CN102973986A - Medical super-lubricity antibacterial catheter coating liquid - Google Patents

Abstract

The invention discloses a medical super-lubricity antibacterial catheter coating liquid. The coating liquid consists of lubricating liquid and antibacterial substance, wherein the lubricating liquid is prepared through dissolving hydrophilic polymer in organic solvent and adding adhesive polymer at the same time; and the antibacterial substance consists of nano-silver or other nano materials, iodine or iodine compounds, chitin or chitosan and derivatives thereof. The coating liquid is directly soaked or sprayed on a catheter surface through one step when being used, and after solidification, a medical super-lubricity antibacterial catheter is prepared. The coating liquid has double effects of super lubricity and antibiosis, the coating liquid preparation and a coating method are simple, and the coating liquid is easy for mass production. The coated product has strong lubricity, and the coating liquid has an antibacterial function and no drug resistance and can prevent various bacteria and fungi infections and related complications from being generated. The medical super-lubricity antibacterial catheter coating liquid is suitable for the medical field and has good popularization and use values.

Description

A kind of superslide antibiotic medical catheter coating solution

Technical field

The present invention relates to field of medical materials, be specifically related to the composition for the coating solution of medical equipment, the superslide anti-microbial catheter of this coating solution that related to simultaneously the preparation and application of coating solution and coating.

Background technology

The conduit that medically uses at present comprises the multiple inside and outside conduits such as catheter, stomach tube, anus catheter, tracheal intubation, sputum aspirator tube, nasal intubation, vascular catheterization, it is one of medical device commonly used in the modern medical service practice such as Medical urethral catheter, general catheter all is to make with simple medical rubber tube, silica gel tube and polyvinyl chloride hose, for the smooth and easy power of reducing friction of use procedure, generally can be coated with lubricant at the catheter leading portion, its consumption and operation be difficult assurance, increases foul link more for operation; In addition, the catheter surface easily adheres to antibacterial, in the urethral catheterization process, very easily infect, thus for the infection meeting patient is carried out antibiotic prevention and treatment, and antibiotic can be to human body generation harm to a certain degree.

Therefore, reduce conduit skin-friction force, improve its hydrophilic and infection function be conduit production and use in a key issue needing to be resolved hurrily.

Summary of the invention

In order to solve the defective in the existing product, the object of the present invention is to provide and a kind ofly can reduce catheter surface frictional force, and have the medical catheter coating solution of the antibiotic dual-use function of superslide.This coating solution has the preferably part or all of function of biocompatibility, lubricity, adhesiveness and antibacterial action.

Another object of the present invention is to provide the preparation method of above-mentioned medical catheter coating solution, and the method technique is simple, and preparation cost is low, and product stability is good, and is pollution-free, easy to use, is applicable to medical material, particularly the modification field of catheter.

The present invention has adopted following technical scheme:

This superslide antimicrobial coating liquid is by forming lubricating fluid and common mixing of antibiotic substance.Lubricating fluid is comprised of following all or part of material by weight percentage:

Organic solvent: 70-99.3%.Be selected from one or more in toluene, ethanol, methanol, propanol, isopropyl alcohol, acetone, butanone, acetonitrile, ethyl acetate, ethylene carbonate, dimethyl sulfoxide, oxolane, chloroform, dichloromethane, Ketohexamethylene, cyclohexane extraction, heptane, acetic acid, lactone, ethylene glycol butyl ether, acetic acid Arrcostab, collodion, N-N dimethyl formamide, the dimethyl acetylamide etc.

Hydrophilic polymer: 0.1-10%.Be selected from one or more of polyvinyl alcohol, polyethylene glycol oxide, Polyethylene Glycol, hydroxyethyl methylacrylate, poly hydroxy ethyl acrylate, 2-(Acryloyloxy)ethanol, Poly(Hydroxyethyl Methacrylate), polyvinylpyrrolidone, glycerol, ethylene glycol, NVP, acrylic acid, acrylate, polyacrylic acid and salt thereof, maleic anhydride, acrylamide, polyacrylamide or PVP-VA apoplexy due to endogenous wind.

Adhesiveness polymer: 0.1-10%.Be selected from polylactic acid, polyester, one or more in the performed polymer of polyether-ketone, polrvinyl chloride, polyurethane, polyurethane and polyester etc., Oleum Ricini, Camphora, dibutyl phthalate, alkyl resin, silicone rubber, polyethylene, benzophenone, styrene polybutadiene, acrylic resin, Merlon, dibutyl sebacate, the polyvinyl butyral resin etc.

