技术领域technical field
本发明涉及医药技术领域，具体涉及一种给药系统。The invention relates to the technical field of medicine, in particular to a drug delivery system.
背景技术Background technique
透皮给药系统是指在皮肤表面给药，使药物以恒定速率或接近恒定速率通过皮肤进入体循环，产生全身或局部治疗作用的新剂型。其优点体现在：药物吸收不受消化道内PH、食物、转运时间等因素影响；避免肝脏受过效应；克服因吸收过快产生血液浓度过高而引起的不良反应；可持续控制给药速度、灵活给药等。The transdermal drug delivery system refers to a new dosage form that is administered on the surface of the skin so that the drug enters the systemic circulation through the skin at a constant rate or near a constant rate to produce systemic or local therapeutic effects. Its advantages are as follows: drug absorption is not affected by factors such as PH in the digestive tract, food, and transit time; avoids liver over-effect; overcomes adverse reactions caused by excessive blood concentration caused by excessive absorption; sustainable control of drug administration speed, flexible medication etc.
但是现有的透皮给药系统常存在对药物分子量及极性有所限制等缺陷，还存在送药剂量不容易控制、透气性差等问题。However, the existing transdermal drug delivery systems often have defects such as restrictions on the molecular weight and polarity of the drug, and there are also problems such as difficult control of the drug delivery dose and poor air permeability.
另外现有的透皮给药系统还存在渗透速度慢、药物利用不够充分等缺点。In addition, the existing transdermal drug delivery system also has disadvantages such as slow penetration rate and insufficient drug utilization.
发明内容Contents of the invention
本发明的目的在于，提供一种超声波及静电复合透皮给药系统，解决以上技术问题。The object of the present invention is to provide an ultrasonic and electrostatic composite transdermal drug delivery system to solve the above technical problems.
本发明所解决的技术问题可以采用以下技术方案来实现：The technical problem solved by the present invention can adopt following technical scheme to realize:
超声波及静电复合透皮给药系统，包括一隔离层，设置在所述隔离层内侧的含药压敏胶层，其特征在于，所述隔离层的外侧设有一采用驻极体材料制成的驻极体层，所述含药压敏胶层的内侧设有一控释膜层；Ultrasonic and electrostatic composite transdermal drug delivery system, comprising an isolation layer, a drug-containing pressure-sensitive adhesive layer arranged on the inner side of the isolation layer, characterized in that an electret material is provided on the outer side of the isolation layer. Electret layer, the inner side of the drug-containing pressure-sensitive adhesive layer is provided with a controlled-release film layer;
由外及内依次排布有所述驻极体层、所述隔离层、所述含药压敏胶层和所述控释膜层，形成一贮库型贴剂；The electret layer, the isolation layer, the drug-containing pressure-sensitive adhesive layer and the controlled-release film layer are sequentially arranged from the outside to the inside to form a storage-type patch;
所述含药压敏胶层外侧贴有一超声波发生层，超声波发生层连接有一超声波发生电路。An ultrasonic generating layer is pasted on the outside of the drug-containing pressure-sensitive adhesive layer, and the ultrasonic generating layer is connected with an ultrasonic generating circuit.
超声波发生层发出的超声波作用于所述含药压敏胶层，可以提高药物活性、提高皮肤内水分活性促进药物吸收。The ultrasonic wave emitted by the ultrasonic wave generating layer acts on the drug-containing pressure-sensitive adhesive layer, which can increase the activity of the drug, increase the water activity in the skin, and promote the absorption of the drug.
同时超声波产生的声压会作用在含药压敏胶层以及皮肤上，通过声压促使药物吸收。At the same time, the sound pressure generated by the ultrasonic wave will act on the drug-containing pressure-sensitive adhesive layer and the skin, and promote drug absorption through the sound pressure.
所述超声波发生层可以设置在所述隔离层与所述含药压敏胶层之间，也可以设置在所述驻极体层与所述隔离层之间，或者也可以设置在所述驻极体层外侧。The ultrasonic generating layer can be arranged between the isolation layer and the drug-containing pressure-sensitive adhesive layer, or between the electret layer and the isolation layer, or can also be arranged between the isolation layer and the drug-containing pressure-sensitive adhesive layer. outside the polar body layer.
