脑的血氧饱和度，当检测到大脑的血氧饱和度恢复到正常状态时，则停止发射蓝光刺激丘脑前核的GABA能神经纤维。其中，红光和红外光是以200HZ的发射频率照射人体表面，蓝光是以20HZ发射频率刺激丘脑前核的GABA能神经纤维。 The blue light emitting module 230 is configured to emit blue light of a corresponding frequency to stimulate the GABAergic nerve fibers of the anterior nucleus of the thalamus according to the oxygen partial pressure calculated by the oxygen partial pressure calculation module 220 . Before emitting blue light to stimulate the GABAergic nerve fibers of the anterior nucleus of the thalamus, the gene ChR2 of the light-sensitive ion channel protein needs to be injected into the anterior nucleus of the thalamus, so that the light-sensitive ion channel protein is expressed in the GABAergic nerve fibers of the anterior nucleus of the thalamus. Specifically, if the partial pressure of oxygen calculated by the partial pressure of oxygen calculation module 220 exceeds the preset threshold value, blue light with a frequency of 20 Hz is emitted to stimulate the GABAergic nerve fibers of the anterior nucleus of the thalamus. In the process of stimulating the anterior nucleus of the thalamus with blue light, it is necessary to simultaneously emit red light and infrared light to illuminate the surface of the human body to detect the blood oxygen saturation of the brain in real time. When it is detected that the blood oxygen saturation of the brain returns to a normal state, the emission is stopped. Blue light stimulates GABAergic nerve fibers in the anterior nucleus of the thalamus. Among them, the red light and infrared light irradiate the surface of the human body with the emission frequency of 200HZ, and the blue light stimulates the GABAergic nerve fibers of the anterior nucleus of the thalamus with the emission frequency of 20HZ. the
所述蓝光发射模块230还包括如图4所示的采样计算单元431以及阀值设定单元432，其中： The blue light emitting module 230 also includes a sampling calculation unit 431 and a threshold setting unit 432 as shown in FIG. 4, wherein:
采样计算单元431，用于对氧分压进行采样，根据采样获取到的氧分压计算出氧分压的均值、标准差或方差。具体的，氧分压正常范围为95～100mmHg，但该值会随着年龄的增长而降低。同时地域差异性大，不同地区正常值范围不 同，目前国内大部分地区常用正常值范围80～100mmHg，高原地区较低，一般为60～80mmHg。血氧饱和度一般94%以下认定为缺氧状态，临床上以90%为界限进行判定。为了针对不同人身体情况的不同，在设定预设阀值时，需要对氧分压进行实时采样，之后进行统计分析，算出所述氧分压的均值、标准差或方差等统计参数。 The sampling calculation unit 431 is configured to sample the partial pressure of oxygen, and calculate the mean value, standard deviation or variance of the partial pressure of oxygen according to the partial pressure of oxygen obtained by sampling. Specifically, the normal range of partial pressure of oxygen is 95-100 mmHg, but this value will decrease with age. At the same time, there are large regional differences, and the range of normal values in different regions is different. At present, the normal range of normal values in most areas of China is 80-100 mmHg, and the range of normal values in plateau areas is lower, generally 60-80 mmHg. Blood oxygen saturation below 94% is generally considered to be in a hypoxic state, and clinically 90% is used as the limit for judgment. In order to address the different physical conditions of different people, when setting the preset threshold, real-time sampling of the partial pressure of oxygen is required, and then statistical analysis is performed to calculate statistical parameters such as the mean value, standard deviation or variance of the partial pressure of oxygen. the
阀值设定单元432，用于根据采样计算单元431计算得到的所述氧分压的均值、标准差或方差设定所述预设阀值。例如设定3倍标准差为预设阀值，当检测到所述氧分压超过该预设阀值时，即视该氧分压处于不正常状态。 The threshold value setting unit 432 is configured to set the preset threshold value according to the mean value, standard deviation or variance of the oxygen partial pressure calculated by the sampling calculation unit 431 . For example, 3 times the standard deviation is set as the preset threshold value, and when it is detected that the oxygen partial pressure exceeds the preset threshold value, the oxygen partial pressure is deemed to be in an abnormal state. the
