CN102908134A - A parameter calibration method and system for continuous monitoring of cardiac output - Google Patents
A parameter calibration method and system for continuous monitoring of cardiac outputDownload PDFInfo
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Abstract
Description
Technical field
The present invention relates to the technical field of medical treatment detection and parametric calibration, be specifically related to a kind of parameter calibrating method and system of cardiac output continuous monitoring
Background technology
Cardiac output refers to the total blood volume that per minute one side ventricle penetrates, and is the product of heart rate and stroke volume, is the crucial clinical indices of describing the cardiovascular system state.In clinical, especially in operating room, ICU, heart or vascular interventional treatment, cardiac output or stroke volume can help medical personnel to know patient's heart body, and the continuous monitoring of kinemic variation is helped to obtain instant kinemic variation, therefore the continuous monitoring of cardiac output or stroke volume just seemed particularly important with quick response.At present, be used for a lot of to kinemic method for continuous measuring, different according to the principle of equipment and structure, with and the difference of mode of operation, existing kinemic measuring method mainly is divided into noinvasive and Wicresoft's two classes.
Noninvasive measuring method, for example: bioimpedance (ICG), this is a kind of dynamic change according to the thoracic cavity electrical impedance, measures the noninvasive method of cardiac function.This method capacity of blood vessel or blood flow change with the breast impedance variation between set up model, but because the breast impedance variation that body moves, breathing, mechanical ventilation, obesity, edema etc. may cause equally, so accuracy is lower; And for example: the sphygmogram method, its contour feature that is based on the arterial pulse waveform is analyzed, and calculates cardiac output by the model between different wave and the cardiac output.Because different patients' pulse wave profile is different, especially the pulse wave profile of cardiovascular disease initiation unusually also is to cause the method to measure the reason of difficulty; Therefore noninvasive measuring method is subjected to the interference of various factors easily, and accuracy is lower mostly;
The kinemic method of the continuous measurement of Wicresoft, needing will be with among the conduit that is connected of pressure transducer punctures into tremulous pulse, and is stranded in for a long time in the body, and is comparatively complicated to patient's injury and operation easily
Summary of the invention
For overcoming defects, purpose of the present invention namely is to provide a kind of parameter calibrating method and system of cardiac output continuous monitoring.
The objective of the invention is to be achieved through the following technical solutions:
The parameter calibrating method of a kind of kinemic continuous monitoring of the present invention comprises:
By the blood vessel emission two-way different wave length signal of luminescent device to measured target, receive through the two ways of optical signals behind the described blood vessel; Simultaneously, the blood vessel of the conduit access measured target of pressure transducer, measurement standard cardiac output will be connected to;
This two ways of optical signals is converted to the corresponding signal of telecommunication, and amplifies respectively with processing and obtain two-way pulse wave data signal;
Two-way pulse wave data signal is calculated, obtained the regional blood flow of one-period;
Calculate the mapping relations between standard cardiac output and the regional blood flow, and set up physiological models according to these mapping relations;
After setting up physiological models, withdraw from the conduit that the blood vessel with measured target joins, and continue by the continuous blood vessel emission two-way different wave length signal to measured target of luminescent device, until obtain continuous pulse wave data signal.
Further, the described mapping relations that calculate between standard cardiac output and the regional blood flow, and set up physiological models according to these mapping relations and also comprise:
Mapping relations between calculating standard cardiac output and the regional blood flow are set up physiological models according to these mapping relations, and to this physiological models storage;
Judge whether again to calculate mapping relations, if need again to calculate, the two ways of optical signals after then again entering the measurement standard cardiac output and receiving the described blood vessel of process; If do not need again to calculate, then all stored physiological models are averaged, and upgrade physiological models according to average result.
Further, described continuation is by the continuous blood vessel emission two-way different wave length signal to measured target of luminescent device, until obtain comprising after the continuous pulse wave data signal:
The pulse frequency value that from continuous pulse wave data signal, obtains, and to the continuous pulse wave data signal calculating after adjusting, obtain continuous regional blood flow;
Continuous regional blood flow is combined with physiological models, calculates continuous stroke volume;
Utilize continuous stroke volume and pulse frequency value to calculate, obtain continuous cardiac output.
