


所属技术领域Technical field
本发明属生命科学技术领域,具体涉及一种用于对动物或人进行深部硬脑膜穿孔的装置。The invention belongs to the technical field of life sciences, and in particular relates to a device for perforating deep dura mater of animals or humans.
背景技术Background technique
动物和人在脑干等部位的表面覆盖有韧性很强的硬脑膜。深部硬脑膜穿孔是动物学在研究深部脑区(如上丘、下丘以及小脑)的功能时首先需要解决的问题。在生物学研究中,采用单位放电技术记录这些脑区活动或用微透析方法采样时,由于记录电极较细长和微透析采样探针尖端透析膜强度很低,在遇到硬脑膜阻挡时会发生弯折或损坏,因此在插入记录电极和微透析采样探针前,首先需要将硬脑膜刺穿造孔。目前是采用常规穿刺针来刺穿硬脑膜,由于插入深度难以掌握等原因,不可避免地会对硬脑膜下脑组织造成较大的损伤,导致损伤部位的细胞无法进行记录研究。In animals and humans, the surface of the brain stem and other parts is covered with a tough dura mater. Deep dural perforation is the first problem to be solved in zoology when studying the function of deep brain regions such as superior colliculus, inferior colliculus and cerebellum. In biological research, when the unit discharge technique is used to record the activity of these brain regions or the microdialysis method is used to sample, because the recording electrode is relatively slender and the strength of the dialysis membrane at the tip of the microdialysis sampling probe is very low, it will be blocked by the dura mater. Bending or damage occurs, so the dura needs to be punctured first before the recording electrode and microdialysis sampling probe can be inserted. At present, conventional puncture needles are used to puncture the dura mater. Due to the difficulty of grasping the insertion depth and other reasons, it will inevitably cause great damage to the subdural brain tissue, resulting in the inability to record and study the cells at the damaged site.
发明内容Contents of the invention
本发明的目的是克服现有技术的缺点,提供一种深部硬脑膜穿孔装置,实现既能将硬脑膜刺穿,又不会因穿孔操作对硬脑膜下脑组织造成损伤,或者能最大程度地减小穿孔操作对硬脑膜下脑组织造成的损伤。The purpose of the present invention is to overcome the shortcomings of the prior art and provide a device for deep dura mater puncture, which can not only puncture the dura mater without causing damage to the subdural brain tissue due to the perforation operation, or can maximize the Reduce the damage to subdural brain tissue caused by perforation operation.
本发明装置的结构是:The structure of device of the present invention is:
包括有一根导管,以及能插入导管内并贴着导管内壁周边滑动的如下组件:一根探针、一根穿孔针、两根或两根以上的扩孔针;Consists of a catheter, and the following components that can be inserted into the catheter and slide against the inner wall of the catheter: a probe, a piercing needle, two or more reaming needles;
探针针头端为球冠状或椭球冠状,穿孔针和各扩孔针的针头端为带刃口的三棱或四棱状;The needle end of the probe is a spherical crown or an ellipsoid crown, and the needle ends of the perforating needle and each reaming needle are triangular or quadrangular with edges;
穿孔针针头端的尖锐度和刃口长度最大,各扩孔针针头端的尖锐度和刃口长度依次减小;The sharpness and cutting edge length of the needle tip of the perforating needle are the largest, and the sharpness and cutting edge length of each reaming needle tip decrease in turn;
探针、穿孔针和各扩孔针的一端均带不能进入导管内的限位头;One end of the probe, perforating needle and each reaming needle has a limit head that cannot enter the catheter;
探针、穿孔针和各扩孔针探针不含限位头的部分均比导管长。The part of the probe, the perforator and each reaming needle probe without the stopper is longer than the catheter.
本发明装置的材质可以是制造医疗器械用的高强度不锈钢、钛合金等;限位头可以为圆柱状,棱柱状,长方体状等。The material of the device of the present invention can be high-strength stainless steel, titanium alloy, etc. used for manufacturing medical equipment; the limit head can be cylindrical, prismatic, cuboid, etc.
本发明装置优化的结构特征是:The structural feature of device optimization of the present invention is:
穿孔针和各扩孔针针头端是带刃口的三棱状。The needle ends of the perforating needle and each reaming needle are triangular with cutting edges.
