CN103316039A - Pharmaceutical composition for treating renal failure in pets - Google Patents

Abstract

The present invention relates to a pharmaceutical composition for treating renal failure caused by various diseases or pets who cannot be recovered from conventional or renal replacement renal failure medical treatment. The medicine composition comprises a liquid A and a liquid B, the relative proportion of the liquid A to the liquid B is 1: 1, and the liquid A and the liquid B respectively contain the following components and contents: solution A: 7-42.5g/L of glucose, 70-132mEq/L of sodium ions, 45-96mEq/L of chloride ions, 1.5-3.5mEq/L of calcium ions, 0.2-0.5mEq/L of magnesium ions and 20-40mEq/L of lactate ions; and B, liquid B: 60-130mEq/L of sodium ions, 50-109mEq/L of chloride ions, 15-28mEq/L of lactate ions, 2.2-4mEq/L of potassium ions and 1.5-3.0mEq/L of calcium ions. The medicinal composition provided by the invention is administrated to pets by a subcutaneous injection mode for treatment, and has the advantages of simple use, no need of operation, hospitalization and/or infusion, quick health recovery, reduction of medical cost, great increase of recovery rate, reduction of fatality rate and the like. The pharmaceutical composition provided by the invention can also be applied to continuous care treatment of renal failure of pets.

Description

The medical composition that is used for the treatment of house pet renal failure

Technical field

The present invention is the relevant medical composition that is used for the treatment of the house pet renal failure that causes because of various diseases.

Background technology

No matter renal failure is the people or animal is all one of common disease.When having renal failure to occur, i.e. expression has the kidney unit more than 75% to lose normal physiological function, and then causes the accumulation of metabolic waste, and the imbalance of liquid, electrolyte and soda acid seriously can cause the general complication and causes death.Although the kidney injury that acute renal failure causes is reversible, but, according to the Master's thesis (Lin Kaiwei of Chung Hsing University, " affect the prognostic indicator of toy acute renal failure and the assessment that dog is only used the central vein catheter-related Infections: Clinical Study ", the institute master of veterinary of Chung Hsing University research paper, 2007), acute renal failure (acute renal failure, ARF) under different therapeutic modalities (for example traditional infusion therapy, peritoneal dialysis and Hemodialysis) still has the fatality rate of 30-83%.(Behrend EN，Grauer GF，Mani I，Groman RP，Salman MD，Greco DS，“Hospital-acquired acute renal failure in dogs：29 cases”(1983-1992)，J Am Vet Med Assoc 208：537-541，1996；Crisp MS，Chew DJ，DiBartola SP，Birchard SJ，“Peritoneal dialysis in dogs and cats：27cases”(1976-1987)，J Am Vet Med Assoc 195：1262-1266，1989；Forrester SD，McMillan NS，Ward DL，“Retrospective evaluation of acute renal failure in dogs”，J Vet Intern Med 16：354，2002.)。In addition, also mention in the paper of Lin Kaiwei between in January, 2000 to 2006 year December, have 1,339 dog case and 241 cat cases are gone to a doctor in veterinary teaching hospital of Chung Hsing University because of renal failure.Year prevalence rate and the fatality rate of renal failure only are respectively 4-10% and 49-59% dog, then are 2-10% and 33-62% only cat.Be judged to be the animal of acute renal failure (501 for dog only, 69 for cat only) in, the whole year fatality rate of dog cat is respectively 81.2% and 65.2%.

Still high to the fatality rate of toy in view of ARF, the existing scholar's research prognostic factor relevant with ARF is to can be used as the early prognosis index and selecting suitable therapeutic modality.Whether the prognosis of ARF must be on causing the cause of disease, kidney extent of injury and follows Other diseases to decide, but about in this respect documents and materials still limited and result be not quite similar.

The therapeutic modality of toy renal failure comprises traditional remedies, kidney substituted therapy and dietetic therapy at present.Below further specify with regard to traditional remedies and kidney substituted therapy.

One, traditional treatment

The traditional treatment mode of renal failure for toy, mainly supporting with infusion treatment as main (namely using the intravascular injection drop), in order to correcting body fluid, electrolyte and acid base imbalance, and reduces kidney and further injures; Reach and use western medicine.This method is take the depletion for the treatment of reversibility kidney as main (the expression kidney is momentary injury or because the caused renal index of other factors temporarily raises, after treatment can recuperator).If irreversible kidney depletion generally all can be more and more serious, then cause the nephropathy change seriously even cause death of pet.If (for example BUN (blood urea nitrogen) and CRE (kreatinin)) is more and more serious for renal index, the veterinarian will announce to want house pet euthanasia or carry out peritoneum and hemodialysis, and house pet is through peritoneal dialysis and hemodialysis can't be got well or even last dead sometimes.

