Background technology
Radio frequency ablation catheter is a kind of conventional electrophysiologicalcatheter catheter, is frequently used to treat arrhythmia, heart failure, battle array at presentThe diseases such as the property sent out atrial fibrillation, for example, be used against different diseases execution renal artery denervation ablations, pulmonary artery denervation and disappearMelt.This Therapeutic Method avoids the hardship for opening breast of patient, and energy radical curing of disease, will not also cause any severe complication,Therefore extensively application is at home and abroad clinically had been obtained for.
But, be present a major defect in this traditional radio frequency ablation catheter, in order to reach deeper depth of ablation, faceHigher ablation energy can be used on bed, target spot site tissue hot-spot is so often caused and is caused incrustation, so as to shadowEffectiveness and the safety of operation are rung.
In order to reach deeper depth of ablation, can be while radio-frequency (RF) ablation, around radio-frequency ablation electrodeSprinkling cool brine, can so make ablation catheter reach deeper depth of ablation using higher power, while cool brine has againThe heat of radio-frequency ablation electrode is taken away, keeps being in suitable temperature around ablating electrode, reduced electrode surface incrustation and formedThe risk of thrombosis, improves safety and the effectiveness of operation.
But, prior art is generally using " cool brine " at 20-25 DEG C of room temperature（Also referred to as conventional normal saline）EnterRow perfusion of saline, from terms of existing clinical effectiveness, though surgical effect is improved relative to traditional ablation mode, in view of shouldThe cool brine of temperature takes away the finite energy of ablating electrode by heat exchange, causes lifting effect limited.
Authorization Notice No. discloses a kind of porous ablating electrode conduit for the Chinese utility model patent of CN201356648Y,There are multiple salt water holes, salt water hole is uniformly distributed along the axial direction of electrode, and salt water hole is divided into one and drains into three rows wherein on tip electrodeArrangement, can be with alignment or Heterogeneous Permutation between each row.The patent part improves the cooling-down effect of tip electrode, but usesPerfusion liquid is conventional saline infusions liquid, and achieved cooling-down effect is still limited.
The Chinese invention application of Publication No. CN102631240A discloses a kind of ablation catheter of multi-path brine channel,The passage of wherein perfusion of saline liquid has a plurality of, and certain brine channel therein is blocked, and is not interfering with other brine channels justOften work.This technology has certain economy, but it is conventional saline infusions liquid using liquid, electrode cooling-down effectIt is limited.
Authorization Notice No. discloses one kind and can automatically control saline filling for the Chinese utility model patent of CN201453373UThe rf ablation therapeutic instrument of note, including radiofrequency ablation therapy device, cold brine perfusion pump, foot switch, back pole plate and cool brineOpen irrigated ablation catheters, wherein, cold brine perfusion pump is connected by cable with radiofrequency ablation therapy device.Although which disclosingCharge pump 1 can be directly operated by user to adjust the manual mode of perfusion parameters, and by 3, radiofrequency ablation therapy deviceThe automated manner of the cool brine flow of charge pump 1 is controlled via control chip therein according to preset parameter.But, in this patentThe use of perfusion liquid is conventional normal saline, the perfusion parameters that can be adjusted are only limitted to cool brine flow without referring to cold saltCoolant-temperature gage.
Patent CN102688090A disclose it is a kind of it is two-way can hole perfusion of saline formula radio frequency ablation catheter for renal artery, whereinConduit has the function of two-way adjustable bending, and in the side wall of conduit, and it is conventional physiology salt using liquid for its salt mouth of a river perforateWater infusion liquid.
Patent CN102813552A discloses a kind of fixation side of the ablating electrode of perfusion of saline type electrophysiology ablation conduitMethod, wherein fill orifice are equably from the process of electrode distal end water spray, and it is conventional saline infusions liquid using liquid.
Can be seen from above, the cool brine under room temperature is generally used in prior art, and not recognized according to concrete targetThe pathological changes situation of point tissue and the requirement of depth of ablation adjusting the temperature of cool brine, therefore, when frequently occurring in ablation becauseCooling-down effect for cold brine perfusion is not enough, causes in order to avoid temperature is too high, and the ablation energy of applying is not enough, it is impossible to which offer is filledThe depth of ablation of foot, so as to the therapeutic effect for affecting to melt.
