技术领域technical field
本发明涉及医疗设备技术领域，尤其涉及一种多模态阴道镜系统及获取多模态图像的方法。The invention relates to the technical field of medical equipment, in particular to a multimodal colposcope system and a method for acquiring multimodal images.
背景技术Background technique
全球范围内，宫颈癌发病率在女性恶性肿瘤中居第二位，仅次于乳腺癌。而在发展中国家，由于宫颈筛查工作的不完善，宫颈癌发生率是发达国家的6倍，死亡率居女性癌症之首。传统的宫颈检查方法主要有巴氏涂片法和阴道镜检查。Globally, the incidence of cervical cancer ranks second among female malignancies, second only to breast cancer. In developing countries, due to imperfect cervical screening, the incidence of cervical cancer is six times that of developed countries, and the death rate ranks first among female cancers. Traditional cervical screening methods mainly include Pap smear and colposcopy.
但是，前者误诊率高、受检者痛苦、检查周期长，后者可以实现宫颈组织的RGB彩色成像，但只能从组织表面的颜色和形态上直观地进行判断，无法区分良性的上皮组织变化和恶性肿瘤。However, the former has a high rate of misdiagnosis, pain for the examinee, and long inspection cycle, while the latter can realize RGB color imaging of cervical tissue, but it can only be judged intuitively from the color and shape of the tissue surface, and cannot distinguish benign epithelial tissue changes. and malignant tumors.
发明内容Contents of the invention
本发明的目的是提供一种多模态阴道镜系统及获取多模态图像的方法，可以将多种医学影像技术有机地融合在一起，实现对同一病灶区域不同方面(结构、功能、分子)信息的获取，能够极大地帮助医生掌握全面的病理信息，提高诊断的正确率。The purpose of the present invention is to provide a multi-modal colposcopy system and a method for acquiring multi-modal images, which can organically integrate various medical imaging technologies to realize different aspects (structure, function, molecule) of the same lesion area. The acquisition of information can greatly help doctors master comprehensive pathological information and improve the accuracy of diagnosis.
本发明的目的是通过以下技术方案实现的：The purpose of the present invention is achieved through the following technical solutions:
一种多模态阴道镜系统，该系统包括：影像模块、光源模块、控制模块以及结构模块；A multi-mode colposcope system, the system includes: an image module, a light source module, a control module and a structure module;
所述影像模块包括：感光器件、镜头、滤光片与计算机；所述感光器件与计算机相连，所述镜头固定安装在感光器件上，所述滤光片放置在镜头前方；The image module includes: a photosensitive device, a lens, a filter and a computer; the photosensitive device is connected to the computer, the lens is fixedly installed on the photosensitive device, and the photofilter is placed in front of the lens;
所述光源模块放置在滤光片前方，其包括：若干个不同波长的贴片式超亮LED灯珠，均匀地分布在环形的照射面上，分别作为荧光激发光源、RGB彩色成像光源和多光谱成像光源；The light source module is placed in front of the filter, which includes: several patch-type super bright LED lamp beads of different wavelengths, which are evenly distributed on the ring-shaped irradiation surface, and are respectively used as a fluorescent excitation light source, an RGB color imaging light source and a multi-color imaging light source. Spectral imaging light source;
控制模块一端与所述光源模块相连为光源模块提供电源，另一端与计算机相连，根据计算机发送的指令对光源模块进行控制；One end of the control module is connected to the light source module to provide power for the light source module, and the other end is connected to the computer to control the light source module according to the instructions sent by the computer;
结构模块包括：支撑板、设置在该支撑板下方的支架，以及设置在支撑板上的滤光片切换装置；其中，所述滤光片放置在滤光片切换装置上，感光器件与光源模块均放置在所述支撑板上。The structural module includes: a support plate, a bracket arranged under the support plate, and an optical filter switching device arranged on the support plate; wherein, the optical filter is placed on the optical filter switching device, and the photosensitive device and the light source module are placed on the support plate.
