Embodiment
The present invention relates to a kind of system of one or more implanted devices and exciting bank, a kind of implanted device, Yi JiyiPlant using the system and for the method for the one or more devices for treating artery and venous structures.The invention further relates to be implanted intoDevice, the system of implanted device and external drive part and for by one or more implanted devices positioning in the blood vessel, withAfter heat these implanted devices, preferably while heating these implanted devices, heat thus being delivered into blood from implanted deviceThe method of inside pipe wall.
Unless otherwise defined, all terms used in present invention disclosed, comprising technology and scientific terminology, it containsJustice is commonly one skilled in the art of the present invention and understood.By further guidance, term is defined by comprising with more preferableGround recognizes the teachings of the present invention.
As used in this article, following term has following meanings：
Indefinite article and definite article as used in this article refer to both odd number and plural reference, unless context is in additionClear stipulaties.For example, " compartment " refers to one or more than one compartment.
As used in this article " about ", measurable magnitude parameter, amount, time limit etc. are referred to, it is intended that cover specified+/- 20% or less of value changes, it is preferable to +/- 10% or less, and more preferably +/- 5% or less, even more can be excellentSelection of land +/- 1% or less, will also more preferably +/- 0.1% or less, up to the present, suitable perform of such change existsIn present invention disclosed.However, it should be understood that the signified value of modifier " about " is also specifically disclosed in itself.
" comprising " as used in this article and its modification are synonymous with "comprising" and its modification or " containing " and its modification, andIt is to specify the presence of such as device therewith and do not repel or exclude known in the art or disclosed herein do not quote from device in additionPart, feature, element, component, the pardon of the presence of step or open term.
Number range is stated by end points and includes all integers and the fraction that are included into the range of this, and the end points being expressed.
" weightening ... % " (percentage by weight), in this and entire disclosure unless otherwise defined, refers to base for statementIn the relative weight of the respective device of formation overall weight.
Statement " implant " and " implanted device " is used interchangeably in this application.The implanted device used such as this contextRefer to artificial tubes or tubing device, i.e., the device being at least partially opened with circumferential wall and in top and bottom, wherein instituteOpening or hole can be had or can not have by stating circumferential wall, and pipe or the tubing device is intended to be placed on patient body such as veinInternal blood vessel, or it is placed on the internal blood vessel of human or animal's corpse or human body or animal model.In the present context, term" implant " and " implanted device " will be placed in the blood vessels to keep the blood vessel to open fluid not necessarily referring to device, stillThis can be one of effect of device.However, implanted device mean to be placed in in the relative fixed position of blood vessel, andAnd because the fluid stream by blood vessel is without movement.When " being implanted " device using term, it means implanted plantEnter thing or implanted device.In one embodiment, implanted device is holder device, it is intended that the Expected Results of described device is to plantFashionable holding blood vessel is opened to fluid.
Term " conduit " and " sheath " are used interchangeably in this application.
Term " lead " is used for the device that can be controllably guided when in insertion body in this application.It is being preferable to carry outIn mode, it is conduit, i.e. guiding catheter.In another embodiment, it is solid and without tube chamber.
Term " Curie temperature " and " Ne＆1＆el temperature " refer to that exceeding the ferromagnetic temperature, anti-ferromagnetically and ferrimagnetic material becomesParamagnetism or diamagnetism, and be hereinafter used interchangeably.
It is synonym that " resistance heating " and " Joule heating ", which is used, in this and whole text, and refers to that electric current passes throughConductor discharges the process of heat.
It is synonym that " thermal switch " and " temp control switch ", which is used, in this and whole text, and refers to depending onTemperature value can close or open the switch of one or more circuits.The temperature can be the temperature of the position of the switch, or can be withIt is the temperature obtained in diverse location.The embodiment of thermal switch is further presented in the body of the email.
In a first aspect, be used for the system from internal ablation at least a portion vascular wall the invention provides a kind of, including：
- self-expanding implanted device, is suitable for implantation into and is deployed in and be described intravascular；Wherein described implant is included along at leastThe ablation areas of its a part of length, the ablation areas is suitable to contact with the blood vessel surface, and the ablation areas is extremelyIt is few effectively to melt the blood vessel when applying energy to implant to and with complete perimeter band or hurricane band substantiallyInterior signal jam path；
- external energy provides part, is spatially separating with implanted device and can supply energy to implanted device, to improveThe temperature of the ablation areas of implanted device is until ablation temperature.
Implanted device is self-expanding, for example, being formed by marmem, and is configured to rest upon such as arteria renalisInwall on.Implant is formed as ring, spiral, the spiral progressively wound or other suitable shapes.It can have anchor partSuch as hook or barb, near end.Implanted device may include ablation areas, and it is contacted with the ablation areas of vascular wall.CanPreferably, ablation areas includes basic complete perimeter band or the hurricane band being located at around vascular wall, or positioned at vascular wall weekThe perimeter band or hurricane band of point-like, dotted line or the interruption enclosed.Ablation areas may include the complete week being located at around blood vesselTo band or hurricane band, or ablation areas may include be located at vascular wall around complete perimeter band or hurricane band and this be directed toBe wall full-thickness." basic " means ablation areas so that all electric signals from ablation areas side are not up toOpposite side, i.e. signal jam path is ablated to.By electromagnetic radiation by external component, by the delayed heating through time-varying magnetic field,By directly or indirectly sense and by Joule heating, by sound, mechanical oscillation and chemical energy means, by heat/chemistry orMechanical/chemical discharges system, and energy can be supplied to implanted device.
The present invention is that one or more implanted devices can be heated simultaneously, can better than an advantage of prior artThe same time that is transmitted in for measuring implant occurs, and need not be sequentially completed.Which save the time and add patient relaxAppropriateness.By the built-in control to temperature, such as by using the magnetic material with specified Curie temperature or by plantingEnter and appropriate heat-barrier material is used in thing, energy transmission in addition will not be in further increase temperature accumulation in implant.
Part is provided by " outside " energy and means that these parts are spatially separating with implanted device, i.e., provide part in energyThere is no physical connection between implanted device, or, more specifically, energy provides part completely in exterior, andThe skin of patient can be remained intact while energy is provided.
The temperature of ablation areas is specified according to the need for treatment.Depending on required ablation temperature, implanted device canTo be designed to by using the magnetic for the material for being constituted implanted device and hot attribute in certain area warmer than other regionsIt is warm.In one embodiment, the portion that each several part of implanted device can be with the other parts of implanted device or with body or body fluidDivide and be thermally isolated.
In a preferred embodiment, the system include more than one implanted device, each implanted device be suitable for implantation into andIt is deployed in one or more intravascular.These implanted devices each may be adapted to be implanted into and be deployed in one or more arteria renalisIt is interior.
In particularly preferred embodiments, one or more implanted devices of the system are included with the first diameterProximal portion and the distal portion with Second bobbin diameter, Second bobbin diameter are less than the first diameter and the implant is placed in one enoughIt is individual or multiple intravascular.
In particularly preferred embodiments, one or more implanted devices of the system are included with the first diameterProximal portion and the distal portion with Second bobbin diameter, Second bobbin diameter are more than or equal to the first diameter and enough pacify the implantPut one or more intravascular.
It should be clear that the shape of implanted device may be adapted to be installed in specific blood vessel.
In order to make the shape and size of implant, change may be collected by scanning technique such as CT scan or MRIThe data of the blood vessel of diameter.According to these data, such as, for all two arteria renalis patients, people can derive implantNecessary shape and size.This measurement can be completed again in the case of no surgical operation, thus increase the comfortable of patientDegree and health and reduce medical-risk.After this measurement, implant can coordinate one or more blood of patient with customizedPipe.
In a preferred embodiment, at least a portion of one or more implanted devices of the system is by display magnetic hysteresisAt least one material is made, such as ferromagnetic, Ferrimagnetic or anti-ferromagnetically material.In addition, external energy provide part can at one orTime-varying magnetic field is formed at the position of multiple implanted devices.In preferred embodiment, the time-varying magnetic field is formed by electric coil,Changing currents with time, which is sent, passes through electric coil.
Magnetic hysteresis is derived from the excessive of material.Most well-known and most-often used is ferromagnetic, anti-ferromagnetically and ferrimagnetic material.TheseMagnetic properties with nonlinearity, i.e. induced magnetic fields not directly to material internal to be applied in magnetic field proportional.However, superCertain temperature, referred to as Curie or Ne＆1＆el temperature are crossed, all these materials lose its specific magnetic properties.The temperature is for tool(material-specific) of body material.More than the temperature, ferromagnetic, anti-ferromagnetically and ferrimagnetic material become paramagnetism or anti-Magnetic, and thus lose its nonlinear magnetic properties.The nonlinear magnetic properties of ferromagnetic, anti-ferromagnetically and ferrimagnetic materialCan by application time-varying magnetic field when observe delayed be inferred to.
Observe the magnetic hysteresis of magnetic material, such as ferromagnet.It is ferromagnetic to be mainly characterized by the presence of spontaneous manetization.Ferromagnet is normalOften it is not uniform magnetization, and is divided into farmland (domains) -- the region of uniform spontaneous manetization, its magnetization degree (per unit volumeMagnetic moment) be consistent, but direction is different.In the case where damaging other farmlands, under the influence of external magnetic field, along field magneticQuantity and the size increase on the farmland of change.Moreover, the magnetic moment on certain farmland can side on the scene rotate up.As a result, the magnetic moment of sampleIncrease.