Accordingly, it would be desirable to a kind of cold brine perfusion ablation catheter system, the system includes cold brine perfusion ablation catheter, couplesThe radiofrequency generator for providing radio-frequency pulse energy to the conduit, the flow, integrated flow and the flow-sequential that are connected to the conduit to setIn at least one charge pump to transmit cool brine, it is characterised in that：The charge pump includes refrigeration part, sets for basisFixed temperature is freezed to cool brine.Within the system, charge pump has Automatic-cooling function, the physiology salt that can be used traditionWater freezes to suitable low temperature, is irrigated in ablation using the cool brine of low temperature, can more efficiently to ablating electrodeWashed away, preferably reduced the temperature of electrode surface, enough ablation energies can be applied, so as to more effectively provide ablationDepth.
The content of the invention
The invention provides a kind of cold brine perfusion ablation catheter system, including cold brine perfusion ablation catheter, it is coupled toIn the radiofrequency generator of conduit offer radio-frequency pulse energy, flow, integrated flow and the flow-sequential for being connected to the conduit to setAt least one charge pump to transmit cool brine, it is characterised in that：The charge pump includes refrigeration part, for according to settingTemperature to cool brine freeze.
The cold brine perfusion ablation catheter can be directly using existing various models with cold brine perfusion functionAblation catheter, in these conduits have brine channel, as low temperature cool brine circulation passage, be uniformly distributed on ablating electrodeThere are multiple salt water holes, each salt water hole can spray low temperature cool brine.The system can realize following Advantageous Effects：AdoptIt is irrigated in ablation with the cool brine of low temperature, more efficiently ablating electrode can be washed away, preferably reduces electricityThe temperature on pole surface, can apply enough ablation energies, so as to more effectively provide depth of ablation；Can regard treatment need according toThe appropriate refrigeration temperature of cool brine is set according to experience, so as to guarantee to lower the temperature and wash away and provide the same of enough depth of ablationWhen, it is also possible to save the energy expenditure needed for refrigeration；Additionally, the cold brine perfusion ablation catheter in the system can be adopted directlyThe cold brine perfusion ablation catheter of the various models sold on the market, it is radiofrequency generator and charge pump to need improved, is reduced wholeThe manufacturing cost and production difficulty of individual system.
The temperature of the cool brine can be-20-20 DEG C.Preferably, the temperature of cold brine perfusion liquid is-10-10 DEG C.For heart radio frequency ablation and renal artery ablation applications, it is preferable that the temperature of cold brine perfusion liquid is 0-8 DEG C.
At least one in the temperature and flow, integrated flow and flow-sequential can be straight on the charge pumpConnect setting；Can also by the radiofrequency generator communication be coupled to the charge pump, arrange on the radiofrequency generator temperature andAt least one in flow, integrated flow and flow-sequential, and couple and be transferred to the charge pump via the communication.DoctorAny of the above setting means can as needed be selected, such as it is sufficient in surgical staff and these personnel are familiar with charge pumpIn the case of operation, or in the case that the communication between radiofrequency generator and charge pump couples failure, root can be responsible for by personnelCarry out on charge pump directly setting above parameter according to the instruction of doctor so that doctor can concentrate one's energy perform conduit insertion,Ablation parameter is set on radiofrequency generator and ablation is performed；And if skilled staff relative deficiency or radiofrequency generator and charge pump away fromIn the case of causing doctor to take into account both settings farther out, above parameter, these parameters can be set on radiofrequency generatorThen couple via the communication and be transferred to charge pump and use for it.Preferably, the communication is coupled by wired or wireless wayAny one of to realize, wired mode includes cable connection, and wireless mode is coupled selected from bluetooth, radio frequency, infrared communication.
Preferably, the charge pump also includes feed pathway joint and liquid outlet channel joint, wherein the feed pathway connectsInfusion liquid source is connected to, the cool brine after refrigeration part refrigeration is transferred to the cold brine perfusion ablation and leads through the liquid outlet channelIn pipe.Preferably, be provided with filter in the charge pump, with filter refrigeration after cool brine in ice cube, so may insureThe cool brine being transferred to from charge pump in conduit is liquid.
Preferably, the cool brine after refrigeration part refrigeration is transferred to the cool brine through female Luer and saline connectorIn open irrigated ablation catheters.
