技术领域technical field
本发明涉及一种凝固剂和血管内取栓装置，可用于植入血管治疗血管栓塞病变，如脑卒中等。该装置为一种操作方便快捷的血管内取栓系统。The invention relates to a coagulant and an intravascular thrombus removal device, which can be used for implanting blood vessels to treat vascular embolism diseases, such as cerebral apoplexy and the like. The device is a convenient and fast intravascular thrombectomy system.
背景技术Background technique
血管栓塞是血管疾病中的常见病症，如急性缺血性脑卒中是由于脑部血流的突然阻塞而引起局部脑组织缺血坏死而致的神经组织损伤。70%~80%有严重症状需要做动脉造影的病人可以见到栓子或血栓的阻塞，而较大血管栓塞的致死率在53%~92%。血管的再通是治疗急性缺血性脑卒中的关键。目前，对于此类疾病的治疗方法主要有药物溶栓和机械取栓两大类。但从临床治疗的效果来看，药物溶栓和机械取栓都不是很理想。Vascular embolism is a common condition in vascular diseases. For example, acute ischemic stroke is the damage of nerve tissue caused by ischemic necrosis of local brain tissue caused by sudden blockage of blood flow in the brain. 70% to 80% of patients with severe symptoms requiring arteriography can see emboli or thrombus obstruction, and the fatality rate of large vessel embolism is 53% to 92%. Vascular recanalization is the key to the treatment of acute ischemic stroke. At present, the treatment methods for such diseases mainly include drug thrombolysis and mechanical thrombectomy. However, from the perspective of the effect of clinical treatment, drug thrombolysis and mechanical thrombectomy are not very ideal.
药物溶栓主要的问题体现在：若通过全身给药，容易引起出血并发症，且在溶栓过程中，栓子体积缩小后容易堵塞下游直径更小的血管；若采用介入溶栓（介入溶栓是指通过导管把溶栓剂注入病变所在的血管内的病灶附近，在病灶局部瞬间形成很高的溶栓剂浓度，加快血栓溶解速度，进而增加血管再通机会的一种药物溶栓方式），对于大部分绝对体积过大的能够抵抗酶的消化作用的血凝块，就需要极大剂量的溶栓药才能使其溶解，且需要一个相对比较长的治疗时间窗，这样容易引起各种并发症，风险较高。The main problems of drug thrombolysis are as follows: if it is administered systemically, it is easy to cause bleeding complications, and during the process of thrombolysis, the size of the embolus shrinks and it is easy to block the downstream blood vessels with smaller diameters; if interventional thrombolysis (interventional thrombolysis Thrombosis refers to injecting a thrombolytic agent into the vicinity of the lesion in the blood vessel where the lesion is located through a catheter, forming a high concentration of the thrombolytic agent in the local lesion instantly, accelerating the speed of thrombus dissolution, and increasing the chance of blood vessel recanalization. ), for most blood clots that are too large in absolute size and can resist digestion by enzymes, a very large dose of thrombolytic drugs is required to dissolve them, and a relatively long treatment time window is required, which is easy to cause various Complications are at high risk.
机械取栓的发展经历了以下几种方法：血栓切除术，这种方法取栓较为彻底，但是对血管壁损伤过大，极易引起各种并发炎症；激光碎栓，操作难度大，激光能量过低则无效，能量过高则损伤血管，同样易引起各种并发症；捕栓网取栓，操作简单，但因体积较大而无法在细小的如颅内血管内使用；抓捕器取栓，操作简单，对血管壁损伤很小但是抓捕器捕获栓子的过程中容易破坏栓子，从而产生更小的栓子。抓捕器捕获栓子之后，在抽取的过程中也容易使栓子产生破碎，细小的栓子会继续堵塞细小的血管。The development of mechanical thrombectomy has gone through the following methods: thrombectomy, which is more thorough in removing thrombus, but causes too much damage to the vessel wall and can easily cause various concurrent inflammations; laser thrombectomy is difficult to operate, and the laser energy If the energy is too low, it will be ineffective, if the energy is too high, it will damage the blood vessels, and it is also easy to cause various complications; the thrombus removal with the trapping net is easy to operate, but it cannot be used in small intracranial blood vessels due to its large size; The embolus is easy to operate and causes little damage to the vessel wall, but it is easy to destroy the embolus in the process of capturing the embolus by the catcher, resulting in smaller embolus. After the catcher captures the emboli, it is also easy to break the emboli during the extraction process, and the small emboli will continue to block the small blood vessels.