The magnetic moment M of ferromagnetic sample to the intensity H of external magnetic field correlation (magnetization curve) figure 16 illustrates.EnoughIn strong magnetic field, sample be magnetized to saturation (therewith, field further increases, M values keep it is almost unchanged -- point A).Here, sampleIt is made up of a farmland, saturation Ms magnetic moment is orientated along field.Reduced with the intensity H of external magnetic field, the magnetic moment M of sample will be alongCurve I declines, and is fundamentally outward appearance and growth because farmland, and its magnetic moment is orientated against field.Domain growth is due to the fortune of domain wallIt is dynamic.The motion is hindered because of the presence of various defects (such as impurity or inhomogeneities) sample, this enhances farmland at some pointsWall；Very strong magnetic field needs to shift them.Therefore, as field H drops to zero, so-called remaining magnetic moment Mr (point B) is protectedStay.Sample can be in sufficiently strong field only in the opposite direction by complete demagnetization, and this is referred to as coercive field (coercivity) Hc (pointsC).Further increase with the magnetic field of opposed orientation, sample is magnetized to saturation (point D) along field again.Magnetic is reversed (from point DTo point A) occur along curve II.Therefore, as field undergoes periodically-varied, the curve for characterizing the change of sample magnetic moment forms magneticHysteresis curves.If field H periodic variations, so limitation makes magnetization not up to saturation, then non-limiting hysteresis curve is able toProduce (curve III).By reducing field H to zero change degree, sample can demagnetization (can reach point O) completely.Sample fromPoint O magnetization is advanced along curve IV.
Under magnetic hysteresis, magnetic moment M different value corresponds to external magnetic field strength H identical value.The nonuniqueness is due to elder generationIn the influence of the sample state (that is, the magnetic foregoing history of sample) of given state.
The shapes and sizes and amount Hc of hysteresis curve can be in the range of various ferromagnetic extensive limitations.For example,In pure iron, Hc=1 oersteds, and in magnico alloys, Hc=580 oersteds.Hysteresis curve is subject to processing the strong shadow of materialRing, during material is handled, the quantity of defect changes.The area of hysteresis curve is equal to sample in a cycle of change on the sceneThe energy of this loss.Cumulative volume of the energy also to ferromagnetic material in sample is proportional.The energy is eventually for heating sample.ThisThe energy loss of sample is referred to as hysteresis loss.(for example, in semiconductor substrate and motor in the case of hysteresis loss is inadvisableStator and rotor in), use the soft magnetic materials with low Hc and minor loop area.On the other hand it is necessary to have high HcHard magnetic material manufacture permanent magnet.
With frequency (quantity of the time per unit magnetic turn-around period) increase of alternating magnetic field, led by vortex and magnetic viscosityThe other losses caused are added into hysteresis loss.At high frequencies, the area of hysteresis curve accordingly increases.Returned with above-mentioned static stateLine is contrasted, and such loop line is sometimes referred to as dynamic loop line.
Ferromagnetic many attributes, such as resistance and mechanically deform, depending on magnetic moment.Magnetic moment, which changes, also brings these attributesChange -- for example, respectively observe electrical effect and magnetostriction it is delayed.
Hysteresis curve depends on temperature.The magnetic material that Figure 17 shows typical temperature and Curie or Ne＆1＆el temperature is 140 DEG CThe correlation of the hysteresis curve of material.It is noted that the temperature dependency of shape is only characterization, list is not provided on axisPosition, this figure means illustrative purposes.It was observed that, hysteresis curve changes with temperature, becomes more acute thinner, finally disappear to Curie orNe＆1＆el temperature.Since the temperature, material becomes paramagnetism or diamagnetism, and due to delayed without observing that heating is damagedLose.This means material is no longer heat up, hysteresis effect is at least not due to, and be maintained at Curie or Ne＆1＆el temperature.(underText, two terms " Curie " and " Nai Er " temperature can be with used interchangeablies.) it is noted that due to it is other influence such as directly orThe heating for connecing sensing is still possible, but these influences are ignored in the present case, especially when being brought with hysteresis effectHuge heating efficiency is such when comparing.
Now to those skilled in the art it should be clear that when the ablation areas of implanted device includes Curie temperature exampleWhen being such as 40 DEG C of material, for example, part is provided by the external energy of present system, implant will be heated until the temperatureDegree, and it is not more than when being subjected to time-varying magnetic field the temperature.If ablation temperature needs to be 42 DEG C or 45 DEG C, make in implantMagnetic material is variable more to make the temperature be Curie temperature.This can constitute for example, by changing the alloy of magnetic materialComplete.The Curie temperature of magnetic material can be designed highly precisely.
In a preferred embodiment, the magnetic material used in implanted device is combination or the alloy of following material：ArsenicManganese, gadolinium, the gadolinium with thin iron coating, from the nickel-ferro alloy with about 29.5% nickel of 1000 DEG C of Slow coolings, with 30%Ni-Fe, chromium, cobalt oxide, the zinc ferrite of nickel are Curie or Ne＆1＆el temperature more than 10,20,25,30,35,40 DEG C and/or be less than75th, 70,65,60,55,50,45,40 DEG C of any magnetic material.
The Curie or Ne＆1＆el temperature of alloy or composite can depend highly on the technological procedure for manufacturing these materials.EspeciallyIt, annealing process is important.Further, it is possible to use the other manner of change Curie temperature, such as ionizing radiation, to provide the phaseThe material of prestige.People can use any magnetic material, alloy, bianry alloy, ternary alloy three-partalloy or quaternary alloy, desired CurieOr Ne＆1＆el temperature such as standard reference works are such asSpecified in database.
In another embodiment, the system also includes：
- sheath, is adapted to one or more implanted devices be transported and are sent to the expectation in one or more blood vesselsPosition or near；
- lead, is adapted to the sheath with one or more implants being directed to successively in one or more blood vesselsDesired locations.
Sheath in the embodiment includes implantation substance delivery system, can transmit one or more plants as described in textEnter device.The embodiment of such sheath with conveyer and lead figure 12 illustrates.
It yet still another aspect, endovascular self-expanding implanted device is suitable for implantation into and is deployed in the invention provides one kind；InstituteStating implant includes the ablation areas along its length of at least a portion, and ablation areas is suitable to contact with blood vessel surface, and disappearsAt least effectively melted when applying energy to implant to and with complete perimeter band or hurricane band substantially in tabetisol domainEndovascular signal jam path；Wherein described ablation areas includes at least one material of display magnetic hysteresis, such as ferromagnetic, ferrous ironMagnetic or anti-ferromagnetically material.
It may be preferred that the material includes iron content fluid, that is, the ferromagnetic, Ferrimagnetic that is suspended in heat-transfer fluid and/orAnti-ferromagnetically particle, wherein the material is preferably contained in the implanted device.It is described to plant in preferred embodimentEntering device includes one or more fluid tight chamber, and the fluid tight chamber includes the iron in the heat-transfer fluidMagnetic, Ferrimagnetic and/or anti-ferromagnetically particle.In even more preferably embodiment, the particle includes any or any combinationsFollowing material：SrFe12O19、Mea-2W、Mea- 2Y and Mea- 2Z, wherein 2W are BaO:2MeaO:8Fe2O3, 2Y is 2 (BaO:MeaO:3Fe2O3), and 2Z is 3BaO:2MeaO:12Fe2O3, and wherein MeaIt is bivalent cation, wherein bivalent cation canIt is preferably chosen from magnesium, cobalt, manganese and zinc, and/or 1MebO:1Fe2O3, wherein MebO is the transition metal selected from nickel, cobalt, manganese and zincOxide, and/or metal alloy such as La0.8Sr0.2MnO3、Y3Fe5-xMxO12, wherein M is aluminium or gadolinium and 0<x<2, and/orPalladium, cobalt, nickel, iron, copper, any combination of metal alloy of aluminium and silicon, and/or gadolinium, thorium, dysprosium, holmium, any combinations of erbium and thulium withAny combination of metal alloy of nickel, cobalt and iron, and/or metal alloy RMn2X, wherein R are rare earth such as lanthanum, cerium, praseodymium or niobiums,And X is that germanium or silicon are any.Any combinations of particularly preferably any following alloy or following alloy：With 28% or 29.6%NiCu, NiPd, the PdCo with 6.15% palladium, the NiSi with 4% nickel, (Ni, ZnO) Fe of nickel2O3、La0.8Sr0.2MnOx、Y3Fe5-xAlxO12, wherein 1.0≤x≤1.7.Particle can have any size, and longest dimension is preferably longer than 10 nanometers,More preferably it is longer than 20 nanometers, and longest dimension is less than 500 microns, it is preferable to less than 100 microns.In some embodiment partyIn formula, the longest dimension of the particle is less than 1 micron, it is preferable to less than 200 nanometers.In other embodiments, describedThe longest dimension of grain is longer than 1 micron, it is preferable to be longer than 20 microns.It may be preferred that the fluid that the particle suspends includesOptimal heat conductivity properties.In a preferred embodiment, the fluid includes big thermal capacity.In another preferred embodiment,The fluid includes low thermal capacity.Magnetic material for particle is used and exact nature, amount and group used in fluidClose and depend on preferred temperature and heat, the complete helix for for example inducing arteria renalis inwall melts.In a preferred embodiment,The magnetic material include Curie or Ne＆1＆el temperature be 37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52nd, 53,54,55 DEG C or between any value or its any combinations, it is preferable to the Curie or Ne＆1＆el temperature are less than 75 DEG C, morePreferably it is less than 70 DEG C, is even more preferably less than 65 DEG C, it is also more preferably small still more preferably less than 62 DEG CIn 59 DEG C, 57 DEG C are even more preferably less than increasingly, to be also even more preferably less than 55 DEG C.
In a preferred embodiment, implanted device is suitable for implantation into and is deployed in the arteria renalis.
In particularly preferred embodiments, each several part of implanted device is by display magnetic hysteresis and with different Curie or Nai ErThe more than one material of temperature is made.
Different temperatures causes different lesions in diverse location, and which kind of includes depending on which ablation areas of implanted deviceMaterial.By the way that each several part for the implanted device being made up of the material with different Curie temperature is thermally isolated, temperature is melted along plantThe gradual change for entering device is possible.In addition, the part including the material with more high heat capacity will be more slowly heated, but will be at itAfter keep hot more long, etc..The design of Ablation characteristic can utilize the material used in implant by designing implantMagnetic and hot attribute complete.