Two, kidney substituted treatment (Renal replacement therapy)

The temporary transient renal function that replaces of kidney substituted treatment general reference to allow kidney recover the therapeutic modality of normal function, comprises peritoneal dialysis, hemodialysis, even kidney moves and the method such as grows.ARF is one of indication of dog cat dialysis (peritoneum or blood) treatment.Traditionally, usually take three to around supporting treatment (namely using the intravascular injection drop) reaction result as the difference renal failure whether as recoverable criterion, if the house pet that can't recover under support and infusion treatment just must carry out dialysis treatment, but under the intervention of dialysis, then the survival of house pet renal failure may be able to extend to the several months.When animal has serious few urine or anuria, and traditional treatment (supporting and infusion treatment) be can't effectively improve azotemia and body fluid, electrolyte and acid base imbalance the time, (peritoneum or the hemodialysis) treatment of namely must dialysing immediately.(Cowgill LD，Elliott DA.Hemodialysis.In：DiBartola SP，ed.“Fluid Therapy in Small Animal Practice”，2th ed.W.B.Saunder Co.，Philadelphia，USA，1615-1633，2000；Whittemore JC，Webb CB.“Beyond Fluid Therapy：Treating Acute Renal Failure”，CompCont Ed Pract Vet，27：288-297，2005)。Hemodialysis is a technical feasible therapeutic modality, can be in order to treat serious uremia.But because the availability for the treatment of and economic considering (price is too expensive, and 7 days approximately 160,000, and the continued treatment effect is indefinite) so that the application of hemodialysis is not general.Below only further specify with regard to peritoneal dialysis and hemodialysis.

A. peritoneal dialysis (Peritoneal dialysis, PD)

Principle and method:

Its method will be for containing approximation in the normally dialysis solution of electrolyte and glucose, implant a nonvolatil Dialysis tubing at abdominal part, and directly dialysis solution is poured into intraperitoneal, cross principle by diffusion, convection current (convection) with microfiltration, allow peritoneum as penetrating film blood plasma small molecular material (such as the uremic refuse) and ion and dialysis solution be exchanged, to reach the balance of correcting cylinder electrolyte and body fluid.

Taboo and inadaptation:

Because peritoneal dialysis mainly relies on peritoneum as the penetrating film of mass exchange, so under any situation of hindering the dialysis solution exchange, the neither peritoneal dialysis treatment that carries out similarly is that trauma of abdomi napwall or peritoneal infection are so that peritoneumexchange area forfeiture 50% above person.In addition, animal itself has serious hypoalbuminemia or can disturb the situations such as peritoneal dialysis catheters placement, such as serious ascites, implemented the taboo that abdominal operation, abdominal cavity agglomerate or enterectasis etc. are all peritoneal dialysis in the recent period.Also has the peritoneal membrane function meeting because become fibrosis after the permanent dialysis.This is the more and more bad problem of peritoneal dialysis meeting.

Problem and complication:

Although the technology of peritoneal dialysis is simple, its probability that causes complication is high, thereby limits its general use.The common complication of peritoneal dialysis is low white egg mass formed by blood stasis, other problem comprises that dialysis solution is detained or dialysis catheter obstruction, peritonitis etc., whole survival rate is 22% (Crisp MS, Chew DJ, DiBartola SP, Birchard SJ " Peritoneal Dialysis in Dogs and Cats:27 Cases " (1976-1987), J Am Vet Med Assoc.195:1262-1266,1989).In addition, the people such as Beckel (Beckel NF, Toole TE, Rozanski EA, Labato MA. " Peritoneal Dialysis in the Managementof Acute Renal Failure in 5 Dogs with Leptospirosis ", J Vet Emerg Crit Care, 15:201-205,2005) report carries out peritoneal dialysis to 6 dogs of leptospiral infection, and the result shows that complication includes hypokalemia (60%).

B. hemodialysis (Hemodialysis, HD)

Principle and method:

The hemodialysis principle is similar to peritoneal dialysis, but with Dialysis tubing (hemodialyzer) as the solute clearing house.Its method is for directly exchanging blood with extracorporeal with dialysis solution, but when carrying out hemodialysis, reaches balance in order to prevent the solute exchange, can be with blood and dialysis solution continuous updating, and to keep Concentraton gradient and to reach the diffusion of maximum.

Hemodialysis opportunity and indication:

Hemodialysis is that ARF and its complication, acute poisoning and body fluid are excessive etc. for the topmost indication of dog cat.In addition, hemodialysis can be used for kidney and moves and grow the acute rejection that postoperative produces, and keeps ill domestic animal until situation is removed.

Complication:

Hemodialysis is the therapeutic process of a technical complexity, can be applicable to the sufferer of physiology and metabolic confusion.

