CN103584845A - Method for measuring pulse signal transmission time difference - Google Patents
Method for measuring pulse signal transmission time differenceDownload PDFInfo
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- CN103584845A CN103584845ACN201310543880.2ACN201310543880ACN103584845ACN 103584845 ACN103584845 ACN 103584845ACN 201310543880 ACN201310543880 ACN 201310543880ACN 103584845 ACN103584845 ACN 103584845A
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Abstract
Description
Technical field
The present invention relates to a kind of measuring method of pulse signal transmission time difference.
Background technology
Arteriosclerosis can make that ductus arteriosus wall thickens, hardening, follows the string, luminal stenosis.Arteriosclerosis is with age and the angiopathy that occurs, and its rule normally occurs at adolescence, increases the weight of period, falls ill to person in middle and old age.Male is many compared with women, and primary disease increases gradually in China in recent years, becomes one of old people's main cause of death.In recent years, due to the positive correlation of pulse wave transmission speed PWV and arteriosclerosis degree, add its measuring method simple and easy to do and there is no a wound, so, be widely used and be used as assessing an index of arteriosclerosis degree.
PWV, refers to the spread speed of pulse wave between two of Arterial system had both fixed a point, and according to Moens-Korteweg equation, PWV is directly proportional to the square root of coefficient of elasticity, and due to the attenuating of arterial elasticity, pulse wave has been accelerated in the spread speed of Arterial system.In normal situation, PWV increases along with the increase at age.Generally PWV normal value is: 45 years old following adult's <9 meter per second (m/s); 45 years old above <10m/s.PWV is higher, promptingarteriosclerosisdegree is heavier.
In existing measuring method, due to pulse wave be subject to the impact of measurement system noise and pulse wave signal itself very faint, cause the measurement accuracy of pulse signal transmission time difference undesirable, affected the measurement result of pulse wave transmission speed as judging basic reliability.
The problems referred to above are the problems that should pay attention to and solve in the measuring process of pulse signal transmission time difference.
Summary of the invention
The measuring method that the object of this invention is to provide a kind of pulse signal transmission time difference solves in existing measuring method, due to pulse wave be subject to the impact of measurement system noise and pulse wave signal itself very faint, cause the measurement accuracy of pulse signal transmission time difference undesirable, affected the measurement result of pulse wave transmission speed as the problem of judging basic reliability.
Technical solution of the present invention is:
A measuring method for pulse signal transmission time difference, for measuring the time difference between the arterial pulse signal at two different limbs positions of measured, said method comprising the steps of:
By the first cuff colligation at measured one upper limb position, by the second cuff colligation at measured one lower limb position;
Described the first cuff and the second cuff are connected by gas link and a measurement main frame, and described measurement main frame comprises the first pressure transducer, the second pressure transducer, the first gas bleeder valve, the second gas bleeder valve, one or more than one air pump;
Use microprocessor, process the first cuff obtaining by the first pressure transducer, the second pressure transducer, pressure signal and/or the pulse signal in the second cuff, described microprocessor is carried out the process of the measurement pulse signal time difference comprising the following steps:
A) by the first air pump in described the first cuff, the first gas bleeder valve, the first pressure transducer, an air pump or an above air pump, measure described artery of upper extremity blood pressure, and measure and make pulse signal amplitude in the first cuff reach maximum cuff pressure P1A simultaneously; By the second air pump in described the second cuff, the second gas bleeder valve, the second pressure transducer, an air pump or an above air pump, measure described artery of lower extremity blood pressure, and measure and make pulse signal amplitude in the second cuff reach maximum cuff pressure P2A simultaneously;
B) by the first air pump in a described air pump or an above air pump, described the first cuff is pressurized to a force value in P1A or the upper next given range of P1A, by the second air pump in a described air pump or an above air pump, the second cuff is pressurized to a force value in P2A or the upper next given range of P2A, then by described first and second pressure transducers, measures respectively three or three above pulse signals in described the first and second cufves simultaneously;
C) calculate the time difference between in described the second cuff three or three above pulse signals and described the first cuff three or three pulse signals above.
Preferably, the upper next given range of described P1A is P1A ± 10mmHg, and the upper next given range of described P2A is P2A ± 10mmHg.
Preferably, described step C) for determining the time difference between described pulse signal by calculating the peaked time of correlation function between in described the second cuff three or three above pulse signals and described the first cuff three or three above pulse signals.
Preferably, described step C) be specially:
If the wave function y (t) of the n of described the second cuff pulse signal C2A, 0≤t≤T, the wave function of the n of described the first cuff pulse signal C1A is x (t), 0≤t≤T, the correlation function R (τ) that calculates described y (t) and x (t), computing formula is
, more corresponding τ-value when calculating described correlation function R (τ) and getting maximum, establishing described τ-value isτ 0,τ 0 is exactly measured's pulse signal transmission time difference.
