技术领域technical field
本发明涉及一种用于单剂的含活性物质的膜或膏药的封装件，该封装件包括上包装材料元件和下包装材料元件，该上、下包装材料元件借助环绕的密封面或密封缝互相连接，从而形成用于容纳膜或膏药的、所有侧都被包围的空腔，其中，上包装材料元件和下包装材料元件在密封面或密封缝的区域中各具有至少一个切口，这些切口是叠合的，并且至少一个切口与折叠线或弯曲线相交。The invention relates to a packaging for a single-dose active substance-containing film or plaster comprising an upper packaging material element and a lower packaging material element, the upper and lower packaging material elements being provided by means of a surrounding sealing surface or sealing seam interconnected so as to form a cavity surrounded on all sides for accommodating the film or plaster, wherein the upper packaging material element and the lower packaging material element each have at least one incision in the region of the sealing surface or sealing seam, these incisions are superposed and at least one cut intersects a fold or bend line.
背景技术Background technique
经皮给药系统(TTS)是用于将活性物质给到皮肤上的类似膏药的药物剂型。在最简单的情况下，TTS包括非常薄的背层、包含活性物质的粘着的聚合物层和可选的可再揭下的保护层，该保护层在使用TTS之前被去除。背层和聚合物层必须非常薄，以便在贴上TTS时不产生异物感。由于该特性，在撕开封装件时，两个层易于受损(下文称为“膏药”)。Transdermal delivery systems (TTS) are plaster-like pharmaceutical dosage forms for delivering active substances to the skin. In the simplest case, a TTS consists of a very thin backing layer, an adhesive polymer layer containing the active substance and an optional re-peelable protective layer which is removed before the TTS is used. The backing layer and polymer layer must be very thin so that the TTS does not create a foreign body sensation when applied. Due to this property, the two layers are susceptible to damage when the package is torn off (hereinafter referred to as "plaster").
这也适于薄膜形的口腔药物剂型，也就是所谓的口腔薄膜(OTF)或晶片，其仅包括聚合物层(下文称为“膜”)。This also applies to oral pharmaceutical dosage forms in the form of films, so-called oral films (OTF) or wafers, which comprise only a polymer layer (hereinafter referred to as "film").
原则上，对于这些类型的药物剂型或者药剂形式，存在对儿童安全的封装件的需求，但是这些封装件必须同时易于被成人打开。In principle, for these types of pharmaceutical dosage forms or medicament forms, there is a need for child-resistant enclosures, but these must at the same time be easily opened by adults.
由DE 10 2004 047 445 A1已知一种用于有害于健康的制品(尤其是制药学制品)的、不可再次封闭的封装件，该封装件包括第一包装材料元件和第二包装材料元件。在此，两个包装材料元件重叠设置并且该封装件具有至少一个第一表面部段，在该表面部段的一个或多个边缘上两个包装材料元件可松开地互相连接，其中，在这两个包装材料元件之间形成有用于容纳封装物品的至少一个所有侧都被包围的空腔。该封装件具有至少一个第二表面部段，该至少一个第二表面部段位于所述第一表面部段之外或者邻接于该至少一个第一表面部段，并且在该至少一个第二表面部段的一个或多个边缘上两个包装材料元件可松开地互相连接，并且其中两个包装材料元件中的至少一个包装材料元件设有至少一种结构，该结构在第二表面部段内部延伸并且该结构允许撕开包装材料元件。DE 10 2004 047 445 A1 discloses a non-reclosable package for health-hazardous products, in particular pharmaceutical products, which comprises a first packaging material element and a second packaging material element. In this case, two packaging material elements are arranged one above the other and the encapsulation has at least one first surface section at one or more edges of which the two packaging material elements are releasably connected to one another, wherein at Formed between the two packaging material elements is at least one cavity surrounded on all sides for receiving the packaged goods. The encapsulation has at least one second surface section located outside or adjacent to the at least one first surface section and on the at least one second surface Two wrapping material elements are releasably connected to each other on one or more edges of the section, and wherein at least one wrapping material element of the two wrapping material elements is provided with at least one structure on the second surface section The interior is extended and the structure allows tearing of the packaging material element.