现有技术已教导了机械取栓装置及其治疗方法。例如，美国专利申请No.US2004/0068161A1公开了一种溶栓导管装置，其包括（a）伸长的溶栓导管部分，该部分含多个独立可控的电活性聚合物致动器，该致动器基于接受的控制信号为溶栓导管提供曲率；（b）控制单元，该控制单元与多个致动器耦联并将控制信号送至多个致动器；以及（c）栓塞去除装置。该申请还公开了一种治疗动脉栓塞的方法，该方法包括推进溶栓导管部分通过病人动脉血管，抵达临近栓塞的位置，同时利用控制单元控制溶栓导管部分的形状。然后，利用该栓塞去除装置除去栓塞。The prior art has taught mechanical thrombectomy devices and methods of treatment. For example, U.S. Patent Application No. US2004/0068161A1 discloses a thrombolytic catheter device comprising (a) an elongated thrombolytic catheter section containing a plurality of independently controllable electroactive polymer actuators, the an actuator providing curvature to the thrombolytic catheter based on received control signals; (b) a control unit coupled to the plurality of actuators and sending control signals to the plurality of actuators; and (c) an embolism removal device . The application also discloses a method for treating arterial embolism, the method comprising advancing the thrombolysis catheter portion through the patient's arterial vessel to a location adjacent to the embolism, while using a control unit to control the shape of the thrombolysis catheter portion. Then, the embolus is removed using the embolization device.
美国专利No.US5279546公开了一种用于溶解和去除往往堵塞诸如动脉的身体通道的材料的装置和方法。该装置采用以共轴方式布置的双导管系统。各个导管在其远端具有可膨胀的球囊。使两个球囊充气，堵塞治疗区近端和远端的身体通道，然后与身体其他部分的流体接触相分离。由于使用了同心导管，球囊间的距离以及由此治疗区的大小是可调节的。溶栓剂通过内导管的孔注入两个球囊之间的区域。压电装置在治疗区中供给超声搅拌。压力装置监控身体通道的危险状况。通过外导管的一个或多个腔完成吸出。超声搅拌还与吸出一起使用，以打碎太大不能通过出口腔横截面的材料团。US Patent No. US5279546 discloses a device and method for dissolving and removing material that tends to clog bodily passages such as arteries. The device employs a two-catheter system arranged in a coaxial fashion. Each catheter has an expandable balloon at its distal end. Both balloons are inflated to occlude body passages proximal and distal to the treatment area, and are then isolated from fluid contact with the rest of the body. Due to the use of concentric catheters, the distance between the balloons and thus the size of the treatment area is adjustable. A thrombolytic agent is injected through the hole in the inner catheter into the area between the two balloons. The piezoelectric device supplies ultrasonic agitation in the treatment zone. Pressure devices monitor body passages for dangerous conditions. Aspiration is accomplished through one or more lumens of the outer catheter. Ultrasonic agitation is also used in conjunction with suction to break up clumps of material that are too large to pass through the exit port cross-section.
美国专利申请No.20110098738公开了一种栓子俘获装置，用于俘获体腔内的栓子。该装置包括过滤篮以及至少一个与篮连接的圈。过滤篮包括框和至于框上的过滤体。至少一个圈与过滤体连接，用于过滤体腔中的栓子。US Patent Application No. 20110098738 discloses an embolic capture device for capturing emboli in a body cavity. The device includes a filter basket and at least one ring connected to the basket. The filter basket includes a frame and a filter body on the frame. At least one loop is connected with the filter body for filtering emboli in the body cavity.