Preferably, cool brine passage is provided with the cold brine perfusion ablation catheter, and is included sequentially by nearside to distallyThe handle of connection, main paragraph, curved segment and the ablating electrode that can be in curved segment can be arranged on, on the ablating electrode salt is provided withWater hole, the cool brine after refrigeration is transported to the salt water hole and is sprayed onto target spot position from it via the cool brine passage.It is excellentSelection of land, the near-end of the handle is provided with buttock line socket, and the buttock line socket is wired to the radiofrequency generator and is penetrated with receivingFrequency pulse energy.
According to the type and ablation scheme of target tissue, different cold brine perfusion ablation catheters can be selected, these are ledPipe can correspondingly using different structure ablating electrode and it is of different shapes can curved segment.Preferably, the ablating electrode bagContaining tip electrode and ring electrode, the salt water hole is opened on the tip electrode.Preferably, it is described can curved segment distal part for annularCircle, and the ablating electrode is the ring electrode being evenly distributed in annular ring.Preferably, it is described can curved segment at least distallyPart is spiral section, and the ablating electrode is the ring electrode being evenly distributed in the helical circumferential of the spiral section.
Description of the drawings
In order to more clearly describe technical scheme, briefly introduce below in conjunction with accompanying drawing.It is clear that thisA little accompanying drawings are only some specific embodiments that the application is recorded.Including but not limited to following these accompanying drawings of the invention.Hereinafter, cold brine perfusion ablation catheter is with the side of the side away from operator i.e. close target tissue as distally, andWith near operator side namely away from target tissue side as nearside.
Fig. 1 illustrates the schematic diagram of cold brine perfusion ablation catheter system according to an embodiment of the invention；
Fig. 2 is illustrated and disappeared according to a kind of cold brine perfusion of the cold brine perfusion ablation catheter system that can apply to the present inventionMelt conduit；
Fig. 3 illustrates another kind of cold brine perfusion according to the cold brine perfusion ablation catheter system that can apply to the present inventionAblation catheter；
Fig. 4 illustrates another cold brine perfusion according to the cold brine perfusion ablation catheter system that can apply to the present inventionAblation catheter；
Fig. 5 illustrates the schematic diagram of radiofrequency generator according to an embodiment of the invention；And
Fig. 6 illustrates the schematic diagram of cold brine perfusion pump according to an embodiment of the invention.
The explanation of reference
1, radiofrequency generator
101, impedance display
102, impedance setting
103, time showing
104, time setting
105, temperature shows
106, temperature setting
107, power shows
108, power setting
109, radiofrequency generator on and off switch
1010, conduit line jack
1011, external electrode line jack
1012, ride line jack
1013, electric discharge starts
1014, electric discharge terminates
1015, power mode
1016, temperature control mode
1017, linkage pattern
1018, radiofrequency generator linkage joint
1019, linkage pattern cool brine parameter setting module
1020, linkage pattern cool brine temperature shows
1021, the setting of linkage pattern cool brine temperature
1022, linkage pattern cool brine flow indication
1023, linkage pattern cool brine flow set
2, cold brine perfusion ablation catheter
201, can curved segment
202, tip electrode
203, salt water hole
204, main paragraph
205, handle function key
206, handle
207, buttock line socket
208, female Luer
209, saline connector
2010, ring electrode
211, annular ring
212, ring electrode
213, salt water hole
214, main paragraph
215, handle function key
216, handle
217, buttock line socket
218, female Luer
219, saline connector
2110, can curved segment
221, spiral section
222, ring electrode
223, salt water hole
224, main paragraph
225, handle function key
226, handle
227, buttock line socket
228, female Luer
229, saline connector
3, charge pump
301, temperature shows
302, temperature setting
303, refrigeration control switch
304, flow indication
305, flow set
306, integrated flow
307, integrated flow setting
308, charge pump on and off switch
309, liquid outlet channel joint
3010, feed pathway joint
3011, charge pump linkage joint
3012, temperature setting module
3013, parameter setting module
4, adnexa
401, external electrode
402, external electrode connecting line
403, conduit connecting line
404, ride connecting line
405, ride
406, saline connecting tube
407, saline connecting tube
408, infusion liquid source
409, train line
Specific embodiment
For a further understanding of the present invention, the preferred version of the present invention is described below in conjunction with embodiment.TheseDescription is merely illustrative the features and advantages of the present invention, rather than limits the scope of the invention.
