




【技术领域】【Technical field】
本发明涉及医疗器械领域,具体涉及一种可多次使用的多通道电极装置。The invention relates to the field of medical equipment, in particular to a multi-channel electrode device that can be used multiple times.
【背景技术】【Background technique】
20世纪40年代,随着技术和各种测量仪器的发展,科研人员能够从活体神经元中记录细胞内的电信号。通过用纤细的金属丝微电极和具有“箝位”配置的高增益的放大器,柯蒂斯和科尔记录了鱿鱼轴突内的电信号。该实验方法和数学模型为霍奇森和贺胥黎成功阐释离子膜电流在运动电位产生中的作用奠定了基础。他们的工作使神经元膜兴奋模型取代了早期伯恩斯坦的不同的钾离子膜渗透性模型,并为人们接受。霍奇森和贺胥黎由此获得了1963年的诺贝尔奖。更具意义的是,他们的模型预测了门控膜离子通道的存在。In the 1940s, with the development of technology and various measuring instruments, researchers were able to record intracellular electrical signals from living neurons. Using thin wire microelectrodes and high-gain amplifiers in a "clamp" configuration, Curtis and Cole recorded electrical signals inside squid axons. The experimental method and mathematical model laid the foundation for Hodgson and Huxley to successfully explain the role of ionic membrane current in the generation of motion potential. Their work made the neuronal membrane excitation model replace the earlier Bernstein's different potassium ion membrane permeability model, and it was accepted by people. Hodgson and Huxley won the Nobel Prize in 1963. More significantly, their model predicted the existence of gated membrane ion channels.
目前,神经元网络的研究引起了人们极大的兴趣;为了更好地理解中枢神经系统神经元之间复杂的相互关系,和为开发实用的神经假体提供所需的高度保真的知觉和控制信息,这就需要具备一种有选择且具有良好空间分辨率,能记录和控制神经组织行为的能力。这对正确理解脑组织和感官知觉的过程十分重要。而这方面的发展,与微电极技术的发展息息相关。它要求微电极能够传输高质量和稳定的刺激信号,同时又能够长时间记录大量的神经束的电信息。通过对神经系统的理解,更好地治疗与中枢神经系统有关的疾病变得更为切实可行。更好地理解神经图谱和对感知过程的理解,为感觉或运动受损的患者设计假体装置,使其恢复正常的功能,变的更加容易。Currently, the study of neuronal networks is of great interest; to better understand the complex interrelationships between neurons in the central nervous system, and to provide the high-fidelity perception and Controlling information requires the ability to selectively record and control the behavior of neural tissue with good spatial resolution. This is important for a proper understanding of brain organization and the processes of sensory perception. The development in this area is closely related to the development of microelectrode technology. It requires that microelectrodes can transmit high-quality and stable stimulation signals, and at the same time be able to record a large number of electrical information of nerve bundles for a long time. Better treatment of diseases related to the central nervous system becomes more feasible through an understanding of the nervous system. With a better understanding of the neural map and understanding of perceptual processes, it becomes easier to design prosthetic devices for patients with sensory or motor impairments to restore normal function.
现有技术中,神经电信号采集电极最常用的是犹他电极和密歇根电极,前者适合大脑浅层区域的研究,后者适宜较深核团不同层神经元放电的信号采集。但是这两种电极均价格昂贵,且不可重复使用。此外,这两种电极并不能满足所有的实验要求。为了降低实验成本和最大限度地满足实验要求,现有技术中使用较多的另一类电极是金属丝电极。金属丝电极的优点是通道数和记录位点可以根据需要进行选择,适用范围广。该类电极虽然成本较低,但是制备过程非常耗费人力和时间,且不能多次使用。In the prior art, the most commonly used electrodes for collecting neuroelectric signals are Utah electrodes and Michigan electrodes. The former is suitable for the study of superficial areas of the brain, and the latter is suitable for signal collection of neuron discharges in different layers of the deeper nuclei. But both electrodes are expensive and not reusable. Furthermore, these two electrodes do not meet all experimental requirements. In order to reduce the cost of the experiment and meet the requirements of the experiment to the greatest extent, another type of electrode that is widely used in the prior art is the wire electrode. The advantage of wire electrodes is that the number of channels and recording sites can be selected according to needs, and the application range is wide. Although the cost of this type of electrode is low, the preparation process is very labor-intensive and time-consuming, and cannot be used multiple times.
