技术领域technical field
本发明涉及烟草领域，具体地涉及一种清咽润喉型烟草口腔喷剂及其制备方法。The invention relates to the field of tobacco, in particular to a throat-clearing and throat-moistening tobacco mouth spray and a preparation method thereof.
背景技术Background technique
目前市场上流通的传统卷烟燃烧后会产生气相和粒相两部分的气溶胶。气相部分约占整个烟气质量的92%，粒相部分约占8%。这两部分气溶胶中的一些成分会污染环境，此外，吸烟后的烟蒂也存在引发火灾的可能。The traditional cigarettes currently on the market will produce aerosols in two parts, gas phase and particle phase, after burning. The gas phase part accounts for about 92% of the whole flue gas mass, and the particle phase part accounts for about 8%. Some components in these two parts of the aerosol can pollute the environment. In addition, the cigarette butts after smoking may also cause fires.
随着国际控烟运动的脚步愈发加快，各国政府对吸烟尤其是对公共场所吸烟的限制愈加严格，并逐渐形成了社会共识。在日趋严格的控烟环境下，部分烟草消费者可能会选择新的非传统烟草制品，并且这种变化趋势日渐清晰。据2011年统计数据显示，在世界范围内卷烟产销量有所下降的同时，其他类型烟草制品呈现快速增长趋势。据估算，2011年世界非传统烟草制品市场销售总值约为600亿美元，其中无烟气烟草制品约为160亿美元，成为世界烟草市场上的一股新兴势力。因此，进一步研究开发出新型无烟气烟草显得尤为必要。As the pace of the international tobacco control movement is accelerating, governments around the world are increasingly restricting smoking, especially smoking in public places, and a social consensus has gradually formed. Under the increasingly stringent tobacco control environment, some tobacco consumers may choose new non-traditional tobacco products, and this trend of change is becoming clearer. According to statistics in 2011, while the production and sales of cigarettes worldwide have declined, other types of tobacco products have shown a trend of rapid growth. It is estimated that in 2011, the total sales value of the world's non-traditional tobacco products market was about 60 billion US dollars, of which smokeless tobacco products were about 16 billion US dollars, becoming an emerging force in the world tobacco market. Therefore, it is particularly necessary to further research and develop a new type of smokeless tobacco.
吸烟、饮酒等不良生活习惯，以及经常暴露在不卫生的空气环境中会使人容易患急慢性咽喉炎和咽喉不适等常见症状，临床上经常使用消炎药和中成药治疗，同时也需要采取一定的预防和保健措施。中医药是中华民族的宝贵财富，在保健养身、疾病防控方面发挥着非常重要的作用。Smoking, drinking and other bad living habits, as well as frequent exposure to unhygienic air environment will make people prone to common symptoms such as acute and chronic pharyngitis and throat discomfort. Clinically, anti-inflammatory drugs and Chinese patent medicines are often used for treatment. preventive and healthcare measures. Traditional Chinese medicine is the precious wealth of the Chinese nation and plays a very important role in health care and disease prevention and control.
发明内容Contents of the invention
本发明要解决的第一个技术问题是提供一种清咽润喉型烟草口腔喷剂，包括以下物质，按质量分数计为：5-30%烟草提取物；0.14-4.2%中草药提取物；1-10%烟用香精；其余为辅助材料；其中，所述中药提取物为甘草、胖大海、桔梗、金银花、野菊花、黄芪和丁香的提取物；该喷剂既能提供使用者等同于吸食传统卷烟的满足感还具有清咽润喉的第二功效。The first technical problem to be solved by the present invention is to provide a throat-clearing and throat-relieving tobacco mouth spray, which comprises the following substances, calculated by mass fraction: 5-30% tobacco extract; 0.14-4.2% Chinese herbal medicine extract; 1-10% tobacco essence; the rest are auxiliary materials; wherein, the Chinese medicine extracts are extracts of licorice, sterculia, bellflower, honeysuckle, wild chrysanthemum, astragalus and clove; the spray can provide users with the same The satisfaction of smoking traditional cigarettes also has a secondary effect of clearing and moisturizing the throat.
本发明要解决的第二个技术问题是提供一种清咽润喉型烟草口腔喷剂的制备方法。The second technical problem to be solved by the present invention is to provide a preparation method of a throat-clearing and throat-moistening tobacco oral spray.
本发明采用下述技术方案：The present invention adopts following technical scheme:
一种清咽润喉型烟草口腔喷剂，包括以下物质，按质量分数计为：5-30%烟草提取物；0.14-4.2%中草药提取物；1-10%烟用香精；其余为辅助材料；其中，所述中药提取物为甘草、胖大海、桔梗、金银花、野菊花、黄芪和丁香的提取物。A throat-clearing and throat-releasing tobacco oral spray, comprising the following substances, calculated by mass fraction: 5-30% tobacco extract; 0.14-4.2% Chinese herbal medicine extract; 1-10% tobacco essence; the rest are auxiliary materials ; Wherein, the Chinese medicine extract is the extract of licorice, Panda Dahai, platycodon grandiflorum, honeysuckle, wild chrysanthemum, astragalus and clove.
优选地，所述中草药提取物为：0.02-0.6%甘草提取物、0.02-0.6%胖大海提取物、0.02-0.6%桔梗提取物、0.02-0.6%金银花提取物、0.02-0.6%野菊花提取物、0.02-0.6%黄芪提取物和0.02-0.6%丁香提取物。Preferably, the Chinese herbal medicine extracts are: 0.02-0.6% licorice extract, 0.02-0.6% fat sea extract, 0.02-0.6% bellflower extract, 0.02-0.6% honeysuckle extract, 0.02-0.6% wild chrysanthemum extract extract, 0.02-0.6% astragalus extract and 0.02-0.6% clove extract.