Antibiotic substance is comprised of following all or part of material by weight percentage:

Antibacterial: 0.5-10%.Be selected from nanometer silver or other nano materials, iodine or iodine compound, one or more in chitin or chitosan and the derivant thereof etc.

In the technique scheme, described superslide antimicrobial coating liquid is directly used in the coating of conduit, and oven dry gets final product.

The present invention adopts above-mentioned technical scheme, and its advantage and benefit are:

1. what this medical catheter adopted is super lubrication technology, hydrophilic polymer organically is combined in the outer surface of catheter, its meet water super lubricating film, lubricant effect surpasses the conventional lubrication method, greatly reduce the damage to mucous membrane of urethra, reduced urethral secretions and mineralization, safety, health, convenient.The hydrophilic polymer that adopts facts have proved that through years of researches these all are to have good hydrophilic and biocompatible polymer, and itself is all nontoxic in human body with its catabolite.

2. the antibacterial action of this medical catheter is to form by comprising nanometer silver or other nano materials, iodine or iodine compound, chitin or chitosan and derivant thereof.The nanometer silver antimicrobial spectrum is wide, commute causes that the tens of kinds of pathogenic microorganism such as the escherichia coli, staphylococcus aureus, gonococcus, chlamydia trachomatis of urethra inflammation have strong inhibition and killing action, and nanometer silver is the physical antibacterial method, does not produce drug resistance, and antibiotic safety is good.

Iodine or iodine compound have powerful sterilization biological activity and kill the pathogen effect, it can make the protein generation degeneration of pathogen, it can kill bacteria, fungus, virus, ameba etc., can be used to treat many bacillary, fungoids, the dermatosis such as viral, and these chemical compounds are not only antibiotic, also have very strong water solublity, odorlessness is to characteristics such as skin nonirritants.

Chitin is extensively to be distributed in natural polysaccharide, is the main component of animal shell.Chitosan is the deacetylated product of chitin; the chitin commute causes that the antibacterials such as the escherichia coli, staphylococcus aureus, Candida albicans of urethra inflammation have good fungistatic effect; and this anti-biotic material of chitin and chitosan is naturally occurring; reliable to human-body safety, have no side effect.

3. lubricated during the catheter coatings dry state, be easy to encapsulation, keeping and transportation, just can show superpower lubricity a moment but only in distilled water or normal saline, infiltrate before use, be convenient to the doctor and operate.

4. used the adhesiveness polymer in the coating solution of this medical catheter, can make coating solution be attached to securely catheter surface, difficult drop-off.

5. structural design advantages of simple of the present invention, coating process is simple, and is workable, is a kind of good renewal product, is suitable for promoting the use of.When catheter was implanted, hydrophilic polymer provided lubrication, the convenient insertion; And antibiotic substance is brought into play simultaneously lasting inhibition and is killed the effects of pathogenic bacterium.

The specific embodiment

The invention will be further described below in conjunction with specific embodiment, but the scope of protection of present invention is not limited to the related scope of embodiment.

The following embodiment of the preparation process of medical catheter coating solution:

Embodiment 1

1. get polyvinylpyrrolidone 2g, pyroxylin 0.5g, Oleum Ricini 1g, toluene 5 mL, ethyl acetate 2 mL, acetone 10 mL, ethanol 20 mL, isopropyl alcohol 1 mL, acetic acid 0.5 mL, oxolane 2 mL, polyester 1 g, PVP-I 0.5 g is mixed with coating solution.Conduit is immersed in 1-60 s in the coating solution, takes out, in 30-70 ℃ of oven dry 5-30min, afterwards sealing is preserved.

 

Embodiment 2

2. get sodium polyacrylate 2g, polrvinyl chloride 1g, Ketohexamethylene 10 mL, toluene 5 mL, oxolane 2 mL, ethyl acetate 2 mL, ethanol 10 mL, butanone 20 mL, methanol 3 mL, heptane 10 mL, nanometer silver powder 0.5g is mixed with coating solution, and conduit is immersed in 1-60 s in the coating solution, takes out, in 30-70 ℃ of oven dry 5-30min, afterwards sealing is preserved.