Preferably, described step C) be specially:
If the pulse signal wave function of the n of described the second cuff pulse signal C2A is respectively q1 (t), q2 (t) ... qn (t), and 0≤t≤T, the pulse signal wave function of the n of described the first cuff pulse signal C1A is p1 (t), p2 (t) ... pn (t), and 0≤t≤T, calculates respectively the correlation function Ri (τ) of qi (t) and pi (t), 0≤i≤n and be integer wherein, computing formula is
corresponding τ-value when calculating respectively more described n correlation function R1 (τ) and getting maximum to Rn (τ), if described τ-value is respectivelyτ 1,τ 2... τ n, then calculate the meansigma methods that describedτ 1 arrives τ n, described meansigma methods is exactly measured's pulse signal transmission time difference.
Preferably, calculate a given number in eight to 16 in the pulse signal of a given number in eight to 16 in described the second cuff and described the first cuff pulse signal between time difference, with this, determine measured's arteriosclerosis degree.
Preferably, use pressurization measurement method or decompression measurement method, for the air pressure P1 (t) and the pulse signal A1 (t) that detect described the first cuff by described the first pressure transducer, when tri-continuous pulse signal A1 (t1) constantly of t1, t2 and t3 being detected, A1 (t2), when A1 (t3) meets A1 (t1) < A1 (t2) > A1 (t3) and is related to, t2 constantly corresponding air pressure be that target is pressed P1A.
Preferably, use pressurization measurement method or decompression measurement method, for the air pressure P2 (t) and the pulse signal A2 (t) that detect described the second cuff by described the second pressure transducer, when tri-continuous pulse signal A2 (t21) constantly of t21, t22 and t23 being detected, A2 (t22), when A2 (t23) meets A2 (t21) < A2 (t22) > A2 (t23) and is related to, t22 constantly corresponding air pressure be that target is pressed P2A.
The invention has the beneficial effects as follows: the measuring method of a kind of pulse signal transmission time difference of the present invention, can measure reliably, accurately and quickly pulse signal transmission time difference, have simple to operate, measure fast and the low advantage of cost, can guarantee that the measurement result of pulse signal transmission time difference is as judging basic reliability.
accompanying drawing explanation
Fig. 1 is the structure explanation block diagram of the embodiment of the present invention one;
Fig. 2 is the structure explanation block diagram of the embodiment of the present invention two;
Fig. 3 is the structure explanation block diagram of the embodiment of the present invention three;
Fig. 4 is the structural representation of the embodiment of the present invention;
Fig. 5 is decompression measurement method the first cuff and the second cuff adds, decompression and pulse signal sequential chart;
Fig. 6 is pulse signal enlarged diagram in Fig. 5;
Fig. 7 is pressurization measurement method the first cuff and the second cuff adds, decompression and pulse signal sequential chart;
Fig. 8 is pulse signal enlarged diagram in Fig. 7.
Wherein: 1-the first cuff, 2-the second cuff, 3-main frame, 4-the first trachea, 5-the second trachea;
Pressure signal or pulse signal curve when C1-the first cuff is inflated or loses heart, pressure signal or pulse signal curve when C2-the second cuff is inflated or loses heart.
The specific embodiment
Below in conjunction with accompanying drawing, describe the preferred embodiments of the present invention in detail.
As shown in Fig. 4, Fig. 5 or Fig. 7, a kind of measuring method of pulse signal transmission time difference, for measuring the time difference between the arterial pulse signal at two different limbs positions of measured, said method comprising the steps of:
By thefirst cuff 1 colligation at measured one upper limb position, by thesecond cuff 2 colligations at measured one lower limb position;
Described thefirst cuff 1 and thesecond cuff 2 are connected by gas link and a measurement main frame 3, and described measurement main frame 3 comprises the first pressure transducer, the second pressure transducer, the first gas bleeder valve, the second disappointing two, one or more than one air pump;
Use microprocessor, process thefirst cuff 1 obtaining by the first pressure transducer, the second pressure transducer, pressure signal and/or the pulse signal in thesecond cuff 2, described microprocessor is carried out the process of the measurement pulse signal time difference comprising the following steps:
A) by the first air pump in described thefirst cuff 1, the first gas bleeder valve, the first pressure transducer, an air pump or an above air pump, measure described artery of upper extremity blood pressure, and measure and make pulse signal amplitude in thefirst cuff 1 reach maximum cuff pressure P1A simultaneously; By the second air pump in described thesecond cuff 2, the second gas bleeder valve, the second pressure transducer, an air pump or an above air pump, measure described artery of lower extremity blood pressure, and measure and make pulse signal amplitude in thesecond cuff 2 reach maximum cuff pressure P2A simultaneously;
B) by the first air pump in an air pump or an above air pump, described thefirst cuff 1 is pressurized to a force value in P1A or the upper next given range of P1A, by the second air pump in an air pump or an above air pump, thesecond cuff 2 is pressurized to a force value in P2A or the upper next given range of P2A, then by described first and second pressure transducers, measures respectively three or three above pulse signals in described the first andsecond cufves 2 simultaneously;
C) calculate the time difference between in described thesecond cuff 2 three or three above pulse signals and described thefirst cuff 1 three or three pulse signals above.