Fig. 1 illustrates the schematic diagram of cold brine perfusion ablation catheter system according to an embodiment of the invention, such as Fig. 1 institutesShow, the system includes：Cold brine perfusion ablation catheter 2, radiofrequency generator 1, connection that conduit offer radio-frequency pulse energy is providedThe charge pump 3 of cool brine is transmitted with the flow and/or integrated flow of setting to the conduit 2, wherein, the charge pump 3 includesRefrigeration part, for being freezed to cool brine according to the temperature of setting, the example of the refrigeration part is in part described in conjunction with Figure 6In be given.
The system can realize following Advantageous Effects：It is irrigated in ablation using the cool brine of low temperature, canMore efficiently ablating electrode is washed away, the temperature of electrode surface is preferably reduced, enough ablation energies can be applied,So as to more effectively provide depth of ablation；Can need empirically to set the appropriate refrigeration temperature of cool brine depending on treatment, fromAnd while guaranteeing to lower the temperature and wash away and enough depth of ablation are provided, it is also possible to save the energy expenditure needed for refrigeration；Additionally,Cold brine perfusion ablation catheter in the system can directly using the cold brine perfusion ablation of the various models sold on the marketConduit（As illustrated in Fig. 2-4）, need it is improved be radiofrequency generator and charge pump, reduce whole system manufacturing cost andProduction difficulty.
The temperature and flow and/or integrated flow can directly set on the charge pump 3；Can also will be describedThe communication of radiofrequency generator 1 is coupled to the charge pump 3, and the temperature and flow and/or accumulative stream are arranged on the radiofrequency generator 1Amount, and couple and be transferred to the charge pump 3 via the communication.Doctor can as needed select any of the above setting sideFormula, such as in the case where surgical staff is sufficient and these personnel are familiar with the operation of charge pump 3, or in radiofrequency generator 1 and perfusionIn the case that communication between pump 3 couples failure, can be responsible for the instruction according to doctor directly to set on charge pump by personnelDetermine above parameter so that doctor can concentrate one's energy to perform conduit insertion, setting ablation parameter and execution on radiofrequency generatorAblation；And if skilled staff relative deficiency or radiofrequency generator 1 cause doctor to take into account both with charge pump 3 is distantIn the case of setting, above parameter can be set on radiofrequency generator 1 by doctor, these parameters then couple transmission via the communicationUse for it to charge pump 3.
Although hereinafter realizing the communication with the train line 409 of cable form to couple（As shown in Figure 1）, this is onlyThe illustration implementation that communication is coupled.Particularly, the communication is coupled and can realized by wired or wireless way, wiredMode includes the cable connection of such as train line 409, and wireless mode is selected from any during bluetooth, radio frequency, infrared communication are coupledKind.Using wireless mode, it is possible to reduce the line in system, so as to improving the flexibility ratio of system architecture and improving system operatioComfort level.The system can also include adnexa 4, the connector in adnexa 4, such as train line 409, for realizing conduit 2, penetratingFrequency instrument 1 and charge pump 3 coupling and/or connect each other, adnexa 4 also includes the external electrode that radiofrequency generator 1 generally needs401st, 405 and corresponding connector are ridden, also including charge pump 3 from the infusion liquid source of the cold brine perfusion liquid of its acquisition room temperature408。
Above-mentioned radiofrequency generator 1 can have various ways of realization, provide one of radiofrequency generator 1 with reference to Fig. 1 and Fig. 5 and showExample.
For example, the radiofrequency generator 1 is included：Switch module, mode selection module, parameter setting module.Wherein described switchModule starts 1013 and electric discharge end 1014 comprising on and off switch 109, electric discharge.Wherein described parameter setting module is included：ImpedanceSetting 102 shows that 105, power sets with time showing 103, temperature setting 106 with impedance display 101, time setting 104 with temperatureFixed 108 show 107, and linkage pattern cold brine perfusion setting module 1019, the cold brine perfusion setting module with power1019 show 1020, cool brine flow set 1023 and flow indication comprising linkage pattern cool brine temperature setting 1021 with temperature1022.Preferably, the mode selection module includes power mode 1015, temperature control mode 1016 and linkage pattern 1017.
