Ink vessel transfusing blood pressure pressure measxurement seal wireTechnical field
The present invention relates to technical field of medical instruments, a kind of intravascular pressure measurement particularly relating to use in blood vessel intervention operation setsStandby.
Background technology
Coronarography and intravascular ultrasound are regarded as " goldstandard " of diagnosis of coronary heart disease, but they can only be narrow to pathological changesDegree carries out imaging evaluation, and narrow that Distal blood flow creates much impacts (functional evaluation) on earth is unknown；AndThe method of these morphological images does not identifies the pathological changes causing patient's myocardial ischemia, it is also possible to over-evaluate or underestimate the serious of pathological changesDegree, the pathological changes causing needs to be treated does not processes or excess processes be not required to treatment pathological changes.Nico Pijls in 1993 etc. 1 carryGo out the New Set blood flow reserve mark (Fractional Flow Reserve, FFR) being calculated coronary blood flow by piezometry.WarpCrossing long-term basic and clinic studies, FFR has become as the generally acknowledged index of coronary stenosis Evaluation of Functional.
In vascular surgery, particularly in insertion type heart arter vascular surgery, therefore it is highly desirable to endovascular blood pressure fixed point is enteredThe measurement that row is real-time, in order to accurately know the situation of blood, helps doctor to judge the degree whether blood flow is obstructed and is obstructed exactly,To determine the need for performing the operation further.The currently used device for arteria coronaria measurement is pressure measxurement seal wire, and general external diameter is0.36mm, is to be provided with a pressure transducer at the far-end of guiding wire, obtains live body by the pressure signal of pressure transducerThe blood pressure of interior blood vessel also calculates FFR value in order to assess the blood flow levels of blood vessel.
Clinically, the assessment of pressure measxurement seal wire is mainly reflected in accuracy and the stability of measurement, the propelling movement ability of seal wire itselfAnd seal wire passes through the ability of bending pathological changes.In terms of the accuracy and stability of measurement data, they are more lays particular emphasis on Pressure wireThe bending resistance showed during pushing and during use.Pressure measxurement seal wire product mainly takes following two to set at presentSensor chip installed by meter, in order to the elimination part flexural deformation impact on sensor chip:
1. sensor design is become the installation pedestal of a sideband raised structures, pedestal is installed and is directly fitted together with core filaments, and senseDevice chip area and core filaments directly form the impact that chip is produced by a space to the deformation alleviating heart yearn.Pass yet with pressureThe dimensional problem of sensor, the chip base processing technique difficulty of projection is very big, needs higher cost.
2. the region that core filaments connects with sensor is designed to the platform of unilateral band projection, and sensor retains planar design, makes bothDuring assembling, produce certain gap, avoided by this gap causing sensor chip to deform because core filaments deformsAnd produce measurement error.But due to size, the most limited glue amount can only be smeared between chip and core filaments bossing and consolidateBoth fixed, it is moved because intensity is the highest during may result in use.
Summary of the invention
The invention aims to overcome the deficiencies in the prior art to provide one can measure Ink vessel transfusing blood pressure in real time and provideWhile well propelling movement property and torsion control power, it is possible to obtain the measurement seal wire of more accurate measurement data.
For reaching above-mentioned purpose, the technical solution used in the present invention is: a kind of Ink vessel transfusing blood pressure pressure measxurement seal wire, and it includes:
Far-end pipe shaft, described far-end pipe shaft include far-end that internal core filaments, fixed cover be located on described internal core filaments front end around spring,Be arranged on the pressure transducer in described internal core filaments middle-end, retainer ring be located at described pressure transducer with corresponding inside in core filamentsWire that developing ring welds mutually with described pressure transducer and be fixedly installed on described inside core filaments part elongated endFar-end outer tube；
Near-end pipe shaft and linkage section part, described near-end pipe shaft includes that near-end outer tube, described linkage section part include dead ringAnd the conducting ring coaxially connected with described dead ring, the elongated end of described inside core filaments and described wire sequentially pass through describedNear-end outer tube, dead ring and conducting ring, and described wire end is connected with described conducting ring formation conductive path；
Described far-end pipe shaft, near-end pipe shaft and linkage section part are coaxially disposed；
Being positioned at the inside core filaments of described developing ring in " convex " font, being positioned at the described uppermost plane definition of " convex " font isSupporting surface, is positioned at described supporting surface both sides and is buffering suface less than the plane definition of described supporting surface, described pressure transducerBottom surface is the plane paralleled with described supporting surface and load is located on described supporting surface, and described pressure transducer delays with both sidesSoft-medium and hard medium it is separately filled with between impulse face, and the pressure transducer in described soft-medium side and adjacent inner coreGap is left between Si.