可选的，通过直接注射携带有细胞特异启动子和编码光敏感离子通道蛋白的核酸序列的慢病毒载体，可将光敏感离子通道蛋白的基因ChR2送至丘脑前核，使其在丘脑前核的GABA能神经纤维内表达。ChR2蛋白是一种视紫红质，起源于单细胞类绿藻莱茵衣藻。研究发现，ChR2基因编码光激活型离子通道蛋白，该蛋白受到蓝光刺激时，将打开离子通道，使得细胞电位去极化兴奋，产生动作电位。通过生物技术，可在哺乳类动物组织细胞膜表面表达该蛋白，表达该蛋白基因的细胞受到472nm波长的蓝光刺激时，可使胞外阳离子内流而使细胞去极化，兴奋细胞活性。而该波长的光对脑中其它神经元正常功能并没有影响，不会带来其它副作用。 Optionally, by directly injecting a lentiviral vector carrying a cell-specific promoter and a nucleic acid sequence encoding a light-sensitive ion channel protein, the gene ChR2 of the light-sensitive ion channel protein can be sent to the anterior nucleus of the thalamus, so that it can be expressed in the anterior nucleus of the thalamus. Expression of GABAergic nerve fibers. The ChR2 protein is a rhodopsin that originates from the unicellular green alga Chlamydomonas reinhardtii. Studies have found that the ChR2 gene encodes a light-activated ion channel protein. When the protein is stimulated by blue light, it will open the ion channel, depolarize and excite the cell potential, and generate an action potential. Through biotechnology, the protein can be expressed on the cell membrane surface of mammalian tissues. When the cells expressing the protein gene are stimulated by blue light with a wavelength of 472nm, extracellular cations can flow in to depolarize the cells and stimulate cell activity. The light of this wavelength has no effect on the normal function of other neurons in the brain, and will not bring other side effects. the
可选的，本发明实施例中处理数字电压信号、计算血氧饱和、控制发射红外光和红光、蓝光可以采用MICROCHIP推出的体积非常小的PIC10F系列单片机，该单片机配备4MHz精确内置振荡器、33条指令、两层堆栈、25毫安输入/输出电流I/O、低功耗备用电流(100纳安)、由2至5.5V的宽操作电压范围、一个8位时钟、监测时钟(Watchdog Timer)。该单片机中有3个具有独立方向控制功能的I/O管脚，可采用其中两个I/O口控制红光和红外光的开启与关闭，一个I/O控制蓝光的开启与关闭，还有一个输入管脚，接收经过处理过的红光和红外光的数字电压信号。其中，光频率的调控采用单片机中4MHz精确内置振荡器进行定时调控。 Optionally, in the embodiment of the present invention, processing digital voltage signals, calculating blood oxygen saturation, and controlling emission of infrared light, red light, and blue light can use the very small PIC10F series single-chip microcomputer launched by MICROCHIP. The single-chip microcomputer is equipped with a 4MHz precise built-in oscillator, 33 instructions, two-level stack, 25 mA input/output current I/O, low power standby current (100 nA), wide operating voltage range from 2 to 5.5 V, an 8-bit clock, watchdog clock (Watchdog Timer). There are 3 I/O pins with independent direction control function in the single chip microcomputer. Two of the I/O ports can be used to control the opening and closing of red light and infrared light, and one I/O can be used to control the opening and closing of blue light. There is an input pin that receives processed digital voltage signals of red and infrared light. Among them, the regulation of the optical frequency adopts the 4MHz precise built-in oscillator in the single chip microcomputer for timing regulation. the
本发明实施例提供了一种蓝光刺激丘脑前核的方法及装置，通过红光和红外光交替照射人体表面分别获取被人体组织吸收后的红光的反射光信号和红外光的反射光信号，并根据获取到的所述红光的反射光信号和所述红外光的反射光信号计算血氧饱和度，若根据血氧饱和度计算得到的氧分压超出预设阀值， 则发射对应频率的蓝光刺激丘脑前核的GABA能神经纤维。通过蓝光刺激丘脑前核的GABA能神经纤维不会导致膈肌疲劳，调控呼吸状态更为精确有效。 The embodiment of the present invention provides a method and device for stimulating the anterior nucleus of the thalamus with blue light, which alternately irradiates the surface of the human body with red light and infrared light to obtain the reflected light signal of red light and the reflected light signal of infrared light absorbed by human tissue respectively, And calculate the blood oxygen saturation according to the obtained reflected light signal of the red light and the reflected light signal of the infrared light, if the partial pressure of oxygen calculated according to the blood oxygen saturation exceeds the preset threshold value, then transmit the corresponding frequency The blue light stimulates GABAergic nerve fibers in the anterior nucleus of the thalamus. Stimulating the GABAergic nerve fibers of the anterior nucleus of the thalamus with blue light will not cause fatigue of the diaphragm, and the regulation of the respiratory state is more precise and effective. the
