CN103760373A - Cleaning device in fully-automatic chemiluminescence immunity analyzer - Google Patents

Abstract

Translated fromChinese

本发明为全自动化学发光免疫分析仪中的清洗装置，包括：第一圆盘，由驱动机构带动旋转，且第一圆盘的周缘部分设置有间隔排列的多个分析容器，在分析容器中投放有用于吸附待检测体液样本的磁性微球；第二圆盘，同轴地设置在旋转盘的上方，且第二转盘的直径小于第一转盘的直径，第二圆盘的周缘部分设置有间隔排列的多个电磁体；清洗件，其设置在第一圆盘的一侧，且与第二圆盘的多个电磁体中的至少一个相对；其中，第一圆盘转动，带动第一圆盘上的分析容器选择性地停留在清洗件处。本案的清洗装置只需一个旋转圆盘和若干电磁铁，就能够实现根据需要选择的控制各分析容器中的磁性微球处于吸附状态还是非吸附状态，极大地提高了清洗效率。

The present invention is a cleaning device in a full-automatic chemiluminescence immunoassay analyzer, comprising: a first disk driven to rotate by a driving mechanism, and a plurality of analysis containers arranged at intervals are arranged on the peripheral part of the first disk, and in the analysis container The magnetic microspheres for absorbing the body fluid sample to be detected are placed; the second disk is coaxially arranged above the rotating disk, and the diameter of the second rotating disk is smaller than the diameter of the first rotating disk, and the peripheral part of the second disk is provided with A plurality of electromagnets arranged at intervals; a cleaning element, which is arranged on one side of the first disc, and is opposite to at least one of the plurality of electromagnets of the second disc; wherein, the rotation of the first disc drives the first The analysis containers on the disc are selectively parked on the wash piece. The cleaning device in this case only needs one rotating disc and several electromagnets, and can control whether the magnetic microspheres in each analysis container are in the adsorption state or the non-adsorption state according to the needs, which greatly improves the cleaning efficiency.

Description

Translated fromChinese

一种全自动化学发光免疫分析仪中的清洗装置A cleaning device in a fully automatic chemiluminescence immunoassay analyzer

技术领域technical field

本发明涉及一种体外检测领域的医疗器械，特别是涉及一种采用磁性微球作为反应载体的全自动化学发光免疫分析仪中的清洗装置。The invention relates to a medical device in the field of in vitro detection, in particular to a cleaning device in a fully automatic chemiluminescence immunoassay analyzer using magnetic microspheres as a reaction carrier.

背景技术Background technique

全自动化学发光免疫分析仪是一种可对患者的体液样本进行免疫学定量分析的仪器，可检验贫血、心血管疾病、先天性疾病、性激素、传染病、代谢功能、肿瘤标志物、治疗药物监控和甲状腺等疾病。全自动化学发光免疫分析仪的应用，使检验过程完全实现自动化，提高了免疫分析的工作效率，消除了人为的主观误差，稳定了免疫检验的质量，为临床免疫分析提供了一条可靠而高效的途径。The automatic chemiluminescent immunoassay analyzer is an instrument that can perform immunological quantitative analysis on patient's body fluid samples, and can test anemia, cardiovascular disease, congenital diseases, sex hormones, infectious diseases, metabolic functions, tumor markers, therapeutic drugs Monitor and thyroid and other diseases. The application of automatic chemiluminescence immunoassay analyzer makes the inspection process fully automatic, improves the work efficiency of immunoassay, eliminates human subjective error, stabilizes the quality of immunoassay, and provides a reliable and efficient method for clinical immunoassay. way.

在采用磁性微球作为反应载体的全自动化学发光免疫分析仪中，通常同时使用多个一次性反应杯作为反应容器。这些反应杯彼此间隔地设置在圆盘的周围。设置多个反应杯的目的是为了提高分析效率，可以同时在不同的反应杯里面展开不同人的样本的不同反应操作。而在向反应杯内加入待分析的体液样本后，再向反应杯中加入含有吸附有抗原或抗体的微米或纳米级的磁性微球的反应试剂。试剂中的磁性微球悬浮于试剂中。在样本与试剂的孵育反应完成后，需要进行清洗，去除未反应的体液样本和试剂，只留下反应后的以磁性微球作为固相载体的复合物。In an automatic chemiluminescent immunoassay analyzer using magnetic microspheres as reaction carriers, multiple disposable cuvettes are usually used as reaction containers at the same time. These cuvettes are arranged at intervals around the disk. The purpose of setting multiple cuvettes is to improve the analysis efficiency, and different reaction operations of samples from different people can be carried out in different cuvettes at the same time. After the body fluid sample to be analyzed is added into the cuvette, a reaction reagent containing micron or nanoscale magnetic microspheres adsorbed with antigens or antibodies is added into the cuvette. The magnetic microspheres in the reagent are suspended in the reagent. After the incubation reaction between the sample and the reagent is completed, it needs to be washed to remove the unreacted body fluid sample and reagent, leaving only the reacted complex with magnetic microspheres as the solid phase carrier.