General common complication comprises: dialysis catheter insufficiency of function or infection, hypotension, neurological complication, respiratory system complication, leukocyte and thrombocytopenia and anemia and aminoacid loss etc.But the complication of hemodialysis can affect multiple kidney external system because of the complexity of dialysis procedure itself and the complication of renal failure, therefore this adverse effect that is not easily distinguishable is the result that dialysis treatment itself or uremic cause, but these untoward reaction meetings are along with adaptation or the uremic of animal to dialysis obtains to control and reducing work frequency and intensity.(Cowgill LD，Langston CE.“Role of Hemodialysis in the Management of Dogs and Cats with Renal Failure”，Vet Clin North Am Small Anim Pract，26：1347-1378，1996)。

Can be understood by above-mentioned explanation, the fatality rate of the house pet renal failure Therapeutic Method that uses at present is still very high, and the therapeutic effect of peritoneal dialysis and/or hemodialysis and cost still remain to be improved, and therefore still needs new Therapeutic Method.

Summary of the invention

For improving the shortcoming of the treatment house pet renal failure method of using at present as mentioned above, one of purpose of the present invention provides a kind of novel pharmaceutical compositions that is used for the treatment of house pet renal failure.

The present invention also aims to provide a kind of mode by the subcutaneous injection administration to be used for the treatment of the novel pharmaceutical compositions of house pet renal failure.

For achieving the above object, the invention provides a kind of medical composition that is used for the treatment of house pet renal failure by hypodermic mode, it comprises A liquid and B liquid, and wherein A liquid and B liquid comprise respectively following component:

A liquid

B liquid

Preferably, the medical composition that is used for the treatment of house pet renal failure by the subcutaneous injection administering mode provided by the invention comprises A liquid and the B liquid that contains following component:

A liquid

B liquid

Above-mentioned A liquid is known in prior art, but mainly is that the mode of utilizing the peritoneum in abdominal cavity to exchange to reduce toxin is treated renal failure, but when being applied to the peritoneal dialysis of dog cat, poor effect, and easily infect peritonitis.The inventor finds to use A liquid, utilizes the administration of subcutaneous injection mode, owing to utilizing subcutaneous tissue but not peritoneum exchanges the toxin of renal failure, exchange rate improves, thereby improves the house pet recovery rate.

Above-mentioned B liquid also is known in prior art, but mainly only is to utilize the intravascular injection mode to be applied to the mankind or animal, is used for replenishing the fluid loss of burn, diarrhoea, and while liquid make-up electrolyte, slightly corrects acidosis.Although, existing prior art discloses above-mentioned B liquid and can be applicable to the treatment of (animal) renal failure, but poor effect, and must use high-dose therapy (for example, every day the 40-60mL/ kg body weight, take 20 kg body weight dogs only as example, need injection 800-1200mL liquid, and take 5 kilograms cat as example, just must every day each about 100-200mL liquid sooner or later), easily cause the house pet health seriously to bear.

In many ways test through the inventor and to find after adding clinical treatment, the combination of A liquid and B liquid (following sometimes referred to as " A+B liquid ") produces surprising synergism in treatment animal renal failure.In more detail, before the present invention, the medical composition that does not have existing skill to disclose or advise using the A of containing liquid provided by the invention and B liquid to make up passes through the administration of subcutaneous injection mode and at the surprising synergism for the treatment of animal renal failure generation, promotes uremic (BUN and CRE) to be discharged by health.

Herein, " combination of A liquid and B liquid " or " A+B liquid " term does not limit occupation mode and the order of A liquid and B liquid.In other words, " combination of A liquid and B liquid " or " A+B liquid " comprise first A liquid through subcutaneous injection in animal, then with B liquid through subcutaneous injection in animal; Perhaps first with B liquid through subcutaneous injection in animal, then with A liquid through subcutaneous injection in animal; Perhaps can with A liquid and B liquid directly mixes and through subcutaneous injection in animal.

In a specific embodiments of the present invention, the relative scale of A liquid and B liquid is preferably 1: 1, but the veterinarian still can adjust relative scale according to its experience and judgement according to the pet health situation clinically, and still within the scope of the invention.

In addition, the inventor also finds, compared to prior art, A+B liquid of the present invention can excrete toxin under extremely low dosage rapidly via urine, reach the effect for the treatment of, is difficult for causing the house pet health seriously to bear.According to the present invention, the general recommendations consumption is respectively the A liquid of 0.1-10mL/ kg body weight every day and the B liquid of 0.1-10mL/ kg body weight, every day each 1 to 3 time.But actual therapeutic dosage still need be looked pet health situation and the weight of animals and adjust according to veterinarian's experience and judgement.

According to a specific embodiments of the present invention, general first by beginning than the low dosage scope, then according to veterinarian's experience and judgement and look the pet health situation and slowly increase dosage.For example, initial A and the B liquid of distinguishing first example such as 0.1-5mL/ kg body weight, every day 1 to 3 time, approximately 1 to 3 day.After house pet adaptation medicine, beginning slowly increases dosage (5-10mL/ kg body weight for example, every day 1 to 3 time) injection a period of time is until pet health returns to 50-90% above (because indivedual ages of animal and health status have different recovery rates).If must continue to look after treatment, then can reduce dosage to the 0.1-5mL/ kg body weight according to health states, every day 1 to 3 time.For some large-scale dog situation only, be used for continuing looking after treatment A+B liquid amount in addition can be reduced to 75mL/32 kg body weight every day (approximately 2.3mL/ kg body weight).