所述超声波发生层采用一压电陶瓷层。以便简化结构和利于贴近皮肤。The ultrasonic generating layer adopts a piezoelectric ceramic layer. In order to simplify the structure and facilitate close to the skin.
所述超声波及静电复合透皮给药系统还包括一柔性基体，所述贮库型贴剂设置在所述柔性基体上，所述柔性基体的面积大于所述贮库型贴剂面积；所述超声波发生电路设置在所述贮库型贴剂边侧的所述柔性基体上。The ultrasonic and electrostatic composite transdermal drug delivery system also includes a flexible substrate, the reservoir-type patch is arranged on the flexible substrate, and the area of the flexible substrate is larger than the area of the reservoir-type patch; The ultrasonic generating circuit is arranged on the flexible base at the side of the storage-type patch.
柔性基体采用布料，所述布料中含有10%~50%罗布麻纤维。罗布麻纤维能发出8~15微米的远红外光波，86%的辐射率，远红外光波作用于蔬菜水果等食品，既无毒性反应，又能减缓食品的维生素氧化，水分的流失，起到保鲜功效。含有罗布麻纤维的本发明，既不会影响袋子本身的作用，又具有保鲜作用。The flexible substrate adopts cloth, and the cloth contains 10% to 50% apocynum fiber. Apocynum fiber can emit far-infrared light waves of 8-15 microns, with a radiation rate of 86%. Far-infrared light waves act on vegetables and fruits and other foods, which has no toxic reaction, and can slow down the oxidation of vitamins and water loss in food, and play a role in preserving freshness. effect. The present invention containing the apocynum fiber will not affect the function of the bag itself, but also has the effect of keeping fresh.
所述布料中内含有铜离子。所述铜离子抗菌效果好、抗菌范围广，且对物品无毒性反应。罗布麻纤维与铜离子的复合材料抗菌能力更强，且由于铜离子的作用，使所述抗菌层呈蓝色，所述袋子主体内侧设有抗菌层的本发明内侧也呈蓝色，使用美观大方。The cloth contains copper ions. The copper ion has good antibacterial effect, wide antibacterial range and no toxic reaction to articles. The composite material of apocynum fiber and copper ions has stronger antibacterial ability, and due to the effect of copper ions, the antibacterial layer is blue, and the inner side of the bag main body provided with the antibacterial layer is also blue, which is beautiful to use Generous.
所述布料中内含有内还含有5%~30%AB抗菌纤维，所述AB抗菌纤维具有消灭金黄色葡萄球菌、白色葡萄球菌、白念珠菌、枯草杆菌、大肠杆菌、淋球菌、嗜盐菌、绿脓杆菌、伤寒杆菌、乙型链球菌等十五种细菌的作用，杀菌效果好，使用安全可靠。The cloth also contains 5%~30% AB antibacterial fiber, and the AB antibacterial fiber has the function of eliminating Staphylococcus aureus, Staphylococcus albus, Candida albicans, Bacillus subtilis, Escherichia coli, Neisseria gonorrhoeae, and halophilic bacteria , Pseudomonas aeruginosa, typhoid bacillus, Streptococcus type B and other fifteen kinds of bacteria, the bactericidal effect is good, and the use is safe and reliable.
所述超声波发生电路设有一电源接口，通过所述电源接口连接一电源。本发明优选不在超声波及静电复合透皮给药系统上内置电池，以避免因为电池液泄露造成环境污染。The ultrasonic generating circuit is provided with a power interface through which a power supply is connected. The present invention preferably does not have a built-in battery in the ultrasonic and electrostatic compound transdermal drug delivery system, so as to avoid environmental pollution caused by battery liquid leakage.
所述驻极体层外侧还贴有一金属电极层。以改善性能。A metal electrode layer is pasted on the outside of the electret layer. to improve performance.
所述含药压敏胶层内还分布有永磁体粉末颗粒。永磁体粉末颗粒可以采用汝铁硼永磁体粉末颗粒。通过磁场可以促进分子活性，特别可以促进人体内水分子的活性。Permanent magnet powder particles are also distributed in the drug-containing pressure-sensitive adhesive layer. The permanent magnet powder particles can adopt RuFeB permanent magnet powder particles. Molecular activity can be promoted through magnetic fields, especially the activity of water molecules in the human body.
所述含药压敏胶层内还分布有托玛琳粉末颗粒。Tourmaline powder particles are also distributed in the drug-containing pressure-sensitive adhesive layer.