中国专利申请公开号CN201058169也公开了一种同轴球囊溶栓导管。该申请的目的是提出一种能将药物溶栓、机械碎栓、球囊扩张于一体同步进行的脑血管治疗介入材料。该导管有效长度150厘米，远端直径3F，近端直径4F，由远到近逐渐增粗，平滑过渡；所述导管由导管头、导管干、导管尾构成，其特征在于，所述导管含有三个腔及一个球囊，所述三个腔同轴，在溶栓操作过程中由导管的尾端不断泵入溶栓药物或者其它药物，或注射造影剂，在操作的过程中持续不断的泵入溶栓药物，便于将机械碎栓溶栓球囊扩张同步进行，改变了以前反复更换导管、导丝、溶栓。Chinese patent application publication number CN201058169 also discloses a coaxial balloon thrombolysis catheter. The purpose of this application is to propose an interventional material for cerebrovascular therapy that can integrate drug thrombolysis, mechanical thrombus fragmentation, and balloon expansion simultaneously. The effective length of the catheter is 150 centimeters, the diameter of the distal end is 3F, and the diameter of the proximal end is 4F. Three cavities and one balloon, the three cavities are coaxial, during the thrombolytic operation, the thrombolytic drug or other drugs are continuously pumped from the tail end of the catheter, or the contrast agent is injected continuously. Pumping thrombolytic drugs facilitates the simultaneous expansion of mechanical thrombolysis and thrombolysis balloons, which changes the previous repeated replacement of catheters, guide wires, and thrombolysis.
现有技术还教导了血管栓塞剂及其应用。例如，美国专利申请No.US2009/0137981A1公开了治疗血管的方法。在具体实施方式中，治疗血管的方法包括在血管中提供至少一个可操作工具，将非固体可聚合材料沉积至血管的沉积区，其中可聚合液体在与血管中的血液接触后随时间固化，以及通过操作该工具在可聚合材料固化时改变其形状。The prior art also teaches vaso-embolic agents and their use. For example, US Patent Application No. US2009/0137981A1 discloses methods of treating blood vessels. In a particular embodiment, a method of treating a blood vessel comprises providing at least one operable means in the blood vessel to deposit a non-solid polymerizable material into a deposition zone of the blood vessel, wherein the polymerizable liquid solidifies over time upon contact with blood in the blood vessel, and by manipulating the tool to change the shape of the polymerizable material as it solidifies.
中国专利申请公开号CN86107191公开了一种血管栓塞剂的制备方法。该栓塞剂由α-氰基丙烯酸正辛酯、钽粉和碘油（或碘苯酯）配制而成，三者的体积百分比可为80-85:1-5:10-15，而以83.75:2.5:13.75为更佳，单组份稳定性好，使用方便。在体内聚合迅速，发热量小，聚合体柔软，不会被血液或组织液吸收降解而失效，能在X光照射下，体内聚合体显影的永久性血管栓塞材料。该材料栓塞剂可用玻璃注射器注射使用。Chinese Patent Application Publication No. CN86107191 discloses a preparation method of a vascular embolism agent. The embolic agent is formulated from n-octyl α-cyanoacrylate, tantalum powder and lipiodol (or iodophenyl ester), the volume percentage of the three can be 80-85:1-5:10-15, and 83.75 :2.5:13.75 is better, the single component has good stability and is easy to use. It is a permanent vascular embolism material that polymerizes quickly in vivo, has low calorific value, is soft, will not be absorbed and degraded by blood or tissue fluid, and can be visualized in vivo under X-ray irradiation. The embolism of this material can be injected with a glass syringe.
然而，仍需要一种全新的颅内血管快速取栓装置，这种新的装置可满足以下条件：1）取栓过程简单、方便；2）体积小，可以方便运送至颅内的远端血管；3）贴壁性和柔顺性好，捕获率高，支撑力适中，取栓过程中不会损伤血管内壁；4）捕获血栓后回收装置时，血栓固定牢固、不易脱落。However, there is still a need for a new rapid thrombectomy device for intracranial blood vessels, which can meet the following conditions: 1) The thrombectomy process is simple and convenient; 2) Small in size, it can be easily transported to the distal intracranial blood vessels ;3) Good adherence and flexibility, high capture rate, moderate support force, and no damage to the inner wall of the blood vessel during thrombus removal; 4) When the thrombus is captured and the device is recovered, the thrombus is firmly fixed and not easy to fall off.
