技术领域technical field
本发明属于医疗器械领域，涉及一种钛合金人工骨，尤其是一种钛合金人工骨/髓内钉加压固定系统的制备方法。The invention belongs to the field of medical devices, and relates to a titanium alloy artificial bone, in particular to a preparation method of a titanium alloy artificial bone/intramedullary nail pressure fixation system.
背景技术Background technique
随着现代科技的高速发展，严重高速交通肇事、劳动保护不力以及现代化武器的使用，使得四肢严重骨创伤的发生率越来越高，骨缺损，特别是大段骨缺损的治疗成为创伤骨科治疗领域的难题。对于长度小于6cm的大段骨缺损，通过传统的自体皮质松质骨或人工骨移植可基本恢复患肢的长度和功能，而对于超过6cm的大段长骨缺损的修复则较为复杂，目前应用较多的技术有自体骨移植、牵拉成骨技术和异体骨移植技术。With the rapid development of modern science and technology, serious high-speed traffic accidents, poor labor protection and the use of modern weapons, the incidence of severe bone trauma in limbs is increasing. The treatment of bone defects, especially large bone defects, has become a trauma orthopedic treatment field problems. For large bone defects with a length of less than 6 cm, the length and function of the affected limb can be basically restored by traditional autologous cortical cancellous bone or artificial bone grafting, while the repair of large long bone defects with a length of more than 6 cm is more complicated. There are many techniques including autologous bone grafting, distraction osteogenesis and allogeneic bone grafting.
自体腓骨移植：采用移植带血管蒂的自体腓骨来修复大段骨缺损是目前应用较为广泛的技术。通过将正常肢体上带血管蒂的腓骨移植到骨缺损部位，吻合的通畅血管可为腓骨继续提供营养，使的移植的腓骨与骨缺损的两断端之间以端端愈合的方式完成骨愈合过程，最终达到修复大段骨缺损的目的。自Taybr等1975年报道该技术以来，该技术及各种改良技术被广泛应用于桡骨、尺骨、胫骨和股骨的大段缺损的治疗，取得了一定效果。Autologous fibula transplantation: The use of autologous fibula with vascular pedicles to repair large bone defects is currently a widely used technique. By transplanting the fibula with vascular pedicles on the normal limb to the bone defect site, the unobstructed blood vessels can continue to provide nutrition for the fibula, so that the end-to-end healing of the transplanted fibula and the two ends of the bone defect can be completed. process, and finally achieve the purpose of repairing large bone defects. Since Taybr et al. reported this technique in 1975, this technique and various improved techniques have been widely used in the treatment of large segmental defects of the radius, ulna, tibia, and femur, and achieved certain results.
尽管自体腓骨移植取得了一定临床效果，但也存在一系列的问题。首先这是一种“拆东墙补西墙”的方法，在治疗大段骨缺损的同时却造成了其他部位新的创伤与缺损。其次，自体腓骨移植需要一定的显微外科缝合技术，影响自体腓骨成活的不确定因素较多，在移植后一旦由于各种原因造成移植的失败，不但不能达到治疗骨缺损的目的，还给患者造成不可弥补的损失。第三，由于自体腓骨移植后的再塑形过程漫长，腓骨直径较小，强度也较小，因此移植后往往有较多并发症，包括移植骨骨折(25％)和移植后一端骨不连(20％)等。这些问题，使的患者在接受自体腓骨移植方面往往心存疑虑。Although autologous fibula transplantation has achieved certain clinical effects, there are still a series of problems. First of all, this is a method of "removing the east wall to make up the west wall". While treating large bone defects, it causes new trauma and defects in other parts. Secondly, autologous fibula transplantation requires certain microsurgical suturing techniques, and there are many uncertain factors affecting the survival of autologous fibula. cause irreparable loss. Third, due to the long reshaping process after autologous fibula transplantation, the fibula has a smaller diameter and lower strength, so there are often more complications after transplantation, including bone graft fracture (25%) and nonunion of one end after transplantation (20%) etc. These problems make patients often have doubts about accepting fibular autograft.