由DE 10 2006 041 921 A1已知一种用于含活性物质的膜的封装件，该封装件具有载体层和与该载体层可松开地相连的覆盖层。在此，该封装件以成对的布置结构的形式具有两个相对置的、通过隔板互相分开的表面区域，在该表面区域内部覆盖层不与载体层相连，从而形成用于成对地容纳分开的膜的两个互相分开的、所有侧都被包围的腔。在所述隔板内部设有另一个表面区域，在该另一个表面区域中载体层不与覆盖层相连，从而形成在所有侧都被包围的空腔并且在隔板内部有至少一个穿孔线。A packaging for active substance-containing films is known from DE 10 2006 041 921 A1, which has a carrier layer and a cover layer detachably connected to the carrier layer. In this case, the encapsulation, arranged in pairs, has two opposite surface regions separated from one another by a partition, in which surface regions the cover layer is not connected to the carrier layer, so that a pair of grounding elements is formed. Two separate chambers, enclosed on all sides, containing separate membranes. A further surface area is provided within the partition, in which the carrier layer is not connected to the cover layer, so that a hollow space is formed which is surrounded on all sides and at least one perforation line is provided inside the partition.
在这些已知的实施方式中，上包装材料元件和下包装材料元件可松开地(可剥离地)互相连接。In these known embodiments, the upper wrapping material element and the lower wrapping material element are releasably (peelable) connected to each other.
在另一种实施方式中，在单剂封装件中两个包装材料元件不可松开地互相连接。这优选通过热压密封来实现，不过也可以利用各种其它合适的密封方法如冷压密封、超声波压合、激光压合或者类似的对于本领域技术人员已知的箔焊方法来进行，只要得到不可松开的密封缝即可。In a further embodiment, two packaging material elements are non-detachably connected to one another in the unit-dose package. This is preferably accomplished by thermocompression sealing, but various other suitable sealing methods such as cold compression sealing, ultrasonic bonding, laser bonding or similar foil welding methods known to those skilled in the art can also be used, as long as Get a non-releasable sealing seam.
一种这样的封装件例如由德国公开文献DE 10 2009 008 217 A1已知。Such an enclosure is known, for example, from German publication DE 10 2009 008 217 A1.
在封装件的这些已知实施方式中，使用者必须沿着印上的标记线折起封装件的一部分，以便接着在同样作标记的部位上通过沿着削弱线撕开而打开封装件。沿着印上的标记线的折起将两个包装材料元件的密封面或密封缝的区域中的结构或切口的位置变化到该封装件的边缘上，并且因此允许撕开封装件以便能够取出空腔中的内容物。所述结构或切口具有大约3至5mm的长度。印上的标记线优选垂直地或者以所选择的角度与所述结构或切口相交。In these known embodiments of the package, the user has to fold a part of the package along the printed marking line in order to then open the package by tearing along the weakening line at the same marked location. Folding along the printed marking line changes the position of the structures or cuts in the area of the sealing surfaces or sealing seams of the two packaging material elements to the edge of the package and thus allows the package to be torn open for removal contents of the cavity. The structures or incisions have a length of approximately 3 to 5 mm. The printed marking line intersects the structure or incision preferably perpendicularly or at a chosen angle.
已经在DE 10 2009 008 217 A1中指出密封缝和包装材料元件必须考虑封装件的内容物的渗透性能的必要性。在已知的实施方式中关键的是要看到切口的布置结构。It has already been pointed out in DE 10 2009 008 217 A1 that the sealing seam and the packaging material element must take into account the necessity of the permeability of the contents of the package. In the known embodiment it is critical to see the arrangement of the cutouts.