进一步的，所述光源模块包括：Further, the light source module includes:
365nm、475nm、530nm、545nmm、560nm、575nm、590nm与635nm的贴片式超亮LED灯珠各八颗；按照照射面中心线的划分，各个象限间的LED灯珠排布一致；在每个象限内，每种波长的灯珠数量各有两颗，相互之间为并联关系；365nm, 475nm, 530nm, 545nmm, 560nm, 575nm, 590nm and 635nm SMD super bright LED lamp beads each eight; according to the division of the center line of the irradiation surface, the arrangement of LED lamp beads in each quadrant is consistent; In the quadrant, there are two lamp beads for each wavelength, and they are in parallel relationship with each other;
其中，365nm的贴片式超亮LED灯珠作为荧光激发光源，635nm、545nm与475nm的贴片式超亮LED灯珠作为RGB彩色成像光源，530nm、545nm、560nm、575nm与590nm的贴片式超亮LED灯珠作为多光谱成像光源。Among them, 365nm SMD super bright LED lamp beads are used as fluorescent excitation light source, 635nm, 545nm and 475nm SMD super bright LED lamp beads are used as RGB color imaging light source, 530nm, 545nm, 560nm, 575nm and 590nm SMD Ultra-bright LED lamp beads are used as a multi-spectral imaging light source.
进一步的，所述控制模块包括：多个独立的用于控制LED灯珠开关和亮度的通道。Further, the control module includes: a plurality of independent channels for controlling the switch and brightness of the LED lamp bead.
一种利用前述系统来获取多模态图像的方法，该方法包括：A method of acquiring multimodal images using the foregoing system, the method comprising:
调整感光器件与镜头，使待观察的宫颈组织符合视场大小；Adjust the photosensitive device and the lens so that the cervical tissue to be observed conforms to the field of view;
再利用计算机控制控制模块来调节光源模块，依次进行多光谱成像、自发荧光成像与RGB彩色成像，从而获得多模态图像；Then use the computer to control the control module to adjust the light source module, and then perform multi-spectral imaging, autofluorescence imaging and RGB color imaging in sequence to obtain multi-modal images;
其中，在进行多光谱成像时，利用标准反射块放置在观察的宫颈组织表面进行预曝光后，取下该标准反射块，再对观察的宫颈组织进行多光谱成像；且进行多光谱成像时通过滤光片切换装置调整滤光片的位置，使滤光片不遮挡成像光路；Wherein, when performing multispectral imaging, a standard reflection block is placed on the surface of the observed cervical tissue for pre-exposure, the standard reflection block is removed, and then multispectral imaging is performed on the observed cervical tissue; The filter switching device adjusts the position of the filter so that the filter does not block the imaging optical path;
在进行自发荧光成像时，通过滤光片切换装置调整滤光片的位置，使滤光片遮挡住成像光路；When performing autofluorescence imaging, adjust the position of the filter through the filter switching device, so that the filter blocks the imaging optical path;
在进行RGB彩色成像时，通过滤光片切换装置调整滤光片的位置，使滤光片不遮挡成像光路。When performing RGB color imaging, the position of the optical filter is adjusted by the optical filter switching device so that the optical filter does not block the imaging optical path.
进一步的，所述标准反射块是一个安置在环状外壳中的聚四氟乙烯白板，经过表面抛光处理，并在粘附一个带“+”形标记的纸片上作为对焦的标记物。Further, the standard reflection block is a polytetrafluoroethylene white board placed in a ring-shaped casing, the surface is polished, and a paper with a "+" mark is attached as a focus mark.