本领域普通技术人员可以理解实现上述实施例方法中的全部或部分流程，是可以通过计算机程序来指令相关的硬件来完成，所述的程序可存储于一计算机可读取存储介质中，该程序在执行时，可包括如上述各方法的实施例的流程。其中，所述的存储介质可为磁碟、光盘、只读存储记忆体（Read-Only Memory，ROM）或随机存储记忆体（Random Access Memory，RAM）等。 Those of ordinary skill in the art can understand that all or part of the processes in the methods of the above embodiments can be implemented through computer programs to instruct related hardware, and the programs can be stored in a computer-readable storage medium. During execution, it may include the processes of the embodiments of the above-mentioned methods. Wherein, the storage medium may be a magnetic disk, an optical disk, a read-only memory (Read-Only Memory, ROM) or a random access memory (Random Access Memory, RAM), etc. the
以上所揭露的仅为本发明较佳实施例而已，当然不能以此来限定本发明之权利范围，因此依本发明权利要求所作的等同变化，仍属本发明所涵盖的范围 。The above disclosures are only preferred embodiments of the present invention, and certainly cannot limit the scope of rights of the present invention. Therefore, equivalent changes made according to the claims of the present invention still fall within the scope of the present invention.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310699854.9ACN104721964B (en) | 2013-12-18 | 2013-12-18 | Method and device for stimulating anterior thalamic nucleus by blue light |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310699854.9ACN104721964B (en) | 2013-12-18 | 2013-12-18 | Method and device for stimulating anterior thalamic nucleus by blue light |
| Publication Number | Publication Date |
|---|---|
| CN104721964Atrue CN104721964A (en) | 2015-06-24 |
| CN104721964B CN104721964B (en) | 2017-05-10 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310699854.9AActiveCN104721964B (en) | 2013-12-18 | 2013-12-18 | Method and device for stimulating anterior thalamic nucleus by blue light |
| Country | Link |
|---|---|
| CN (1) | CN104721964B (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107582034A (en)* | 2017-10-16 | 2018-01-16 | 陕西特恩电子科技有限公司 | A kind of physiological parameter tester |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5353790A (en)* | 1992-01-17 | 1994-10-11 | Board Of Regents, The University Of Texas System | Method and apparatus for optical measurement of bilirubin in tissue |
| US20070016269A1 (en)* | 2005-07-12 | 2007-01-18 | Shuhei Suzuki | Beauty device |
| CN201404597Y (en)* | 2009-05-31 | 2010-02-17 | 徐州安诺休闲设备有限公司 | Far infrared dry steaming foot bath barrel |
| CN202821367U (en)* | 2012-10-25 | 2013-03-27 | 北京超思电子技术股份有限公司 | Multi-functional blood oxygen instrument |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5353790A (en)* | 1992-01-17 | 1994-10-11 | Board Of Regents, The University Of Texas System | Method and apparatus for optical measurement of bilirubin in tissue |
| US20070016269A1 (en)* | 2005-07-12 | 2007-01-18 | Shuhei Suzuki | Beauty device |
| CN201404597Y (en)* | 2009-05-31 | 2010-02-17 | 徐州安诺休闲设备有限公司 | Far infrared dry steaming foot bath barrel |
| CN202821367U (en)* | 2012-10-25 | 2013-03-27 | 北京超思电子技术股份有限公司 | Multi-functional blood oxygen instrument |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107582034A (en)* | 2017-10-16 | 2018-01-16 | 陕西特恩电子科技有限公司 | A kind of physiological parameter tester |
| Publication number | Publication date |
|---|---|
| CN104721964B (en) | 2017-05-10 |