在此，现有技术忽略封装件主要有助于封装的药物剂型的稳定性，因为封装件保护药物剂型免受光、潮湿、氧气和微生物的侵害。所提到的削弱线通过其在密封中造成缝隙而削弱封装件，因为更多湿气和氧气可通过中断的密封而渗透到封装件内部。在此要注意的是，水蒸气和氧气都是非常小的分子并且药剂在使用之前的储藏应该是至少两年、但理想地三年和更久。Here, the prior art ignores that the encapsulation mainly contributes to the stability of the encapsulated pharmaceutical dosage form, since the encapsulation protects the pharmaceutical dosage form from light, moisture, oxygen and microorganisms. The mentioned weakening lines weaken the package by the fact that they create gaps in the seal, since more moisture and oxygen can penetrate into the inside of the package through the interrupted seal. It is to be noted here that both water vapor and oxygen are very small molecules and the storage of the agent before use should be at least two years, but ideally three years and more.
发明内容Contents of the invention
因此，本发明的目的在于，提供一种这种类型的单剂封装件，该单剂封装件改善上述实施方式。尤其应该阻止物质渗透到封装件内部。It is therefore the object of the present invention to provide a single-dose package of this type which improves the above-described embodiments. In particular, penetration of substances into the interior of the enclosure should be prevented.
按照本发明，所述目的通过如下方式实现，即，在上包装材料元件中的切口和在下包装材料元件中的叠合的切口构成为，使得各切口的相应端点相对于空腔具有距离，该距离至少等于密封缝的宽度。According to the invention, this object is achieved in that the cutouts in the upper packaging material element and the overlapping cutouts in the lower packaging material element are formed such that the respective end points of the cutouts have a distance relative to the cavity, which The distance is at least equal to the width of the sealing seam.
此外，有利的是，解决儿童安全的方面，从而本发明满足所要求的DIN EN 14375(用于制药学的产品-要求和测试的、儿童安全的、不可再次封闭的封装件)。Furthermore, it is advantageous to address child safety aspects, so that the invention meets the requirements of DIN EN 14375 (Products for pharmaceutical use—Requirements and tests, child-resistant, non-reclosable enclosures).
因此，本发明涉及一种用于单剂的含活性物质的膜或膏药的封装件，该封装件包括上包装材料元件和下包装材料元件，该上、下包装材料元件借助环绕的密封面或密封缝互相连接，从而形成用于容纳膜或膏药的、所有侧都被包围的空腔，其中，The present invention therefore relates to a package for a single-dose active substance-containing film or plaster comprising an upper packaging material element and a lower packaging material element, the upper and lower packaging material elements being protected by means of a surrounding sealing surface or The sealing seams are interconnected so as to form a cavity surrounded on all sides for accommodating the film or plaster, wherein,
i.)上包装材料元件和下包装材料元件在密封面或密封缝的区域中各具有至少一个切口，这些切口是叠合的，并且i.) the upper packaging material element and the lower packaging material element each have at least one cutout in the region of the sealing surface or sealing seam, these cutouts are congruent, and
ii.)在i.)中的至少一个切口与折叠线或弯曲线相交，并且ii.) at least one of the cuts in i.) intersects a fold or bend line, and
iii.)在i.)中的、在上包装材料元件中的切口和在下包装材料元件中的叠合的切口构成为，使得i.)中的切口的相应端点相对于空腔或者空腔边缘具有距离(M1)，该距离至少等于密封缝的宽度(M2)。iii.) In i.), the cutout in the upper packaging material element and the overlapping cutout in the lower packaging material element are formed such that the respective end points of the cutout in i.) are relative to the cavity or cavity edge There is a distance (M1) which is at least equal to the width (M2) of the sealing seam.
在本发明的另一种优选的实施方式中，密封缝(M2)的宽度是1至25mm、优选2至10mm、尤其优选4至8mm。相应地，在iii.)中的按照本发明的距离M1至少是M2的长度或者更长，然而优选的是，M1不是等于而是长于M2、尤其具有比M2多20％至30％的量。在图1中示出一个开放的实例。此外优选的是，密封缝构成为相同形状的。如果例如密封缝的宽度(M2)选为5mm，那么M1可以是5mm和更长、优选6至10mm。In another preferred embodiment of the invention, the sealing seam ( M2 ) has a width of 1 to 25 mm, preferably 2 to 10 mm, particularly preferably 4 to 8 mm. Correspondingly, the distance M1 according to the invention in iii.) is at least the length of M2 or longer, but preferably M1 is not equal to but longer than M2, in particular by an amount of 20% to 30% greater than M2. An example of an opening is shown in FIG. 1 . Furthermore, it is preferred that the sealing seams are formed with the same shape. If, for example, the width (M2) of the sealing seam is chosen to be 5 mm, then M1 can be 5 mm and longer, preferably 6 to 10 mm.