托玛琳又称为碧玺。将托玛琳粉末颗粒混合在所述含药压敏胶层内，具有促进人体血液循环、提高细胞活性、改善驻极体电场、对人体进行矿物质补充等优点。Tourmaline is also known as tourmaline. Mixing tourmaline powder particles in the drug-containing pressure-sensitive adhesive layer has the advantages of promoting human blood circulation, increasing cell activity, improving electret electric field, and supplementing minerals to human body.
本发明的贮库型贴剂既能避免口服剂型对胃肠道的刺激，也克服了其他促渗方法的使用不便、对药物分子量及极性有所限制等缺陷；同时能降低全身血药浓度，提高局部患处药物浓度；通过给药面积的调整可控制给药剂量，药物以零级控释，24小时持续释放药物，从而使疗效持久平稳；只需揭去贴剂即可中断给药，使用方便。驻极体可以长期储存空间电荷和偶极电荷，其化学稳定性好、抗潮湿性能好、表面点位高、电荷稳定性好、驱动力强、完全满足透皮吸收的特殊要求。本发明采用驻极体作为物理调控因子，可作为离子驱动源对皮肤提供静电场和微电流，调控皮肤的驻极态、电结构和增强离子型药物透皮吸收。The storage-type patch of the present invention can not only avoid the stimulation of the gastrointestinal tract by the oral dosage form, but also overcome the disadvantages of inconvenient use and limitations on the molecular weight and polarity of the drug by other penetration-enhancing methods; at the same time, it can reduce the blood drug concentration in the whole body , increase the drug concentration in the local affected area; the dosage can be controlled through the adjustment of the administration area, the drug is released in zero order, and the drug is released continuously for 24 hours, so that the curative effect is lasting and stable; the administration can be interrupted only by removing the patch. Easy to use. Electrets can store space charges and dipole charges for a long time. They have good chemical stability, good moisture resistance, high surface points, good charge stability, strong driving force, and fully meet the special requirements of transdermal absorption. The invention adopts the electret as a physical regulating factor, which can be used as an ion driving source to provide an electrostatic field and a microcurrent to the skin, regulate the electret state and electrical structure of the skin, and enhance the transdermal absorption of ionic drugs.
本发明的给药系统具备制备方法简单、透皮效果好、药量成份可控并缓释、透气性好、对皮肤无刺激、便于操作等六大特点。The drug delivery system of the present invention has six characteristics, such as simple preparation method, good transdermal effect, controllable dosage and sustained release of ingredients, good air permeability, no irritation to skin, and easy operation.
所述驻极体层可以采用非多孔式的驻极体层。可以采用多孔式的驻极体层。The electret layer may be a non-porous electret layer. A porous electret layer may be used.
所述含药压敏胶层内还设有均匀分散在所述基质中的增粘剂、透皮促进剂和抗氧剂。以便更好的一起协同促渗。The drug-containing pressure-sensitive adhesive layer is also provided with a tackifier, a skin penetration accelerator and an antioxidant uniformly dispersed in the matrix. In order to better work together to promote penetration.
附图说明Description of drawings
图1为本发明的部分结构示意图。Fig. 1 is a partial structural schematic diagram of the present invention.
具体实施方式detailed description
为了使本发明实现的技术手段、创作特征、达成目的与功效易于明白了解，下面结合具体图示进一步阐述本发明。In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further described below in conjunction with specific diagrams.
参照图1，超声波及静电复合透皮给药系统，包括一隔离层2，设置在隔离层2内侧的含药压敏胶层4，隔离层2的外侧设有一采用驻极体材料制成的驻极体层1，含药压敏胶层4的内侧设有一控释膜层5。由外及内依次排布有驻极体层1、隔离层2、含药压敏胶层4和控释膜层5，形成一贮库型贴剂。含药压敏胶层4外侧贴有一超声波发生层，超声波发生层连接有一超声波发生电路。Referring to Fig. 1, the ultrasonic and electrostatic compound transdermal drug delivery system includes an isolation layer 2, a drug-containing pressure-sensitive adhesive layer 4 arranged on the inner side of the isolation layer 2, and an electret material is arranged on the outer side of the isolation layer 2. The inner side of the electret layer 1 and the drug-containing pressure-sensitive adhesive layer 4 is provided with a controlled-release film layer 5 . An electret layer 1, an isolation layer 2, a drug-containing pressure-sensitive adhesive layer 4 and a release-controlling film layer 5 are sequentially arranged from the outside to the inside to form a storage-type patch. An ultrasonic generating layer is pasted on the outer side of the drug-containing pressure-sensitive adhesive layer 4, and the ultrasonic generating layer is connected with an ultrasonic generating circuit.