Referring to Fig. 1 and Fig. 5, the radiofrequency generator 1 connects the conduit line jack on radiofrequency generator 1 by wire connecting line 4031010 with cold brine perfusion ablation catheter 2 on buttock line socket 207, be cold brine perfusion ablation catheter 2 provide radio-frequency pulse energyAmount；Connect the external electrode line jack 1011 and external electrode 401 on radiofrequency generator 1 by external electrode connecting line 402；Pass throughFoot-operated line jack 1012 and foot-operated 405 on the connection radiofrequency generator 1 of foot-operated connecting line 404." △ " in by impedance setting 102The higher limit of key assignments impedance, by the lower limit of its " ▽ " key assignments impedance, when impedance setting is carried out, resistance value is displayed inOn impedance display 101, the scope of impedance is in 50-1000 Ω, it is preferable that the scope of impedance is in 100-500 Ω.Set by the time" △ " key and " ▽ " key assignments radiofrequency generator 1 in fixed 104 discharges time of ablation, the model of the scope of ablation time at 1-999 secondsInterior any regulation is enclosed, ablation setting time shows in time showing 103, according to specific target spot position and institute in practical applicationDepth of ablation is needed, it is determined that corresponding ablation time.Temperature is protected by " △ " key and " ▽ " key assignments in temperature setting 106,Set protection temperature shows in temperature shows 105." △ " key and " ▽ " key in by power setting 108 is meltedPower setting, set power is displayed in power and shows in 107.The on and off switch 109 of radiofrequency generator controls whole radiofrequency generator 1Power supply.Radiofrequency generator 1 in the present embodiment has three kinds of mode of operations, respectively power mode 1015, temperature control mode 1016 and connectionDynamic model formula 1017.Preferably, the power mode 1015 provides constant pulse power for radiofrequency generator 1, can be constant in needsUse in the case of output radio-frequency power；Preferably, to be that radiofrequency generator 1 is provided simultaneous for power and temperature for the temperature control mode 1016Turn round and look at, discharge process can be protected in power and the aspect of temperature two.Temperature control mode 1016 is for clinically using most mouldsOne of formula, is also the discharge mode of the radiofrequency generator 1 that the present invention is recommended.Preferably, the linkage pattern 1017 be charge pump 3 withThe linkage work of radiofrequency generator 1, under linkage pattern, need to join the charge pump of the radiofrequency generator linkage joint 1018 of radiofrequency generator 1 and charge pump 3The communication of dynamic joint 3011 is coupled, and as an example, is coupled together by train line 409 in Fig. 1 and Fig. 6.Preferably, link mouldUnder formula 1017, the parameter of cool brine, and Jing can be set for charge pump 3 by linkage pattern cool brine parameter setting module 1019Coupled by the communication and set parameter is transferred to into charge pump 3.The parameter can be included using charge pump 3 to cool brineThe temperature and flow parameter of refrigeration, and can also preferably include the time sequence parameter of conveying cool brine, hereinafter setting systemIllustrate as a example by cold temperature and flow, but should be appreciated that preferably, in the whole operation for performing radio-frequency ablation procedureDuring, guide and insert during conduit 2 makes its step in place, the cold brine perfusion compared with low discharge is needed, in radio-frequency (RF) ablationThe 2-10 seconds are set to charge pump 3 to provide larger flow to continue to carry out larger flow in ablation procedure in advance before beginningPerfusion, and the conveying of cool brine is cut off after radio-frequency (RF) ablation terminates the 2-10 seconds, in order to provide more complete in whole operation processFace and appropriate cold brine perfusion, the parameter of cool brine can also include flow-time sequence parameter, the flow-time sequence parameterThe startup in each stage comprising cool brine conveying and termination time and the flow in each stage.
By taking the temperature and flow that set refrigeration as an example, in radiofrequency generator 1, by linkage pattern cool brine temperature 1021 are setIn " △ " key and the cool brine of perfusion needed for " ▽ " key assignments temperature, the temperature of the cool brine can be-20-20 DEG C,Preferably, the temperature of cold brine perfusion liquid is-10-10 DEG C；For heart radio frequency ablation and renal artery ablation applications,Preferably, the temperature of cold brine perfusion liquid is 0-8 DEG C.Preferably, in cold brine perfusion ablation catheter system with refrigeration after it is coldThe material of saline contacts using tolerance low temperature material prepare, these materials can be selected from polyurethane, polyethers, polyamide it is embeddingAny one of section copolymer, polyethylene, polypropylene, rustless steel, platinumiridio, gold, silver, Nitinol.