| Publication | Publication Date | Title |
|---|---|---|
| CN101496767B (en) | External cardiac massage rhythm prompting device and method thereof | |
| US8764674B2 (en) | Heart sound monitoring of pulmonary hypertension | |
| EP2859913B1 (en) | Pulse oximetry-based Cardio-Pulmonary Resuscitation (CPR) quality feedback systems and methods | |
| US20160317385A1 (en) | Automatic chest compression systems that incorporate biological feedback | |
| CN103857371A (en) | Coordinated resuscitation perfusion support | |
| CN107041838A (en) | CPR Quality Feedback Control system based on pulse blood oxygen | |
| Wu et al. | Adjunctive therapeutic effects of cinnamomum camphora forest environment on elderly patients with hypertension | |
| EP3001951A1 (en) | Method and system for measuring oxyhemoglobin saturation in blood | |
| Li et al. | Electrocardiogram waveforms for monitoring effectiveness of chest compression during cardiopulmonary resuscitation | |
| WO2019023093A1 (en) | Systems and methods for disambiguation of posture | |
| TW202337392A (en) | Method for automatically controlling gas flow output flow of hydrogen production equipment | |
| CN104721964B (en) | Method and device for stimulating anterior thalamic nucleus by blue light | |
| CN216908583U (en) | Intelligent cardiopulmonary resuscitation machine | |
| Dow et al. | EMG-based detection of inspiration in the rat diaphragm muscle | |
| Kirkman | Respiration: control of ventilation | |
| CN104721832A (en) | Applications of expression vector carrying light-sensing ion channel protein encoding gene in preparation of respiratory rhythm regulating and controlling drug | |
| Wei et al. | Detection of spontaneous pulse using the acceleration signals acquired from CPR feedback sensor in a porcine model of cardiac arrest | |
| Sun et al. | Optimizing the duration of CPR prior to defibrillation improves the outcome of CPR in a rat model of prolonged cardiac arrest | |
| CN202409868U (en) | Laser therapeutic apparatus for irradiating nasal cavity | |
| RU2315553C1 (en) | Method for decreasing the increased functional activity of thrombocytes in vivo in an experiment | |
| CN108685654A (en) | Near-infrared oxygenation treatment tank | |
| Hopster et al. | Resuscitation attempts in a foal with sudden cardiac arrest in the early recovery period | |
| CN104721833A (en) | Respiratory rhythm regulation medicine, and preparation method and application thereof | |
| Shi et al. | Automated pupillometry helps monitor the efficacy of cardiopulmonary resuscitation and predict return of spontaneous circulation | |
| CN207679825U (en) | A kind of bionical expectoration lung ventilator of diaphram stimulation |
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | Effective date of registration:20220629 Address after:518000 A-301, office building, Shenzhen Institute of advanced technology, No. 1068, Xue Yuan Avenue, Shenzhen University Town, Shenzhen, Guangdong, Nanshan District, China Patentee after:Shenzhen shen-tech advanced Cci Capital Ltd. Address before:1068 No. 518055 Guangdong city in Shenzhen Province, Nanshan District City Xili University School Avenue Patentee before:SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY Effective date of registration:20220629 Address after:518118 innovation Plaza a2402, No. 2007, Pingshan Avenue, Liulian community, Pingshan street, Pingshan District, Shenzhen, Guangdong Patentee after:Shenzhen comparative Medical Technology Co.,Ltd. Address before:518000 A-301, office building, Shenzhen Institute of advanced technology, No. 1068, Xue Yuan Avenue, Shenzhen University Town, Shenzhen, Guangdong, Nanshan District, China Patentee before:Shenzhen shen-tech advanced Cci Capital Ltd. | |
| TR01 | Transfer of patent right |