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CN103442600B - Smokeless tobacco composition and the method for preparing smokeless tobacco composition lozenge - Google Patents

Smokeless tobacco composition and the method for preparing smokeless tobacco composition lozengeDownload PDF

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CN103442600B
CN103442600BCN201180062926.8ACN201180062926ACN103442600BCN 103442600 BCN103442600 BCN 103442600BCN 201180062926 ACN201180062926 ACN 201180062926ACN 103442600 BCN103442600 BCN 103442600B
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smokeless tobacco
tobacco
composition
tobacco composition
parts
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CN103442600A (en
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丹尼尔·韦尔丹·坎特雷尔
罗伯特·弗兰克·布廷
托马斯·欣克迈耶尔
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RJ Reynolds Tobacco Co
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Abstract

Translated fromChinese

本发明提供了一种被构造成用于插入使用者嘴中的无烟烟草组合物。所述无烟烟草组合物包括烟草材料和多糖填充剂组分，诸如聚葡萄糖。还提供了一种用于制备无烟烟草组合物锭剂的方法，所述锭剂被构造成用于插入使用者嘴中。所述方法包括：将烟草材料与粘合剂和多糖填充剂组分混合，以形成无烟烟草混合物，注射模塑所述无烟烟草混合物，和冷却所述无烟烟草混合物，以形成固化的无烟烟草组合物锭剂。所述混合步骤可以包括：形成烟草、填充剂和粘合剂组分的干燥的掺合物，和将所述干燥的掺合物与粘稠的液体组分合并。所述注射模塑锭剂可以提供可溶解的且可轻轻咀嚼的产品。The present invention provides a smokeless tobacco composition configured for insertion into the mouth of a user. The smokeless tobacco composition includes tobacco material and a polysaccharide filler component, such as polydextrose. Also provided is a method for preparing a lozenge of a smokeless tobacco composition configured for insertion into the mouth of a user. The method comprises: mixing tobacco material with a binder and a polysaccharide filler component to form a smokeless tobacco blend, injection molding the smokeless tobacco blend, and cooling the smokeless tobacco blend to form a cured Smokeless tobacco composition lozenges. The mixing step may include forming a dry blend of tobacco, filler, and binder components, and combining the dry blend with a viscous liquid component. The injection molded lozenges can provide a dissolvable and gently chewable product.

Description

Translated fromChinese
无烟烟草组合物和用于制备无烟烟草组合物锭剂的方法Smokeless tobacco composition and method for preparing lozenges of smokeless tobacco composition

技术领域technical field

本公开内容涉及从烟草制成或衍生出的产品，或者所述产品以其它方式包含烟草，且意图用于人消费。具体地，本公开内容涉及意图以无烟形式使用的包含烟草的组合物或制剂。The present disclosure relates to products made or derived from, or otherwise incorporating tobacco, intended for human consumption. In particular, the present disclosure relates to tobacco-containing compositions or formulations intended for use in a smoke-free form.

背景技术Background technique

香烟、雪茄和烟丝是处于不同形式的使用烟草的常见吸烟制品。如下使用这些吸烟制品：加热或燃烧烟草，以产生可被吸烟者吸入的气溶胶（如烟）。还可以以所谓“无烟”形式享用烟草。通过将一些形式的经过处理的烟草或含烟草制剂插入使用者嘴中，使用特别流行的无烟烟草产品。参见例如，在下述文献中阐述的无烟烟草制剂类型、成分和加工方法： Schwartz的美国专利号1,376,586；Levi的美国专利号3,696,917；Pittman 等人的美国专利号4,513,756；Sensabaugh,Jr.等人的美国专利号 4,528,993；Story等人的美国专利号4,624,269；Tibbetts的美国专利号 4,991,599；Townsend的美国专利号4,987,907；Sprinkle,III等人的美国专利号5,092,352；White等人的美国专利号5,387,416；Williams的美国专利号6,668,839；Williams的美国专利号6,834,654；Atchley等人的美国专利号6,953,040；Atchley等人的美国专利号7,032,601；和Atchley 等人的美国专利号7,694,686；Williams的美国专利公开号2004/0020503； Quinter等人的美国专利公开号2005/0115580；Strickland等人的美国专利公开号2005/0244521；Strickland等人的美国专利公开号 2006/0191548；Holton,Jr.等人的美国专利公开号2007/0062549；Holton, Jr.等人的美国专利公开号2007/0186941；Strickland等人的美国专利公开号2007/0186942；Dube等人的美国专利公开号2008/0029110；Robinson 等人的美国专利公开号2008/0029116；Mua等人的美国专利公开号 2008/0029117；Robinson等人的美国专利公开号2008/0173317；Engstrom 等人的美国专利公开号2008/0196730；Neilsen等人的美国专利公开号2008/0209586；Crawford等人的美国专利公开号2008/0305216；Essen等人的美国专利公开号2009/0065013；Kumar等人的美国专利公开号 2009/0293889；Gao等人的美国专利公开号2010/0291245；和Mua等人的美国专利公开号2011/0139164；Arnarp等人的PCT WO04/095959；和 Atchley的WO2010/132444A2，它们中的每一篇通过引用并入本文。已经投放市场的示例性的无烟烟草产品包括被称作下述名称的那些：R.J. Reynolds TobaccoCompany的CAMEL Snus、CAMEL Orbs、CAMEL Strips 和CAMEL Sticks；American SnuffCompany,LLC的GRIZZLY潮湿烟草、 KODIAK潮湿烟草、LEVI GARRETT松散烟草和TAYLOR'SPRIDE松散烟草； Swisher International,Inc.的KAYAK潮湿鼻烟和CHATTANOOGA CHEW嚼烟；Pinkerton Tobacco Co.LP的REDMAN嚼烟；U.S.Smokeless Tobacco Company的COPENHAGEN潮湿烟草、COPENHAGEN Pouches、SKOAL Bandits、 SKOAL Pouches、RED SEAL长条带和REVEL Mint Tobacco Packs；以及Philip Morris USA.的MARLBORO Snus和Taboka。Cigarettes, cigars, and tobacco are common smoking articles that use tobacco in different forms. These smoking articles are used by heating or burning tobacco to produce an aerosol (eg, smoke) that can be inhaled by the smoker. Tobacco can also be enjoyed in so-called "smoke-free" forms. Smokeless tobacco products, which are particularly popular, are used by inserting some form of processed tobacco or tobacco-containing preparations into the user's mouth. See, for example, smokeless tobacco formulation types, ingredients, and processing methods described in: U.S. Patent No. 1,376,586 to Schwartz; U.S. Patent No. 3,696,917 to Levi; U.S. Patent No. 4,513,756 to Pittman et al.; U.S. Patent No. 4,513,756 to Pittman et al.; US Patent No. 4,528,993; US Patent No. 4,624,269 to Story et al.; US Patent No. 4,991,599 to Tibbetts; US Patent No. 4,987,907 to Townsend; US Patent No. 5,092,352 to Sprinkle, III et al.; U.S. Patent No. 6,668,839; U.S. Patent No. 6,834,654 to Williams; U.S. Patent No. 6,953,040 to Atchley et al; U.S. Patent No. 7,032,601 to Atchley et al; and U.S. Patent No. 7,694,686 to Atchley et al; U.S. Patent Publication No. 2005/0115580 to Quinter et al; U.S. Patent Publication No. 2005/0244521 to Strickland et al; U.S. Patent Publication No. 2006/0191548 to Strickland et al; U.S. Patent Publication No. 2007/0062549 to Holton, Jr. et al U.S. Patent Publication No. 2007/0186941 to Holton, Jr. et al.; U.S. Patent Publication No. 2007/0186942 to Strickland et al.; U.S. Patent Publication No. 2008/0029110 to Dube et al.; 0029116; U.S. Patent Publication No. 2008/0029117 to Mua et al; U.S. Patent Publication No. 2008/0173317 to Robinson et al; U.S. Patent Publication No. 2008/0196730 to Engstrom et al; U.S. Patent Publication No. 2008/0209586 to Neilsen et al U.S. Patent Publication No. 2008/0305216 to Crawford et al.; U.S. Patent Publication No. 2009/0065013 to Essen et al.; U.S. Patent Publication No. 2009/0293889 to Kumar et al.; U.S. Patent Publication No. 2010/0291245 to Gao et al.; US Patent Publication No. 2011/0139164 to et al.; PCT WO04/095959 to Arnarp et al.; and WO2010/132444A2 to Atchley, each of which is incorporated herein by reference. Exemplary smokeless tobacco products that have been marketed include those known by the following names: CAMEL Snus, CAMEL Orbs, CAMEL Strips and CAMEL Sticks of the R.J. Reynolds Tobacco Company; GRIZZLY Moist Tobacco, KODIAK Moist Tobacco of the American Snuff Company, LLC; LEVI GARRETT loose tobacco and TAYLOR'SPRIDE loose tobacco; KAYAK moist snuff and CHATTANOOGA CHEW chewing tobacco from Swisher International, Inc.; REDMAN chewing tobacco from Pinkerton Tobacco Co.LP; COPENHAGEN moist tobacco, COPENHAGEN Pouches, SKOAL Bandits from U.S. Smokeless Tobacco Company , SKOAL Pouches, RED SEAL Long Strips, and REVEL Mint Tobacco Packs; and MARLBORO Snus and Taboka from Philip Morris USA.

希望提供一种令人愉悦形式的烟草产品诸如无烟烟草产品，以及提供制备适用于无烟烟草产品中的含烟草组合物的方法。It would be desirable to provide a pleasurable form of tobacco products, such as smokeless tobacco products, and to provide methods of preparing tobacco-containing compositions suitable for use in smokeless tobacco products.

发明内容Contents of the invention

本公开内容涉及一种被构造成用于插入使用者嘴中的可溶解的无烟烟草锭剂产品和用于制备适合用于无烟烟草产品中的无烟烟草组合物的方法。本公开内容的无烟烟草组合物利用多糖填充剂组分来提供注射模塑锭剂形式的具有可轻轻咀嚼特性的可溶解的无烟烟草产品。在一个实施方案中，所述无烟烟草产品是呈具有烟草材料（例如，微粒状烟草材料）和多糖填充剂组分的固体物体的形式。所述无烟烟草组合物优选地包括多糖填充剂组分和呈颗粒或微粒形式或者呈液体或脱水烟草提取物形式的烟草，且可以包括其它成分，诸如甜味剂、粘合剂、乳化剂、额外的填充剂、矫味剂和崩解助剂。根据一个方面，所述烟草材料包括烟草颗粒，所述烟草颗粒具有小于约100微米、小于约75微米、通常小于约50微米的平均粒度，且最经常具有约25微米的平均粒度。The present disclosure relates to a dissolvable smokeless tobacco pastille product configured for insertion into a user's mouth and a method for preparing a smokeless tobacco composition suitable for use in a smokeless tobacco product. The smokeless tobacco composition of the present disclosure utilizes a polysaccharide filler component to provide a dissolvable smokeless tobacco product with lightly chewable properties in the form of an injection molded lozenge. In one embodiment, the smokeless tobacco product is in the form of a solid object having tobacco material (eg, particulate tobacco material) and a polysaccharide filler component. The smokeless tobacco composition preferably comprises a polysaccharide filler component and tobacco in granular or particulate form or in the form of a liquid or dehydrated tobacco extract, and may include other ingredients such as sweeteners, binders, emulsifiers , additional fillers, flavoring agents and disintegration aids. According to one aspect, the tobacco material comprises tobacco particles having an average particle size of less than about 100 microns, less than about 75 microns, usually less than about 50 microns, and most often about 25 microns.

在一个方面，本公开内容提供了一种无烟烟草锭剂产品，其被构造成用于插入所述产品的使用者嘴中，所述无烟烟草锭剂产品包含烟草材料和多糖填充剂组分。适用于提供根据本公开内容的无烟烟草锭剂产品的多糖填充剂组分包括聚葡萄糖、麦芽糊精、普鲁兰多糖、及它们的混合物。In one aspect, the present disclosure provides a smokeless tobacco pastille product configured for insertion into the mouth of a user of the product, the smokeless tobacco pastille product comprising a tobacco material and a polysaccharide filler group point. Polysaccharide filler components suitable for use in providing smokeless tobacco lozenge products according to the present disclosure include polydextrose, maltodextrin, pullulan, and mixtures thereof.

所述无烟烟草组合物可以另外包括一种或多种添加剂，诸如调味剂、额外的填充剂、粘合剂、乳化剂、湿润剂、糖浆、崩解助剂、及它们的混合物。本发明的无烟烟草产品的某些实施方案包括粘合剂（例如，阿拉伯树胶或其它水溶性的树胶）、湿润剂（例如，玉米糖浆）、糖醇（例如，山梨醇）、人工甜味剂（例如，三氯蔗糖）、调味剂、盐（例如，氯化钠）或它们的组合。The smokeless tobacco composition may additionally include one or more additives such as flavoring agents, additional fillers, binders, emulsifiers, humectants, syrups, disintegration aids, and mixtures thereof. Certain embodiments of the smokeless tobacco products of the present invention include binders (e.g., gum arabic or other water-soluble gums), humectants (e.g., corn syrup), sugar alcohols (e.g., sorbitol), artificially sweetened agents (e.g., sucralose), flavoring agents, salt (e.g., sodium chloride), or combinations thereof.

尽管各种组分的相对量可以变化，本发明的无烟烟草组合物通常包含约10重量%至约25重量%的多糖填充剂组分（按干重计）。在一个实施方案中，所述无烟烟草组合物包括：至少约20干重%的烟草材料，基于所述组合物的总重量；至少约10干重%的多糖填充剂组分；至少约10干重%的至少一种粘合剂；至少约20干重%的至少一种湿润剂；至少约1干重%的至少一种乳化剂；至少约0.1干重%的至少一种甜味剂；和至少约0.5干重%的至少一种调味剂。Although the relative amounts of the various components may vary, the smokeless tobacco compositions of the present invention generally comprise from about 10% to about 25% by weight of the polysaccharide filler component (by dry weight). In one embodiment, the smokeless tobacco composition comprises: at least about 20 dry weight percent tobacco material, based on the total weight of the composition; at least about 10 dry weight percent polysaccharide filler component; at least about 10 Dry weight % of at least one binder; at least about 20 dry weight % of at least one wetting agent; at least about 1 dry weight % of at least one emulsifier; at least about 0.1 dry weight % of at least one sweetener and at least about 0.5% by dry weight of at least one flavoring agent.

在另一个方面，本公开内容提供了一种用于制备无烟烟草组合物锭剂的方法，所述锭剂被构造成用于插入使用者嘴中，所述方法包括：将烟草材料（例如，微粒状烟草材料）与粘合剂和多糖填充剂组分混合以形成无烟烟草混合物；注射模塑所述无烟烟草混合物（例如，通过使用至少约 75,000kPa或至少约100,000kPa的挤压力，压制所述无烟烟草混合物）；和冷却所述无烟烟草混合物，以形成固化的无烟烟草组合物锭剂（例如，冷却至约20℃至约25℃的温度）。In another aspect, the present disclosure provides a method for preparing a lozenge of a smokeless tobacco composition configured for insertion into a user's mouth, the method comprising: introducing a tobacco material such as , particulate tobacco material) mixed with binder and polysaccharide filler components to form a smokeless tobacco blend; injection molding said smokeless tobacco blend (e.g., by using an extrusion press of at least about 75,000 kPa or at least about 100,000 kPa force, compressing the smokeless tobacco mixture); and cooling the smokeless tobacco mixture to form a cured smokeless tobacco composition pastille (eg, cooling to a temperature of about 20°C to about 25°C).

在一个实施方案中，所述混合步骤包括：形成干燥的掺合物，所述掺合物包含烟草材料、粘合剂和多糖填充剂组分的混合物，和将所述干燥的掺合物与液体组分合并，以形成所述无烟烟草混合物。就干燥的掺合物的所有组分而言，有利的是，具有相对较低的含水量（例如，小于约5重量% 的水分），且具有相对均匀的粒度（例如，小于约50微米）。如果需要的话，所述干燥的掺合物可以另外包含盐、甜味剂或它们的组合。所述液体组分在室温或者当被加热至高温（例如，约40℃至约150℃）时通常是非常粘稠的液体，且通常含有一种或多种湿润剂、乳化剂、胶凝剂、糖浆或它们的组合。In one embodiment, the step of mixing includes forming a dry blend comprising a mixture of tobacco material, binder and polysaccharide filler components, and combining the dry blend with The liquid components are combined to form the smokeless tobacco blend. It is advantageous for all components of the dry blend to have a relatively low moisture content (e.g., less than about 5% moisture by weight) and a relatively uniform particle size (e.g., less than about 50 microns) . The dry blend may additionally contain salt, sweetener, or combinations thereof, if desired. The liquid components are typically very viscous liquids at room temperature or when heated to elevated temperatures (eg, from about 40°C to about 150°C), and typically contain one or more wetting agents, emulsifiers, gelling agents , syrup or a combination thereof.

在某些实施方案中，所述方法可以包括：在混合步骤之前，将添加剂加入烟草材料中。示例性的添加剂包括调味剂、乳化剂、崩解助剂、湿润剂、及它们的混合物。In certain embodiments, the method may include adding the additive to the tobacco material prior to the mixing step. Exemplary additives include flavoring agents, emulsifiers, disintegration aids, wetting agents, and mixtures thereof.

在某些实施方案中，在注射模塑方法之前，将所述无烟烟草混合物挤出成挤出形式，然后进行研磨，以便产生粉末颗粒。可以将挤出的研磨的组合物装载进注射模具中，用于以后模塑成终产品形式。In certain embodiments, prior to the injection molding process, the smokeless tobacco blend is extruded into extruded form and then ground to produce powder particles. The extruded milled composition can be loaded into an injection mold for later molding into the final product form.

本公开内容的方面因而提供了如本文别处详述的优点。Aspects of the disclosure thus provide advantages as detailed elsewhere herein.

具体实施方式detailed description

现在将在下文中更全面地描述本公开内容。本公开内容可以以许多不同的形式具体化，且不应解释为限于本文阐述的方面；相反，提供了这些方面，使得本公开内容将满足适用的法律要求。如在本说明书和权利要求中所使用的，单数形式“一个”、“一种”和“所述”包括复数指示物，除非上下文另外清楚地指明。The present disclosure will now be described more fully hereinafter. The present disclosure may be embodied in many different forms and should not be construed as limited to the aspects set forth herein; rather, these aspects are provided so that this disclosure will satisfy applicable legal requirements. As used in this specification and claims, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise.

本发明提供了一种适合用于口服使用的无烟烟草组合物。所述无烟烟草组合物通常包括烟草材料制剂和一种或多种其它组分，它们组合以形成可溶解的且可轻轻咀嚼的无烟烟草锭剂产品。本文使用的术语“锭剂”表示如下制成的可溶解的口服产品：固化液体或凝胶组合物（诸如包括胶凝剂或粘合剂的组合物），使得终产品是硬化的固体凝胶。本文使用的术语“溶解”和“可溶解的”表示具有水溶性组分的组合物，所述水溶性组分与口腔中的水分相互作用并进入溶液中，由此造成产品的逐渐消费。在某些实施方案中，本发明的产品的特征在于足够的粘着性，以耐受在口腔中的轻轻咀嚼动作，而不会迅速地崩解。本发明的产品通常不会表现出如在常规口香糖中发现的可高度变形的咀嚼特性。The present invention provides a smokeless tobacco composition suitable for oral use. The smokeless tobacco composition generally includes a formulation of tobacco material and one or more other components that combine to form a dissolvable and lightly chewable smokeless tobacco lozenge product. The term "lozenge" as used herein means a dissolvable oral product made by solidifying a liquid or gel composition, such as a composition including a gelling agent or binder, such that the final product is a hardened solid gel . As used herein, the terms "dissolved" and "dissolvable" refer to compositions having water-soluble components that interact with the moisture in the oral cavity and go into solution, thereby resulting in gradual consumption of the product. In certain embodiments, the products of the present invention are characterized by sufficient cohesiveness to withstand a gentle chewing action in the oral cavity without rapidly disintegrating. The products of the present invention generally do not exhibit the highly deformable chewing properties found in conventional chewing gum.