Further, described obtaining comprises after the continuous cardiac output:
Continuous cardiac output is shown and/or prints and/or store.
Further, described obtaining comprises after the continuous cardiac output:
Judge that continuous cardiac output whether in preset range, if not in preset range, then carries out labelling to this continuous cardiac output.
Further, described two-way different wave length signal comprises: red signal light and infrared signal.
A kind of kinemic continuous monitor system of the present invention comprises:
Photosignal sending and receiving module, described photosignal sending and receiving module is attached on the blood vessel of measured target, be used for by the blood vessel emission two-way different wave length signal of luminescent device to measured target, and receive through the two ways of optical signals behind the described blood vessel, this two ways of optical signals is converted to the corresponding signal of telecommunication;
Standard cardiac output measurement module, the blood vessel of described standard cardiac output measurement module and measured target joins, comprise: interconnective standard cardiac output computer, pressure transducer, described pressure transducer gathers standard cardiac output information by conduit, calculates the standard cardiac output by the standard cardiac output computer again; And after setting up physiological models, withdraw from the conduit that the blood vessel with measured target joins;
The pulse wave signal modular converter, described pulse wave signal modular converter is connected with photosignal sending and receiving module, is used for respectively two-way being carried out signal of telecommunication amplification and obtains two-way pulse wave data signal with processing;
The regional blood flow computing module, described regional blood flow computing module is connected with the pulse wave signal modular converter, is used for two-way pulse wave data signal is calculated, and obtains regional blood flow;
The physiological models creation module, described physiological models creation module is connected with standard cardiac output measurement module with the regional blood flow computing module respectively, be used for according to regional blood flow and standard cardiac output, calculate its mapping relations, and set up physiological models according to these mapping relations;
Pulse frequency value acquisition module, described pulse frequency value acquisition module is connected with the pulse wave signal modular converter, is used for the pulse frequency value that obtains from the pulse wave data signal;
The stroke volume computing module, described stroke volume computing module is connected with the physiological models creation module with the regional blood flow computing module, is used for according to regional blood flow and physiological models, calculates continuous stroke volume;
The Continuous cardiac output computing module, described Continuous cardiac output computing module is connected with pulse frequency value acquisition module with the stroke volume computing module, is used for continuous stroke volume and pulse frequency value are calculated, and obtains continuous cardiac output.
Further, a kind of kinemic continuous monitor system of the present invention also comprises:
The cardiac output display module, described cardiac output display module is connected with the Continuous cardiac output computing module, is used for continuous cardiac output is shown;
The cardiac output print module, described cardiac output print module is connected with the Continuous cardiac output computing module, is used for continuous cardiac output is printed;
The cardiac output memory module, described cardiac output memory module is connected with the Continuous cardiac output computing module, is used for continuous cardiac output is stored;
Alarm module, described alarm module is connected with the Continuous cardiac output computing module, is used for judging that Continuous cardiac output whether in preset range, if not in preset range, then carries out labelling and carries out alarm this continuous cardiac output.
Further, described photosignal sending and receiving module comprises: red signal light receiving-transmitting device and infrared signal receiving-transmitting device.
Method of the present invention is in the process of kinemic continuous monitoring, the method that the intermediate parameters of observation process is calibrated; The conduit that its utilization is connected with pressure transducer is measured the standard cardiac output among puncturing into tremulous pulse, and utilize photoelectric sensor to gather regional blood flow, and set up accurately physiological models according to the mapping relations between standard cardiac output and the regional blood flow, to realize the calibration of parameter, after calibration is finished, can remove the conduit that thrusts among the tremulous pulse, so that the present invention is more accurate to kinemic monitoring result; System of the present invention, the continuous pulse wave data signal after calibration finished is analyzed and is calculated, to realize kinemic continuous monitoring; And because the present invention does not need for a long time conduit to be stranded in the patient body, therefore reduced medical personnel's operation complexity, and reduced patient's misery and potential injury.
Description of drawings
In order to be easy to explanation, the present invention is done to describe in detail by following preferred embodiment and accompanying drawing.