进一步的，所述光源模块包括：365nm、475nm、530nm、545nmm、560nm、575nm、590nm与635nm的贴片式超亮LED灯珠各八颗；按照照射面中心线的划分，各个象限间的LED灯珠排布一致；在每个象限内，每种波长的灯珠数量各有两颗，相互之间为并联关系；Further, the light source module includes: 365nm, 475nm, 530nm, 545nm, 560nm, 575nm, 590nm and 635nm each eight SMD super bright LED beads; The lamp beads are arranged in the same way; in each quadrant, there are two lamp beads of each wavelength, and they are in parallel relationship with each other;
其中，365nm的贴片式超亮LED灯珠作为荧光激发光源，635nm、545nm与475nm的贴片式超亮LED灯珠作为RGB彩色成像光源，530nm、545nm、560nm、575nm与590nm的贴片式超亮LED灯珠作为多光谱成像光源。Among them, 365nm SMD super bright LED lamp beads are used as fluorescent excitation light source, 635nm, 545nm and 475nm SMD super bright LED lamp beads are used as RGB color imaging light source, 530nm, 545nm, 560nm, 575nm and 590nm SMD Ultra-bright LED lamp beads are used as a multi-spectral imaging light source.
进一步的，所述控制模块包括：多个独立的用于控制LED灯珠开关和亮度的通道。Further, the control module includes: a plurality of independent channels for controlling the switch and brightness of the LED lamp bead.
由上述本发明提供的技术方案可以看出，通过特殊排布设计和波长选用的超亮LED光源及成像模块，独立地控制光源各个通道的开断和强度，有机地把几种不同的医学成像模态融合起来：多光谱成像可以有效地对物质组成进行分类，宫颈自发荧光成像可以根据荧光强度区分正常和病变组织，常规的RGB彩色成像可以从形态、颜色等方面指导医生判断病灶的发展程度，从而为医生提供更为全面、准确和定量的诊断依据。It can be seen from the above-mentioned technical solution provided by the present invention that through the super-bright LED light source and imaging module with special arrangement design and wavelength selection, the on-off and intensity of each channel of the light source can be independently controlled, and several different medical imaging methods can be organically controlled. Modal fusion: multispectral imaging can effectively classify material composition, cervical autofluorescence imaging can distinguish normal and diseased tissues according to fluorescence intensity, and conventional RGB color imaging can guide doctors to judge the development degree of lesions from aspects such as shape and color , so as to provide doctors with a more comprehensive, accurate and quantitative basis for diagnosis.
附图说明Description of drawings
为了更清楚地说明本发明实施例的技术方案，下面将对实施例描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域的普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他附图。In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following will briefly introduce the accompanying drawings that need to be used in the description of the embodiments. Obviously, the accompanying drawings in the following description are only some embodiments of the present invention. For Those of ordinary skill in the art can also obtain other drawings based on these drawings on the premise of not paying creative work.
图1为本发明实施例一提供的一种多模态阴道镜系统的示意图；FIG. 1 is a schematic diagram of a multimodal colposcopy system provided by Embodiment 1 of the present invention;
图2为本发明实施例一提供的光源模块的示意图；FIG. 2 is a schematic diagram of a light source module provided by Embodiment 1 of the present invention;
图3为本发明实施例二提供的多模态阴道镜系统的操作步骤流程图。Fig. 3 is a flowchart of the operation steps of the multimodal colposcopy system provided by the second embodiment of the present invention.
具体实施方式Detailed ways
下面结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明的保护范围。The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.
成分分布图，为分析、检测提供更为精准的信息。多光谱成像技术主要是以物质对不同波长光的吸收存在差异为原理，利用预先筛选出的一组特定波长，采集待检测组织表面的反射强度信息，并通过特定的图像分类算法，对样品的组成成分进行分类。Composition distribution map provides more accurate information for analysis and detection. Multispectral imaging technology is mainly based on the principle that substances absorb light of different wavelengths differently. Using a set of specific wavelengths that are pre-screened, the reflection intensity information on the surface of the tissue to be detected is collected, and through a specific image classification algorithm, the image of the sample is analyzed. Components are classified.
人体组织内含有多种自发性的荧光物质，在特定激发光的照射下会发出特定的荧光。宫颈自发荧光诊断技术是利用宫颈正常组织和癌变组织在固有荧光特性上的差异，在特定波长激发光的照射下，在特定波长处采集荧光图像，从荧光强度上对正常和癌变组织进行区分。There are a variety of spontaneous fluorescent substances in human tissue, which will emit specific fluorescence under the irradiation of specific excitation light. Cervical autofluorescence diagnostic technology uses the difference in intrinsic fluorescence characteristics between normal cervical tissue and cancerous tissue, under the irradiation of specific wavelength excitation light, collects fluorescence images at specific wavelengths, and distinguishes normal and cancerous tissue from the fluorescence intensity.