在某些实施方案中，本发明的产品的有利器官感觉特性可以归因于多糖填充剂组分的存在。这些碳水化合物材料通常包含一种或多种含有多个单糖单元的多糖。示例性的单糖单元包括木糖、核糖、果糖、葡萄糖（例如，右旋糖）、麦芽糖和甘露糖。所述多糖的数量平均分子量可以变化，但是通常为约1,000Da至约20,000Da，更经常为约2,000Da至约10,000Da。示例性的多糖包括聚葡萄糖、麦芽糊精和普鲁兰多糖。麦芽糊精的一种来源是得自Grain Processing Corporation的MALTRIN M100。In certain embodiments, the favorable organoleptic properties of the products of the present invention can be attributed to the presence of a polysaccharide bulking component. These carbohydrate materials generally comprise one or more polysaccharides containing multiple monosaccharide units. Exemplary monosaccharide units include xylose, ribose, fructose, glucose (eg, dextrose), maltose, and mannose. The number average molecular weight of the polysaccharide can vary, but is generally from about 1,000 Da to about 20,000 Da, more often from about 2,000 Da to about 10,000 Da. Exemplary polysaccharides include polydextrose, maltodextrin, and pullulan. One source of maltodextrin is MALTRIN M100 from Grain Processing Corporation.

聚葡萄糖主要由这样的聚合物组成：所述聚合物包含具有小量多元醇（例如，山梨醇）的葡萄糖单元和可食用酸（例如，柠檬酸）。聚葡萄糖通常通过酸催化的葡萄糖单元的聚合来制备，如果需要的话，所述聚合使用多元醇作为链终止剂。示例性的可食用酸包括各种无机酸和羧酸。例如，可以使用在Borden等人的美国专利号5,601,863（其通过引用并入本文）中阐述的方法来制备聚葡萄糖。聚葡萄糖可以被描述为可溶性的纤维填充剂，且聚葡萄糖也可以表现出湿润剂样性能。示例性的聚葡萄糖来源包括： LITESSE聚葡萄糖（可得自Danisco A/S）、STA-LITE聚葡萄糖（可得自Tate &Lyle Ingredients Americas,Inc.）和TRIMCAL聚葡萄糖（可得自C and H Ingredients Ltd）。在一个实施方案中，将所述聚葡萄糖与第二多糖组分（诸如麦芽糊精或普鲁兰多糖）组合。Polydextrose mainly consists of polymers comprising glucose units with small amounts of polyols (eg, sorbitol) and edible acids (eg, citric acid). Polydextrose is usually prepared by acid-catalyzed polymerization of glucose units, using polyols as chain terminators, if desired. Exemplary edible acids include various mineral acids and carboxylic acids. For example, polydextrose can be prepared using the methods set forth in US Patent No. 5,601,863 to Borden et al., which is incorporated herein by reference. Polydextrose can be described as a soluble fiber bulking agent, and polydextrose can also exhibit humectant-like properties. Exemplary sources of polydextrose include: LITESSE polydextrose (available from Danisco A/S), STA-LITE polydextrose (available from Tate & Lyle Ingredients Americas, Inc.), and TRIMCAL polydextrose (available from C and H Ingredients Ltd). In one embodiment, the polydextrose is combined with a second polysaccharide component such as maltodextrin or pullulan.

优选地以研磨、粒化、细微粒或粉末形式提供用于制造无烟烟草产品的多糖填充剂组分。优选地，以具有小于约100微米、更优选小于约50微米的平均粒度的块或片的形式使用多糖填充剂组分。The polysaccharide filler component used in the manufacture of smokeless tobacco products is preferably provided in ground, granulated, fine particle or powder form. Preferably, the polysaccharide filler component is used in the form of pieces or flakes having an average particle size of less than about 100 microns, more preferably less than about 50 microns.

在所述无烟烟草组合物内的多糖填充剂组分的相对量可以变化。优选地，基于组合物的干重，在所述无烟烟草组合物内的多糖填充剂组分的量是至少约5%、或至少约10%、或至少约15%。一个示例性的重量范围是约5 重量%至约50重量%，更经常约10重量%至约25重量%。The relative amount of the polysaccharide filler component within the smokeless tobacco composition can vary. Preferably, the amount of polysaccharide filler component in the smokeless tobacco composition is at least about 5%, or at least about 10%, or at least about 15%, based on the dry weight of the composition. An exemplary weight range is about 5% to about 50% by weight, more often about 10% to about 25% by weight.

在与烟草材料制剂混合之前，多糖填充剂组分的含水量可以变化。最优选地，多糖填充剂组分的含水量是小于约10重量%，且可以是小于约5%，且经常是小于约2.5重量%。The moisture content of the polysaccharide filler component may be varied prior to mixing with the tobacco material formulation. Most preferably, the moisture content of the polysaccharide bulking component is less than about 10% by weight, and may be less than about 5%, and often is less than about 2.5% by weight.

本发明的产品包含某种形式的烟草属种（Nicotiana species）植物，并最优选地，那些组合物或产品包含某种形式的烟草。烟草属种的选择可以变化；且具体地，一种或多种烟草的类型的选择可以变化。可以采用的烟草包括：烟道烘烤的烟草或弗吉尼亚（例如，K326）、白肋烟草、晒干的烟草（例如，印度Kurnool和Oriental烟草，包括Katerini、Prelip、Komotini、Xanthi和Yambol烟草）、马里兰烟草、深色烟草、深色明火烟草、深色风干烟草（例如，Passanda、Cubano、Jatin和Bezuki烟草）、轻风风干的烟草（例如，North Wisconsin和Galpao烟草）、印度风干的烟草、Red Russian烟草和Rustica烟草以及各种其它罕见的或专用的烟草。在Tobacco Production,Chemistry and Technology,Davis等人（编）（1999）（其通过引用并入本文）中，阐述了不同类型的烟草、栽培实践和收获实践的描述。来自烟草种的各种代表性的其它植物类型参见： Goodspeed,The Genus Nicotiana,（ChonicaBotanica）（1954）； Sensabaugh,Jr.等人的美国专利号4,660,577；White等人的美国专利号 5,387,416，和Lawson等人的美国专利号7,025,066；Lawrence,Jr.的美国专利申请公开号2006/0037623，和Marshall等人的美国专利申请公开号2008/0245377；它们中的每一篇通过引用并入本文。示例性的烟草种包括：红花烟草（N.tabacum）、黄花烟草（N.rustica）、花烟草（N.alata）、 N.arentsii、N.excelsior、福尔吉特氏烟草（N.forgetiana）、粉蓝烟草（N.glauca）、粘烟草（N.glutinosa）、哥西氏烟草（N.gossei）、卡瓦卡米氏烟草（N.kawakamii）、奈特氏烟草（N.knightiana）、朗氏烟草（N.langsdorffi）、耳状烟草（N.otophora）、赛特氏烟草（N.setchelli）、林烟草（N.sylvestris）、绒毛烟草（N.tomentosa）、绒毛状烟草（N.tomentosiformis）、波叶烟草（N.undulata）、花烟草（N.xsanderae）、非洲烟草（N.africana、）、抱茎烟草（N. amplexicaulis）、贝纳末特氏烟草（N.benavidesii）、博内里烟草（N. bonariensis）、迪勃纳氏烟草（N.debneyi）、长苞烟草（N.longiflora）、海滨烟草（N.maritina）、特大管烟草（N.megalosiphon）、西方烟草（N.occidentalis）、圆锥烟草（N.paniculata）、蓝茉莉叶烟草（N. plumbaginifolia）、雷蒙德氏烟草（N.raimondii）、莲坐叶烟草（N. rosulata）、拟似烟草（N.simulans）、斯托克同氏烟草（N.stocktonii）、香甜烟草（N.suaveolens）、荫生烟草（N.umbratica）、颤毛烟草（N.velutina）、芹叶烟草（N.wigandioides）、无茎烟草（N.acaulis）、渐尖叶烟草（N.acuminata）、渐狭叶烟草（N.attenuata）、本赛姆氏烟草（N.benthamiana）、洞生烟草（N.cavicola）、克里夫兰氏烟草（N.clevelandii）、心叶烟草（N.cordifolia）、伞床烟草（N.corymbosa）、香烟草（N.fragrans）、古特斯比氏烟草（N. goodspeedii）、狭叶烟草（N.linearis）、摩西氏烟草（N.miersii）、裸茎烟草（N.nudicaulis）、欧布特斯烟草（N.obtusifolia）、蓟马烟Hersperis亚种（N.occidentalis subsp.Hersperis）、少花烟草（N.pauciflora）、矮牵牛状烟草（N.petunioides）、夸德瑞伍氏烟草（N.quadrivalvis）、残波烟草（N.repanda）、圆叶烟草（N.rotundifolia）、茄子烟草（N.solanifolia）和斯佩格茨烟草（N.spegazzinii）。The products of the invention comprise some form of a plant of the Nicotiana species, and most preferably those compositions or products comprise some form of tobacco. The selection of Nicotiana species can vary; and in particular, the selection of one or more types of tobacco can vary. Tobacco that can be used includes: flue-cured or Virginia (e.g., K326), burley, sun-dried tobacco (e.g., Indian Kurnool and Oriental tobaccos, including Katerini, Prelip, Komotini, Xanthi, and Yambol tobaccos), Maryland tobacco, dark tobacco, dark open flame tobacco, dark air-cured tobacco (for example, Passanda, Cubano, Jatin, and Bezuki tobacco), light air-cured tobacco (for example, North Wisconsin and Galpao tobacco), Indian air-cured tobacco, Red Russian and Rustica tobaccos and various other exotic or specialty tobaccos. In Tobacco Production, Chemistry and Technology, Davis et al. (eds.) (1999), which is incorporated herein by reference, descriptions of the different types of tobacco, cultivation practices, and harvesting practices are set forth. For various representative other plant types from the Nicotiana species see: Goodspeed, The Genus Nicotiana, (Chonica Botanica) (1954); U.S. Patent No. 4,660,577 to Sensabaugh, Jr. et al; U.S. Patent No. 5,387,416 to White et al, and Lawson US Patent No. 7,025,066 to et al; US Patent Application Publication No. 2006/0037623 to Lawrence, Jr., and US Patent Application Publication No. 2008/0245377 to Marshall et al; each of which is incorporated herein by reference. Exemplary tobacco species include: N. tabacum, N. rustica, N. alata, N. arentsii, N. excelsior, N. forgetiana ), N. glauca, N. glutinosa, N. gossei, N. kawakamii, N. knightiana , N.langsdorffi, N.otophora, N.setchelli, N.sylvestris, N.tomentosa, N.tomentosa .tomentosiformis), N. undulata, N.xsanderae, N. africana, N. amplexicaulis, N. benavidesii , N. bonariensis, N. debneyi, N. longiflora, N. maritina, N. megalosiphon, Western tobacco ( N.occidentalis), N. paniculata, N. plumbaginifolia, N. raimondii, N. rosulata, N. simulans), N. stocktonii, N. suaveolens, N. umbratica, N. velutina, N. wigandioides, none N.acaulis, N.acuminata, N.attenuata, N.benthamiana, N.cavicola, Cree N. clevelandii, N. cordifolia, N. corymbosa, N. fragrans, N. goodspeedii, N. angustifolia Tobacco (N.linearis), Moses' tobacco (N.miersii), bare-stem tobacco (N.nudicaulis), obtusifolia (N.obtusifolia), thrips tobacco Herspe ris subspecies (N.occdentalis subsp.Hersperis), N. pauciflora, N. petunioides, N. quadrivalvis, N. repanda), N. rotundifolia, N. solanifolia, and N. spegazzinii.

使用遗传修饰或杂交育种技术，可以衍生出烟草属种（例如，可以对烟草植物进行遗传工程改造或杂交育种，以增加或减少组分、性状或特征的产生）。参见，例如，在下述文献中阐述的植物的遗传修饰的类型： Fitzmaurice等人的美国专利号5,539,093；Wahab等人的美国专利号 5,668,295；Fitzmaurice等人的美国专利号5,705,624；Weigl的美国专利号5,844,119；Dominguez等人的美国专利号6,730,832；Liu等人的美国专利号7,173,170；Colliver等人的美国专利号7,208,659，和Benning 等人的美国专利号7,230,160；Conkling等人的美国专利申请公开号 2006/0236434；和Nielsen等人的PCT WO2008/103935。Nicotiana species can be derived using genetic modification or cross-breeding techniques (for example, tobacco plants can be genetically engineered or cross-breeded to increase or decrease the production of components, traits or characteristics). See, for example, the types of genetic modification of plants described in: Fitzmaurice et al., U.S. Patent No. 5,539,093; Wahab et al., U.S. Patent No. 5,668,295; Fitzmaurice et al., U.S. Patent No. 5,705,624; Weigl, U.S. Patent No. 5,844,119 U.S. Patent No. 6,730,832 to Dominguez et al.; U.S. Patent No. 7,173,170 to Liu et al.; U.S. Patent No. 7,208,659 to Colliver et al., and U.S. Patent No. 7,230,160 to Benning et al.; U.S. Patent Application Publication No. 2006/0236434 to Conkling et al. and PCT WO2008/103935 by Nielsen et al.

就无烟的和可抽吸的烟草产品的制备而言，通常对收获的烟草属种植物进行干制工艺。针对不同类型的烟草的不同类型的干制工艺的描述，参见：Tobacco Production,Chemistry and Technology,Davis等人（编）（1999）。用于干制烟道烘烤的烟草的示例性技术和条件参见：Nestor等人,Beitrage Tabakforsch.Int.,20,467-475（2003）和Peele的美国专利号6,895,974，它们通过引用并入本文。晾干烟草的代表性技术和条件参见：Groves等人的美国专利号7,650,892；Roton等人,Beitrage Tabakforsch.Int.,21,305-320（2005）和Staaf等人,Beitrage Tabakforsch.Int.,21,321-330（2005），它们通过引用并入本文。可以对某些类型的烟草进行替代类型的干制工艺，诸如火烤或晒干。优选地，然后老化干制收获的烟草。这样，用于制备烟草组合物或产品的烟草最优选地包含已经干制和老化的烟草组分。可以在使用之前对在本发明中使用的烟草材料进行额外的加工，诸如发酵、漂白等。For the manufacture of smokeless and smokeable tobacco products, harvested Nicotiana plants are typically subjected to a curing process. For a description of the different types of curing processes for different types of tobacco, see: Tobacco Production, Chemistry and Technology, Davis et al. (eds.) (1999). Exemplary techniques and conditions for drying flue-cured tobacco are found in: Nestor et al., Beitrage Tabakforsch. Int., 20, 467-475 (2003) and US Patent No. 6,895,974 to Peele, which are incorporated herein by reference. Representative techniques and conditions for air-drying tobacco are found in: Groves et al., U.S. Patent No. 7,650,892; Roton et al., Beitrage Tabakforsch. Int., 21, 305-320 (2005) and Staaf et al., Beitrage Tabakforsch. Int., 21, 321-330 (2005), which are incorporated herein by reference. Alternative types of curing processes, such as fire curing or sun curing, can be performed on certain types of tobacco. Preferably, the harvested tobacco is then aged and cured. As such, tobacco used to prepare tobacco compositions or products most preferably comprises tobacco components that have been cured and aged. Tobacco material used in the present invention may be subjected to additional processing, such as fermentation, bleaching, etc., prior to use.

烟草属种的植物的至少一部分（例如，烟草部件的至少一部分）可以以未成熟形式使用。也就是说，可以在达到通常认为成熟或到期的阶段之前，收获植物或植物的至少一部分。这样，例如，当烟草植物处于出芽点时、正在开始形成叶时、正在开始开花时等，可以收获烟草。At least a part of a plant of the Nicotiana genus (eg, at least a part of a tobacco part) can be used in an immature form. That is, the plant or at least a portion of the plant may be harvested prior to reaching a stage generally considered mature or mature. Thus, for example, tobacco can be harvested when the tobacco plant is at the budding point, is beginning to form leaves, is beginning to flower, and the like.

烟草属种的植物的至少一部分（例如，烟草部件的至少一部分）可以以成熟形式使用。也就是说，当植物或植物的至少一部分达到传统地认为成熟、过熟或到期的点，收获所述植物（或植物部分）。这样，例如，通过使用农夫常用的烟草收获技术，可以收获香料烟草植物，可以收获白肋烟草植物，或可以收获弗吉尼亚烟叶，或根据部位特征（stalkposition）来收获（prime）。At least a portion of a plant of the Nicotiana genus (eg, at least a portion of a tobacco part) can be used in a mature form. That is, a plant (or plant part) is harvested when the plant or at least a part of a plant has reached a point traditionally considered mature, overripe or mature. Thus, for example, oriental tobacco plants can be harvested, burley tobacco plants can be harvested, or Virginia tobacco leaves can be harvested, or primed, by using tobacco harvesting techniques commonly used by farmers.

收获以后，烟草属种植物或其部分可以以青形式使用（例如，烟草可以在没有经过任何烘烤过程的情况下使用）。例如，可以对青形式的烟草进行冷冻、辐照、黄化、干燥、烹调（例如，烤、炸或煮），或以其它方式进行储存或处理，用于以后使用。也可以使这样的烟草处于老化条件。After harvesting, Nicotiana plants or parts thereof may be used in green form (eg, tobacco may be used without any curing process). For example, tobacco in green form can be frozen, irradiated, yellowed, dried, cooked (eg, roasted, fried, or boiled), or otherwise stored or processed for later use. Such tobacco may also be subjected to aging conditions.

可以包装和干燥烟草材料，然后研磨成期望的形式。例如，在某些情况下，可以用含有诸如糖（例如，果糖、葡萄糖和蔗糖）、湿润剂（例如，甘油和丙二醇）、调味成分（例如，可可粉和甘草）等组分的水性外壳包装所述烟草材料制剂。可以将非水性的包装组分以约1%至约15%（基于烟草的干重）的量施加于烟草。The tobacco material can be wrapped and dried, then ground into the desired form. For example, in some cases, it may be packaged in an aqueous shell containing ingredients such as sugars (e.g., fructose, glucose, and sucrose), humectants (e.g., glycerin and propylene glycol), flavoring ingredients (e.g., cocoa powder, and licorice) The tobacco material formulation. The non-aqueous packaging component may be applied to the tobacco in an amount of about 1% to about 15% (based on the dry weight of the tobacco).

在所述烟草组合物或产品中采用的烟草材料的至少一部分可以具有提取物的形式。通过使用具有水性特性的溶剂（诸如蒸馏水或自来水）提取烟草，可获得烟草提取物。这样，通过用水提取烟草，可以提供水性烟草提取物，以使水不溶性浆材料与水性溶剂以及溶解和分散在其中的水溶性的和水分散性的烟草组分分离。可以以多种形式使用烟草提取物。例如，水性烟草提取物可以分离成基本上不含溶剂的形式，诸如可作为使用喷雾干燥或冷冻干燥或其它类似类型加工步骤的结果获得。可替换地，水性烟草提取物可采用液体形式，并且这样，通过选择用于提取的溶剂的量、通过去除溶剂而浓缩液体烟草提取物、通过添加溶剂以稀释液体烟草提取物、或类似方法，可以控制液体溶剂中的烟草可溶物的含量。用于提取烟草组分的示例性技术描述在下述文献中：Fiore的美国专利号4,144,895；Osborne，Jr.等人的美国专利号4,150,677；Reid的美国专利号4,267,847； Wildman等人的美国专利号4,289,147；Brummer等人的美国专利号 4,351,346；Brummer等人的美国专利号4,359,059；Muller的美国专利号 4,506,682；Keritsis的美国专利号4,589,428；Soga等人的美国专利号 4,605,016；Poulose等人的美国专利号4,716,911；Niven，Jr.等人的美国专利号4,727,889；Bernasek等人的美国专利号4,887,618；Clapp等人的美国专利号4,941,484；Fagg等人的美国专利号4,967,771；Roberts等人的美国专利号4,986,286；Fagg等人的美国专利号5,005,593；Grubbs 等人的美国专利号5,018,540；White等人的美国专利号5,060,669；Fagg 的美国专利号5,065,775；White等人的美国专利号5,074,319；White等人的美国专利号5,099,862；White等人的美国专利号5,121,757；Fagg的美国专利号5,131,414；Munoz等人的美国专利号5,131,415；Fagg的美国专利号5,148,819；Kramer的美国专利号5,197,494；Smith等人的美国专利号5,230,354；Fagg的美国专利号5,234,008；Smith的美国专利号 5,243,999；Raymond等人的美国专利号5,301,694；Gonzalez-Parra等人的美国专利号5,318,050；Teague的美国专利号5,343,879；Newton的美国专利号5,360,022；Clapp等人的美国专利号5,435,325；Brinkley等人的美国专利号5,445,169；Lauterbach的美国专利号6,131,584；Turpen 等人的美国专利号6,284,875；Kierulff等人的美国专利号6,298,859； Mua等人的美国专利号6,772,767；Berit等人的美国专利号6,817,970； Bratcher等人的美国专利号6,906,172；Turpen等人的美国专利号7,034,128；Bratcher等人的美国专利号7,048,211；和Thompson的美国专利号7,337,782，它们都通过引用并入本文。At least a portion of the tobacco material employed in the tobacco composition or product may be in the form of an extract. Tobacco extracts are obtained by extracting tobacco using a solvent having aqueous properties such as distilled or tap water. Thus, by extracting the tobacco with water, an aqueous tobacco extract can be provided to separate the water-insoluble pulp material from the aqueous solvent and the water-soluble and water-dispersible tobacco components dissolved and dispersed therein. Tobacco extracts can be used in a variety of forms. For example, an aqueous tobacco extract may be isolated into a substantially solvent-free form, such as may be obtained as a result of the use of spray-drying or freeze-drying or other similar types of processing steps. Alternatively, the aqueous tobacco extract may be in liquid form, and as such, by selecting the amount of solvent used for extraction, concentrating the liquid tobacco extract by removing the solvent, diluting the liquid tobacco extract by adding a solvent, or the like, The content of tobacco solubles in the liquid solvent can be controlled. Exemplary techniques for extracting tobacco components are described in: U.S. Patent No. 4,144,895 to Fiore; U.S. Patent No. 4,150,677 to Osborne, Jr. et al.; U.S. Patent No. 4,267,847 to Reid; U.S. Patent No. 4,289,147 to Wildman et al. U.S. Patent No. 4,351,346 to Brummer et al.; U.S. Patent No. 4,359,059 to Brummer et al.; U.S. Patent No. 4,506,682 to Muller; U.S. Patent No. 4,589,428 to Keritsis; U.S. Patent No. 4,727,889 to Niven, Jr. et al.; U.S. Patent No. 4,887,618 to Bernasek et al.; U.S. Patent No. 4,941,484 to Clapp et al.; U.S. Patent No. 4,967,771 to Fagg et al.; U.S. Patent No. 5,005,593 to Grubbs et al.; U.S. Patent No. 5,018,540 to Grubbs et al.; U.S. Patent No. 5,060,669 to White et al.; U.S. Patent No. 5,065,775 to Fagg; U.S. Patent No. 5,121,757 to White et al.; U.S. Patent No. 5,131,414 to Fagg; U.S. Patent No. 5,131,415 to Munoz et al.; U.S. Patent No. 5,148,819 to Fagg; US Patent No. 5,234,008 to Smith; US Patent No. 5,243,999 to Smith; US Patent No. 5,301,694 to Raymond et al.; US Patent No. 5,318,050 to Gonzalez-Parra et al.; US Patent No. 5,343,879 to Teague; U.S. Patent No. 5,435,325 to Brinkley et al.; U.S. Patent No. 5,445,169 to Brinkley et al.; U.S. Patent No. 6,131,584 to Lauterbach; U.S. Patent No. 6,284,875 to Turpen et al.; U.S. Patent No. 6,817,970 to Bratcher et al.; U.S. Patent No. 6,906,172 to Bratcher et al.; Tur US Patent No. 7,034,128 to Pen et al.; US Patent No. 7,048,211 to Bratcher et al.; and US Patent No. 7,337,782 to Thompson, all of which are incorporated herein by reference.

