技术领域technical field
本发明涉及一种检测试片，尤指一种具有采集导引功能的检测试片，以运用于一兼具采样及检测功能的检测装置。The invention relates to a detection test piece, in particular to a detection test piece with the function of collecting and guiding, so as to be used in a detection device with the functions of sampling and detection.
背景技术Background technique
随着生物检测技术的发展，原本需要到特定场所(如医院、检验室或实验室)，并藉助精密仪器及医疗专业人才(如医师、检验师或研究员)才能检测的检验项目，如今病人已能在家进行不需专业人员的居家检测。With the development of biological detection technology, the test items that originally needed to go to a specific place (such as a hospital, laboratory or laboratory) and rely on precision instruments and medical professionals (such as physicians, examiners or researchers) to detect test items, now patients have Home testing can be performed at home without the need for professionals.
举例来说，许多糖尿病患者每天都需要监视其血液的血糖含量。目前已经有数种系统可供民众方便监视其血液的血糖含量。此种系统通常包括一让使用者采集血液样本的检测试片；以及一用以读取该检测试片以决定该血液的血糖含量的测量计。For example, many diabetics need to monitor their blood sugar levels on a daily basis. There are several systems that allow the public to easily monitor the blood sugar levels in their blood. Such systems generally include a test strip for the user to collect a blood sample; and a meter for reading the test strip to determine the blood glucose level.
现在普遍使用电化学技术于测量血液的血糖含量，此技术通常于该检测试片上提供含有特定酵素试剂(例如葡萄糖氧化酵素及介质)的一反应区。当使用者将血液样本吸取于该反应区时，该测量计则会施加一电压至该检测试片，该特定酵素试剂便会与血液样本中的血糖产生电化学反应，该测量计测量所生成的电流，并且依照该电流来计算血糖含量。Electrochemical techniques are commonly used to measure blood glucose levels, and this technique usually provides a reaction zone containing specific enzyme reagents (such as glucose oxidase and mediator) on the test strip. When the user draws the blood sample in the reaction area, the measuring meter will apply a voltage to the test strip, and the specific enzyme reagent will electrochemically react with the blood glucose in the blood sample, and the measuring meter will measure the generated current, and according to the current to calculate the blood sugar level.
而采集血液样本与检测血液样本分别利用不同的装置进行，采集血液样本为一检测试片搭配一附有采血针的采血装置进行采集；检测血液样本则透过上述测量计进行检测。使用者必须先使用采血装置刺破受测部位，并挤压受测部位，再将血液吸取至该检测试片的该反应区，然后将该检测试片插入该测量计进行检测，由于采血装置通常会重复使用，如此一来该采血装置与使用者的接触位置就很容易发生血液感染的问题，进而造成使用者间的交互感染。The collection of blood samples and the detection of blood samples are carried out by different devices. The collection of blood samples is a test strip and a blood collection device with a blood collection needle for collection; the detection of blood samples is carried out through the above-mentioned measuring meter. The user must first use the blood collection device to puncture the part to be tested, and squeeze the part to be tested, then draw blood to the reaction area of the test strip, and then insert the test strip into the measuring meter for testing. Usually, it will be used repeatedly, so the problem of blood infection is easy to occur at the contact position between the blood collection device and the user, and then causes cross-infection among users.
目前已有结合该采血装置及该测量计的检测装置，但该等检测装置的结构过于复杂，难以操作，而且维修困难，举例来说，美国专利第6506168号提供了一种结合该采血装置及该测量计的检测装置，由其图4可知，该专利所揭露的检测试片于采样时需进行移动，以确保取得血液，因此需额外的推进装置；另外，为了提升采集血液的能力，还需要提供一真空环境，使得整个该检测装置的结构较为复杂，且易于故障，显非理想的设计。At present, there are detection devices combining the blood collection device and the measuring meter, but the structures of these detection devices are too complicated, difficult to operate, and difficult to maintain. For example, U.S. Patent No. 6,506,168 provides a combination of the blood collection device and As can be seen from Figure 4 of the detection device of the meter, the detection test piece disclosed in this patent needs to be moved during sampling to ensure that blood is obtained, so an additional propulsion device is required; in addition, in order to improve the ability of collecting blood, there is also A vacuum environment needs to be provided, which makes the structure of the whole detection device more complex and prone to failure, which is not an ideal design.