探针不含限位头的部分比导管长1~1.5毫米。The part of the probe without the stopper is 1-1.5 mm longer than the catheter.
穿孔针不含限位头的部分比导管长1.1~1.5毫米,刃口长2~5毫米。The part of the perforation needle without the stopper is 1.1-1.5 mm longer than the catheter, and the cutting edge is 2-5 mm longer.
各扩孔针不含限位头的部分比导管长1.1~1.5毫米。The part of each reaming needle without the limit head is 1.1-1.5 mm longer than the catheter.
本发明装置进一步优化的结构是:扩孔针为两根,限位头为圆柱状。The further optimized structure of the device of the present invention is: there are two reaming needles, and the limit head is cylindrical.
本发明装置的工作原理:导管起引导作用,用于引导穿孔针和扩孔针插入脑内预定位置。探针尖端为钝圆形,既可用于导管插入脑内时堵塞导管,以减少对导管通过路径上的脑组织的损伤,又可用于探测脑膜的存在和位置。穿孔针尖端所带的锐利刃口最长,用于刺穿脑膜;第一根扩孔针尖端带比穿孔针刃口短一些的锐利刃口,第二根扩孔针尖端带更短一些的锐利刃口,依此类推,各扩孔针用于扩大穿孔针刺穿的脑膜孔洞。探针、穿孔针和各扩孔所带的限位头能控制插入深度。The working principle of the device of the present invention: the catheter acts as a guide for guiding the perforating needle and the reaming needle to be inserted into a predetermined position in the brain. The tip of the probe is blunt and round, which can be used to block the catheter when the catheter is inserted into the brain, so as to reduce the damage to the brain tissue along the passage of the catheter, and can also be used to detect the existence and position of the meninges. The tip of the reamer has the longest sharp edge and is used to pierce the meninges; the first reamer tip has a shorter sharp edge and the second reamer tip has a shorter The sharp edge, and so on, each reamer is used to widen the meningeal hole that the piercer pierced. Probes, piercers, and stoppers for each reamer control insertion depth.
本发明装置的使用:首先在颅骨定位点钻孔,钻通颅骨,将插有探针的导管经颅骨孔洞推进至导管前端到达硬脑膜上表面。当导管内的探针接触到硬脑膜时,探针会被硬脑膜顶起,此时用医用牙托水泥固定导管。待导管固定牢固后,将探针拔出,接着在导管内插入刃口最长的那根穿孔针,待穿孔针尖端接近硬脑膜时,用弹簧锤锤击穿孔针所带限位头的尾部,穿孔针尖端便迅速穿透硬脑膜而不发生脑组织凹陷形变。然后将该穿孔针拔出,按针头端尖锐度和刃口长度降低的顺序,依次将各扩孔针插入和拔出导管,每插入一根扩孔针就用弹簧锤锤击该扩孔针所带限位头的尾部,以逐次扩大硬脑膜孔洞。The use of the device of the present invention: first drill a hole at the positioning point of the skull, drill through the skull, push the catheter inserted with the probe through the hole in the skull to the front end of the catheter and reach the upper surface of the dura mater. When the probe in the catheter touches the dura mater, the probe will be pushed up by the dura mater, and the catheter will be fixed with medical tray cement at this time. After the catheter is firmly fixed, pull out the probe, and then insert the puncture needle with the longest cutting edge into the catheter. When the tip of the puncture needle is close to the dura mater, hit the tail of the stopper head of the puncture needle with a spring hammer , the tip of the perforating needle quickly penetrates the dura mater without depression and deformation of the brain tissue. Then pull out the perforating needle, insert and pull out the reaming needles in sequence according to the decreasing order of the sharpness of the needle end and the length of the cutting edge, and hammer the reaming needle with a spring hammer every time a reaming needle is inserted The tail of the limited head is used to gradually expand the dural hole.
本发明装置的优点:不仅可以快速穿透深部脑膜,而且对脑膜下脑组织的损伤极小,此外操作简单,体积小,重量轻。The device of the present invention has the advantages of not only being able to quickly penetrate the deep meninges, but also causing minimal damage to the brain tissue under the meninges, and being simple to operate, small in size and light in weight.