In preferred embodiment, implanted device is adapted to be chronically implanted.In another embodiment, implanted device isBioabsorbable implanted device, or the implantation for example disappeared after one or more ablation procedures by evaporationThing.In a preferred embodiment, implanted device may include the proximal portion with the first diameter and the distal portion with Second bobbin diameter,Second bobbin diameter is less than the first diameter and makes the implanted device placement enough in the blood vessels.Implanted device can further comprise positionAnchor part at or near the proximal portion or distal portion of the implanted device, is compared with blood vessel, the anchor partIt is adapted to device being maintained at or near identical position.Anchor part may include hook or barb or this area it is also known that useIn the anything that implanted device is maintained to desired locations.
In a preferred embodiment, implanted device includes resiliency compressible main body, and the main body includes outside triggerable portionAnd it is provided with anchor part.Main body mainly can be made up of wire rod, and can be at expansion or off-position, being provided with narrowed pipeShape shape and/or somewhat flat narrowed tubular form, the i.e. cross section at most positions along the longitudinal axis be ellipse orCircular etc., it is adapted to be placed on inside the arteria renalis.Main body may also comprise circular wire rod between two and five, first compared with great circleShape or oval wire rod, and further comprise with the circular or oval wire rod for reducing diameter, it is mutually positioning and maintain certainIt is at least such when main body is in release or uncompressed position at distance.Main body can be built by the metal wire rod woven (to be had manyIndividual interconnection, intersection and/or layer, it allows many to be connected with the arterial wall of vascular wall or blood vessel).Main body is it is conceivable that to be spiral-shapedWire rod, its diameter is gradually reduced along its longitudinal axis.The winding of implanted device can be connected with each other with the upright Wire rod portion of bridge joint, be carriedFor closed loop to ensure if release device fully and circularly cover such as arteria renalis.Main body, which can be shown, to be bent outwardly and at itBetween still show the longitudinal metal pearls of some interconnection, to ultimately form metal cage.If implanted device is characterized in that, willIt is implanted in the arteria renalis, the ultimate range between two points that can be measured on the circular or oval wire rod of main body will be from 3To in the range of 30mm, more specifically from 5mm to 20mm, or even more specifically from 9mm to 13mm.Its feature of implanted device existsIn if to be implanted in blood vessel, between two points that can be measured on the circular or oval wire rod of implanted device main bodyUltimate range will be in the range of from 5 to 50mm, more specifically from 8mm to 40mm, or even more specifically from 10mm to 30mm.PlantEnter the main body of device mainly can be made up of one or more metal alloys.The main body of implanted device may include by selected from electromagnetism spokePenetrate, directly or indirectly sensing, acoustic energy, mechanical oscillation, heating and/or the energy field for changing the other characteristics of implant or part thereofOr energy field combination and can external trigger part.Some materials for being used in implanted device can have in response to remotely applyingAlternating magnetic field is reacted the type of such as heating.By electromagnetic radiation by external component, by delayed through time-varying magnetic field plusHeat, by directly or indirectly sense and by Joule heating, by sound, mechanical oscillation and chemical energy means, by heat/chemistryOr mechanical/chemical discharges system, energy can be supplied to implanted device.Main body may include the portion being made up of different metal alloyPoint, alternatively with different ferromagnetic properties and/or absorption coefficient, specifically in response to alternating magnetic field.Each portion of main body of implanted deviceDivide can be set and there are one or more coatings with change to attributes.One or more wire rod or implanted device main body other parts byThe different layers that different-alloy and/or other materials are made are constituted.It is further characterized by implanted device, different coating or layer tableShow the different responses for the outside energy field applied, the alternating magnetic field for example applied for outside.With high isolation characteristicRemote cavity-coating layers or layer are provided to implanted device.The main body of implanted device can have self-expandable nature, and this is thanks to using materialThe elastic characteristic of material and the geometry of main body, and when it runs into back-pressure about 10 to 40, it is preferable to 20 to 30, more can be excellentSelection of land 22 to 28, even more preferably about 25mm Hg (be equal to change vascular anatomy required for expansion pressure) when stop intoOne step expands.Implanted device is characterized in that, it is provided with only when being incorporated into the arteria renalis, such as in application external energyThen the noxious material just discharged afterwards, the noxious material produces the lesion of limited necrosis/neurotoxicity.These toxin can be wrappedContain but be not limited to ethanol, tetraodotoxin and bufotoxin, Shandong scorpion toxin, scorpion toxin, charybdotoxin, margatoxin, this sieve poisonElement, plant actinocongestin and He Fu toxin, calcium suppression albumen, safe card toxin, calcium resistance albumen and PhTx3, botulin toxin, relaxationPlain D, rapamycin, sirolimus, Zuo Tamosi, everolimus, taxol, glutamic acid, isoquinolin, N- methyl-(R)-pig hairDish phenol, beta-carboline derivatives.Implanted device is settable micropore, which provides the thing that can be discharged by trigger energyMatter.Implanted device is settable thermal active coating, and it is only activated when temperature is more than 35 DEG C so that body temperature will be triggered and activated.Implanted device is settable thermal active coating, and it is only activated when temperature is more than 45 DEG C so that outside, which will apply energy field, to touchHair activation.Implanted device is settable anchor part, and it is mainly made up of elongated shape and/or expansive force, alternatively with wire rodStructure is combined, it is allowed to which partial insertion is imprinted in the wall of blood vessel, e.g. the arteria renalis.These anchor parts may also include hook orBarb etc., is optionally positioned within the outwardly portion of implant.
In a preferred embodiment, the implanted device includes filled with one or more materials and added in implantThe chamber opened and/or opened when implant obtains body temperature when hot, and/or wherein described implant include coating, the paintingLayer includes one or more materials.
In a preferred embodiment, maximum perimeter and minimum perimeter polygon are included according to the implanted device of the present invention, and it is maximumRatio between girth and minimum perimeter polygon, wherein the ratio is less than 10, it is preferable to less than 9, is more preferably less than 8, veryTo being more preferably less than 7, still more preferably it is less than 6, and more than 1.1, it is preferable to it is more preferably big more than 1.5In 2, even more preferably it is more than 2.5, is still more preferably more than 3.In a preferred embodiment, implanted device include alongThe variable perimeter of implant longitudinal direction, the girth changes between at least 20mm, it is preferable at least 25mm, more preferablyGround at least 30mm, preferably even more at least 36mm, still more preferably at least 42mm, will also more preferably at least48mm, and at most 375mm, more preferably at most 350mm, preferably even more at most 325mm, still more preferably extremelyMany 300mm, will also even more preferably at most 275mm, increasingly even more preferably at most 250mm.Such ratio orSize is necessary, if especially blood vessel is the arteria renalis, it is ensured that the substantive circumference or hurricane band of blood vessel will to.
In particularly preferred embodiments, when self-expanding implanted device is in swelling state, the girth is for exampleAt most the 200% of the blood vessel green diameter that the implanted device of the arteria renalis etc. is adapted to, it is preferable at most 190%, more preferablyGround at most 180%, even more preferably at most 170%, still more preferably at most 160%, will also more preferably at most150%.
In a preferred embodiment, implanted device includes outer surface, and the outer surface includes zigzag or woven or braidingMaterial, trombone slide, eccentric trombone slide, Hollow Pillar, filled with the Hollow Pillar of fluid or its any combinations.
In a preferred embodiment, substantive cylindrical shape is included according to the implanted device of the present invention, its diameter is preferablyIt is at least 2mm, it is preferable at least 3mm, more preferably at least 4mm, preferably even more at least 5mm are still more preferableGround at least 6mm, and at most 20mm, it is preferable at most 16mm, more preferably at most 13mm, even more preferably at most10mm, still more preferably at most 9mm.Such shape or size are necessary, especially in the substantive cylindricality of the blood vesselIn portion, if especially blood vessel is the arteria renalis, it is ensured that the circumference or hurricane band of blood vessel will to.
In a preferred embodiment, distal portion and proximal portion are included according to the implanted device of the present invention, wherein the ablationIn the 50% of the implant total length that region is risen in proximally portion, it is preferable in 40%, more preferably in 30%.In preferred embodiment, distal portion and proximal portion are included according to the implanted device of the present invention, wherein the ablation areas is nearIn the 25mm that sidepiece rises, it is preferable in 20mm, more preferably in 15mm.
In a preferred embodiment, implanted device includes distal portion and proximal portion, and including via described for preventingThe heat-insulated connection of anchor overheat and be connected to the anchor of the implant ablation areas, it is preferable to wherein described anchorIt is fixedly mounted with to put and is connected to distal portion.Anchor may include the materials different from implanted device remainder.Especially, anchorBecause its size, shape or material can have different thermal characteristics.Anchor may be connected to the distal portion of implanted device, with mostIn the inner chamber for being anchored at such as arteria renalis goodly.Heat-insulated connection may include heat-barrier material, or its shape and size can increase everyAnchor is attached to ablation areas by heat, such as many strips or wire rod.
In a preferred embodiment, include above being implemented according to any for treating the system of artery and venous structuresThe implanted device of mode and the excitation used from patient-external or energy are preferably contemplated that after implanted device is provided withAmount provides device, wherein excitation is used for changing the characteristic of implanted device, to treat the artery or venous structures where implanted device.For treating the exciting bank of artery and venous structures it is conceivable that being filled for the implantation with the embodiment described according to any textCooperation is put to use.
In a preferred embodiment, implanted device be implanted into the implanted device when can start to contact with blood samples of patientsPart and the remainder of implanted device be thermally isolated so that encourage implanted device during blood will not be heated or overheat.Such part may include remote cavity-coating layers or the layer with high isolation characteristic.It is evident that being examined for patient's benefit and comfort levelConsider, heating blood should be avoided as much as.
In another embodiment, implanted device includes the core area of the material with a Curie temperature, by being adapted toThe other materials with heat and/or resilient property of the purposes of implanted device are surrounded.In this way, people can be designed by being implanted into dressThe temperature profile put.It should be clear that being intended to by melting contact vascular wall and forming the part of lesion for implant, shouldThis is mainly heated, and is considered for patient health, implant with blood vessel or contacting blood and being not intended to be formed lesion itsIt should partly be received as far as possible low in caloriesly.