因此，本发明规定，切口的端点与空腔的距离至少与其余密封缝的最大宽度一样大。每个封装件至少在三侧上具有密封缝，这些密封缝的宽度考虑用于避免或者阻止在最大保存限期的时间段内的渗透。Therefore, the invention provides that the distance of the end point of the cutout from the cavity is at least as great as the maximum width of the remaining sealing seam. Each enclosure has sealing seams on at least three sides, the width of which is taken into account to avoid or prevent penetration during the period of the maximum shelf life.
靠外的层优选是可印刷的，从而例如可以安装产品标志和撕开辅助装置。The outer layer is preferably printable so that, for example, product logos and tear-off aids can be fitted.
第二层或者在三层构造中的中间层由9至25微米厚度的金属箔、优选铝制成。该金属层确保实现封装件相对于湿气和空气的密封性。The second layer or the middle layer in a three-layer construction is made of a metal foil, preferably aluminum, with a thickness of 9 to 25 micrometers. This metal layer ensures that the sealing of the package with respect to moisture and air is achieved.
靠内的层是有密封能力的塑料层，其中，由该层产生的密封缝不可再次打开。The inner layer is a sealing plastic layer, wherein the sealing seam produced by this layer cannot be opened again.
在一种优选的实施方式中，上包装材料元件和下包装材料元件具有相同构造。这具有如下优点，即，仅使用一种包装材料并且以此防止混淆。In a preferred embodiment, the upper packaging material element and the lower packaging material element have the same configuration. This has the advantage that only one packaging material is used and thus prevents confusion.
一种符合目的的扩展方案规定，在上料封装元件的切口和在下包装材料元件的切口这样安装在密封缝中，使得切口相对于最近的空腔外边缘垂直定向。以此确保切口正好在唯一一个点上与环绕的密封面或密封缝接触，而在已知的实施方式中在较长的长度上进行接触。An expedient refinement provides that the cutouts of the upper packaging element and the cutouts of the lower packaging material element are arranged in the sealing seam in such a way that the cutouts are oriented vertically relative to the nearest outer edge of the cavity. This ensures that the notch comes into contact with the surrounding sealing surface or sealing seam at exactly one point, whereas in the known embodiment the contact occurs over a longer length.
此外优选的是，上述的切口沿着切口线相对于所引入的膜或膏药具有足够的距离，从而在撕开时不出现损坏。在图1中示例性地看出合适的距离M3。Furthermore, it is preferred that the aforementioned incisions have a sufficient distance along the incision line relative to the introduced film or plaster, so that no damage occurs during tearing. A suitable distance M3 is shown by way of example in FIG. 1 .
在一种特别的实施方式中，上包装材料元件和下包装材料元件构成为一件式的并且在此围绕折边折叠。In a particular embodiment, the upper packaging material element and the lower packaging material element are formed in one piece and are folded around the fold here.
在两个包装材料元件之间的连接优选通过密封或者焊接来产生。用于产生密封面或密封缝的合适的工具和方法对本领域技术人员是已知的。密封用作渗透屏障和扩散屏障并且一般不允许活性物质和空气湿气通过。可考虑热压密封法和冷压密封法。例如可以使用热熔胶、封蜡、密封分散剂或者粘合剂作为密封层的材料。The connection between two packaging material elements is preferably produced by sealing or welding. Suitable tools and methods for producing sealing surfaces or sealing seams are known to those skilled in the art. The seal acts as a permeation and diffusion barrier and generally does not allow the passage of active substances and air moisture. Heat-press sealing method and cold-press sealing method can be considered. For example, hot melt adhesives, sealing waxes, sealing dispersions or adhesives can be used as material for the sealing layer.