通常以可以被描述为微粒（即，碎粒、研磨粒、粒化形式或粉末形式）的形式使用所述烟草材料。用于提供精细粉碎的或粉末类型的形式的烟草材料的方式可以变化。优选地，使用用于研磨、粉碎等的设备和技术，将植物块或片粉碎、研磨或粉末化成微粒形式。最优选地，植物材料在研磨或粉碎（使用诸如锤磨机、刀盘、空气调节研磨机等设备）过程中是相对干燥的形式。例如，当烟草块或片的含水量小于约15重量%或小于约5重量%时，可以对其进行研磨或碾磨。最优选地，以具有小于约50微米的平均粒度的块或片的形式使用烟草材料。在一个实施方案中，所述烟草颗粒的平均粒度可以小于或等于约25微米。在某些情况下，可以调节所述烟草颗粒的大小以穿过筛孔。如果需要的话，可以使用气流分级设备来确保，可以收集具有期望的尺寸或尺寸范围的小尺寸的烟草颗粒。如果需要的话，可以将不同大小的粒化烟草块混合到一起。The tobacco material is typically used in a form that may be described as particulate (ie, nibs, ground grains, granulated form, or powdered form). The means for providing the tobacco material in finely divided or powder type form may vary. Preferably, the plant pieces or pieces are comminuted, ground or pulverized into particulate form using equipment and techniques for grinding, pulverizing or the like. Most preferably, the plant material is in relatively dry form during grinding or crushing (using equipment such as hammer mills, burrs, air conditioned grinders, etc.). For example, when the tobacco block or sheet has a moisture content of less than about 15% by weight or less than about 5% by weight, it can be ground or milled. Most preferably, the tobacco material is used in the form of blocks or sheets having an average particle size of less than about 50 microns. In one embodiment, the average particle size of the tobacco particles may be less than or equal to about 25 microns. In some cases, the tobacco particles may be sized to pass through the mesh. Airflow classification equipment may be used, if desired, to ensure that small sized tobacco particles of a desired size or size range are collected. Pelletized tobacco pieces of different sizes can be blended together if desired.

在所述无烟烟草组合物内的烟草材料的相对量可以变化，但是烟草材料通常是优势成分。优选地，基于组合物的干重，在所述无烟烟草组合物内的烟草材料制剂的量是至少约25%或至少约30%。在某些情况下，在所述无烟烟草组合物内的其它组分的量可以超过约40%（基于干重）。在所述无烟烟草组合物内的烟草材料制剂的典型范围是约25干重%至约60干重%，更典型地约30干重%至约40干重%。The relative amount of tobacco material within the smokeless tobacco composition can vary, but generally tobacco material is the predominant ingredient. Preferably, the amount of tobacco material formulation within the smokeless tobacco composition is at least about 25% or at least about 30%, based on the dry weight of the composition. In certain instances, the amount of other components within the smokeless tobacco composition can exceed about 40% (dry weight basis). A typical range of tobacco material formulation within the smokeless tobacco composition is from about 25% to about 60% by dry weight, more typically from about 30% to about 40% by dry weight.

在某些实施方案中，所述烟草材料可以不是优势成分，其中所述烟草材料可以呈具有液体形式、喷雾干燥形式或脱水形式的烟草提取物形式。在所述无烟烟草组合物内的这类烟草材料的典型范围是约5干重%至约40 干重%、约5干重%至约25干重%、约10干重%至约30干重%、或约20干重% 至约40干重%.In certain embodiments, the tobacco material may not be the predominant ingredient, wherein the tobacco material may be in the form of a tobacco extract in a liquid form, a spray-dried form, or a dehydrated form. Typical ranges for such tobacco materials in the smokeless tobacco composition are from about 5% by dry weight to about 40% by dry weight, from about 5% by dry weight to about 25% by dry weight, from about 10% by dry weight to about 30% by dry weight. % by dry weight, or about 20% by dry weight to about 40% by dry weight.

在与任何液体物质混合以形成无烟烟草组合物之前，烟草材料制剂的含水量可以变化。最优选地，烟草材料制剂的含水量是小于约10重量%，且可以是小于约5%，经常是小于约2.5重量%。用于控制烟草材料制剂的含水量的方式可以变化。例如，可以对烟草材料制剂进行热法加热或对流加热。作为一个具体实施例，可以在约40℃至约95℃的温度，在暖风中将烟草材料制剂烘干，保持适当地达到期望的含水量的时间长度。例如，可以将烟草材料制剂在约54℃至约60℃干燥约12小时至约24小时。The moisture content of the tobacco material formulation may be varied prior to mixing with any liquid substances to form the smokeless tobacco composition. Most preferably, the moisture content of the tobacco material formulation is less than about 10% by weight, and may be less than about 5%, often less than about 2.5% by weight. The means for controlling the moisture content of tobacco material formulations can vary. For example, the tobacco material formulation can be heated thermally or convectively. As a specific example, the tobacco material formulation can be dried in warm air at a temperature of about 40°C to about 95°C for a length of time suitable to achieve the desired moisture content. For example, the tobacco material formulation can be dried at about 54°C to about 60°C for about 12 hours to about 24 hours.

在某些情况下，在制备烟草材料制剂之前，可以对烟草块或片进行辐照，或者对这些块或片进行巴氏消毒，或者用其它方式进行受控的热处理。另外，如果需要的话，在制备全部或部分烟草材料制剂之后，可以对组分材料进行辐照，或者对那些组分材料进行巴氏消毒，或者用其它方式进行受控的热处理。例如，可以制备烟草材料制剂，然后辐照或巴氏消毒，然后向该制剂施加调味成分。代表性的方法参见：Mua等人的美国专利公开号2009/0025738；Brinkley等人的美国专利公开号2009/0025739；和 Beeson等人的美国专利公开号2011/0247640，它们通过引用并入本文。In some cases, tobacco blocks or sheets may be irradiated, or pasteurized, or otherwise subjected to a controlled heat treatment prior to preparation of the tobacco material formulation. Additionally, after preparation of all or a portion of the tobacco material formulation, the component materials may be irradiated, or those component materials may be pasteurized, or otherwise subjected to a controlled heat treatment, if desired. For example, a formulation of tobacco material can be prepared, then irradiated or pasteurized, and flavoring ingredients applied to the formulation. For representative methods see: Mua et al., US Patent Publication No. 2009/0025738; Brinkley et al., US Patent Publication No. 2009/0025739; and Beeson et al., US Patent Publication No. 2011/0247640, which are incorporated herein by reference.

还可以与其它材料或成分（即，添加剂）一起，加工、掺合、配制、组合和混合用于生产无烟烟草产品的烟草材料制剂。参见，例如，在下述文献中阐述的那些代表性组分、组分的组合、那些组分和成分相对于烟草的相对量、以及使用那些组分的方式和方法：Holton,等人的美国专利公开号2007/0062549，和Holton,等人的美国专利公开号2007/0186941，它们中的每一篇通过引用并入本文。Tobacco material formulations may also be processed, blended, formulated, combined and mixed with other materials or ingredients (ie, additives) for the production of smokeless tobacco products. See, for example, those representative components, combinations of components, relative amounts of those components and components relative to tobacco, and ways and methods of using those components set forth in: Holton, et al. Publication No. 2007/0062549, and US Patent Publication No. 2007/0186941 to Holton, et al., each of which is incorporated herein by reference.

所述添加剂可以是人工添加剂，或可以从草药或生物源得到或衍生出。示例性的添加剂类型包括：盐（例如，氯化钠、氯化钾、柠檬酸钠、柠檬酸钾、乙酸钠、乙酸钾等）、天然甜味剂（例如，果糖、蔗糖、葡萄糖、麦芽糖、香草醛、乙基香草醛葡萄糖苷、甘露糖、半乳糖、乳糖等）、人工甜味剂（例如，三氯蔗糖、糖精、阿斯巴甜、安赛蜜、纽甜等）、有机和无机填充剂（例如，细粒、已加工细粒、疏松细粒、麦芽糊精、右旋糖、碳酸钙、磷酸钙、玉米淀粉、乳糖、糖醇（诸如异麦芽酮糖醇、甘露醇、木糖醇或山梨醇）、精细粉碎的纤维素、植物蛋白等）、粘合剂（例如，聚维酮、羧甲基纤维素钠和其它改性纤维素类粘合剂、藻酸钠、黄原胶、淀粉基粘合剂、阿拉伯树胶、结冷胶、卵磷脂等）、胶凝剂（例如，鱼明胶）、pH 调节剂或缓冲剂（例如，金属氢氧化物，优选碱金属氢氧化物，如氢氧化钠和氢氧化钾，和其它碱金属缓冲剂如金属碳酸盐，优选碳酸钾或碳酸钠，或金属碳酸氢盐如碳酸氢钠等）、乳化剂、着色剂（例如，染料和颜料、包括焦糖色和二氧化钛等）、湿润剂（例如，甘油、丙二醇等）、口腔护理添加剂（例如，百里香油、桉叶油和锌）、防腐剂（例如，山梨酸钾等）、糖浆（例如，蜂蜜、高果糖玉米糖浆等）、崩解或压缩助剂（例如，微晶纤维素、交联羧甲基纤维素钠、交聚维酮、淀粉羟乙酸钠、预胶凝化玉米淀粉等）、调味剂和调味混合物、抗氧化剂、及它们的混合物。示例类型的添加剂可以包括在例如Gao等人的美国专利公开号2010/0291245中描述的那些，该专利在前面通过引用并入本文。The additives may be artificial, or may be obtained or derived from herbal or biological sources. Exemplary types of additives include: salts (e.g., sodium chloride, potassium chloride, sodium citrate, potassium citrate, sodium acetate, potassium acetate, etc.), natural sweeteners (e.g., fructose, sucrose, glucose, maltose, Vanillin, ethyl vanillin glucoside, mannose, galactose, lactose, etc.), artificial sweeteners (e.g., sucralose, saccharin, aspartame, acesulfame potassium, neotame, etc.), organic and inorganic Fillers (e.g., granules, processed granules, loose granules, maltodextrin, dextrose, calcium carbonate, calcium phosphate, corn starch, lactose, sugar alcohols (such as isomalt, mannitol, wood sugar alcohol or sorbitol), finely divided cellulose, vegetable protein, etc.), binders (for example, povidone, sodium carboxymethylcellulose and other modified cellulose-based binders, sodium alginate, yellow Original gum, starch-based binders, gum arabic, gellan gum, lecithin, etc.), gelling agents (e.g., fish gelatin), pH adjusters or buffers (e.g., metal hydroxides, preferably alkali metal hydroxides substances, such as sodium hydroxide and potassium hydroxide, and other alkali metal buffers such as metal carbonates, preferably potassium carbonate or sodium carbonate, or metal bicarbonates such as sodium bicarbonate, etc.), emulsifiers, colorants (for example, dyes and pigments, including caramel color and titanium dioxide, etc.), humectants (e.g., glycerin, propylene glycol, etc.), oral care additives (e.g., thyme oil, eucalyptus oil, and zinc), preservatives (e.g., potassium sorbate, etc.), Syrups (e.g., honey, high fructose corn syrup, etc.), disintegration or compression aids (e.g., microcrystalline cellulose, croscarmellose sodium, crospovidone, sodium starch glycolate, pregelatinized cornstarch, etc.), flavorings and flavoring mixtures, antioxidants, and mixtures thereof. Exemplary types of additives may include those described, for example, in US Patent Publication No. 2010/0291245 to Gao et al., previously incorporated herein by reference.

这样的添加剂可以以粉末或颗粒形式提供用于与烟草材料制剂一起混合，或者可以以其它方式以液体形式提供。最优选地，以具有小于约50微米的平均粒度的块或片的形式，使用以粉末或颗粒形式提供的添加剂。根据一些方面，所述添加剂的平均粒度可以是约25微米或更小。以粉末或颗粒形式提供的添加剂的含水量可以变化。最优选地，以粉末或颗粒形式提供的添加剂的含水量是小于约10重量%，且可以是小于约5%，经常是小于约2.5重量%。在加入任何液体添加剂之前，可以在例如具有平桨的Hobart 混合器中，将所述添加剂与微粒状烟草材料一起混合。在提供液体添加剂的情况下，得到的混合物仍然可以具有小于约10重量%的相对较低的含水量，且可以是小于约5%，经常是小于约2.5重量%。在无烟烟草产品内的各种添加剂组分的相对量可以变化。Such additives may be provided in powder or granular form for mixing with the tobacco material formulation, or may otherwise be provided in liquid form. Most preferably, additives provided in powder or granular form are used in the form of blocks or flakes having an average particle size of less than about 50 microns. According to some aspects, the average particle size of the additive may be about 25 microns or less. The moisture content of additives provided in powder or granular form may vary. Most preferably, the moisture content of additives provided in powder or granular form is less than about 10% by weight, and may be less than about 5%, often less than about 2.5% by weight. The additive may be mixed with the particulate tobacco material, eg, in a Hobart mixer with flat blades, prior to the addition of any liquid additive. Where liquid additives are provided, the resulting mixture may still have a relatively low water content of less than about 10% by weight, and may be less than about 5%, often less than about 2.5% by weight. The relative amounts of the various additive components within the smokeless tobacco product can vary.

前述类型的添加剂可以一起使用(例如，作为添加剂制剂)，或单独使用(例如，在最终烟草产品的制备所涉及的不同阶段，可以加入各种添加剂组分)。在无烟烟草制剂内的各种组分的相对量可以变化，且通常进行选择，从而给烟草产品提供期望的感觉和性能特征。此外，可以将前述类型的添加剂包囊提供在终产品或组合物中。示例性的包囊化添加剂参见：例如， Atchley的WO2010/132444A2，其已经在前面通过引用并入本文。Additives of the foregoing types may be used together (eg, as an additive formulation), or individually (eg, various additive components may be added at different stages involved in the manufacture of the final tobacco product). The relative amounts of the various components within a smokeless tobacco formulation can vary, and are typically selected so as to provide the desired sensory and performance characteristics to the tobacco product. Additionally, additives of the aforementioned type may be provided encapsulated in the final product or composition. For exemplary encapsulated additives see: eg, WO2010/132444A2 to Atchley, which has been previously incorporated herein by reference.

用于本发明的无烟烟草组合物的上述类型的添加剂中的任一种可以如下从烟草材料衍生出：对烟草植物的至少一部分（例如，叶子、种子、花、茎、根或叶柄）进行分离过程，所述分离过程通常可以包括多个相继的提取步骤，以便分离烟草材料的所需组分。示例性的分离过程包括色谱法、蒸馏、过滤、重结晶、溶剂-溶剂分配、冷榨、溶剂提取（例如，使用溶剂诸如水、醇或烃，诸如庚烷或己烷）、或它们的组合。在用于本发明的组合物中之前，可以对得到的分离的烟草组分进行化学转化。示例性的化学转化包括：氢化、酯化、酯交换、异构转化、缩醛形成、缩醛分解、酸/碱反应、水解、热处理、酶处理和这些步骤的组合。用于制备在本发明的组合物中使用的烟草分离物的技术参见，例如，Coleman,III等人的美国专利公开号2011/0174323和Coleman,III等人的美国专利公开号 2011/0259353，它们通过引用整体并入本文。可以存在于烟草分离物中的化合物的类型的例子包括：烃、纤维素、醇、醛、酮、羧酸、氨基酸、酯、内酯、酸酐、碳水化合物（例如，还原糖）、苯酚、醌、醚、腈、胺、酰胺、酰亚胺、色素体颜料、蛋白质、辅酶-Q、果胶、淀粉、木质素和脂质。其它例子作为天然焦油稀释剂描述在Lipowicz的PCT WO2007/012980中，它通过引用整体并入本文。从烟草分离物制备的无烟烟草添加剂的类型和功能将随分离物的组成而变化，所述分离物的组成可以部分地基于采用的提取过程、涉及的烟草植物的部分、使用的化学转化的类型等而变化。某些烟草分离物可以为本发明的无烟烟草组合物提供糖、填充剂、粘合剂、崩解或压缩助剂或调味剂。Any of the aforementioned types of additives for use in the smokeless tobacco compositions of the present invention may be derived from tobacco material by subjecting at least a portion of a tobacco plant (e.g., leaves, seeds, flowers, stems, roots, or petioles) to A separation process, which may generally include a number of sequential extraction steps in order to separate the desired components of the tobacco material. Exemplary isolation procedures include chromatography, distillation, filtration, recrystallization, solvent-solvent partitioning, cold pressing, solvent extraction (e.g., using solvents such as water, alcohols, or hydrocarbons such as heptane or hexane), or combinations thereof . The resulting isolated tobacco component may be chemically transformed prior to use in the compositions of the present invention. Exemplary chemical transformations include: hydrogenation, esterification, transesterification, isomeric conversion, acetal formation, acetal decomposition, acid/base reaction, hydrolysis, thermal treatment, enzymatic treatment and combinations of these steps. Techniques for preparing tobacco isolates for use in the compositions of the present invention are found, for example, in U.S. Patent Publication No. 2011/0174323 to Coleman, III et al. and U.S. Patent Publication No. 2011/0259353 to Coleman, III et al., which Incorporated herein in its entirety by reference. Examples of types of compounds that may be present in tobacco isolates include: hydrocarbons, cellulose, alcohols, aldehydes, ketones, carboxylic acids, amino acids, esters, lactones, anhydrides, carbohydrates (e.g., reducing sugars), phenols, quinones , ethers, nitriles, amines, amides, imides, chromoplast pigments, proteins, coenzyme-Q, pectin, starch, lignin and lipids. Other examples are described as natural tar diluents in PCT WO2007/012980 to Lipowicz, which is hereby incorporated by reference in its entirety. The type and function of smokeless tobacco additives prepared from tobacco isolates will vary with the composition of the isolate, which may be based in part on the extraction process employed, the parts of the tobacco plant involved, the chemical transformations used, Type etc. vary. Certain tobacco isolates can provide sugars, fillers, binders, disintegration or compression aids, or flavoring agents to the smokeless tobacco compositions of the present invention.

