[background technology]
Paeonol has another name called paeonol, and white crystals body, is insoluble in water, fusing point 52-53 DEG C, being the principle active component of Chinese medicine Cortex Moutan and Radix Cynanchi Paniculati, is that a kind of daily use chemicals additive of Nantural non-toxic has biological activity widely, as anti-inflammation, analgesia, antitumor and prevention cardiovascular system diseases etc.Pharmacological research finds that paeonol all has obvious inhibitory action to esophageal carcinoma, hepatocarcinoma, colon cancer, leukemia etc., has good antibacterial anti-inflammatory, antipyretic-antalgic, anticoagulation, antiallergic, immunomodulating, atherosclerosis and suppresses the effects such as central nervous system.Paeonol blood circulation promoting and blood stasis dispelling, promotes that microcirculatory effect is obviously better than aspirin.
[summary of the invention]
Feature of the present invention is to use non-ionic surface active agent glycerin polyether as carrier, manufactures paeonol glycerin polyether complex.
The present invention, by the complexation of glycerin polyether, changes the physical property of paeonol, and from the water that is insoluble in of paeonol, to become arbitrary proportion water-soluble.
The present invention is the intermediate manufacturing treatment rheumatism, skin pruritus treatment medicine gel, is manufacture beautifying face, and hair is anti-dandruff, the intermediate of only overworked, hair growth promoter and lotion.
The present invention's complex used carrier glycerin polyether has excellent dissolubility, wettability, compatibility.Glycerin polyether is widely used in the various fields such as household chemicals, food industry, pharmacy industry.Glycerin polyether toxicity is extremely low, to human body skin and human body mucosa nonirritant.
Glycerin polyether molecular weight of the present invention needs to control at 1600-2500.
The present invention, under valid density, has good bactericidal effect to multiple-microorganisms such as Staphylococcus aureus bacillus, escherichia coli, fungus, mycetes.
The synthesis of paeonol glycerin polyether complex of the present invention completed in particular device, temperature, time response process; Device therefor is rustless steel (or enamel or glass) material, and reactor need be air-tight state, need material circulation equipment and firing equipment.Reaction temperature controls between 50-100 DEG C, and the material synthetic system pH value in building-up process is faintly acid.
Material composition of the present invention: glycerin polyether 90-95 part, paeonol 5-10 part, citric acid 0.5-1.0 part.
The present invention is with in temperature controlled chuck stainless steel cauldron, add glycerin polyether, be warming up to 50 ± 2 DEG C and add citric acid, be warming up to 60 ± 2 DEG C and add paeonol, reactor synthetic reaction is after 1 hour, temperature is down to 35 ± 2 DEG C, after testing qualified rear discharging, and material is placed in lucifuge, nonmetallic container.
Outward appearance body shape of the present invention is light yellow thick liquid, water-soluble, ethanol, isopropyl alcohol, acetone, pH value (1% aqueous solution): 5-7, moisture content (%) :≤1.0, viscosity (25 DEG C of CPS): 250-400, paeonol content 5-10%.
The present invention manufactures that raw material is easy to get, pollution-free in production process, without garbage, the requirement meeting environmental protective chemical industry production technology.
[detailed description of the invention]
Embodiment one:
By following part by weight throwing raw materials: glycerin polyether 89 parts, paeonol 10 parts, citric acid 1 part.
Synthesis route: with in temperature controlled airtight stainless steel cauldron, add glycerin polyether 89 kilograms, is warming up to 50 ± 2 DEG C and adds citric acid 1 kilogram; Heat up 60 ± 2 DEG C and add paeonol 10 kilograms; 1 hour reactor response time.Temperature is down to 35 ± 2 DEG C, after testing qualified rear discharging.Material is placed in lucifuge, nonmetallic container.
Embodiment two:
By following part by weight throwing raw materials: glycerin polyether 94.5 parts, paeonol 5 parts, citric acid 0.5 part.
Synthesis route: with in temperature controlled airtight stainless steel cauldron, add glycerin polyether 94.5 kilograms, is warming up to 50 ± 2 DEG C and adds citric acid 0.5 kilogram; Heat up 60 ± 2 DEG C and add paeonol 5 kilograms; 1 hour reactor response time.Temperature is down to 35 ± 2 DEG C of qualified rear dischargings after testing.Material is placed in lucifuge, nonmetallic container.