In addition, the injected dose of medical composition provided by the invention also needs to decide according to the weight of animals, and overweight animal (more than 5 kilograms) calculation of dose is different from above-mentioned recommended doses.According to the present invention, the animal injected dose is preferably the approximately 50-70% of the former injection dosage of above-mentioned animal more than 5 kilograms.For example, the former injection dosage of 20kg animal is 20kg * 10mL/kg=200mL, then better injected dose is 200mL * 50%=100mL or 200mL * 70%=140mL, therefore the animal of 20kg in 1-10 days for the treatment of as long as A liquid and the B liquid about 100-140mL of each administration respectively, treat animal rebuild one's physical constitution healthy after the situation of just can looking further reduce injected dose.Therefore, the injected dose of medical composition provided by the invention is far below the conventional amount 40-60mL/ kg body weight of the B liquid of mentioning in the preamble.For example, for the house pet of 20 kg body weight, according to prior art, the conventional amount of B liquid is 800-1200mL, causes the serious load of health and subcutaneous injury.

Medical composition provided by the invention is to be administered to house pet to improve or treatment renal failure by the subcutaneous injection mode, is different from traditional infusion therapy, peritoneal dialysis and hemodialysis, so treatment approach and mechanism are not identical.

According to the present invention, renal failure means to comprise according to the renal failure that the known criterion of persons skilled in the art defines, for example, acute renal failure and chronic renal failure, or pre-renal failure exhaust with kidney renal failure (referring to: for example, Liu Jiayuan, " research of dog cat renal failure short-term prognosis correlation factor ", clinical group of Master's thesis of veterinary of Taiwan Univ. institute, 2005; The people such as Cai Han scholar, " hemodialysis is in the assessment of a dog renal failure treatment ", Taiwan veterinary's will, 29:353-358,2003; Lin Kaiwei, " affecting the prognostic indicator of toy acute renal failure and the assessment that dog is only used the central vein catheter-related Infections: Clinical Study ", the institute master of veterinary of Chung Hsing University research paper, 2007).In a specific embodiments, can be preferably by the renal failure that medical composition provided by the invention is treated acute renal failure and chronic renal failure.

In another specific embodiments, medical composition provided by the invention for the topmost indication of dog cat be acute renal failure the treatments such as emergency treatment, acute poisoning, and chronic renal failure sustain life continue to look after treatment.

According to the present invention, first aid one word refers to after house pet generation renal failure, through the veterinarian implement any form of therapy or without any treatment to being declared invalid, and need do peritoneum or hemodialysis, even after announcing euthanasia, the emergency treatment behavior of carrying out.The first aid purpose comprises keeps house pet life, and anti-straight renal failure further worsens, and promote to restore etc.

The criterion of house pet renal failure generally is that electrolyte (for example sodium, potassium, chlorine) checks as main in blood gas, blood biochemistry checking and the blood.Usually, acute renal failure and chronic renal failure are judged with BUN (blood urea nitrogen) value and CRE (kreatinin) value.For dog and the cat of health, normal BUN value is respectively 6-33mg/dL and 12-41mg/dL; Normal CRE value is respectively 0.6-1.6 and 0.7-2.5mg/dL.Define according to the kreatinin concentration graded with reference to the renal failure of the dog cat of international kidney internal medicine meeting (IRIS) according to the inventor, when the CRE value is higher than more than the 5mg/dL, assert that namely this house pet suffers from latter stage or acute renal failure.According to the present invention, therapeutic index or renal failure index mean BUN (blood urea nitrogen) value and CRE (kreatinin) value.Therefore according to another specific embodiments of the present invention, improve and/or treatment renal failure meaning after with medical composition treatment provided by the invention, therapeutic index or renal failure index are reduced to approaching or in range of normal value.

In addition, in some situation, the BUN of renal failure house pet and/or CRE value rise rapidly, but but variation of health.Therefore, also utilize the mode of observing house pet outward appearance and energy and the renal failure state of assessing house pet.The common interpretation symptom of acute renal failure comprises that asthenia, lethargy, spirit depressing, weakness, appetite are useless absolutely, dehydration, vomiting and dysentery, and more rare symptom comprises epilepsy, faintness and ataxia etc.Therefore according to another specific embodiments of the present invention, improve and/or treat renal failure meaning after treating with medical composition provided by the invention, above-mentioned these symptoms are slowed down and/or are eliminated.

