CN102955019A

Movatterモバイル変換

Info

Publication number: CN102955019A
Application number: CN2011102359585A
Authority: CN
Inventors: 聂富强
Original assignee: BEIJING HUAKAIRUI MICROFLUIDIC CHIP TECHNOLOGY Co Ltd
Current assignee: BEIJING HUAKAIRUI MICROFLUIDIC CHIP TECHNOLOGY Co Ltd
Priority date: 2011-08-17
Filing date: 2011-08-17
Publication date: 2013-03-06

Abstract

The invention relates to a water quality on-line monitoring system and its preparation method. The core component of the monitoring system is a microfluidic chip platform, which integrates high-throughput data acquisition, information processing and transmission, automated analysis and monitoring, network remote control and other key functional units to form a micro-total chip analysis system. On the chip platform, four core technologies, i.e. integration, multi-functionalization, analysis detection and networking are realized. The water quality on-line monitoring system with a microcomputer central processing system as the center can be formed. By physical, chemical, biological or other analysis means, the functions of water quality routine monitoring, emergency treatment and early warning can be achieved.

Description

A kind of monitoring water quality on line system and preparation method thereof

Technical field

The present invention relates to a kind of water analysis detection system based on the micro-fluidic chip technology, this system takes full advantage of micro-fluidic chip and is easy to the characteristics that each functional unit is integrated, integrated form, multifunction, analyzing and testing, four core technologies of networking are incorporated on the small-sized micro-fluidic chip platform, by physics, chemistry or bioanalysis means, integrate high flux data acquisition, information processing and the functional units such as transmission, automated analysis and monitoring and network remote control, form the chip micro-total analysis system, water quality is analyzed and monitored.

Background technology

Along with the socioeconomic excessive exploitation that develops rapidly with environmental resource, water pollution problem is day by day serious.Situation based on environmental pollution and the deterioration of the ecological environment of present sternness; and the harmfulness of a lot of environment accidents; country and the water quality protection of common people's growing interest, routine monitoring and pre-alarm and prevention; yet; the automatic monitoring system of high-quality and pollution source real-time online continuous monitor system but very lack; mostly China's water quality monitoring instrument is that medium and small sized enterprises produce; product concentrates on low and middle-grade water quality monitoring instruments substantially, far can not adapt to the needs of present water quality monitoring, emergent and early warning job development.Development water quality routine and water quality accident monitoring instrument and equipment thereof are to realize the monitoring technology modernization, and the important guarantee of accurate information is provided for environmental protection, public health and sustainable economic development.Water quality monitoring system has central station and dials with phone via satellite and hold several substations formations that two kinds of communication modes are realized real time monitoring, Long-distance Control and data-transformation facility in the month at present.Each substation is the water quality monitoring system of an independent completion, generally consisted of by 6 main subsystems, comprising: sampling system, pretreatment system, monitoring instrument system, PLC control system, data sampling and processing and transmission subsystem and remote data management center, monitoring station or monitoring cabin.The constituted mode of the substation in the water quality monitoring system roughly has three kinds: the substation (many combinations can be used for measuring the water quality of different water depth) that (1) is comprised of one or more small-sized multi-parameter water quality automatic analyzer (as: routine five parameter analyzers of YS1 company and HYDROLAB company).(2) fixed substation: be more traditional system's building form.(3) flow-type substation: a kind ofly all be loaded on the trailer (monitoring cabin) for fixed substation instrument and equipment, can move as required the place, also can think the semi-fixed type substation.Be characterized in forming cost higher.Each unit is realized connecting each other by water sample delivery pipeline system, signal transmission system, compressed air conveying pipeline system, pure water delivery pipeline system.The present this monitoring water quality on line component of a system is complicated, the on-line analysis detectability is poor, unit interval Treatment Analysis sample capability is low, system takes up an area greatly, cost performance is low, application function is single, automaticity is low and be difficult to realize portable on-the-spot real time on-line monitoring.

Therefore, to the water quality on-line real time monitoring, emergent and early warning is extremely urgent, people urgently wishes to have a kind ofly can carry out continuously water quality, the high-quality automated system of quick, on-line monitoring.In recent years, micro-fluidic chip has microminiaturization, robotization, the advantage such as integrated, convenient and quick as a kind of novel analysis platform, obtain a wide range of applications fields such as cell biology, analytical chemistry, materialogy, organizational project and microelectronics in a lot of fields.Yet, with the monitoring water quality on line system of micro-fluidic chip as the analyzing and processing product platform, by physics, chemistry or bioanalysis means, integrate high flux data acquisition, information processing and the functional units such as transmission, automated analysis and monitoring and network remote control, form the chip micro-total analysis system, water quality is analyzed and monitored, in application substantial breakthrough is arranged not yet at present.