 

Embodiment 3

3. get polyacrylamide 2.0g, ethanol 10 mL, butanone 10 mL, oxolane 2 mL, isopropyl alcohol 1 mL, polyester 0.2g, Oleum Ricini 0.2g, collodion 0.5g, nanometer silver powder 0.3g is mixed with coating solution.Catheter is immersed in 1-60s in the coating solution, takes out, in 30-70 ℃ of oven dry 5-30min, afterwards sealing is preserved.

 

Embodiment 4

4. taking polyethylene glycol 2.0g, N-N dimethyl formamide 5 mL, toluene 2 mL, methanol 10 mL, acetone 5 mL, acetone 10 mL, Merlon 2g, polyethylene 2g, chitosan powder 0.2g is mixed with coating solution.Catheter is immersed in 1-60s in the coating solution, takes out, in 30-70 ℃ of oven dry 5-30min, afterwards sealing is preserved.

Claims (10)

1. superslide antibiotic medical catheter coating solution, it is characterized in that: this coating solution is comprised of lubricating fluid and antibiotic substance two parts, and wherein the component of lubricating fluid is generally:

Organic solvent: 70-99.3%

Hydrophilic polymer: 0.1-10%

Adhesiveness polymer: 0.1-10%

Antibiotic substance concentration is generally 0.5-10%.

2. superslide antibiotic medical catheter coating solution according to claim 1, be further characterized in that: this coating solution also can be comprised of the independent component of lubricating fluid, and the conduit that uses this lubricating fluid coating is a kind of superslide medical catheter.

3. superslide antibiotic medical catheter coating solution according to claim 1, be further characterized in that: described hydrophilic polymer is selected from polyvinyl alcohol, polyethylene glycol oxide, hydroxyethyl methylacrylate, poly hydroxy ethyl acrylate, 2-(Acryloyloxy)ethanol, Poly(Hydroxyethyl Methacrylate), polyvinylpyrrolidone, glycerol, ethylene glycol, Polyethylene Glycol, NVP, acrylic acid, acrylate, polyacrylic acid and salt thereof, maleic anhydride, acrylamide, polyacrylamide or one or more combinations of PVP-VA class.

4. superslide antibiotic medical catheter coating solution according to claim 1, be further characterized in that: described organic solvent is selected from one or more combinations in toluene, ethanol, methanol, propanol, isopropyl alcohol, acetone, butanone, acetonitrile, ethyl acetate, ethylene carbonate, dimethyl sulfoxide, oxolane, chloroform, dichloromethane, Ketohexamethylene, cyclohexane extraction, heptane, acetic acid, lactone, ethylene glycol butyl ether, acetic acid Arrcostab, collodion, N-N dimethyl formamide, the dimethyl acetylamide etc.

5. superslide antibiotic medical catheter coating solution according to claim 1 is further characterized in that: one or more combinations in the performed polymer of described adhesiveness polymer selection polrvinyl chloride, polylactic acid, benzophenone, polyether-ketone, Oleum Ricini, Camphora, polyester, polyurethane, polyurethane and polyester etc., dibutyl phthalate, alkyl resin, silicone rubber, polyethylene, styrene polybutadiene, acrylic resin, Merlon, dibutyl sebacate, the polyvinyl butyral resin etc.

6. superslide antibiotic medical catheter coating solution according to claim 1, be further characterized in that: described antibiotic substance is selected from one or more combinations in nanometer silver or other nano materials, iodine or iodine compound, chitin or chitosan and the derivant thereof.

7. superslide antibiotic medical catheter coating solution according to claim 1 is characterized in that described lubricating fluid directly by organic solvent dissolution hydrophilic polymer and adhesiveness polymer lubricating fluid, also can by corresponding monomer polymerization, be prepared into lubricating fluid.

8. superslide antibiotic medical catheter coating solution according to claim 1 is characterized in that described coating solution is formed by directly mixing by lubricating fluid and antibiotic substance.

9. superslide antibiotic medical catheter coating solution according to claim 1 is characterized in that described coating solution in use, and directly with coating solution dipping or be sprayed at catheter surface, one-step method can be finished coating, and oven dry gets final product.

10. superslide antibiotic medical catheter coating solution according to claim 1, it is characterized in that this coating solution except using with the coating of catheter, also can be used for the coating of the multiple inside and outside conduits such as stomach tube, anus catheter, tracheal intubation, sputum aspirator tube, nasal intubation, vascular catheterization.