CN103271794A - Biological antibacterial patch for bedsore surface - Google Patents

Abstract

The invention relates to a biological antibacterial patch for bedsore surface. The composite film patch mainly comprises four layers, namely a bottom breathable base (1) coated with adhesive, a second layer made of nonwoven rayon (2), a third layer made of biological antibacterial dressing (3), and a surface paper isolation layer (4), wherein one end of the bottom breathable base is provided with an easy tear edge (5). The biological antibacterial dressing is made from chitosan, acetic acid, lysozyme, gelatin, clorhexidine acetate, aerosil, and water. The biological bacterial dressing including no any additive has the functions of fine antibiosis, inflammation diminishing, hemostasis, promoting cell growth, promoting wound healing and the like, and has the advantages of high water content, fine water retention, high toughness and good breathability. The biological antibacterial patch for bedsore surface is mainly used for treating bedsores, burns and surgical infections.

Description

Apply ointment or plaster based on the biological antibiotic that bedsore wound is used

Technical field

The present invention relates to a kind of biological antibiotic of using based on bedsore wound and apply ointment or plaster and its production and use, particularly a kind of antibiotic applying ointment or plaster of natural biological of containing the treatment decubital ulcer of chitosan.

Background technology

Decubital ulcer is a kind of common exogenous injury of human body, and decubital ulcer not only causes the damage of skin, and can cause serious systemic reaction, large tracts of land decubital ulcer especially, and general reaction is particularly violent, so early stage correct processing of bedsore wound is the key measure of protecting from infection.

Mainly be to use dry gauze or the wrapping of oily yarn for decubitus wound conventional process way.Dry gauze only plays the effect that supervision covers wound.And wound healing is not had facilitation, and sepage management is limited in one's ability, and the adhesion wound, and newborn epithelial tissue is damaged and causes hemorrhagely, and patient is pain behind the change dressings more.Though oil yarn adhesion wound does not have facilitation to the whole agglutination of wound, invalid to infected wound, the sepage management is limited in one's ability.

The biological antibiotic compound film dressing is a kind of novel wound dressing that development in recent years is got up, compare with used traditional dressing at present etc., aerogel dressing can shorten the time of wound healing, alleviate patient's pain, promote that wound better heals, and air permeable humidity retaining can not destroy the wound tissue of having healed when change dressings more.And material self physics and stable chemical performance are easily preserved.

Summary of the invention

The technical issues that need to address of the present invention are based on the biological antibiotic that bedsore wound uses and apply ointment or plaster, especially at the treatment of degree of depth bedsore wound.

It is strong that a kind of biological antibiotic compound film dressing of the present invention has water absorption, and moisture retention is good, the intensity height, pliability is good, characteristics such as permeability is good, and have antibioticly, can absorb transudate, ventilative, not with the tissue adhesion, antiinflammatory, effects such as hemostasis and promotion wound healing, be that preparation is simple, a kind of biological antibiotic compound film dressing that cost is low.

Technical scheme of the present invention:

Biological antibacterial dressing of the present invention comprises: the biological antibacterial dressing compositions of the gel form for the treatment of effective dose, earlier the biological antibacterial dressing compositions is coated on the nonwoven artificial silk during its preparation, and add ventilative base material and sealing coat then.

Described biological antibacterial dressing combination has:

(a) chitosan: 2～94.445%,

(b) acetic acid: 0.2～5%,

(c) lysozyme: 0.1～25%,

(d) gelatin: 5～20%,

(e) aerosil: 0.25%～4%,

(f) chlorhexidine acetate: 0.005%～0.375%,

(g) water: 0～92.445%.

Above-mentioned biological antibacterial dressing prepares by the following method:

A certain amount of chitosan is dissolved in certain density acetic acid, makes solution a; A certain amount of lysozyme is dissolved in a certain amount of deionized water, makes solution b; Solution a and solution b are mixed stirring, and liquid is uniformly mixed; In mixed liquor, add a certain amount of gelatin, aerosil and chlorhexidine acetate again; Then this biological antibacterial dressing direct part is dewatered or is applied on the carrier nonwoven artificial silk and dewater again, be placed on the rolling cut ad-hoc location on the packer of applying ointment or plaster with scribbling the ventilative base material of binding agent and artificial no spinning that the papery sealing coat has been coated with biological antibacterial dressing in addition, open the rolling cut packer of applying ointment or plaster, with the product excision forming, sterile packaged is preserved.

Foundation of the present invention: by chitosan combination degradation technique, chitosan, degradation of chitosan product and lysozyme are carried out organic complex, reach Synergistic biocidal potentiation purpose; Utilize preserving moisture and film forming characteristics of chitosan, and the nutritional support that provides of gelatin, further promote wound healing and suppress the cicatrix growth; Utilize the lysozyme degradation technique, suppress the oxidation of product in preparation process, keep the activity of biomaterial.

Said chitosan is the derivant of chitin after refining, deacetylated.

Above-mentioned lysozyme is a kind of in staphylococcus lysozyme, endogenous or the exogenous lysozyme or their compound enzyme.

Used chlorhexidine acetate is cationic surfactant, has has a broad antifungal spectrum, characteristics that antibacterial action is stronger, and most Grain-positives and negative bacteria are had killing action.Onset is rapid, effect is lasting; Absorbed by body hardly, therefore have no side effect, life-time service does not develop immunity to drugs.