牵拉成骨技术：牵拉成骨技术最早由Llizarov推广，指的是在特定的牵引频率和牵开率下，逐渐牵开两个有血供的骨表面，在骨表面之间有新骨形成，进而使之完全桥接两个骨面，最终经改建而形成正常结构。牵拉成骨技术的优点在于可三维方向矫正畸形、可多部位同时延长、非侵袭性治疗骨不连和骨缺损。该技术在骨缺损领域的应用诞生了“张力Distraction osteogenesis technique: The technique of distraction osteogenesis was first promoted by Llizarov, which refers to gradually retracting two bone surfaces with blood supply under a specific traction frequency and retraction rate, and there is new bone between the bone surfaces. Formed, and then completely bridged the two bone surfaces, and finally remodeled to form a normal structure. The advantages of distraction osteogenesis are that it can correct deformity in three dimensions, lengthen multiple parts at the same time, and non-invasively treat bone nonunion and bone defect. The application of this technology in the field of bone defects gave birth to the "tension"
－应力法则”理论，使人们对肢体延长的生物学过程有了新的理解。-Stress law" theory, so that people have a new understanding of the biological process of limb lengthening.
牵引成骨的并发症与延长失败的发生率随着延长长度的增加而增加。因此，Yokoyama等认为该技术应用于胫骨时需要延长的骨缺损的长度应小于胫骨总长的25％。由于牵拉过程中软组织张力很大，造成牵引过程中邻近关节主、被动活动时的剧烈疼痛与不适，毅力差的患者不敢活动，有可能造成邻近关节的僵硬(41％)，而骨不连的发生率也高达41％！另外尚有骨折端延迟愈合、肌肉挛缩、牵拉过程中造成神经血管的损伤和心理问题等。The incidence of complications of distraction osteogenesis and lengthening failure increased with the length of lengthening. Therefore, Yokoyama et al. believed that the length of the bone defect that needs to be extended when this technique is applied to the tibia should be less than 25% of the total length of the tibia. Due to the high tension of the soft tissue during the traction process, it causes severe pain and discomfort during active and passive activities of the adjacent joints during the traction process. Patients with poor perseverance dare not move, which may cause stiffness of the adjacent joints (41%). Even the incidence rate is as high as 41%! In addition, there are delayed union of fracture ends, muscle contracture, neurovascular damage and psychological problems caused by stretching.
异体骨移植：异体骨具有正常的骨强度，形态、大小与患者之间差别较小，是替代自体骨移植的良好材料。考虑到治疗骨缺损的主要目标是提高骨肿瘤患者术后的生活质量为主，所以异体骨移植目前主要应用于骨肿瘤切除后所造成的大段骨缺损，而在创伤所造成的大段骨缺损的治疗中应用较少。异体骨移植的主要并发症包括感染、关节僵硬、移植骨骨折或骨不连。感染的发生率为6～14％，常需取出异体骨，严重的甚至需要截肢。异体骨骨折的发生率高达17～42％。同时，异体骨移植后有一定免疫排斥反应，还有传播肝炎、HIV等疾病的风险。在我国，由于传统观念的束缚，遗体捐献比率很低，也造成了异体骨来源方面的限制。Allograft bone graft: Allograft bone has normal bone strength, and the shape, size and difference between patients are small, so it is a good material to replace autologous bone graft. Considering that the main goal of bone defect treatment is to improve the postoperative life quality of bone tumor patients, allogeneic bone transplantation is currently mainly used in large bone defects caused by bone tumor resection, and in large bone defects caused by trauma. It is rarely used in the treatment of defects. Major complications of bone allografting include infection, joint stiffness, and fracture or nonunion of the grafted bone. The incidence of infection is 6-14%, and the allogeneic bone often needs to be removed, and severe cases even require amputation. The incidence of allograft fractures is as high as 17-42%. At the same time, there is a certain immune rejection after allogeneic bone transplantation, and there is also the risk of spreading hepatitis, HIV and other diseases. In my country, due to the shackles of traditional concepts, the rate of body donation is very low, which also causes restrictions on the source of allogeneic bone.