In also another embodiment, implanted device includes filled with one or more materials and added in implantThe chamber opened when hot.In a preferred embodiment, these materials be discharged into patient's body or in vascular wall before be mixed,For example for transmitting bi-component neurotoxin.In more preferably embodiment, these materials are one or more following materialsSelection is constituted：
- ethanol；
- tetraodotoxin and bufotoxin；
- Mo Lu scorpion toxins, scorpion toxin, charybdotoxin, margatoxin, this sieve toxin, ground kind actinocongestin or He Fu poisonElement；
- calcium suppression albumen, safe card toxin, calcium resistance albumen or PhTx3；
- clostridium botulinum mycin；
- relaxain D, rapamycin, sirolimus, Zuo Tamosi, everolimus, taxol；
- glutamic acid；
- isoquinolin；
- N- methyl-(R)-salsolinol；
- beta-carboline derivatives.
There is such implant, providing part heating implant by using such as external energy will with desired torqueDesired substance release becomes possibility into vascular wall or blood stream.In addition, the chamber in implant and implant may be designed toSo that two kinds of compositions of such as bi-component neurotoxin are mixed before being discharged into main body.
In a preferred embodiment, one or more toxin deposits are included according to the implanted device of the present invention, preferablyGround is located on the outer surface of described device, and the deposit covered by metal level can be by heating, it is preferable to by stagnantHeat and solve afterwards.
Similar in terms of, the invention provides a kind of implant, including：Circuit, heater line including pick-up loopCircle and the temp control switch including closing position and interruption position.It is described switch preferably include bimetallic devices and/Or thermistor, such as PTC thermistor, and/or the switch preferably include temperature sensor and are preferablyNumeral, including thermostat, when the sensor measures predetermined temperature, the thermostat is connected to the sensor and describedSwitch, to interrupt the switch therefore interrupt the circuit.It may be preferred that the temperature at or near the implant is higher than pre-When limiting ablation temperature, the switch arrangement changes to the open position into from the closing position.In preferred embodimentIn, when the temperature at or near the implant is less than pre-qualified switching temperature, the switch arrangement is opened into from describedPosition, which changes, arrives the closing position.In one embodiment, the ablation temperature is equal to the switching temperature.In another realityApply in mode, the switching temperature is different from the ablation temperature, it is preferable to which the switching temperature is less than the ablation temperature,Such as less than it is described ablation at least 0.01 DEG C of temperature, 0.1 DEG C, 0.5 DEG C, 1 DEG C, 2 DEG C, 3 DEG C, 4 DEG C, 5 DEG C, 6 DEG C, 7 DEG C, 8 DEG C, 9℃、10℃、11℃、12℃、13℃、14℃、15℃、16℃、17℃、18℃、19℃、20℃.In a preferred embodiment, instituteState circuit to switch including more than one, such as 2,3,4 or more switches, it is preferable to be connected in series, for redundancy, that is, be used forEnsure that at least one switching function is as expected.
In an also similar aspect, it is used to block sympathetic renal nerve to believe via ablation by heating the invention provides one kindNumber treat the implant of Arterial Hypertention, including：The LC lines that circuit, heater coil including pick-up loop are temperature dependentRoad, wherein the LC circuits include the resonant frequency of temperature dependency.
Under the influence of the time-varying magnetic flux by the pick-up loop, the pick-up loop of above-mentioned implant is arranged for makingElectric current sensing passes through the circuit being attached thereto.This is arrived, the pick-up loop preferably includes low resistance and high inductance.
It may be preferred that the pick-up loop includes resistance, the resistance is more than 0.02Ohm, it is preferable to be more than0.05Ohm, is more preferably more than 0.1Ohm, is even more preferably more than 0.15Ohm, is still more preferably more than0.2Ohm, will also more preferably be more than 0.3Ohm, also even more preferably be more than 0.5Ohm, and/or less than 30Ohm,Preferably it is less than 30Ohm, is more preferably less than 25Ohm, is even more preferably less than 20Ohm, it is still more preferably smallIn 15Ohm, to be also more preferably less than 10Ohm, 5Ohm, preferably most about 1Ohm are even more preferably less than increasingly.
It may be preferred that the pick-up loop includes inductance, the inductance is more than 0.02 μ H, it is preferable to more than 0.05 μ H,More preferably it is more than 0.1 μ H, is even more preferably more than 0.15 μ H, is still more preferably more than 0.2 μ H, will also more can be excellentSelection of land is more than 0.3 μ H, to be also even more preferably more than 0.5 μ H, and/or less than 30 μ H, it is preferable to less than 30 μ H, more may be usedPreferably less than 25 μ H, are even more preferably less than 20 μ H, are still more preferably less than 15 μ H, to be also more preferably less than10 μ H, are even more preferably less than 7 μ H, preferably most about 4 μ H, such as 1 μ H, 2 μ H, 3 μ H, 4 μ H, 5 μ H, 6 μ H, 7 μ increasinglyH, or any value therebetween.
In a preferred embodiment, the heating coil is arranged to being located in blood vessel, preferably be located in the arteria renalisBasic complete circumference or spiral ablation areas to to obtain substantially complete circumference or spiral shell on the inwall of the blood vesselRevolve signal jam lesion.It may be preferred that the heater coil includes high resistance and low inductance.
It may be preferred that the heater coil includes resistance, the resistance is more than 0.4Ohm, it is preferable to more than 1Ohm,More preferably it is more than 2Ohm, is even more preferably more than 3Ohm, is still more preferably more than 4Ohm, will also be more preferablyMore than 6Ohm, to be also even more preferably more than 10Ohm, and/or less than 150Ohm, it is preferable to less than 100Ohm, more may be usedPreferably less than 80Ohm, is even more preferably less than 60Ohm, is still more preferably less than 50Ohm, will also be more preferablyLess than 40Ohm, 30Ohm is even more preferably less than increasingly, is most about preferably 25Ohm.
It may be preferred that the heater coil includes inductance, the inductance is more than 0.02 μ H, it is preferable to more than 0.05 μH, is more preferably more than 0.1 μ H, is even more preferably more than 0.15 μ H, is still more preferably more than 0.2 μ H, also more may be usedPreferably more than 0.3 μ H, also even more will preferably be more than 0.5 μ H, and/or less than 30 μ H, it is preferable to less than 30 μ H, morePreferably it is less than 25 μ H, is even more preferably less than 20 μ H, is still more preferably less than 15 μ H, it is also more preferably smallIn 10 μ H, 7 μ H are even more preferably less than increasingly, are most about preferably 4 μ H, such as 1 μ H, 2 μ H, 3 μ H, 4 μ H, 5 μ H, 6 μH, 7 μ H, or any value therebetween.
In particularly preferred embodiments, the resistance of heater coil is more than the resistance of pick-up loop, and/or pick-up lineThe inductance of circle is more than the inductance of heater coil.
In a preferred embodiment, such as the time-varying forced is passed through via inductance when for example providing part by external energyMagnetic field come activate flowed through during implant heater coil electric current be more than 0.1A, it is preferable to it is more preferably big more than 0.2AIn 0.3A, even more preferably it is more than 0.4A, is still more preferably more than 0.5A, to be also more preferably more than 0.6A, benefitHair is even more preferably more than 0.7A, to be also even more preferably more than 0.8A, and less than 10A, it is more preferably smallIn 8A, even more preferably it is less than 6A, is still more preferably less than 4A, to be also more preferably less than 2A, increasingly even morePreferably it is less than 1.5A, is also even more preferably less than 1A, is most about preferably 0.9A.
The predetermined temperature of the present invention is preferably the ablation temperature for the blood vessel that implant is placed.It may be preferred thatThe ablation temperature is 37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58th, 59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75 DEG C or between any value.
In a preferred embodiment, the pick-up loop, the heater coil and the institute including the bimetallic devicesTemp control switch is stated to be connected in series, wherein when being heated beyond pre-qualified temperature, the bimetallic devices are in an open position,Thus interrupt the circuit and stop the heating of heater coil, and wherein when at a temperature below the temperature, it is described doubleMetal device is in the close position, thus closes the circuit so that electric current, for example induced-current, can flow through heater lineCircle.
It may be preferred that the implant includes sensing to pick up AC electric currents via the time-varying magnetic field applied from outsideCircuit supplies coil, and the supply coil is connected to AC-DC converter, for providing DC electric current or voltage, it is preferable to coupleTo the switch or other electronic devices of the implant.
In a preferred embodiment, implant includes source circuit and the heater circuit that discretely can be closed and/or open,Wherein described source circuit is arranged for providing D/C voltage and/or electric current output from the AC electric currents of the sensing in the pick-up loop.CanPreferably, the DC outputs are connected to the switch, and energy is provided for the switch.It may be preferred that when the switch is closed,The heater circuit is arranged for heating the heater coil via resistance heating, thus allows heated current to flow through describedHeater coil.
In a preferred embodiment, when the switch is closed, the pick-up loop and heater coil series connection connectConnect, thus allow to flow through the heater coil by the electric current of inductive pick-up by the pick-up loop, from there through resistance plusHeat heats the heating coil.
It may be preferred that the heated current includes AC electric currents, if the switch closure, the AC electric currents can be picked up describedSensed in swash circle and be delivered to the heater coil, and/or the AC electric currents can be all by external energy offer partAs external generator is sensed in the heater coil.The heated current may include DC electric current, be for example provided for byIt is connected to the DC electric current of the supply coil of AC-DC converter.
In a preferred embodiment, implant self-expanding at least in part.In a preferred embodiment, the implantationThing includes cylindrical shape, for implantation into the arteria renalis.