此外，本发明涉及一种用于制造用于单剂的含活性物质的膜或膏药的封装件的方法，该方法包括如下步骤：Furthermore, the invention relates to a method for the manufacture of a capsule for a single-dose active substance-containing film or plaster, the method comprising the steps of:
i.)提供上包装材料元件和下包装材料元件，该上、下包装材料元件借助环绕的密封面或密封缝互相连接，从而形成用于容纳膜或膏药的、所有侧都被包围的空腔，其中，i.) Provide an upper packaging material element and a lower packaging material element, the upper and lower packaging material elements are connected to each other by means of a surrounding sealing surface or sealing seam, so as to form a cavity surrounded on all sides for accommodating the film or plaster ,in,
ii.)将上包装材料元件和下包装材料元件在密封面或密封缝的区域中各添加至少一个切口，这些切口是叠合的，并且ii.) adding at least one incision each to the upper and lower packaging material elements in the region of the sealing surface or sealing seam, these incisions being congruent, and
iii.)安装折叠线或弯曲线，该折叠线或弯曲线与ii.)中的至少一个所述切口相交，iii.) installing a fold or bend line which intersects at least one of said cuts in ii.),
其中，将在ii.)中的、上包装材料元件中的切口和在下包装材料元件中的叠合的切口构成为，使得这些切口的相应端点相对于上述的空腔具有距离(M1)，该距离至少等于i.)中的密封缝的宽度(M2)。In ii.), the cutouts in the upper packaging material element and the overlapping cutouts in the lower packaging material element are formed in such a way that the respective end points of these cutouts have a distance (M1) relative to the above-mentioned cavity, which The distance is at least equal to the width (M2) of the sealing seam in i.).
按照本发明的方法也可以按照上述的和下述的特征进一步设计。尤其是，ii.)中的至少一个切口可以相对于i.)中的最近的空腔外边缘垂直定向。The method according to the invention can also be further developed according to the features mentioned above and below. In particular, at least one cutout in ii.) may be oriented vertically with respect to the nearest cavity outer edge in i.).
此外，本发明涉及一种上述封装件的用途，所述封装件用于容纳单剂，如含活性物质的膜、晶片或者膏药，所述膏药尤其是TTS膏药。Furthermore, the invention relates to the use of a package as described above for containing individual doses, such as active substance-containing films, wafers or plasters, especially TTS plasters.
附图说明Description of drawings
本发明的其它特征和细节由接下来对本发明的以示意性附图示出的实施例的描述得出。其中：Further features and details of the invention emerge from the following description of an exemplary embodiment of the invention shown in the schematic drawings. in:
图1以俯视图示出一种用于含活性物质的膜的封装件；和Figure 1 shows a package for an active substance-containing film in top view; and
图2以剖视的侧视图示出图1中的封装件；Figure 2 shows the package in Figure 1 in a cutaway side view;
具体实施方式detailed description
在图1中以俯视图示出一种按照本发明的封装件1。封装件1是包括上包装材料元件3和下包装材料元件4的边缘密封袋。在上包装材料元件3和下包装材料元件4之间，含活性物质的膜2设置在所有侧都被包围的空腔6中。空腔6通过环绕的密封面或密封缝5产生，该密封面或密封缝将两个包装材料元件3、4不可松开地连接。空腔6和密封面或密封缝5具有一个共同的外边缘6a。在密封面或密封缝5中，一个切口7位于上包装材料元件3中并且一个切口8位于下包装材料元件4中。两个切口7和8是叠合的。切口7与折叠线或弯曲线10相交。FIG. 1 shows a package 1 according to the invention in plan view. The package 1 is an edge-sealed bag comprising an upper wrapping material element 3 and a lower wrapping material element 4 . Between the upper packaging material element 3 and the lower packaging material element 4 , the active substance-containing film 2 is arranged in a cavity 6 which is surrounded on all sides. The cavity 6 is produced by a circumferential sealing surface or sealing seam 5 which connects the two packaging material elements 3 , 4 in a non-detachable manner. The cavity 6 and the sealing surface or sealing seam 5 have a common outer edge 6a. In the sealing surface or sealing seam 5 , a cutout 7 is located in the upper packaging material element 3 and a cutout 8 is located in the lower packaging material element 4 . The two cutouts 7 and 8 are congruent. The cut 7 intersects a fold or bend line 10 .