多模态医学成像技术是将两种或多种医学影像技术有机地融合在一起，实现对同一病灶区域不同方面(结构、功能、分子)信息的获取，能够极大地帮助医生掌握全面的病理信息，提高诊断的正确率。因此，如果能够把现有的宫颈组织RGB彩色成像、多光谱成像和自发荧光成像结合起来，将为宫颈癌的初步筛查提供新的视角和手段。Multimodal medical imaging technology is an organic fusion of two or more medical imaging technologies to obtain different aspects (structure, function, molecular) information of the same lesion area, which can greatly help doctors master comprehensive pathological information , improve the accuracy of diagnosis. Therefore, if the existing cervical tissue RGB color imaging, multispectral imaging and autofluorescence imaging can be combined, it will provide a new perspective and means for the initial screening of cervical cancer.
实施例一Embodiment one
图1为本发明实施例提供的一种多模态阴道镜系统的示意图，如图1所示，该系统主要包括：影像模块、光源模块、控制模块以及结构模块；Fig. 1 is a schematic diagram of a multimodal colposcopy system provided by an embodiment of the present invention. As shown in Fig. 1, the system mainly includes: an image module, a light source module, a control module and a structural module;
所述影像模块包括：感光器件6、镜头5、滤光片4与计算机8；所述感光器件6与计算机8相连，所述镜头5固定安装在感光器件6上，所述滤光片4放置在镜头5前方。The image module includes: a photosensitive device 6, a lens 5, a filter 4 and a computer 8; the photosensitive device 6 is connected to the computer 8, the lens 5 is fixedly installed on the photosensitive device 6, and the optical filter 4 In front of lens 5.
示例性的，感光器件可以为CCD工业相机，可以采集12位的黑白单色图像，其CCD光谱响应曲线在470-600nm波段的效率>80％，对多光谱影像和荧光影像由较好的收集效率。CCD工业相机通过1394A火线与计算机8上的数据采集卡相连接，实现图像采集和数据传输。镜头5通过C卡口安装在工业相机6上，可以手动调节光圈大小和对焦，并合适的工作距离下采集到符合视场大小的宫颈组织图像，相比于变焦镜头，定焦镜头具有更高的成像素质。滤光片4可以为420-480nm带通滤光片，直径25.4mm，用于收集420-480nm波段的组织荧光影像，在365nm激发光下，正常组织和非正常组织的荧光光谱在该波段有明显差异。Exemplarily, the photosensitive device can be a CCD industrial camera, which can collect 12-bit black-and-white monochrome images, and the efficiency of its CCD spectral response curve in the 470-600nm band is >80%, which is better for multi-spectral images and fluorescent images. efficiency. The CCD industrial camera is connected with the data acquisition card on the computer 8 through a 1394A fire wire to realize image acquisition and data transmission. The lens 5 is installed on the industrial camera 6 through the C bayonet. The aperture size and focus can be manually adjusted, and the cervical tissue image that meets the field of view can be collected at a suitable working distance. Compared with the zoom lens, the fixed-focus lens has a higher image quality. The filter 4 can be a 420-480nm band-pass filter with a diameter of 25.4mm, which is used to collect tissue fluorescence images in the 420-480nm band. Under 365nm excitation light, the fluorescence spectra of normal tissues and abnormal tissues have Significant differences.