组织工程技术：组织工程概念形成于20世纪80年代，其基本含义是将细胞、合成材料、处理过的天然材料和组织、细胞因子及基因治疗广泛地应用于体内地组织再生或体外地组织构建。通过将成骨细胞、成骨诱导细胞因子和支架材料有机组合，体外或体内培养出符合机体需要地不同大小的工程化骨组织，然后移植到所需要的骨缺损部位发挥其功能是骨组织工程研究的核心内容。通过近20年的研究，在所有器官的组织工程研究中，组织工程骨研究所取得的进展应该说是最令人鼓舞的。在大量动物实验研究的基础上，目前国内外均有将较小体积的工程化骨组织应用于临床并获得成功的报道，但仅限于较小体积的工程化人工骨的应用，体积较大的工程化骨的临床应用效果并不理想。研究发现，植入体内的种子细胞只有在血管周围150～200μm内才能通过营养的弥散而存活，如果不能快速建立血管，就难以构建大的有效成活的骨组织，因此，对于大段骨缺损来说，采取有效的方法解决成骨区的血管化为问题是工程化骨组织存活的关键，也是骨缺损获得治疗成功的关键。目前，工程化骨组织的血管化问题尚处于研究阶段，血管化的工程化骨组织何时能应用于临床治疗大段骨缺损尚是个未知数。Tissue engineering technology: The concept of tissue engineering was formed in the 1980s. Its basic meaning is to apply cells, synthetic materials, processed natural materials and tissues, cytokines and gene therapy to tissue regeneration in vivo or tissue construction in vitro . Through the organic combination of osteoblasts, osteogenic cytokines and scaffold materials, engineered bone tissues of different sizes that meet the needs of the body can be cultivated in vitro or in vivo, and then transplanted to the desired bone defect site to perform its function. Bone tissue engineering research core content. Through nearly 20 years of research, in the tissue engineering research of all organs, the progress made by the Institute of Tissue Engineering Bone should be said to be the most encouraging. On the basis of a large number of animal experimental studies, there are reports at home and abroad that small-volume engineered bone tissue has been applied clinically and successfully, but it is limited to the application of small-volume engineered artificial bone. The clinical application effect of engineered bone is not ideal. Studies have found that seed cells implanted in the body can survive through nutrient diffusion only within 150-200 μm around blood vessels. If blood vessels cannot be quickly established, it will be difficult to build large and effective bone tissue. Therefore, for large bone defects It is said that adopting an effective method to solve the problem of vascularization in the osteogenic area is the key to the survival of engineered bone tissue and the key to successful treatment of bone defects. At present, the vascularization of engineered bone tissue is still in the research stage, and it is still unknown when vascularized engineered bone tissue can be applied in clinical treatment of large bone defects.
无论大段骨缺损发生在上肢还是下肢，由于肢体功能的丧失，患肢由于长期的废用而多伴有较重的骨质疏松。即使采用自体腓骨移植、牵拉成骨技术或是异体骨移植技术，手术后均需要较长时间的患肢制动过程，特别对于下肢，需要较长时间的免负荷过程，造成患肢在原有废用性骨质疏松基础上的进一步恶化，使的患肢骨质量与骨强度严重下降，影响了肢体功能的康复，也增加了骨折等严重并发症发生的可能性。因此，寻找更有效的治疗大段骨缺损的方法是创伤骨科临床的迫切需要。Regardless of whether large bone defects occur in the upper or lower limbs, due to the loss of limb function, the affected limb is often accompanied by severe osteoporosis due to long-term disuse. Even if autologous fibula transplantation, distraction osteogenesis, or allograft bone grafting techniques are used, it takes a long time for the affected limb to immobilize after the operation, especially for the lower limbs, it takes a long time for the unloading process, resulting in the affected limb in the original The further deterioration on the basis of disuse osteoporosis seriously reduces the bone quality and strength of the affected limb, affects the recovery of limb function, and increases the possibility of serious complications such as fractures. Therefore, finding a more effective method for treating large bone defects is an urgent need in trauma orthopedics.