超声波发生层发出的超声波作用于含药压敏胶层4，可以提高药物活性、提高皮肤内水分活性促进药物吸收。同时超声波产生的声压会作用在含药压敏胶层4以及皮肤上，通过声压促使药物吸收。The ultrasonic wave emitted by the ultrasonic wave generating layer acts on the drug-containing pressure-sensitive adhesive layer 4, which can increase the activity of the drug, increase the water activity in the skin, and promote the absorption of the drug. At the same time, the sound pressure generated by the ultrasonic waves will act on the drug-containing pressure-sensitive adhesive layer 4 and the skin, and promote drug absorption through the sound pressure.
超声波发生层可以设置在隔离层2与含药压敏胶层4之间，也可以设置在驻极体层1与隔离层2之间，或者也可以设置在驻极体层1外侧。超声波发生层采用一压电陶瓷层3。以便简化结构和利于贴近皮肤。The ultrasonic generating layer can be arranged between the isolation layer 2 and the drug-containing pressure-sensitive adhesive layer 4 , or between the electret layer 1 and the isolation layer 2 , or outside the electret layer 1 . The ultrasonic generating layer adopts a piezoelectric ceramic layer 3 . In order to simplify the structure and facilitate close to the skin.
超声波及静电复合透皮给药系统还包括一柔性基体，贮库型贴剂设置在柔性基体上，柔性基体的面积大于贮库型贴剂面积。超声波发生电路设置在贮库型贴剂边侧的柔性基体上。The ultrasonic and electrostatic compound transdermal drug delivery system also includes a flexible substrate, on which the reservoir-type patch is arranged, and the area of the flexible substrate is larger than that of the reservoir-type patch. The ultrasonic generating circuit is arranged on the flexible substrate at the side of the storage-type patch.
柔性基体采用布料，布料中含有10%~50%罗布麻纤维。罗布麻纤维能发出8~15微米的远红外光波，86%的辐射率，远红外光波作用于蔬菜水果等食品，既无毒性反应，又能减缓食品的维生素氧化，水分的流失，起到保鲜功效。含有罗布麻纤维的本发明，既不会影响袋子本身的作用，又具有保鲜作用。The flexible substrate adopts cloth, and the cloth contains 10%~50% apocynum fiber. Apocynum fiber can emit far-infrared light waves of 8-15 microns, with a radiation rate of 86%. The far-infrared light waves act on vegetables and fruits and other foods, which has no toxic reaction, and can slow down the oxidation of vitamins and water loss in food, and play a role in preserving freshness. effect. The present invention containing the apocynum fiber will not affect the function of the bag itself, but also has the effect of keeping fresh.
布料中内含有铜离子。铜离子抗菌效果好、抗菌范围广，且对物品无毒性反应。罗布麻纤维与铜离子的复合材料抗菌能力更强，且由于铜离子的作用，使抗菌层呈蓝色，袋子主体内侧设有抗菌层的本发明内侧也呈蓝色，使用美观大方。The fabric contains copper ions. Copper ions have good antibacterial effect, wide antibacterial range, and no toxic reaction to articles. The composite material of apocynum fiber and copper ions has stronger antibacterial ability, and due to the effect of copper ions, the antibacterial layer is blue, and the inner side of the bag main body provided with the antibacterial layer is also blue, which is elegant in use.
布料中内含有内还含有5%~30%AB抗菌纤维，AB抗菌纤维具有消灭金黄色葡萄球菌、白色葡萄球菌、白念珠菌、枯草杆菌、大肠杆菌、淋球菌、嗜盐菌、绿脓杆菌、伤寒杆菌、乙型链球菌等十五种细菌的作用，杀菌效果好，使用安全可靠。The fabric also contains 5%~30% AB antibacterial fiber, which can eliminate Staphylococcus aureus, Staphylococcus albicans, Candida albicans, Bacillus subtilis, Escherichia coli, Neisseria gonorrhoeae, halophilic bacteria, Pseudomonas aeruginosa , Typhoid bacillus, Streptococcus B and other fifteen kinds of bacteria, the bactericidal effect is good, and the use is safe and reliable.