所述光源模块3放置在滤光片4前方，其包括：若干个不同波长的贴片式超亮LED灯珠，均匀地分布在环形的照射面上，分别作为荧光激发光源、RGB彩色成像光源和多光谱成像光源；按照照射面中心线的划分，各个象限间的LED灯珠排布一致；在每个象限内，每种波长的灯珠数量相同，相互之间为并联关系。The light source module 3 is placed in front of the filter 4, which includes: several patch-type super bright LED lamp beads of different wavelengths, which are evenly distributed on the ring-shaped irradiation surface, and are respectively used as a fluorescent excitation light source and an RGB color imaging light source. And multi-spectral imaging light source; according to the division of the center line of the irradiation surface, the LED lamp beads in each quadrant are arranged in the same way; in each quadrant, the number of lamp beads of each wavelength is the same, and they are in parallel relationship with each other.
示例性的，如图2所示为光源模块的示意图。图2所示的光源模块中包括：365nm(9)、475nm(10)、530nm(12)、545nmm(13)、560nm(14)、575nm(15)、590nm(16)、635nm(11)的贴片式超亮LED灯珠各八颗，均匀地分布在环形的照射面上，分别作为荧光激发光源(365nm)、RGB彩色成像光源(635nm、545nm、475nm)和多光谱成像光源(530nm、545nm、560nm、575nm、590nm)；在每个象限内，每种波长的灯珠数量有各两颗。Exemplarily, FIG. 2 is a schematic diagram of a light source module. The light source module shown in Figure 2 includes: Eight SMD super bright LED lamp beads are evenly distributed on the ring-shaped irradiation surface, which are respectively used as fluorescence excitation light source (365nm), RGB color imaging light source (635nm, 545nm, 475nm) and multi-spectral imaging light source (530nm, 545nm, 560nm, 575nm, 590nm); in each quadrant, there are two lamp beads for each wavelength.
控制模块7一端与所述光源模块相连为光源模块提供电源，另一端与计算机相连，根据计算机发送的指令对光源模块进行控制。One end of the control module 7 is connected to the light source module to provide power for the light source module, and the other end is connected to the computer to control the light source module according to the instructions sent by the computer.
进一步的，控制模块7包括：多个独立的用于控制LED灯珠开关和亮度的通道。例如，具有八个通道，每个通道可以独立的控制开关和亮度，输出电压24V，可以自动检测负载最大电流。Further, the control module 7 includes: a plurality of independent channels for controlling the switch and brightness of the LED lamp bead. For example, there are eight channels, each channel can independently control the switch and brightness, the output voltage is 24V, and the maximum current of the load can be automatically detected.
结构模块包括：支撑板17、设置在该支撑板下方的支架1，以及设置在支撑板上的滤光片切换装置2；其中，所述滤光片4放置在滤光片切换装置2上，感光器件6与光源模块3均放置在所述支撑板上。支架1上，可以自由的调节和锁紧高度，左右方向和俯仰角。滤光片切换装置用于调整不同模态时的工作光路：当采集多光谱图像和RGB彩色图像时，调整滤光片4不挡住成像光路；当采集宫颈组织自发荧光时，调整滤光片4于镜头5前，挡住光路，并用螺丝拧紧固定，只收集420-480nm波段的荧光影像。The structural module includes: a support plate 17, a bracket 1 arranged below the support plate, and an optical filter switching device 2 arranged on the support plate; wherein, the optical filter 4 is placed on the optical filter switching device 2, Both the photosensitive device 6 and the light source module 3 are placed on the support plate. On the bracket 1, the height, left and right direction and pitch angle can be freely adjusted and locked. The optical filter switching device is used to adjust the working optical path in different modes: when collecting multispectral images and RGB color images, adjust the optical filter 4 not to block the imaging optical path; when collecting autofluorescence of cervical tissue, adjust the optical filter 4 In front of the lens 5, block the light path and tighten it with screws to collect only fluorescence images in the 420-480nm band.