优选地，所述烟草口腔喷剂的pH值为7～9；更优选地，所述烟草口腔喷剂的pH值为9。烟碱为烟草提取物中主要活性成分之一，烟碱从口腔吸收进入人体循环取决于唾液、血浆的pH和烟碱的酸碱平衡。烟碱的酸碱平衡在37℃下为约pH为7.8。假设唾液的pH为6.8，则仅约10%的烟碱将会为不带电的碱形式。因此，为了促进烟碱以游离碱形式（其为主要通过粘膜吸收的形式）吸收，必须增加唾液的pH。在pH为9.0时，多于90%的烟碱将会是容易吸收的游离碱形式。Preferably, the pH value of the tobacco oral spray is 7-9; more preferably, the pH value of the tobacco oral spray is 9. Nicotine is one of the main active ingredients in tobacco extract, and the absorption of nicotine from the oral cavity into the human circulation depends on the pH of saliva, plasma and the acid-base balance of nicotine. The acid-base balance of nicotine is about pH 7.8 at 37°C. Assuming a pH of 6.8 in saliva, only about 10% of the nicotine will be in the uncharged base form. Therefore, in order to promote the absorption of nicotine in the free base form, which is the form absorbed mainly through the mucous membranes, the pH of saliva must be increased. At a pH of 9.0, more than 90% of the nicotine will be in the readily absorbed free base form.
所述烟草提取物即为从烟叶中提取的烟草有效活性成分，指烟草中含有的以醇、醛、酮、酯、烃类、杂环类为主的烟草香味物质（苯甲醇、植醇、西伯三烯二醇、3-甲基-2-丁烯醛、苯甲醛、茄酮、巨豆三烯酮、二氢猕猴桃内酯、棕榈酸甲酯、棕榈酸乙酯、新植二烯、吡啶等）以及其它生物活性物质，如生物碱、茄尼醇、蛋白质、氨基酸和糖类等。The tobacco extract is the effective active ingredient of tobacco extracted from tobacco leaves, and refers to the tobacco aroma substances (benzyl alcohol, phytol, Cibrantrienediol, 3-methyl-2-butenal, benzaldehyde, solanone, macrostigmatrienone, dihydroactinolactone, methyl palmitate, ethyl palmitate, neophytadiene, pyridine, etc.) and other biologically active substances, such as alkaloids, solanesol, proteins, amino acids, and sugars.
优选地，所述烟草提取物是烤烟提取物、晾烟提取物、晒烟提取物中的一种或两种以上混合物；所述晾烟为白肋烟、马里兰烟、雪茄包叶烟；所述晒烟为香料烟、晒红烟、晒黄烟、黄花烟；烟叶中烟碱的含量为2.2～2.3%。Preferably, the tobacco extract is one or more mixtures of flue-cured tobacco extract, air-cured tobacco extract, and sun-cured tobacco extract; the air-cured tobacco is Burley tobacco, Maryland tobacco, and cigar wrapper tobacco; the The sun-cured tobacco includes oriental tobacco, red sun-cured tobacco, yellow sun-cured tobacco, and yellow flower tobacco; the content of nicotine in the tobacco leaves is 2.2-2.3%.
优选地，所述烟草提取物是通过以下步骤获得的：1）烟草提取液的制备：通过复配原料，保证原料烟叶中烟碱含量在2.2～2.3%，准确称取烟叶粉末样品，加入75-80%乙醇回流提取，固液比为1：10～15，回流提取1～2h后过滤并取其滤液，55～65℃下水浴浓缩滤液，得到烟草提取液；2）通过制备型高速逆流色谱仪设定不同溶剂体系对烟草提取液进行分离；3）确定馏分出峰时间；4）分段收集有效活性成分，得到烟草提取物。Preferably, the tobacco extract is obtained through the following steps: 1) Preparation of tobacco extract: by compounding raw materials to ensure that the nicotine content in raw tobacco leaves is 2.2-2.3%, accurately weigh tobacco leaf powder samples, add 75 -80% ethanol reflux extraction, the solid-liquid ratio is 1:10~15, reflux extraction for 1~2h, filter and take the filtrate, and concentrate the filtrate in a water bath at 55~65°C to obtain tobacco extract; 2) Through the preparative high-speed countercurrent The chromatograph sets different solvent systems to separate the tobacco extract; 3) Determine the peak eluting time of the fraction; 4) Collect the effective active ingredients in sections to obtain the tobacco extract.
高速逆流色谱仪是可用于烟草中生物碱类化合物、黄酮类化合物、萜类化合物、有机酸类化合物、木质素和香豆素类化合物、醌类化合物的分离与提取的仪器。High-speed countercurrent chromatography is an instrument that can be used for the separation and extraction of alkaloids, flavonoids, terpenoids, organic acids, lignin, coumarin, and quinones in tobacco.
中草药提取物中的活性成分，以甘草为例，甘草最主要的活性成分就是甘草酸，甘草酸又称甘草甜素，是一种三萜衍生物，为甘草次酸的二葡萄糖醛苷，是甘草的甜味成份，存在于甘草属植物中，具有抗炎、抗病毒、保肝解毒和增强免疫功能等作用。Active ingredients in Chinese herbal medicine extracts, taking licorice as an example, the main active ingredient of licorice is glycyrrhizic acid, glycyrrhizic acid, also known as glycyrrhizin, is a triterpene derivative, diglucuronide of glycyrrhetinic acid, is The sweet component of licorice, which exists in the licorice genus, has anti-inflammatory, anti-viral, liver-protecting and detoxifying effects, and enhances immune function.
所述中草药提取物可通过市场直接购买获得，也可自行提取。自行提取时，可每个中药分别提取，最后混合，也可一次提取各中药的混合物。The Chinese herbal medicine extract can be purchased directly from the market, or can be extracted by itself. When self-extracting, each traditional Chinese medicine can be extracted separately and finally mixed, or the mixture of each traditional Chinese medicine can be extracted at one time.
本发明中涉及到的中草药均药食同源。The Chinese herbal medicines involved in the present invention all have the same source of medicine and food.