The charge pump 3 of cool brine can adopt various implementations, Fig. 1 and Fig. 6 to show an example of charge pump 3.For example, charge pump 3 can be included：Temperature setting module 3012, flow set module 3013, control module（Do not show in figureGo out）, internal refrigeration part（It is not shown in figure）, flow regulating part（It is not shown in figure）And related accessories.It is describedControl module is coupled to temperature setting module 3012 and flow set module 3013, to receive from it representing the temperature of setting respectivelyWith the data signal of flow；Be also coupled to the refrigeration part and flow regulating part, with respectively to its transmit for refrigeration andThe control signal of Flow-rate adjustment.
The flow regulating part is used to adjust the flow of normal saline, it is possible to which the stability of flow for keeping normal saline existsOn set flow.As an example, the flow regulating part can be realized by regulating valve, the regulating valve receive fromThe control signal for Flow-rate adjustment of control module output, goes to change fluid flow accordingly by power operation.Regulating valve oneAs be made up of actuator and valve, the valve can be using pneumatic operated valve, electrodynamic valve, hydraulic operated valve, electromagnetic valve etc..The refrigerationPart can adopt various different constructions.As an example, the refrigeration part includes five parts, respectively compressor, coldCondenser, expansion valve（That is " choke valve "）, vaporizer and connecting pipe.Liquid refrigerant, it is therefore preferable to freon, in vaporizerAfter absorbing the heat of normal saline, the steam of low-temp low-pressure is vaporized into, the freon is compressed into after the steam of High Temperature High PressureEductor condenser, within the condenser to cooling water heat release, is condensed into highly pressurised liquid, and warp knuckle stream valve is throttled in the fluorine of low-pressure low-temperatureIt is high, vaporizer heat absorption vaporization is again introduced into, reach the purpose of circularly cooling.So, freon in refrigeration systems through evaporation,Compression, condensation, four basic processes of throttling complete a kind of refrigeration cycle.Normal saline reaches and sets after refrigeration system refrigerationFixed temperature, particularly, transmits for the control signal of refrigeration, the control letter of the refrigeration from control module to refrigeration partNumber can pass through to adjust the power and flow etc. of the various pieces for constituting refrigeration part, the refrigeration needed for realizing normal saline.In practice it may happen that refrigeration after normal saline slightly offset from design temperature situation.Preferably, the physiology after refrigerationIt is provided with the stream of saline：Temperature sensor, for the temperature of real-time monitoring normal saline；And temperature adjustment module, it is used forWhen the temperature of monitoring produces deviation with design temperature, design temperature is adjusted the temperature to.The related accessories are included：Charge pump electricitySource switch 308, liquid outlet channel joint 309, feed pathway joint 3010, wherein the feed pathway joint 3010 is logical via feed liquorRoad（Such as saline connecting tube 407）It is connected to infusion liquid source 408 to receive from it without the room temperature cool brine for freezing, refrigeration part systemCool brine after cold is through the liquid outlet channel joint 3010 and the liquid outlet channel being attached thereto（Such as saline connecting tube 406）PassIt is defeated in the cold brine perfusion ablation catheter 2.
The temperature setting module 3012 is included：Refrigeration control switch 303, temperature setting 302, temperature shows 301, describedRefrigeration part can freeze according to the cryogenic temperature set in temperature setting 302 to cool brine, and temperature shows 301 thenShow by the temperature set by temperature setting 302.The flow set module 3013 is included：Flow set 305, flow indication304th, optional integrated flow setting 307 and optional integrated flow show 306, and flow indication 304 shows and passes through flow setFlow set by 305.The flow regulating part is adjusted after transmission refrigeration according to the flow set on flow set 305Cool brine flow.
Preferably, charge pump 3 includes effusion meter（Not shown in figure）Come measure transmission cool brine real-time traffic, and includingWith the crew-served flow totalizer of effusion meter（Not shown in figure）To calculate integrated flow, when it reaches integrated flow settingDuring the integrated flow set on 307, then the transmission for manually or automatically terminating cool brine can be reminded, the termination can pass through manyKind of mode for example turns off the power switch 308 realizing, or shut-off liquid outlet channel joint 309 etc..