In a specific embodiments, when the renal failure house pet after medical composition of the present invention treatment, the renal failure index can decline to a great extent, and preferably is reduced in the range of normal value.In detail, BUN and/or CRE value can decline to a great extent, and preferably are reduced to approach or in range of normal value.In another specific embodiments, the renal failure index can decline to a great extent in 1-10 days, preferably was reduced to approach or in range of normal value.In another specific embodiments, the fatality rate of dog cat house pet renal failure can reduce effectively, and for example young dog and cat are reduced to approximately 15-25%.In another specific embodiments, the renal failure house pet by originally torpescence, vomit, have dizzy spells and twitches, can in 1-10 days, become vivaciously, the power of not vomitting, reactivate, and not have other uncomfortable especially variation, being returned to normally slowly.In another specific embodiments, the medical composition for the treatment of house pet renal failure provided by the invention can provide more than the 50-90%, is preferably the above recovery rate of 60-90%, and the younger recovery of animal is better.Be respectively 81.2% and 65.2% (being that survival rate is respectively 18.8% and 34.8%) compared to the whole year fatality rate of the dog cat of tradition (drop method or peritoneum or hemodialysis) therapy, medical composition provided by the invention is the improved treatment effect significantly.

Usually house pet has arrived renal failure latter stage (this moment, therapeutic index can't descend always), and the veterinarian will advise carrying out the treatment of peritoneal dialysis or hemodialysis etc. or giving euthanasia.Must bestow the case of emergency medical service rescue for irreversible severe renal failure, when adopting peritoneal dialysis to do urgent rescue, in some serious cases, may need the high peritoneal dialysis treatment that arrives 8-12 time every day, and the house pet condition is at death's door worse and worse.The normal pet peritoneal dialysis one day was 2-5 time.If it is invalid that too many expression of peritoneal dialysis is treated the exchange rate of peritoneum of house pet of renal failure, do not reply leeway, even thereby suggestion carry out euthanasia.In another specific embodiments, after utilizing medical composition provided by the invention that the renal failure house pet is carried out urgent rescue, cure case (first aid recovery rate in 1-10 days), young dog cat house pet (0-6 year) is more than the 60-90%, old dog cat house pet (more than 7 years old) is about 50-60%, therefore the whole recovery rate of dog cat is more than the 50-90%.

In addition, according to another specific embodiments of the present invention, medical composition provided by the invention can further significantly improve house pet renal failure and continue to look after the treatment recovery rate.Usually, reversible renal failure only, otherwise remove peritoneum or hemodialysis stable after, the continuing of animal looked after treatment does not have specific process at present.In case be irreversible renal failure animal after diagnosing, when stablizing behind peritoneal dialysis or hemodialysis, if after removing peritoneal dialysis catheter or hemodialysis tube, the renal failure index still can rise, and at this moment continues to look after treatment and is only serious problems.So in another specific embodiments, medical composition provided by the invention also can be used for continuing to look after treatment except can being used for the treatment of house pet renal failure.Worsen death factors as long as no other, recover good renal failure house pet after the treatment, also can continue to utilize medical composition provided by the invention to continue to look after treatment.Therefore, what medical composition provided by the invention also can be applicable to house pet renal failure continues to look after treatment, thereby better therapeutic outcome is provided.

Therefore, provided by the inventionly can represent following advantages through the subcutaneous injection mode with the medical composition for the treatment of house pet renal failure:

(1) medical composition for the treatment of renal failure provided by the invention, its treatment approach and mechanism are different from the Therapeutic Method of present use, it has the effect that promotion toxin (BUN and CRE) is discharged, and the pet body endotoxin is descended more rapidly, allows house pet recover rapidly and keeps health.

(2) after general latter stage, the renal failure house pet passed through traditional treatment and peritoneum or hemodialysis, if therapeutic index rises always, continue to sustain life very difficult, this moment, the doctor can require peaceful therapy (or euthanasia) usually.Medical composition provided by the invention is failed to respond to any medical treatment or house pet that must peaceful therapy also provides a kind of effective treatment through judgement for these, is effectively continued house pet life.

(3) medical composition for the treatment of renal failure provided by the invention also can be used for treating the house pet that institute is judged to be acute renal failure or chronic renal failure.

(4) recovery rate of medical composition lifting renal failure provided by the invention reaches 60-90% above (recovery rate of geriatric animals is about 50-60% more than 7 years old), and can proceed to continue to look after treatment.

(5) medical composition provided by the invention, the method simple and convenient of its treatment renal failure, continuing after leaving hospital looked after treatment and can be carried out voluntarily by main being in of poultry, further promotes so that house pet recovers efficient.

(6) medical composition provided by the invention need not performed the operation, be in hospital or be had an intravenous drip, as long as subcutaneous injection namely can be treated renal failure.Allow animal reduce and infect, can untrammeledly take action.Treat house pet renal failure with the most human mode, and allow house pet lives dignity and extending life arranged.