优选地，所述中草药提取物是按照以下步骤提取的：Preferably, the Chinese herbal medicine extract is extracted according to the following steps:
将各中药原料混合均匀，在70℃～75℃纯净水中浸渍，固液比为1：10～15，超声萃取提取1～3h后过滤并取其滤液，滤渣再加入7～9倍剂量的水继续超声提取1～3h过滤并取其滤液，合并两次滤液；将滤液加入旋转蒸发仪中浓缩至滤液体积的1/3～2/3时停止浓缩，冷却浓缩液，得到中草药粗提液；离心中草药粗提液，取上清液，即得中草药提取物。Mix all the raw materials of traditional Chinese medicine evenly, soak in pure water at 70°C~75°C, the solid-liquid ratio is 1:10~15, extract by ultrasonic extraction for 1~3h, filter and take the filtrate, add 7~9 times the dose of water to the filter residue Continue ultrasonic extraction for 1 to 3 hours to filter, take the filtrate, and combine the two filtrates; add the filtrate to a rotary evaporator to concentrate to 1/3 to 2/3 of the volume of the filtrate, stop the concentration, cool the concentrated solution, and obtain the crude extract of Chinese herbal medicine; The crude extract of Chinese herbal medicine is centrifuged, and the supernatant is taken to obtain the Chinese herbal medicine extract.
所述中草药选择干燥、无虫蛀、无霉烂、无异味的中草药，经粉碎机粉碎后提取。The Chinese herbal medicine is selected to be dry, free from insects, mildew and rot, and has no peculiar smell, and is extracted after pulverized by a pulverizer.
本领域技术人员可根据需要选择适合的烟用香精。具体来讲，首先通过顶空蒸馏-GC/MS对不同类型烟草的香味物质进行定性定量分析或者以剑桥滤片收集烤烟主流烟气粒相物，采用GC/MS对主流烟气的香味物质进行定性定量分析，进而初步拟定具有烟草香韵的烟用香精的种类，调整不同物质的添加比例，经过烟香师反复辩香，确定具有烟草香韵的烟用香精的种类和添加比例。优选地，所述烟用香精为β-大马酮、β-二氢大马酮、2,6,6-三甲基-2-环己烯-1,4-二酮、2-羟基-3,5,5-三甲基-2-环己烯酮、香叶基丙酮、β-紫罗兰酮、糠醛、5-甲基糠醛、苯甲醛、苯乙醛、苯甲醇、棕榈酸、异戊酸、2-甲基戊酸、乙酸、苯乙酸、二氢猕猴桃内酯、丁二酸二甲酯、吲哚、吡啶、3-乙酰基吡啶、3-乙基吡啶、2-甲基吡嗪、2,3,5-三甲基吡嗪中的一种或两种以上混合物。Those skilled in the art can select suitable flavoring essence for tobacco according to needs. Specifically, the qualitative and quantitative analysis of the aroma substances of different types of tobacco was carried out by headspace distillation-GC/MS first, or the particulate matter of flue-cured tobacco mainstream smoke was collected by Cambridge filter, and the aroma substances of mainstream smoke were analyzed by GC/MS. Qualitative and quantitative analysis, and then preliminarily draw up the types of tobacco flavors with tobacco flavors, adjust the addition ratio of different substances, and determine the types and addition ratios of tobacco flavors with tobacco flavors after repeated fragrance debates by tobacco flavorists. Preferably, the tobacco flavor is β-damascenone, β-dihydrodamascenone, 2,6,6-trimethyl-2-cyclohexene-1,4-dione, 2-hydroxy- 3,5,5-Trimethyl-2-cyclohexenone, geranylacetone, β-ionone, furfural, 5-methylfurfural, benzaldehyde, phenylacetaldehyde, benzyl alcohol, palmitic acid, isopentyl Acid, 2-methylpentanoic acid, acetic acid, phenylacetic acid, dihydroactinolic acid, dimethyl succinate, indole, pyridine, 3-acetylpyridine, 3-ethylpyridine, 2-methylpyrazine , 2,3,5-trimethylpyrazine or a mixture of two or more.
本领域技术人员可根据需要选择适合的辅助材料。优选地，所述辅助材料包括防腐剂、pH调节剂、甜味剂、溶剂。各种辅助材料之间的用量比无须限定，本领域技术人员可根据实际需要来选择。Those skilled in the art can select suitable auxiliary materials according to needs. Preferably, the auxiliary materials include preservatives, pH regulators, sweeteners, and solvents. There is no need to limit the dosage ratio of various auxiliary materials, and those skilled in the art can choose according to actual needs.
更优选地，所述防腐剂为苯甲酸及其钠盐、丙酸及其钠盐或钙盐、对羟基苯甲酸酯类及其钠盐（对羟基苯甲酸甲酯钠，对羟基苯甲酸乙酯及其钠盐）、山梨酸及其钾盐、焦亚硫酸钾、焦亚硫酸钠、亚硫酸钠、亚硫酸氢钠或低亚硫酸钠。防腐剂的用量按照GB2760-2011≤食品添加剂使用标准≥的规定。More preferably, the preservative is benzoic acid and its sodium salt, propionic acid and its sodium or calcium salt, parabens and its sodium salt (sodium methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate esters and their sodium salts), sorbic acid and its potassium salts, potassium metabisulfite, sodium metabisulfite, sodium sulfite, sodium bisulfite or sodium hyposulfite. The amount of preservatives is in accordance with the provisions of GB2760-2011≤Usage Standards for Food Additives≥.
所述pH调节剂为柠檬酸、山梨酸、苹果酸、碳酸氢钠或磷酸氢二钠。The pH regulator is citric acid, sorbic acid, malic acid, sodium bicarbonate or disodium hydrogen phosphate.
所述甜味剂为一种或多种合成的糖或天然糖，即适合用作甜味剂的任何形式的糖类。The sweetener is one or more synthetic or natural sugars, ie any form of sugar suitable for use as a sweetener.
所述溶剂为纯净水或者纯净水和食用甘油的混合物。The solvent is purified water or a mixture of purified water and edible glycerin.
添加食用甘油是为了溶解一些不/难溶于水的烟用香精，譬如β-大马酮、β-二氢大马酮、2,6,6-三甲基-2-环己烯-1,4-二酮、香叶基丙酮、苯甲醛、苯乙醛、棕榈酸、二氢猕猴桃内酯。食用甘油的量满足溶解烟用香精即可。Edible glycerin is added to dissolve some tobacco flavors that are not/poorly soluble in water, such as β-damascone, β-dihydrodamascone, 2,6,6-trimethyl-2-cyclohexene-1 ,4-Diketone, Geranylacetone, Benzaldehyde, Phenylacetaldehyde, Palmitic Acid, Dihydroactinolactone. The amount of edible glycerin is enough to dissolve the tobacco essence.