发明内容Contents of the invention
针对上述技术问题，本发明提供一种凝固剂和血管内取栓装置，能获得很好的治疗血栓疾病的效果。In view of the above technical problems, the present invention provides a coagulant and an intravascular thrombus retrieval device, which can obtain a good effect in treating thrombotic diseases.
本发明涉及一种凝固剂，包括下式(1)所示的氰基丙烯酸烷基酯为主要成分，以及阻聚剂、增塑剂和显影剂：The present invention relates to a kind of coagulant, comprise the alkyl cyanoacrylate shown in following formula (1) as main component, and polymerization inhibitor, plasticizer and developing agent:
其中1≥n≥12，优选4≥n≥10，更优7≥n≥9，最优n=8。Among them, 1≥n≥12, preferably 4≥n≥10, more preferably 7≥n≥9, optimally n=8.
在凝固剂的具体实施方式中，以所述氰基丙烯酸烷基酯为基体计算，所述阻聚剂含量为0.001-0.5%，优选0.005-0.1%，所述增塑剂含量为10-50%，优选20-40%，更优选20-35%，所述显影剂含量为5-30%，优选8-20%，更优选10-12%。In a specific embodiment of the coagulant, based on the alkyl cyanoacrylate, the content of the polymerization inhibitor is 0.001-0.5%, preferably 0.005-0.1%, and the content of the plasticizer is 10-50% %, preferably 20-40%, more preferably 20-35%, the developer content is 5-30%, preferably 8-20%, more preferably 10-12%.
根据本发明，所述阻聚剂选自间甲氧基苯酚、对苯二酚、磷酸和二氧化硫；所述增塑剂选自邻苯二甲酸二甲酯、邻苯二甲酸二乙酯、邻苯二甲酸二丁酯、邻苯二甲酸丁苄酯、苯甲酸酯、柠檬酸酯和磷酸三甲酚酯；以及所述显影剂选自碘化物，铋化合物，金属粉末，或者它们的任意混合物，其中所述碘化物优选6-三碘甲酸、6-三碘苯甲酸钠、碘钛酸、甲泛影酸、碘达酸、碘克酸、碘帕酸、碘海醇和碘曲仑，更优选碘帕酸。According to the present invention, the polymerization inhibitor is selected from m-methoxyphenol, hydroquinone, phosphoric acid and sulfur dioxide; the plasticizer is selected from dimethyl phthalate, diethyl phthalate, ortho Dibutyl phthalate, butyl benzyl phthalate, benzoate, citrate, and tricresyl phosphate; and the developer is selected from iodide, bismuth compound, metal powder, or any mixture thereof , wherein said iodide is preferably 6-triiodoformic acid, 6-triiodobenzoic acid sodium, iodotitanic acid, metrizoic acid, iodacic acid, iocolic acid, iopamidic acid, iohexol and iotrolan, more preferably Iopamidic acid.
根据本发明，所述显影剂选自金粉、铂粉、钽粉、钛粉、钨粉和硫酸钡。According to the present invention, the developer is selected from gold powder, platinum powder, tantalum powder, titanium powder, tungsten powder and barium sulfate.
本发明涉及一种血管内取栓装置，包括本发明凝固剂和取栓器两部分。The invention relates to an intravascular thrombus removal device, which comprises two parts of the coagulant and a thrombus remover of the invention.
根据本发明，所述取栓器的材料选用生物相容性好的金属材料或/和高分子材料。According to the present invention, the material of the thrombus retriever is selected from metal materials or/and polymer materials with good biocompatibility.
根据本发明，所述取栓器是通过激光切割金属或者高弹性高分子管材，或者是先切割金属或者高分子片材然后卷曲、定型而成。According to the present invention, the thrombus retriever is formed by laser cutting metal or high elastic polymer tubes, or first cutting metal or polymer sheets and then crimping and shaping them.
根据本发明，所述取栓器由双球囊替代。According to the invention, the thrombus retriever is replaced by a double balloon.
根据本发明，所述取栓器的有效取栓长度为15～40mm，直径为2～6mm。According to the present invention, the effective length of the thrombus remover is 15-40 mm, and the diameter is 2-6 mm.
根据本发明，所述取栓器整体上呈类圆柱状。According to the present invention, the thrombus retriever is generally cylindrical in shape.