As shown in Figure 1, Figure 2 or shown in Fig. 3, a kind of arteriosclerosis measuring device, comprises main frame 3, and thefirst cuff 1 being connected with main frame 3 respectively and the second cuff 2.Thefirst cuff 1 is a upper arm cuff, for being bundled in a tested upper limb, can block the blood flow of tested artery of upper extremity after inflation completely, and is connected with the upper limb air bag interface of main frame 3 by the first trachea 4.Thesecond cuff 2 is ankle cufves, for being bundled in tested lower limb, can block the blood flow of tested artery of lower extremity after inflation completely, and is connected with the lower limb air bag interface of main frame 3 by the second trachea 5.The first pressure transducer and the second pressure transducer join with thefirst cuff 1 and thesecond cuff 2 respectively by gas link, described the first pressure transducer and the second pressure transducer detect respectively force value and/or the pulse signal in thefirst cuff 1 and thesecond cuff 2 simultaneously, according to pulse signal and the atmospheric pressure value in described thefirst cuff 1 and thesecond cuff 2, determine systolic pressure and the diastolic pressure of tested artery of upper extremity, and the systolic pressure of artery of lower extremity and diastolic pressure.According to the systolic pressure of described artery of upper extremity, diastolic pressure and pulse signal, and the systolic pressure of described artery of lower extremity, diastolic pressure and pulse signal, determine measured's pulse signal transmission time difference.
Described main frame 3 comprises microprocessor, the human-computer interaction interface being connected with microprocessor respectively, the first pressure transducer, the second pressure transducer, gas charging system, the system of losing heart, and the upper limb air bag interface and the lower limb air bag interface that are connected with thesecond cuff 2 with thefirst cuff 1 respectively.Human-computer interaction interface is the human-computer interaction interface that comprises keyboard, display.Gas charging system comprises one or more than one air pump.Disappointing system comprises one or more than one gas bleeder valve.
Gas link is that one or more parts in trachea, joint, switch valve, three-way air valve form.
Embodiment mono-
For Fig. 1, there are successively following two kinds of steps:
The first step, for Fig. 5, has following steps:
1) thefirst cuff 1 and thesecond cuff 2 are bundled in respectively on a tested upper limb and tested lower limb, and are connected with lower limb air bag interface with the upper limb air bag interface on main frame 3 respectively with the second trachea 5 by the first trachea 4;
2) press the start key of main frame 3 keyboards, the first and second gas bleeder valves cut out, and the first and second air pumps are respectively to thefirst cuff 1 and thesecond cuff 2 inflations, and the air pressure of thefirst cuff 1 and thesecond cuff 2 increases from zero;
3) when the air pressure in thefirst cuff 1 and thesecond cuff 2 is greater than systolic pressure respectively, close the first and second air pumps, stop inflation;
4) control the first and second gas bleeder valves, respectively thefirst cuff 1 and thesecond cuff 2 are slowly lost heart, in thefirst cuff 1 and the slow disappointing process of thesecond cuff 2, by the first pressure transducer and the second pressure transducer, detect respectively air pressure and the pulse signal constantly changing in thefirst cuff 1 and thesecond cuff 2, according to described pulse signal and atmospheric pressure value, utilize oscillographic method principle, determine respectively the systolic pressure of tested artery of upper extremity and tested artery of lower extremity;
5) continue thefirst cuff 1 and thesecond cuff 2 slowly to lose heart, in thefirst cuff 1 and the slow disappointing process of thesecond cuff 2, by the first pressure transducer and the second pressure transducer, detect respectively air pressure and the pulse signal constantly changing in thefirst cuff 1 and thesecond cuff 2, according to described pulse signal and atmospheric pressure value, a target of definite tested artery of upper extremity and tested artery of lower extremity is pressed P1A and P2A respectively, determines the following 5-1 of method difference of this target pressure P1A and P2A) and 5-2):
5-1) for detect air pressure and the pulse signal of thefirst cuff 1 by the first pressure transducer, waveform is as shown in the P1 of Fig. 5 (t) and A1 (t), when tri-continuous pulse signal A1 (t1) constantly of t1, t2 and t3 being detected, A1 (t2), when A1 (t3) meets A1 (t1) < A1 (t2) > A1 (t3) and is related to, t2 constantly corresponding air pressure be that target is pressed P1A;
5-2) for detect air pressure and the pulse signal of thesecond cuff 2 by the second pressure transducer, waveform is as shown in the P2 of Fig. 5 (t) and A2 (t), when tri-continuous pulse signal A2 (t21) constantly of t21, t22 and t23 being detected, A2 (t22), when A21 (t23) meets A2 (t21) < A2 (t22) > A2 (t23) and is related to, t22 constantly corresponding air pressure be that target is pressed P2A;