本发明实施例通过特殊排布设计和波长选用的超亮LED光源及成像模块，独立地控制光源各个通道的开断和强度，有机地把几种不同的医学成像模态融合起来：多光谱成像可以有效地对物质组成进行分类，宫颈自发荧光成像可以根据荧光强度区分正常和病变组织，常规的RGB彩色成像可以从形态、颜色等方面指导医生判断病灶的发展程度，从而为医生提供更为全面、准确和定量的诊断依据。The embodiment of the present invention independently controls the on-off and intensity of each channel of the light source through the super-bright LED light source and imaging module with special arrangement design and wavelength selection, and organically integrates several different medical imaging modalities: multi-spectral imaging It can effectively classify the material composition. Cervical autofluorescence imaging can distinguish normal and diseased tissues according to the fluorescence intensity. Conventional RGB color imaging can guide doctors to judge the development degree of lesions from aspects such as shape and color, so as to provide doctors with more comprehensive information. , Accurate and quantitative diagnostic basis.
实施例二Embodiment two
本发明实施例提供一种获取多模态图像的方法，该方法是基于前述实施例提供的多模态阴道镜系统来实现，该方法主要包括：An embodiment of the present invention provides a method for acquiring multimodal images, which is implemented based on the multimodal colposcopy system provided in the foregoing embodiments, and the method mainly includes:
调整感光器件与镜头，使待观察的宫颈组织符合视场大小；Adjust the photosensitive device and the lens so that the cervical tissue to be observed conforms to the field of view;
再利用计算机控制控制模块来调节光源模块，依次进行多光谱成像、自发荧光成像与RGB彩色成像，从而获得多模态图像；Then use the computer to control the control module to adjust the light source module, and then perform multi-spectral imaging, autofluorescence imaging and RGB color imaging in sequence to obtain multi-modal images;
其中，在进行多光谱成像时，利用标准反射块放置在观察的宫颈组织表面进行预曝光后，取下该标准反射块，再对观察的宫颈组织进行多光谱成像；且进行多光谱成像时通过滤光片切换装置调整滤光片的位置，使滤光片不遮挡成像光路；Wherein, when performing multispectral imaging, a standard reflection block is placed on the surface of the observed cervical tissue for pre-exposure, the standard reflection block is removed, and then multispectral imaging is performed on the observed cervical tissue; The filter switching device adjusts the position of the filter so that the filter does not block the imaging optical path;
在进行自发荧光成像时，通过滤光片切换装置调整滤光片的位置，使滤光片遮挡住成像光路；When performing autofluorescence imaging, adjust the position of the filter through the filter switching device, so that the filter blocks the imaging optical path;
在进行RGB彩色成像时，通过滤光片切换装置调整滤光片的位置，使滤光片不遮挡成像光路。When performing RGB color imaging, the position of the optical filter is adjusted by the optical filter switching device so that the optical filter does not block the imaging optical path.
所述标准反射块是一个安置在环状外壳中的聚四氟乙烯白板，经过表面抛光处理，并在粘附一个带“+”形标记的纸片上作为对焦的标记物。The standard reflection block is a polytetrafluoroethylene white board placed in a ring-shaped casing, the surface is polished, and a paper with a "+" mark is attached as a focus mark.
所述光源模块包括：365nm、475nm、530nm、545nmm、560nm、575nm、590nm与635nm的贴片式超亮LED灯珠各八颗；按照照射面中心线的划分，各个象限间的LED灯珠排布一致；在每个象限内，每种波长的灯珠数量各有两颗，相互之间为并联关系；The light source module includes: 365nm, 475nm, 530nm, 545nm, 560nm, 575nm, 590nm and 635nm each eight SMD super bright LED lamp beads; The distribution is consistent; in each quadrant, there are two lamp beads of each wavelength, and they are in parallel relationship with each other;
其中，365nm的贴片式超亮LED灯珠作为荧光激发光源，635nm、545nm与475nm的贴片式超亮LED灯珠作为RGB彩色成像光源，530nm、545nm、560nm、575nm与590nm的贴片式超亮LED灯珠作为多光谱成像光源。Among them, 365nm SMD super bright LED lamp beads are used as fluorescent excitation light source, 635nm, 545nm and 475nm SMD super bright LED lamp beads are used as RGB color imaging light source, 530nm, 545nm, 560nm, 575nm and 590nm SMD Ultra-bright LED lamp beads are used as a multi-spectral imaging light source.