Summary of the invention

The objective of the invention is design and prepare a kind of monitoring water quality on line system, it is characterized in that this system can analyze all kinds of water quality of monitoring real-time, convenient, quickly and accurately.Integrated form, multifunction, analyzing and testing, four core technologies of networking are incorporated into the micro-fluidic chip platform, form the monitoring water quality on line system, realize water quality routine monitoring, emergency processing and warning function.Physics, chemistry or bioanalysis means are integrated on the small-sized micro-fluidic chip, form the chip micro-total analysis system, integrate high flux data acquisition, information processing and the functional units such as transmission, automated analysis and monitoring and network remote control, water quality is analyzed and monitored.

For achieving the above object, the present invention adopts following operation steps:

1. Computer-aided design software (CAD) designs and draws the preparation figure of micro-fluidic chip.

2. the graphics chip for preparing the CAD design by micro-processing technology at the substrate surface of micro-fluidic chip.

With obtain after the chip substrates cutting up and down two micro-fluidic chips (5 * 5cm), after cleaning successively with ethanol, deionized water, ethanol, naturally dry.

4. the function elements such as high flux data acquisition, information processing and transmission, automated analysis and monitoring and network remote control are assembled in the corresponding chip unit.

5. high flux data acquisition, information processing are linked to each other with above-mentioned each function element with the utility appliance of monitoring with function elements such as network remote controls with transmission, automated analysis.

6. layers of chips is carried out involution, the compositing chip micro-total analysis system up and down.

7. microfluid is carried Micropump, analyzing and testing workstation and MICROCOMPUTER PROCESSING center to connect, be assembled into the monitoring water quality on line system.

Among the present invention, the core component of monitoring water quality on line system is the micro-fluidic chip platform.

Among the present invention, the micro-fluidic chip base material can be quartz, glass, silicon materials, high molecular polymer and metal material.

Among the present invention, the microchannel network on the micro-fluidic chip can be by numerical control mill quarter, laser ablation, LIGA technology, method of molding, pressure sintering, chemical corrosion, and also the micro-processing method such as available soft lithography prepares at substrate surface.

Among the present invention, the size of the microanalysis passage of micro-fluidic chip can be wide approximately 200-400 micron, dark approximately 20-50 micron, and length is the 5-20 millimeter approximately, and small size has determined that needed detected amount of samples is few.

Among the present invention, can highly integrated hundreds and thousands of micro channel arrays on the micro-fluidic chip, a large amount of analyzing water body quality at short notice, and can obtain rapidly and accurately kind and the concentration information of pollutant in the water body, detection efficiency is the hundreds of times of classic method.

Among the present invention, the encapsulation of micro-fluidic chip can cause double-deck adhesive film involution by heat sealing, adhesive involution, the auxiliary involution of surface active, power.

Among the present invention, the detection mechanism of monitoring water quality on line system can be based on all kinds of detection meanss of physics, chemistry or bioanalytical method, depends on the kind of on-the-spot water quality and pollutant.

Among the present invention, the function elements such as high flux data acquisition, information processing and transmission, automated analysis and the monitoring in the water quality monitoring process and network remote control are the corresponding function zones that is integrated on the small-sized micro-fluidic chip.

Among the present invention, the monitoring water quality on line system can realize at the micro-fluidic chip platform integration of integrated form, multifunction, analyzing and testing, four core technologies of networking.

Among the present invention, the monitoring water quality on line system can realize water quality routine monitoring, emergency processing and early warning three large functions.

Among the present invention, the monitoring water quality on line system can realize on-the-spot real-time online continuous monitoring function.

Among the present invention, the monitoring water quality on line system can be connected the MICROCOMPUTER PROCESSING center and connect formation center-radial network type control monitoring system.

Among the present invention, the monitoring water quality on line system can process system by centre data collection and data management, finish data and process the functions such as automatic calculating, report generation, information inquiry, statistical study, realize water quality monitoring, emergent and early warning effective management and dynamic monitoring for information about, the function automation services such as briefing, raw readings, data calculating, report, data statistic analysis are provided for all kinds of post personnel, for water quality management and decision-making section provide faster, upgrade, more accurate polluted information, and decision-making foundation and order traffic directing tool.

