A kind of Bionics Bone girder lumbar fusion cages and preparation method thereofTechnical field
The present invention relates to human spine's lumbar surgery and merge apparatus, particularly relate to a kind of Bionics Bone girder lumbar fusion cages and preparation method thereof.
Background technology
Tradition intervertebral fusion apparatus adopts macromolecular material or metal material machining to form, and can only play the effect of physical support in human body, but exists and can not grow into by induced osteogenesis, can not reach the technological deficiency improving spinal fusion rate.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Bionics Bone girder lumbar fusion cages and preparation method thereof, overcome the shortcoming of prior art, the present invention adopts 3D printing technique, bionical in microstructure, can grow into by induced osteogenesis, reach the effect improving spinal fusion rate.
Technical problem to be solved by this invention is achieved through the following technical solutions:
A kind of Bionics Bone girder lumbar fusion cages, comprises the overall trabecular bone structure of fusion device support column, filling slot, tapered tip portion, manual imitation bone structure formation;
Described trabecular bone structure is provided with rear connecting portion.
Described filling slot is filled with spongy bone and bone; Described Grafting Cancellous Bone Bolt girder is graininess.
Described fusion device support column has the effect supporting and fill, and described filling slot is for filling spongy bone and bone; Described tapered tip portion is conducive to squeezing into vertebral body position; Described manual imitation bone structure is the structure after filling; The rear end entity of described rear connecting portion, for connecting holding apparatus, easy to usely squeezes into vertebral body.
Present invention also offers described a kind of Bionics Bone girder lumbar fusion cages manufacture method, comprise the following steps:
(1) raw bone girder parameter measurement:
Waist 2 to waist 7 vertebral body is carried out to the CT helical scanning of full vertebral body;
Choose the cross-section and nearly 3mm place of motor end plate, the center of vertebral body and carry out totally three the aspect imagings of 1mm thickness upper, middle and lower;
The process that threshold value is 250HU pixel is carried out to the image obtained, the image pixel lower than 250HU is hidden, produce gray scale figure; Further binary conversion treatment, makes image transform into bianry image;
Establish with the other target measurement district opening graphical analysis, vertebral body center, line length of going forward side by side is calibrated;
Adopt particle quantitative system, the input of image adopts shooting mode;
Grafting Cancellous Bone Bolt girder granule in described image is defined as granule;
By measuring, calculating the bone trabecular average pore size of lumbar vertebra spongy bone and porosity and bone trabecular structure, finally drawing the bone trabecular average pore size of lumbar vertebra and voidage;
(2) object module is set up:
Use Three-dimensional Design Software UG, design the model of the bone trabecula fusion device done of drawing up; After microcomputer modelling, 3D prints, and then on 3D printing device, produces product;
(3) unordered accumulation specific hole cell cube in the bounds of object module; The size of dowel, overall trabecular bone structure precision and outward appearance precision between distance between the size of setting hole cell cube, hole unit, the size of hole cell cube interior tendon, hole cell cube;
Finally delete original object module, retain the trabecular bone structure after filling.
The CT helical scanning condition of described full vertebral body is 120KV, 210mA, 1 cycle per second;
Described establishment opens 10mm so that vertebral body center is other, 400mm altogether2the target measurement district of graphical analysis, and length calibration;
Described employing particle quantitative system, image shows resolution 1024 × 1024 × 8bit, the dynamic static graphics capture card that 1M hardwood is deposited, and the input of image adopts shooting mode, and resolution is 625 lines, 50/second; Adopt full-automatic function.
The index of described graphical analysis comprises: girder amounts of particles in (1) target measurement district; (2) girder particle diameter; (3) girder granule average major axis; (4) girder granule average minor axis; (5) the average flexibility of girder granule.
Need after described formation bone trabecula body to measure micro-pore diameter, overall porosity, if cannot meet the demands, then need to redesign parameter, refill, remeasure after completing;
The original object module of described last deletion, retains the trabecular bone structure after filling, then adds compact texture, be final cartilage pad bone trabecula model.
Described photographic head model is the CCD-MTV-1881CB of Min Tron.
The present invention adopts technique scheme to have following technique effect:
Overcome the effect that traditional intervertebral fusion apparatus can only play physical support in human body, but exist and can not grow into by induced osteogenesis, the technological deficiency improving spinal fusion rate can not be reached.Adopt 3D printing technique, bionical in microstructure, can grow into by induced osteogenesis, reach and improve the effect of spinal fusion rate.