所述控制模块包括：多个独立的用于控制LED灯珠开关和亮度的通道。The control module includes: a plurality of independent channels for controlling the switch and brightness of the LED lamp bead.
为了便于理解，下面结合附图3对该方法的步骤做详细的说明。For ease of understanding, the steps of the method will be described in detail below in conjunction with FIG. 3 .
在多模态影像采集过程中，需要事先准备用于反射率校正的标准反射块。标准反射块是一个安置在环状外壳中的聚四氟乙烯(特氟龙)白板，经过表面抛光处理，并在粘附一个带“+”形标记的纸片作为相机对焦的标记物。因为聚四氟乙烯在200-1000nm波段有较为平均的反射率，可用来对多光谱成像中各个波长进行光源强度差异的校正。在使用之前，需要进行消毒，并且不得重复使用。In the process of multimodal image acquisition, it is necessary to prepare standard reflection blocks for reflectivity correction in advance. The standard reflection block is a polytetrafluoroethylene (Teflon) white board placed in a ring-shaped shell, which has been polished on the surface, and a piece of paper with a "+" mark is attached as a marker for camera focus. Because PTFE has a relatively average reflectance in the 200-1000nm band, it can be used to correct the difference in light source intensity for each wavelength in multispectral imaging. Before use, it needs to be sterilized and must not be reused.
其步骤如图3所示，包括：The steps are shown in Figure 3, including:
1)待检查者就位，打开成像仪电源，打开成像仪操作界面。1) Wait for the examiner to be in place, turn on the power of the imager, and open the operation interface of the imager.
2)在软件上登记病人姓名和保存路径。2) Register the patient's name and save path on the software.
3)调整成像仪位置，使待观察的宫颈组织符合视场大小。3) Adjust the position of the imager so that the cervical tissue to be observed conforms to the size of the field of view.
4)多光谱成像。4) Multispectral imaging.
a)用镊子将消过毒的标准反射块放置在组织表面，镜头准确对焦；a) Place the sterilized standard reflection block on the surface of the tissue with tweezers, and focus the lens accurately;
b)预曝光：依次点亮530nm，545nm，560nm，575nm，590nm波长LED灯珠，进行一次自动曝光调节，保证采集数据曝光参数合适，并记录每个波长下的曝光参数；b) Pre-exposure: turn on the 530nm, 545nm, 560nm, 575nm, 590nm wavelength LED beads in sequence, perform an automatic exposure adjustment to ensure that the exposure parameters of the collected data are appropriate, and record the exposure parameters at each wavelength;
c)带标准反射块采集：再次依次点亮上述灯珠，各个灯珠点亮的同时，触发相机，采集当前波长下的图像；c) Acquisition with standard reflector block: turn on the above lamp beads in sequence again, trigger the camera at the same time as each lamp bead is lit, and collect images at the current wavelength;
d)取下标准反射块采集：重复上述采集过程，多光谱成像结束；d) Take off the standard reflection block for collection: repeat the above collection process, and the multispectral imaging ends;
e)经过特征提取分类算法，得到并保存多光谱分类图。e) Obtain and save the multi-spectral classification map through the feature extraction classification algorithm.
5)宫颈自发荧光成像。5) Cervical autofluorescence imaging.
a)点亮365nm荧光激发光；a) light up the 365nm fluorescent excitation light;
b)手动调整荧光滤光片，遮挡住光路并锁紧；b) Manually adjust the fluorescence filter to block the light path and lock it;
c)调整合适曝光参数，获取并保存荧光图像；c) adjusting appropriate exposure parameters, acquiring and saving the fluorescent image;
d)荧光滤光片复位，荧光成像结束。d) The fluorescence filter is reset, and the fluorescence imaging ends.