在清洗时，通过转动圆盘，使得待清洗的反应杯转到清洗机构下方，而在清洗机构的对面设置有永磁体，永磁体通过磁场作用，使得磁性微球向永磁体方向运动，而最终被反应杯的杯壁所阻挡，最终附着在反应杯靠近永磁体一侧的杯壁内侧。这时候用清洗机构上的吸液针深入到反应杯底部，把反应杯中包含液体样本，以及未反应的试剂在内的所有液体抽掉。而磁性微球固相载体由于吸附在杯壁上，不会被带走。之后，清洗机构再通过注液针向反应杯中注入清洗液，对磁性微球作为固相载体的复合物进行清洗。之后将清洗液抽出，多次重复后，完成整个清洗过程。During cleaning, the cuvettes to be cleaned are transferred to the bottom of the cleaning mechanism by rotating the disc, and a permanent magnet is arranged on the opposite side of the cleaning mechanism. It is blocked by the cup wall of the cuvette, and finally attached to the inner side of the cuvette wall near the permanent magnet side. At this time, use the aspiration needle on the cleaning mechanism to go deep into the bottom of the cuvette, and suck out all the liquid in the cuvette including the liquid sample and unreacted reagents. The magnetic microsphere solid phase carrier will not be taken away because it is adsorbed on the cup wall. Afterwards, the cleaning mechanism injects cleaning solution into the cuvette through the liquid injection needle to clean the composite of the magnetic microspheres as the solid phase carrier. Afterwards, the cleaning liquid is drawn out, and after repeated several times, the whole cleaning process is completed.

但是现有技术存在以下缺陷：1)在对磁性微球固相载体进行清洗的时候，由于其附着在杯壁上，除磁性微球层表面外的其他磁性微球难以进行充分地清洗，导致清洗不充分。2)磁性微球悬浮于液体中，即使在永磁体的磁场作用，整个吸附过程通常需要数十秒，极大地影响了工作效率。而如果在圆盘的转动路径上设置多块永磁体，虽然能够让待清洗的反应杯中的磁性微球在圆盘转动的过程中完成吸附过程，但是由于圆盘上设置有多个反应杯，这些永磁体也会对其它可能正在反应过程中的反应杯造成不当的磁场干扰。因为在反应过程中，是不应当施加磁场的，而只有吸附磁性微球，及吸出清洗液的过程中，才需要施加磁场。But the following defects exist in the prior art: 1) when the magnetic microsphere solid phase carrier is cleaned, because it is attached on the cup wall, other magnetic microspheres except the surface of the magnetic microsphere layer are difficult to clean sufficiently, resulting in Inadequate cleaning. 2) The magnetic microspheres are suspended in the liquid. Even under the action of the magnetic field of the permanent magnet, the entire adsorption process usually takes tens of seconds, which greatly affects the work efficiency. And if a plurality of permanent magnets are set on the rotation path of the disk, although the magnetic microspheres in the cuvette to be cleaned can be completed in the process of the rotation of the disk, the magnetic microspheres can be absorbed due to the fact that the cuvette is provided with a plurality of cuvettes. , these permanent magnets can also cause undue magnetic disturbance to other cuvettes that may be in progress. Because in the reaction process, the magnetic field should not be applied, but only in the process of adsorbing the magnetic microspheres and sucking out the cleaning solution, the magnetic field needs to be applied.

发明内容Contents of the invention

为克服现有技术的不足，本发明的目的在于提供一种全自动化学发光免疫分析仪中的清洗装置，使磁性微球在清洗时磁场能被去除，磁性微球可以得到充分清洗，而不至因被吸附在杯壁上，导致清洗不完全。In order to overcome the deficiencies in the prior art, the purpose of the present invention is to provide a cleaning device in a fully automatic chemiluminescence immunoassay analyzer, so that the magnetic field can be removed when the magnetic microspheres are cleaned, and the magnetic microspheres can be fully cleaned without As a result of being adsorbed on the cup wall, the cleaning is not complete.