发明内容Contents of the invention
本发明的目的在于克服上述现有技术的缺点，提供一种钛合金人工骨/髓内钉加压固定系统的制备方法，其选取具有良好生物相容性、抗疲劳性和良好生物弹性模量的钛合金生物材料，采用CAD/CAM技术，以大段长骨骨缺损对侧肢体正常骨骼的信息为基础，获得重要长骨骨缺损部位的数据，在术前由计算机数控机床制作出个体化的钛合金大段骨缺损植入体，同时辅以与钛合金人工骨配套的髓内钉两端加压固定装置植入大段骨缺损区，从而达到修复骨缺损、使患者受伤肢体能尽快恢复负荷承重功能和精细动作功能，防止关节僵硬，感染等现有技术所存在的缺陷。The purpose of the present invention is to overcome the above-mentioned shortcoming of prior art, provide a kind of preparation method of titanium alloy artificial bone/intramedullary nail pressure fixation system, its selection has good biocompatibility, fatigue resistance and good bioelastic modulus Titanium alloy biomaterials, using CAD/CAM technology, based on the information of the normal bone of the opposite side of the long bone defect, to obtain the data of the important long bone defect, and before the operation, the computerized numerical control machine tool is used to produce individualized titanium alloys. Alloy large segmental bone defect implants, supplemented with titanium alloy artificial bone matching intramedullary nails at both ends of the pressurized fixation device implanted in large segmental bone defects, so as to achieve the repair of bone defects, so that the patient's injured limbs can restore the load as soon as possible The load-bearing function and fine motor function can prevent joint stiffness, infection and other defects in the existing technology.
本发明的目的是通过以下技术方案来解决的：The purpose of the present invention is solved by the following technical solutions:
这种钛合金人工骨/髓内钉加压固定系统，由钛合金人工骨段、髓内钉、加压螺帽和锁钉组成，所述钛合金人工骨段为具有空腔的圆柱体，所述髓内钉穿插于钛合金人工骨段的空腔内，髓内钉的一端设有径向锁钉孔，另一端设有加压螺纹；所述加压螺帽与加压螺纹配合安装；所述锁钉与锁钉孔配合安装。This titanium alloy artificial bone/intramedullary nail compression fixation system is composed of a titanium alloy artificial bone segment, an intramedullary nail, a compression nut and a locking nail. The titanium alloy artificial bone segment is a cylinder with a cavity. The intramedullary nail is inserted into the cavity of the titanium alloy artificial bone segment, one end of the intramedullary nail is provided with a radial locking hole, and the other end is provided with a pressurized thread; the pressurized nut is fitted with the pressurized thread ; The locking nail is installed in cooperation with the locking nail hole.
上述髓内钉的一端径向设有两个锁钉孔，该两个锁钉孔沿髓内钉轴向分布。One end of the intramedullary nail is radially provided with two locking nail holes, and the two locking nail holes are axially distributed along the intramedullary nail.
本发明还提出一种上述钛合金人工骨/髓内钉加压固定系统的制备方法，该方法为：采用CAD/CAM技术，以大段长骨骨缺损对侧肢体正常骨骼的信息为基础，获得患肢骨缺损部位的数据，由数控机床制作出钛合金人工骨段作为缺损植入体，同时制备与钛合金人工骨段配套的髓内钉以及其两端的加压螺帽和锁钉。The present invention also proposes a preparation method of the above-mentioned titanium alloy artificial bone/intramedullary nail pressurized fixation system, the method is: using CAD/CAM technology, based on the information of the normal bone of the opposite side of the long bone defect, to obtain According to the data of the bone defect of the affected limb, a titanium alloy artificial bone segment was produced by a CNC machine tool as a defect implant, and an intramedullary nail matched with the titanium alloy artificial bone segment, as well as compression nuts and locking nails at both ends were prepared.