Acetic acid is mainly used to dissolve chitosan.

Aerosil is a kind of extremely fine nano-scale amorphous fumed silica, and particle diameter is little, even particle size distribution, specific surface area are big, has very high surface activity.The present invention adds fumed silica in prescription, not only effectively thickening, improve product stability, and can improve the thixotropic property of product and the skin sense when using.

Gelatin has the performance that promotes cell adhesion and growth, has good affinity with biological tissue, and it has activated macrophage and hemostatic function, is therefore often made to make wound dressing separately or with other materials is compound.

Polyurethane film is fine porous structure, can only see through the water vapour molecule that particle diameter is about 0.4nm, and to any water droplet, can't pass through because particle diameter is excessive, also intercepting extraneous water when therefore playing the antiseepage effect enters, can allow the steam of body surface evaporation and transudate can be smoothly by and vapor away, and can guarantee that wound is ventilative.If transudate is too much, artificial no spinning (3) can absorb a large amount of transudates, and can keep the moist environment of wound appropriateness, for wound provides better healing environment.

When this biological antibacterial dressing is attached to wound, can kill the various common clinical bacterium of wound fast, form layer protecting film at wound surface simultaneously, have the control traumatic infection, promote wound healing and suppress cicatrix growth effect.

Description of drawings

The invention will be further described below in conjunction with the drawings and specific embodiments.

Accompanying drawing is structural representation of the present invention.

Among the figure, 1. scribble the ventilative base material of binding agent, 2. nonwoven artificial silk, 3. biological antibacterial dressing, 4. papery sealing coat, 5. easy-to-draw corner.

The specific embodiment:

A kind of biological antibiotic composite membrane of the present invention applies schematic cross-sectional view as shown in drawings, comprises that 1. scribble the ventilative base material of binding agent, 2. nonwoven artificial silk, 3. biological antibacterial dressing, 4. papery sealing coat, 5. easy-to-draw corner.

By chitosan, glacial acetic acid, lysozyme, chlorhexidine acetate, deionized water, gelatin, also has silicon dioxide etc., the biologicalantibacterial dressing 3 that makes overlays in the artificial nospinning 2, and theventilative base material 1 that scribbles binding agent is coating artificial nospinning 2 and biologicalantibacterial dressing 3 withpapery sealing coat 4.

The present invention applies ointment or plaster when using, and tears papery sealing coat (4) off from easy-to-draw corner (5), biological antibacterial dressing (3) is adjacent to towards wound get final product.

Embodiment 1-7:

Prepare biological antibacterial dressing according to following ratio:

?	1	2	3	4	5	6	7
								Chitosan	2	4	6	8	10	12	14
Lysozyme	2	2	2	2	2	3	4
								Gelatin	2	4	6	8	10	12	14
Aerosil	0.25	0.25	0.25	0.25	0.25	0.35	0.5
								Chlorhexidine acetate	0.05	0.05	0.1	0.1	0.1	1	1

The biological antibacterial dressing of above-described embodiment to the sterilizing rate of escherichia coli, bacillus pyocyaneus, golden staphylococci, Candida albicans all greater than 90%.

Claims (4)

1. the biological antibiotic of using based on bedsore wound is applied ointment or plaster, it is characterized in that: the end at the ventilative base material of having of coating adhesive (1) is provided with easy-to-draw corner (5), be artificial no spinning layer (2) above, scribble biological antibacterial dressing (3) at artificial no spinning layer (2), the top layer is papery sealing coat (4); The described biological antibiotic of using based on bedsore wound is applied ointment or plaster, and it is characterized in that, each component percentages content of biological antibacterial dressing is:

(a) chitosan: 2～94.445%,

(b) acetic acid: 0.2～5%,

(c) lysozyme: 0.1～25%,

(d) gelatin: 5～20%,

(e) aerosil: 0.25%～4%,

(f) chlorhexidine acetate: 0.005%～0.375%,

(g) water: 0～92.445%.

2. the biological antibiotic of using based on bedsore wound as claimed in claim 1 is applied ointment or plaster, and it is characterized in that: described breathability base material is polyurethane film.

3. the biological antibiotic of using based on the bedsore wound preparation method of applying ointment or plaster is characterized in that: comprise the steps:

A, a certain amount of chitosan is dissolved in certain density acetic acid, makes solution a;

B, a certain amount of lysozyme is dissolved in a certain amount of deionized water, makes solution b;

C, solution a and solution b mixed stir, liquid is uniformly mixed;

D, in mixed liquor, add a certain amount of gelatin, aerosil and chlorhexidine acetate again;

E, treat that swelling behavior fully after, direct part dehydration or be applied to dehydration again on the carrier nonwoven artificial silk;

The artificial no spinning that f, the ventilative base material that will scribble binding agent and papery sealing coat have been coated with biological antibacterial dressing in addition is placed on the rolling cut ad-hoc location on the packer of applying ointment or plaster, and opens the rolling cut packer of applying ointment or plaster, with the product excision forming;

G, sterile packaged, preservation.

4. the biological antibiotic of using based on the bedsore wound as claimed in claim 3 preparation method of applying ointment or plaster is characterized in that: described dewatering type is that vacuum drying, heat drying or machinery are pressed and removed.

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