本发明的凝固剂主要成分为氰基丙烯酸烷基酯，在常温下呈液体，其结构如下式(1)示：Coagulant main component of the present invention is alkyl cyanoacrylate, is liquid at normal temperature, and its structure is shown in following formula (1):
如上述结构式(1)所示，该类烷基酯中含有氰基和羧基，其具有的双重吸电子作用可使α碳原子易受环境中的阴离子催化而迅速聚合固化，而血液中富含阴离子，因此在手术过程中极易引发凝结剂聚合而实现血栓的保护。As shown in the above structural formula (1), this kind of alkyl ester contains cyano group and carboxyl group, and its double electron-withdrawing effect can make the alpha carbon atom susceptible to anion catalysis in the environment and quickly polymerize and solidify, while blood is rich in Anion, so it is very easy to trigger the coagulation agent to polymerize during the operation to achieve the protection of thrombus.
本发明的血管内取栓装置分为两部分：其一为可保护血栓（血凝块）的凝固剂，该凝固剂使用前呈液体，通过微导管到达血栓附近，在血液中迅速固化成类似海绵状的固体且具有一定的柔韧性，可与血栓子的任何部位粘合形成一个整体，从而安全有效地阻止血栓子在取栓器撤回时形成细小栓子，方便医生操作；其二为取栓器，其中取栓器的有效取栓长度为15～40mm，直径为2～6mm。该取栓器整体呈类圆柱状，可以通过激光切割金属或高弹性高分子管材获得，也可以通过先切割金属或高分子片材然后经卷曲、定型成类圆柱状；该取栓器的关键在于不但可以牢固固定血栓，而且可以有效输送到远端血管。双球囊导管也可以为取栓器。The intravascular thrombus removal device of the present invention is divided into two parts: one is a coagulant that can protect thrombus (blood clot), the coagulant is liquid before use, reaches the vicinity of the thrombus through a microcatheter, and quickly solidifies in the blood into a similar Sponge-like solid with a certain degree of flexibility, it can be bonded to any part of the thrombus to form a whole, thus safely and effectively preventing the thrombus from forming a small embolus when the thrombus retriever is withdrawn, which is convenient for doctors to operate; Thrombectomy device, wherein the effective length of the thrombectomy device is 15-40 mm, and the diameter is 2-6 mm. The thrombus retriever has a cylindrical shape as a whole, and can be obtained by laser cutting metal or high-elastic polymer tubes, or by cutting metal or polymer sheets and then crimping and shaping them into a cylindrical shape; the key to the thrombus retriever The reason is that not only can the thrombus be firmly fixed, but also can be effectively transported to the distal blood vessels. A double balloon catheter can also be used as a thrombus retriever.
本发明取栓器的材料可选用生物相容性好的金属材料或/和高分子材料。所述取栓器可以是通过激光切割金属或者高弹性高分子管材，也可以是先切割金属或者高分子片材然后卷曲、定型而成，具有良好的径向支撑力，从鞘管中释放到血管后具有较好的血管贴壁性。所述取栓器可以由双球囊代替，只要能实现取栓功能即可。The material of the thrombus retriever of the present invention can be selected from metal materials or/and polymer materials with good biocompatibility. The thrombus remover can be made by laser cutting metal or high elastic polymer tubing, or by first cutting metal or polymer sheet and then crimping and shaping it. It has good radial support force and is released from the sheath to the Possesses good vascular adhesion after the blood vessel. The thrombus retriever can be replaced by double balloons, as long as the thrombectomy function can be realized.
本发明的血管内取栓装置具备如下特点：The intravascular thrombectomy device of the present invention has the following characteristics:
1）取栓器可被微导管、导管或专用输送器输送通过迂曲血管到达靶目标；1) The thrombus retriever can be delivered by a microcatheter, catheter or a special conveyor through tortuous blood vessels to reach the target;
2）凝固剂可通过微导管输送至血凝块，在血凝块近远两端瞬间固化形成柔韧的海绵体，将血凝块包在中间保护起来；2) The coagulant can be transported to the blood clot through a microcatheter, and instantly solidifies at the near and far ends of the blood clot to form a flexible spongy body, wrapping the blood clot in the middle and protecting it;
3）取栓器释放后可将包含血凝块的海绵体全部托住，并且不会产生任何细小栓子。3) After the thrombus retriever is released, it can fully hold the spongy body containing the blood clot without producing any tiny emboli.