附图说明Description of drawings
图1为实施例中导管的主视剖面结构示意图。Fig. 1 is a schematic cross-sectional structural schematic diagram of the front view of the catheter in the embodiment.
图2为实施例中探针的主视结构示意图。Fig. 2 is a schematic diagram of the front view structure of the probe in the embodiment.
图3为实施例中穿孔针的主视结构示意图。Fig. 3 is a front structural schematic view of the perforating needle in the embodiment.
图4为实施例中第一扩孔针的主视结构示意图。Fig. 4 is a front structural schematic view of the first reaming needle in the embodiment.
图5为实施例中第二扩孔针的主视结构示意图。Fig. 5 is a front structural schematic view of the second reaming needle in the embodiment.
具体实施方式Detailed ways
实施例1:见图1~5。该产品用于对深度>25mm的猕猴上丘表面硬的脑膜进行穿刺,使用效果很好。Embodiment 1: see Fig. 1~5. This product is used to puncture the hard meninges on the surface of the macaque superior colliculus with a depth > 25mm, and the effect is very good.
扩孔针为两根。导管1由不锈钢制成。探针2、穿孔针3、第一扩孔针4和第二扩孔针5也由不锈钢制成,它们的针头端均为带刃口的三棱状,它们的另一端均带圆柱体状限位头。There are two reaming needles.
导管1的长度为31毫米,内径为0.59毫米。探针2不含限位头部分的长度为32.5毫米,6为其限位头。穿孔针3不含限位头部分的长度为32.5毫米,刃口长3.5毫米,7为其限位头。第一扩孔针4不含限位头部分的长度为32.2毫米,刃口长0.5毫米,8为其限位头。第二扩孔针5不含限位头部分的长度为32.2毫米,刃口长0.3毫米,9为其限位头。The
实施例2:该产品由不锈钢制成,用于对猕猴下丘表面的硬脑膜进行穿孔,使用效果很好。Example 2: This product is made of stainless steel and is used to perforate the dura mater on the surface of the inferior colliculus of macaques, and the effect is very good.
扩孔针为两根。导管、探针、穿刺针、第一扩孔针和第二扩孔针的针头端均为带刃口的三棱状,它们的另一端均带长方体状限位头。There are two reaming needles. The needle ends of the catheter, the probe, the puncture needle, the first reaming needle and the second reaming needle are all in the shape of a triangular edge, and the other ends of them are all equipped with cuboid-shaped stoppers.
导管的长度为34毫米,内径为0.59毫米。探针不含限位头部分的长度为35.5毫米,穿孔针不含限位头部分的长度为35.5毫米,刃口长3-3.5毫米。第一扩孔针不含限位头部分的长度为35.2毫米,刃口长0.5毫米。第二扩孔针不含限位头部分的长度为35.2毫米,刃口长0.3毫米。The catheter has a length of 34 mm and an inner diameter of 0.59 mm. The length of the probe without the limit head part is 35.5 mm, the length of the perforation needle without the limit head part is 35.5 mm, and the length of the cutting edge is 3-3.5 mm. The length of the first reaming needle without the limit head part is 35.2 millimeters, and the length of the cutting edge is 0.5 millimeters. The length of the second reaming needle without the limit head part is 35.2 millimeters, and the length of the cutting edge is 0.3 millimeters.