本发明的喷剂可采用20g、50g、100g等等各种剂量规格包装。The spray of the present invention can be packaged in various dosage specifications such as 20g, 50g, 100g, etc.
一种清咽润喉型烟草口腔喷剂的制备方法，包括以下步骤：A preparation method of throat-clearing and throat-moistening tobacco mouth spray, comprising the following steps:
1）将黄甘草提取物、胖大海提取物、桔梗提取物、金银花提取物、野菊花提取物、黄芪提取物和丁香提取物溶解，得混合溶液A，备用；1) Dissolve yellow licorice extract, fat sea extract, bellflower extract, honeysuckle extract, wild chrysanthemum extract, astragalus extract and clove extract to obtain mixed solution A, set aside;
2）将烟用香精溶解，得混合溶液B，备用；2) Dissolve the tobacco essence to obtain a mixed solution B for later use;
3）将混合溶液A和混合溶液B合并，向其中加入烟草提取物、辅助材料，搅拌均匀，调节pH至适宜pH值，然后灌装在喷剂瓶内，制成成品。3) Combine mixed solution A and mixed solution B, add tobacco extract and auxiliary materials to it, stir evenly, adjust the pH to an appropriate pH value, and then fill it in a spray bottle to make a finished product.
一种清咽润喉型烟草口腔喷剂的制备方法，包括以下步骤：A preparation method of throat-clearing and throat-moistening tobacco mouth spray, comprising the following steps:
1）将甘草、胖大海、桔梗、金银花、野菊花、黄芪和丁香七味中草药的提取物混合均匀，加入纯净水溶解，得混合溶液A，备用；1) Mix the extracts of licorice, fat sea, bellflower, honeysuckle, wild chrysanthemum, astragalus and clove seven Chinese herbal medicines evenly, add pure water to dissolve, and get mixed solution A, set aside;
2）将烟用香精，加入适量食用甘油溶解，得混合溶液B，备用；2) Dissolve the tobacco essence by adding an appropriate amount of edible glycerin to obtain a mixed solution B for later use;
3）将混合溶液A和准确质量的混合溶液B合并，向其中加入烟草提取物、其他辅助材料，纯净水定量，搅拌均匀，将制品用pH调节剂调节至适宜pH值，然后灌装在喷剂瓶内，制成成品。3) Combine mixed solution A and mixed solution B with accurate mass, add tobacco extract and other auxiliary materials to it, quantify purified water, stir evenly, adjust the product to a suitable pH value with a pH regulator, and then fill it in the spray In the bottle, it is made into a finished product.
本发明的有益效果如下：The beneficial effects of the present invention are as follows:
1、本发明的喷剂环保、无烟气，除了能提供使用者等同于吸食传统卷烟的满足感外还具有清咽润喉的第二功效。1. The spray of the present invention is environmentally friendly and has no smoke, and besides providing the user with a sense of satisfaction equivalent to that of smoking traditional cigarettes, it also has the second effect of clearing and moistening the throat.
2、烟草消费者经常使用本发明这种不以治疗疾病为目的的清咽润喉口腔喷剂可起到保健作用，使用者采用不会有医药联想而是与生活相关的手段就能享受到制品中中草药成分的清咽润喉功效；目前国内外尚未见到此类清咽润喉型烟草口腔喷剂配方的报道，本发明具有广阔的应用前景。2. Tobacco consumers often use the throat-clearing and throat-moistening oral spray of the present invention for the purpose of not treating diseases, which can play a role in health care, and users can enjoy it by using means that do not have medical associations but are related to life. Throat-clearing and throat-moistening effect of Chinese herbal medicine components in the product; at present, no report of this type of throat-clearing and throat-moistening tobacco oral spray formula has been seen at home and abroad, and the present invention has broad application prospects.
3、本发明的制剂既能使使用者得到等同于吸食传统卷烟的满足感，又能享受到中草药活性成分的清咽润喉功效，还可以避免传统卷烟燃烧对环境的影响以及二手烟对非吸烟人群和烟草消费者自身的危害，它的研发及制造技术研究对加快烟草科技进步、提升卷烟品牌价值和应对新的控烟形势具有重要的现实意义。3. The preparation of the present invention can not only enable users to obtain the satisfaction equivalent to smoking traditional cigarettes, but also enjoy the throat-clearing and throat-clearing effect of the active ingredients of Chinese herbal medicines, and can also avoid the impact of traditional cigarette burning on the environment and the impact of second-hand smoke on non- The harm of smokers and tobacco consumers themselves, its research and development and manufacturing technology research have important practical significance for accelerating the progress of tobacco technology, enhancing the value of cigarette brands and responding to the new situation of tobacco control.
4、本发明既适用于男性、也适用于女性，使用者采用不会有医药联想而是与生活相关的手段就能享受到配方中中草药成分的清咽润喉功效。4. The present invention is suitable for both males and females. Users can enjoy the throat-clearing and throat-moistening effect of the Chinese herbal ingredients in the formula by using means that do not have medical associations but are related to life.
5、添加烟用香精能提供卷烟消费者嗅觉、味觉满足感。5. Adding tobacco flavor can provide cigarette consumers with sense of smell and taste satisfaction.
6、本发明配伍合理，易于制造，喷剂式的制品携带方便，使用卫生，本发明的喷剂制品既可以作为禁烟场所传统卷烟的临时替代品，也可以成为吸烟者日常生活中一种理想的新型环保功能型无烟气烟草制品。6. The invention has reasonable compatibility, is easy to manufacture, and the spray product is easy to carry and hygienic to use. The spray product of the present invention can be used as a temporary substitute for traditional cigarettes in places where smoking is prohibited, and can also be an ideal smoker’s daily life. A new environmentally friendly functional smokeless tobacco product.
具体实施方式detailed description
为了更清楚地说明本发明，下面结合优选实施例对本发明做进一步的说明。本领域技术人员应当理解，下面所具体描述的内容是说明性的而非限制性的，不应以此限制本发明的保护范围。In order to illustrate the present invention more clearly, the present invention will be further described below in conjunction with preferred embodiments. Those skilled in the art should understand that the content specifically described below is illustrative rather than restrictive, and should not limit the protection scope of the present invention.