The present invention uses inside core filaments that "convex" shaped designs and is arranged on intermediate lands by the sensor of flat design, sensingDevice is formed between when installing with internal core filaments and fills soft-medium, this soft in gap, and gap square under the dieSoft-medium before chip stress deformation, can first be deformed avoiding the deformation of chip, thus improve bending resistance, obtain moreAdd accurate data；The ebonite of high intensity is filled, in order to sensor can be very in the sensor other end with the gap of internal core filamentsGood is fixed on above internal core filaments.
Further, described soft-medium is the flexible glue that shore hardness is less than 50A, and described hard medium is instant drying adhesive, describedPressure transducer be fixed on described supporting surface by described instant drying adhesive.
Described gap is 0.02～0.2mm at guidewire shaft width upwards.
The diameter dimension of the inside core filaments being positioned at described far-end pipe shaft is proximally gradually increased from far-end such that it is able to improve pressurePower seal wire passes through the ability of pathological changes.
Described far-end is welded in described inside core filaments around spring, and tapers off to a point semicircle head in distalmost end.
Further, described wire is at least one, and described conducting ring is consistent with described number of conductors.
Described wire includes multiply, and described dead ring is many groups be fixedly connected with conducting ring, and is often organizing dead ringBe also coaxially arranged with the interior dead ring being connected with corresponding conducting ring for isolating stranded conductor to be allowed in conducting ring.
Having hole on each described conducting ring, the wire of corresponding position is by being infused in the solder in described hole or sizing materialFix with described conducting ring and be connected.Use the design of one or more conducting rings, in order to be connected with outside line, will pressureForce signal passes to device end.The region that wire is connected with conducting ring is provided with interior dead ring to prevent from being formed between wire short circuit.
Described near-end outer tube is that outer surface scribbles low friction coefficient materials and forms lubricious metal tube, to reduce propelling movement processFrictional resistance suffered by.
The sensing chip that described pressure transducer includes cuboid-type sensing matrix, is arranged on described sensing matrix, describedOffering opening on developing ring, described sensing chip is corresponding with described aperture position, does it reducing other factorsDisturb, thus affect the precision of measurement.
Owing to technique scheme is used, the present invention compared with prior art has the advantage that the present invention measures seal wire can be realTime measure the measurement seal wire of Ink vessel transfusing blood pressure, it is provided that well propelling movement property and while turning round control power, owing to installing sensor portionThe seal wire divided uses "convex" shaped design to make sensor resistance to deformation bending resistance obtain bigger raising, it is ensured that measurement data is moreAccurately.
Accompanying drawing explanation
Fig. 1 is blood pressure pressure measxurement seal wire integral installation figure of the present invention；
Fig. 2 is the distal tube body structure schematic diagram that the present invention measures seal wire；
Fig. 3 is sensor and the core filaments assembling schematic diagram that the present invention measures seal wire；
It is seal wire with sensor assembled portion core filaments structural representation that Fig. 4 is that the present invention measures；
Fig. 5 is the proximal tube body structure schematic diagram that the present invention measures seal wire；
Fig. 6 is the linkage section part-structure schematic diagram that the present invention measures seal wire；
Fig. 7 is wire of the present invention and conducting ring installation diagram；
Wherein: 1, far-end pipe shaft；2, near-end pipe shaft；3, linkage section part；4, far-end is around spring；5, internal core filaments；51、Supporting surface；52, buffering suface；53, soft-medium；54, hard medium；55, gap；6, developing ring；61, opening；7, pressureForce transducer；71, sensing matrix；72, sensing chip；8, wire；9, far-end outer tube；10, near-end outer tube；11, exhaustedEdge ring；12, interior dead ring；13, conducting ring；15, leg；18, solder or sizing material.
Detailed description of the invention
Below in conjunction with accompanying drawing, the preferred embodiment of the present invention is described further:
" near-end ", " far-end " mentioned in the present invention refers to measure the distance of seal wire in use distance people, near holdingPasserby direction is near-end, otherwise is far-end.In the accompanying drawings, described far-end is with the left side of seal wire shown in Fig. 1 for defining, closelyHold with the right side of seal wire shown in Fig. 1 for defining.
As it is shown in figure 1, pressure measxurement seal wire of the present invention is mainly by far-end pipe shaft 1, near-end pipe shaft 2 and linkage section 3 three partComposition, three parts are coaxially disposed, and the external diameter of whole pressure measxurement seal wire is not more than 0.36mm.