It may be preferred that the pick-up loop includes length, the length is more than 10mm, is more preferably more than 12mm, veryTo 14mm is more preferably more than, still more preferably it is more than 15mm, is also more preferably more than 16mm, also more may be used increasinglyPreferably more than 17mm, is even more preferably more than 18mm increasingly, to be also even more preferably more than 19mm, most preferablyGround is more than 20mm, and less than 95mm, is more preferably less than 90mm, is more preferably less than 85mm, even more preferablyLess than 80mm, still more preferably it is less than 75mm, is also more preferably less than 70mm, to be also more preferably less than increasingly65mm, is even more preferably less than 60mm increasingly, to be also even more preferably less than 55mm, most preferably be less than50mm。
It may be preferred that the pick-up loop includes maximum gauge, and when the implant is in expanding position, the maximumDiameter is more than 10mm, is more preferably more than 12mm, is even more preferably more than 15mm, is still more preferably more than 18mm,Also more preferably to be more than 20mm, 22mm is also more preferably more than increasingly, 24mm is even more preferably more than increasingly,Also even more preferably to be more than 26mm, most preferably be more than 28mm, and less than 70mm, be more preferably less than65mm, is even more preferably less than 60mm, is still more preferably less than 50mm, to be also more preferably less than 40mm, increasinglyAlso more preferably to be less than 35mm, 30mm is even more preferably less than increasingly, to be also even more preferably less than 25mm,Most preferably it is less than 20mm.
It may be preferred that the heater coil includes length, the length is more than 1mm, is more preferably more than 2mm, veryTo 3mm is more preferably more than, still more preferably it is more than 4mm, is also more preferably more than 5mm, most preferably be more than6mm, and less than 30mm, be more preferably less than 27mm, to be also more preferably less than 25mm, increasingly even more preferablyLess than 24mm, to be also even more preferably less than 22mm, most preferably be less than 20mm.
It may be preferred that the heater coil include maximum gauge, when the implant be in expanding position when, it is described mostMajor diameter is more than 2mm, is more preferably more than 4mm, is even more preferably more than 6mm, is still more preferably more than 8mm, alsoMore preferably to be more than 10mm, 12mm is also more preferably more than increasingly, 13mm is even more preferably more than increasingly, alsoEven more preferably to be more than 14mm, most preferably be more than 15mm, and less than 90mm, more preferably be less than 80mm,Even more preferably it is less than 70mm, is still more preferably less than 60mm, is most preferably less than 50mm.
It may be preferred that the implant includes the distance between the pick-up loop and described heater coil, it is described away fromFrom more than 1mm, more preferably it is more than 3mm, is even more preferably more than 5mm, is still more preferably more than 6mm, will also be morePreferably it is more than 7mm, 8mm is also more preferably more than increasingly, 9mm is even more preferably more than increasingly, will also be evenMore preferably it is more than 10mm, is most preferably more than 12mm, and less than 80mm, be more preferably less than 70mm, even morePreferably it is less than 60mm, is still more preferably less than 50mm, is most preferably less than 40mm.
Block sympathetic renal nerve signal dynamic to treat via ablation by heating invention further provides one kindThe system of arteries and veins hypertension, including：Implant, including the circuit including pick-up loop, heater coil and temperature as described in textSpend controlling switch；With at the position of implanted device generate time-varying magnetic field magnetic field generator, wherein it may be preferred that describedMagnetic field generator includes being used to change the orientation feature of the orientation in the magnetic field generated by the generator." orientation for changing magnetic field "Refer to changing the adjoint electromagnetic wave propagation direction of polarization and/or institute of time-varying magnetic field whereby.By using orientation feature, occurDevice can be arranged to provide along the maximum magnetic field of the longitudinal axis time change of pick-up loop, thus effective in the pick-up loopGround induced-current.Orientation feature may include removable and/or rotatable arm or antenna, such as u-shaped electromagnet.CanPreferably, the system includes two implants being such as disclosed above.
In similar aspect, sympathetic renal nerve signal is blocked to control via ablation by heating the invention provides one kindThe system for treating Arterial Hypertention, including：Implant as disclosed in the document, including the related LC circuits of temperature, wherein describedLC circuits include the resonant frequency of temperature dependency；Magnetic field for generating time-varying magnetic field at the position of implanted device occursDevice；Temperature measurement equipment, arranges the resonant frequency for measuring the LC circuits and arranges for humorous by what is be measuredVibration frequency is associated with implantation temperature；Temperature control unit, arranging is used for：
- receive the implantation temperature from the temperature measurement equipment；
- relatively more described implantation temperature and predetermined ablation temperature；
- time-varying magnetic field generated by the magnetic field generator is controlled based on the comparison.
It may be preferred that the system includes two implants being such as disclosed above.
It yet still another aspect, the invention provides a kind of method, for via on the one or more arteria renalis inwalls of ablationSubstantially complete perimeter band or hurricane band treats the patient with Arterial Hypertention by blocking sympathetic renal nerve signal, bagInclude following steps：
- one or more implanted devices are implanted in one or more arteria renalis by sheath and lead, the implantationDevice respectively includes the ablation areas along its length of at least a portion, and the ablation areas is suitable to connect with the arteria renalis surfaceTouch, and the ablation areas at least applies energy to the plant to and with complete perimeter band or hurricane band substantiallyThe signal jam path in the arteria renalis is effectively melted when entering device；
- retraction sheath and lead；
- then provide the ablation areas that part heats one or more implanted devices, the external energy by external energyPart is provided to be spatially separating with implanted device.
In related fields, the invention provides a kind of method, for blocking sympathetic renal god via ablation by heatingArterial Hypertention is treated through signal, is comprised the following steps：
- implantation such as one or more implants disclosed in this document, the implant preferably include pick-up loop,Heater coil and temp control switch, or preferably include the related LC circuits of temperature, wherein the LC circuits are oneIndividual or multiple arteria renalis include the resonant frequency of temperature dependency；
- apply time-varying magnetic field at the position of the implant, thus one or more of implants are heated to pre-Fixed ablation temperature.
It is emphasized that in above method, heating implanted device occurs after surgical procedure.Which improve heatingThe convenience of process and the comfort level of patient.
In similar aspect, the present invention provides a kind of method for heating one, two or more implanted device, and it is fittedConjunction is implanted in one, two or more blood vessel, is comprised the following steps：
- be then act through sheath and lead the implanted device is positioned in the blood vessel, the implanted device respectively includesAlong at least a portion its length ablation areas, the ablation areas at least with complete perimeter band or basic hurricane band substantiallyTo the implanted device effectively melts the endovascular signal jam road when applying energy to the implanted deviceFootpath；
- retraction sheath and lead；
- provide the ablation areas that part heats the implanted device by external energy, the external energy provide part withThe implanted device is spatially separating；
Characterized in that, the heating occurs after the retract sheath and lead, and the institute of the implanted deviceHeating is stated simultaneously to occur.
In the preferred embodiment of methods described, filled prior to providing the one or more implantation of part heating by external energyThe ablation areas put observes the recovery cycle.In addition, the recovery cycle is permanent enough to allow one or more implanted device quiltsBodily tissue outgrowth (overgrown).The recovery cycle also can be permanent enough, whether to test implanted device by good locationAnd do not move substantially in the blood vessels.
The advantage of observation latent period has multiple：Patient has the time to recover from surgical procedure, can be with during latent periodExtra test is performed, to check whether implanted device is well implanted into, bodily tissue can make implanted device outgrowth, thusImprove contact of the implanted device with blood vessel, therefore efficiency of improvement ablation procedure, etc..
In the particularly preferred embodiment of methods described, it is repeatedly carried out with the time interval of appropriate intervals by external energyAmount provides the step of part heats the ablation areas of one or more implanted devices, and the external energy provides part and filled with implantationPut and be spatially separating.
The major advantage of the method presented is, in the case of multiple ablation procedures are necessary, it is not necessary to the second operationProcess, that is, the one or more implanted devices being implanted can reuse in second, third ... ablation procedure.
In the more preferably embodiment of methods described, one or more implantation as described in the publication have been used to fillPut.It is possible thereby to implanted device be designed by designing its shape, size, material composition, magnetic and hot attribute, etc., to produceThe raw effect needed.
Also more preferably in embodiment, the system as described in the publication has been used in methods described.ThisIn the case of, implanted device can be provided part heating by external energy, and can reach the height of implant ablation areas byThe temperature of control.
In a preferred embodiment, at least one implanted device includes the shape suitable for the arteria renalis.
In a preferred embodiment, the blood vessel includes one or more arteria renalis, and the implanted device is describedAblation areas is suitable to contact with the arteria renalis surface and at least with basic hurricane band to described in apply energy toThe signal jam path in the arteria renalis is melted during implanted device.
In the embodiment of methods described, the implant patient vessel to be implanted into using 3D scanning techniques such as CT orMRI is scanned, for example to collect the data of Vascular change diameter when reaching near-end from the distal end of blood vessel.According to these numbersAccording to for example for all two arteria renalis of patient, people can derive the necessary shape and size of implant.This measurement can be withCompleted in the case of no surgical procedure, thus increase the comfort level and health of patient, and reduce medical-risk.ThisAfter measurement, implant can coordinate one or more blood vessels of patient with customized.It is apparent that the implant pair with normal sizeThan implant customized adds the success rate of any medical procedure.
The present invention is further described by following non-limiting example, and the example further illustrates the present invention, and notIt is intended to also should not be construed as limiting the scope of the present invention.
Example
Fig. 1 a-1c represent the preferred embodiment of the implant 1 according to the present invention, with circular cross section (Fig. 1 b) and ellipseCircular cross section (Fig. 1 c).It should be clear that in other figures of implant embodiment are shown, cross section can alsoIt is circular or oval, or coordinates the substantially any other shapes for the blood vessel to be most preferably implanted into.
The implant 1 of expression includes main body 2, in this case, is configured to narrow tubulose cage and by the grade system of metal wire rod 3Into being adapted to be placed on inside the arteria renalis.
More particularly, main body 2 is provided with three circular wire rods in this case：In first large round wire rod 4, centreThe circular smaller round wire rod 6 of wire rod 5 and the 3rd of the second of type.
But, the appearance of main body 2 is settable more or less than three rings, more specifically such as two to five, threeTo four, or even more than five rings.
First large round wire rod 4 is by oblique straight and upright Wire rod portion 7 in this case for three and centreThe circular wire rod 5 of type second is connected.