6) continue thefirst cuff 1 and thesecond cuff 2 slowly to lose heart, in thefirst cuff 1 and the slow disappointing process of thesecond cuff 2, by the first pressure transducer and the second pressure transducer, detect respectively air pressure and the pulse signal constantly changing in thefirst cuff 1 and thesecond cuff 2, according to described pulse signal and atmospheric pressure value, utilize oscillographic method principle, determine respectively the diastolic pressure of tested artery of upper extremity and tested artery of lower extremity;
7) air pressure of thefirst cuff 1 and thesecond cuff 2 is increased to respectively to target and presses within the scope of P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, this step has two kinds of embodiments, respectively following 7-1) and 7-2):
7-1) close the first and second gas bleeder valves, open the first and second air pumps, respectively to thefirst cuff 1 and thesecond cuff 2 pressurizations, the air pressure of thefirst cuff 1 and thesecond cuff 2 is increased to respectively to target presses within the scope of P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, for example the air pressure of thefirst cuff 1 and thesecond cuff 2 is increased to respectively to target and presses P1A and P2A, close the first and second air pumps, stop pressurization;
7-2) open the first and second gas bleeder valves, give respectively thefirst cuff 1 and thesecond cuff 2 venting, until discharge, then wait for a period of time, close again the first and second gas bleeder valves, open the first and second air pumps, respectively to thefirst cuff 1 and thesecond cuff 2 pressurizations, the air pressure of thefirst cuff 1 and thesecond cuff 2 is increased to respectively to target presses within the scope of P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, for example the air pressure of thefirst cuff 1 and thesecond cuff 2 is increased to respectively to target and presses P1A and P2A, close the first and second air pumps, stop pressurization;
8) by the first pressure transducer and the second pressure transducer, detect respectively three or three above pulse signals in thefirst cuff 1 and thesecond cuff 2, according to the pulse signal of described thefirst cuff 1 and thesecond cuff 2, determine measured's pulse signal transmission time difference.The method of determining measured's pulse signal transmission time difference has two kinds, respectively following 8-1) and 8-2):
8-1) by the first pressure transducer and the second pressure transducer, detect respectively in thefirst cuff 1 and thesecond cuff 2 pulse signal of a given number in eight to 16, calculate the pulse signal of the described given number in thesecond cuff 2 and the described given number in thefirst cuff 1 pulse signal between time difference, for example given number is 12, its waveform is as shown in C2A and C1A in Fig. 6, first calculate d1=t26-t6, d2=t27-t7, d3=t28-t8, d4=t29-t9, d5=t30-t10, d6=t31-t11, d7=t32-t12, d8=t33-t13, d9=t34-t14, d10=t35-t15, d11=t36-t16, d12=t37-t17, calculate again the meansigma methods of d1 ~ d12, described meansigma methods is exactly measured's pulse signal transmission time difference,
8-2) by the first pressure transducer and the second pressure transducer, detect respectively three or three above pulse signals in thefirst cuff 1 and thesecond cuff 2, the peaked time of correlation function between pulse signal of calculating described in pulse signal described in thesecond cuff 2 and thefirst cuff 1 is determined the time difference between described pulse signal, for example given number is 12, its waveform is as shown in C2A and C1A in Fig. 6, account form has two kinds, respectively following 8-2-1) and 8-2-2):
8-2-1) establish the wave function y (t) of 12 pulse signal C2A of thesecond cuff first cuff 1 is x (t), 0≤t≤T, the correlation function R (τ) that calculates y (t) and x (t), computing formula is
, more corresponding τ-value when calculating described correlation function R (τ) and getting maximum, establishing described τ-value isτ 0,τ 0 is exactly measured's pulse signal transmission time difference;
The pulse signal wave function of 8-2-2) establishing 12 pulse signal C2A of the second cuff 2 is respectively q1 (t), q2 (t), q3 (t), q4 (t), q5 (t), q6 (t), q7 (t), q8 (t), q9 (t), q10 (t), q11 (t), q12 (t), and 0≤t≤T, the pulse signal wave function of 12 pulse signal C1A of the first cuff 1 is p1 (t), p2 (t), p3 (t), p4 (t), p5 (t), p6 (t), p7 (t), p8 (t), p9 (t), p10 (t), p11 (t), p12 (t), and 0≤t≤T, calculate respectively the correlation function Ri (τ) of qi (t) and pi (t), 0≤i≤12T and be integer wherein, computing formula is
corresponding τ-value when calculating respectively again 12 correlation function R1 (τ) and getting maximum to R12 (τ), if described τ-value is respectively τ 1, τ 2, τ 3, τ 4, τ 5, τ 6, τ 7, τ 8, τ 9, τ 10, τ 11 and τ 12, the meansigma methods of calculating again τ 1 to τ 12, described meansigma methods is exactly measured's pulse signal transmission time difference,
9) open the first and second gas bleeder valves, lose heart to thefirst cuff 1 and thesecond cuff 2.