本发明的另一个目的在于提供一种能够根据反应杯中反应是否完成而独立决定是否加载磁场以提高使用效率的清洗装置。Another object of the present invention is to provide a cleaning device that can independently decide whether to apply a magnetic field according to whether the reaction in the cuvette is completed, so as to improve the use efficiency.

为实现上述目的，本发明通过以下技术方案实现：To achieve the above object, the present invention is achieved through the following technical solutions:

一种全自动化学发光免疫分析仪中的清洗装置，包括：A cleaning device in a fully automatic chemiluminescence immunoassay analyzer, comprising:

第一圆盘，其由驱动机构带动旋转，且所述第一圆盘的周缘部分设置有间隔排列的多个分析容器，在分析容器中投放有用于吸附待检测体液样本的磁性微球；The first disk is driven to rotate by the driving mechanism, and the peripheral part of the first disk is provided with a plurality of analysis containers arranged at intervals, and magnetic microspheres for absorbing the body fluid sample to be detected are placed in the analysis containers;

第二圆盘，其同轴地设置在所述第一圆盘的上方，且所述第二圆盘的直径小于所述第一圆盘的直径，所述第二圆盘的周缘部分设置有间隔排列的多个电磁体；A second disk, which is coaxially arranged above the first disk, and the diameter of the second disk is smaller than the diameter of the first disk, and the peripheral portion of the second disk is provided with a plurality of electromagnets arranged at intervals;

清洗件，其设置在所述第一圆盘的一侧，且与所述第二圆盘的多个电磁体中的至少一个相对；a cleaning element disposed on one side of the first disc and opposite to at least one of the plurality of electromagnets of the second disc;

其中，第一圆盘转动，以带动第一圆盘上的分析容器选择性地停留在清洗件处。Wherein, the first disk rotates to drive the analysis containers on the first disk to selectively stop at the cleaning part.

优选的是，所述的全自动化学发光免疫分析仪中的清洗装置，所述驱动机构采用同步带传动机构，其包括电机、同步带、同步带轮，所述第一圆盘的外沿设有与所述同步带啮合的齿，所述电机的输出端连接所述同步带轮，所述同步带轮通过所述同步带与所述第一圆盘的齿相连，所述电机通过同步带控制所述第一圆盘选择性地转动或停留。Preferably, in the cleaning device in the fully automatic chemiluminescent immunoassay analyzer, the drive mechanism adopts a synchronous belt transmission mechanism, which includes a motor, a synchronous belt, and a synchronous pulley, and the outer edge of the first disc is provided with There are teeth meshing with the synchronous belt, the output end of the motor is connected to the synchronous pulley, the synchronous pulley is connected with the teeth of the first disc through the synchronous belt, and the motor is connected to the tooth of the first disc through the synchronous belt. The first disc is controlled to selectively rotate or stay.

优选的是，所述的全自动化学发光免疫分析仪中的清洗装置，所述多个分析容器彼此之间的间隔与所述多个电磁体彼此之间的间隔相等。Preferably, in the cleaning device in the automatic chemiluminescence immunoassay analyzer, the intervals between the plurality of analysis containers are equal to the intervals between the plurality of electromagnets.

优选的是，所述的全自动化学发光免疫分析仪中的清洗装置，所述清洗件包括：Preferably, the cleaning device in the fully automatic chemiluminescence immunoassay analyzer, the cleaning parts include:

支撑架，包括底座和顶座，所述顶座上设有升降台；The support frame includes a base and a top seat, and the top seat is provided with a lifting platform;

吸液针，其设置在所述升降台上，并通过所述升降台向下方竖直延伸；A liquid suction needle, which is arranged on the lifting platform and extends vertically downward through the lifting platform;

注液针，其与所述吸液针并排设置在所述升降台上，并通过所述升降台向下方延伸，所述注液针朝所述电磁体方向倾斜；a liquid injection needle, which is arranged side by side with the liquid suction needle on the lifting platform, and extends downward through the lifting platform, and the liquid injection needle is inclined toward the direction of the electromagnet;

清洗液容器，其与所述注液针通过管路连通，且在管路上设置有液泵；A cleaning liquid container, which communicates with the liquid injection needle through a pipeline, and a liquid pump is arranged on the pipeline;

排放管，其与所述吸液针连通，且在管路上设置有液泵。A discharge pipe communicates with the liquid suction needle, and a liquid pump is arranged on the pipe.