甘草性平，味甘，归十二经，甜度是蔗糖的百倍，是一种补益中草药，能清热解毒，利咽润喉、润肺止咳，补脾益气，调和诸药性。Licorice is flat in nature, sweet in taste, belongs to the twelve meridians, and its sweetness is 100 times that of sucrose. It is a kind of tonic Chinese herbal medicine, which can clear away heat and detoxify, relieve throat and moisten throat, moisten lung and relieve cough, invigorate spleen and Qi, and reconcile the properties of various medicines.
胖大海性质寒凉，作用于肺经，善于清利咽喉热毒，并能清泻肺热，十分适用于治疗咽喉肿痛。Panda Dahai is cold and cool in nature, acts on the lung meridian, is good at clearing heat and toxins in the throat, and can clear away lung heat, so it is very suitable for treating sore throat.
桔梗，其功效为开宣肺气，祛痰排脓。可治外感咳嗽，咽喉肿痛，肺痈吐脓，胸满胁痛，痢疾腹痛。Platycodon grandiflorum, its effect is to open lung qi, expel phlegm and discharge pus. It can cure cough due to exogenous pathogenic factors, sore throat, lung abscess and vomiting of pus, chest fullness and hypochondriac pain, dysentery and abdominal pain.
金银花性甘寒气芳香，甘寒清热而不伤胃，芳香透达又可祛邪。它既能宣散风热，还善清解血毒，可用于各种热性病，如身热、发疹、发斑、热毒疮痈、咽喉肿痛等症，均效果显著。Honeysuckle is sweet and cold in nature and fragrant in nature. It is sweet and cold in clearing away heat without hurting the stomach. The fragrance is thorough and can dispel pathogens. It can dispel wind-heat, clear blood and detoxify, and can be used for various febrile diseases, such as body heat, rash, spots, heat-toxin sores, sore throat, etc., and the effect is remarkable.
野菊花清热解毒，消肿，对金黄色葡萄球菌、白喉杆菌、链球菌、绿脓杆菌、蒺疾杆菌、流感病毒，均有抑制作用。可广泛用于治疗疔疮痈肿、咽喉肿痛、风火赤眼、头痛眩晕等病症。Wild chrysanthemum clears heat, detoxifies, reduces swelling, and has inhibitory effects on Staphylococcus aureus, diphtheria bacillus, streptococcus, Pseudomonas aeruginosa, Bacillus terrestris, and influenza virus. It can be widely used in the treatment of furuncle carbuncle, sore throat, red eyes due to wind-fire, headache, dizziness and other diseases.
黄芪有清热燥湿，解毒功效。主治温热病、上呼吸道感染、肺热咳嗽、湿热黄胆、肺炎、痢疾、咳血、目赤、高血压、痈肿疖疮等症。Astragalus has heat-clearing, damp-drying and detoxifying effects. Indications for febrile disease, upper respiratory tract infection, lung-heat cough, damp-heat jaundice, pneumonia, dysentery, hemoptysis, red eyes, high blood pressure, carbuncle, swollen boils and other diseases.
实施例1Example 1
制备20g喷剂制品：Preparation of 20g spray preparation:
（1）将甘草、胖大海、桔梗、金银花、野菊花、黄芪和丁香七味中草药提取物混合均匀后加入10g纯净水溶解，得混合溶液A，备用；(1) Mix the Chinese herbal medicine extracts of licorice, fat sea, bellflower, honeysuckle, wild chrysanthemum, astragalus and clove, and then add 10g of pure water to dissolve to obtain a mixed solution A, which is set aside;
（2）将按以上比例称取的烟用香精混合均匀，加入适量食用甘油溶解，得混合溶液B，备用（使用时再根据要求称取准确质量）；(2) Mix the tobacco flavors weighed according to the above proportions evenly, add an appropriate amount of edible glycerin to dissolve, and obtain a mixed solution B for use (weigh the accurate mass according to the requirements when using);
（3）将混合溶液A和准确质量的混合溶液B合并，向其中加入烟草提取物、尼泊尔乙酯、蔗糖，纯净水定量到20g，搅拌均匀，用pH调节剂将制品调节至适宜pH值，然后灌装在喷剂瓶内，制成成品。(3) Combine the mixed solution A and the mixed solution B with accurate mass, add tobacco extract, ethyl Nepalese ester, sucrose to it, quantify the purified water to 20g, stir evenly, adjust the product to an appropriate pH value with a pH regulator, It is then filled in a spray bottle to make a finished product.
使用效果评价：组织三名烟草评析人员使用该喷剂制品，实验结果表明，当评吸人员产生抽吸卷烟欲望时，一次性喷吸入0.4g该制品，平均2min后抽吸卷烟欲望消失，并且无抽吸卷烟欲望可平均持续69min。Evaluation of use effect: Organize three tobacco reviewers to use this spray product. The experimental results show that when the reviewers have the desire to smoke cigarettes, they spray 0.4g of this product at one time, and the desire to smoke cigarettes disappears after an average of 2 minutes, and The mean duration of no desire to smoke cigarettes was 69 minutes.
实施例2Example 2
制备50g喷剂制品：Preparation of 50g spray preparation:
（1）将甘草、胖大海、桔梗、金银花、野菊花、黄芪和丁香七味中草药提取物混合均匀后加入30g纯净水溶解，得混合溶液A，备用；(1) Mix licorice, fat sea, bellflower, honeysuckle, wild chrysanthemum, astragalus and clove seven Chinese herbal medicine extracts, add 30g of pure water to dissolve, get mixed solution A, set aside;
（2）将烟用香精和柠檬香香味物质混合均匀，加入适量食用甘油溶解，得混合溶液B，备用（使用时再根据要求称取准确质量）；(2) Mix the tobacco essence and the lemon aroma substance evenly, add an appropriate amount of edible glycerin to dissolve, and obtain the mixed solution B, and set it aside (weigh the accurate mass according to the requirements when using);
（3）将混合溶液A和准确质量的混合溶液B合并，向其中加入烟草提取物、山梨酸、蔗糖，纯净水定量到50g，搅拌均匀，用pH调节剂将制品调节至适宜pH值，然后灌装在喷剂瓶内，制成成品。(3) Combine mixed solution A and mixed solution B with accurate mass, add tobacco extract, sorbic acid, sucrose to it, quantify purified water to 50g, stir evenly, adjust the product to an appropriate pH value with a pH regulator, and then Filled in a spray bottle to make a finished product.