【发明内容】【Content of invention】
本发明的目的在于提供一种可多次使用的多通道电极装置,解决现有技术中电极价格昂贵、工艺耗时、不可多次使用等技术问题。The purpose of the present invention is to provide a multi-channel electrode device that can be used multiple times, so as to solve the technical problems in the prior art such as expensive electrodes, time-consuming process, and inability to be used multiple times.
本发明的目的可通过以下的技术措施来实现:The purpose of the present invention can be achieved through the following technical measures:
一种可多次使用的多通道电极装置,包括:A reusable multi-channel electrode device comprising:
电极主体,包括至少一个金属丝电极,所述金属丝电极的末端形成一用于采集生理电信号的采集端;The electrode body includes at least one wire electrode, and the end of the wire electrode forms a collection end for collecting physiological electrical signals;
与所述金属丝电极连接的电极接口;an electrode interface connected to the wire electrode;
连接所述电极接口、用于容纳所述金属丝电极的电极传动单元,所述采集端穿过所述电极传动单元;connecting the electrode interface and an electrode transmission unit for accommodating the wire electrode, and the collection end passes through the electrode transmission unit;
用于支撑所述电极接口的支撑部,所述采集端固定于所述支撑部。The supporting part is used to support the electrode interface, and the collecting end is fixed on the supporting part.
优选地,所述电极传动单元包括一用于容纳所述金属丝电极的空腔,所述空腔内设有一卷轴,绝缘管部分包裹所述金属丝电极,所述金属丝电极的两端裸露于所述绝缘管外,所述绝缘管缠绕于所述卷轴。Preferably, the electrode transmission unit includes a cavity for accommodating the wire electrode, a reel is arranged in the cavity, the insulating tube partially wraps the wire electrode, and both ends of the wire electrode are exposed Outside the insulating tube, the insulating tube is wound on the reel.
优选地,所述绝缘管由非金属柔性材料制成,所述非金属柔性材料包括硅橡胶或聚酰亚胺。Preferably, the insulating tube is made of non-metallic flexible material, and the non-metallic flexible material includes silicon rubber or polyimide.
优选地,所述装置还包括光纤,所述光纤的一端与光纤接口连接,所述光纤的另一端与所述采集端配置为可拆卸式连接结构。Preferably, the device further includes an optical fiber, one end of the optical fiber is connected to the optical fiber interface, and the other end of the optical fiber is configured as a detachable connection structure with the collection end.
优选地,所述光纤的另一端与所述采集端通过聚乙二醇封装连接。Preferably, the other end of the optical fiber is connected to the collecting end through polyethylene glycol encapsulation.
优选地,所述电极主体为单电极、双电极或四电极。Preferably, the electrode body is a single electrode, a double electrode or a quadruple electrode.
优选地,所述支撑部呈竖折状,由一长条形主体经两次弯折形成,所述长条形主体包括位于中间的第三主体及分别位于第三主体上下两侧的第一主体和第二主体,所述长条形主体相对于第三主体的中心点呈中心对称。Preferably, the support portion is vertically folded, and is formed by bending a strip-shaped main body twice. The main body and the second main body, the elongated main body is center-symmetrical with respect to the center point of the third main body.
优选地,所述电极接口为长方体型,所述电极接口设于所述第三主体。Preferably, the electrode interface is in the shape of a cuboid, and the electrode interface is provided on the third body.
优选地,所述金属丝电极的横截面直径为5-50μm。Preferably, the wire electrode has a cross-sectional diameter of 5-50 μm.