优选的是，所述的全自动化学发光免疫分析仪中的清洗装置，所述分析容器为上方开口的筒罐，当分析容器停留在清洗件处时，吸液针、注液针与筒罐开口相对。Preferably, in the cleaning device in the fully automatic chemiluminescence immunoassay analyzer, the analysis container is a canister with an upper opening. The opening is opposite.

优选的是，所述的全自动化学发光免疫分析仪中的清洗装置，所述第二圆盘的整个周缘部分均设置有间隔排列的多个电磁体，且所述清洗装置还包括：Preferably, in the cleaning device in the fully automatic chemiluminescence immunoassay analyzer, the entire peripheral portion of the second disc is provided with a plurality of electromagnets arranged at intervals, and the cleaning device further includes:

控制器，单独控制每个电磁体的通断电。The controller controls the power on and off of each electromagnet individually.

优选的是，所述的全自动化学发光免疫分析仪中的清洗装置，当所述控制器控制液泵，使得吸附过程中及吸液针吸液时，与待清洗分析容器相对应的电磁体通电，而当所述控制器控制液泵，使得注液针注液时，与待清洗分析容器相对应的电磁体断电。Preferably, in the cleaning device in the fully automatic chemiluminescence immunoassay analyzer, when the controller controls the liquid pump, the electromagnet corresponding to the analysis container to be cleaned will When the controller controls the liquid pump so that the liquid injection needle injects liquid, the electromagnet corresponding to the analysis container to be cleaned is powered off.

优选的是，所述的全自动化学发光免疫分析仪中的清洗装置，还包括：Preferably, the cleaning device in the fully automatic chemiluminescence immunoassay analyzer also includes:

计时器，其计算每个分析容器的反应时间，且所述计时器与所述控制器通讯连接，当控制器接收到的一个分析容器的反应时间超过设定值，则判定为该分析容器内的反应结束；A timer, which calculates the reaction time of each analysis container, and the timer is connected with the controller in communication. When the response time of an analysis container received by the controller exceeds the set value, it is determined that the analysis container is The reaction ends;

定位器，其定位在第一转盘转动的过程中，每个分析容器所处的位置；a positioner, which is used to locate the position of each analysis container during the rotation of the first turntable;

若控制器判断一分析容器内的反应结束，则根据定位器的定位，启动其相对的电磁体通电；而若控制器判断一分析容器内的反应正在进行，则根据定位器的定位，使其相对的电磁体断电。If the controller judges that the reaction in an analysis container is over, then according to the positioning of the locator, start its corresponding electromagnet to energize; The opposing electromagnet is de-energized.

优选的是，所述的全自动化学发光免疫分析仪中的清洗装置，所述磁性微球为纳米级磁性微球。Preferably, in the cleaning device in the automatic chemiluminescence immunoassay analyzer, the magnetic microspheres are nano-scale magnetic microspheres.

本发明的有益效果是：1)可以只需一层可自由旋转的圆盘，简化了仪器结构；2)电磁铁的引入使得磁场易于掌控，在注入清洗液体的同时，能够自动去除或调整磁场，使磁性微球得到充分清洗；3)能够使得反应完成的反应杯在尚未到达清洗件之前，就受到磁场吸引，开始吸附过程，以节约到达清洗机后的吸附时间，而反应未完成的反应杯不受到磁场吸引。The beneficial effects of the present invention are: 1) only one layer of freely rotatable discs is needed, which simplifies the instrument structure; 2) the introduction of the electromagnet makes the magnetic field easy to control, and the magnetic field can be automatically removed or adjusted when the cleaning liquid is injected , so that the magnetic microspheres are fully cleaned; 3) the cuvette that has completed the reaction can be attracted by the magnetic field before reaching the cleaning piece, and the adsorption process starts, so as to save the adsorption time after reaching the washing machine, while the reaction that has not completed the reaction The cup is not attracted by the magnetic field.