使用效果评价：组织三名烟草评析人员使用该喷剂制品，实验结果表明，当评吸人员产生抽吸卷烟欲望时，一次性喷吸入0.4g该制品，平均2min后抽吸卷烟欲望消失，并且无抽吸卷烟欲望可平均持续60min。Evaluation of use effect: Organize three tobacco reviewers to use this spray product. The experimental results show that when the reviewers have the desire to smoke cigarettes, they spray 0.4g of this product at one time, and the desire to smoke cigarettes disappears after an average of 2 minutes, and The desire to not smoke cigarettes lasted an average of 60 minutes.
实施例3Example 3
制备100g喷剂制品：Preparation of 100g spray product:
（1）将甘草、胖大海、桔梗、金银花、野菊花、黄芪和丁香七味中草药提取物混合均匀后加入65g纯净水溶解，得混合溶液A，备用；(1) Mix the Chinese herbal medicine extracts of licorice, fat sea, bellflower, honeysuckle, wild chrysanthemum, astragalus and clove, and then add 65g of pure water to dissolve to obtain a mixed solution A, which is set aside;
（2）将烟用香精和水蜜桃香味物质混合均匀，加入适量食用甘油溶解，得混合溶液B，备用（使用时再根据要求称取准确质量）；(2) Mix the tobacco essence and the peach aroma substance evenly, add an appropriate amount of edible glycerin to dissolve, and obtain the mixed solution B, and set it aside (weigh the accurate mass according to the requirements when using);
（3）将混合溶液A和准确质量的混合溶液B合并，向其中加入烟草提取物、尼泊尔乙酯、蔗糖，纯净水定量到100g，搅拌均匀，用pH调节剂将制品调节至适宜pH值，然后灌装在喷剂瓶内，制成成品。(3) Combine mixed solution A and mixed solution B with accurate mass, add tobacco extract, ethyl Nepalese ester, sucrose to it, quantify purified water to 100g, stir evenly, adjust the product to an appropriate pH value with a pH regulator, It is then filled in a spray bottle to make a finished product.
使用效果评价：组织三名烟草评析人员使用该喷剂制品，实验结果表明，当评吸人员产生抽吸卷烟欲望时，一次性喷吸入0.4g该制品，平均2min后抽吸卷烟欲望消失，并且无抽吸卷烟欲望可平均持续52min。Evaluation of use effect: Organize three tobacco reviewers to use this spray product. The experimental results show that when the reviewers have the desire to smoke cigarettes, they spray 0.4g of this product at one time, and the desire to smoke cigarettes disappears after an average of 2 minutes, and The mean duration of no desire to smoke cigarettes was 52 minutes.
实施例4Example 4
一种清咽润喉型烟草口腔喷剂，包括以下物质，按质量分数计为：5%烟草提取物；0.14%中草药提取物；1%烟用香精；其余为辅助材料；其中，所述中药提取物为甘草、胖大海、桔梗、金银花、野菊花、黄芪和丁香的提取物。A throat-clearing and throat-relieving tobacco oral spray, comprising the following substances, calculated by mass fraction: 5% tobacco extract; 0.14% Chinese herbal medicine extract; 1% tobacco essence; the rest are auxiliary materials; wherein, the traditional Chinese medicine The extracts are extracts of licorice, sterculia, bellflower, honeysuckle, wild chrysanthemum, astragalus and clove.
所述烟草提取物是烤烟的提取物，是通过以下步骤获得的：1）烟草提取液的制备：烤烟中烟碱含量在2.2～2.3%，准确称取烟叶粉末样品，加入75%乙醇回流提取，固液比为1：10，回流提取1h后过滤并取其滤液，55℃下水浴浓缩滤液，得到烟草提取液；2）通过制备型高速逆流色谱仪设定不同溶剂体系对烟草提取液进行分离；3）确定馏分出峰时间；4）分段收集有效活性成分，得到烟草提取物。The tobacco extract is an extract of flue-cured tobacco, which is obtained through the following steps: 1) Preparation of tobacco extract: the nicotine content in flue-cured tobacco is 2.2-2.3%, and the tobacco leaf powder sample is accurately weighed, and 75% ethanol is added for reflux extraction , the solid-to-liquid ratio is 1:10, reflux extraction for 1 hour, filter and take the filtrate, and concentrate the filtrate in a water bath at 55°C to obtain the tobacco extract; Separation; 3) Determining the peak eluting time of the fraction; 4) Collecting effective active ingredients in sections to obtain tobacco extract.
所述中草药提取物是按照以下步骤提取的：将各中药原料混合均匀，在70℃纯净水中浸渍，固液比为1：10，超声萃取提取1h后过滤并取其滤液，滤渣再加入7倍剂量的水继续超声提取1h过滤并取其滤液，合并两次滤液；将滤液加入旋转蒸发仪中浓缩至滤液体积的1/3时停止浓缩，冷却浓缩液，得到中草药粗提液；离心中草药粗提液，取上清液，即得中草药提取物。The Chinese herbal medicine extract is extracted according to the following steps: mix each Chinese medicine raw material evenly, soak in pure water at 70°C, the solid-to-liquid ratio is 1:10, extract by ultrasonic extraction for 1 hour, filter and take the filtrate, and add 7 times of the filter residue Dosage of water continued to be ultrasonically extracted for 1 hour and filtered, and the filtrate was taken, and the two filtrates were combined; the filtrate was added to a rotary evaporator to concentrate to 1/3 of the volume of the filtrate, and the concentration was stopped, and the concentrated solution was cooled to obtain the crude extract of Chinese herbal medicine; the crude Chinese herbal medicine was centrifuged Extract the solution and take the supernatant to obtain the Chinese herbal medicine extract.