(7) medical composition provided by the invention, the dosage (40-60mL/ kg body weight) that its subcutaneous injection therapeutic dose (0.1-10mL/ kg body weight) uses far below present method.

(8) side effect of medical composition provided by the invention is very low.Owing to not using transfusion or dialysis, thus the infection that causes such as conduit etc. can be exempted, thereby complication and to infect situation very low, safety improves many relatively.

According to the present invention, " recovery rate " refers to without any treatment or health status is not improved after other veterinarian requires to do drop treatment or blood or peritoneal dialysis treatment renal failure house pet, house pet is returned to original health status and reaches more than the 50-90% in 1-10 days after through medical composition provided by the invention treatment, and/or the BUN of house pet and/or CRE value significantly are reduced to and approach or in range of normal value, and/or house pet reactivate power, become vivaciously, do not vomit and do not have other uncomfortable especially variation, the quantity ratio.

According to the present invention, house pet one word comprises the animals such as dog, cat, rabbit, Mus, preferably dog or cat again.

Below, will further describe in the mode of embodiment representative specific embodiments of the present invention, but the purpose of these embodiment only is for explanation, certainly have no intention to limit content of the present invention and scope.Persons skilled in the art will understand that the parameters in the content of this description can modify and/or change and obtain result identical with flesh and blood of the present invention or that be equal to.

Description of drawings

That Fig. 1 a and Fig. 1 b show is the result of embodiment 1 and table 2.

That Fig. 2 a and Fig. 2 b show is the result of embodiment 2 and table 3.

That Fig. 3 a and Fig. 3 b show is the result of embodiment 3 and table 4.

That Fig. 4 a and Fig. 4 b show is the result of embodiment 4 and table 5.

That Fig. 5 a and Fig. 5 b show is the result ofembodiment 5 and table 6.

That Fig. 6 a and Fig. 6 b show is the result ofembodiment 6 and table 7.

That Fig. 7 a and Fig. 7 b show is the result ofembodiment 7 and table 8.

That Fig. 8 a and Fig. 8 b show is the result ofembodiment 8 and table 9.

That Fig. 9 a and Fig. 9 b show is the result of embodiment 9 and table 10.

That Figure 10 a and Figure 10 b show is the result ofembodiment 10 and table 11.

That Figure 11 a and Figure 11 b show is the result of embodiment 11 and table 12.

The specific embodiment

The preparation of compositions:

Allotment contains A liquid and the B liquid of following component and content respectively:

A liquid: 15g/L glucose, 132mEq/L sodium ion, 96mEq/L chloride ion, 3.5mEq/L calcium ion, 0.5mEq/L magnesium ion, and 40mEq/L lactate ion.

B liquid: 130mEq/L sodium ion, 109mEq/L chloride ion, 28mEq/L lactate ion, 4mEq/L potassium ion, and 3.0mEq/L calcium ion.

Detect and assessment:

The effect for the treatment of renal failure provided by the invention is assessed by the outward appearance that detects BUN (blood urea nitrogen) and CRE (kreatinin) value and observation house pet and energy.BUN and CRE value are to utilize to educate the biochemistry analyzer (SPOKEN 4430 types) that living limited company peddles and detected.Dog and cat under different health status BUN and the CRE value respectively tabular be described as follows shown in the table 1:

Table 1

In addition, also utilize the mode of observing house pet outward appearance and energy and the health status of assessing house pet.By observe house pet comprise that asthenia, spirit depressing, weakness, appetite are useless absolutely, the slowing down and/or eliminate and judge the effect for the treatment of renal failure of the symptoms such as dehydration, vomiting and dysentery.

Therapeutic Method:

Before administration, measure the health status that each is treated house pet, comprise and measure BUN and CRE value, and blood gas numerical value, the while is also observed house pet outward appearance and energy.Begin to carry out the medicine break-in, first with A liquid (0.1-5mL/ kg body weight) through subcutaneous injection in subcutaneous one side, the back of house pet, then that B liquid (0.1-5mL/ kg body weight) is subcutaneous in the back of house pet another side through subcutaneous injection.In some cases, if the health status of house pet allows, also A liquid and B liquid directly can be mixed and subcutaneous injection.After 8-12 hour, the A liquid of repetition subcutaneous injection same amount and B liquid are respectively once.Continue subcutaneous injection 2-3 time every day, and periodic measurement BUN and CRE value and observation house pet outward appearance and energy, experience approximately 1 to 3 day.When house pet has been accepted the break-in medicine, then adjusted gradually respectively measuring to 5-10mL/ kg body weight (every day 1 to 3 time) (just can be reduced to the dosage below the 10mL/ kg body weight if the toxin expelling treatment (gold first aid phase, namely the 1st to 10 day) and getting well of house pet by medicine running-in period reaches more than the 50-90% (because indivedual ages of animal and health status have different recovery rates)) of A liquid and B liquid at 4-10 days.If animal recovers good in 7-10 days, spirit and expression in the eyes energy are pretty good, then can be directly the mixed liquor of A liquid and B liquid be carried out subcutaneous injection this moment.And can prolong according to circumstances natural law or reduce dosage.