附图说明Description of drawings

图1为本发明所述的全自动化学发光免疫分析仪中的清洗装置的俯视图。Fig. 1 is a top view of the cleaning device in the fully automatic chemiluminescence immunoassay analyzer of the present invention.

具体实施方式Detailed ways

下面结合附图对本发明做进一步的详细说明，以令本领域技术人员参照说明书文字能够据以实施。The present invention will be further described in detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

全自动化学发光免疫分析仪的检验过程的步骤包括：加载反应杯、加样本、加试剂、孵育反应、清洗分离、加注激发液、发光信号检测和检测结果计算等。The steps of the inspection process of the automatic chemiluminescent immunoassay analyzer include: loading reaction cups, adding samples, adding reagents, incubating reactions, washing and separating, filling excitation solutions, luminescent signal detection and calculation of test results, etc.

对于采用转盘传动的全自动化学发光免疫分析仪来说，根据不同产品的设计结构，有时样本试剂加样部、装载部、孵育部、清洗部这几个部分中会公用一些部件，如转盘等。For the fully automatic chemiluminescence immunoassay analyzer using the turntable drive, according to the design structure of different products, sometimes some parts are shared in the sample reagent loading part, loading part, incubation part and cleaning part, such as the turntable, etc. .

请参见图1，其说明本发明一实施例的一种全自动化学发光免疫分析仪中的用于清洗分离的清洗装置，它包括：第一圆盘1；第二圆盘2；电磁体3；清洗件4；分析容器5。Please refer to Fig. 1, which illustrates a cleaning device for cleaning and separating in a fully automatic chemiluminescence immunoassay analyzer according to an embodiment of the present invention, which includes: a first disc 1; asecond disc 2; anelectromagnet 3 ;Cleaning piece 4 ;Analytical container 5 .

第一圆盘1是旋转盘，其由驱动机构带动旋转，它的周缘部分设置有间隔排列的多个分析容器5，在分析容器5中投放有用于吸附待检测体液样本的纳米级磁性微球；本案中驱动机构采用同步带传动机构，其包括电机、同步带、同步带轮，第一圆盘的外沿设有与同步带啮合的齿，电机的输出端连接同步带轮，同步带轮通过同步带与第一圆盘的齿相连，电机通过同步带控制第一圆盘选择性地转动或停留。The first disk 1 is a rotating disk, which is driven to rotate by a driving mechanism, and its peripheral part is provided with a plurality ofanalysis containers 5 arranged at intervals, and nano-scale magnetic microspheres for absorbing body fluid samples to be detected are placed in theanalysis containers 5 ; In this case, the driving mechanism adopts a synchronous belt transmission mechanism, which includes a motor, a synchronous belt, and a synchronous pulley. The teeth of the first disc are connected through the timing belt, and the motor controls the first disc to selectively rotate or stay through the timing belt.

第二圆盘2是固定盘，其同轴地设置在第一圆盘1的上方，且第二圆盘2的直径小于第一圆盘1的直径，第二圆盘2的整个周缘部分均设置有间隔排列的多个电磁体3；多个分析容器5彼此之间的间隔与多个电磁体3彼此之间的间隔相等。Thesecond disk 2 is a fixed disk, which is coaxially arranged above the first disk 1, and the diameter of thesecond disk 2 is smaller than the diameter of the first disk 1, and the entire peripheral portion of thesecond disk 2 is A plurality ofelectromagnets 3 arranged at intervals is provided; the interval between the plurality ofanalysis containers 5 is equal to the interval between the plurality ofelectromagnets 3 .

清洗件4，其设置在第一圆盘1的一侧，且与第二圆盘2的多个电磁体3中的至少一个相对；清洗件4包括：Thecleaning part 4 is arranged on one side of the first disc 1 and is opposite to at least one of the plurality ofelectromagnets 3 of thesecond disc 2; thecleaning part 4 includes:

支撑架，包括底座和顶座，顶座上设有升降台；The support frame includes a base and a top seat, and a lifting platform is arranged on the top seat;

吸液针，其设置在升降台上，并通过升降台向下方竖直延伸；The liquid suction needle is arranged on the lifting platform and extends vertically downward through the lifting platform;

注液针，其与吸液针并排设置在升降台上，并通过升降台向下方延伸，注液针朝电磁体方向倾斜；The liquid injection needle is arranged side by side with the liquid suction needle on the lifting platform, and extends downward through the lifting platform, and the liquid injection needle is inclined towards the direction of the electromagnet;

清洗液容器，其与注液针通过管路连通，且在管路上设置有液泵；A cleaning liquid container, which communicates with the liquid injection needle through a pipeline, and a liquid pump is arranged on the pipeline;

排放管，其与吸液针连通，且在管路上设置有液泵。The discharge pipe communicates with the liquid suction needle, and a liquid pump is arranged on the pipe.