Preferably, charge pump 3 is contained within filter（Do not indicate in figure）The saline ice cube therein of charge pump 3 can be filtered out,So that it is guaranteed that the cool brine after refrigeration is liquid, and being capable of the smooth circulation in infusion liquid passage.
Show that the cryogenic temperature to cool brine and flow and/or integrated flow set in Fig. 6, this as justExample.As above under linkage pattern 1017 on radiofrequency generator 1 for charge pump 3 setting cool brine parameter explanation,In order to provide in whole operation process more comprehensively with appropriate cold brine perfusion, on charge pump 3 directly setting cool brineThe parameter can also include flow-time sequence parameter, the flow-time sequence parameter comprising cool brine conveying each stage startupWith the time of termination and the flow in each stage.If also needing to set the flow-time sequence parameter of cool brine, it is outlined aboveRadiofrequency generator 1 and the composition of charge pump 3 need to be adjusted accordingly.For example, in charge pump 3, flow set module 3013 is modified toFlow-timing settings module, control module receives from it representing the data signal of flow-sequential；And pass to flow regulating partThe defeated control signal adjusted for flow-sequential, additionally, flow regulating part that the normal saline after freezing is had is setFlow-timing distribution.Additionally, the flow relevant parameter of set cool brine can be selected according to the demand of radio-frequency (RF) ablationAt least one in flow, integrated flow and flow-sequential, the He of radiofrequency generator 1 that can be according to selection result to being outlined aboveThe composition of charge pump 3 is adjusted accordingly.
Cold brine perfusion ablation catheter 2 in cold brine perfusion ablation catheter system of the invention can adopt variousType.
As depicted in figs. 1 and 2, cool brine is provided with a kind of cold brine perfusion ablation catheter 2 that can be applicable to the system to lead toRoad, and included the handle 206 for sequentially connecting, main paragraph 204, curved segment 201 and the bendable can be arranged on by nearside to distallyAblating electrode in section 201.Preferably, it is described as shown in Fig. 2 the ablating electrode includes tip electrode 202 and ring electrode 2010Salt water hole 203 is provided with tip electrode 202, the quantity in the salt water hole 203 is 7-80, a diameter of 0.02-0.5mm, it is preferable thatThere are 60 salt water holes 203, a diameter of 0.08mm in the salt water hole on tip electrode 202.Preferably, it is provided only with tip electrode in Fig. 1202 conduit 2 is applied to the situation for being not required to extract the signal of telecommunication in human body, is typically applied in renal artery denervation radio-frequency (RF) ablation.It is excellentSelection of land, the conduit shown in Fig. 2 is applicable to extract the situation of the signal of telecommunication in human body, is typically applied in radio-frequency (RF) ablation in heart,Concrete application is including but not limited to ARR radio-frequency (RF) ablation and lung in ARR radio-frequency (RF) ablation, ventricle in atriumTremulous pulse radio-frequency (RF) ablation and pulmonary vein radio-frequency (RF) ablation.Wherein it is preferred to, salt water hole 203 is divided into 8 rows distribution, has per salt discharge water hole 2037, there are 4 salt water holes 203 on the top of tip electrode 202（Do not indicate in figure）.Room temperature cool brine in infusion liquid source 408 is through saltAfter water connecting tube 407, charge pump 3 is sent into, charge pump 3 is via refrigeration part therein according to setting on temperature setting module 3012Fixed cryogenic temperature, by the cool brine that room temperature cool brine refrigeration is zero degree, and according to setting on charge pump 3 or radiofrequency generator 1Flow and/or integrated flow and/or flow-time sequence parameter, by the cool brine after refrigeration cold brine perfusion ablation catheter 2 is transported toIn.Cool brine after refrigeration is sequentially passed through（Can arrange can also be not arranged in cold brine perfusion ablation catheter 2）RuleHandle 206, main paragraph 204 in joint 208 and saline connector 209, cold brine perfusion ablation catheter 2 and can curved segment 201In cool brine passage（Do not indicate in figure）Tip electrode 202 is reached, then the salt water hole 203 from tip electrode 202 is equably sprayedThe target spot position specified into the human body is spilt, in radio-frequency (RF) ablation, the heat on tip electrode 202 can be effectively taken away, is being ensuredOn the premise of safety, the cool brine after refrigeration can be significantly better than the normal saline of room temperature for the cooling-down effect of tip electrode.So thatIn electric discharge ablation, the temperature for melting target spot position will not be too high, can keep the temperature at 27 DEG C or so, and this temperature is less than37 DEG C of the normal body temperature of human body, the application risk for substantially reducing radio-frequency (RF) ablation and the comfort level for improving patient.In 27 DEG C of temperature,The surface of tip electrode 202 will not form incrustation, can substantially reduce the surface of tip electrode 202 and form thrombotic risk.In ablation target spotTemperature is maintained under the premise of 27 DEG C, and cold brine perfusion ablation catheter system of the present invention can disappear than traditional perfusion of salineMelt the power increase by 10% -50% that conduit is used such that it is able to guarantee the depth of ablation of abundance and then guarantee controlling for ablative surgeryTherapeutic effect.