The most as shown in Figures 2 to 4, far-end pipe shaft 1 by far-end around spring 4, internal core filaments 5, developing ring 6, pressure sensingDevice 7, wire 8 and far-end outer tube 9 are assembled.Wherein, far-end is set in internal core filaments 5 around spring 4, and by ironingThe modes such as weldering, Laser Welding, micro arc plasma welding form a smooth cup head in distalmost end, and this cup head can reduce leadsBlood vessel is caused damage by silk advance process.The described weldering use scolding tin that irons is unleaded tin silk or lead-free silver copper and tin silk.Far-end can around spring 4To use the material such as rustless steel or platinumiridio to make.In the present invention, far-end is 0.02-0.15mm around the string diameter of spring 4, outwardFootpath is less than 0.36mm.
Internal core filaments 5 is through the inside of whole seal wire pipe shaft, rustless steel that its material can select to commonly use, Nitinol orOther material being suitable for of person.The inside core filaments 5 being positioned in far-end pipe shaft 1 can be divided into again and is arranged at far-end front end in spring 4 and leadsCore filaments, the middle-end core filaments being arranged in developing ring 6 and the rear end core filaments being arranged in far-end outer tube 9.
Wherein, the front end core filament diameter being positioned in spring 4 is held wherein from distalmost end and is gradually increased, the most tapered transition, and it isBig end is directly about 0.20-0.30mm, and smallest end diameter is about 0.03-0.15mm, and such design can improve Pressure wire and wearThe more ability of pathological changes.
Being positioned at the middle-end core filaments 5 of developing ring 6 in " convex " font, describe for convenience, we are being positioned at this guide wire portion " convex "The uppermost plane definition of font is supporting surface 51, is positioned at supporting surface 51 both sides and is less than the plane definition of supporting surface 51 for bufferingFace 52, referring specifically to Fig. 4.Described pressure transducer 7 bottom surface is the plane paralleled with supporting surface 51 and load is located at supporting surfaceOn 51, so, between pressure transducer 7 lower surface and middle-end core filaments, it is formed with space, the left and right sides, in the present embodiment,It is filled with soft-medium 53 in the space in left side, between rightward space and pressure transducer 7 and supporting surface 51, is filled with hard JieMatter 54, described soft-medium 53 is less than flexible glue or other soft-medium of 50A for shore hardness, such as Loctite 595；This lowThe flexible glue of hardness or other soft-medium can first be deformed avoiding the deformation of chip before chip stress deformation, thus improve anti-Curved ability, obtains more accurate data；Described hard medium 54 is the ebonite of high intensity, such as Loctite 4981, in order to passSensor 7 can be good at being fixed on above internal core filaments 5.
In the present invention, between pressure transducer 7 and the adjacent inside core filaments 5 of described soft-medium 53 side, leave gap55, in the present embodiment, described gap 55 is positioned at left side, sees Fig. 3.This gap 55 at guidewire shaft width is upwards0.02～0.2mm.By forming gap 55 between sensor chip 7 and core filaments 5, and due to the sky below this gap 55In be filled with soft-medium, the soft-medium of this soft can first be deformed avoiding the change of chip before chip stress deformationShape, thus improve bending resistance, obtain more accurate data.
Described pressure transducer 7 by cuboid-type sensing matrix 71, be arranged on sensing matrix 71 on sensing chip 72 form,And have at least one leg 15 on sensing matrix 71.Connect on each leg and have wire 8, wire 8 and pressure transducer 7Leg 15 by ironing weldering, the modes such as gluing, thermocompression bonding of conducting electricity are assembled and are formed conductive path together.Described ironing welds use scolding tinFor unleaded tin silk or lead-free silver copper and tin silk.Described conducting resinl can use the glue that electrical conductivity is high, such as Loctite 3888.Described leadThe line footpath of line 8 is about 0.02-0.10mm.Described pressure transducer 7 is to be etched the EMES works such as technique at polysilicon surfaceSkill is fabricated by.
As it is shown on figure 3, pressure transducer 7 is linked together with wire 8 by leg 15, then by glue and inner coreThe convex platform of silk 5 is mutually bonded together.Internal core filaments 5 is bonded together also by instant drying adhesive with developing ring 6, such as Loctite4981；Offering opening 61 on developing ring 6, this opening should be relative with sensor chip 72, to reduce other factors to itInterference, thus affect the precision of measurement.Developing ring 6 material can use the material that development effect is good, such as platinumiridio, HuangThe materials such as gold, tungsten.And hydrophilic lubricant coating can be coated on remote area surface, to reduce frictional resistance.
Described far-end outer tube 9 can be use the material such as rustless steel or platinumiridio around spring, it would however also be possible to employ by polyurethane,The pipe that the engineering materials such as polymerization nylon, polyester, Formvar and polyimides manufacture.Its two ends respectively with developmentRing 6 and near-end outer tube 10 are fixedly connected by gluing.This gluing glue uses the glue that adhesion strength is higher, asLoctite 4981.The external diameter of far-end outer tube 9 is less than 0.36mm, and monolateral wall thickness is about 0.01-0.15mm.