本文使用的“调味剂”或“矫味剂”是，能够改变与无烟烟草组合物有关的感觉特性的任意可口的或芳香的物质。调味剂可以改变的示例性感觉特性包括，味道、口感、湿度、冷/热、和/或芳香/香气。所述调味剂可以是天然的或合成的，并且这些调味剂的特性可描述为，但不限于：清新型、香甜型、草药味、糖果味、花香型、水果味或香料型。调味剂的具体类型包括、但不限于：香草、咖啡、巧克力、奶油、薄荷、留兰香、薄荷醇、薄荷、冬青、薰衣草、小豆蔻、肉豆蔻、肉桂、丁香、卡藜、檀香、蜂蜜、茉莉、姜、八角、鼠尾草、甘草、柠檬、橙、苹果、桃、石灰、樱桃和草莓。在本发明中使用的调味剂还可以包括被视作湿润剂、冷却剂或平滑剂的组分，如桉叶油（eucalyptus）。这些调味剂可以纯粹地（即，单独地）或复合地（例如，留兰香和薄荷醇，或橙和肉桂）提供。在某些情况下，所述调味剂可以以喷雾干燥形式提供。调味剂通常以约0.5干重% 至约10干重%、经常是约1干重%至约6干重%、最经常是约2干重%至约5 干重%的量存在。As used herein, a "flavoring agent" or "flavoring agent" is any palatable or aromatic substance capable of altering the sensory characteristics associated with a smokeless tobacco composition. Exemplary sensory attributes that can be altered by flavoring agents include taste, mouthfeel, humidity, cold/heat, and/or aroma/aroma. The flavorings may be natural or synthetic, and the flavorings may be characterized as, but not limited to: fresh, sweet, herbal, candy, floral, fruity or spice. Specific types of flavoring agents include, but are not limited to: vanilla, coffee, chocolate, cream, peppermint, spearmint, menthol, peppermint, wintergreen, lavender, cardamom, nutmeg, cinnamon, cloves, quinoa, sandalwood, Honey, Jasmine, Ginger, Star Anise, Sage, Licorice, Lemon, Orange, Apple, Peach, Lime, Cherry and Strawberry. Flavoring agents used in the present invention may also include components considered humectants, cooling agents or smoothing agents, such as eucalyptus. These flavorings may be provided purely (ie, alone) or in combination (eg, spearmint and menthol, or orange and cinnamon). In some cases, the flavoring agent may be provided in a spray-dried form. Flavoring agents are typically present in amounts of from about 0.5% to about 10% by dry weight, often from about 1% to about 6% by dry weight, most often from about 2% to about 5% by dry weight.

可以使用天然或人工形式的甜味剂，或使用人工甜味剂和天然甜味剂的组合。在一个实施方案中，三氯蔗糖是主要的甜味剂成分。当存在甜味剂（人工甜味剂和/或天然糖）时，所述甜味剂的代表量可以占组合物总干重的至少约0.2%或至少约5%。优选地，基于组合物的总干重，在组合物中的甜味剂的量不超过约40%，经常不超过约35%，经常不超过约30%。Sweeteners may be used in natural or artificial forms, or a combination of artificial and natural sweeteners. In one embodiment, sucralose is the primary sweetener ingredient. When present, sweeteners (artificial sweeteners and/or natural sugars) can be present in representative amounts of at least about 0.2% or at least about 5% of the total dry weight of the composition. Preferably, the amount of sweetener in the composition is no more than about 40%, often no more than about 35%, often no more than about 30%, based on the total dry weight of the composition.

优选地，以足以给所述无烟烟草组合物提供所需的香味特性的量，使用糖浆。当存在糖浆（例如，高果糖玉米糖浆）时，所述糖浆的代表量可以占组合物总干重的小于约5%。Preferably, the syrup is used in an amount sufficient to provide the desired flavor profile to the smokeless tobacco composition. When present, syrup (eg, high fructose corn syrup) can represent less than about 5% of the total dry weight of the composition.

本公开内容的无烟烟草组合物通常可以包括至少一种除了多糖填充剂组分以外的填充剂成分。所述组合物的这类组分经常会实现多种功能，诸如增强某种器官感觉性质（诸如质感和口感），增强产品的粘着性或可压缩性等。当存在额外填充剂（有机和/或无机填充剂）时，所述额外填充剂的代表量可以占组合物总干重的至少约10%、至少约20%或至少约25%。优选地，基于组合物的总干重，在组合物中的额外填充剂的量不超过约50%，经常不超过约40%。在一个实施方案中，提供诸如山梨醇等糖醇作为额外填充剂。Smokeless tobacco compositions of the present disclosure may generally include at least one filler component other than the polysaccharide filler component. Such components of the composition often perform multiple functions, such as enhancing certain organoleptic properties such as texture and mouthfeel, enhancing the cohesiveness or compressibility of the product, and the like. When present, additional fillers (organic and/or inorganic) can be present in representative amounts of at least about 10%, at least about 20%, or at least about 25% of the total dry weight of the composition. Preferably, the amount of additional filler in the composition will not exceed about 50%, often not more than about 40%, based on the total dry weight of the composition. In one embodiment, sugar alcohols such as sorbitol are provided as additional bulking agents.

可以以足以给无烟烟草组合物提供所需感觉特性的量，使用盐(例如，氯化钠)。当存在盐时，所述盐的代表量通常占组合物的总干重的小于约 2%。Salt (eg, sodium chloride) can be used in an amount sufficient to provide the desired sensory characteristics to the smokeless tobacco composition. Salt, when present, typically represents less than about 2% of the total dry weight of the composition.

可以以足以给无烟烟草组合物提供所需水分特性的量，使用湿润剂（例如，甘油）。当存在湿润剂时，所述湿润剂的代表量通常占组合物的总干重的至少约1%，经常占至少约2重量%。在某些实施方案中，湿润剂的量是至少约10干重%、或至少约20干重%。一个示例性的干重范围是约1干重% 至约40重量%，更经常约3干重%至约35干重%。A humectant (eg, glycerin) can be used in an amount sufficient to provide the desired moisture characteristics to the smokeless tobacco composition. When present, a humectant is typically present in a representative amount of at least about 1%, often at least about 2% by weight of the total dry weight of the composition. In certain embodiments, the amount of humectant is at least about 10% by dry weight, or at least about 20% by dry weight. An exemplary dry weight range is about 1% dry weight to about 40% dry weight, more often about 3% dry weight to about 35% dry weight.

可以以足以给无烟烟草组合物提供所需物理特性和物理完整性的量，使用粘合剂。当存在粘合剂时，基于组合物的总干重，粘合剂的代表量可以占至少约5%、或至少约10%。优选地，在所述组合物内的粘合剂的量不超过组合物的总干重的约35%。基于组合物的总干重，在希望的组合物内的粘合剂的量经常不超过约20%，且经常不超过约15%。代表性的粘合剂包括各种天然胶质（其通常具有一定程度的水溶性），例如黄原胶、瓜尔胶、阿拉伯树胶、印度胶、黄蓍树胶、刺梧桐树胶、槐豆胶、结冷胶和它们的组合。The binder can be used in an amount sufficient to provide the desired physical properties and physical integrity to the smokeless tobacco composition. When present, a representative amount of binder can comprise at least about 5%, or at least about 10%, based on the total dry weight of the composition. Preferably, the amount of binder in the composition does not exceed about 35% of the total dry weight of the composition. The amount of binder in the desired composition often does not exceed about 20%, and often does not exceed about 15%, based on the total dry weight of the composition. Representative binders include various natural gums (which usually have some degree of water solubility) such as xanthan gum, guar gum, acacia gum, ghatti gum, tragacanth gum, karaya gum, locust bean gum, Gellan gum and combinations thereof.

可以以足以给无烟烟草组合物提供所需稳定特性的量，使用乳化剂。当存在乳化剂时，所述乳化剂的代表量通常占组合物的总干重的小于约5%。Emulsifiers can be used in amounts sufficient to provide the desired stabilizing characteristics to the smokeless tobacco composition. When present, emulsifiers are typically present in representative amounts of less than about 5% of the total dry weight of the composition.

基于无烟烟草组合物的总干重，代表性的无烟烟草组合物可以包含：约25%至约35%的烟草、约10%至约20%的多糖填充剂组分（例如，聚葡萄糖）、约0%至约1%的人工甜味剂、约25%至约35%的湿润剂、约1%至约2%的乳化剂、约3%至约5%的糖浆、约10%至约20%的粘合剂、至多约1%的量的调味成分、和至多约2%的量的盐。各成分的具体百分数和选择将随所需味道、质感和其它特性而变化。Based on the total dry weight of the smokeless tobacco composition, a representative smokeless tobacco composition may comprise: about 25% to about 35% tobacco, about 10% to about 20% polysaccharide filler component (e.g., polydextrose ), about 0% to about 1% artificial sweetener, about 25% to about 35% wetting agent, about 1% to about 2% emulsifier, about 3% to about 5% syrup, about 10% Binders up to about 20%, flavoring ingredients in amounts up to about 1%, and salt in amounts up to about 2%. The specific percentages and selection of ingredients will vary with the taste, texture and other characteristics desired.

用于组合无烟烟草组合物的各种组分的方式可以变化。可以在圆锥型掺合器、混合转鼓、带式掺合器等（诸如Hobart混合器）中将无烟烟草组合物的各种组分一起接触、组合或混合。这样，可以使各种组分与粉状烟草组分的总体混合物在性质上是相对均匀的。也参见例如在以下文献中阐述的方法类型：Solomon等人的美国专利号4,148,325；Korte等人的美国专利号6,510,855；和Williams的美国专利号6,834,654，它们中的每一篇通过引用并入本文。The manner in which the various components of the smokeless tobacco composition are combined can vary. The various components of the smokeless tobacco composition can be contacted, combined, or mixed together in a conical blender, mixing drum, ribbon blender, and the like, such as a Hobart blender. In this way, the overall mixture of the various components and the powdered tobacco component can be made to be relatively homogeneous in nature. See also, for example, the types of methods set forth in: US Patent No. 4,148,325 to Solomon et al; US Patent No. 6,510,855 to Korte et al; and US Patent No. 6,834,654 to Williams, each of which is incorporated herein by reference.

制备用于形成可溶解的无烟烟草组合物的各种成分，使得它们的混合物可以用于注射模塑方法中，用于形成无烟烟草产品。在一个方面，混合所有干燥成分，包括微粒状烟草材料和粘合剂。在这点上，可以至少将微粒状烟草材料、多糖填充剂组分和粘合剂放入混合容器（例如，Hobart混合器–Model N-50）中用于混合。在混合所述干燥成分以后，可以将液体混合物加入所述干燥的混合物中。也就是说，在某些情况下，可以加热某些成分（例如，糖浆、湿润剂、乳化剂），以形成液体融化物溶液。然后使得到的干燥成分和液体成分的混合物穿过研磨装置（例如，在Hobart混合器–Model M802上的磨肉机），从而经由挤出方法迫使液体成分进入干燥成分中，这会形成糊状物质。然后可以将挤出的物质放入小Hobart混合器中并混合，从而形成粉末颗粒。The various ingredients for forming the dissolvable smokeless tobacco composition are prepared such that their mixture can be used in an injection molding process for forming a smokeless tobacco product. In one aspect, all dry ingredients, including particulate tobacco material and binder, are mixed. In this regard, at least the particulate tobacco material, polysaccharide filler component, and binder may be placed into a mixing vessel (eg, Hobart mixer - Model N-50) for mixing. After mixing the dry ingredients, a liquid mixture can be added to the dry mixture. That is, in some cases, certain ingredients (eg, syrups, wetting agents, emulsifiers) may be heated to form a liquid melt solution. The resulting mixture of dry and liquid ingredients is then passed through a grinding device (e.g., a meat grinder on a Hobart mixer - Model M802), thereby forcing the liquid ingredients into the dry ingredients via extrusion, which forms a paste substance. The extruded mass can then be placed in a small Hobart mixer and mixed to form powder granules.

在制备无烟烟草组合物以后，可以使用注射模塑操作来形成无烟烟草锭剂产品。在这点上，可以使用注射模塑装置来对所述无烟烟草组合物施加挤压力。本文使用的术语“注射模塑”表示如下形成的产品：将液体、半液体或制粒组合物注射进或以其它方式驱入模具或其它成型装置中，并对注射的组合物施加挤压力。要注射模塑的无烟烟草组合物通常具有小于约5重量%的含水量，经常小于约2.5重量%。将所述无烟烟草组合物转移至模具，在有些情况下，所述模具可以是分成2个单独块的钢块。在某些情况下，可以使用所谓的“一体（one-up）”模具，其中模具块包括2半具有空心形状的钢。由所述模具形成的内部成形为提供与最终的锭剂产品有关的所需构型。在某些情况下，可以将模具块加热至高温，例如，至约 50℃到约100℃，优选至约60℃。将所述无烟烟草组合物倒入模具块中，然后将压缩压力施加于所述无烟烟草组合物，例如，使用水压机单元（例如，Wabach Hydraulic Press,Model12-102T,Serial2201）。根据一个方面，将至少约75,000kPa、优选至少约100,000kPa的挤压力施加于所述无烟烟草组合物，尽管施加的挤压力的量可以变化。例如，可以施加至少约30,000kPa至约120,000kPa的挤压力。After preparing the smokeless tobacco composition, an injection molding operation may be used to form a smokeless tobacco pastille product. In this regard, injection molding equipment may be used to apply extrusion force to the smokeless tobacco composition. As used herein, the term "injection molding" means a product formed by injecting or otherwise driving a liquid, semi-liquid, or pelletized composition into a mold or other molding device and applying extruding force to the injected composition . Smokeless tobacco compositions to be injection molded typically have a moisture content of less than about 5% by weight, often less than about 2.5% by weight. The smokeless tobacco composition is transferred to a mold, which in some cases may be a steel block divided into 2 separate pieces. In some cases, so-called "one-up" molds can be used, where the mold block consists of 2 halves of steel with a hollow shape. The inner shape formed by the mold is to provide the desired configuration with respect to the final tablet product. In some cases, the mold block may be heated to an elevated temperature, for example, to about 50°C to about 100°C, preferably to about 60°C. The smokeless tobacco composition is poured into mold blocks, and then compressive pressure is applied to the smokeless tobacco composition, eg, using a hydraulic press unit (eg, Wabach Hydraulic Press, Model 12-102T, Serial 2201 ). According to one aspect, a squeeze force of at least about 75,000 kPa, preferably at least about 100,000 kPa is applied to the smokeless tobacco composition, although the amount of squeeze force applied may vary. For example, a pressing force of at least about 30,000 kPa to about 120,000 kPa may be applied.

压缩所述无烟烟草组合物的时间量可以变化。例如，可以压缩所述无烟烟草组合物约1分钟至约5分钟。在施加挤压力以后，在将模具块冷却至约30℃到约40℃以后，可以从注射模具取出无烟烟草组合物。然后可以使所述无烟烟草组合物在环境温度或在约20℃至约25℃冷却。可以以重量为约4克至约15克的单块形式提供得到的锭剂产品，尽管本公开内容的方面不限于这样的重量。但是，应当指出，精确的注射模塑制剂可以取决于使用的设备、所需的终产品特征、施加的热/压力的量等。The amount of time for compressing the smokeless tobacco composition can vary. For example, the smokeless tobacco composition can be compressed for about 1 minute to about 5 minutes. After the extrusion force is applied, the smokeless tobacco composition can be removed from the injection mold after cooling the mold block to about 30°C to about 40°C. The smokeless tobacco composition can then be allowed to cool at ambient temperature or at about 20°C to about 25°C. The resulting lozenge product may be provided in individual pieces weighing from about 4 grams to about 15 grams, although aspects of the present disclosure are not limited to such weights. It should be noted, however, that the precise injection molding formulation may depend on the equipment used, the desired end product characteristics, the amount of heat/pressure applied, etc.

可溶解的无烟烟草锭剂产品可以以任意合适的预定形状或形式提供，且最优选地以具有丸、团粒、片、硬币、珠子、卵球形、柑橘（obloid）、立方体等一般形状的形式提供。无烟烟草产品的口感优选地是可轻轻咀嚼的和可溶解的特性。根据一个方面，所述可溶解的无烟烟草锭剂产品优选地能够在完全溶解之前在使用者的嘴中持续约10-15分钟。优选地，所述锭剂产品不会在其使用者嘴中在任何显著程度上剩下任何残余物，且不会给使用者的嘴造成光滑的、蜡样的或粘滑的感觉。The dissolvable smokeless tobacco lozenge product may be provided in any suitable predetermined shape or form, and most preferably in a form having the general shape of a pellet, pellet, tablet, coin, bead, ovoid, obloid, cube, etc. supply. The mouthfeel of the smokeless tobacco product is preferably chewable and dissolvable in character. According to one aspect, the dissolvable smokeless tobacco pastille product is preferably capable of remaining in the user's mouth for about 10-15 minutes before completely dissolving. Preferably, the lozenge product does not leave any residue to any appreciable extent in the mouth of its user and does not impart a slippery, waxy or slimy feel to the user's mouth.

根据某些方面，可以用其它适当的植物微粒组分（例如，茶微粒、咖啡微粒、草药微粒、香料微粒和/或它们的组合）替代锭剂组合物的烟草微粒组分。所述微粒通常可以以粉末形式提供，其可以提取自适当的植物源。According to certain aspects, the tobacco particulate component of the lozenge composition may be replaced with other suitable plant particulate components (eg, tea particulates, coffee particulates, herbal particulates, spice particulates, and/or combinations thereof). The microparticles are usually provided in powder form, which may be extracted from a suitable vegetable source.

可以在任意合适的包装中包装和储存本发明的产品。参见，例如，在下述文献中阐述的无烟型产品的各类容器：Henson等人的美国专利号 7,014,039；Kutsch等人的美国专利号7,537,110；Kutsch等人的美国专利号7,584,843；Thiellier的美国专利号D592,956，和Patel等人的美国专利号D594,154；Robinson等人的美国专利公开号2008/0173317；Clark 等人的美国专利公开号2009/0014343；Bjorkholm的美国专利公开号 2009/0014450；Bellamah等人的美国专利公开号2009/0250360；Gelardi 等人的美国专利公开号2009/0266837；Gelardi的美国专利公开号 2009/0223989；Thiellier的美国专利公开号2009/0230003；Gelardi的美国专利公开号2010/0084424；和Bailey等人的美国专利公开号2010/0133140；和2009年8月20日提交的Bailey等人的美国专利申请系列号29/342,212；2009年4月16日提交的Bailey等人的美国专利申请系列号12/425,180；2010年1月12日提交的Bailey等人的美国专利申请系列号12/685,819；和2010年6月11日提交的Gelardi等人的美国专利申请系列号12/814,015，它们通过引用并入本文。The products of the invention may be packaged and stored in any suitable packaging. See, for example, various containers of smokeless products set forth in: U.S. Patent No. 7,014,039 to Henson et al.; U.S. Patent No. 7,537,110 to Kutsch et al.; U.S. Patent No. 7,584,843 to Kutsch et al.; U.S. Patent No. 7,584,843 to Thiellier No. D592,956, and U.S. Patent No. D594,154 to Patel et al; U.S. Patent Publication No. 2008/0173317 to Robinson et al; U.S. Patent Publication No. 2009/0014343 to Clark et al; U.S. Patent Publication No. 2009/0014450 to Bjorkholm U.S. Patent Publication No. 2009/0250360 by Bellamah et al.; U.S. Patent Publication No. 2009/0266837 by Gelardi et al.; U.S. Patent Publication No. 2009/0223989 by Gelardi; U.S. Patent Publication No. 2009/0230003 by Thiellier; 2010/0084424; and U.S. Patent Publication No. 2010/0133140 to Bailey et al.; and U.S. Patent Application Serial No. 29/342,212 to Bailey et al., filed August 20, 2009; and Bailey et al., filed April 16, 2009 U.S. Patent Application Serial No. 12/425,180 to Bailey et al., filed January 12, 2010; and U.S. Patent Application Serial No. 12/685,819 to Bailey et al., filed June 11, 2010 12/814,015, which are incorporated herein by reference.

实验部分Experimental part

提供下述实施例来解释与本发明有关的其它方面，但是所述实施例不应解释为限制其范围。除非另外指出，所有份数和百分数按干重计。The following examples are provided to illustrate other aspects related to the present invention, but the examples should not be construed as limiting the scope thereof. All parts and percentages are by dry weight unless otherwise indicated.