Fig. 1 is the workflow diagram of the parameter calibrating method of kinemic continuous monitoring of the present invention;
The workflow diagram that Fig. 2 carries out continuous monitoring for the parameter calibrating method of using kinemic continuous monitoring of the present invention;
Fig. 3 is the structural principle sketch map of kinemic continuous monitor system of the present invention.
The specific embodiment
In order to make purpose of the present invention, technical scheme and advantage clearer, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, is not intended to limit the present invention.
See also Fig. 1, the parameter calibrating method of a kind of kinemic continuous monitoring of the present invention comprises:
Connectphotosignal 101. send out
By the blood vessel emission two-way different wave length signal of luminescent device to measured target, receive through the two ways of optical signals behind the described blood vessel, and this two ways of optical signals is converted to the corresponding signal of telecommunicationI1,I2
102. measurement standard cardiac output
When receiving through the two ways of optical signals behind the described blood vessel, the blood vessel of the conduit access measured target of pressure transducer, measurement standard cardiac output will be connected to;
103. obtain the pulse wave data signal
Respectively the signal of telecommunication is amplified with processing and obtain two-way pulse wave data signal;
104. obtain regional blood flow
Two-way pulse wave data signal is calculated, obtained the regional blood flow in the cardiac cycleQ
105. set up physiological models
Calculate the mapping relations between standard cardiac output and the regional blood flow, and set up physiological models according to these mapping relations; This arterial vascular regional blood flow of the process that the present invention relates toQCan use mapping relationsHDetermine, namely
And because regional blood flowQWith stroke volumeSVBetween exist corresponding relation, therefore, can obtainI1,I2WithSVBetween mapping relationsJ, that is:
, becauseI1WithI2The relevant information that not only contains pulse wave also includes simultaneously the information of tremulous pulse saturation, and therefore include total hemoglobin concentration and blood vessel diameter etc. information.Calibration factor in the modelμ, comprise the regional blood flow in the arteries of specific partQWith stroke volumeSVBetween percent information, comprised simultaneously arteries periodically diastole and the light path that has caused when shrinking and percent information between the arteries diameter.For different patients,μConcrete numerical value different, therefore, the factor in the different patient modelμCan obtain by the method for calibration.Therefore, by the standard cardiac outputCOWith regional blood flowQCan calculateμ, to set up accurately physiological models.
106. withdraw from the conduit that joins of blood vessel
After setting up physiological models, withdraw from the conduit that the blood vessel with measured target joins;
107. continue continuous measurement pulse wave data signal
And by the continuous blood vessel emission two-way different wave length signal to measured target of luminescent device, until obtain continuous pulse wave data signal.
See also Fig. 2, as a kind of extended mode, can utilize the parameter calibrating method of kinemic continuous monitoring of the present invention to carry out kinemic continuous monitoring, specifically comprise:
By the blood vessel emission two-way different wave length signal of luminescent device to measured target, receive through the two ways of optical signals behind the described blood vessel, and this two ways of optical signals is converted to the corresponding signal of telecommunication; Two-way different wave length signal is through the transmission of generation two-way or reflected light signal behind this blood vessel, and blood vessel in the present invention refers to the tremulous pulse of close enough human aortic, such as: carotid artery, axillary artery or femoral artery etc.The variation of vasoconstriction or expansion occurs in the impact that is not easy the factors such as temperature owing to the arteries at these positions.In the physiological models that the present invention relates to, the arteries of choosing is the closer to aorta, and the corresponding relation between its regional blood flow and the stroke volume is more stable, and measurement result is more accurate.Because the relevant parameter of physiological models is definite by calibrating, therefore the pointed specific part of the present invention can be not limited to a certain fixed position, and the operator is the State selective measurements position according to actual needs, increased the motility of operation, so that operation is more easy.
In an embodiment of the present invention, select carotid artery as the position that obtains blood oxygen pulse ripple signal.This position is nearer apart from aorta, and the diastole shrinkage degree of blood vessel is more stable.