进一步的，以上制备方法具体包括以下步骤：Further, the above preparation method specifically includes the following steps:
1)借助三维螺旋CT获取患肢对侧骨段三维数据，利用镜像反求技术获得患肢缺损部位骨段及其髓腔的三维数据；1) Obtain the 3D data of the contralateral bone segment of the affected limb with the help of 3D spiral CT, and obtain the 3D data of the bone segment and its medullary cavity at the defect site of the affected limb using mirror image inversion technology;
2)将上述数据输入数控机床，采用钛合金加工两端网状袖套式钛合金人工骨骨段及髓内钉；2) Input the above data into the CNC machine tool, and use titanium alloy to process the mesh-shaped sleeve type titanium alloy artificial bone segment and intramedullary nail at both ends;
3)依据上述髓内钉加工配套的加压螺帽和锁钉；3) According to the above-mentioned intramedullary nail processing supporting compression nut and locking nail;
4)将以上制备的人工骨骨段、髓内钉、加压螺帽和锁钉分别于符合GMP标准的车间封装，并进行环氧乙烷熏蒸灭菌。4) The artificial bone segments, intramedullary nails, pressurized nuts and locking nails prepared above are packaged in workshops conforming to GMP standards, and then sterilized by ethylene oxide fumigation.
本发明具有以下有益效果：The present invention has the following beneficial effects:
本发明钛合金人工骨/髓内钉加压固定系统的各部件经生物力学测试，生物相容性测试及大动物(山羊)股骨中段骨缺损修复实验证实，该钛合金人工骨的抗疲劳、抗压力、抗剪力及抗张力远大于新鲜成年正常人的测试数据；生物相容性良好；山羊股骨大段缺损模型修复实验证实，该人工骨植入操作简单，创伤小，伤口愈合早，植入第二日，山羊即可站立行走，三天后行走如初，无任何不良反应，影像资料表明，三周后人工骨网状袖套内可见新骨痂生成，人工骨与宿主骨接合紧密，固定牢靠，力线满意，三个月后，袖套结构内外均被新骨包绕而融合生长，疗效非常满意。Each part of the titanium alloy artificial bone/intramedullary nail pressurized fixation system of the present invention has been confirmed by biomechanical tests, biocompatibility tests and large animal (goat) middle femur bone defect repair experiments. Compression resistance, shear resistance and tension resistance are far greater than the test data of fresh adult normal people; biocompatibility is good; repair experiments on goat femoral large segmental defect models have confirmed that the artificial bone implant is easy to operate, less traumatic, and early wound healing, On the second day after the implantation, the goat could stand and walk. Three days later, the goat could walk as before without any adverse reactions. The imaging data showed that three weeks later, new callus could be seen in the artificial bone mesh sleeve, and the artificial bone was tightly bonded to the host bone. The fixation was firm and the line of force was satisfactory. After three months, the inside and outside of the cuff structure were surrounded by new bone and fused and grew, and the curative effect was very satisfactory.