The monitoring water quality on line system that the present invention proposes, have simple to operate, applied widely, the characteristics such as degree of accuracy is high, multi-functional unit is integrated on chip, system's portable and operation automation, can under the control of central MICROCOMPUTER PROCESSING and command centre, realize routine monitoring, emergency processing and early warning to water quality.This system has overcome that traditional water quality monitoring system member is complicated, the on-line analysis detectability is poor, unit interval Treatment Analysis sample capability is low, the shortcomings such as large, that cost performance is low, application function is single are taken up an area in system, has broad application prospects in water quality monitoring, emergent and early warning field.Set up national, provincial, city-level and level Four emergency commading system at county level by network, realization information is reported and submitted, instruction transmission and information resources are shared, for related personnel, expert, leader provide situation evaluation information and analysis means, and the supports such as communication and order commander, increase water quality work efficiency and accuracy and the standardization of monitoring department, the increase water quality science of routine monitoring, emergent, early warning decision is for realizing that monitoring water quality on line provides important foundation and technological breakthrough.

Description of drawings

A is the planimetric map of upper chip among Fig. 1, and b is the adhesive membrane planimetric map, and c is the planimetric map of lower chip.Among Fig. 1, lower chip (a) main body is comprised of hole, microchannel and cell window.There is sample holes (A) in the hole, waste liquid hole (G).Cell window has high flux data acquisition (B), information processing and transmission (C), automated analysis and monitoring (D), network remote control (E) and MICROCOMPUTER PROCESSING center (F).Among Fig. 1, chips (b) main body is that double-deck power causes adhesive membrane, is positioned over up and down chip chamber, carries out the involution of chip.Among Fig. 1, upper chip (c) main body is each functional unit and utility appliance connector, the sample holes interface (A '), waste liquid hole interface (G ').Cell window has high flux data acquisition interface (B '), information processing and transmission interface (C '), automated analysis and monitoring interface (D '), network remote control interface (E ') and MICROCOMPUTER PROCESSING hub-interface (F ').The microchannel mainly is microfluidic channel.

Fig. 2 is the workflow of monitoring water quality on line of the present invention system.

Specific embodiments

Embodiment 1:

Computer-aided design (CAD) is drawn the design configuration of micro-fluidic chip, and (5 * 5cm) surface etch goes out required microchannel network at two sheet glass up and down to use photoetching-chemical corrosion method again.After glass detersive, ethanol, deionized water, acetone, ethanol cleaning, room temperature is dried.The function elements such as high flux data acquisition, information processing and transmission, automated analysis and monitoring and network remote control are integrated on the small-sized micro-fluidic chip.High flux data acquisition, information processing are linked to each other with above-mentioned each function element with the utility appliance of monitoring with function elements such as network remote controls with transmission, automated analysis.Layers of chips is carried out involution, the compositing chip micro-total analysis system up and down.Carry Micropump, analyzing and testing workstation and MICROCOMPUTER PROCESSING center to connect microfluid, be assembled into the monitoring water quality on line system.

Embodiment 2:

Computer-aided design (CAD) is drawn the design configuration of micro-fluidic chip, then laser printer gets figure as photomask, uses the quasi-molecule laser etching machine at the required chip microchannel network of organic polymer base material surface (such as polymethylmethacrylate) preparation again.After the cutting of organic polymer base material, after ethanol, deionized water, ethanol cleaning, naturally dry, obtain up and down two organic macromolecule chips (5 * 5cm).The function elements such as high flux data acquisition, information processing and transmission, automated analysis and monitoring and network remote control are integrated on the small-sized micro-fluidic chip.High flux data acquisition, information processing are linked to each other with above-mentioned each function element with the utility appliance of monitoring with function elements such as network remote controls with transmission, automated analysis.Layers of chips is carried out involution, the compositing chip micro-total analysis system up and down.Carry Micropump, analyzing and testing workstation and MICROCOMPUTER PROCESSING center to connect microfluid, be assembled into the monitoring water quality on line system.