第一圆盘1转动，以带动第一圆盘1上的分析容器5选择性地停留在清洗件处。分析容器5为上方开口的筒罐，当分析容器5停留在清洗件4处时，吸液针、注液针与筒罐开口相对。The first disk 1 rotates to drive theanalysis containers 5 on the first disk 1 to selectively stop at the cleaning parts. Theanalysis container 5 is a canister with an upper opening. When theanalysis container 5 stays at thecleaning part 4, the liquid suction needle and liquid injection needle are opposite to the opening of the canister.

该清洗装置还包括：The cleaning unit also includes:

控制器，单独控制每个电磁体的通断电。当所述控制器控制液泵，使得吸附过程中及吸液针吸液时，与待清洗的分析容器相对应的电磁体通电，而当所述控制器控制液泵，使得注液针注液时，与待清洗的分析容器相对应的电磁体断电。The controller controls the power on and off of each electromagnet individually. When the controller controls the liquid pump, the electromagnet corresponding to the analysis container to be cleaned is energized during the adsorption process and when the liquid suction needle absorbs liquid, and when the controller controls the liquid pump, the liquid injection needle injects liquid , the electromagnet corresponding to the analysis container to be cleaned is de-energized.

计时器，其计算每个分析容器的反应时间，且计时器与控制器通讯连接，当控制器接收到的一个分析容器的反应时间超过设定值，则判定为该分析容器内的反应结束；A timer, which calculates the reaction time of each analysis container, and the timer is connected with the controller in communication, when the response time of an analysis container received by the controller exceeds the set value, it is determined that the reaction in the analysis container is over;

定位器，其定位在第一转盘转动的过程中，每个分析容器所处的位置；a positioner, which is used to locate the position of each analysis container during the rotation of the first turntable;

若控制器判断一分析容器内的反应结束，则根据定位器的定位，启动其相对的电磁体通电；而若控制器判断一分析容器内的反应正在进行，则根据定位器的定位，使其相对的电磁体断电。If the controller judges that the reaction in an analysis container is over, then according to the positioning of the locator, start its corresponding electromagnet to energize; The opposing electromagnet is de-energized.

对应采用转盘传动方式的化学发光免疫分析仪来说，一般在等待磁性微球吸附的过程中，第一圆盘1间隔一定时间会自动旋转，移至另一工作位置，进行相应的操作，而在旋转过程中，与待清洗的需提供磁场的分析容器5对应的电磁体3的个体将不断变化，通过切换电磁体3个体的供电达到电磁场与分析容器5相对同步的作用效果，以保证其吸附效果。Corresponding to the chemiluminescent immunoassay analyzer adopting the turntable transmission mode, generally in the process of waiting for the magnetic microspheres to be adsorbed, the first disk 1 will automatically rotate at intervals of a certain period of time, and move to another working position to perform corresponding operations. During the rotation process, theindividual electromagnet 3 corresponding to theanalysis container 5 that needs to provide a magnetic field to be cleaned will constantly change, and the effect of the electromagnetic field and theanalysis container 5 being relatively synchronized is achieved by switching the power supply of theelectromagnet 3 individual, so as to ensure its Adsorption effect.

值得注意的是，图1为示意图，第二圆盘2中的电磁体3的数量可以根据磁场同步精度的不同要求进行增减。对应不同的机械设计方案，第二圆盘2与第一圆盘1的作用可能互换，相应的会引起电磁体3和分析容器5位置的变化。It should be noted that FIG. 1 is a schematic diagram, and the number ofelectromagnets 3 in thesecond disk 2 can be increased or decreased according to different requirements of magnetic field synchronization accuracy. Corresponding to different mechanical design schemes, the functions of thesecond disk 2 and the first disk 1 may be interchanged, correspondingly causing changes in the positions of theelectromagnet 3 and theanalysis container 5 .