以上实施例仅仅是为了对本发明作进一步说明,而本发明的范围不受所举实施例的局限。The above examples are only for further illustrating the present invention, and the scope of the present invention is not limited by the examples given.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210102811.3ACN102631234B (en) | 2012-04-10 | 2012-04-10 | Deep cerebral dura mater perforating device |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210102811.3ACN102631234B (en) | 2012-04-10 | 2012-04-10 | Deep cerebral dura mater perforating device |
| Publication Number | Publication Date |
|---|---|
| CN102631234A CN102631234A (en) | 2012-08-15 |
| CN102631234Btrue CN102631234B (en) | 2014-01-22 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210102811.3AExpired - Fee RelatedCN102631234B (en) | 2012-04-10 | 2012-04-10 | Deep cerebral dura mater perforating device |
| Country | Link |
|---|---|
| CN (1) | CN102631234B (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103340859A (en)* | 2013-06-04 | 2013-10-09 | 中国科学院昆明动物研究所 | Method for establishing non-human primate animal model of Parkinson's disease by administration of MPP+ in lateral ventricle |
| CN103284980A (en)* | 2013-06-18 | 2013-09-11 | 中国科学院昆明动物研究所 | Method for establishing animal model for senile dementia, special liquid medicine and dosing device |
| CN115721390A (en)* | 2014-06-07 | 2023-03-03 | 王苏 | A method of using a puncture device for closed chest drainage |
| CN104783919A (en)* | 2015-04-29 | 2015-07-22 | 桂林医学院 | Brain tissue damage experimental facility |
| CN110064104A (en)* | 2018-01-22 | 2019-07-30 | 南京农业大学 | A kind of surface has the medical use needle and preparation method thereof of micro-nano composite antibacterial texture |
| CN108926384A (en)* | 2018-07-06 | 2018-12-04 | 北京柏惠维康科技有限公司 | Meninx needle and meninx hole-drilling system |
| CN114469280A (en)* | 2022-01-24 | 2022-05-13 | 上海精劢医疗科技有限公司 | Sensing positioning needle |
| CN119411205B (en)* | 2025-01-02 | 2025-06-10 | 临港国家实验室 | Needle preparation method and needle |
| CN119837612A (en)* | 2025-03-19 | 2025-04-18 | 中国科学院脑科学与智能技术卓越创新中心 | Implant assembly and corresponding implant device |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4721506A (en)* | 1986-11-07 | 1988-01-26 | Teves Leonides Y | Flat-inclined tip needle |
| EP0401525A1 (en)* | 1989-06-06 | 1990-12-12 | B. Braun Melsungen AG | Set of instruments with a catheter for continuous spinal anaesthesia |
| CN2284600Y (en)* | 1996-12-02 | 1998-06-24 | 昌乐县人民医院 | Safety cranial trepan |
| CN1767867A (en)* | 2003-04-08 | 2006-05-03 | 特殊健康产品公司 | Safety shield for medical needles |
| CN101267774A (en)* | 2005-09-23 | 2008-09-17 | 霍格兰德·托马斯 | Surgical drill, surgical drill set, system for cutting bone and method for removing bone |
| CN101316553A (en)* | 2005-10-06 | 2008-12-03 | 简斯·斯科恩博格 | Electrode bundle |
| CN101415375A (en)* | 2006-04-04 | 2009-04-22 | 安常勋 | Reamer for operating implant |
| CN201453366U (en)* | 2009-06-01 | 2010-05-12 | 顾晓晖 | Flexible vertebral pedicle prospecting drill |
| CN201453728U (en)* | 2009-04-17 | 2010-05-12 | 陈创 | Mobile dual-use skull-drilling drainage device |
| CN201930380U (en)* | 2010-12-10 | 2011-08-17 | 谷卫民 | Skull puncture drainage nail |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86200383U (en)* | 1986-01-23 | 1986-12-24 | 江砥宸 | Combined hole-drilling and dilatating drill for opening skull |
| CN2542212Y (en)* | 2002-05-13 | 2003-04-02 | 邵庚年 | Neurosurgery posterior cranial fossa cranial bone cutter |
| CN2855427Y (en)* | 2005-03-03 | 2007-01-10 | 徐屹 | Needle tubing for intracranial puncture and drainage |
| KR20080061707A (en)* | 2006-12-28 | 2008-07-03 | 김경태 | A hypodermic syringe |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4721506A (en)* | 1986-11-07 | 1988-01-26 | Teves Leonides Y | Flat-inclined tip needle |
| EP0401525A1 (en)* | 1989-06-06 | 1990-12-12 | B. Braun Melsungen AG | Set of instruments with a catheter for continuous spinal anaesthesia |