为了解决上述问题，本发明提供一种检测试片，易于检体的采集，且运用于一兼具采样及检测功能的检测装置时，该检测装置不需要太过复杂的装置，且可以避免交互感染的问题。In order to solve the above problems, the present invention provides a detection test piece, which is easy to collect samples, and when applied to a detection device with both sampling and detection functions, the detection device does not need too complicated devices, and can avoid interaction Infection problem.
发明内容Contents of the invention
本发明的目的，在于提供一种检测试片，该检测试片是利用电化学反应检测，其于一采样穿孔的周围设置至少一内采样区，可采集并导引检体进入至少一反应区产生电化学反应。The purpose of the present invention is to provide a detection test piece, which is detected by electrochemical reaction, and at least one inner sampling area is set around a sampling perforation, which can collect and guide the sample into at least one reaction area produce an electrochemical reaction.
本发明的目的，在于提供一种检测试片，其于一采样穿孔的周围设置至少一抵压凸出件，可抵压一待测者的一受测部位，以加速检体从受测部位渗出而进入至少一反应区产生电化学反应，运用于一兼具采样及检测功能的检测装置，能达到避免检测上交互感染的问题。The purpose of the present invention is to provide a detection test piece, which is provided with at least one pressing protrusion around a sampling perforation, which can press a tested part of a subject to accelerate the sample from the tested part. Seep out and enter at least one reaction zone to generate electrochemical reaction, and apply it to a detection device with both sampling and detection functions, so as to avoid the problem of cross-infection in detection.
本发明的技术方案：一种检测试片，是包含：Technical scheme of the present invention: a kind of detection test piece, is to comprise:
一检测区，该检测区是具有：A detection zone, the detection zone has:
一采样穿孔；a sampling perforation;
至少一该采样通道，是对应该采样穿孔；At least one sampling channel corresponds to the sampling hole;
至少一反应区，位于该采样通道内；以及at least one reaction zone located within the sampling channel; and
一内采样区，位于该采样穿孔的周围，该内采样区的端边是设有一内采样缺口，连通该采样穿孔与该采样通道；以及An inner sampling area is located around the sampling hole, and the end of the inner sampling area is provided with an inner sampling gap to communicate with the sampling hole and the sampling channel; and
一电路系统，其电性连接该反应区。A circuit system is electrically connected to the reaction area.
本发明中，更包含：In the present invention, further include:
一基板，该基板具有一基板穿孔；a substrate having a through-substrate hole;
一间隔层，覆盖于该基板，该间隔层具有一通道间隔，该通道间隔是对应该基板穿孔；以及a spacer layer covering the substrate, the spacer layer has a channel spacer, and the channel spacer is corresponding to the through hole of the substrate; and
一上盖片，覆盖于该间隔层，该上盖片具有一上盖穿孔；a cover sheet covering the spacer layer, the cover sheet has a cover perforation;
其中该基板穿孔、该通道间隔与该上盖穿孔的重复孔位是形成该采样穿孔；该通道间隔与该基板、该上盖片间是形成该采样通道。The repeated holes of the substrate through hole, the channel space and the upper cover perforation form the sampling through hole; the channel space, the substrate and the upper cover sheet form the sampling channel.
本发明中，其中该内采样区为至少一内采样凸部，位于该采样穿孔与该采样通道之间，该内采样凸部是从该采样通道对应该采样穿孔的端边向该采样穿孔延伸凸出，该内采样凸部为该基板上的一基板内凸部或/及该上盖片上的一上盖内凸部所形成。In the present invention, the inner sampling area is at least one inner sampling convex part, located between the sampling through hole and the sampling channel, and the inner sampling convex part extends from the end edge of the sampling channel corresponding to the sampling perforation to the sampling perforation The inner sampling protrusion is formed by an inner protrusion of the substrate on the substrate or/and an inner protrusion of the upper cover on the upper cover.
本发明中，其中该内采样凸部的前端是与该采样穿孔的中心距离为0.2mm～2mm。In the present invention, the distance between the front end of the inner sampling convex part and the center of the sampling perforation is 0.2mm-2mm.
本发明中，其中该上盖穿孔是与该基板穿孔为大小不同的孔位，该上盖穿孔与该基板穿孔间的区域是形成一内采样区。In the present invention, wherein the through hole of the upper cover is a hole with a different size from the through hole of the substrate, and the area between the through hole of the upper cover and the through hole of the substrate forms an inner sampling area.