实施例1Example 1

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

制备70%糖溶液。将所述糖溶液与玉米糖浆、甘油和调味剂混合并加热，以形成液体掺合物。Prepare a 70% sugar solution. The sugar solution is mixed with corn syrup, glycerin, and flavoring and heated to form a liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的烟草材料与盐、三氯蔗糖和粘合剂材料（阿拉伯树胶）混合。将所述液体掺合物加入含有烟草和粘合剂材料的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm混合所述成分约4-5分钟，以形成无烟烟草组合物。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约28份粘合剂材料、30.7份烟草材料、32.7份糖溶液、3.5份玉米糖浆、2.1份甘油、1.8份盐、0.2份三氯蔗糖、和1份调味剂。In a Hobart mixing bowl, tobacco material having an average particle size of less than about 100 microns is mixed with salt, sucralose, and binder material (gum arabic). The liquid blend was added to a Hobart mixing bowl containing tobacco and binder material, wherein the ingredients were mixed in a Hobart mixer (Model N-50) at about 120 rpm for about 4-5 minutes to form a smokeless Tobacco composition. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The mixture of the smokeless tobacco composition is about 28 parts binder material, 30.7 parts tobacco material, 32.7 parts sugar solution, 3.5 parts corn syrup, 2.1 parts glycerin, 1.8 parts salt, 0.2 parts sucralose, and 1 part Flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例2Example 2

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

制备70%糖溶液。将所述糖溶液与乳化剂（可作为DUR-EM117得自 LodersCroklaan）、玉米糖浆、甘油和调味剂混合并加热，以形成液体掺合物。Prepare a 70% sugar solution. The sugar solution is mixed with an emulsifier (available as DUR-EM117 from Loders Croklaan), corn syrup, glycerin and flavoring and heated to form a liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的烟草材料与盐、三氯蔗糖和粘合剂材料（阿拉伯树胶）混合。将所述液体掺合物加入含有烟草和粘合剂材料的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm混合所述成分约4-5分钟，以形成无烟烟草组合物。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约28份粘合剂材料、30.7份烟草材料、0.5份乳化剂、32.1份糖溶液、 3.5份玉米糖浆、2.1份甘油、1.8份盐、0.2份三氯蔗糖和1份调味剂。In a Hobart mixing bowl, tobacco material having an average particle size of less than about 100 microns is mixed with salt, sucralose, and binder material (gum arabic). The liquid blend was added to a Hobart mixing bowl containing tobacco and binder material, wherein the ingredients were mixed in a Hobart mixer (Model N-50) at about 120 rpm for about 4-5 minutes to form a smokeless Tobacco composition. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The mixture of the smokeless tobacco composition is about 28 parts binder material, 30.7 parts tobacco material, 0.5 parts emulsifier, 32.1 parts sugar solution, 3.5 parts corn syrup, 2.1 parts glycerin, 1.8 parts salt, 0.2 parts trichloro cane sugar and 1 part flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例3Example 3

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

混合并加热填充剂（山梨醇）、乳化剂（可作为DUR-EM117得自Loders Croklaan）、玉米糖浆、甘油和调味剂，以形成液体掺合物。Bulking agent (sorbitol), emulsifier (available as DUR-EM117 from Loders Croklaan), corn syrup, glycerin and flavoring are mixed and heated to form a liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与盐、三氯蔗糖和粘合剂材料（阿拉伯树胶）混合。将所述液体掺合物加入含有烟草材料掺合物和粘合剂材料的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm混合所述成分约4-5分钟，以形成无烟烟草组合物。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约28份粘合剂材料、30.6份烟草材料、28份填充剂、5份乳化剂、3.5份玉米糖浆、2.1份甘油、1.8份盐、0.2份三氯蔗糖和0.8份调味剂。A tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was mixed with salt, sucralose, and binder material (gum arabic) in a Hobart mixing bowl. The liquid blend was added to a Hobart mixing bowl containing the tobacco material blend and binder material, wherein the ingredients were mixed in a Hobart mixer (Model N-50) at about 120 rpm for about 4-5 minutes, to form a smokeless tobacco composition. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The blend of the smokeless tobacco composition is about 28 parts binder material, 30.6 parts tobacco material, 28 parts filler, 5 parts emulsifier, 3.5 parts corn syrup, 2.1 parts glycerin, 1.8 parts salt, 0.2 parts trichloro Sucrose and 0.8 parts flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例4Example 4

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

混合并加热填充剂（麦芽糖醇；可作为LYCASIN从Roquette Frères S.A. 得到）、乳化剂（可作为DUR-EM117得自Loders Croklaan）、玉米糖浆、甘油和调味剂，以形成液体掺合物。Bulking agent (maltitol; available as LYCASIN from Roquette Frères S.A.), emulsifier (available as DUR-EM117 from Loders Croklaan), corn syrup, glycerin, and flavoring are mixed and heated to form a liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与盐、三氯蔗糖和粘合剂材料（阿拉伯树胶）混合。将所述液体掺合物加入含有烟草材料掺合物和粘合剂材料的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm混合所述成分约4-5分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart 混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约27.2份粘合剂材料、29.6份烟草材料、27.2份填充剂、7.8份乳化剂、3.4份玉米糖浆、2 份甘油、1.7份盐、0.2份三氯蔗糖和0.8份调味剂。A tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was mixed with salt, sucralose, and binder material (gum arabic) in a Hobart mixing bowl. The liquid blend was added to a Hobart mixing bowl containing the tobacco material blend and binder material, wherein the ingredients were mixed in a Hobart mixer (Model N-50) at about 120 rpm for about 4-5 minutes, to form a smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The blend of the smokeless tobacco composition is about 27.2 parts binder material, 29.6 parts tobacco material, 27.2 parts filler, 7.8 parts emulsifier, 3.4 parts corn syrup, 2 parts glycerin, 1.7 parts salt, 0.2 parts trichloro Sucrose and 0.8 parts flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例5Example 5

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

混合并加热填充剂（麦芽糖醇；可作为LYCASIN从Roquette Frères S.A. 得到）、乳化剂（可作为DUR-EM117得自Loders Croklaan）、玉米糖浆、甘油和调味剂，以形成液体掺合物。Bulking agent (maltitol; available as LYCASIN from Roquette Frères S.A.), emulsifier (available as DUR-EM117 from Loders Croklaan), corn syrup, glycerin, and flavoring are mixed and heated to form a liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与盐、三氯蔗糖和粘合剂材料（黄原胶）混合。将所述液体掺合物加入含有烟草材料掺合物和粘合剂材料的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm混合所述成分约4-5 分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约27.2份粘合剂材料、 29.6份烟草材料、27.2份填充剂、7.8份乳化剂、3.4份玉米糖浆、2份甘油、1.7份盐、0.2份三氯蔗糖和0.8份调味剂。A tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was mixed with salt, sucralose, and binder material (xanthan gum) in a Hobart mixing bowl. The liquid blend was added to a Hobart mixing bowl containing the tobacco material blend and binder material, wherein the ingredients were mixed in a Hobart mixer (Model N-50) at about 120 rpm for about 4-5 minutes, to form a smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The blend of the smokeless tobacco composition is about 27.2 parts binder material, 29.6 parts tobacco material, 27.2 parts filler, 7.8 parts emulsifier, 3.4 parts corn syrup, 2 parts glycerin, 1.7 parts salt, 0.2 parts trichloro Sucrose and 0.8 parts flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例6Example 6

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

混合并加热填充剂（麦芽糖醇；可作为LYCASIN从Roquette Frères S.A. 得到）、乳化剂（可作为DUR-EM117得自Loders Croklaan）、玉米糖浆、甘油和调味剂，以形成液体掺合物。Bulking agent (maltitol; available as LYCASIN from Roquette Frères S.A.), emulsifier (available as DUR-EM117 from Loders Croklaan), corn syrup, glycerin, and flavoring are mixed and heated to form a liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与盐、三氯蔗糖和粘合剂材料（可作为NYMCEL ZSX-W 得自CP Kelco）混合。将所述液体掺合物加入含有烟草材料掺合物和粘合剂材料的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约 120rpm混合所述成分约4-5分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约27.2份粘合剂材料、29.6份烟草材料、27.2份填充剂、7.8份乳化剂、3.4份玉米糖浆、2份甘油、1.7份盐、0.2份三氯蔗糖和0.8份调味剂。In a Hobart mixing bowl, a tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was mixed with salt, sucralose, and binder material (available as NYMCEL ZSX-W from CP Kelco) . The liquid blend was added to a Hobart mixing bowl containing the tobacco material blend and binder material, wherein the ingredients were mixed in a Hobart mixer (Model N-50) at about 120 rpm for about 4-5 minutes, to form a smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The blend of the smokeless tobacco composition is about 27.2 parts binder material, 29.6 parts tobacco material, 27.2 parts filler, 7.8 parts emulsifier, 3.4 parts corn syrup, 2 parts glycerin, 1.7 parts salt, 0.2 parts trichloro Sucrose and 0.8 parts flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例7Example 7

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

混合并加热填充剂（麦芽糖醇；可作为LYCASIN从Roquette Frères S.A. 得到）、乳化剂（可作为DUR-EM117得自Loders Croklaan）、玉米糖浆、甘油和调味剂，以形成液体掺合物。Bulking agent (maltitol; available as LYCASIN from Roquette Frères S.A.), emulsifier (available as DUR-EM117 from Loders Croklaan), corn syrup, glycerin, and flavoring are mixed and heated to form a liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与盐、三氯蔗糖和粘合剂材料（结冷胶）混合。将所述液体掺合物加入含有烟草材料掺合物和粘合剂材料的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm混合所述成分约4-5 分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约27.2份粘合剂材料、 29.6份烟草材料、27.2份填充剂、7.8份乳化剂、3.4份玉米糖浆、2份甘油、1.7份盐、0.2份三氯蔗糖和0.8份调味剂。A tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was mixed with salt, sucralose, and binder material (gellan gum) in a Hobart mixing bowl. The liquid blend was added to a Hobart mixing bowl containing the tobacco material blend and binder material, wherein the ingredients were mixed in a Hobart mixer (Model N-50) at about 120 rpm for about 4-5 minutes, to form a smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The blend of the smokeless tobacco composition is about 27.2 parts binder material, 29.6 parts tobacco material, 27.2 parts filler, 7.8 parts emulsifier, 3.4 parts corn syrup, 2 parts glycerin, 1.7 parts salt, 0.2 parts trichloro Sucrose and 0.8 parts flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例8Example 8

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

混合并加热填充剂（麦芽糖醇；可作为LYCASIN从Roquette Frères S.A. 得到）、乳化剂（可作为DUR-EM117得自Loders Croklaan）、玉米糖浆、甘油和调味剂，以形成液体掺合物。Bulking agent (maltitol; available as LYCASIN from Roquette Frères S.A.), emulsifier (available as DUR-EM117 from Loders Croklaan), corn syrup, glycerin, and flavoring are mixed and heated to form a liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与盐、三氯蔗糖和粘合剂材料（阿拉伯树胶）混合。将所述液体掺合物加入含有烟草材料掺合物和粘合剂材料的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm混合所述成分约4-5分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart 混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约29.2份粘合剂材料、31.8份烟草材料、29.2份填充剂、1份乳化剂、3.6份玉米糖浆、2.2 份甘油、1.9份盐、0.2份三氯蔗糖和0.8份调味剂。A tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was mixed with salt, sucralose, and binder material (gum arabic) in a Hobart mixing bowl. The liquid blend was added to a Hobart mixing bowl containing the tobacco material blend and binder material, wherein the ingredients were mixed in a Hobart mixer (Model N-50) at about 120 rpm for about 4-5 minutes, to form a smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The blend of the smokeless tobacco composition is about 29.2 parts binder material, 31.8 parts tobacco material, 29.2 parts filler, 1 part emulsifier, 3.6 parts corn syrup, 2.2 parts glycerin, 1.9 parts salt, 0.2 parts trichloro Sucrose and 0.8 parts flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例9Example 9

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

混合并加热湿润剂（可作为HYSTAR3375得自Corn Products International）、乳化剂（可作为DUR-EM117得自Loders Croklaan）、玉米糖浆、甘油和调味剂，以形成液体掺合物。Wetting agent (available as HYSTAR 3375 from Corn Products International), emulsifier (available as DUR-EM117 from Loders Croklaan), corn syrup, glycerin, and flavoring are mixed and heated to form a liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与盐、三氯蔗糖、粘合剂材料（阿拉伯树胶）和聚葡萄糖粉末（可作为LITESSE得自Danisco A/S）混合。将所述液体掺合物加入含有烟草材料掺合物、粘合剂材料和聚葡萄糖粉末的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm混合所述成分约4-5分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart 混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约14.6份粘合剂材料、31.8份烟草材料、29.2份湿润剂、1份乳化剂、14.6份聚葡萄糖、3.6 份玉米糖浆、2.2份甘油、1.9份盐、0.2份三氯蔗糖和0.8份调味剂。In a Hobart mixing bowl, a tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was mixed with salt, sucralose, binder material (gum arabic) and polydextrose powder (available as LITESSE Mixed from Danisco A/S). The liquid blend was added to a Hobart mixing bowl containing tobacco material blend, binder material and polydextrose powder, wherein the ingredients were mixed in a Hobart mixer (Model N-50) at about 120 rpm for about 4 - 5 minutes to form a smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The blend of the smokeless tobacco composition is about 14.6 parts binder material, 31.8 parts tobacco material, 29.2 parts humectant, 1 part emulsifier, 14.6 parts polydextrose, 3.6 parts corn syrup, 2.2 parts glycerin, 1.9 parts salt , 0.2 parts sucralose and 0.8 parts flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例10Example 10

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

混合并加热填充剂（麦芽糖醇；可作为LYCASIN从Roquette Frères S.A. 得到）、乳化剂（可作为DUR-EM117得自Loders Croklaan）、玉米糖浆、甘油和调味剂，以形成液体掺合物。Bulking agent (maltitol; available as LYCASIN from Roquette Frères S.A.), emulsifier (available as DUR-EM117 from Loders Croklaan), corn syrup, glycerin, and flavoring are mixed and heated to form a liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与盐、三氯蔗糖、粘合剂材料（阿拉伯树胶）和多糖（麦芽糊精；可作为MALTRINM100得自Grain Processing Corporation）混合。将所述液体掺合物加入含有烟草材料掺合物、粘合剂材料和多糖的 Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm 混合所述成分约4-5分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约 14.6份粘合剂材料、31.8份烟草材料、14.6份多糖、29.2份填充剂、1 份乳化剂、3.6份玉米糖浆、2.2份甘油、1.9份盐、0.2份三氯蔗糖和0.8 份调味剂。In a Hobart mixing bowl, a tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns is mixed with salt, sucralose, binder material (gum arabic) and polysaccharide (maltodextrin; available as MALTRIN M100 from Grain Processing Corporation) was mixed. The liquid blend was added to a Hobart mixing bowl containing tobacco material blend, binder material and polysaccharide, wherein the ingredients were mixed in a Hobart mixer (Model N-50) at about 120 rpm for about 4-5 minutes to form a smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The blend of the smokeless tobacco composition is about 14.6 parts binder material, 31.8 parts tobacco material, 14.6 parts polysaccharide, 29.2 parts filler, 1 part emulsifier, 3.6 parts corn syrup, 2.2 parts glycerin, 1.9 parts salt, 0.2 parts sucralose and 0.8 parts flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例11Example 11

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

混合并加热填充剂（麦芽糖醇；可作为LYCASIN从Roquette Frères S.A. 得到）、乳化剂（可作为DUR-EM117得自Loders Croklaan）、玉米糖浆、甘油和调味剂，以形成液体掺合物。Bulking agent (maltitol; available as LYCASIN from Roquette Frères S.A.), emulsifier (available as DUR-EM117 from Loders Croklaan), corn syrup, glycerin, and flavoring are mixed and heated to form a liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与盐、三氯蔗糖、粘合剂材料（阿拉伯树胶）和多糖（普鲁兰多糖粉末）混合。将所述液体掺合物加入含有烟草材料掺合物、粘合剂材料和多糖的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm混合所述成分约4-5分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约14.6份粘合剂材料、31.8份烟草材料、14.6份多糖、29.2 份填充剂、1份乳化剂、3.6份玉米糖浆、2.2份甘油、1.9份盐、0.2份三氯蔗糖和0.8份调味剂。A tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was combined with salt, sucralose, binder material (gum arabic) and polysaccharide (pullulan powder) in a Hobart mixing bowl mix. The liquid blend was added to a Hobart mixing bowl containing tobacco material blend, binder material and polysaccharide, wherein the ingredients were mixed in a Hobart mixer (Model N-50) at about 120 rpm for about 4-5 minutes to form a smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The blend of the smokeless tobacco composition is about 14.6 parts binder material, 31.8 parts tobacco material, 14.6 parts polysaccharide, 29.2 parts filler, 1 part emulsifier, 3.6 parts corn syrup, 2.2 parts glycerin, 1.9 parts salt, 0.2 parts sucralose and 0.8 parts flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例12Example 12

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

混合并加热湿润剂（可作为HYSTAR3375得自Corn Products International）、乳化剂（可作为DUR-EM117得自Loders Croklaan）、玉米糖浆、甘油和调味剂，以形成液体掺合物。Wetting agent (available as HYSTAR 3375 from Corn Products International), emulsifier (available as DUR-EM117 from Loders Croklaan), corn syrup, glycerin, and flavoring are mixed and heated to form a liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与盐、三氯蔗糖、粘合剂材料（阿拉伯树胶）和聚葡萄糖粉末（可作为LITESSE得自Danisco A/S）混合。将所述液体掺合物加入含有烟草材料掺合物、粘合剂材料和聚葡萄糖粉末的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm混合所述成分约4-5分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart 混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约15.1份粘合剂材料、32.9份烟草材料、26.9份湿润剂、1.1份乳化剂、15.1份聚葡萄糖、 3.8份玉米糖浆、2.3份甘油、1.9份盐、0.2份三氯蔗糖和0.9份调味剂。In a Hobart mixing bowl, a tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was mixed with salt, sucralose, binder material (gum arabic) and polydextrose powder (available as LITESSE Mixed from Danisco A/S). The liquid blend was added to a Hobart mixing bowl containing tobacco material blend, binder material and polydextrose powder, wherein the ingredients were mixed in a Hobart mixer (Model N-50) at about 120 rpm for about 4 - 5 minutes to form a smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The blend of the smokeless tobacco composition is about 15.1 parts binder material, 32.9 parts tobacco material, 26.9 parts humectant, 1.1 parts emulsifier, 15.1 parts polydextrose, 3.8 parts corn syrup, 2.3 parts glycerin, 1.9 parts salt , 0.2 parts sucralose and 0.9 parts flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例13Example 13

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

混合湿润剂（可作为HYSTAR3375得自Corn Products International）、乳化剂（可作为DUR-EM117得自Loders Croklaan）、植物蛋白（可得自 Freeman Industries LLC）、玉米糖浆和甘油，以形成液体掺合物。将所述液体掺合物加热至约54℃。将调味剂加入经过加热的液体掺合物中。Mix humectant (available as HYSTAR3375 from Corn Products International), emulsifier (available as DUR-EM117 from Loders Croklaan), vegetable protein (available from Freeman Industries LLC), corn syrup, and glycerin to form a liquid blend . The liquid blend was heated to about 54°C. Flavorings are added to the heated liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与粘合剂材料（阿拉伯树胶）、盐、甜味剂（三氯蔗糖）和聚葡萄糖粉末（可作为LITESSE得自Danisco A/S）混合。将所述液体掺合物加入含有烟草材料掺合物、粘合剂材料、盐、甜味剂和聚葡萄糖粉末的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm 混合所述成分约4-5分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约 11.1份粘合剂材料、31.8份烟草材料、29.2份湿润剂、1份乳化剂、3.5 份植物蛋白、14.6份聚葡萄糖、3.6份玉米糖浆、2.2份甘油、1.9份盐、 0.2份三氯蔗糖和0.8份调味剂。In a Hobart mixing bowl, a tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was combined with binder material (gum arabic), salt, sweetener (sucralose) and polydextrose powder (available as LITESSE from Danisco A/S) mixed. The liquid blend was added to a Hobart mixing bowl containing tobacco material blend, binder material, salt, sweetener and polydextrose powder in a Hobart mixer (Model N-50) at about 120rpm The ingredients are mixed for about 4-5 minutes to form the smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The blend of the smokeless tobacco composition is about 11.1 parts binder material, 31.8 parts tobacco material, 29.2 parts humectant, 1 part emulsifier, 3.5 parts vegetable protein, 14.6 parts polydextrose, 3.6 parts corn syrup, 2.2 parts Glycerin, 1.9 parts salt, 0.2 parts sucralose, and 0.8 parts flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例14Example 14