The second step, for Fig. 7, has following steps:
1) thefirst cuff 1 and thesecond cuff 2 are bundled in respectively on a tested upper limb and tested lower limb, and are connected with lower limb air bag interface with the upper limb air bag interface on main frame 3 respectively with the second trachea 5 by the first trachea 4;
2) press the start key of main frame 3 keyboards, the first and second gas bleeder valves cut out, and the first and second air pumps are respectively to thefirst cuff 1 and thesecond cuff 2 inflations, and the air pressure of thefirst cuff 1 and thesecond cuff 2 slowly increases from zero;
3) in to the process of thefirst cuff 1 and thesecond cuff 2 slow pressurizations, by the first pressure transducer and the second pressure transducer, detect respectively air pressure and the pulse signal constantly changing in thefirst cuff 1 and thesecond cuff 2, according to described pulse signal and atmospheric pressure value, utilize oscillographic method principle, determine respectively the diastolic pressure of tested artery of upper extremity and tested artery of lower extremity;
4) continue thefirst cuff 1 and thesecond cuff 2 slowly to pressurize, in the process of thefirst cuff 1 and thesecond cuff 2 slow pressurizations, by the first pressure transducer and the second pressure transducer, detect respectively air pressure and the pulse signal constantly changing in thefirst cuff 1 and thesecond cuff 2, according to described pulse signal and atmospheric pressure value, a target of definite tested artery of upper extremity and tested artery of lower extremity is pressed P1A and P2A respectively, determines the following 4-1 of method difference of this target pressure P1A and P2A) and 4-2):
4-1) for detect air pressure and the pulse signal of thefirst cuff 1 by the first pressure transducer, waveform is as shown in the P1 of Fig. 7 (t) and A1 (t), when tri-continuous pulse signal A1 (t41) constantly of t41, t42 and t43 being detected, A1 (t42), when A1 (t43) meets A1 (t41) < A1 (t42) > A1 (t43) and is related to, t42 constantly corresponding air pressure be that target is pressed P1A;
4-2) for detect air pressure and the pulse signal of thesecond cuff 2 by the second pressure transducer, waveform is as shown in the P2 of Fig. 6 (t) and A2 (t), when tri-continuous pulse signal A2 (t61) constantly of t61, t62 and t63 being detected, A2 (t62), when A2 (t63) meets A2 (t61) < A2 (t62) > A2 (t63) and is related to, t162 constantly corresponding air pressure be that target is pressed P2A;
5) continue thefirst cuff 1 and thesecond cuff 2 slowly to pressurize, in the process of thefirst cuff 1 and thesecond cuff 2 slow pressurizations, by the first pressure transducer and the second pressure transducer, detect respectively air pressure and the pulse signal constantly changing in thefirst cuff 1 and thesecond cuff 2, according to described pulse signal and atmospheric pressure value, utilize oscillographic method principle, determine respectively the systolic pressure of tested artery of upper extremity and tested artery of lower extremity;
6) air pressure of thefirst cuff 1 and thesecond cuff 2 reduced respectively or be increased within the scope of target pressure P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, this step has two kinds of embodiments, respectively following 6-1) and 6-2):
6-1) open the first gas bleeder valve and the second gas bleeder valve, respectively thefirst cuff 1 and thesecond cuff 2 are lost heart, the air pressure of thefirst cuff 1 and thesecond cuff 2 is reduced to respectively to target presses within the scope of P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, for example the air pressure of thefirst cuff 1 and thesecond cuff 2 is reduced to respectively to target and press P1A and P2A, close the first gas bleeder valve and the second gas bleeder valve, stop losing heart;