In a similar manner, the middle medium-sized second circular wire rod 5 is by also oblique straight and upright for three in this caseWire rod portion 8 be connected with the 3rd smaller round wire rod 6.
Wire rod portion 8 is located relative to the centre position of Wire rod portion 7 herein.
Result is narrowed tubulose cage, it is also possible to be described as the main body 2 of main taper or funnel shaped, be provided with each other withThree circular wire rods of certain distance positioning, it is at least such when main body 2 is in release or uncompressed position.
Put it briefly, self-expanding main body 2 is preferably provided with the shape for coordinating vein such as renal artery dissection.
According to preferred embodiments, circular wire rod is settable main elliptical shape so that main body 2 by convergence diameter notBuilt with elliptical ring, be ideally suited for the dissection of the arteria renalis.
The representative diameter scope of these rings of main body 2 is from 3 to 30mm, specifically between 5mm and 20mm, even moreSpecifically between 9mm and 13mm.
The typical range of these rings of main body 2 is from 5mm to 50mm, more specifically from 8mm to 40mm, or even specifically inBetween 10mm and 30mm.
Thanks to the elastic characteristic for using material, and thanks to the geometry of main body 2, main body 2 has self-expandable nature.
If it is desired that with metal, then it can be based on Nitinol, known to because of its remarkable self-expandable nature.
When the pressure that it runs into is about 1 to 150mm Hg, more specifically 3 arrive 80mm Hg, and more specifically 5 arrive60mm Hg, more specifically 10 arrive 40mm Hg, and it is equal to the expansion pressure required for change renal artery dissection, self-expanding main body2 are contemplated to stop expansion.
Alternatively, it is contemplated that self-expanding cage, there is the ring of the interconnection of different circular or elliptical shapes.Ring may be formed such thatSpiral form is formed.The different rings of spiral also will interconnection so that during heating or from cage during h substance, not used for electricityThe opening of gas signal cycle is left opening.
In this case, used material has to react in response to the alternating magnetic field remotely applied and for example addedThe type of heat.
Depending on the absorption properties for the metal alloy for building main body 2, delayed principle causes metal in cage to be heated.
Alternatively electromagnetic field generator, its delayed heating for changing polarity and therefore inducing the material being put into inside field.Curie temperature (temperature that a certain material can be heated to, further energy transmission that some materials are possessed can be used in systemNo longer change temperature), until the target temperature that should and can be reached.For example, zinc ferrite (ZnFe2O4) it is Curie temperature 30And the material between 45 degrees Celsius.
Therefore the metal alloy cage that its structure includes zinc ferrite can accurately be heated to 45 degree, close to expect to be used for suitablyMelt the target temperature of purposes.
Another replacement for transferring the energy to cage is probably direct sensing, using magnetic core, reuses delayed heatingBut use more direct mode.
Transfer the energy to cage another replacement may be by heat chemistry release system electromagnetism is used with external triggerRadiation, wherein chemicals are only discharged into demand and suitable position.
It is evident that can apply still for substitute energy field, such as electromagnetic radiation, delayed heating, reach Curie temperature,Direct sensing, heat/chemical delivery system, mechanical/chemical release system, indirect sensing, Joule heating, acoustic energy, mechanical oscillation,Chemical delivery system.
Alternatively, main body 2 can be provided with only being incorporated into the arteria renalis release, for example after external energy is appliedThen the noxious material of release, the noxious material produces the lesion of limited necrosis/neurotoxicity.
In Fig. 2 a-2b, the alternate embodiments of the implant 1 according to the present invention are represented.
Main body is built by the metal wire rod 9 of the braiding with multiple interconnection, intersection and layer.It is this to repeat to allow and Renal vascularOr other walls produce many connections.
In figures 3 a-3b, implant 1 is contemplated that spiral-shaped wire rod 10, and its diameter is gradually reduced along its longitudinal axis.
Winding 10A-10D, is in this case four, is connected with each other with the upright Wire rod portion 8 of bridge joint.
It is in place of the embodiment that therefore embodiment represents different from such as Fig. 1 a-1c, single or continuous helical shapeWire rod replace different circular wire rod 4-6.
The upright Wire rod portion 8 of bridge joint, except the given structure and intensity to implant 1, also provides closed loop.
Really, different winding 10A-10D are still interconnected, to ensure once device is released, fully circular lesion hairLife is in the arteria renalis.
In Fig. 4 a-4b, implant shows the longitudinal metal pearl 11 being bent outwardly, still show between them it is some mutuallyEven, to ultimately form metal cage.
The part being made up of different metal alloy may include according to the implant 1 of the present invention, it is alternatively specific in response to handing overVarying magnetic field has different ferromagnetic properties and/or absorption coefficient.
Alternatively, the basic structure of implant 1 can be made up of same material, and the coating for having attribute change can be set in itPortion.
Fig. 5 embodiment illustrated shows to be contemplated that the implant of spiral-shaped wire rod 10, its diameter along its longitudinal axis byGradually decline, but in the place relative with the embodiment that Fig. 3 a-3b are represented, winding 10A-10E is in this case five,It is connected with each other by the upright wire rod 12 of bridge joint, the upright wire rod 12 of bridge joint extends up to minimum winding from maximum winding 10A10E。
The maximum winding 10A of implant 1 is built by the metal alloy of self-expandable nature, and covered with minimum ferromagnetic properties100 metal level.
Next winding 10B by identical self-expanding alloy build, covered with during hysteresis S. E. A. it is higherMaterial layer, therefore change magnetic field will show different heating attributes 200.
The winding 10D and 10E positioned at maximum winding 10A farthest sides, in a part for the arteria renalis, is provided with delayed existingAs the material layer of period S. E. A. still higher 400.
According to another embodiment of implant 1, one part is schematically shown in figure 6, is built implant 1 and is ledThe wire rod of body 2 is made up of different layers, three layers be made in this case for different-alloy 15,16 and 17.
These different-alloys are in contact with each other, and depending on the different magnetic field to be applied, different attribute will be presented in they.
It is evident that being alternative in or being combined with above-mentioned or further feature, one or more layers can have high heat-insulated spyProperty, heat is directed to the place of needs, and isolate each portion to prevent unexpected blood or tissue heating.
According to another embodiment of implant 1, one part is schematically shown in the figure 7, and main body 2 is provided with micro-Hole 18, micropore 18 is located therein setting the nearly chamber side 13 (being contrasted with remote chamber side 14) of material.
Such material can be for example selection or the composition of one or more following materials：
- ethanol；
- tetraodotoxin and bufotoxin；
- Mo Lu scorpion toxins, scorpion toxin, charybdotoxin, margatoxin, this sieve toxin, plant actinocongestin or He Fu poisonElement；
- calcium suppression albumen, safe card toxin, calcium resistance albumen or PhTx3；
- clostridium botulinum mycin；
- relaxain D, rapamycin, sirolimus, Zuo Tamosi, everolimus, taxol；
- glutamic acid；
- isoquinolin；
- N- methyl-(R)-salsolinol；
- beta-carboline derivatives.
When main body is coiled in together, such as, prior to being arranged in guiding catheter system, micropore 18 is closure；And releasingWhen being put into its terminal position, based on expansion, these micropores 18 are opened so that the material inside cage metal arm can discharge.
According to another embodiment of implant 1, one part is schematically shown in fig. 8, main body 2 is by thermal activitiesCoating 19 is covered, and thermal active coating 19 is only activated when temperature is more than 35 DEG C so that body temperature will trigger activation.
Alternatively, thermal active coating 19 can be set, and it is only activated when temperature is more than 45 DEG C so that outside applies energyField will trigger activation.
Alternatively, heat-barrier material 44 can be arranged on implant with main body preferably non-heating part, such as blood vesselWall or blood some parts start at the part of contact.Whereby, implant be heated portion of it is heat-insulated with such as blood.
Energy field may be, for example, the alternating magnetic field remotely applied, and the main body 2 of implant 1 is heated thanks to hysteresis effect.
Under the activationary temperature, coating 19 is absorbed, and the active device remained in below coating 20 is discharged into blood vesselIn wall or arterial wall.
It is noted that elongated shape and/or expansive force provide the anchor part that may be considered as implant 1.
Alternatively, hook or barb etc. 29 can as being arranged in fig. 11 in the outwardly portion of implant 1, once it putsThe anchoring ensured can be provided for implant 1 in place.
According to or another embodiment, outer shroud or other basket structures be installed in blood vessel, or whole cage can be equipped withOne structure is to increase the reliability that cage is motionless, to determine the fixed position of implant, to reduce the motion of implant after the implantationPossibility.
The method for placing implant is easy, and can be performed as described below.
According to known practice, conduit 30 and lead 31 are introduced into, the position being left until implant 1.This is in Figure 12With 13 in be schematically shown.
Retract conduit and implant 1 is left into correct position can cause implant 1 to expand.
Because the shape and/or elastic characteristic of implant 1 are suitable for coordinating and being alternatively pressed against artery or venous structuresOn, for example, arteria renalis, so leaving implant 1 in the way of self grappling by safety.
After conduit is fully retracted, implant 1 is fully discharged.
Alternatively, air bag expansion known to can applying.
The suitable cycle can wait prior to applying external energy, to trigger the triggerable portion of implant 1.
It is contemplated that the various continuous treatments by simply applying suitable energy field, without performing the minimal invasive procedures updated,This is the major advantage according to implant and system of the invention.
In addition, in the case where implant 1 sets and changes minor structure, wherein each energy applied in response to outside, it may be considered that the treatment of change, such as by increase intensity.
The alternating magnetic field for the long-range application that can have specific frequency with characterizing for example triggers each part.
It is evident that when with reference to lesion, these can pay close attention to the transmural lesion for extending up to exterior wall, and with it is discrete orComparatively, lesion can be continuous to the parts of lesions of composition.
The present invention is not limited to the embodiment that citing description and accompanying drawing are represented；Conversely, being used to treat dynamic according to the present inventionThe system of the such implant and implant and exciting bank of arteries and veins and venous structures can be made in all categories shape andAmong size, and remain in that within the scope of the invention.