优选地,所述光纤横截面的直径为50-300μm。Preferably, the diameter of the optical fiber cross section is 50-300 μm.
本发明的有益效果在于,本发明的可多次使用的多通道电极装置含有电极传动单元,用于容纳金属丝电极,在采集端无法使用后,可对其进行截取,将容纳于电极传动单元的金属丝电极抽出,形成新的采集端,为可多次使用电极,降低成本;本发明的可多次使用的多通道电极装置使用的是金属丝电极,通道数和记录位点可以根据需要进行选择,适用范围广;本发明的可多次使用的多通道电极装置制备工艺简单,耗时少。The beneficial effect of the present invention is that the multiple-use multi-channel electrode device of the present invention contains an electrode transmission unit for accommodating wire electrodes, and after the collection end cannot be used, it can be intercepted and accommodated in the electrode transmission unit The metal wire electrode is drawn out to form a new collection terminal, so that the electrode can be used multiple times to reduce costs; the multi-channel electrode device that can be used multiple times in the present invention uses a wire electrode, and the number of channels and recording sites can be adjusted according to needs. It has a wide range of applications; the multiple-use multi-channel electrode device of the present invention has a simple preparation process and less time-consuming.
【附图说明】【Description of drawings】
图1是本发明实施例1的可多次使用的多通道电极装置的结构示意图;1 is a schematic structural view of a multi-channel electrode device that can be used multiple times in Embodiment 1 of the present invention;
图2a是本发明实施例1的可多次使用的多通道电极装置中采集端的结构示意图;Fig. 2a is a schematic structural view of the collecting end in the multiple-usable multi-channel electrode device according to Embodiment 1 of the present invention;
图2b是本发明实施例1的可多次使用的多通道电极装置中采集端的结构示意图;Fig. 2b is a schematic structural diagram of the collecting end in the multiple-usable multi-channel electrode device according to Embodiment 1 of the present invention;
图3是本发明实施例1的可多次使用的多通道电极装置中电极接口的结构示意图;3 is a schematic structural view of the electrode interface in the multi-channel electrode device that can be used multiple times in Embodiment 1 of the present invention;
图4a是本发明实施例1的可多次使用的多通道电极装置中绝缘管图;Fig. 4a is a diagram of insulating tubes in the multiple-usable multi-channel electrode device according to Embodiment 1 of the present invention;
图4b是本发明实施例1的可多次使用的多通道电极装置中卷轴的结构示意图;Fig. 4b is a schematic structural view of the reel in the reusable multi-channel electrode device according to Embodiment 1 of the present invention;
图5是本发明实施例1的可多次使用的多通道电极装置中支撑部的结构示意图;5 is a schematic structural view of the supporting part of the multiple-usable multi-channel electrode device according to Embodiment 1 of the present invention;
图6是本发明实施例2的可多次使用的多通道电极装置中采集端的结构示意图。Fig. 6 is a schematic structural view of the collection end of the multiple-usable multi-channel electrode device according to
【具体实施方式】【Detailed ways】
为了使本发明的目的、技术方案及优点更加清楚明白,下面结合附图和具体实施例对本发明作进一步详细说明。应当理解,此处所描述的具体实施例仅仅用以解释本发明,并不用于限定本发明。In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.
本发明实施例提供了一种可多次使用的多通道电极装置,包括:An embodiment of the present invention provides a multi-channel electrode device that can be used multiple times, including:
电极主体,包括至少一个金属丝电极,所述金属丝电极的末端形成一用于采集生理电信号的采集端;The electrode body includes at least one wire electrode, and the end of the wire electrode forms a collection end for collecting physiological electrical signals;
与所述金属丝电极连接的电极接口;an electrode interface connected to the wire electrode;
连接所述电极接口、用于容纳所述金属丝电极的电极传动单元,所述采集端穿过所述电极传动单元;connecting the electrode interface and an electrode transmission unit for accommodating the wire electrode, and the collection end passes through the electrode transmission unit;
用于支撑所述电极接口的支撑部,所述采集端固定于所述支撑部。The supporting part is used to support the electrode interface, and the collecting end is fixed on the supporting part.