相对于现有技术公开的取栓装置、溶栓导管及液体栓塞剂的使用方法，本发明提出了一种全新的结构设计理念，其中一方面凝固剂可与血栓（血凝块）的任何部位粘合形成一个柔韧的整体，不但可有效防止体积较小栓子的脱落，也可有效地阻止血栓在取栓器撤回时形成新的细小栓子，方便医生操作；另一方面由于血栓凝结成了一个柔韧的整体，对取栓器结构和性能的要求降低，取出更加方便，从而降低了取栓过程中并发症发生的概率，并节约了取栓成本。Compared with the thrombus removal device, thrombolytic catheter and liquid embolic agent disclosed in the prior art, the present invention proposes a brand-new structural design concept, wherein on the one hand, the coagulant can be combined with any part of the thrombus (blood clot) Bonding forms a flexible whole, which can not only effectively prevent small emboli from falling off, but also effectively prevent thrombus from forming new small emboli when the thrombus retriever is withdrawn, which is convenient for doctors to operate; A flexible whole is formed, the requirements for the structure and performance of the thrombectomy device are reduced, and the removal is more convenient, thereby reducing the probability of complications during the thrombectomy process and saving the cost of thrombectomy.
本发明的取栓装置能够方便、快捷地取出血栓，且安全有效。The thrombus removing device of the present invention can remove thrombus conveniently and quickly, and is safe and effective.
附图说明Description of drawings
为了更清楚地描述本发明的技术方案，下面将结合附图作简要介绍。显而易见，这些附图仅是本申请记载的一些具体实施方式。本发明的技术方案包括但不限于这些附图。In order to describe the technical solution of the present invention more clearly, a brief introduction will be given below in conjunction with the accompanying drawings. Obviously, these drawings are only some specific implementations described in this application. The technical solutions of the present invention include but are not limited to these drawings.
图1为一种血栓示意图；Fig. 1 is a kind of schematic diagram of thrombus;
图2显示取栓器到位；Figure 2 shows that the thrombus retriever is in place;
图3显示微导管到位，凝固剂从前段孔洞流出；以及Figure 3 shows the microcatheter in place and the coagulant flowing out of the front hole; and
图4显示凝固剂保护的血栓被安全取除。Figure 4 shows that a coagulant-protected thrombus was safely removed.
具体实施方式detailed description
为了进一步理解本发明，下面将结合实施例对本发明的优选方案进行描述。这些描述只是举例说明本发明凝固剂和血管内取栓装置的特征和优点，而非限制本发明的保护范围。In order to further understand the present invention, preferred solutions of the present invention will be described below in conjunction with examples. These descriptions are only examples to illustrate the characteristics and advantages of the coagulation agent and the intravascular thrombectomy device of the present invention, rather than limiting the protection scope of the present invention.
实施例一Embodiment one
按照以下步骤制备为了实现安全快捷在血管内取栓所用凝固剂的制备方案：Follow the steps below to prepare the coagulant preparation protocol for safe and quick intravascular thrombectomy:
将3mol氰基丙烯酸正辛酯的单体分散在室温氩气氛围中缓慢加入事先配好的含有0.05%阻聚剂间甲氧基苯酚、35%增塑剂柠檬酸酯和10%显影剂碘帕酸的分散体系中，搅拌直至分散均匀；装入容器中密封、灭菌后备用。Disperse 3mol of n-octyl cyanoacrylate monomer in an argon atmosphere at room temperature and slowly add the pre-prepared solution containing 0.05% polymerization inhibitor m-methoxyphenol, 35% plasticizer citrate and 10% developer iodine Stir in the dispersion system of palicic acid until it is evenly dispersed; put it into a container, seal it, and sterilize it for later use.