切口7和8的与撕开边缘相同的假想延长部距最近的、含活性物质的膜2的边缘具有距离M3。在一种优选的实施方式中距离M3是4至5mm。The same imaginary extensions of the cutouts 7 and 8 as the tear-off edges are at a distance M3 from the edge of the nearest active substance-containing film 2 . In a preferred embodiment the distance M3 is 4 to 5 mm.
在另一种实施方式中，上包装材料元件3和下包装材料元件4构成为一件式的并且围绕折边17折叠。在此，在该区域中没有密封缝5。In a further embodiment, the upper packaging material element 3 and the lower packaging material element 4 are formed in one piece and folded around the fold 17 . Here, there is no sealing seam 5 in this region.
在图2中以沿着在图1中的线A–A的剖视图示出封装件的构造。各个部件被很大程度地放大并且分开示出，以便详细示出该构造。上包装材料元件3至少包括一个靠外的上层11和一个接着的上金属层13。The configuration of the package is shown in FIG. 2 in a sectional view along the line A—A in FIG. 1 . Various components are greatly enlarged and shown separately in order to illustrate the construction in detail. The upper packaging material element 3 comprises at least one outer upper layer 11 and a subsequent upper metal layer 13 .
下包装材料层4同样包括一个靠外的下层12和一个接着的下金属层14。The lower packaging material layer 4 likewise comprises an outer lower layer 12 and a subsequent lower metal layer 14 .
金属层13、14优选由厚度为9至25微米的铝箔制成。该箔确保装入的产品不与空气接触并且不遭受湿气。The metal layers 13, 14 are preferably made of aluminum foil with a thickness of 9 to 25 micrometers. This foil ensures that the enclosed product does not come into contact with the air and is not subjected to moisture.
至少在密封面或密封缝5的区域中，上包装材料元件3或下包装材料元件4具有一个有密封能力的层或密封层9。但是，密封层9也可以安装在两个(即上、下)包装材料元件3、4上。通过该层9产生的密封面或密封缝5不可再次分开。At least in the region of the sealing surface or sealing seam 5 , the upper packaging material element 3 or the lower packaging material element 4 has a sealing layer or sealing layer 9 . However, the sealing layer 9 can also be applied to both (ie upper and lower) packaging material elements 3 , 4 . The sealing surface or sealing seam 5 produced by this layer 9 cannot be separated again.
附图标记列表：List of reference signs:
1 封装件1 package
2 含活性物质的膜2 Membranes with active substances
3 上包装材料元件3 Upper packing material element
4 下包装材料元件4 Lower packing material elements
5 密封面或密封缝5 sealing surface or sealing seam
6 空腔6 cavities
6a 空腔6的外边缘6a Outer edge of cavity 6
7 切口7 cuts
8 切口8 cuts
9 密封层9 sealing layer
10 折叠线或弯曲线10 Fold or bend lines
11 靠外的上层11 outer upper level
12 靠外的下层12 outer lower level
13 上金属层13 upper metal layer
14 下金属层14 lower metal layer
15 切口7的端点15 End point of cutout 7
16 切口8的端点16 End point of cutout 8
17 折边17 hem
M1 距离1M1 distance 1
M2 距离2M2 distance 2
M3 距离3M3 distance 3
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12005237.8 | 2012-07-17 | ||
| EP20120005237EP2687458A1 (en) | 2012-07-17 | 2012-07-17 | Package for films with a unitary dosage of an active substance |
| PCT/EP2013/063922WO2014012787A1 (en) | 2012-07-17 | 2013-07-02 | Pack for individual active‑substance‑containing films, and method for producing said pack |
| Publication Number | Publication Date |
|---|---|
| CN104640781A CN104640781A (en) | 2015-05-20 |
| CN104640781Btrue CN104640781B (en) | 2016-11-09 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380044805.XAActiveCN104640781B (en) | 2012-07-17 | 2013-07-02 | Encapsulation for single-dose active substance-containing film and method for producing the same |
| Country | Link |
|---|---|
| EP (2) | EP2687458A1 (en) |