具体地,本发明实施例的可多次使用的多通道电极装置含有电极传动单元,用于容纳金属丝电极,在采集端无法使用后,可对其进行截取,将容纳于电极传动单元的金属丝电极抽出,形成新的采集端,为可多次使用电极,降低成本;本发明实施例的可多次使用的多通道电极装置使用的是金属丝电极,通道数和记录位点可以根据需要进行选择,适用范围广;本发明实施例的可多次使用的多通道电极装置制备工艺简单,耗时少。Specifically, the multi-channel electrode device that can be used repeatedly in the embodiment of the present invention includes an electrode transmission unit for accommodating the wire electrode. The wire electrode is pulled out to form a new collection terminal, so that the electrode can be used multiple times to reduce costs; the multi-channel electrode device that can be used multiple times in the embodiment of the present invention uses a wire electrode, and the number of channels and recording sites can be adjusted according to the needs. The selection has a wide range of applications; the multi-channel electrode device that can be used multiple times in the embodiment of the present invention has a simple manufacturing process and less time-consuming.
实施例1Example 1
本发明实施例1提供了一种可多次使用的多通道电极装置,如图1所示,该装置包括:电极主体1、电极接口2、电极传动单元3、支撑部4、光纤5和光纤接口6。Embodiment 1 of the present invention provides a multi-channel electrode device that can be used multiple times. As shown in FIG. interface6.
请同时参阅图1和图3所示,电极主体1包括8个金属丝电极11,8个金属丝电极11的末端形成采集端1a,用于采集生理电信号;金属丝电极11与电极接口2连接,在本实施例中,电极接口2为长方体型,电极接口2为多通道接口,可以是10通道、20通道或36通道等,上述通道数为采集电极通道数与接地通道、参考通道的总数。Please refer to Fig. 1 and Fig. 3 at the same time, the electrode body 1 includes 8
请同时参阅图1、图4a、图4b所示,电极传动单元3连接电极接口2、金属丝电极11容纳于电极传动单元3的空腔内,采集端1a穿过电极传动单元3,设于支撑部4上,支撑部4用于支撑电极接口2,电极传动单元3具有用于容纳金属丝电极11的空腔,空腔内设有卷轴31,绝缘管12部分包裹金属丝电极11,金属丝电极11的两端裸露于绝缘管12外,绝缘管12缠绕于卷轴31。卷轴31可以是玻璃或有机聚合物制成的光滑的圆形卷轴,将绝缘管12缠绕在卷轴31上,在采集端1a无法使用时,只需将卷轴31转动放出一段绝缘管线,取下一截套于金属丝电极上的绝缘管,将新露出的金属丝抽出作为新的采集端即可使用。在本实施例中,绝缘管12由非金属柔性材料制成,非金属柔性材料包括硅橡胶或聚酰亚胺,硅橡胶和聚酰亚胺均为对人体无伤害的有机材料,导电率低且柔性较好,可弯曲形成多种形状。Please refer to Fig. 1, Fig. 4a and Fig. 4b at the same time, the electrode transmission unit 3 is connected to the
请参阅图5所示,支撑部4呈竖折状,由一长条形主体经两次弯折形成,长条形主体包括位于中间的第三主体43及分别位于第三主体43上下两侧的第一主体41和第二主体42,长条形主体相对于第三主体43的中心点呈中心对称。电极接口2设于第三主体43上,采集端1a平行设于第二主体42。支撑部4为刚性,坚硬,能维持一定固定形状,可以是铜、不锈钢等金属材料制成,也可以是玻璃、陶瓷或者硬质塑料。Please refer to FIG. 5 , the supporting part 4 is vertically folded, and is formed by bending twice a strip-shaped main body. The first
在本实施例的一个较佳方案中,如图1、图2a和图2b所示,该装置还包括光纤5,光纤5的一端与光纤接口6连接,光纤的另一端与采集端1a配置为可拆卸式连接结构,8个金属丝电极11均匀环绕于光纤5周围,采集端1a的金属丝电极11下端伸出长于光纤5,在使用本方案的装置时,可通过光纤5传输光刺激的光照,光纤5发出的光照可覆盖采集端1a邻近的神经组织,采集端1a采集受到光刺激的神经组织的局部电位和放电的电流等电信号。In a preferred solution of this embodiment, as shown in Figure 1, Figure 2a and Figure 2b, the device also includes an
光纤5与采集端1a可通过聚乙二醇封装连接,在不需使用光纤5时,将聚乙二醇溶解,将光纤5拆除。The