所述烟用香精为β-大马酮、β-二氢大马酮、2,6,6-三甲基-2-环己烯-1,4-二酮、2-羟基-3,5,5-三甲基-2-环己烯酮、香叶基丙酮、β-紫罗兰酮、糠醛、5-甲基糠醛的混合物（质量比1：2.5：0.5：2：2：3：1.5：2）。The tobacco essence is β-damascenone, β-dihydrodamascenone, 2,6,6-trimethyl-2-cyclohexene-1,4-dione, 2-hydroxyl-3,5 , a mixture of 5-trimethyl-2-cyclohexenone, geranylacetone, β-ionone, furfural, and 5-methylfurfural (mass ratio 1:2.5:0.5:2:2:3:1.5: 2).
所述辅助材料包括防腐剂苯甲酸钠、pH调节剂柠檬酸、甜味剂、溶剂（水和食用甘油的混合物）。The auxiliary materials include preservative sodium benzoate, pH regulator citric acid, sweetener, solvent (mixture of water and edible glycerin).
实施例5Example 5
一种清咽润喉型烟草口腔喷剂，包括以下物质，按质量分数计为：5%烟草提取物；0.6%甘草提取物、0.6%胖大海提取物、0.6%桔梗提取物、0.6%金银花提取物、0.6%野菊花提取物、0.6%黄芪提取物、0.6%丁香提取物；3%烟用香精；其余为辅助材料。所述烟草口腔喷剂的pH值为7。A throat-clearing tobacco oral spray, comprising the following substances, calculated by mass fraction: 5% tobacco extract; 0.6% licorice extract, 0.6% fat sea extract, 0.6% bellflower extract, 0.6% honeysuckle Extract, 0.6% wild chrysanthemum extract, 0.6% astragalus extract, 0.6% clove extract; 3% tobacco flavor; the rest are auxiliary materials. The pH value of the tobacco mouth spray is 7.
所述烟草提取物是白肋烟、马里兰烟和雪茄包叶烟的提取物，是通过以下步骤获得的：1）烟草提取液的制备：通过复配原料，保证烟叶中烟碱含量在2.2～2.3%，准确称取烟叶粉末样品，加入75-80%乙醇回流提取，固液比为1：10～15，回流提取1～2h后过滤并取其滤液，55～65℃下水浴浓缩滤液，得到烟草提取液；2）通过制备型高速逆流色谱仪设定不同溶剂体系对烟草提取液进行分离；3）确定馏分出峰时间；4）分段收集有效活性成分，得到烟草提取物。The tobacco extract is the extract of Burley tobacco, Maryland tobacco and cigar wrapper tobacco, and is obtained through the following steps: 1) Preparation of tobacco extract: by compounding raw materials, the nicotine content in the tobacco leaves is guaranteed to be between 2.2 and 2.3%, accurately weigh the tobacco leaf powder sample, add 75-80% ethanol for reflux extraction, the solid-liquid ratio is 1:10-15, reflux extraction for 1-2 hours, filter and take the filtrate, concentrate the filtrate in a water bath at 55-65 °C, Tobacco extract is obtained; 2) Different solvent systems are set to separate the tobacco extract by a preparative high-speed countercurrent chromatograph; 3) The peak eluting time of fractions is determined; 4) Effective active ingredients are collected in sections to obtain tobacco extract.
所述中草药提取物是按照以下步骤提取的：将各中药原料混合均匀，在75℃纯净水中浸渍，固液比为1：15，超声萃取提取3h后过滤并取其滤液，滤渣再加入9倍剂量的水继续超声提取3h过滤并取其滤液，合并两次滤液；将滤液加入旋转蒸发仪中浓缩至滤液体积的2/3时停止浓缩，冷却浓缩液，得到中草药粗提液；离心中草药粗提液，取上清液，即得中草药提取物。The Chinese herbal medicine extract is extracted according to the following steps: mix the raw materials of Chinese medicine evenly, soak them in pure water at 75°C, the solid-to-liquid ratio is 1:15, extract by ultrasonic extraction for 3 hours, filter and take the filtrate, and add 9 times the filter residue Dosage of water continued to be ultrasonically extracted for 3 hours and filtered, and the filtrate was taken, and the two filtrates were combined; the filtrate was added to a rotary evaporator and concentrated to 2/3 of the volume of the filtrate, and the concentration was stopped, and the concentrated solution was cooled to obtain the crude Chinese herbal medicine extract; the crude Chinese herbal medicine was centrifuged Extract the solution and take the supernatant to obtain the Chinese herbal medicine extract.
所述烟用香精为苯甲醛、苯乙醛、苯甲醇、棕榈酸、异戊酸、2-甲基戊酸、乙酸、苯乙酸、二氢猕猴桃内酯的混合物（质量比1：2.5：0.5：2：2：3：1.5：2：1）。The tobacco flavor is a mixture of benzaldehyde, phenylacetaldehyde, benzyl alcohol, palmitic acid, isovaleric acid, 2-methylpentanoic acid, acetic acid, phenylacetic acid, and dihydroactinolactone (mass ratio 1:2.5:0.5 :2:2:3:1.5:2:1).
所述辅助材料包括防腐剂丙酸、pH调节剂苹果酸、甜味剂、溶剂（水和食用甘油的混合物）。The auxiliary materials include preservative propionic acid, pH regulator malic acid, sweetener, solvent (mixture of water and edible glycerin).
实施例6Example 6
一种清咽润喉型烟草口腔喷剂，包括以下物质，按质量分数计为：30%烟草提取物；0.6%甘草提取物、0.02%胖大海提取物、0.02%桔梗提取物、0.5%金银花提取物、0.6%野菊花提取物、0.02%黄芪提取物、0.02%丁香提取物；10%烟用香精；其余为辅助材料。所述烟草口腔喷剂的pH值为8。A throat-clearing tobacco oral spray, comprising the following substances, calculated by mass fraction: 30% tobacco extract; 0.6% licorice extract, 0.02% fat sea extract, 0.02% bellflower extract, 0.5% honeysuckle extract, 0.6% wild chrysanthemum extract, 0.02% astragalus extract, 0.02% clove extract; 10% tobacco flavor; the rest are auxiliary materials. The pH value of the tobacco oral spray is 8.