| JP (1) | JP6422436B2 (en) |
| KR (1) | KR20150032702A (en) |
| CN (1) | CN104640781B (en) |
| AU (1) | AU2013292245B2 (en) |
| BR (1) | BR112015000813B1 (en) |
| CA (1) | CA2878330C (en) |
| ES (1) | ES2605432T3 (en) |
| MX (1) | MX351124B (en) |
| PL (1) | PL2874908T3 (en) |
| RU (1) | RU2633954C2 (en) |
| WO (1) | WO2014012787A1 (en) |
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| JP2015217970A (en)* | 2014-05-19 | 2015-12-07 | 大日本印刷株式会社 | Package |
| DE102021100782B3 (en)* | 2021-01-15 | 2022-07-14 | Lts Lohmann Therapie-Systeme Ag. | OTF CONNECTION BY SEWING |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3809220A (en)* | 1972-07-24 | 1974-05-07 | Becton Dickinson Co | Child safety package |
| US5511665A (en)* | 1994-10-31 | 1996-04-30 | G. D. Searle & Co. | Child-resistant package |
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| DE102004062864A1 (en)* | 2004-12-21 | 2006-06-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | foil container |
| US20060283747A1 (en)* | 2005-06-07 | 2006-12-21 | Gloria Lam Family Partnership, Llc | Condiment package with advertising for others |
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| DE102009008217A1 (en)* | 2009-02-10 | 2010-08-19 | Lts Lohmann Therapie-Systeme Ag | Child-proof, highly inert single-pack |
| WO2012084216A1 (en)* | 2010-12-23 | 2012-06-28 | Lts Lohmann Therapie-Systeme Ag | Tightly sealing single dose packaging |
| Publication number | Publication date |
|---|---|
| CA2878330A1 (en) | 2014-01-23 |
| JP2015524290A (en) | 2015-08-24 |
| AU2013292245B2 (en) | 2016-08-18 |
| BR112015000813B1 (en) | 2021-01-26 |
| EP2687458A1 (en) | 2014-01-22 |
| PL2874908T3 (en) | 2017-05-31 |
| ES2605432T3 (en) | 2017-03-14 |
| HK1209713A1 (en) | 2016-04-08 |
| MX2015000790A (en) | 2015-05-07 |
| EP2874908A1 (en) | 2015-05-27 |
| CN104640781A (en) | 2015-05-20 |
| RU2015105053A (en) | 2016-09-10 |
| KR20150032702A (en) | 2015-03-27 |
| BR112015000813A2 (en) | 2017-06-27 |
| EP2874908B1 (en) | 2016-09-07 |
| RU2633954C2 (en) | 2017-10-19 |
| MX351124B (en) | 2017-10-02 |
| AU2013292245A1 (en) | 2015-02-05 |
| CA2878330C (en) | 2020-04-14 |
| WO2014012787A1 (en) | 2014-01-23 |
| JP6422436B2 (en) | 2018-11-14 |
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| ES2364510T3 (en) | PACKAGE FOR FILMS CONTAINING ACTIVE SUBSTANCE AND PROCEDURES FOR MANUFACTURING. | |
| KR101899616B1 (en) | Tightly sealing single dose packaging | |
| CN105026283A (en) | Tear-open pouch for fragile thin materials | |
| CA2592057C (en) | Film container | |
| JP2008514517A (en) | Non-resealable packaging for products harmful to health and method for producing the same | |
| CN104640781B (en) | Encapsulation for single-dose active substance-containing film and method for producing the same | |
| CN104159729B (en) | Packaging material, the packaging produced by it, and the method for structure packaging | |
| HK1209713B (en) | Pack for individual active-substance-containing films, and method for producing said pack | |
| US9004280B2 (en) | Single-dose package for transdermal therapeutic system or sheet-like administration forms | |
| HK1182068A (en) | Wafer pocket with tear-open wafer accommodating compartment | |
| HK1110566A (en) | Film container |
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