进一步地,在本实施例中,金属丝电极11的横截面直径为5-50μm。Further, in this embodiment, the cross-sectional diameter of the
进一步地,在本实施例中,光纤5横截面的直径为50-300μm。Further, in this embodiment, the diameter of the cross section of the
本实施例中,可多次使用的多通道电极装置含有电极传动单元,用于容纳金属丝电极,在采集端无法使用后,可对其进行截取,将容纳于电极传动单元的金属丝电极抽出,形成新的采集端,为可多次使用电极,降低成本;多通道电极装置使用的是金属丝电极,通道数和记录位点可以根据需要进行选择,适用范围广;多通道电极装置制备工艺简单,耗时少。In this embodiment, the multi-channel electrode device that can be used multiple times includes an electrode transmission unit for accommodating the wire electrode. After the collection end cannot be used, it can be intercepted, and the wire electrode accommodated in the electrode transmission unit can be pulled out. , to form a new collection terminal, in order to use the electrode multiple times and reduce the cost; the multi-channel electrode device uses a wire electrode, the number of channels and recording sites can be selected according to the needs, and the application range is wide; the preparation process of the multi-channel electrode device Simple and less time consuming.
实施例2Example 2
本发明实施例2提供了一种可多次使用的多通道电极装置。为了便于描述,仅示出了与本发明实施例1不同的部分,与实施例1相同的部分不一一赘述。如图6所示,本实施例中,采集端1a中的金属丝电极11上套设有电极管13,电极管13的排列方式可以根据需求不同而变化,如2x4、4x4等排布的矩阵,或圆形,或以光纤为中心等,通过电极管13的排布可对金属丝电极11进行排布。在本实施例中,电极管13由非金属柔性材料制成,非金属柔性材料包括硅橡胶或聚酰亚胺,硅橡胶和聚酰亚胺均为对人体无伤害的有机材料,导电率低且柔性较好,可弯曲形成多种形状。
另外,在本实施例中,金属丝电极11的数量可以为1,2或4,即电极主体为单电极、双电极或四电极。In addition, in this embodiment, the number of
以上所述本发明的具体实施方式,并不构成对本发明保护范围的限定。任何根据本发明的技术构思所做出的各种其他相应的改变与变形,均应包含在本发明权利要求的保护范围内。The specific embodiments of the present invention described above do not constitute a limitation to the protection scope of the present invention. Any other corresponding changes and modifications made according to the technical concept of the present invention shall be included in the protection scope of the claims of the present invention.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310462756.3ACN103479345B (en) | 2013-09-30 | 2013-09-30 | Reused multi-channel electrode device |
| Application Number | Priority Date | Filing Date | Title |
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| CN201310462756.3ACN103479345B (en) | 2013-09-30 | 2013-09-30 | Reused multi-channel electrode device |
| Publication Number | Publication Date |
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| CN103479345Atrue CN103479345A (en) | 2014-01-01 |
| CN103479345B CN103479345B (en) | 2015-07-29 |
| Application Number | Title | Priority Date | Filing Date |
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| CN201310462756.3AActiveCN103479345B (en) | 2013-09-30 | 2013-09-30 | Reused multi-channel electrode device |
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