Near-end pipe shaft 2 is made up of, as shown in Figure 5 internal core filaments 5, wire 8 and near-end outer tube 10.The table of near-end outer tube 10Topcoating has the low friction coefficient materials such as politef or Parylene, and its internal diameter is about 0.18-0.30mm, and monolateral thickness is aboutFor 0.025-0.10mm.The material of pipe shaft uses rustless steel, Nitinol or other metal material.Described near-end outer tube 10Proximally and distally using instant drying adhesive to bond with far-end outer tube 9 and linkage section part 3 at it respectively, described instant drying adhesive should useThe glue that adhesion strength is higher, such as Loctite 4981.Core filaments 5 and wire 8 at proximally-located outer tube 9 two ends are also inserted wink and are doneGlue carries out bonding assembling.Owing to near-end outer tube 10 outer surface scribbles lubricious, can effectively reduce during propelling movement sufferedFrictional resistance.
Shown in Fig. 6 for linkage section part 3, its conducting ring 13 being fixedly and coaxially connected by dead ring 11 and dead ring 11,And be arranged on and be located in dead ring 11 and form with the inside core filaments 5 in conducting ring 13 and wire 8.In the present embodiment, in pressureConnecting on force transducer 7 and have three strands of wires 8, per share wire needs to be conducted with a conducting ring 13, therefore forms three groups of dead rings11 and conducting ring 13 right.Meanwhile, in order to prevent short circuit, in being additionally provided with in the dead ring 11 of each group with conducting ring 13Dead ring 12.The most described external insulation ring 11 has three sections of compositions, and it covers in the outside of interior dead ring 12, and two ends are respectively with interiorDead ring 12 and near-end outer tube 10 or conducting ring 13 are fixed together by the glue of high intensity, such as Loctite 4981.Outer exhaustedThe interior warp of edge ring 11 is about 0.25-0.30mm, and monolateral thickness is about 0.025-0.05mm.Interior dead ring 12 has four sections of compositions,Wherein one meeting of the compenzine of wire 8 pass between dead ring 12 in adjacent two, and be connected shape with corresponding conducting ring 13Become conductive path.Interior dead ring 12 covers on internal core filaments 5 and the surface of wire 8, and its two ends are respectively with the glue of high intensityIt is fixed together, such as Loctite 4981 with internal core filaments 5 and wire 8.The interior warp of interior dead ring 12 is about 0.20-0.30mm,Monolateral thickness is about 0.025-0.05mm.Conducting ring 13 has three sections of compositions, and it covers outside interior dead ring 12 and wire 8Face, and with the wire 8 stretched out wherein one by iron weldering or glued joint assemble, formed conductive path.Described conducting ring 13Two ends be fixed together by the glue of high intensity with interior dead ring 12 and external insulation ring 11 respectively.Described conducting ring 13 isMiddle part or the metal tube of end band perforate, perforate length is about 0.1-4mm, and width is about 0.1-0.36mm.Described conducting ring 13External diameter less than 0.36mm, monolateral thickness is about 0.02-0.10mm.As it is shown in fig. 7, the conducting ring 13 in above-mentioned passes throughSolder or the sizing material 18 of injection are linked together with wire 8 by the mode ironing weldering or viscose glue by the perforate above conducting ring 13.The material of conducting ring 13 can be that conductive capability is higher, and has the metal material of certain degree of hardness, as rustless steel, gold, silver,The materials such as platinumiridio.It is higher that dead ring 11 and 12 can be selected for insulating coefficient, and the resistant to elevated temperatures engineering plastics of energy, such as polyamidesImines, polyimide, polyether-ether-ketone etc..The heart yearn material of described wire 8 can be the metal material that the electric conductivity such as copper, silver is strongOr alloy material, and outside heart yearn be coated with one layer of insulant, this insulant can be polyurethane, polymerization nylon, polyester,The engineering material such as Formvar and polyimides.
The structure that the above-mentioned vascular pressure being preferable to carry out the present invention measures seal wire has been described in detail, it will be seen thatIn the present invention, internal core filaments 5 is through the inside of whole seal wire pipe shaft, in order to reach preferable flexing resistance and provide enough strongDegree, is designed to "convex" shaped by the inside core filaments with pressure transducer joining part, and in sensor chip and internal core filaments 5Formed between during installation and gap, and gap square under the die are filled soft-medium, so ensure that in chip stressFirst it is deformed avoiding the deformation of chip before deformation, thus improves bending resistance, obtain more accurate data.
Above-described embodiment, only for technology design and the feature of the explanation present invention, its object is to allow the person skilled in the art canUnderstand present disclosure and implement according to this, can not limit the scope of the invention with this.All according to spirit of the inventionThe equivalence change made or modification, all should contain within protection scope of the present invention.