6-2) open the first gas bleeder valve and the second gas bleeder valve, give respectively thefirst cuff 1 and thesecond cuff 2 venting, until discharge, then wait for a period of time, close again the first gas bleeder valve and the second gas bleeder valve, open the first air pump and the second air pump, respectively to thefirst cuff 1 and thesecond cuff 2 pressurizations, the air pressure of thefirst cuff 1 and thesecond cuff 2 is increased to respectively to target presses within the scope of P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, for example the air pressure of thefirst cuff 1 and thesecond cuff 2 is increased to respectively to target and presses P1A and P2A, close the first air pump and the second air pump, stop pressurization,
7) by the first pressure transducer and the second pressure transducer, detect respectively three or three above pulse signals in thefirst cuff 1 and thesecond cuff 2, according to the pulse signal of described thefirst cuff 1 and thesecond cuff 2, determine measured's pulse signal transmission time difference.The method of determining measured's pulse signal transmission time difference has two kinds, respectively following 7-1) and 7-2):
7-1) by the first pressure transducer and the second pressure transducer, detect respectively in thefirst cuff 1 and thesecond cuff 2 pulse signal of a given number in eight to 16, calculate the pulse signal of the described given number in thesecond cuff 2 and the described given number in thefirst cuff 1 pulse signal between time difference, for example given number is 12, its waveform is as shown in C2A and C1A in Fig. 8, first calculate d21=t66-t46, d22=t67-t47, d23=t68-t48, d24=t69-t49, d25=t70-t50, d26=t71-t51, d27=t72-t52, d28=t73-t53, d29=t74-t54, d30=t75-t55, d31=t76-t56, d32=t77-t57, calculate again the meansigma methods of d21 ~ d32, described meansigma methods is exactly measured's pulse signal transmission time difference,
7-2) by the first pressure transducer and the second pressure transducer, detect respectively three or three above pulse signals in thefirst cuff 1 and thesecond cuff 2, the peaked time of correlation function between pulse signal of calculating described in pulse signal described in thesecond cuff 2 and thefirst cuff 1 is determined the time difference between described pulse signal, for example given number is 12, its waveform is as shown in C2A and C1A in Fig. 8, account form has two kinds, respectively following 7-2-1) and 7-2-2):
7-2-1) establish the wave function y (t) of 12 pulse signal C2A of thesecond cuff first cuff 1 is x (t), 0≤t≤T, the correlation function R (τ) that calculates y (t) and x (t), computing formula is
, more corresponding τ-value when calculating described correlation function R (τ) and getting maximum, establishing described τ-value isτ 0,τ 0 is exactly measured's pulse signal transmission time difference;
The pulse signal wave function of 7-2-2) establishing 12 pulse signal C2A of the second cuff 2 is respectively q1 (t), q2 (t), q3 (t), q4 (t), q5 (t), q6 (t), q7 (t), q8 (t), q9 (t), q10 (t), q11 (t), q12 (t), and 0≤t≤T, the pulse signal wave function of 12 pulse signal C1A of the first cuff 1 is p1 (t), p2 (t), p3 (t), p4 (t), p5 (t), p6 (t), p7 (t), p8 (t), p9 (t), p10 (t), p11 (t), p12 (t), and 0≤t≤T, calculate respectively the correlation function Ri (τ) of qi (t) and pi (t), 0≤i≤12 and be integer wherein, computing formula iscorresponding τ-value when calculating respectively again 12 correlation function R1 (τ) and getting maximum to R12 (τ), if described τ-value is respectively τ 1, τ 2, τ 3, τ 4, τ 5, τ 6, τ 7, τ 8, τ 9, τ 10, τ 11 and τ 12, the meansigma methods of calculating again τ 1 to τ 12, described meansigma methods is exactly measured's pulse signal transmission time difference,
8) open the first gas bleeder valve and the second gas bleeder valve, lose heart to thefirst cuff 1 and thesecond cuff 2.