Fig. 3 shows another kind of cold brine perfusion ablation catheter 2, mainly exists with conduit difference shown in Fig. 1 and Fig. 2In, the conduit can the distal part of curved segment 2110 be annular ring 211, and the ablating electrode is ring electrode 212, is uniformly distributedIn annular ring 211, salt water hole 213 is provided with ring electrode 212.Preferably, the quantity in the salt water hole is 12, is divided into2 rows are distributed, two row's malposition of electrode arranged distributions.A diameter of 0.2mm in shown salt water hole 213.It is described can curved segment 2110 can lead toThe handle function key 215 crossed on handle 216 realizes that control is curved.The near-end of handle 216 is provided with：Buttock line socket 217, for by wire403（As shown in Figure 1）It is connected to radiofrequency generator 1 to receive radio-frequency pulse energy；And female Luer 218 and saline connector 219,For connecting charge pump 3, cool brine passage of the cool brine after refrigeration in cold brine perfusion ablation catheter 2（Do not mark in figureShow）It is delivered on ring electrode 212, is then equably sprayed onto target tissue from salt water hole 213.
Fig. 4 shows another cold brine perfusion ablation catheter 2, is with conduit difference shown in Fig. 1 and Fig. 2,It is described can curved segment at least distal part be spiral section 221, the ablating electrode be evenly distributed on spiral section 221 spiral weekRing electrode 222 upwards, is provided with salt water hole 223 on the ring electrode 222.Preferably, the salt water hole on the ring electrode 222223 quantity is 40, is divided into 4 rows distribution, and often row is evenly distributed with 10 salt water holes, and adjacent two salt discharges water hole 223 is in dislocationArrangement.Preferably, a diameter of 0.1mm in each salt water hole 223.Cool brine after being freezed using charge pump 3, sequentially passes through RuleJoint 228, saline connector 229, handle 226, main paragraph 224 and can be in curved segment brine channel（Do not indicate in figure）It is delivered toOn ring electrode 222, then equably it is sprayed on target tissue from salt water hole 223.When the system melts, target spot temperature can dropIt is low to be in close proximity to 37 DEG C of body temperature to 35 DEG C or so, the surface of ring electrode 222 incrustation risk is greatly reduced, improve operationSuccess rate.
As shown in Figure 1, Figure 2, Figure 3, Figure 4, cold brine perfusion ablation catheter 2 adopts in systems same connection sideFormula.The cold brine perfusion ablation catheter that cold brine perfusion ablation catheter system of the present invention is suitable for is including but not limited to this realityApply the conduit described in example.The electrophysiologicalcatheter catheter of other similar applications is equally applicable.
The present invention is not limited to the particular content described in specific embodiment.The invention provides a kind of cool brine is filledNote ablation catheter system, can apply to electrophysiologicalcatheter catheter, it is preferable that lead suitable for heart cold brine perfusion type radio-frequency (RF) ablationPipe, renal artery cold brine infusion type radiofrequency ablation catheter, pulmonary artery cold brine infusion type radiofrequency ablation catheter, pulmonary vein cool brinePouring type radio frequency ablation catheter.Equally, cold brine perfusion ablation catheter system of the present invention is also applied for body vessels, human bodyDisease treatment in tissue, such as cervical cancer cold brine infusion type radiofrequency ablation catheter etc..
The explanation of above example is only intended to the core concept for helping understand the present invention.It should be pointed out that for this areaThose of ordinary skill for, under the premise without departing from the principles of the invention, the present invention can also be carried out it is some improvement and repairDecorations, but these are improved and modification is also fallen in the range of the claims in the present invention are claimed.