| CN2284600Y (en)* | 1996-12-02 | 1998-06-24 | 昌乐县人民医院 | Safety cranial trepan |
| CN1767867A (en)* | 2003-04-08 | 2006-05-03 | 特殊健康产品公司 | Safety shield for medical needles |
| CN101267774A (en)* | 2005-09-23 | 2008-09-17 | 霍格兰德·托马斯 | Surgical drill, surgical drill set, system for cutting bone and method for removing bone |
| CN101316553A (en)* | 2005-10-06 | 2008-12-03 | 简斯·斯科恩博格 | Electrode bundle |
| CN101415375A (en)* | 2006-04-04 | 2009-04-22 | 安常勋 | Reamer for operating implant |
| CN201453728U (en)* | 2009-04-17 | 2010-05-12 | 陈创 | Mobile dual-use skull-drilling drainage device |
| CN201453366U (en)* | 2009-06-01 | 2010-05-12 | 顾晓晖 | Flexible vertebral pedicle prospecting drill |
| CN201930380U (en)* | 2010-12-10 | 2011-08-17 | 谷卫民 | Skull puncture drainage nail |
| Publication number | Publication date |
|---|---|
| CN102631234A (en) | 2012-08-15 |
| Publication | Publication Date | Title |
|---|---|---|
| CN102631234B (en) | Deep cerebral dura mater perforating device | |
| CN102652682B (en) | Micro brain-tissue sampler | |
| JP5683867B2 (en) | Treatment tool | |
| JP2007526065A5 (en) | ||
| CN206792427U (en) | Tumor sampler | |
| US9668718B2 (en) | Methods and apparatus for tissue removal | |
| CN201042556Y (en) | A deep vein puncture device | |
| CN104720874A (en) | Ejection type bone puncture biopsy surgical instrument assembly | |
| CN106388872A (en) | Living tissue puncturing and sampling needle | |
| CN207152608U (en) | A kind of biological tissue punctures sampling probe | |
| CN203400185U (en) | Hair planting tool | |
| JP2016077445A (en) | Bone biopsy tool and bone tissue collection method | |
| CN206342532U (en) | Novel ultrasonic guiding shifts thyroid needle device with anti-needle track | |
| CN203647390U (en) | Puncture needle for multi-point biopsy under guidance of type B ultrasonography | |
| CN100512895C (en) | Deep vein puncture device | |
| CN204133498U (en) | Tumor biopsy sampler | |
| CN212281441U (en) | Biopsy needle | |
| CN204260798U (en) | A kind of bone tumor biopsy needle | |
| EA034491B1 (en) | Syringe and relative needle | |
| CN217960160U (en) | Tissue puncture sampling needle and sampling device containing same | |
| CN211022797U (en) | Integrated puncture biopsy needle | |
| CN206138552U (en) | Vascular intubate system under scope | |
| EP3000402B1 (en) | Puncture treatment instrument for endoscope | |
| CN203776884U (en) | Novel artery remaining needle | |
| CN219461228U (en) | Puncture biopsy needle |
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right | Owner name:ZHEJIANG UNIVERSITY Effective date:20150427 | |
| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information | Inventor after:Lei Xiaoguang Inventor after:Yang Shangchuan Inventor after:Wu Jing Inventor after:Wang Wenchao Inventor after:Hu Yingzhou Inventor after:Ma Yuanye Inventor after:Hu Xintian Inventor after:Zhang Baorong Inventor before:Yang Shangchuan Inventor before:Wu Jing Inventor before:Hu Yingzhou Inventor before:Ma Yuanye Inventor before:Hu Xintian | |
| COR | Change of bibliographic data | Free format text:CORRECT: INVENTOR; FROM: YANG SHANGCHUAN WU JING HU YINGZHOU MA YUANYE HU XINTIAN TO: LEI XIAOGUANGYANG SHANGCHUAN WU JING WANG WENCHAO HU YINGZHOU MA YUANYE HU XINTIAN ZHANG BAORONG | |
| TR01 | Transfer of patent right | Effective date of registration:20150427 Address after:650000 No. 32 East Road, Kunming, Yunnan Patentee after:Kuiming Animal Institute of Chinese Academy of Sciences Patentee after:Zhejiang University Address before:650000 No. 32 East Road, Kunming, Yunnan Patentee before:Kuiming Animal Institute of Chinese Academy of Sciences | |
| CF01 | Termination of patent right due to non-payment of annual fee | Granted publication date:20140122 Termination date:20150410 | |
| EXPY | Termination of patent right or utility model |