Embodiment bis-
As shown in Figure 2, there is following a kind of step:
For Fig. 5, only need to use the first step of Fig. 1, and by thestep 2 in described step), 3) and 7) use respectively following steps 2), 3) and 7) replacement:
2) press the start key of main frame 3 keyboards, the first gas bleeder valve and the second gas bleeder valve are closed, timesharing is opened the first switch valve, closes second switch valve, opens air pump to thefirst cuff 1 inflation and is opened second switch valve, closes the first switch valve, opens air pump to thesecond cuff 2 inflations, and the air pressure of thefirst cuff 1 and thesecond cuff 2 increases from zero;
3) when the air pressure in thefirst cuff 1 and thesecond cuff 2 is greater than systolic pressure respectively, close air pump, stop inflation;
7) air pressure of thefirst cuff 1 and thesecond cuff 2 is increased to respectively to target and presses within the scope of P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, this step has two kinds of embodiments, respectively following 7-1) and 7-2):
7-1) close the first gas bleeder valve and the second gas bleeder valve, timesharing is opened the first switch valve, closes second switch valve, opens air pump to thefirst cuff 1 inflation and is opened second switch valve, closes the first switch valve, opens air pump to thesecond cuff 2 inflations, the air pressure of thefirst cuff 1 and thesecond cuff 2 is increased to respectively to target presses within the scope of P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, for example the air pressure of thefirst cuff 1 and thesecond cuff 2 is increased to respectively to target and presses P1A and P2A, close air pump, stop pressurization;
7-2) open the first gas bleeder valve and the second gas bleeder valve, give respectively thefirst cuff 1 and thesecond cuff 2 venting, until discharge, then wait for a period of time, close again the first gas bleeder valve and the second gas bleeder valve, the first switch is opened in timesharing, close second switch valve, open air pump to thefirst cuff 1 inflation and open second switch valve, close the first switch valve, open air pump to thesecond cuff 2 inflations, the air pressure of thefirst cuff 1 and thesecond cuff 2 is increased to respectively to target presses within the scope of P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, for example the air pressure of thefirst cuff 1 and thesecond cuff 2 is increased to respectively to target and presses P1A and P2A, close air pump, stop pressurization.
Embodiment tri-
As shown in Figure 3, there is following a kind of step:
For Fig. 5, only need to use the first step of Fig. 1, and by thestep 2 in described step), 3) and 7) use respectively following steps 2), 3) and 7) replacement:
2) press the start key of main frame 3 keyboards, the first gas bleeder valve and the second gas bleeder valve are closed, timesharing is connected three-way air valve air pump and thefirst cuff 1, is opened air pump and connect air pump and thesecond cuff 2, open air pump to thesecond cuff 2 inflations to thefirst cuff 1 inflation with by three-way air valve, and the air pressure of thefirst cuff 1 and thesecond cuff 2 increases from zero;
3) when the air pressure in thefirst cuff 1 and thesecond cuff 2 is greater than systolic pressure respectively, close air pump, stop inflation;
7) air pressure of thefirst cuff 1 and thesecond cuff 2 is increased to respectively to target and presses within the scope of P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, this step has two kinds of embodiments, respectively following 7-1) and 7-2):
7-1) close the first gas bleeder valve and the second gas bleeder valve, timesharing is connected three-way air valve air pump and thefirst cuff 1, is opened air pump and connect air pump and thesecond cuff 2, open air pump to thesecond cuff 2 inflations to thefirst cuff 1 inflation with by three-way air valve, the air pressure of thefirst cuff 1 and thesecond cuff 2 is increased to respectively to target presses within the scope of P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, for example the air pressure of thefirst cuff 1 and thesecond cuff 2 is increased to respectively to target and presses P1A and P2A, close air pump, stop pressurization;
7-2) open the first gas bleeder valve and the second gas bleeder valve, give respectively thefirst cuff 1 and thesecond cuff 2 venting, until discharge, then wait for a period of time, close again the first gas bleeder valve and the second gas bleeder valve, timesharing is connected air pump and thefirst cuff 1 by three-way air valve, open air pump to thefirst cuff 1 inflation and three-way air valve is connected to air pump and thesecond cuff 2, open air pump to thesecond cuff 2 inflations, the air pressure of thefirst cuff 1 and thesecond cuff 2 is increased to respectively to target presses within the scope of P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, for example the air pressure of thefirst cuff 1 and thesecond cuff 2 is increased to respectively to target and presses P1A and P2A, close air pump, stop pressurization.
Above content is further to convert in detail brightly in conjunction with concrete preferred implementation is made for the present invention, can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention; make without departing from the inventive concept of the premise some alternative or obvious modification that are equal to; and performance or purposes identical, all should be considered as belonging to the present invention by the definite patent protection model of submitted to claims with.