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

将植物蛋白（可得自Freeman Industries LLC）与水混合。混合湿润剂（可作为HYSTAR3375得自Corn Products International）、乳化剂（可作为DUR-EM117得自LodersCroklaan）、玉米糖浆、甘油和水合的植物蛋白，以形成液体掺合物。将所述液体掺合物加热至约54℃。将调味剂加入经过加热的液体掺合物中。Mix vegetable protein (available from Freeman Industries LLC) with water. Wetting agent (available as HYSTAR 3375 from Corn Products International), emulsifier (available as DUR-EM117 from Loders Croklaan), corn syrup, glycerin and hydrated vegetable protein are mixed to form a liquid blend. The liquid blend was heated to about 54°C. Flavorings are added to the heated liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与粘合剂材料（阿拉伯树胶）、盐、甜味剂（三氯蔗糖）和聚葡萄糖粉末（可作为LITESSE得自Danisco A/S）混合。将所述液体掺合物加入含有烟草材料掺合物、粘合剂材料、盐、甜味剂和聚葡萄糖粉末的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm 混合所述成分约4-5分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约9.9份粘合剂材料、28.4份烟草材料、26份湿润剂、0.9份乳化剂、3.3 份植物蛋白、10.6份水、13份聚葡萄糖、3.3份玉米糖浆、2份甘油、1.7 份盐、0.2份三氯蔗糖和0.7份调味剂。In a Hobart mixing bowl, a tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was combined with binder material (gum arabic), salt, sweetener (sucralose) and polydextrose powder (available as LITESSE from Danisco A/S) mixed. The liquid blend was added to a Hobart mixing bowl containing tobacco material blend, binder material, salt, sweetener and polydextrose powder in a Hobart mixer (Model N-50) at about 120rpm The ingredients are mixed for about 4-5 minutes to form the smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The blend of the smokeless tobacco composition is about 9.9 parts binder material, 28.4 parts tobacco material, 26 parts humectant, 0.9 part emulsifier, 3.3 parts vegetable protein, 10.6 parts water, 13 parts polydextrose, 3.3 parts corn Syrup, 2 parts glycerin, 1.7 parts salt, 0.2 parts sucralose and 0.7 parts flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例15Example 15

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

混合湿润剂（可作为HYSTAR3375得自Corn Products International）、乳化剂（可作为DUR-EM117得自Loders Croklaan）、植物蛋白（可得自 Freeman Industries LLC）、玉米糖浆和甘油，以形成液体掺合物。将所述液体掺合物加热至约54℃。将调味剂加入经过加热的液体掺合物中。Mix humectant (available as HYSTAR3375 from Corn Products International), emulsifier (available as DUR-EM117 from Loders Croklaan), vegetable protein (available from Freeman Industries LLC), corn syrup, and glycerin to form a liquid blend . The liquid blend was heated to about 54°C. Flavorings are added to the heated liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与粘合剂材料（阿拉伯树胶）、盐、甜味剂（三氯蔗糖）和聚葡萄糖粉末（可作为LITESSE得自Danisco A/S）混合。将所述液体掺合物加入含有烟草材料掺合物、粘合剂材料、盐、甜味剂和聚葡萄糖粉末的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm 混合所述成分约4-5分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约 10.7份粘合剂材料、30.7份烟草材料、28.1份湿润剂、1份乳化剂、6.9 份植物蛋白、14.1份聚葡萄糖、3.5份玉米糖浆、2.1份甘油、1.8份盐、 0.2份三氯蔗糖和0.8份调味剂。In a Hobart mixing bowl, a tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was combined with binder material (gum arabic), salt, sweetener (sucralose) and polydextrose powder (available as LITESSE from Danisco A/S) mixed. The liquid blend was added to a Hobart mixing bowl containing tobacco material blend, binder material, salt, sweetener and polydextrose powder in a Hobart mixer (Model N-50) at about 120rpm The ingredients are mixed for about 4-5 minutes to form the smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The blend of the smokeless tobacco composition is about 10.7 parts binder material, 30.7 parts tobacco material, 28.1 parts humectant, 1 part emulsifier, 6.9 parts vegetable protein, 14.1 parts polydextrose, 3.5 parts corn syrup, 2.1 parts Glycerin, 1.8 parts salt, 0.2 parts sucralose and 0.8 parts flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例16Example 16

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

混合湿润剂（可作为HYSTAR3375得自Corn Products International）、乳化剂（可作为DUR-EM117得自Loders Croklaan）、植物蛋白（可得自 Freeman Industries LLC）、玉米糖浆和甘油，以形成液体掺合物。将所述液体掺合物加热至约54℃。将调味剂加入经过加热的液体掺合物中。Mix humectant (available as HYSTAR3375 from Corn Products International), emulsifier (available as DUR-EM117 from Loders Croklaan), vegetable protein (available from Freeman Industries LLC), corn syrup, and glycerin to form a liquid blend . The liquid blend was heated to about 54°C. Flavorings are added to the heated liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与粘合剂材料（阿拉伯树胶）、盐、甜味剂（三氯蔗糖）和聚葡萄糖粉末（可作为LITESSE得自Danisco A/S）混合。将所述液体掺合物加入含有烟草材料掺合物、粘合剂材料、盐、甜味剂和聚葡萄糖粉末的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm 混合所述成分约4-5分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约 11.2份粘合剂材料、32.3份烟草材料、24.6份湿润剂、1.1份乳化剂、7.2 份植物蛋白、14.8份聚葡萄糖、3.7份玉米糖浆、2.2份甘油、1.9份盐、 0.2份三氯蔗糖和0.8份调味剂。In a Hobart mixing bowl, a tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was combined with binder material (gum arabic), salt, sweetener (sucralose) and polydextrose powder (available as LITESSE from Danisco A/S) mixed. The liquid blend was added to a Hobart mixing bowl containing tobacco material blend, binder material, salt, sweetener and polydextrose powder in a Hobart mixer (Model N-50) at about 120rpm The ingredients are mixed for about 4-5 minutes to form the smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The blend of the smokeless tobacco composition is about 11.2 parts binder material, 32.3 parts tobacco material, 24.6 parts humectant, 1.1 parts emulsifier, 7.2 parts vegetable protein, 14.8 parts polydextrose, 3.7 parts corn syrup, 2.2 parts Glycerin, 1.9 parts salt, 0.2 parts sucralose, and 0.8 parts flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例17Example 17

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

将植物蛋白（可得自Freeman Industries LLC）与水混合。混合湿润剂（可作为HYSTAR3375得自Corn Products International）、乳化剂（可作为DUR-EM117得自LodersCroklaan）、玉米糖浆、甘油和水合的植物蛋白，以形成液体掺合物。将所述液体掺合物加热至约54℃。将调味剂加入经过加热的液体掺合物中。Mix vegetable protein (available from Freeman Industries LLC) with water. Wetting agent (available as HYSTAR 3375 from Corn Products International), emulsifier (available as DUR-EM117 from Loders Croklaan), corn syrup, glycerin and hydrated vegetable protein are mixed to form a liquid blend. The liquid blend was heated to about 54°C. Flavorings are added to the heated liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与粘合剂材料（阿拉伯树胶）、盐、甜味剂（三氯蔗糖）和聚葡萄糖粉末（可作为LITESSE得自Danisco A/S）混合。将所述液体掺合物加入含有烟草材料掺合物、粘合剂材料、盐、甜味剂和聚葡萄糖粉末的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm 混合所述成分约4-5分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约 9.9份粘合剂材料、28.4份烟草材料、26份湿润剂、0.9份乳化剂、6.5 份植物蛋白、21.3份水、13份聚葡萄糖、3.3份玉米糖浆、2份甘油、1.7 份盐、0.2份三氯蔗糖和0.7份调味剂。In a Hobart mixing bowl, a tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was combined with binder material (gum arabic), salt, sweetener (sucralose) and polydextrose powder (available as LITESSE from Danisco A/S) mixed. The liquid blend was added to a Hobart mixing bowl containing tobacco material blend, binder material, salt, sweetener and polydextrose powder in a Hobart mixer (Model N-50) at about 120rpm The ingredients are mixed for about 4-5 minutes to form the smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The blend of the smokeless tobacco composition is about 9.9 parts binder material, 28.4 parts tobacco material, 26 parts humectant, 0.9 part emulsifier, 6.5 parts vegetable protein, 21.3 parts water, 13 parts polydextrose, 3.3 parts corn Syrup, 2 parts glycerin, 1.7 parts salt, 0.2 parts sucralose and 0.7 parts flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例18Example 18

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

混合湿润剂（可作为HYSTAR3375得自Corn Products International）、乳化剂（可作为DUR-EM117得自Loders Croklaan）、植物蛋白（可得自 Freeman Industries LLC）、玉米糖浆和甘油，以形成液体掺合物。将所述液体掺合物加热至约54℃。将调味剂加入经过加热的液体掺合物中。Mix humectant (available as HYSTAR3375 from Corn Products International), emulsifier (available as DUR-EM117 from Loders Croklaan), vegetable protein (available from Freeman Industries LLC), corn syrup, and glycerin to form a liquid blend . The liquid blend was heated to about 54°C. Flavorings are added to the heated liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与粘合剂材料（阿拉伯树胶）、盐、甜味剂（三氯蔗糖）和聚葡萄糖粉末（可作为LITESSE得自Danisco A/S）混合。将所述液体掺合物加入含有烟草材料掺合物、粘合剂材料、盐、甜味剂和聚葡萄糖粉末的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm 混合所述成分约4-5分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约 11.2份粘合剂材料、32.3份烟草材料、24.6份湿润剂、1.1份乳化剂、4.6 份植物蛋白、14.8份聚葡萄糖、3.7份玉米糖浆、2.2份甘油、1.9份盐、 0.2份三氯蔗糖和0.8份调味剂。In a Hobart mixing bowl, a tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was combined with binder material (gum arabic), salt, sweetener (sucralose) and polydextrose powder (available as LITESSE from Danisco A/S) mixed. The liquid blend was added to a Hobart mixing bowl containing tobacco material blend, binder material, salt, sweetener and polydextrose powder in a Hobart mixer (Model N-50) at about 120rpm The ingredients are mixed for about 4-5 minutes to form the smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The blend of the smokeless tobacco composition is about 11.2 parts binder material, 32.3 parts tobacco material, 24.6 parts humectant, 1.1 parts emulsifier, 4.6 parts vegetable protein, 14.8 parts polydextrose, 3.7 parts corn syrup, 2.2 parts Glycerin, 1.9 parts salt, 0.2 parts sucralose, and 0.8 parts flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例19Example 19

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

将具有约275的bloom值的明胶（鱼）与水混合。混合湿润剂（可作为HYSTAR3375得自Corn Products International）、乳化剂（可作为 DUR-EM117得自Loders Croklaan）、玉米糖浆和甘油，以形成液体掺合物。将所述液体掺合物加热至约110℃。将水合的明胶和调味剂加入经过加热的液体掺合物中。Mix gelatin (fish) with a bloom value of about 275 with water. Wetting agent (available as HYSTAR3375 from Corn Products International), emulsifier (available as DUR-EM117 from Loders Croklaan), corn syrup and glycerin are mixed to form a liquid blend. The liquid blend was heated to about 110°C. Hydrated gelatin and flavoring are added to the heated liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与粘合剂材料（阿拉伯树胶）、盐、甜味剂（三氯蔗糖）和聚葡萄糖粉末（可作为LITESSE得自Danisco A/S）混合。将所述液体掺合物加入含有烟草材料掺合物、粘合剂材料、盐、甜味剂和聚葡萄糖粉末的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm 混合所述成分约4-5分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约 9.8份粘合剂材料、28份烟草材料、25.6份湿润剂、0.9份乳化剂、7.6 份明胶、7.6份水、12.8份聚葡萄糖、3.2份玉米糖浆、1.9份甘油、1.6 份盐、0.2份三氯蔗糖和0.7份调味剂。In a Hobart mixing bowl, a tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was combined with binder material (gum arabic), salt, sweetener (sucralose) and polydextrose powder (available as LITESSE from Danisco A/S) mixed. The liquid blend was added to a Hobart mixing bowl containing tobacco material blend, binder material, salt, sweetener and polydextrose powder in a Hobart mixer (Model N-50) at about 120rpm The ingredients are mixed for about 4-5 minutes to form the smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The mixture of the smokeless tobacco composition is about 9.8 parts binder material, 28 parts tobacco material, 25.6 parts humectant, 0.9 parts emulsifier, 7.6 parts gelatin, 7.6 parts water, 12.8 parts polydextrose, 3.2 parts corn syrup , 1.9 parts of glycerin, 1.6 parts of salt, 0.2 parts of sucralose and 0.7 parts of flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例20Example 20

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

将具有约275的bloom值的明胶（鱼）与水混合。混合湿润剂（可作为HYSTAR3375得自Corn Products International）、乳化剂（可作为 DUR-EM117得自Loders Croklaan）、玉米糖浆和甘油，以形成液体掺合物。将所述液体掺合物加热至约110℃。将水合的明胶和调味剂加入经过加热的液体掺合物中。Mix gelatin (fish) with a bloom value of about 275 with water. Wetting agent (available as HYSTAR3375 from Corn Products International), emulsifier (available as DUR-EM117 from Loders Croklaan), corn syrup and glycerin are mixed to form a liquid blend. The liquid blend was heated to about 110°C. Hydrated gelatin and flavoring are added to the heated liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与粘合剂材料（阿拉伯树胶）、盐、甜味剂（三氯蔗糖）和聚葡萄糖粉末（可作为LITESSE得自Danisco A/S）混合。将所述液体掺合物加入含有烟草材料掺合物、粘合剂材料、盐、甜味剂和聚葡萄糖粉末的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm 混合所述成分约4-5分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约 10.4份粘合剂材料、27.8份烟草材料、27.3份湿润剂、1份乳化剂、4.9 份明胶、4.9份水、13.6份聚葡萄糖、3.4份玉米糖浆、2份甘油、1.8份盐、0.2份三氯蔗糖和0.8份调味剂。In a Hobart mixing bowl, a tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was combined with binder material (gum arabic), salt, sweetener (sucralose) and polydextrose powder (available as LITESSE from Danisco A/S) mixed. The liquid blend was added to a Hobart mixing bowl containing tobacco material blend, binder material, salt, sweetener and polydextrose powder in a Hobart mixer (Model N-50) at about 120rpm The ingredients are mixed for about 4-5 minutes to form the smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The mixture of the smokeless tobacco composition is about 10.4 parts binder material, 27.8 parts tobacco material, 27.3 parts humectant, 1 part emulsifier, 4.9 parts gelatin, 4.9 parts water, 13.6 parts polydextrose, 3.4 parts corn syrup , 2 parts glycerin, 1.8 parts salt, 0.2 parts sucralose and 0.8 parts flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

实施例21Example 21

以下述方式提供适合用作用于口服使用的无烟烟草产品的无烟烟草组合物。A smokeless tobacco composition suitable for use as a smokeless tobacco product for oral use is provided in the following manner.

将具有约275的bloom值的明胶（鱼）与水混合。混合湿润剂（可作为HYSTAR3375得自Corn Products International）、乳化剂（可作为DUR-EM117得自Loders Croklaan）、玉米糖浆和甘油，以形成液体掺合物。将所述液体掺合物加热至约143℃。将水合的明胶和调味剂加入经过加热的液体掺合物中。Mix gelatin (fish) with a bloom value of about 275 with water. Wetting agent (available as HYSTAR3375 from Corn Products International), emulsifier (available as DUR-EM117 from Loders Croklaan), corn syrup and glycerin were mixed to form a liquid blend. The liquid blend was heated to about 143°C. Hydrated gelatin and flavoring are added to the heated liquid blend.

在Hobart混合碗中，将具有小于约100微米的平均粒度的两类烟草材料的烟草材料掺合物与粘合剂材料（阿拉伯树胶）、盐、甜味剂（三氯蔗糖）和聚葡萄糖粉末（可作为LITESSE得自Danisco A/S）混合。将所述液体掺合物加入含有烟草材料掺合物、粘合剂材料、盐、甜味剂和聚葡萄糖粉末的Hobart混合碗中，其中在Hobart混合器（Model N-50）中在约120rpm 混合所述成分约4-5分钟，以形成无烟烟草组合物。使所述无烟烟草组合物穿过在Hobart混合器上的磨肉机，以将液体成分掺入干燥成分中。穿过研磨装置挤出所述无烟烟草组合物。在挤出后，将所述无烟烟草组合物放入Hobart混合器中，以形成粉末颗粒。所述无烟烟草组合物的混合物是约 9.8份粘合剂材料、28份烟草材料、27.4份湿润剂、0.9份乳化剂、7.6 份明胶、7.6份水、12.8份聚葡萄糖、3.2份玉米糖浆、1.9份甘油、1.6 份盐、0.2份三氯蔗糖和0.7份调味剂。In a Hobart mixing bowl, a tobacco material blend of two types of tobacco material having an average particle size of less than about 100 microns was combined with binder material (gum arabic), salt, sweetener (sucralose) and polydextrose powder (available as LITESSE from Danisco A/S) mixed. The liquid blend was added to a Hobart mixing bowl containing tobacco material blend, binder material, salt, sweetener and polydextrose powder in a Hobart mixer (Model N-50) at about 120rpm The ingredients are mixed for about 4-5 minutes to form the smokeless tobacco composition. The smokeless tobacco composition was passed through a meat grinder on a Hobart mixer to incorporate the liquid ingredients into the dry ingredients. The smokeless tobacco composition is extruded through a milling device. After extrusion, the smokeless tobacco composition was placed in a Hobart mixer to form powder granules. The mixture of the smokeless tobacco composition is about 9.8 parts binder material, 28 parts tobacco material, 27.4 parts humectant, 0.9 parts emulsifier, 7.6 parts gelatin, 7.6 parts water, 12.8 parts polydextrose, 3.2 parts corn syrup , 1.9 parts of glycerin, 1.6 parts of salt, 0.2 parts of sucralose and 0.7 parts of flavoring.

将粒化的无烟烟草组合物转移至注射模具，并在约103,500kPa压制 1分钟。所述模具是装有所述无烟烟草组合物的不锈钢两片块，然后通过与水压机单元（WabachHydraulic Press,Model12-102T,Serial2201）的啮合进行压制。在环境温度冷却约60分钟以后，从注射模具取出所述无烟烟草组合物。The granulated smokeless tobacco composition was transferred to an injection mold and compressed at about 103,500 kPa for 1 minute. The mold was a two-piece block of stainless steel filled with the smokeless tobacco composition, which was then pressed by engagement with a hydraulic press unit (Wabach Hydraulic Press, Model 12-102T, Serial 2201). After cooling at ambient temperature for about 60 minutes, the smokeless tobacco composition was removed from the injection mold.

具有在前述描述中提供的教导益处的本发明所属领域的技术人员将想到本发明的许多修改和其它实施方案。因此，应当理解，本发明不限于公开的具体实施方案，并且修改和其它实施方案意欲被包括在所附权利要求的范围内。尽管本文使用了具体的术语，但是它们仅仅以一般的且描述性的含义使用，而不用于限制的目的。Many modifications and other embodiments of this invention will come to mind to one skilled in the art to which this invention pertains having the benefit of the teachings provided in the foregoing description. Therefore, it is to be understood that the inventions are not to be limited to the particular embodiments disclosed and that modifications and other embodiments are intended to be included within the scope of the appended claims. Although specific terms are employed herein, they are used in a generic and descriptive sense only and not for purposes of limitation.