所述烟草提取物是香料烟、晒红烟、晒黄烟和黄花烟的提取物，是通过以下步骤获得的：1）烟草提取液的制备：通过复配原料，保证烟叶中烟碱含量在2.2～2.3%，准确称取烟叶粉末样品，加入78%乙醇回流提取，固液比为1：12，回流提取1.5h后过滤并取其滤液，60℃下水浴浓缩滤液，得到烟草提取液；2）通过制备型高速逆流色谱仪设定不同溶剂体系对烟草提取液进行分离；3）确定馏分出峰时间；4）分段收集有效活性成分，得到烟草提取物。The tobacco extract is the extract of oriental tobacco, sun-cured red tobacco, sun-cured yellow tobacco and yellow flower tobacco, and is obtained through the following steps: 1) Preparation of tobacco extract: by compounding raw materials, the nicotine content in tobacco leaves is guaranteed to be 2.2 ～2.3%, accurately weigh the tobacco leaf powder sample, add 78% ethanol for reflux extraction, the solid-liquid ratio is 1:12, reflux extraction for 1.5h, filter and take the filtrate, concentrate the filtrate in a water bath at 60°C, and obtain the tobacco extract; 2 ) Separate the tobacco extract by setting different solvent systems through a preparative high-speed countercurrent chromatograph; 3) Determine the peak eluting time of the fraction; 4) Collect effective active ingredients in sections to obtain tobacco extract.
所述中草药提取物是按照以下步骤提取的：将各中药原料混合均匀，在72℃纯净水中浸渍，固液比为1：12，超声萃取提取2h后过滤并取其滤液，滤渣再加入8倍剂量的水继续超声提取2h过滤并取其滤液，合并两次滤液；将滤液加入旋转蒸发仪中浓缩至滤液体积的1/2时停止浓缩，冷却浓缩液，得到中草药粗提液；离心中草药粗提液，取上清液，即得中草药提取物。The Chinese herbal medicine extract is extracted according to the following steps: mix each Chinese medicine raw material evenly, soak in pure water at 72°C, the solid-to-liquid ratio is 1:12, ultrasonically extract and extract for 2 hours, filter and take the filtrate, and add 8 times more to the filter residue Dosage of water continued to be ultrasonically extracted for 2 hours and filtered, and the filtrate was taken, and the two filtrates were combined; the filtrate was added to a rotary evaporator to concentrate to 1/2 of the volume of the filtrate, and the concentration was stopped, and the concentrated solution was cooled to obtain a crude extract of Chinese herbal medicine; the crude Chinese herbal medicine was centrifuged Extract the solution and take the supernatant to obtain the Chinese herbal medicine extract.
所述烟用香精为丁二酸二甲酯、吲哚、吡啶、3-乙酰基吡啶、3-乙基吡啶、2-甲基吡嗪、2,3,5-三甲基吡嗪中的混合物（质量比2.5：0.5：2：2：3：1.5：1）。The essence for tobacco is dimethyl succinate, indole, pyridine, 3-acetylpyridine, 3-ethylpyridine, 2-methylpyrazine, 2,3,5-trimethylpyrazine Mixture (mass ratio 2.5:0.5:2:2:3:1.5:1).
所述辅助材料包括防腐剂山梨酸、pH调节剂碳酸氢钠、甜味剂、溶剂（水和食用甘油的混合物）。The auxiliary materials include preservative sorbic acid, pH regulator sodium bicarbonate, sweetener, solvent (mixture of water and edible glycerin).
实施例7Example 7
同实施例6，区别在于：防腐剂为焦亚硫酸钾、pH调节剂为山梨酸。Same as Example 6, the difference is that the preservative is potassium metabisulfite, and the pH regulator is sorbic acid.
实施例8Example 8
同实施例6，区别在于：防腐剂为焦亚硫酸钠、pH调节剂为磷酸氢二钠。Same as Example 6, the difference is that the preservative is sodium metabisulfite, and the pH regulator is disodium hydrogen phosphate.
实施例9Example 9
同实施例6，区别在于：防腐剂为亚硫酸氢钠。With embodiment 6, difference is: preservative is sodium bisulfite.
实施例10Example 10
同实施例6，区别在于：防腐剂为亚硫酸钠。With embodiment 6, difference is: preservative is sodium sulfite.
实施例11Example 11
同实施例6，区别在于：防腐剂为低亚硫酸钠。With embodiment 6, difference is: preservative is low sodium sulfite.
实施例12Example 12
同实施例6，区别在于：防腐剂为对羟基苯甲酸酯。With embodiment 6, difference is: preservative is paraben.
实施例13Example 13
同实施例6，区别在于：防腐剂为对羟基苯甲酸乙酯。With embodiment 6, difference is: preservative is ethyl p-hydroxybenzoate.
实施例14Example 14
同实施例6，区别在于：防腐剂为对羟基苯甲酸乙酯钠盐。Same as Example 6, the difference is that the preservative is ethyl p-hydroxybenzoate sodium salt.
显然，本发明的上述实施例仅仅是为清楚地说明本发明所作的举例，而并非是对本发明的实施方式的限定，对于所属领域的普通技术人员来说，在上述说明的基础上还可以做出其它不同形式的变化或变动，这里无法对所有的实施方式予以穷举，凡是属于本发明的技术方案所引伸出的显而易见的变化或变动仍处于本发明的保护范围之列。Apparently, the above-mentioned embodiments of the present invention are only examples for clearly illustrating the present invention, and are not intended to limit the implementation of the present invention. Those of ordinary skill in the art can also make It is impossible to exhaustively list all the implementation modes here, and any obvious changes or changes derived from the technical solutions of the present invention are still within the scope of protection of the present invention.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410026989.3ACN103750538B (en) | 2014-01-21 | 2014-01-21 | A kind of throat-clearing throat-moistening type tobacco oral spray agent and preparation method thereof |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410026989.3ACN103750538B (en) | 2014-01-21 | 2014-01-21 | A kind of throat-clearing throat-moistening type tobacco oral spray agent and preparation method thereof |
| Publication Number | Publication Date |
|---|---|
| CN103750538A CN103750538A (en) | 2014-04-30 |
| CN103750538Btrue CN103750538B (en) | 2016-03-23 |
| Application Number | Title | Priority Date | Filing Date |
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| CN201410026989.3AActiveCN103750538B (en) | 2014-01-21 | 2014-01-21 | A kind of throat-clearing throat-moistening type tobacco oral spray agent and preparation method thereof |
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