附图说明Description of drawings
图1为本发明的钛合金人工骨段1结构示意图；Fig. 1 is the structural representation of titanium alloy artificial bone segment 1 of the present invention;
图2为本发明的髓内钉2和加压螺帽3结构及装配示意图；FIG. 2 is a schematic diagram of the structure and assembly of the intramedullary nail 2 and the compression nut 3 of the present invention;
图3为股骨大段骨缺损图；Figure 3 is a diagram of a large bone defect in the femur;
图4为大段人工骨段(钛合金人工骨段1)植入示意图；Fig. 4 is a schematic diagram of the implantation of a large artificial bone segment (titanium alloy artificial bone segment 1);
图5为髓内钉2植入示意图；Fig. 5 is a schematic diagram of intramedullary nail 2 implantation;
图6为安装远端锁钉示意图；Figure 6 is a schematic diagram of installing the distal locking nail;
图7为近端安装加压螺帽3使人工骨与自体骨间产生加压作用的结构状态示意图。Fig. 7 is a schematic diagram of the structural state of installing the compression nut 3 at the proximal end to generate a compression effect between the artificial bone and the autogenous bone.
其中：1为钛合金人工骨段；2为髓内钉；3为加压螺帽；4为锁钉孔；5为。Among them: 1 is a titanium alloy artificial bone segment; 2 is an intramedullary nail; 3 is a compression nut; 4 is a locking nail hole;
具体实施方式Detailed ways
下面结合附图对本发明做进一步详细描述：The present invention is described in further detail below in conjunction with accompanying drawing:
参见图1和图2，本发明的钛合金人工骨/髓内钉加压固定系统由钛合金人工骨段1、髓内钉2、加压螺帽3和锁钉5组成。其中钛合金人工骨段1为具有空腔的圆柱体，髓内钉2穿插于钛合金人工骨段的空腔内，髓内钉2的一端设有径向锁钉孔4，另一端设有加压螺纹；加压螺帽3与加压螺纹配合安装；锁钉5与锁钉孔4配合安装。Referring to FIG. 1 and FIG. 2 , the titanium alloy artificial bone/intramedullary nail compression fixation system of the present invention consists of a titanium alloy artificial bone segment 1 , an intramedullary nail 2 , a compression nut 3 and a locking nail 5 . The titanium alloy artificial bone segment 1 is a cylinder with a cavity, and the intramedullary nail 2 is inserted into the cavity of the titanium alloy artificial bone segment. One end of the intramedullary nail 2 is provided with a radial locking nail hole 4, and the other end is provided with a The pressurized thread; the pressurized nut 3 is installed in cooperation with the pressurized thread; the locking nail 5 is installed in cooperation with the locking nail hole 4.
在本发明的较佳实施例中，在髓内钉2的一端径向设有两个锁钉孔4，该两个锁钉孔4沿髓内钉2轴向分布。本发明的锁钉孔4用于将髓内钉2固定在股骨一端内，使用两个使髓内钉2在股骨内固定更稳定。In a preferred embodiment of the present invention, two locking nail holes 4 are arranged radially at one end of the intramedullary nail 2 , and the two locking nail holes 4 are axially distributed along the intramedullary nail 2 . The locking nail holes 4 of the present invention are used to fix the intramedullary nail 2 in one end of the femur, and two holes are used to make the intramedullary nail 2 more stable in the femur.