Claims (22)

Translated fromChinese
1.一种被构造成用于插入使用者嘴中的、可轻轻咀嚼的无烟烟草组合物，所述无烟烟草组合物包含烟草材料和多糖填充剂组分，其中所述多糖填充剂组分包含聚葡萄糖；其中所述无烟烟草组合物是呈注射模塑锭剂的形式。1. A lightly chewable smokeless tobacco composition configured for insertion into a user's mouth, the smokeless tobacco composition comprising tobacco material and a polysaccharide filler component, wherein the polysaccharide filler The component comprises polydextrose; wherein said smokeless tobacco composition is in the form of an injection molded lozenge.2.根据权利要求1所述的无烟烟草组合物，其中所述无烟烟草组合物包含按干重计10重量％至25重量％的所述多糖填充剂组分。2. The smokeless tobacco composition of claim 1, wherein the smokeless tobacco composition comprises 10% to 25% by dry weight of the polysaccharide filler component.3.根据权利要求1所述的无烟烟草组合物，所述无烟烟草组合物另外包含额外的填充剂组分，所述额外的填充剂组分包括糖醇。3. The smokeless tobacco composition of claim 1 additionally comprising an additional filler component comprising a sugar alcohol.4.根据权利要求3所述的无烟烟草组合物，其中所述额外的填充剂组分是山梨醇。4. The smokeless tobacco composition of claim 3, wherein the additional filler component is sorbitol.5.根据权利要求1所述的无烟烟草组合物，所述无烟烟草组合物另外包含粘合剂，所述粘合剂包含水溶性胶质。5. The smokeless tobacco composition of claim 1, further comprising a binder comprising a water soluble colloid.6.根据权利要求5所述的无烟烟草组合物，其中所述粘合剂是阿拉伯树胶。6. The smokeless tobacco composition of claim 5, wherein the binder is gum arabic.7.根据权利要求1所述的无烟烟草组合物，所述无烟烟草组合物另外包含选自下述的添加剂：调味剂、粘合剂、乳化剂、崩解助剂、湿润剂、及它们的混合物。7. The smokeless tobacco composition of claim 1 further comprising an additive selected from the group consisting of flavoring agents, binders, emulsifiers, disintegration aids, humectants, and their mixture.8.根据权利要求1所述的无烟烟草组合物，其中所述烟草材料具有小于50微米的平均粒度，或小于5％的含水量，或二者。8. The smokeless tobacco composition of claim 1, wherein the tobacco material has an average particle size of less than 50 microns, or a moisture content of less than 5%, or both.9.根据权利要求1所述的无烟烟草组合物，所述无烟烟草组合物包含：9. The smokeless tobacco composition of claim 1 comprising:至少20干重％的烟草材料，基于所述组合物的总重量；at least 20 dry weight percent tobacco material, based on the total weight of the composition;至少10干重％的多糖填充剂组分；at least 10% dry weight polysaccharide filler component;至少10干重％的至少一种粘合剂；at least 10% by dry weight of at least one binder;至少20干重％的至少一种湿润剂；at least 20% by dry weight of at least one humectant;至少1干重％的至少一种乳化剂；at least 1% by dry weight of at least one emulsifier;至少0.1干重％的至少一种甜味剂；和at least 0.1% by dry weight of at least one sweetener; and至少0.5干重％的至少一种调味剂。At least 0.5% by dry weight of at least one flavoring agent.10.一种用于制备可轻轻咀嚼的无烟烟草组合物锭剂的方法，所述锭剂被构造成用于插入使用者嘴中，所述方法包括：10. A method for preparing a light chewable smokeless tobacco composition lozenge configured for insertion into a user's mouth, the method comprising:将烟草材料与粘合剂和多糖填充剂组分混合，以形成无烟烟草混合物，其中所述多糖填充剂组分包含聚葡萄糖；mixing tobacco material with a binder and a polysaccharide filler component to form a smokeless tobacco blend, wherein the polysaccharide filler component comprises polydextrose;注射模塑所述无烟烟草混合物；和injection molding said smokeless tobacco blend; and冷却所述无烟烟草混合物，以形成固化的无烟烟草组合物锭剂。The smokeless tobacco mixture is cooled to form a cured smokeless tobacco composition pastille.11.根据权利要求10所述的方法，其中所述粘合剂包含水溶性胶质。11. The method of claim 10, wherein the binder comprises a water soluble colloid.12.根据权利要求11所述的方法，其中所述粘合剂是阿拉伯树胶。12. The method of claim 11, wherein the binder is gum arabic.13.根据权利要求10所述的方法，其中将烟草材料与粘合剂和多糖填充剂组分混合另外包括：将烟草材料与粘合剂、多糖填充剂组分和额外的填充剂组分混合，以形成无烟烟草混合物。13. The method of claim 10, wherein mixing the tobacco material with the binder and the polysaccharide filler component further comprises: mixing the tobacco material with the binder, the polysaccharide filler component, and an additional filler component , to form a smokeless tobacco blend.14.根据权利要求13所述的方法，其中所述额外的填充剂组分包括糖醇。14. The method of claim 13, wherein the additional filler component comprises a sugar alcohol.15.根据权利要求14所述的方法，其中所述额外的填充剂组分包括山梨醇。15. The method of claim 14, wherein the additional filler component comprises sorbitol.16.根据权利要求10所述的方法，其中所述注射模塑所述无烟烟草混合物的步骤包括：使用至少75,000kPa的挤压力，压制所述无烟烟草混合物。16. The method of claim 10, wherein the step of injection molding the smokeless tobacco blend comprises compressing the smokeless tobacco blend using an extrusion force of at least 75,000 kPa.17.根据权利要求10所述的方法，所述方法另外包括下述步骤：在所述混合步骤之前，将添加剂加入所述烟草材料中，所述添加剂选自：调味剂、乳化剂、崩解助剂、湿润剂、及它们的混合物。17. The method of claim 10, further comprising the step of adding an additive to said tobacco material prior to said mixing step, said additive being selected from the group consisting of flavoring agents, emulsifiers, disintegrating Auxiliaries, wetting agents, and mixtures thereof.18.根据权利要求10所述的方法，其中所述烟草材料具有小于50微米的平均粒度，或小于5％的含水量，或二者。18. The method of claim 10, wherein the tobacco material has an average particle size of less than 50 microns, or a moisture content of less than 5%, or both.19.根据权利要求10所述的方法，所述方法另外包括下述步骤：在所述注射模塑步骤之前，将所述无烟烟草混合物挤出为挤出形式，并在所述注射模塑步骤之前，将挤出形式的无烟烟草混合物研磨成经研磨的形式。19. The method of claim 10, further comprising the step of extruding said smokeless tobacco blend into extruded form prior to said injection molding step, and The extruded form of the smokeless tobacco blend is ground into a ground form prior to the step.20.根据权利要求10所述的方法，其中所述混合步骤包括：形成干燥的掺合物，所述掺合物包含所述烟草材料、所述粘合剂和所述多糖填充剂组分的混合物，和将所述干燥的掺合物与液体组分合并，以形成所述无烟烟草混合物。20. The method of claim 10, wherein the mixing step includes forming a dry blend comprising the tobacco material, the binder, and the polysaccharide filler component. blending, and combining the dry blend with the liquid components to form the smokeless tobacco blend.21.根据权利要求20所述的方法，其中所述干燥的掺合物另外包含盐、甜味剂、或它们的组合。21. The method of claim 20, wherein the dry blend further comprises salt, a sweetener, or a combination thereof.22.根据权利要求20所述的方法，其中所述液体组分包含湿润剂、乳化剂、胶凝剂、糖浆、或它们的组合。22. The method of claim 20, wherein the liquid component comprises a wetting agent, an emulsifying agent, a gelling agent, a syrup, or a combination thereof.
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Families Citing this family (150)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US9763928B2 (en)2012-02-102017-09-19Niconovum Usa, Inc.Multi-layer nicotine-containing pharmaceutical composition
US12285025B2 (en)2012-02-102025-04-29R.J. Reynolds Tobacco CompanyMulti-layer smokeless tobacco composition
US9108784B2 (en)2012-06-292015-08-18R.J. Reynolds Tobacco CompanyDispensing container, packaged product assembly, and related method
US9591875B2 (en)2012-09-212017-03-14R. J. Reynolds Tobacco CompanyFibrous composite tobacco-containing materials
US9386800B2 (en)2012-09-212016-07-12R.J. Reynolds Tobacco CompanyFibrous composite tobacco-containing materials
US11412775B2 (en)2012-10-092022-08-16R.J. Reynolds Tobacco CompanyTobacco-derived composition
US9661876B2 (en)2013-03-142017-05-30R.J. Reynolds Tobacco CompanySugar-enriched extract derived from tobacco
US9301544B2 (en)2013-03-142016-04-05R.J. Reynolds Tobacco CompanyProtein-enriched tobacco-derived composition
EP3732997A3 (en)2013-05-022020-11-11JT International SAVaporisable material and capsule
KR101784081B1 (en)*2013-05-132017-10-10니뽄 다바코 산교 가부시키가이샤Tobacco material, tobacco product to which tobacco material is added, and method for producing tobacco material
EP4613457A2 (en)2013-05-132025-09-10Altria Client Services LLCOral product
US9629391B2 (en)2013-08-082017-04-25R.J. Reynolds Tobacco CompanyTobacco-derived pyrolysis oil
US11503853B2 (en)2013-09-092022-11-22R.J. Reynolds Tobacco CompanySmokeless tobacco composition incorporating a botanical material
US10357054B2 (en)2013-10-162019-07-23R.J. Reynolds Tobacco CompanySmokeless tobacco pastille
US9375033B2 (en)*2014-02-142016-06-28R.J. Reynolds Tobacco CompanyTobacco-containing gel composition
US11080739B2 (en)2014-04-252021-08-03R.J. Reynolds Tobacco CompanyData translator
EP3871515B1 (en)2014-05-272025-04-16R. J. Reynolds Tobacco CompanyNicotine salts, co-crystals, and salt co-crystal complexes
CN105768201A (en)*2014-12-172016-07-20贵州中烟工业有限责任公司Gum base type smoke-free tobacco product and preparation method thereof
US10881133B2 (en)2015-04-162021-01-05R.J. Reynolds Tobacco CompanyTobacco-derived cellulosic sugar
US10869497B2 (en)2015-09-082020-12-22R.J. Reynolds Tobacco CompanyHigh-pressure cold pasteurization of tobacco material
CN114656446A (en)2015-11-252022-06-24R.J.雷诺兹烟草公司Nicotine salts, co-crystals and salt co-crystal complexes
US11612183B2 (en)2015-12-102023-03-28R.J. Reynolds Tobacco CompanyProtein-enriched tobacco composition
US10499684B2 (en)2016-01-282019-12-10R.J. Reynolds Tobacco CompanyTobacco-derived flavorants
US11154087B2 (en)2016-02-022021-10-26R.J. Reynolds Tobacco CompanyMethod for preparing flavorful compounds isolated from black liquor and products incorporating the flavorful compounds
US9795162B2 (en)2016-02-082017-10-24R. J. Reynolds Tobacco CompanySystem for monitoring environmental conditions of a tobacco curing site
US10375984B2 (en)2016-07-182019-08-13R.J. Reynolds Tobacco CompanyNonwoven composite smokeless tobacco product
US11091446B2 (en)2017-03-242021-08-17R.J. Reynolds Tobacco CompanyMethods of selectively forming substituted pyrazines
EP3681865B1 (en)2017-09-052025-09-17R. J. Reynolds Tobacco CompanyNicotine salts, co-crystals, and salt co-crystal complexes
US20190307082A1 (en)2018-04-052019-10-10R.J. Reynolds Tobacco CompanyOriental tobacco production methods
CN109288123B (en)*2018-08-242021-08-20湖南中烟工业有限责任公司 A cooling nozzle stick and cigarette
US12063953B2 (en)2019-09-112024-08-20Nicoventures Trading LimitedMethod for whitening tobacco
CA3150662A1 (en)2019-09-112021-03-18Michael Andrew Zawadzki ALTERNATIVE TOBACCO BLEACHING PROCESSES
US12342847B2 (en)2019-09-112025-07-01Nicoventures Trading LimitedOral product with cellulosic flavor stabilizer
US12213510B2 (en)2019-09-112025-02-04Nicoventures Trading LimitedPouched products with enhanced flavor stability
US11369131B2 (en)2019-09-132022-06-28Nicoventures Trading LimitedMethod for whitening tobacco
WO2021086367A1 (en)2019-10-312021-05-06Nicoventures Trading LimitedOral product and method of manufacture
TW202126192A (en)*2019-11-152021-07-16瑞士商傑太日煙國際股份有限公司Hot pressed tobacco substrate
WO2021116881A1 (en)2019-12-092021-06-17Nicoventures Trading LimitedOral product in a pourous pouch comprising a fleece material
US20210169132A1 (en)2019-12-092021-06-10Nicoventures Trading LimitedOral composition including gels
US11969502B2 (en)2019-12-092024-04-30Nicoventures Trading LimitedOral products
WO2021116919A1 (en)2019-12-092021-06-17Nicoventures Trading LimitedFleece for oral product with releasable component
WO2021116855A1 (en)2019-12-092021-06-17Nicoventures Trading LimitedOral compositions and methods of manufacture
US20210169121A1 (en)2019-12-092021-06-10Nicoventures Trading LimitedLiquid oral composition
US20210169123A1 (en)2019-12-092021-06-10Nicoventures Trading LimitedPouched products with enhanced flavor stability
US20210169890A1 (en)2019-12-092021-06-10Nicoventures Trading LimitedOral composition with polymeric component
EP4072516A1 (en)2019-12-092022-10-19Nicoventures Trading LimitedOral product comprising a cannabinoid
CA3160762A1 (en)2019-12-092021-06-17Anthony Richard GerardiProcess
MX2022007085A (en)2019-12-092022-08-19Nicoventures Trading LtdNanoemulsion for oral use.
WO2021116842A1 (en)2019-12-092021-06-17Nicoventures Trading LimitedOral products with controlled release
CA3159813A1 (en)2019-12-092021-06-17Nicoventures Trading LimitedOral product with dissolvable component
US11883527B2 (en)2019-12-092024-01-30Nicoventures Trading LimitedOral composition and method of manufacture
US11793230B2 (en)2019-12-092023-10-24Nicoventures Trading LimitedOral products with improved binding of active ingredients
US20210169785A1 (en)2019-12-092021-06-10Nicoventures Trading LimitedOral compositions with reduced water activity
WO2021116895A2 (en)2019-12-092021-06-17Nicoventures Trading LimitedStimulus-responsive pouch
WO2021116916A1 (en)2019-12-092021-06-17Nicoventures Trading LimitedOral product with multiple flavors having different release profiles
US20210169783A1 (en)2019-12-092021-06-10Nicoventures Trading LimitedOral products with controlled release
AU2020400347A1 (en)2019-12-092022-07-07Nicoventures Trading LimitedLayered fleece for pouched product
WO2021116823A1 (en)2019-12-092021-06-17Nicoventures Trading LimitedOral product
US12151023B2 (en)2019-12-092024-11-26Nicoventures Trading LimitedOral composition with beet material
US20210169788A1 (en)2019-12-092021-06-10Nicoventures Trading LimitedOral product and method of manufacture
US20210170031A1 (en)2019-12-092021-06-10Nicoventures Trading LimitedOral composition with nanocrystalline cellulose
US11889856B2 (en)2019-12-092024-02-06Nicoventures Trading LimitedOral foam composition
WO2021116854A1 (en)2019-12-092021-06-17Nicoventures Trading LimitedOral products with active ingredient combinations
US12310959B2 (en)2019-12-092025-05-27Nicoventures Trading LimitedOral compositions with reduced water content
WO2021116824A1 (en)2019-12-092021-06-17Nicoventures Trading LimitedOral product comprising a cannabinoid
WO2021116826A1 (en)2019-12-092021-06-17Nicoventures Trading LimitedOral product comprising a cannabinoid
PH12022551255A1 (en)2019-12-092023-11-20Nicoventures Trading LtdOral products
US20210169784A1 (en)2019-12-092021-06-10Nicoventures Trading LimitedBuffered oral compositions
US11617744B2 (en)2019-12-092023-04-04Nico Ventures Trading LimitedMoist oral compositions
US11872231B2 (en)2019-12-092024-01-16Nicoventures Trading LimitedMoist oral product comprising an active ingredient
AU2020400386A1 (en)2019-12-092022-07-07Nicoventures Trading LimitedPouched products with heat sealable binder
US12433321B2 (en)2019-12-092025-10-07Nicoventures Trading LimitedOral composition with beet material
WO2021116856A2 (en)2019-12-092021-06-17Nicoventures Trading LimitedOral products
US12171872B2 (en)2019-12-092024-12-24Nicoventures Trading LimitedOral compositions and methods of manufacture
WO2021116825A1 (en)2019-12-092021-06-17Nicoventures Trading LimitedOral product
US12137723B2 (en)2019-12-092024-11-12Nicoventures Trading LimitedOral products with active ingredient combinations
US11672862B2 (en)2019-12-092023-06-13Nicoventures Trading LimitedOral products with reduced irritation
US20210169126A1 (en)2019-12-092021-06-10Nicoventures Trading LimitedOral composition with salt inclusion
WO2021116865A1 (en)2019-12-092021-06-17Nicoventures Trading LimitedAgents for oral composition
US11826462B2 (en)2019-12-092023-11-28Nicoventures Trading LimitedOral product with sustained flavor release
US20210169137A1 (en)2019-12-092021-06-10Nicoventures Trading LimitedPouched products
US20210169129A1 (en)2019-12-092021-06-10Nicoventures Trading LimitedLipid-containing oral composition
CA3159473A1 (en)2019-12-092021-06-17Savannah JOHNSONFleece for oral product with releasable component
US20210169138A1 (en)2019-12-092021-06-10Nicoventures Trading LimitedFibrous fleece material
KR20220119101A (en)2019-12-192022-08-26쥴 랩스, 인크. Organic based nicotine gel composition
WO2021127101A1 (en)2019-12-192021-06-24Juul Labs, Inc.Metal oxide-based gel nicotine compositions
US11712059B2 (en)*2020-02-242023-08-01Nicoventures Trading LimitedBeaded tobacco material and related method of manufacture
WO2021250516A1 (en)2020-06-082021-12-16Nicoventures Trading LimitedEffervescent oral composition comprising an active ingredient
MX2022015714A (en)2020-06-082023-01-24Nicoventures Trading Ltd ORAL EFFERVESCENT COMPOSITION THAT INCLUDES AN ACTIVE INGREDIENT.
GB202013491D0 (en)2020-08-272020-10-14Nicoventures Holdings LtdOral Product
US11937626B2 (en)2020-09-042024-03-26Nicoventures Trading LimitedMethod for whitening tobacco
EP4210512A1 (en)2020-09-112023-07-19Nicoventures Trading LimitedAlginate-based substrates
US20240008522A1 (en)2020-11-182024-01-11Nicoventures Trading LimitedOral products
US11839602B2 (en)2020-11-252023-12-12Nicoventures Trading LimitedOral cannabinoid product with lipid component
EP4304568A1 (en)2021-03-092024-01-17Nicoventures Trading LimitedOral products and methods of manufacture
MX2023010739A (en)2021-03-122023-09-20Nicoventures Trading LtdOral products with self-emulsifying system.
US20220354785A1 (en)2021-04-222022-11-10Nicoventures Trading LimitedOral lozenge products
WO2022224200A1 (en)2021-04-222022-10-27Nicoventures Trading LimitedOral compositions and methods of manufacture
US20220346436A1 (en)2021-04-222022-11-03Nicoventures Trading LimitedOrally dissolving films
CA3216322A1 (en)2021-04-222022-10-27Nicoventures Trading LimitedEffervescent oral composition
WO2022229929A1 (en)2021-04-302022-11-03Nicoventures Trading LimitedOral products with high-density load
US20220354155A1 (en)2021-04-302022-11-10Nicoventures Trading LimitedMulti-compartment oral pouched product
CA3217959A1 (en)2021-05-062022-11-10Matthew D. SAINOral compositions and related methods for reducing throat irritation
EP4355121A1 (en)2021-06-162024-04-24Nicoventures Trading LimitedPouched product comprising dissolvable composition
WO2022264355A1 (en)*2021-06-172022-12-22日本たばこ産業株式会社Flavor molded article and production method therefor, tobacco material production method, and tobacco product production method
WO2022269475A1 (en)2021-06-212022-12-29Nicoventures Trading LimitedOral product tablet and method of manufacture
EP4358748A1 (en)2021-06-252024-05-01Nicoventures Trading LimitedOral products and method of manufacture
JP2024527568A (en)2021-07-092024-07-25ニコベンチャーズ トレーディング リミテッド Extruded Structure
EP4373311A1 (en)2021-07-222024-05-29Nicoventures Trading LimitedNanoemulsion comprising cannabinoid and/or cannabimimetic
WO2023007440A1 (en)2021-07-302023-02-02Nicoventures Trading LimitedAerosol generating substrate comprising microcrystalline cellulose
JP2024537801A (en)2021-09-302024-10-16ニコベンチャーズ トレーディング リミテッド Oral gum composition
WO2023053062A1 (en)2021-09-302023-04-06Nicoventures Trading LimitedOral product with a basic amine and an ion pairing agent
EP4432862A1 (en)2021-11-152024-09-25Nicoventures Trading LimitedOral products with nicotine-polymer complex
JP2024546044A (en)2021-11-152024-12-17ニコベンチャーズ トレーディング リミテッド Products with enhanced sensory properties
EP4503974A1 (en)2022-04-062025-02-12Nicoventures Trading LimitedPouched products with heat sealable binder
WO2023232332A2 (en)2022-04-142023-12-07Nicoventures Trading LimitedContainer for oral products
US20250241356A1 (en)2022-06-242025-07-31Michael S. DanielOral composition comprising receptor modulator
US20240109697A1 (en)2022-10-032024-04-04Nicoventures Trading LimitedSealing member for packaging
WO2024074988A1 (en)2022-10-042024-04-11R. J. Reynolds Tobacco CompanyStackable arrangement of product containers and related method of stacking
EP4598367A1 (en)2022-10-072025-08-13Nicoventures Trading LimitedOral product
WO2024074839A1 (en)2022-10-072024-04-11Nicoventures Trading LimitedOral product
EP4598366A1 (en)2022-10-072025-08-13Nicoventures Trading LimitedOral product
WO2024079697A1 (en)2022-10-142024-04-18Nicoventures Trading LimitedApparatus and method for manufacturing a pouched product
EP4601490A1 (en)2022-10-142025-08-20Nicoventures Trading LimitedCapsule-containing pouched products
EP4601952A1 (en)2022-10-142025-08-20Nicoventures Trading LimitedApparatus and method for manufacturing and inspecting a pouched product or at least one object associated therewith
EP4608181A1 (en)2022-10-242025-09-03Nicoventures Trading LimitedShaped pouched products
WO2024095162A1 (en)2022-11-012024-05-10Nicoventures Trading LimitedMethod of preparing a pouched product comprising a nicotine salt
WO2024095163A1 (en)2022-11-012024-05-10Nicoventures Trading LimitedOral composition comprising encapsulated ph adjusting agent
EP4611565A1 (en)2022-11-012025-09-10Nicoventures Trading LimitedProducts with spherical filler
WO2024171117A1 (en)2023-02-152024-08-22Nicoventures Trading LimitedOral products with high-density load
WO2024180481A1 (en)2023-02-282024-09-06Nicoventures Trading LimitedCaffeine-containing oral product
WO2024188759A1 (en)*2023-03-102024-09-19Jt International SaMethod of production of a plurality of flat shaped aerosol generating substrates and associated tobacco article
WO2024201343A1 (en)2023-03-302024-10-03Nicoventures Trading LimitedOral compositions and methods of manufacture
WO2024201372A1 (en)2023-03-312024-10-03Nicoventures Trading LimitedMulti-compartment storage container for oral products
WO2024201301A1 (en)2023-03-312024-10-03Nicoventures Trading LimitedStarchless molding process for oral products
WO2024201346A1 (en)2023-03-312024-10-03Nicoventures Trading LimitedFunctionalized fleece material production
WO2025062340A1 (en)2023-09-222025-03-27R. J. Reynolds Tobacco CompanyNicotine extraction from plastic packaging materials
GB202319627D0 (en)2023-12-202024-01-31Nicoventures Trading LtdDiffusion-modifying pouch for oral products
GB202319624D0 (en)2023-12-202024-01-31Nicoventures Trading LtdFunctionalized fleece for oral products
GB202319617D0 (en)2023-12-202024-01-31Nicoventures Trading LtdElastic fleece for oral products
GB202319623D0 (en)2023-12-202024-01-31Nicoventures Trading LtdBiodegradable fleece for oral product
GB202319621D0 (en)2023-12-202024-01-31Nicoventures Trading LtdOral product comprising porous sponge
EP4585059A1 (en)2024-01-122025-07-16Nicoventures Trading LimitedEffervescent pouched product
EP4585055A1 (en)2024-01-122025-07-16Nicoventures Trading LimitedOral product with probiotic component
EP4595781A1 (en)2024-01-312025-08-06Nicoventures Trading LimitedPouched products containing shreddable filler
EP4599698A1 (en)2024-02-072025-08-13Nicoventures Trading LimitedProducts comprising sensory agents
EP4602929A1 (en)2024-02-192025-08-20Nicoventures Trading LimitedOral product with powder coating
EP4620318A1 (en)2024-03-212025-09-24Nicoventures Trading LimitedPouched product with humectant
EP4623708A1 (en)2024-03-262025-10-01Nicoventures Trading LimitedSweetener composition for pouched oral products
EP4623702A1 (en)2024-03-272025-10-01Nicoventures Trading LimitedOral product