Fig. 9 shows circular braiding implant 21, and one of circumferential zones 22 include the conjunction with a specific Curie temperatureGold, and the second circumferential zones 23 include the alloy with another specific Curie temperature.
Figure 10 shows the implant 24 of funnel shaped braiding, and one of circumferential zones 25 include having specific Curie's temperatureThe alloy of degree, the second circumferential zones 26 include the alloy with another specific Curie temperature, and the 3rd circumferential zones 27 includeAlloy with another specific Curie temperature.
Figure 11 shows the implant 28 of funnel shaped braiding, the anchor part 29 with small fashion of barbs.
Figure 13 shows how catheter tip is guided for example by way of inserting vein or the artery arrival such as arteria renalis 38.
Figure 14 represents that external energy provides the embodiment of part 42, and it can be used for treatment during ablation procedure 43 and suffers fromPerson.
Figure 15 shows the implant in correct position 40 and the zone of ablation in blood vessel in cone section cross section 41Domain.
Figure 18 shows another embodiment of implant, and it has hourglass shape 45, wherein in diameter becomes smallerBetween areas adjacent, a set of heating ring 46 is attached at around implant hourglass shape part.Heating ring is attached to sand in heat-insulated modeLeak shape part so that have seldom heat transfer to blood stream when heating ring and being heated.In addition, heating ring is intended to and the bloodStream is kept completely separate, because hourglass shape part can be by blood viscousness tissue coverage, and can be pressed from both sides at or near implantation end 47 and 48It is tightened in blood vessel.
Figure 19 shows to include the embodiment of the implant of fuse so that at a certain temperature, specifically in realityAt a temperature of existing optimal ablation reaches, between 40 and 80 degrees Celsius, between 45 and 60 degrees Celsius, it can generateCircuit be interrupted.This derives from following phenomenon：Work as implant, more specifically metal implant, more specifically NitinolWhen implant is brought to alternating magnetic field, generation electric current by metal implant in itself, therefore by itself generation accelerate heating (senseShould and Joule heating).The phenomenon causes extremely rapid to heat implant, and this can be by the way that interrupt can be by the electric current of implantAnd stop.The stopping of this electric current can be caused by the fuse in metal implant, and for example may be present when heatingThe resistance of open circuit during more than certain temperature.In this case, fuse will stop further being heated beyond the temperature of 45-60 degreeDegree, more specifically 50-55 degree.Figure 19 a show the detail view of fuse.
In different configuration, as shown in Figure 20, metal implant can be built by marmem so that in heatingDuring device, another construction is occupied in different metal part, and thus interrupting can be by the electric current of implant.Switch or fuse are openedShown in figs. 20 a and 20b respectively with the details of closed position.The different construction opened is potentially by the original of metalForm is constituted so that it is returned to its " shape memory ".This is referred to as " shape memory metal ".
In still different constructions, as shown in Figure 21 and Figure 21 a details, implant is by two kinds of different materials groupsInto both different materials can be interrupted in the contact between heating two kinds of different metals, and implant is passed through to stop electric current.
Another part of behaving excellently of this application is that heating needs to be unidirectional.Blood needs to isolate with heating, for followingTwo reasons：First, blood should not be heated, because the protein in blood can be denatured and form grumeleuse；Second, becauseBlood is huge heat dissipator, can subtract excessive heat away from implant, it will need excessive power to make implantAblation areas reaches preferred temperature.Therefore, wide coating formation is complete remote as shown in Figure 22 around implant, but almostChamber side so that when implant is heated, dissipated without heat towards blood stream.
Figure 23 illustrates idea of the invention, and wherein implanted device (55) is provided with built-in thermal switch (54).Whereby, it is described to plantEntering thing can be by applying time-varying magnetic fieldAnd activate, the radio frequency that can be for example produced by electromagnet or magnet coil or antenna (51).If the switch (54) is closure, the time-varying magnetic fieldElectric current can be induced in the circuit, by describedPick-up loop (53) and the heating coil (52).Switch is closure or opening, depending at the position of the switch or temperatureSensor is attached to the temperature at position of the switch (preferably via thermostat).
Figure 24 diagrams implant is in the size of expanding position in the blood vessel.Whereby, blood vessel (65) typically ranges between 5mm extremely50mm is wide, such as 20mm diameter.Heater coil (62) can about 20mm length, and pick-up loop (63) can be with, and can be excellentSelection of land, is longer than 20mm.Figure 24 thermal switch (64) is positioned near heater coil (62), and depending on the heater lineTemperature at or near circle and open or close.Circumferential ablation of the heater coil with blood vessel in heater coil whole lengthRegion to.
The different embodiments of Figure 25 a-g diagram present invention, the shape of its coil and absolute and relative big I existIt is different between different embodiments.Heater coil (72) and pick-up loop (73), which can understand, to be assert, the pick-up loop of presentation(73) a large amount of windings are included, to increase their inductance.Thermal switch (74), is attached to printed circuit board (PCB) (pcb) in Figure 25 a-eAnd be applied, it is connected to heater coil (72) and pick-up loop (73).In Figure 25 d-g, including one or more electronics electricityThe pcb (75) on road may include thermal switch, and/or supply lines coil is connected to pick-up loop (Figure 25 f-g) or switch (figure25d-e).The shape of coil can be arranged to be installed in specific blood vessel, such as cylindricality vein or artery (Figure 25 a) or coneShape vein or artery (Figure 25 b-g).Particularly directed to the arteria renalis, for the cylinder shape heater coil being implanted in arterial lumensIt is preferred.
Temperature profile (77) of the winding of heater coil (76) when activating implant in the wall (78) of induction blood vessel.ThisIt is illustrated in Figure 26, Figure 26 diagrams, heat is mainly deposited near winding, and the outside of blood vessel (79) can also be heated to oneIncrease temperature.Suitable modeled blood vessel and mechanism for testing allow optimum temperature of the setting for implant, with ablation vesselsThe signal jam path of wall, without unnecessarily damaging the tissue that remain intact.
Other embodiment including such as PTC (80) or thermistor switch is illustrated in Figure 27 a-b, for substantive postThe implant of shape.
In some embodiments, it is necessary to or suggestion uses the electric device for needing to operate DC electric current or voltage.At thisIn the embodiment of sample, it is necessary that implant includes AC-DC converter, and implant at least one will be flowed through via sensingThe AC electric currents of part circuit are converted into DC electric current.The converter can obtain AC input electricity from pick-up loop or supply lines coilStream.Such converter can be attached to the larger electronic circuit for the coil that pcb (81) is connected in parallel to as shown in Figure 28A part.
Figure 29 a-29f illustrate electronic circuit, and it can be used in the embodiment of implant of the present invention.If high currentHeater wire or heater coil are sent through, then the temperature around heater coil generation heat, and heater coilDegree rises.If without electric current by heater coil, because making temperature drop inside cooling blood stream.For ablation,Target temperature near 55 DEG C can need to reach and be kept for the regular hour measure.Digital thermostat PCB (IC1) is by TEMPDevice measurement temperature, and the high current by heater coil is switched to opened or closed by switch (IC3), heating is forced wherebyTemperature near device coil rises or falls.Heater coil provides dynamic by the energy sensed in big pick-up loopPower.Control circuit provides power by the coil separated.
Temperature sensor measurement internal temperature, and it is compared with 55 DEG C under 2 DEG C of hysteresis curves.If tested amount temperatureHigher than 55 DEG C, then the chip provides high output voltage level (5V)；If temperature is less than 55 DEG C of target temperature, provide low defeatedGo out voltage level (0V).Carry out controlling switch (IC3) using the thermostat chip (IC1), it is to have to integrate in this casePhotoelectrical coupler solid-state relay (SSR) because the SSR allows hand over the alternating current sensed by pick-up loop.Due toThe switch (IC3) needs to provide (thermostat chip can have low-down output current driving force) than temperature sensorBigger electric current, it is necessary to use buffer.Because high switcher input voltage causes closure state and low voltage causes to beatOpen state, the buffer is realized by the inverter (IC2) with big output current.Switch (IC3) and inverter (IC2) itBetween such as 330Ohm resistor (R1) limit switch driving current, whereby protection switch input.The chain (Figure 29 b) provides temperatureControl.Because the chain is made up of active device, this only can work in the case where being sufficiently fed.Figure 29 a chain provide byThe 5V service voltages output of the stabilization of the input AC voltages of the circuit supply coil transmission of separation.The coil provides specific power chain and neededThe more low AC voltages wanted.Input AC voltages are transformed into D/C voltage by half-wave rectifier (D1), higher than target 5V.Then 5V lines are usedProperty adjuster (IC4) voltage is transformed into stable 5V power supplys.The electric capacity for entirely designing visible such as 100nF is placedCouple (local stability of service voltage).
Symbol GND, VAC and 5V respectively represent net value, with identical name bound symbol.These do not have other physical meanings,Only it is another connection.GND is the conventional sign (because all voltages are required to some points inside reference line) of Voltage Reference.This should not be erroneously interpreted as ground connection.GND is ordinarily selected to be attached with low-down impedance, therefore is typically implemented as with reference to flatFace.
Connector CON1 is heater coil (pEnter1), circuit supply coil (pEnter2) with Voltage Reference GND (pEnter3) connectMouthful.
Another embodiment of circuit is shown in Figure 29 c-d.The plate is smaller style, is used as what is presented in Figure 29 a-bOne.Feature is consistent, but it is used compared with gadget.Adjuster (IC4) is different, and is switched and resistor-junctionSynthesize a device (IC3).In addition, big connector changes over connector CON1-CON3 three smaller.Extra company can be usedMeet device CONVCC, CONGND and CONTGo outPlate is divided into platelet with temperature sensor and with the another of chip remainderPlate.So, small temperature sensor can be taken to closer to heater coil.