实施例二Embodiment two
按照以下步骤制备为了实现安全快捷在血管内取栓所用凝固剂的制备方案：Follow the steps below to prepare the coagulant preparation protocol for safe and quick intravascular thrombectomy:
将3mol氰基丙烯酸正辛酯的单体分散在室温氩气氛围中缓慢加入事先配好的含有0.03%阻聚剂对苯二酚、25%增塑剂邻苯二甲酸丁苄酯和10%显影剂钽粉的分散体系中，搅拌直至分散均匀；装入容器中密封、灭菌后备用。Disperse the monomer of 3mol n-octyl cyanoacrylate in an argon atmosphere at room temperature and slowly add the pre-prepared solution containing 0.03% polymerization inhibitor hydroquinone, 25% plasticizer butyl benzyl phthalate and 10% In the dispersion system of developer tantalum powder, stir until the dispersion is uniform; put it into a container, seal it, sterilize it and set it aside.
实施例三Embodiment Three
按照以下步骤制备为了实现安全快捷在血管内取栓所用凝固剂的制备方案：Follow the steps below to prepare the coagulant preparation protocol for safe and quick intravascular thrombectomy:
将3mol氰基丙烯酸正辛酯的单体分散在室温氩气氛围中缓慢加入事先配好的含有0.005%阻聚剂间甲氧基苯酚、20%增塑剂磷酸三甲酚酯和10%显影剂金粉的分散体系中，搅拌直至分散均匀；装入容器中密封、灭菌后备用。Disperse 3mol of n-octyl cyanoacrylate monomer in an argon atmosphere at room temperature and slowly add the pre-prepared solution containing 0.005% polymerization inhibitor m-methoxyphenol, 20% plasticizer tricresyl phosphate and 10% developer In the dispersion system of gold powder, stir until the dispersion is uniform; put it into a container, seal it, and sterilize it for later use.
参照附图，说明利用包括本发明凝固剂的血管内取栓装置实现完全取栓的过程。图1显示，由于某种病变引起在血管（1）中形成的血栓（2）即所谓栓子，其基本完全堵塞血流。图2显示取栓器（3）穿过血栓到达远端并撑开。图3显示带有孔洞（5）的微导管（4）到达血栓，凝固剂经孔洞（5）从微导管中流出，与血液接触后迅速凝固将血栓包围形成。图4显示血栓最终被凝固剂（6）包裹而实现完全取栓。Referring to the accompanying drawings, the process of using the intravascular thrombectomy device including the coagulant of the present invention to achieve complete thrombus removal is illustrated. Figure 1 shows a thrombus (2), a so-called embolus, formed in a blood vessel (1) due to a certain pathology, which essentially completely blocks the blood flow. Figure 2 shows the retriever (3) passing through the thrombus to the distal end and distracting. Figure 3 shows that the microcatheter (4) with the hole (5) reaches the thrombus, and the coagulant flows out of the microcatheter through the hole (5), and coagulates rapidly after contacting the blood to form the thrombus. Figure 4 shows that the thrombus was finally encapsulated by coagulant (6) to achieve complete thrombus removal.
以上实施例的说明只是用于帮助理解本发明的核心思想。应当指出，对于本领域的普通技术人员而言，在不脱离本发明原理的前提下，还可以对本发明装置进行若干改进和修饰，但这些改进和修饰也落入本发明权利要求请求保护的范围内。The descriptions of the above embodiments are only used to help understand the core idea of the present invention. It should be pointed out that for those skilled in the art, without departing from the principle of the present invention, some improvements and modifications can also be made to the device of the present invention, but these improvements and modifications also fall within the scope of protection claimed by the claims of the present invention Inside.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210191643.XACN103480046B (en) | 2012-06-12 | 2012-06-12 | A kind of coagulant and Ink vessel transfusing get pin device |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210191643.XACN103480046B (en) | 2012-06-12 | 2012-06-12 | A kind of coagulant and Ink vessel transfusing get pin device |
| Publication Number | Publication Date |
|---|---|
| CN103480046A CN103480046A (en) | 2014-01-01 |
| CN103480046Btrue CN103480046B (en) | 2016-03-30 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210191643.XAExpired - Fee RelatedCN103480046B (en) | 2012-06-12 | 2012-06-12 | A kind of coagulant and Ink vessel transfusing get pin device |
| Country | Link |
|---|---|
| CN (1) | CN103480046B (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86107191A (en)* | 1986-10-13 | 1988-04-27 | 西安化工研究所 | Vasoembolic agent (TH glue) |