Wherein, two-way different wave length signal comprises: red signal light and infrared signal;
202. measurement standard cardiac output
When receiving through the two ways of optical signals behind the described blood vessel, the blood vessel of the conduit access measured target of pressure transducer, measurement standard cardiac output will be connected to;
Because the individual variation of measured target, relevant parameter in the kinemic physiological models of continuous measurement is different, therefore before carrying out the continuous measurement cardiac output, need to by at least one times accurately standard cardiac output measurement result calculate relevant parameter in this physiological models;
And because the kinemic method of existing measurement is varied, so pointed measurement standard cardiac output of the present invention, can be not limited to the kinemic method of a certain particular measurement, the operator can select the proper calibration method with field condition according to actual needs, increased the motility of operation, so that operation is more easy.
In the present embodiment, can use the cardiac output of measuring through the lung-heat dilution technology of Wicresoft that physiological models is carried out the measurement standard cardiac output, it is a kind of not only simple and safe but also mode accurately.Its method is that the liquid that volume and temperature is known injects right atrium by central venous catheter.Injection carries out along with sanguimotor with after blood in the heart mixes, and temperature obtains dilution and diffusion, the change of blood heat is measured by a temperature sensor, the latter is placed on larger body circulation tremulous pulse, for example, and the far-end of a ductus arteriosus in thigh or the axillary artery.Exist corresponding relation to determine accurately cardiac output between change by the blood flow temperature and the cardiac output.The mode of this Wicresoft because it does not need conduit is inserted in patient's the heart, therefore can avoid causing the potential risks such as arrhythmia, thrombosis, angiorrhexis.
203. obtain the pulse wave data signal
Respectively the signal of telecommunication is amplified with processing and obtain two-way pulse wave data signal;
204. obtain regional blood flow
Two-way pulse wave data signal is calculated, obtained the regional blood flow in the cardiac cycleQ
205. set up physiological models
Mapping relations between calculating standard cardiac output and the regional blood flow are set up physiological models according to these mapping relations, and to this physiological models storage;
206. judge whether and again to calculate
Judge whether again to calculate mapping relations, if need again to calculate, the two ways of optical signals after then again entering the measurement standard cardiac output and receiving the described blood vessel of process;
207. renewal physiological models
If judged result is calculated again for not needing, then all stored physiological models are averaged, and upgrade physiological models according to average result;
208. withdraw from the conduit that joins of blood vessel
After setting up physiological models, withdraw from the conduit that the blood vessel with measured target joins,
209. continue continuous measurement pulse wave data signal
And by the continuous blood vessel emission two-way different wave length signal to measured target of luminescent device, until obtain continuous pulse wave data signal;
210. the pulse frequency value that obtains
The pulse frequency value that from continuous pulse wave data signal, obtainsHR,
211. obtain continuous regional blood flow
Continuous pulse wave data signal is calculated, obtained the regional blood flow of consecutive periodsQ
212. calculating stroke volume
With continuous regional blood flowQBe combined with physiological models, calculate continuous stroke volumeSV
213. calculate continuous cardiac output
Utilize continuous stroke volumeSVWith the pulse frequency valueHRCalculate, obtain continuous cardiac outputCO, namely
214. export continuous cardiac output
Obtaining continuous cardiac outputCOAfterwards, to continuous cardiac outputCOShow and/or print and/or store;
215. the cardiac output that labelling is continuous
Obtaining continuous cardiac outputCOAfterwards, judge continuous cardiac outputCOWhether in preset range, if not in preset range, then to this continuous cardiac outputCOCarry out labelling.