Embodiment 3:

Computer-aided design (CAD) is drawn the design configuration of micro-fluidic chip, with numerical control CNC micro-machining system required microchannel network graphic is milled to carve to be machined in organic polymer base material surface (polycarbonate).After organic polymer base material detersive, deionized water, ethanol, deionized water, ethanol cleaning, naturally dry, obtain up and down two organic macromolecule chips (5 * 5cm).The function elements such as high flux data acquisition, information processing and transmission, automated analysis and monitoring and network remote control are integrated on the small-sized micro-fluidic chip.High flux data acquisition, information processing are linked to each other with above-mentioned each function element with the utility appliance of monitoring with function elements such as network remote controls with transmission, automated analysis.Layers of chips is carried out involution, the compositing chip micro-total analysis system up and down.Carry Micropump, analyzing and testing workstation and MICROCOMPUTER PROCESSING center to connect microfluid, be assembled into the monitoring water quality on line system.

Claims

1. monitoring water quality on line system and preparation method thereof, it is characterized in that this system is incorporated into the micro-fluidic chip platform with integrated form, multifunction, analyzing and testing, four core technologies of networking, form the monitoring water quality on line system, realize water quality routine monitoring, emergency processing and warning function.Physics, chemistry or bioanalysis means are integrated on the small-sized micro-fluidic chip, form the chip micro-total analysis system, integrate high flux data acquisition, information processing and the functional units such as transmission, automated analysis and monitoring and network remote control, water quality is analyzed and monitored.

2. by monitoring water quality on line claimed in claim 1 system and preparation method thereof, its characterization step is as follows successively:

(1) the preparation figure of Computer-aided design software (CAD) design and drafting micro-fluidic chip;

(2) prepare the graphics chip that CAD designs by micro-processing technology at the substrate surface of micro-fluidic chip;

(3) with obtain after the chip substrates cutting up and down two micro-fluidic chips (5 * 5cm), after cleaning successively with ethanol, deionized water, ethanol, naturally dry;

(4) function elements such as high flux data acquisition, information processing and transmission, automated analysis and monitoring and network remote control are assembled in the corresponding chip unit;

(5) high flux data acquisition, information processing are linked to each other with above-mentioned each function element with the utility appliance of monitoring with function elements such as network remote controls with transmission, automated analysis;

(6) layers of chips is carried out involution, the compositing chip micro-total analysis system up and down;

(7) microfluid is carried Micropump, analyzing and testing workstation and MICROCOMPUTER PROCESSING center connect, be assembled into the monitoring water quality on line system.

3. by claim 1 or 2 described monitoring water quality on line systems and preparation method thereof, it is characterized in that the core devices of this monitoring water quality on line system is based on small-sized micro-fluidic chip.

4. by claim 1 or 2 described monitoring water quality on line systems and preparation method thereof, it is characterized in that the detection mechanism of this water quality monitoring system is based on physics, chemistry or biological analysis means.

5. by claim 1 or 2 described monitoring water quality on line systems and preparation method thereof, it is characterized in that the function elements such as high flux data acquisition, information processing and transmission, automated analysis and monitoring and network remote control are integrated on the small-sized micro-fluidic chip.

6. by claim 1 or 2 described monitoring water quality on line systems and preparation method thereof, it is characterized in that this monitoring water quality on line system can realize integrated form, multifunction, analyzing and testing, four integration of core technology on the micro-fluidic chip platform of networking.

7. by claim 1 or 2 described monitoring water quality on line systems and preparation method thereof, it is characterized in that this monitoring water quality on line system can realize water quality routine monitoring, emergency processing and warning function.

8. by claim 1 or 2 described monitoring water quality on line systems and preparation method thereof, it is characterized in that this monitoring water quality on line system can realize on-the-spot real time on-line monitoring function.

9. by claim 1 or 2 described monitoring water quality on line systems and preparation method thereof, it is characterized in that this monitoring water quality on line system can be connected the MICROCOMPUTER PROCESSING center and connect formation center-radial network type control monitoring system.

10. by claim 1 or 2 described monitoring water quality on line systems and preparation method thereof, it is characterized in that this system can overcome the shortcomings such as traditional water quality monitoring system member is complicated, the on-line analysis detectability is poor, unit interval Treatment Analysis sample capability is low, system takes up an area greatly, cost performance is low, application function is single, can be under the control of central MICROCOMPUTER PROCESSING and command centre, realize the conventional on-line monitoring of water quality, emergency processing and warning function, have broad application prospects in the water quality monitoring field.