Accompanying drawing explanation
Fig. 1 is hole cell cube figure of the present invention
Fig. 2 is the hole cell cube design sketch after the present invention fills
Fig. 3 is after Fig. 2 shown pores cell parameters of the present invention has set, the trabecular bone structure formed after deleting original filling objective body
The final cartilage pad bone trabecula model of Fig. 4 for being formed after the interpolation of trabecular bone structure shown in Fig. 3 of the present invention compact texture
Wherein, 1-fusion device support column, 2-filling slot, 3-tapered tip portion, 4-manual imitation bone structure, 5-trabecular bone structure, 6-rear connecting portion
Detailed description of the invention
A kind of Bionics Bone girder lumbar fusion cages as shown in Figure 1, Figure 2, Figure 3, Figure 4, comprises the overall trabecular bone structure 5 of fusion device support column 1, filling slot 2, tapered tip portion 3, manual imitation bone structure 4 formation; Described trabecular bone structure 5 is provided with rear connecting portion 6.Described fusion device support column 1 has the effect supporting and fill, and described filling slot 2 is for filling spongy bone and bone; Described tapered tip portion 3 is conducive to squeezing into vertebral body position; Described manual imitation bone structure is the structure after filling; The rear end entity of described rear connecting portion 6, for connecting holding apparatus, easy to usely squeezes into vertebral body.
Described Bionics Bone girder lumbar fusion cages manufacture method, comprises the following steps:
(1) raw bone girder parameter measurement:
Waist 2 to waist 7 vertebral body is carried out to the CT helical scanning of full vertebral body, condition is 120KV, 210mA, 1 cycle per second; Choose the cross-section and nearly 3mm place of motor end plate, the center of vertebral body and carry out totally three the aspect imagings of 1mm thickness upper, middle and lower; The process that threshold value is 250HU is carried out to the image obtained, the image pixel lower than 250HU is hidden, produce gray scale figure, adopt the binary conversion treatment function of this machine further, make image transform into bianry image.
Establish and open 10mm so that vertebral body center is other, 400mm altogether2the target measurement district of graphical analysis, and length calibration.Adopt TJTY-300V1.0 particle quantitative system, image shows resolution 1024 × 1024 × 8bit, the dynamic static graphics capture card that 1M hardwood is deposited, the input of image adopts shooting mode, photographic head model is the CCD-MTV-1881CB of Min Tron, and its resolution is 625 lines, 50/second.Adopt its full-automatic function to reduce the interference of subjective factors.Grafting Cancellous Bone Bolt girder granule in image is defined as granule.The index of graphical analysis comprises: girder amounts of particles (Total Number of Objects, TNO) in (1) target measurement district; (2) girder particle diameter (Mean Diameter, MD); (3) girder granule average major axis (Mean Max-Axis, MMA); (4) girder granule average minor axis (Mean Min-Axis, MNA); (5) the average flexibility of girder granule (Thin-D).
By measuring, calculating the bone trabecular average pore size of lumbar vertebra spongy bone and porosity and bone trabecular structure, finally drawing the bone trabecular average pore size of lumbar vertebra and voidage.Aperture is at 400-600um, and porosity is 70%.
(2) object module is set up
Use Three-dimensional Design Software UG, design the model of the bone trabecula fusion device done of drawing up, as depicted in figs. 1 and 2.
(3) unordered accumulation specific hole cell cube in the bounds of object module, the size of dowel and overall trabecular bone structure precision, outward appearance precision between distance between the size of setting hole cell cube, hole unit, the size of hole cell cube interior tendon, hole cell cube, finally delete original object module, retain the trabecular bone structure after filling.
The performance indications of product of the present invention: (1) porosity is not less than 70%, pore diameter range 400-600 μm: the present invention with human body spongy bone for data model, between each parameter region of Accurate Measurement Grafting Cancellous Bone Bolt girder, by adjustment bone trabecula aperture, porosity, bone trabecula diameter technological parameter, realize control to bone fusion device pore structure, make porosity be not less than 70%, aperture 400-600 μm.
(2) EBM technology shaping strength is not less than 50MPa: by controlling bone trabecula micropore structure, guarantees that the fusion device compressive strength after molding making is not less than 50MPa.This performance overcomes the effect that traditional intervertebral fusion apparatus can only play physical support in human body, but exists and can not grow into by induced osteogenesis, can not reach the technological deficiency improving spinal fusion rate.The present invention is bionical in microstructure, can grow into by induced osteogenesis, reaches and improves the technique effect of spinal fusion rate.
Effect after as shown in Figure 1 and Figure 2 hole cell cube being filled; After parameter setting completes as shown in Figure 3, namely form trabecular bone structure after deleting original filling objective body, need after forming bone trabecula body to measure micro-pore diameter, overall porosity, if cannot meet the demands, then need to redesign parameter, refill, remeasure after completing; Add compact texture shown in Fig. 4, be final cartilage pad bone trabecula model.