Embodiment 1 (dog) house pet name: kiki

Master data: house pet kind: Maltese; Sex: mother; Age: 14 years old; 4 kilograms of body weight.

The health status of (the 0th day) animal before the administration: inappropriate medication causes acute renal failure, healthy very fast deterioration.

Medicine and mode: each plays subcutaneous injection administration on one side first for A liquid and B liquid, and then (the 3rd day) beaten fewer and fewer directly with the administration of A+B mixed liquor.

The therapeutic outcome that throwing takes behind the medical composition provided by the invention is shown in following table 2 and Fig. 1 a and Fig. 1 b:

Table 2

Natural law	The 0th day	The 6th day	The 184th day
				Cosmetic variation	The unable vomiting of lethargy	Normal strong	Normal strong
BUN(mg/dL)	92	117	17
				CRE(mg/dL)	7.9	8.4	1.1

[0095]Embodiment 2 (dog) house pet name: skin skin

Master data: house pet kind: miscegenation dog; Sex: mother; Age: 6 years old; 18 kilograms of body weight.

The health status of (the 0th day) animal before the administration: use steroid therapy to cause acute renal failure, the healthy deterioration.

Medicine and mode: directly with the administration of A+B mixed liquor.

Throwing takes therapeutic outcome behind the medical composition provided by the invention in following table 3 and Fig. 2 a and Fig. 2 b:

Table 3

Natural law	The 0th day	The 13rd day
			Cosmetic variation	The unable vomiting of halitosis	Normal strong
BUN(mg/dL)	158	18
			CRE(mg/dL)	6.7	1.9

Embodiment 3 (dog) house pet name: Kent

Master data: house pet kind: Ha Shiqi dog; Sex: public affairs; Age: 5 years old; 19.6 kilograms of body weight.

The health status of (the 0th day) animal before the administration: the invalid acute renal failure that transfers to of his institute's infusion treatment, the veterinarian advises peritoneum or hemodialysis or euthanasia house pet.

Medicine and mode: directly with the administration of A+B mixed liquor.

Throwing takes therapeutic outcome behind the medical composition provided by the invention in following table 4 and Fig. 3 a and Fig. 3 b:

Table 4

Natural law	The 0th day	The 7th day
			Cosmetic variation	Unable vomiting	Normal strong
BUN(mg/dL)	147	92
			CRE(mg/dL)	9.4	7.3

Embodiment 4 (dog) house pet name: NANA

Master data: house pet kind: Labrador Retriever; Sex: mother; Age: 6 years old; 31.85 kilograms of body weight.

The health status of (the 0th day) animal before the administration: invalid through the transfusion of his institute and subcutaneous injection drug treatment, transfer acute renal failure to, the veterinarian advises peritoneum or hemodialysis or euthanasia house pet.

Medicine and mode: first with the administration of A+B mixed liquor, rose in the 60th day and only to beat extremely once a day 75mL of A liquid and reduction dosage.

Throwing takes therapeutic outcome behind the medical composition provided by the invention in following table 5 and Fig. 4 a and Fig. 4 b:

Table 5

Embodiment 5 (cat) house pet name: JAGUAR

Master data: house pet kind: miscegenation cat; Sex: public affairs; Age: 4 years old; 4.8 kilograms of body weight.

The health status of (the 0th day) animal before the administration: invalid through his institute's infusion treatment, and also fail to respond to any medical treatment through his institute's subcutaneous injection B liquid, chronic renal failure transfers acute renal failure to, and the doctor advises peritoneum or hemodialysis or euthanasia house pet.

Medicine and mode: give first after A liquid a period of time, mixed the administration of A+B liquid subcutaneous injection in the 364th day, then dosage is beaten fewer and fewer.

Throwing takes therapeutic outcome behind the medical composition provided by the invention in following table 6 and Fig. 5 a and Fig. 5 b:

Table 6

Natural law	The 0th day	The 36th day	The 306th day	The 364th day	The 399th day
						Cosmetic variation	Unable	Normal strong	Normal strong	Normal strong	Normal strong
Use liquid	A	A	A	A+B	A+B
						BUN(mg/dL)	140	36	60	Not check	46
CRE(mg/dL)	17.5	4.0	5.8	Not check	4.1

Embodiment 6 (cat) house pet name: limit, limit

Master data: house pet kind: persian cat; Sex: public affairs; Age: 10 years old; 6.1 kilograms of body weight.

The health status of (the 0th day) animal before the administration: invalid through his institute's infusion treatment, and also fail to respond to any medical treatment through his institute's subcutaneous injection B liquid, chronic renal failure transfers acute or chronic renal failure to, and the veterinarian advises peritoneum or hemodialysis or euthanasia house pet.