上述钛合金人工骨/髓内钉加压固定系统的制备方法如下：The preparation method of the above-mentioned titanium alloy artificial bone/intramedullary nail compression fixation system is as follows:
采用CAD/CAM技术，以大段长骨骨缺损对侧肢体正常骨骼的信息为基础，采用镜像反求技术获得患肢骨缺损部位的数据，由数控机床制作出钛合金人工骨段1作为缺损植入体，同时制备与钛合金人工骨段1配套的髓内钉2以及其两端的加压螺帽3和锁钉。该制备方法的具体步骤如下：Using CAD/CAM technology, based on the information of the normal bone of the opposite side of the large segment of long bone bone defect, the data of the bone defect of the affected limb was obtained by using mirror image reverse technology, and a titanium alloy artificial bone segment 1 was produced by a CNC machine tool as a defect implant. The intramedullary nail 2 matched with the titanium alloy artificial bone segment 1 and the compression nuts 3 and locking nails at both ends are prepared at the same time. The concrete steps of this preparation method are as follows:
1)借助三维螺旋CT获取患肢对侧骨段三维数据，利用镜像反求技术获得患肢缺损部位骨段及其髓腔的三维数据；1) Obtain the 3D data of the contralateral bone segment of the affected limb with the help of 3D spiral CT, and obtain the 3D data of the bone segment and its medullary cavity at the defect site of the affected limb using mirror image inversion technology;
2)将上述数据输入数控机床，采用钛合金加工两端网状袖套式钛合金人工骨骨段1及髓内钉2；2) Input the above data into the numerical control machine tool, and use the titanium alloy to process the titanium alloy artificial bone segment 1 and the intramedullary nail 2 with mesh sleeves at both ends;
3)依据上述髓内钉2加工配套的加压螺帽3和锁钉；3) Process the matching pressurizing nut 3 and locking nail according to the above-mentioned intramedullary nail 2;
将以上制备的人工骨骨段1、髓内钉2、加压螺帽3和锁钉分别于符合GMP标准的车间封装，并进行环氧乙烷熏蒸灭菌。The artificial bone segment 1 , the intramedullary nail 2 , the compression nut 3 and the locking nail prepared above were packaged in a GMP-compliant workshop, and sterilized by ethylene oxide fumigation.
以下详细说明本发明的钛合金人工骨/髓内钉加压固定系统的使用过程：The use process of the titanium alloy artificial bone/intramedullary nail pressurized fixation system of the present invention is described in detail below:
如图3所示为股骨大段骨缺损的情况，其中间部分严重骨创伤造成整段骨缺失，严重影响了患者的正常行走；为了使创伤的股骨能够继续发挥支撑的作用，如图4，将制备好的钛合金人工骨段1放置于段骨位置，然后使髓内钉2穿过钛合金人工骨段1并且其下端(即远端)插入股骨下部的骨节中，上端穿过股骨上部骨节，如图5所示；此时将锁钉5由股骨下部的骨节壁插入并穿过髓内钉2的锁钉孔4，将髓内钉2固定好，如图6所示，然后在股骨上部穿过骨节的髓内钉2的端头安装加压螺帽3，并旋紧加压，将整个系统固定牢固，如图7所示。As shown in Figure 3, the bone defect of the large segment of the femur, in which the severe bone trauma in the middle part caused the loss of the entire segment of bone, which seriously affected the normal walking of the patient; in order to allow the traumatized femur to continue to play a supporting role, as shown in Figure 4, The prepared titanium alloy artificial bone segment 1 is placed on the bone segment, and then the intramedullary nail 2 is passed through the titanium alloy artificial bone segment 1 and its lower end (i.e. the distal end) is inserted into the condyle of the lower part of the femur, and the upper end passes through the upper part of the femur The condyle, as shown in Figure 5; at this time, the locking nail 5 is inserted through the condyle wall of the lower part of the femur and passed through the locking nail hole 4 of the intramedullary nail 2, and the intramedullary nail 2 is fixed, as shown in Figure 6, and then A compression nut 3 is mounted on the end of the intramedullary nail 2 passing through the condyles on the upper part of the femur, and tightened and compressed to securely fix the entire system, as shown in FIG. 7 .
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210302893.6ACN102813564B (en) | 2012-08-23 | 2012-08-23 | A kind of preparation method of titanium alloy artificial bone/intramedullary nail compression fixation system |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210302893.6ACN102813564B (en) | 2012-08-23 | 2012-08-23 | A kind of preparation method of titanium alloy artificial bone/intramedullary nail compression fixation system |
| Publication Number | Publication Date |
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| CN102813564A CN102813564A (en) | 2012-12-12 |
| CN102813564Btrue CN102813564B (en) | 2015-12-09 |
| Application Number | Title | Priority Date | Filing Date |
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| CN201210302893.6AExpired - Fee RelatedCN102813564B (en) | 2012-08-23 | 2012-08-23 | A kind of preparation method of titanium alloy artificial bone/intramedullary nail compression fixation system |
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