Please referring to Fig. 3, a kind of kinemic continuous monitor system of the present invention comprises:
Photosignal sending and receivingmodule 301, described photosignal sending and receivingmodule 301 is attached on the blood vessel of measured target, be used for by the blood vessel emission two-way different wave length signal of luminescent device to measured target, and receive through the two ways of optical signals behind the described blood vessel, this two ways of optical signals is converted to the corresponding signal of telecommunication;
Standard cardiacoutput measurement module 302, described standard cardiacoutput measurement module 302 joins with the blood vessel of measured target, comprise: interconnective standard cardiac output computer, pressure transducer, described pressure transducer gathers standard cardiac output information by conduit, calculates the standard cardiac output by the standard cardiac output computer again; And after setting up physiological models, withdraw from the conduit that the blood vessel with measured target joins;
Pulse wave signalmodular converter 303, described pulse wave signalmodular converter 303 is connected with photosignal sending and receivingmodule 301, is used for respectively two-way being carried out signal of telecommunication amplification and obtains two-way pulse wave data signal with processing;
Regional bloodflow computing module 304, described regional bloodflow computing module 304 is connected with pulse wave signalmodular converter 303, is used for two-way pulse wave data signal is calculated, and obtains regional blood flow;
Physiologicalmodels creation module 305, described physiologicalmodels creation module 305 is connected with standard cardiac output measurement module with regional bloodflow computing module 304 respectively and is connected, be used for according to regional blood flow and standard cardiac output, calculate its mapping relations, and set up physiological models according to these mapping relations;
Pulse frequencyvalue acquisition module 307, described pulse frequencyvalue acquisition module 307 is connected with pulse wave signalmodular converter 303, is used for the pulse frequency value that obtains from the pulse wave data signal;
Strokevolume computing module 308, described strokevolume computing module 308 are connected with the physiological models creation module with regional bloodflow computing module 304 and are connected, and are used for calculating continuous stroke volume according to regional blood flow and physiological models after adjusting;
Continuous cardiacoutput computing module 306, described Continuous cardiacoutput computing module 306 are connected with pulse frequency value acquisition module with strokevolume computing module 308 and are connected, and are used for continuous stroke volume and pulse frequency value are calculated, and obtain continuous cardiac output.
Further, a kind of kinemic continuous monitor system of the present invention also comprises:
The cardiac output display module, described cardiac output display module is connected with the Continuous cardiac output computing module, is used for continuous cardiac output is shown;
The cardiac output print module, described cardiac output print module is connected with the Continuous cardiac output computing module, is used for continuous cardiac output is printed;
The cardiac output memory module, described cardiac output memory module is connected with the Continuous cardiac output computing module, is used for continuous cardiac output is stored;
Alarm module, described alarm module is connected with the Continuous cardiac output computing module, is used for judging that Continuous cardiac output whether in preset range, if not in preset range, then carries out labelling and carries out alarm this continuous cardiac output.
Further, described photosignal sending and receiving module comprises: red signal light receiving-transmitting device and infrared signal receiving-transmitting device.
The above only is preferred embodiment of the present invention, not in order to limiting the present invention, all any modifications of doing within the spirit and principles in the present invention, is equal to and replaces and improvement etc., all should be included within protection scope of the present invention
Claims (9)
1. the parameter calibrating method of a cardiac output continuous monitoring is characterized in that, comprising:
By the blood vessel emission two-way different wave length signal of luminescent device to measured target, receive through the two ways of optical signals behind the described blood vessel; Simultaneously, the blood vessel of the conduit access measured target of pressure transducer, measurement standard cardiac output will be connected to;
This two ways of optical signals is converted to the corresponding signal of telecommunication, and amplifies respectively with processing and obtain two-way pulse wave data signal;
Two-way pulse wave data signal is calculated, obtained the regional blood flow of one-period;
Calculate the mapping relations between standard cardiac output and the regional blood flow, and set up physiological models according to these mapping relations;
After setting up physiological models, withdraw from the conduit that the blood vessel with measured target joins, and continue by the continuous blood vessel emission two-way different wave length signal to measured target of luminescent device, until obtain continuous pulse wave data signal.
2. the parameter calibrating method of cardiac output continuous monitoring according to claim 1 is characterized in that, the described mapping relations that calculate between standard cardiac output and the regional blood flow, and set up physiological models according to these mapping relations and also comprise:
Mapping relations between calculating standard cardiac output and the regional blood flow are set up physiological models according to these mapping relations, and to this physiological models storage;
Judge whether again to calculate mapping relations, if need again to calculate, the two ways of optical signals after then again entering the measurement standard cardiac output and receiving the described blood vessel of process; If do not need again to calculate, then all stored physiological models are averaged, and upgrade physiological models according to average result.
3. the parameter calibrating method of cardiac output continuous monitoring according to claim 2, it is characterized in that, described continuation is by the continuous blood vessel emission two-way different wave length signal to measured target of luminescent device, until obtain comprising after the continuous pulse wave data signal:
The pulse frequency value that from continuous pulse wave data signal, obtains, and to continuous pulse wave data signal calculating, obtain the regional blood flow of consecutive periods;
The regional blood flow of consecutive periods is combined with physiological models, calculates continuous stroke volume;
Utilize continuous stroke volume and pulse frequency value to calculate, obtain continuous cardiac output.