6)RGB彩色成像。6) RGB color imaging.
a)红色(635nm)、绿色(545nm)、蓝色(475nm)LED灯珠依次点亮；a) Red (635nm), green (545nm), and blue (475nm) LED beads are lit in sequence;
b)各个灯珠点亮同时，触发相机，采集当前波长下的图像；b) At the same time as each lamp bead is lit, the camera is triggered to collect images at the current wavelength;
c)把三个波长下的图像合成RGB彩色图像；c) synthesizing the images under the three wavelengths into an RGB color image;
d)保存RGB彩色图像，RGB彩色成像结束。d) Save the RGB color image, and the RGB color imaging ends.
7)获得多模态的图像数据。7) Obtain multimodal image data.
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明披露的技术范围内，可轻易想到的变化或替换，都应涵盖在本发明的保护范围之内。因此，本发明的保护范围应该以权利要求书的保护范围为准。The above is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person familiar with the technical field can easily conceive of changes or changes within the technical scope disclosed in the present invention. Replacement should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be determined by the protection scope of the claims.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410821090.0ACN104434013A (en) | 2014-12-24 | 2014-12-24 | Multimodal colposcope system and method for acquiring multimodal images |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410821090.0ACN104434013A (en) | 2014-12-24 | 2014-12-24 | Multimodal colposcope system and method for acquiring multimodal images |
| Publication Number | Publication Date |
|---|---|
| CN104434013Atrue CN104434013A (en) | 2015-03-25 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410821090.0APendingCN104434013A (en) | 2014-12-24 | 2014-12-24 | Multimodal colposcope system and method for acquiring multimodal images |
| Country | Link |
|---|---|
| CN (1) | CN104434013A (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105476598A (en)* | 2016-01-12 | 2016-04-13 | 深圳市理邦精密仪器股份有限公司 | Adjusting method and device for working distance of colposcope |
| CN109656014A (en)* | 2019-01-31 | 2019-04-19 | 北京超维景生物科技有限公司 | Multichannel phosphor collection device and three dimensional non-linear laser scanning cavity endoscope |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090137908A1 (en)* | 2007-11-26 | 2009-05-28 | Patwardhan Sachin V | Multi-spectral tissue imaging |
| CN101744611A (en)* | 2008-12-10 | 2010-06-23 | 韩国电气研究院 | Apparatus for photodynamic therapy and photo detection |
| CN102893137A (en)* | 2010-03-17 | 2013-01-23 | 曾海山 | Fast multispectral imaging method and device and application for cancer detection and localization |
| CN103230252A (en)* | 2013-04-12 | 2013-08-07 | 中国科学院上海光学精密机械研究所 | Multi-spectral imaging endoscopic detection system and method |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090137908A1 (en)* | 2007-11-26 | 2009-05-28 | Patwardhan Sachin V | Multi-spectral tissue imaging |
| CN101744611A (en)* | 2008-12-10 | 2010-06-23 | 韩国电气研究院 | Apparatus for photodynamic therapy and photo detection |
| CN102893137A (en)* | 2010-03-17 | 2013-01-23 | 曾海山 | Fast multispectral imaging method and device and application for cancer detection and localization |
| CN103230252A (en)* | 2013-04-12 | 2013-08-07 | 中国科学院上海光学精密机械研究所 | Multi-spectral imaging endoscopic detection system and method |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105476598A (en)* | 2016-01-12 | 2016-04-13 | 深圳市理邦精密仪器股份有限公司 | Adjusting method and device for working distance of colposcope |
| CN105476598B (en)* | 2016-01-12 | 2017-05-03 | 深圳市理邦精密仪器股份有限公司 | Adjusting method and device for working distance of colposcope |
| CN109656014A (en)* | 2019-01-31 | 2019-04-19 | 北京超维景生物科技有限公司 | Multichannel phosphor collection device and three dimensional non-linear laser scanning cavity endoscope |
| CN109656014B (en)* | 2019-01-31 | 2024-03-19 | 北京超维景生物科技有限公司 | Multipath fluorescence collection device and three-dimensional nonlinear laser scanning cavity endoscope |
| Publication | Publication Date | Title |
|---|---|---|
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|---|---|---|---|
| C06 | Publication | ||
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| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication | Application publication date:20150325 |