超声波发生电路设有一电源接口，通过电源接口连接一电源。本发明优选不在超声波及静电复合透皮给药系统上内置电池，以避免因为电池液泄露造成环境污染。驻极体层1外侧还贴有一金属电极层。以改善性能。The ultrasonic generating circuit is provided with a power interface through which a power supply is connected. The present invention preferably does not have a built-in battery in the ultrasonic and electrostatic compound transdermal drug delivery system, so as to avoid environmental pollution caused by battery liquid leakage. A metal electrode layer is pasted on the outside of the electret layer 1 . to improve performance.
含药压敏胶层4内还分布有永磁体粉末颗粒6。永磁体粉末颗粒6可以采用汝铁硼永磁体粉末颗粒6。通过磁场可以促进分子活性，特别可以促进人体内水分子的活性。含药压敏胶层4内还分布有托玛琳粉末颗粒。Permanent magnet powder particles 6 are also distributed in the drug-containing pressure-sensitive adhesive layer 4 . The permanent magnet powder particles 6 can adopt RuFeB permanent magnet powder particles 6. Molecular activity can be promoted through magnetic fields, especially the activity of water molecules in the human body. Tourmaline powder particles are also distributed in the drug-containing pressure-sensitive adhesive layer 4 .
托玛琳又称为碧玺。将托玛琳粉末颗粒混合在含药压敏胶层4内，具有促进人体血液循环、提高细胞活性、改善驻极体电场、对人体进行矿物质补充等优点。Tourmaline is also known as tourmaline. Mixing tourmaline powder particles in the drug-containing pressure-sensitive adhesive layer 4 has the advantages of promoting human blood circulation, increasing cell activity, improving electret electric field, and supplementing minerals to the human body.
本发明的贮库型贴剂既能避免口服剂型对胃肠道的刺激，也克服了其他促渗方法的使用不便、对药物分子量及极性有所限制等缺陷；同时能降低全身血药浓度，提高局部患处药物浓度；通过给药面积的调整可控制给药剂量，药物以零级控释，24小时持续释放药物，从而使疗效持久平稳；只需揭去贴剂即可中断给药，使用方便。驻极体可以长期储存空间电荷和偶极电荷，其化学稳定性好、抗潮湿性能好、表面点位高、电荷稳定性好、驱动力强、完全满足透皮吸收的特殊要求。本发明采用驻极体作为物理调控因子，可作为离子驱动源对皮肤提供静电场和微电流，调控皮肤的驻极态、电结构和增强离子型药物透皮吸收。The storage-type patch of the present invention can not only avoid the stimulation of the gastrointestinal tract by the oral dosage form, but also overcome the disadvantages of inconvenient use and limitations on the molecular weight and polarity of the drug by other penetration-enhancing methods; at the same time, it can reduce the blood drug concentration in the whole body , increase the drug concentration in the local affected area; the dosage can be controlled through the adjustment of the administration area, the drug is released in zero order, and the drug is released continuously for 24 hours, so that the curative effect is lasting and stable; the administration can be interrupted only by removing the patch. Easy to use. Electrets can store space charges and dipole charges for a long time. They have good chemical stability, good moisture resistance, high surface points, good charge stability, strong driving force, and fully meet the special requirements of transdermal absorption. The invention adopts the electret as a physical regulating factor, which can be used as an ion driving source to provide an electrostatic field and a microcurrent to the skin, regulate the electret state and electrical structure of the skin, and enhance the transdermal absorption of ionic drugs.
本发明的给药系统具备制备方法简单、透皮效果好、药量成份可控并缓释、透气性好、对皮肤无刺激、便于操作等六大特点。驻极体层1可以采用非多孔式的驻极体层1。可以采用多孔式的驻极体层1。The drug delivery system of the present invention has six characteristics, such as simple preparation method, good transdermal effect, controllable dosage and sustained release of ingredients, good air permeability, no irritation to skin, and easy operation. The electret layer 1 may be a non-porous electret layer 1 . A porous electret layer 1 can be used.