尽管本发明的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用，它完全可以被适用于各种适合本发明的领域，对于熟悉本领域的人员而言，可容易地实现另外的修改，因此在不背离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节和这里示出与描述的图例。Although the embodiment of the present invention has been disclosed as above, it is not limited to the use listed in the specification and implementation, it can be applied to various fields suitable for the present invention, and it can be easily understood by those skilled in the art Therefore, the invention is not limited to the specific details and examples shown and described herein without departing from the general concept defined by the claims and their equivalents.

Claims (9)

1. the cleaning device in Full-automatic chemiluminescence immunoassay analysis meter, is characterized in that, comprising:

The first disk, it is by driving mechanism driven rotary, and the peripheral part of described the first disk is provided with spaced multiple analyzing container, throws in the magnetic microsphere that is useful on absorption body fluid sample to be detected in analyzing container;

The second disk, it is arranged on the top of described the first disk coaxially, and the diameter of described the second disk is less than the diameter of described the first disk, and the peripheral part of described the second disk is provided with spaced multiple electromagnet;

Cleaning part, it is arranged on a side of described the first disk, and relative with at least one in multiple electromagnets of described the second disk;

Wherein, the first disk rotates, to drive the analyzing container on the first disk optionally to rest on cleaning part place.

2. the cleaning device in Full-automatic chemiluminescence immunoassay analysis meter as claimed in claim 1, it is characterized in that, described driving mechanism adopts synchronous belt drive mechanism, it comprises motor, Timing Belt, synchronous pulley, the outer of described the first disk is provided with the tooth engaging with described Timing Belt, the output terminal of described motor connects described synchronous pulley, described synchronous pulley is connected with the tooth of described the first disk by described Timing Belt, and described motor is optionally rotated or stopped by the first disk described in Timing Belt control.

3. the cleaning device in Full-automatic chemiluminescence immunoassay analysis meter as claimed in claim 1 or 2, is characterized in that, described multiple analyzing containers interval each other equates with described multiple electromagnets interval each other.

4. the cleaning device in Full-automatic chemiluminescence immunoassay analysis meter as claimed in claim 3, is characterized in that, described cleaning part comprises:

Bracing frame, comprises base and footstock, and described footstock is provided with lifting table;

Aspirating needle, it is arranged on described lifting table, and vertically extends downwards by described lifting table;

Fluid injection pin, itself and described aspirating needle are arranged side by side on described lifting table, and extend downwards by described lifting table, and described fluid injection pin tilts towards described electromagnet direction;

Soda liquor container, itself and described fluid injection pin pass through pipeline connection, and on pipeline, are provided with liquid pump;

Delivery pipe, it is communicated with described aspirating needle, and is provided with liquid pump on pipeline.

5. the cleaning device in Full-automatic chemiluminescence immunoassay analysis meter as claimed in claim 4, is characterized in that, described analyzing container is upper opening cylinder tank, and when analyzing container rests on cleaning part place, aspirating needle, fluid injection pin are relative with a tank opening.

6. the cleaning device in Full-automatic chemiluminescence immunoassay analysis meter as claimed in claim 5, is characterized in that, the whole peripheral part of described the second disk is provided with spaced multiple electromagnet, and described cleaning device also comprises:

Controller, controls separately the power on/off of each electromagnet.

7. the cleaning device in Full-automatic chemiluminescence immunoassay analysis meter as claimed in claim 6, it is characterized in that, when described controller control liquid pump, make in adsorption process and during aspirating needle imbibition, the electromagnet energising corresponding with analyzing container to be cleaned, and when described controller control liquid pump, while making the fluid injection of fluid injection pin, the electromagnet power-off corresponding with analyzing container to be cleaned.

8. the cleaning device in Full-automatic chemiluminescence immunoassay analysis meter as claimed in claim 7, is characterized in that, also comprises:

Timer, it calculates the reaction time of each analyzing container, and described timer is connected with described controller communication, and the reaction time of the analyzing container receiving when controller exceedes setting value, and the reaction being judged to be in this analyzing container finishes;

Steady arm, it is positioned in the process of the first dial rotation, the residing position of each analyzing container;

If controller judges the reaction in an analyzing container, finish, according to the location of steady arm, start its relative electromagnet energising; If carrying out and controller judges the reaction in an analyzing container, according to the location of steady arm, making its relative electromagnet power-off.

9. the cleaning device in Full-automatic chemiluminescence immunoassay analysis meter as claimed in claim 8, is characterized in that, described magnetic microsphere is nano-scale magnetic microballoon.

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