4. the parameter calibrating method of cardiac output continuous monitoring according to claim 3 is characterized in that, described obtaining comprises after the continuous cardiac output:
Continuous cardiac output is shown and/or prints and/or store.
5. the parameter calibrating method of cardiac output continuous monitoring according to claim 3 is characterized in that, described obtaining comprises after the continuous cardiac output:
Judge that continuous cardiac output whether in preset range, if not in preset range, then carries out labelling to this continuous cardiac output.
6. according to claim 4 or the parameter calibrating method of 5 described cardiac output continuous monitorings, it is characterized in that described two-way different wave length signal comprises: red signal light and infrared signal.
7. a kinemic continuous monitor system is characterized in that, comprising:
Photosignal sending and receiving module, described photosignal sending and receiving module is attached on the blood vessel of measured target, be used for by the blood vessel emission two-way different wave length signal of luminescent device to measured target, and receive through the two ways of optical signals behind the described blood vessel, this two ways of optical signals is converted to the corresponding signal of telecommunication;
Standard cardiac output measurement module, the blood vessel of described standard cardiac output measurement module and measured target joins, comprise: interconnective standard cardiac output computer, pressure transducer, described pressure transducer gathers standard cardiac output information by conduit, calculates the standard cardiac output by the standard cardiac output computer again; And after setting up physiological models, withdraw from the conduit that the blood vessel with measured target joins;
The pulse wave signal modular converter, described pulse wave signal modular converter is connected with photosignal sending and receiving module, is used for respectively two-way being carried out signal of telecommunication amplification and obtains two-way pulse wave data signal with processing;
The regional blood flow computing module, described regional blood flow computing module is connected with the pulse wave signal modular converter, is used for two-way pulse wave data signal is calculated, and obtains regional blood flow;
The physiological models creation module, described physiological models creation module is connected with standard cardiac output measurement module with the regional blood flow computing module respectively, be used for according to regional blood flow and standard cardiac output, calculate its mapping relations, and set up physiological models according to these mapping relations;
Pulse frequency value acquisition module, described pulse frequency value acquisition module is connected with the pulse wave signal modular converter, is used for the pulse frequency value that obtains from the pulse wave data signal;
The stroke volume computing module, described stroke volume computing module is connected with the physiological models creation module with the regional blood flow computing module, is used for according to regional blood flow and physiological models, calculates continuous stroke volume;
The Continuous cardiac output computing module, described Continuous cardiac output computing module is connected with pulse frequency value acquisition module with the stroke volume computing module, is used for continuous stroke volume and pulse frequency value are calculated, and obtains continuous cardiac output.
8. kinemic continuous monitor system according to claim 7 is characterized in that, also comprises:
The cardiac output display module, described cardiac output display module is connected with the Continuous cardiac output computing module, is used for continuous cardiac output is shown;
The cardiac output print module, described cardiac output print module is connected with the Continuous cardiac output computing module, is used for continuous cardiac output is printed;
The cardiac output memory module, described cardiac output memory module is connected with the Continuous cardiac output computing module, is used for continuous cardiac output is stored;
Alarm module, described alarm module is connected with the Continuous cardiac output computing module, is used for judging that Continuous cardiac output whether in preset range, if not in preset range, then carries out labelling and carries out alarm this continuous cardiac output.
9. kinemic continuous monitor system according to claim 8 is characterized in that, described photosignal sending and receiving module comprises: red signal light receiving-transmitting device and infrared signal receiving-transmitting device.
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| CN111067502A (en)* | 2018-10-19 | 2020-04-28 | 三星电子株式会社 | Apparatus and method for estimating biological information |
| CN111067502B (en)* | 2018-10-19 | 2024-05-24 | 三星电子株式会社 | Device and method for estimating biological information |
| CN116671979A (en)* | 2022-02-23 | 2023-09-01 | 深圳市理邦精密仪器股份有限公司 | Cardiac output detection method, device, electronic equipment and storage medium |
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