含药压敏胶层4内还设有均匀分散在基质中的增粘剂、透皮促进剂和抗氧剂。以便更好的一起协同促渗。The drug-containing pressure-sensitive adhesive layer 4 is also provided with a tackifier, a skin penetration accelerator and an antioxidant uniformly dispersed in the matrix. In order to better work together to promote penetration.
以上显示和描述了本发明的基本原理和主要特征和本发明的优点。本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的只是说明本发明的原理，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。The basic principles and main features of the present invention and the advantages of the present invention have been shown and described above. Those skilled in the industry should understand that the present invention is not limited by the above-mentioned embodiments. What are described in the above-mentioned embodiments and the description only illustrate the principle of the present invention. Without departing from the spirit and scope of the present invention, the present invention will also have Variations and improvements are possible, which fall within the scope of the claimed invention. The protection scope of the present invention is defined by the appended claims and their equivalents.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210580806.3ACN103520829B (en) | 2012-12-27 | 2012-12-27 | Ultrasonicly involve static electricity compound transdermal delivery system |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210580806.3ACN103520829B (en) | 2012-12-27 | 2012-12-27 | Ultrasonicly involve static electricity compound transdermal delivery system |
| Publication Number | Publication Date |
|---|---|
| CN103520829A CN103520829A (en) | 2014-01-22 |
| CN103520829Btrue CN103520829B (en) | 2016-03-02 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210580806.3AActiveCN103520829B (en) | 2012-12-27 | 2012-12-27 | Ultrasonicly involve static electricity compound transdermal delivery system |
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|---|---|
| CN (1) | CN103520829B (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105816443A (en)* | 2016-01-05 | 2016-08-03 | 中国人民解放军第二军医大学 | GLP-1 sustained-release electret transdermal drug delivery system for treating diabetes |
| CN105816442A (en)* | 2016-01-05 | 2016-08-03 | 中国人民解放军第二军医大学 | 5-fluorouracil nanoparticle transdermal drug delivery electret preparation for treating hypertrophic scars based on action of electric field |
| CN106074460A (en)* | 2016-07-12 | 2016-11-09 | 中国人民解放军第二军医大学 | A transdermal preparation for inhibiting hypertrophic scar growth in combination with electret and 5-fluorouracil |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4734090A (en)* | 1986-07-18 | 1988-03-29 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator |
| CN101460214A (en)* | 2006-06-24 | 2009-06-17 | Lts勒曼治疗系统股份公司 | Transdermal therapeutic system reinforced by ultrasounds |
| CN202314980U (en)* | 2011-11-02 | 2012-07-11 | 四川康贝斯消毒药剂有限公司 | Heat release static physiotherapy patch |
| CN202397971U (en)* | 2011-11-18 | 2012-08-29 | 中国人民解放军第二军医大学 | Electret and microneedle transdermal delivery system |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7635488B2 (en)* | 2001-03-13 | 2009-12-22 | Dbv Technologies | Patches and uses thereof |
| CN101090012A (en)* | 2007-04-27 | 2007-12-19 | 新康电脑科技（苏州）有限公司 | Far infrared/strong magnetic fied function material |
| CN100560157C (en)* | 2007-11-13 | 2009-11-18 | 重庆市生力医疗设备有限公司 | Ultrasonic medicine plaster |
| US20100292632A1 (en)* | 2008-02-15 | 2010-11-18 | Mulvihill Maureen L | Transdermal Micro-Patch |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4734090A (en)* | 1986-07-18 | 1988-03-29 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator |
| CN101460214A (en)* | 2006-06-24 | 2009-06-17 | Lts勒曼治疗系统股份公司 | Transdermal therapeutic system reinforced by ultrasounds |
| CN202314980U (en)* | 2011-11-02 | 2012-07-11 | 四川康贝斯消毒药剂有限公司 | Heat release static physiotherapy patch |
| CN202397971U (en)* | 2011-11-18 | 2012-08-29 | 中国人民解放军第二军医大学 | Electret and microneedle transdermal delivery system |
| Publication number | Publication date |
|---|---|
| CN103520829A (en) | 2014-01-22 |
| Publication | Publication Date | Title |
|---|---|---|
| RU2232608C2 (en) | Device and method for transcutaneously delivering drug by means of electric transfer and method for producing the device | |
| Hao et al. | Stimuli‐Responsive Hydrogels for Antibacterial Applications | |
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