| CN1072867A (en)* | 1992-09-12 | 1993-06-09 | 山东省千佛山医院 | The conduit of fetching intravascular thrombus in human internal organ |
| CN101917927A (en)* | 2007-11-12 | 2010-12-15 | 维勒医学有限公司 | The single vial formulation of medical grade cyanoacrylate |
| CN102100932A (en)* | 2010-02-01 | 2011-06-22 | 微创医疗器械(上海)有限公司 | Liquid embolic material and preparation method thereof |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1244313C (en)* | 2003-01-07 | 2006-03-08 | 周星 | Recoverable blood vessel filter |
| CN101396295B (en)* | 2007-09-29 | 2010-11-03 | 成正辉 | Blood thrombus and embolus resectoscope |
| CN101912289B (en)* | 2010-08-25 | 2012-05-30 | 成正辉 | Thrombus excider and preparation method |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86107191A (en)* | 1986-10-13 | 1988-04-27 | 西安化工研究所 | Vasoembolic agent (TH glue) |
| CN1072867A (en)* | 1992-09-12 | 1993-06-09 | 山东省千佛山医院 | The conduit of fetching intravascular thrombus in human internal organ |
| CN101917927A (en)* | 2007-11-12 | 2010-12-15 | 维勒医学有限公司 | The single vial formulation of medical grade cyanoacrylate |
| CN102100932A (en)* | 2010-02-01 | 2011-06-22 | 微创医疗器械(上海)有限公司 | Liquid embolic material and preparation method thereof |
| Publication number | Publication date |
|---|---|
| CN103480046A (en) | 2014-01-01 |
| Publication | Publication Date | Title |
|---|---|---|
| JP6612616B2 (en) | Instruments and systems for thrombus treatment | |
| JP5089382B2 (en) | Embolic filter delivery system | |
| US20210219998A1 (en) | Stroke Catheter for Use in Revascularization Procedures and Method of Using Same | |
| US20200405336A1 (en) | Methods for restoring blood flow within blocked vasculature | |
| US6287271B1 (en) | Motion catheter | |
| JP4723189B2 (en) | Infusion catheter with atraumatic tip | |
| US8088140B2 (en) | Blood flow restorative and embolus removal methods | |
| CN112203593A (en) | Devices and methods for removing occlusive material from intravascular sites | |
| CN115177321A (en) | Multifunctional thrombus clearing device | |
| US20020058904A1 (en) | Thrombus removal device | |
| CN206852642U (en) | A kind of device for taking cerebrovascular thrombus | |
| BRPI0707681A2 (en) | Method and apparatus for increasing blood flow through a blocked artery | |
| US10485551B2 (en) | Methods of use of a balloon-tip aspiration catheter for ischemic stroke interventions | |
| EP1644069A1 (en) | Devices and methods for aspirating from filters | |
| US20240225686A1 (en) | Rotary embolectomy device | |
| CN211187437U (en) | Thrombus removal system | |
| CA2979816C (en) | Ischemic stroke thrombus aspiration system, processes, and products thereby | |
| CN116138841A (en) | Catheter system for extending catheters and removing embolic material from capillary vessels | |
| CN113855164A (en) | Net disc type mechanical thrombus removing catheter device | |
| EP1859826A1 (en) | Contrast agent-removal system and method of activating the contrast agent-removal system | |
| AU2008345624A1 (en) | Improved devices and methods for embolus removal during acute ischemic stroke | |
| CN103480046B (en) | A kind of coagulant and Ink vessel transfusing get pin device | |
| US20030199865A1 (en) | Thrombus treatment with emboli management | |
| CN115919412A (en) | Thrombectomy Device | |
| Benmira et al. | The start of a new era for stroke treatment: mechanical thrombectomy devices |
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right | Effective date of registration:20160223 Address after:201318 Shanghai city wide 222 Lane 16 Pudong New Area Road Applicant after:MICROPORT NEUROTECH (SHANGHAI) Co.,Ltd. Address before:201203 Shanghai City Newton Road, Pudong New Area Zhangjiang hi tech Park No. 501 Applicant before:SHANGHAI MICROPORT MEDICAL (GROUP) Co.,Ltd. | |
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee | Granted publication date:20160330 |