Citations (6)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
CN1561214A (en)*2001-09-272005-01-05法马西亚公司New formulations and use thereof
CN1960648A (en)*2003-11-072007-05-09美国无烟烟草制品公司 tobacco composition
CN101272703A (en)*2005-09-222008-09-24R.J.雷诺兹烟草公司Smokeless tobacco composition
CN101355885A (en)*2005-11-072009-01-28恩杰特公司Nicotine with a reduced content of nitrosamines
CN101495002A (en)*2006-08-012009-07-29R.J.雷诺兹烟草公司Smokeless tobacco
CN101873809A (en)*2007-07-232010-10-27R.J.雷诺兹烟草公司Smokeless tobacco compositions and methods of treating tobacco for use therein

Family Cites Families (124)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US1376586A (en)1918-04-061921-05-03Schwartz FrancisTobacco-tablet
US3696917A (en)1970-09-101972-10-10Elaine G LeviTobacco pouch closure
GB1489761A (en)1974-03-081977-10-26Amf IncProcess of treating tobacco
GB1550835A (en)1975-08-181979-08-22British American Tobacco CoTreatment of tobacco
US4150677A (en)1977-01-241979-04-24Philip Morris IncorporatedTreatment of tobacco
US4267847A (en)1978-05-121981-05-19British-American Tobacco Company LimitedTobacco additives
US4289147A (en)1979-11-151981-09-15Leaf Proteins, Inc.Process for obtaining deproteinized tobacco freed of nicotine and green pigment, for use as a smoking product
US4589428A (en)1980-02-211986-05-20Philip Morris IncorporatedTobacco treatment
DE3009032C2 (en)1980-03-081983-11-24B.A.T. Cigaretten-Fabriken Gmbh, 2000 Hamburg Process for the production of flavorings for smoking products
DE3009031C2 (en)1980-03-081983-04-21B.A.T. Cigaretten-Fabriken Gmbh, 2000 Hamburg Process for the production of flavorings for smoking products
IN158943B (en)1981-12-071987-02-21Mueller Adam
US4528993A (en)1982-08-201985-07-16R. J. Reynolds Tobacco CompanyProcess for producing moist snuff
US4660577A (en)1982-08-201987-04-28R.J. Reynolds Tobacco CompanyDry pre-mix for moist snuff
US4513756A (en)1983-04-281985-04-30The Pinkerton Tobacco CompanyProcess of making tobacco pellets
JPS6024172A (en)1983-07-211985-02-06日本たばこ産業株式会社Production of tobacco flavor
US5092352A (en)1983-12-141992-03-03American Brands, Inc.Chewing tobacco product
US4624269A (en)1984-09-171986-11-25The Pinkerton Tobacco CompanyChewable tobacco based product
US4716911A (en)1986-04-081988-01-05Genencor, Inc.Method for protein removal from tobacco
US4727889A (en)1986-12-221988-03-01R. J. Reynolds Tobacco CompanyTobacco processing
US5018540A (en)1986-12-291991-05-28Philip Morris IncorporatedProcess for removal of basic materials
US5005593A (en)1988-01-271991-04-09R. J. Reynolds Tobacco CompanyProcess for providing tobacco extracts
US4936920A (en)*1988-03-091990-06-26Philip Morris IncorporatedHigh void volume/enhanced firmness tobacco rod and method of processing tobacco
US5435325A (en)1988-04-211995-07-25R. J. Reynolds Tobacco CompanyProcess for providing tobacco extracts using a solvent in a supercritical state
US4887618A (en)1988-05-191989-12-19R. J. Reynolds Tobacco CompanyTobacco processing
US4987907A (en)1988-06-291991-01-29Helme Tobacco CompanyChewing tobacco composition and process for producing same
US4967771A (en)1988-12-071990-11-06R. J. Reynolds Tobacco CompanyProcess for extracting tobacco
US4986286A (en)1989-05-021991-01-22R. J. Reynolds Tobacco CompanyTobacco treatment process
US4941484A (en)1989-05-301990-07-17R. J. Reynolds Tobacco CompanyTobacco processing
US5121757A (en)1989-12-181992-06-16R. J. Reynolds Tobacco CompanyTobacco treatment process
US5060669A (en)1989-12-181991-10-29R. J. Reynolds Tobacco CompanyTobacco treatment process
US4991599A (en)1989-12-201991-02-12Tibbetts Hubert MFiberless tobacco product for smoking and chewing
US5131414A (en)1990-02-231992-07-21R. J. Reynolds Tobacco CompanyTobacco processing
US5234008A (en)1990-02-231993-08-10R. J. Reynolds Tobacco CompanyTobacco processing
US5065775A (en)1990-02-231991-11-19R. J. Reynolds Tobacco CompanyTobacco processing
US5099682A (en)1990-03-121992-03-31Denomme Catherine EMeat doneness tester
US5099862A (en)1990-04-051992-03-31R. J. Reynolds Tobacco CompanyTobacco extraction process
US5074319A (en)1990-04-191991-12-24R. J. Reynolds Tobacco CompanyTobacco extraction process
US5668295A (en)1990-11-141997-09-16Philip Morris IncorporatedProtein involved in nicotine synthesis, DNA encoding, and use of sense and antisense DNAs corresponding thereto to affect nicotine content in transgenic tobacco cells and plants
WO1992014761A1 (en)1991-02-201992-09-03Pfizer Inc.Reduced polydextrose
US5131415A (en)1991-04-041992-07-21R. J. Reynolds Tobacco CompanyTobacco extraction process
US5318050A (en)1991-06-041994-06-07R. J. Reynolds Tobacco CompanyTobacco treatment process
US5197494A (en)1991-06-041993-03-30R.J. Reynolds Tobacco CompanyTobacco extraction process
US5343879A (en)1991-06-211994-09-06R. J. Reynolds Tobacco CompanyTobacco treatment process
US5360022A (en)1991-07-221994-11-01R. J. Reynolds Tobacco CompanyTobacco processing
US5148819A (en)1991-08-151992-09-22R. J. Reynolds Tobacco CompanyProcess for extracting tobacco
US5230354A (en)1991-09-031993-07-27R. J. Reynolds Tobacco CompanyTobacco processing
US5243999A (en)1991-09-031993-09-14R. J. Reynolds Tobacco CompanyTobacco processing
US5301694A (en)1991-11-121994-04-12Philip Morris IncorporatedProcess for isolating plant extract fractions
US5445169A (en)1992-08-171995-08-29R. J. Reynolds Tobacco CompanyProcess for providing a tobacco extract
US5387416A (en)1993-07-231995-02-07R. J. Reynolds Tobacco CompanyTobacco composition
US5539093A (en)1994-06-161996-07-23Fitzmaurice; Wayne P.DNA sequences encoding enzymes useful in carotenoid biosynthesis
US5637785A (en)1994-12-211997-06-10The Salk Institute For Biological StudiesGenetically modified plants having modulated flower development
US5705624A (en)1995-12-271998-01-06Fitzmaurice; Wayne PaulDNA sequences encoding enzymes useful in phytoene biosynthesis
US6906172B2 (en)1998-03-102005-06-14Large Scale Biology CorporationFlexible processing apparatus for isolating and purifying viruses, soluble proteins and peptides from plant sources
US6298859B1 (en)1998-07-082001-10-09Novozymes A/SUse of a phenol oxidizing enzyme in the treatment of tobacco
WO2000009725A2 (en)1998-08-112000-02-24Biosource Technologies, Inc.Method for recovering proteins from the interstitial fluid of plant tissues
US7229658B1 (en)*1998-10-282007-06-12San-Ei Gen F.F.I., IncCompositions containing sucralose and application thereof
US6131584A (en)1999-04-152000-10-17Brown & Williamson Tobacco CorporationTobacco treatment process
US6805134B2 (en)1999-04-262004-10-19R. J. Reynolds Tobacco CompanyTobacco processing
US6371126B1 (en)2000-03-032002-04-16Brown & Williamson Tobacco CorporationTobacco recovery system
US7192771B2 (en)2000-08-302007-03-20North Carolina State UniversityPlant promoter sequence
WO2002072775A2 (en)2001-03-082002-09-19Michigan State UniversityLipid metabolism regulators in plants
JP4017526B2 (en)2001-05-012007-12-05リージェント コート テクノロジーズ エルエルシー Smokeless tobacco products
US20040020503A1 (en)2001-05-012004-02-05Williams Jonnie R.Smokeless tobacco product
US6668839B2 (en)2001-05-012003-12-30Jonnie R. WilliamsSmokeless tobacco product
US7208659B2 (en)2001-05-022007-04-24Conopco Inc.Process for increasing the flavonoid content of a plant and plants obtainable thereby
US6730832B1 (en)2001-09-102004-05-04Luis Mayan DominguezHigh threonine producing lines of Nicotiana tobacum and methods for producing
US7032601B2 (en)2001-09-282006-04-25U.S. Smokeless Tobacco CompanyEncapsulated materials
US6953040B2 (en)2001-09-282005-10-11U.S. Smokeless Tobacco CompanyTobacco mint plant material product
US6817970B2 (en)2002-06-172004-11-16Large Scale Biology CorporationCentrifuge for extracting interstitial fluid
US6772767B2 (en)2002-09-092004-08-10Brown & Williamson Tobacco CorporationProcess for reducing nitrogen containing compounds and lignin in tobacco
DE10249840A1 (en)*2002-10-252004-05-13Robert Bosch Gmbh Fuel injection device for internal combustion engines
US7025066B2 (en)2002-10-312006-04-11Jerry Wayne LawsonMethod of reducing the sucrose ester concentration of a tobacco mixture
SE0301244D0 (en)2003-04-292003-04-29Swedish Match North Europe Ab Smokeless tobacco product user package
US7014039B2 (en)2003-06-192006-03-21R.J. Reynolds Tobacco CompanySliding shell package for smoking articles
SE527350C8 (en)2003-08-182006-03-21Gallaher Snus Ab Lid for snuff box
BRPI0415682A (en)2003-11-032006-12-19Us Smokeless Tobacco Co flavored smokeless tobacco and manufacturing methods
WO2005046363A2 (en)2003-11-072005-05-26U.S. Smokeless Tobacco CompanyTobacco compositions
US8627828B2 (en)*2003-11-072014-01-14U.S. Smokeless Tobacco Company LlcTobacco compositions
EP1729602A1 (en)2003-12-222006-12-13U.S. Smokeless Tobacco CompanyConditioning process for tobacco and/or snuff compositions
ATE438390T1 (en)2004-07-022009-08-15Radi Medical Biodegradable Ab SMOKELESS TOBACCO PRODUCT
JP4875616B2 (en)2004-07-062012-02-15ガムリンク エー／エス Compressed chewing gum tablets
US7337782B2 (en)2004-08-182008-03-04R.J. Reynolds Tobacco CompanyProcess to remove protein and other biomolecules from tobacco extract or slurry
EP1781123A1 (en)2004-08-232007-05-09U.S. Smokeless Tobacco CompanyNicotiana compositions
US7650891B1 (en)2004-09-032010-01-26Rosswil Llc Ltd.Tobacco precursor product
FR2875409B1 (en)2004-09-172010-05-07Sanofi Aventis PHARMACEUTICAL COMPOSITION COMPRISING A SOLID POLYMERIC MATRIX DISPERSION COMPRISING A CONTINUOUS PHASE OF POLYDEXTROSE AND A CONTINUOUS PHASE OF A POLYMER OTHER THAN POLYDEXTROSE
WO2007012980A1 (en)2005-06-012007-02-01Philip Morris Products S.A.Tobacco with an increased level of natural tar dilutents
US7537110B2 (en)2005-06-022009-05-26Philip Morris Usa Inc.Container for consumer article
US7584843B2 (en)2005-07-182009-09-08Philip Morris Usa Inc.Pocket-size hand-held container for consumer items
US7861728B2 (en)2006-02-102011-01-04R.J. Reynolds Tobacco CompanySmokeless tobacco composition having an outer and inner pouch
CN101316517A (en)*2005-09-302008-12-03Wm.雷格利Jr.公司Oral composition and method for stress reduction associated with smoking cessation
US7819124B2 (en)2006-01-312010-10-26U.S. Smokeless Tobacco CompanyTobacco articles and methods
US7810507B2 (en)2006-02-102010-10-12R. J. Reynolds Tobacco CompanySmokeless tobacco composition
SE529886C2 (en)2006-04-282007-12-18Swedish Match North Europe Ab A new method for preparing a moisturizing snuff composition that does not contain tobacco
US20080173317A1 (en)2006-08-012008-07-24John Howard RobinsonSmokeless tobacco
US20080029117A1 (en)2006-08-012008-02-07John-Paul MuaSmokeless Tobacco
WO2008016520A2 (en)*2006-08-012008-02-07R.J. Reynolds Tobacco CompanySmokeless tobacco
US8017168B2 (en)*2006-11-022011-09-13The Coca-Cola CompanyHigh-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
WO2008073360A2 (en)2006-12-122008-06-19Meadwestvaco CorporationPackage with pivoting cover
BRPI0807783A2 (en)2007-02-232014-06-24Us Smokeless Tobacco Co SMOKE-FREE TOBACCO COMPOSITION, METHODS FOR PRODUCING PLANT VARIETY AND FOR PREPARING TOBACCO WITH REDUCED AMARGOR, TOBACCO PLANT, AND CURED TOBACCO.
US8186360B2 (en)2007-04-042012-05-29R.J. Reynolds Tobacco CompanyCigarette comprising dark air-cured tobacco
US8393465B2 (en)2007-05-072013-03-12Philip Morris Usa Inc.Pocket-size hybrid container for consumer items
CN101677945A (en)*2007-05-082010-03-24赫尔克里士公司Robust rapid disintegration tablet formulation
WO2009004488A2 (en)2007-06-082009-01-08Philip Morris Products S.A.Capsule clusters for oral consumption
US7946295B2 (en)2007-07-232011-05-24R. J. Reynolds Tobacco CompanySmokeless tobacco composition
US8061362B2 (en)2007-07-232011-11-22R. J. Reynolds Tobacco CompanySmokeless tobacco composition
USD594154S1 (en)2007-11-132009-06-09R.J. Reynolds Tobacco CompanyContainer with bottom compartment
US8336557B2 (en)2007-11-282012-12-25Philip Morris Usa Inc.Smokeless compressed tobacco product for oral consumption
US7878324B2 (en)2007-11-302011-02-01Philip Morris Usa Inc.Pocket-size container for consumer items
SE0800058L (en)*2008-01-102009-07-11British American Tobacco Co Tobacco product for oral use
US20090230003A1 (en)2008-02-082009-09-17Philip Morris Usa Inc.Pocket-sized container
USD592956S1 (en)2008-02-082009-05-26Philip Morris Usa Inc.Container
US8033425B2 (en)2008-03-042011-10-11R.J. Reynolds Tobacco CompanyDispensing container
US7946450B2 (en)2008-04-252011-05-24R.J. Reynolds Tobacco CompanyDispensing container
US9248935B2 (en)2008-12-012016-02-02R.J. Reynolds Tobacco CompanyDual cavity sliding dispenser
US9155772B2 (en)2008-12-082015-10-13Philip Morris Usa Inc.Soft, chewable and orally dissolvable and/or disintegrable products
US8377215B2 (en)2008-12-182013-02-19Philip Morris Usa Inc.Moist botanical pouch processing
US9167835B2 (en)2008-12-302015-10-27Philip Morris Usa Inc.Dissolvable films impregnated with encapsulated tobacco, tea, coffee, botanicals, and flavors for oral products
EP2213181A1 (en)2009-01-282010-08-04Philip Morris Products S.A.Smokeless dissolvable compressed tobacco product
BRPI1010548A2 (en)2009-05-112016-03-15Us Smokeless Tobacco Co encapsulated flavoring composite, encapsulated artificial sweetener composite and product.
US20110139164A1 (en)2009-12-152011-06-16R. J. Reynolds Tobacco CompanyTobacco Product And Method For Manufacture
US8955523B2 (en)2010-01-152015-02-17R.J. Reynolds Tobacco CompanyTobacco-derived components and materials
US9039839B2 (en)2010-04-082015-05-26R.J. Reynolds Tobacco CompanySmokeless tobacco composition comprising tobacco-derived material and non-tobacco plant material
US9402415B2 (en)2010-04-212016-08-02R. J. Reynolds Tobacco CompanyTobacco seed-derived components and materials

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
CN1561214A (en)*2001-09-272005-01-05法马西亚公司New formulations and use thereof
CN1960648A (en)*2003-11-072007-05-09美国无烟烟草制品公司 tobacco composition
CN101272703A (en)*2005-09-222008-09-24R.J.雷诺兹烟草公司Smokeless tobacco composition
CN101355885A (en)*2005-11-072009-01-28恩杰特公司Nicotine with a reduced content of nitrosamines
CN101495002A (en)*2006-08-012009-07-29R.J.雷诺兹烟草公司Smokeless tobacco
CN101873809A (en)*2007-07-232010-10-27R.J.雷诺兹烟草公司Smokeless tobacco compositions and methods of treating tobacco for use therein

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