In Figure 29 a-29f, it is illustrated that according to the embodiment of the implant of the present invention, wherein implant includes separationCoil is supplied, other devices are provided with special supply lines, such as thermostat, inverter and constant DC voltage is for example5V switch, as shown in Figure 29 e.In the other embodiment of the implant according to the present invention, centre cap (centerTap) it can be used in pick-up loop side, to obtain the line power coil (Figure 29 f) that line power replaces separation.This seems to be more easy toIn being integrated in implant instead of using tertiary coil.The latter embodiment can cause following additional problem：Centre cap canIt is placed in inside switch chain.If big electric current flows through coil combination, the magnetic field cancellation of electric current generation falls to actually result in the electricityThe external magnetic field of flowing.This causes the voltage drop across coil terminals.This means in the case of closure switch, cross spanThe voltage for enclosing terminal can be more much lower than opening the situation of switch.The voltage difference may cause adjuster to lose due to high power consumptionEffect.In order to solve the problem, it is necessary to add additional devices to circuit to prevent this problem.Such device can be added for example micro-In cake core design.
Figure 30 a-34 diagram external energies provide the embodiment of part, and it can be used in the system or method of the present inventionIn, for supplying energy to implant by providing time-varying magnetic field in implantation object location.
Figure 30 a-b and Figure 33-34 illustrate an embodiment, wherein the patient with implant can during heating processSit down, because time-varying magnetic field is preferentially produced in the arched arm (90) of generator (91).Arm can rotate, it is preferable to around transverse axis(92) rotate, and patient's chair (93) is also rotatable, it is preferable to rotate, and can move up and down around vertical pivot so that occurReached between induction field in device magnetic field and implant it is optimal inductively.The optimum position of generator may depend on patient,And the orientation of the treated blood vessel of patient.Therefore generator is as illustrated in these figures, wherein the orientation and size in magnetic fieldBoth can change over time, and be particularly preferred in the system and method that the document is presented.
Figure 31 is shown in the possibility using big magnetic field generator (91) around estrade (94), and patient can lie in estrade(94) treatment is received on.Estrade can flatly be moved through generator.
Figure 32 a-b diagram magnetic field generators (91), it can generate the field of different orientation, wherein most preferably sensing implantIn electric current orientation be adapted to patient dependence mode.
The invention is not restricted to previously described any way of realization, and some modifications can be added to presented manufactureExample, without being reappraised to appended claims.For example, the present invention is described with regard to the arteria renalis, but it is brightIt is aobvious, for example, the present invention can be applied to other blood vessels.
The present invention pays close attention to but is not limited to：
1. for the method that heats one, two or more implanted device, the implanted device be adapted to be implanted in one,In two or more blood vessels, comprise the following steps：
- be then act through sheath and lead the implanted device is positioned in the blood vessel, the implanted device respectively includesAlong at least a portion its length ablation areas, the ablation areas at least with complete perimeter band or basic hurricane band substantiallyTo the implanted device effectively melts the endovascular signal jam road when applying energy to the implanted deviceFootpath；
- retraction sheath and lead；
- provide the ablation areas that part heats the implanted device by external energy, the external energy provide part withThe implanted device is spatially separating；
Characterized in that, the heating occurs after the retract sheath and lead, and the institute of the implanted deviceHeating is stated simultaneously to occur.
2. according to the 1st point of method, wherein, at least part of each implanted device by display magnetic hysteresis at least oneMaterial is made, such as ferromagnetic, Ferrimagnetic or anti-ferromagnetically material.
3. according to the 2nd point of method, wherein, the implanted device includes iron content fluid.
4. according to the method for the 1st to 3 any point, wherein, heating provides part, the external energy by external energyAmount provides part and time-varying magnetic field is formed at the position of the implanted device.
5. according to the method for the 1st to 4 any point, wherein, at least one of the implanted device includes thermal active coating,The thermal active coating includes the activationary temperature between 35 DEG C and 37 DEG C so that body temperature will be triggered and activated.
6. according to the method for the 1st to 4 any point, wherein, at least one of the implanted device includes thermal active coating,The thermal active coating includes the activationary temperature more than 45 DEG C so that activation is only carried in the ablation areas by the external energyTriggered when being heated for part.
7. according to the method for the 1st to 6 any point, wherein, the implanted device include producing limited necrosis and/Or the material of the lesion of neurotoxicity.
8. according to the 6th point of method, wherein, at least one of the implanted device includes chamber, and the chamber is filled withThe material and implant be heated when open.
9. according to the method for the 6th to 8 any point, wherein, at least two materials are mixed before release, for example, passSend bi-component neurotoxin.
10. according to the method for the 6th to 9 any point, wherein, the material be one or more following materials selection orComposition：
- ethanol；
- tetraodotoxin and bufotoxin；
- Mo Lu scorpion toxins, scorpion toxin, charybdotoxin, margatoxin, this sieve toxin, ground kind actinocongestin or He Fu poisonElement；
- calcium suppression albumen, safe card toxin, calcium resistance albumen or PhTx3；
- clostridium botulinum mycin；
- relaxain D, rapamycin, sirolimus, Zuo Tamosi, everolimus, taxol；
- glutamic acid；
- isoquinolin；
- N- methyl-(R)-salsolinol；
- beta-carboline derivatives.
11. according to the method for the 1st to 10 any point, wherein, at least one implanted device includes the shape suitable for the arteria renalisShape.
12. according to the method for the 1st to 11 any point, wherein, the blood vessel includes one or more arteria renalis, and instituteState implanted device the ablation areas be suitable to the arteria renalis carry out surface contact and at least with basic hurricane band to,For melting the signal jam path in the arteria renalis when applying energy to the implanted device.
13. according to the method for the 1st to 12 any point, wherein, heat one or many prior to providing part by external energyThe ablation areas of individual implanted device and observe the recovery cycle, wherein the recovery cycle can be permanent enough, to allow implantation to fillPut and be incorporated into vascular wall.
14. according to the method for the 1st to 13 any point, wherein, it is repeatedly carried out with the time interval of appropriate intervals by outerPortion's energy provides the step of part heats the ablation areas of implanted device, and the external energy provides part and implanted device spaceSeparation.
15. a kind of self-expanding implanted device, is suitable for implantation into and disposes in the blood vessels, the implant is included along at least oneThe partly ablation areas of its length, ablation areas is suitable to carry out surface with blood vessel to contact, and suitable at least with it is substantially completePerimeter band or hurricane band are to and the ablation areas is when applying energy to implanted device effectively in ablation vesselsSignal jam path.
16. according to the 15th point of implant, wherein, the ablation areas includes at least one material of display magnetic hysteresis, allSuch as ferromagnetic, Ferrimagnetic or anti-ferromagnetically material.
17. according to the 16th point of implant, wherein, the implanted device includes iron content fluid.
18. according to the implant of the 15th to 17 any point, including thermal active coating, the thermal active coating includes 35 DEG CAnd the activationary temperature between 37 DEG C so that body temperature will be triggered and activated.
19. according to the implant of the 15th to 17 any point, including thermal active coating, the thermal active coating includes exceeding45 DEG C of activationary temperature so that activation is only triggered when the ablation areas provides part heating by the external energy.
20. according to the implant of the 15th to 19 any point, including limited downright bad and/or neurotoxicity can be producedThe material of lesion.
21. according to the 20th point of implant, including chamber, the chamber is added filled with the material and in implantOpened when hot.
22. according to the 20th or the implant of 21 any points, wherein, the material is mixed before release, for exampleTransmit bi-component neurotoxin.
23. according to the implant of the 20th to 22 any point, wherein, the material is the choosing of one or more following materialsSelect or constitute：
- ethanol；
- tetraodotoxin and bufotoxin；
- Mo Lu scorpion toxins, scorpion toxin, charybdotoxin, margatoxin, this sieve toxin, plant actinocongestin or He Fu poisonElement；
- calcium suppression albumen, safe card toxin, calcium resistance albumen or PhTx3；
- clostridium botulinum mycin；
- relaxain D, rapamycin, sirolimus, Zuo Tamosi, everolimus, taxol；
- glutamic acid；
- isoquinolin；
- N- methyl-(R)-salsolinol；
- beta-carboline derivatives.
24. according to the implant of the 15th to 23 any point, including the shape suitable for the arteria renalis.
25. according to the 24th point of implant, wherein, the ablation areas of the implanted device is suitable to and the arteria renalisCarry out surface contact and at least with basic hurricane band to.
26. according to the implant of the 15th to 25 any point, including maximum perimeter and minimum perimeter polygon and maximum perimeter andRatio between minimum perimeter polygon, wherein the ratio is less than 7 and more than 3.
27. it is described according to the implant of the 15th to 26 any point, including along the variable perimeter of implant longitudinal directionGirth changes between at least 36mm and at most 250mm.
28. according to the implant of the 15th to 25 any point, including substantive cylindrical shape, the substantive cylindrical shape includesAt least 5mm and at most 10mm diameter.
29. according to the implant of the 15th to 28 any point, including distal portion and proximal portion, wherein ablation areas positionIn proximally portion within the 50% of implant total length.
30. according to the implant of the 15th to 29 any point, including distal portion and proximal portion, wherein ablation areas positionIn 15mm in proximally portion.
31. according to the implant of the 15th to 30 any point, including distal portion and proximal portion, and including anchor,The anchor is connected to the ablation areas of the implant via heat-insulated connection, to prevent the mistake of the anchorHeat, wherein the anchor is connected to distal portion.
32. a kind of system, including one, two, three, four or more according to the implantation of the 15th to 31 any pointDevice.
33. providing part according to the 32nd point of system, including external energy, the external energy provides part and planted with describedEnter device to be spatially separating, and the implanted device can be supplied energy to, with the temperature for the ablation areas for increasing implanted deviceUntil ablation temperature.
34. according to the 32nd or the system of 33 any points, including：
- sheath, is adapted to one or more implanted devices be transported and are sent to the expectation in one or more blood vesselsPosition or near；And
- lead, is adapted to the sheath with one or more implants being directed to successively in one or more blood vesselsDesired locations.
35. according to the system of the 32nd to 34 any point, including one or two is according to the plant of the 15th to 34 any pointEnter device, each implanted device is suitable to the corresponding arteria renalis.