Claims (8)
1. a measuring method for pulse signal transmission time difference, for measuring the time difference between the arterial pulse signal at two different limbs positions of measured, is characterized in that, said method comprising the steps of:
By the first cuff colligation at measured one upper limb position, by the second cuff colligation at measured one lower limb position;
Described the first cuff and the second cuff are connected by gas link and a measurement main frame, and described measurement main frame comprises the first pressure transducer, the second pressure transducer, the first gas bleeder valve, the second gas bleeder valve, one or more than one air pump;
Use microprocessor, process the first cuff obtaining by the first pressure transducer, the second pressure transducer, pressure signal and/or the pulse signal in the second cuff, described microprocessor is carried out the process of the measurement pulse signal time difference comprising the following steps:
A) by the first air pump in described the first cuff, the first gas bleeder valve, the first pressure transducer, an air pump or an above air pump, measure described artery of upper extremity blood pressure, and measure and make pulse signal amplitude in the first cuff reach maximum cuff pressure P1A simultaneously; By the second air pump in described the second cuff, the second gas bleeder valve, the second pressure transducer, an air pump or an above air pump, measure described artery of lower extremity blood pressure, and measure and make pulse signal amplitude in the second cuff reach maximum cuff pressure P2A simultaneously;
B) by the first air pump in a described air pump or an above air pump, described the first cuff is pressurized to a force value in P1A or the upper next given range of P1A, by the second air pump in a described air pump or an above air pump, described the second cuff is pressurized to a force value in P2A or the upper next given range of P2A, then by described first and second pressure transducers, measures respectively three or three above pulse signals in described the first and second cufves simultaneously;
C) calculate the time difference between in described the second cuff three or three above pulse signals and described the first cuff three or three pulse signals above.
2. the measuring method of pulse signal transmission time difference as claimed in claim 1, is characterized in that: the upper next given range of described P1A is P1A ± 10mmHg, and the upper next given range of described P2A is P2A ± 10mmHg.
3. the measuring method of pulse signal transmission time difference as claimed in claim 1, it is characterized in that, by calculating the time difference between definite described pulse signal of peaked time of correlation function between in described the second cuff three or three above pulse signals and described the first cuff three or three above pulse signals.
4. the method for calculating pulse signal transmission time difference as claimed in claim 3, is characterized in that, described computational methods are specially:
If the wave function y (t) of the n of described the second cuff pulse signal C2A, 0≤t≤T, the wave function of the n of described the first cuff pulse signal C1A is x (t), 0≤t≤T, the correlation function R (τ) that calculates described y (t) and x (t), computing formula is
, more corresponding τ-value when calculating described correlation function R (τ) and getting maximum, establishing described τ-value is τ 0, τ 0 is exactly measured's pulse signal transmission time difference.
5. the method for calculating pulse signal transmission time difference as claimed in claim 3, is characterized in that, described computational methods are specially:
If the pulse signal wave function of the n of described the second cuff pulse signal C2A is respectively q1 (t), q2 (t) ... qn (t), and 0≤t≤T, the pulse signal wave function of the n of described the first cuff pulse signal C1A is p1 (t), p2 (t) ... pn (t), and 0≤t≤T, calculates respectively the correlation function Ri (τ) of described qi (t) and pi (t), 0≤i≤n and be integer wherein, computing formula is
corresponding τ-value when calculating respectively more described n correlation function R1 (τ) and getting maximum to Rn (τ), if described τ-value is respectively τ 1, τ 2... τ n, then calculate the meansigma methods that described τ 1 arrives τ n, described meansigma methods is exactly measured's pulse signal transmission time difference.
6. the measuring method of pulse signal transmission time difference as claimed in claim 1, it is characterized in that: calculate a given number in eight to 16 in the pulse signal of a given number in eight to 16 in described the second cuff and described the first cuff pulse signal between time difference, with this, determine measured's arteriosclerosis degree.
7. the measuring method of the pulse signal transmission time difference as described in claim 1-6 any one, it is characterized in that: use pressurization measurement method or decompression measurement method, for the air pressure P1 (t) and the pulse signal A1 (t) that detect described the first cuff by described the first pressure transducer, when tri-continuous pulse signal A1 (t1) constantly of t1, t2 and t3 being detected, A1 (t2), when A1 (t3) meets A1 (t1) < A1 (t2) > A1 (t3) and is related to, t2 constantly corresponding air pressure be that target is pressed P1A.
8. the measuring method of the pulse signal transmission time difference as described in claim 1-6 any one, it is characterized in that: use pressurization measurement method or decompression measurement method, for the air pressure P2 (t) and the pulse signal A2 (t) that detect described the second cuff by described the second pressure transducer, when tri-continuous pulse signal A2 (t21) constantly of t21, t22 and t23 being detected, A2 (t22), when A2 (t23) meets A2 (t21) < A2 (t22) > A2 (t23) and is related to, t22 constantly corresponding air pressure be that target is pressed P2A.
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