Medicine and mode: directly with the administration of A+B mixed liquor.

Throwing takes therapeutic outcome behind the medical composition provided by the invention in following table 7 and Fig. 6 a and Fig. 6 b:

Table 7

Natural law	The 0th day	The 14th day	The 21st day
				Cosmetic variation	Unable	Normal strong	Normal strong
BUN(mg/dL)	107	79	88
				CRE(mg/dL)	7.8	7.9	4.6

Embodiment 7 (cat) house pet name: skin skin

Master data: house pet kind: persian cat; Sex: mother; Age: 13 years old; 2.55 kilograms of body weight.

The health status of (the 0th day) animal before the administration: invalid through his institute's infusion treatment, transfer acute renal failure to, the veterinarian advises peritoneum or hemodialysis or euthanasia house pet.

Medicine and mode: directly with the administration of A+B mixed liquor.

Throwing takes therapeutic outcome behind the medical composition provided by the invention in following table 8 and Fig. 7 a and Fig. 7 b:

Table 8

Natural law	The 0th day	The 7th day
			Cosmetic variation	Unablely breathe heavily very much	Normally
BUN(mg/dL)	174	95
			CRE(mg/dL)	10.6	6.8

Embodiment 8 (cat) house pet name: younger sister

Master data: house pet kind: miscegenation cat; Sex: mother; Age: 3 years old; 2.9 kilograms of body weight.

The health status of (the 0th day) animal before the administration: invalid through his institute's infusion treatment acute renal failure, emergency peritoneal dialysis is carried out in veterinarian's suggestion.

Medicine and mode: directly with the administration of A+B mixed liquor, beat fewer and fewer.

Throwing takes therapeutic outcome behind the medical composition provided by the invention in following table 9 and Fig. 8 a and Fig. 8 b:

Table 9

Natural law	The 0th day	The 13rd day	The 58th day	The 86th day
					Cosmetic variation	Unable	Normally	Normally	Normally
BUN(mg/dL)	113	89	34	41
					CRE(mg/dL)	8.7	7.4	4.6	3.5

[0144]Embodiment 9 (cat) house pet name: flower

Master data: house pet kind: miscegenation cat; Sex: mother; Age: 3 years old; 2.6 kilograms of body weight.

The health status of (the 0th day) animal before the administration: invalid through his institute's infusion treatment acute renal failure, the veterinarian advises peritoneum or hemodialysis or euthanasia house pet.

Medicine and mode: the direct subcutaneous injection administration of A+B mixed liquor.

Throwing takes therapeutic outcome behind the medical composition provided by the invention in following table 10 and Fig. 9 a and Fig. 9 b:

Table 10

Natural law	The 0th day	The 15th day	The 25th day
				Cosmetic variation	Unable uncomfortable	Normally	Normally
BUN(mg/dL)	149	82	50
				CRE(mg/dL)	5.0	5.8	4.0

Embodiment 10 (cat) miu is young

Master data: house pet kind: American Shorthair; Sex: public affairs; Age: 4 years old; 3.35 kilograms of body weight.

The health status of (the 0th day) animal before the administration: invalid through his institute's peritoneal dialysis, chronic renal failure transfers acute renal failure to.

Medicine and mode: directly with the administration of A+B mixed liquor, beat fewer and fewer.

Throwing takes therapeutic outcome behind the medical composition provided by the invention in following table 11 and Figure 10 a and Figure 10 b:

Table 11

Embodiment 11 (cat) Liao kitten

Master data: house pet kind: Himalaya; Sex: public affairs; Age: 16 years old; 2.35 kilograms of body weight.

The health status of (the 0th day) animal before the administration: his institute's primary diagnosis is that acute renal failure is not done any disposal, and body and mind is very uncomfortable.

Medicine and mode: the direct subcutaneous injection administration of A+B mixed liquor.

Throwing takes therapeutic outcome behind the medical composition provided by the invention in following table 12 and Figure 11 a and Figure 11 b:

Table 12

Claims (7)

1. medical composition that is used for the treatment of house pet renal failure, it comprises A liquid and B liquid, and wherein, the relative scale of this A liquid and B liquid is 1: 1, and this A liquid and B liquid contain respectively following component and content:

A liquid

B liquid

2. medical composition as claimed in claim 1, it is by the administration of subcutaneous injection mode.

3. medical composition as claimed in claim 1 or 2, wherein, described A liquid and B liquid contain respectively following component and content:

A liquid

B liquid

4. medical composition as claimed in claim 1 or 2, it is for due to illness renal failure treatment.

5. medical composition as claimed in claim 1 or 2, it is for the renal failure emergency treatment.

6. medical composition as claimed in claim 1 or 2, it is be used to continuing to look after treatment.

7. medical composition as claimed in claim 1 or 2, wherein, described A liquid and B liquid use every day 1 to 3 time with the amount of 0.1-10mL/ kg body weight respectively.

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