本发明中，其中该采样穿孔的孔距为0.4mm～4mm。In the present invention, the hole distance of the sampling perforations is 0.4mm-4mm.
本发明中，其中该内采样区更包含有至少一内采样凸部，位于该采样穿孔与该采样通道之间，该内采样凸部是从该采样通道对应该采样穿孔的端边向该采样穿孔延伸凸出，该内采样凸部为该基板上的一基板内凸部或该上盖片上的一上盖内凸部所形成。In the present invention, the inner sampling region further includes at least one inner sampling convex portion located between the sampling perforation and the sampling channel, and the inner sampling convex portion is from the end edge of the sampling channel corresponding to the sampling perforation to the sampling channel. The perforation extends and protrudes, and the inner sampling protrusion is formed by an inner protrusion of the substrate on the substrate or an inner protrusion of the upper cover on the upper cover.
本发明中，该采样穿孔的周围是设有至少一抵压凸出件。In the present invention, at least one pressing protrusion is arranged around the sampling hole.
本发明中，更包含至少一定位件，其中该定位件为一穿孔、一切口或一凸块。In the present invention, at least one positioning element is further included, wherein the positioning element is a perforation, a notch or a protrusion.
本发明中，其进一步包含至少一外采样区，该外采样区是位于该检测试片的外侧，该外采样区是连通于该采样通道。In the present invention, it further includes at least one outer sampling area, the outer sampling area is located on the outside of the test strip, and the outer sampling area is connected to the sampling channel.
本发明还同时公开了一种检测试片，是包含：The present invention also discloses a detection test piece at the same time, which comprises:
一检测区，该检测区是具有：A detection zone, the detection zone has:
一采样穿孔；a sampling perforation;
至少一采样通道，是对应该采样穿孔；At least one sampling channel corresponds to the sampling perforation;
至少一反应区，位于该采样通道内；以及at least one reaction zone located within the sampling channel; and
至少一抵压凸出件，设于该采样穿孔的周围；以及At least one pressing protruding piece is arranged around the sampling hole; and
一电路系统，其电性连接该反应区。A circuit system is electrically connected to the reaction area.
本发明中，更包含：In the present invention, further include:
一基板，具有一基板穿孔；A substrate having a through-substrate hole;
一间隔层，覆盖于该基板，该间隔层具有一通道间隔，该通道间隔是对应该基板穿孔；以及a spacer layer covering the substrate, the spacer layer has a channel spacer, and the channel spacer is corresponding to the through hole of the substrate; and
一上盖片，覆盖于该间隔层，该上盖片具有一上盖穿孔；a cover sheet covering the spacer layer, the cover sheet has a cover perforation;
其中该基板穿孔、该通道间隔与该上盖穿孔的重复孔位是形成该采样穿孔，该通道间隔与该基板、该上盖片间是形成该采样通道。The repeated holes of the substrate through hole, the channel space and the upper cover perforation form the sampling through hole, and the channel space, the substrate and the upper cover sheet form the sampling channel.
本发明中，其中该抵压凸出件是设于该基板穿孔、该通道间隔或该上盖穿孔的周围。In the present invention, the pressing protruding part is arranged around the through hole of the substrate, the channel space or the through hole of the upper cover.
本发明中，其中该采样穿孔的孔距为0.4mm～4mm。In the present invention, the hole distance of the sampling perforations is 0.4mm-4mm.
本发明中，其中该抵压凸出件的高度为0.01mm～2mm。In the present invention, the height of the pressing protrusion is 0.01mm-2mm.
本发明中，其中该采样通道与该采样穿孔之间是设有至少一内采样凸部，该内采样凸部是从该采样通道对应该采样穿孔的端边向该采样穿孔延伸凸出，该内采样凸部的端边是设有一内采样缺口，该内采样凸部为该基板上的一基板内凸部或/及该上盖片上的一上盖内凸部所形成。In the present invention, at least one inner sampling protrusion is provided between the sampling channel and the sampling hole, and the inner sampling protrusion extends and protrudes from the end edge of the sampling channel corresponding to the sampling hole to the sampling hole. An inner sampling notch is provided on the edge of the inner sampling protrusion, and the inner sampling protrusion is formed by an inner protrusion of the substrate on the substrate or/and an inner protrusion of the upper cover on the upper cover.
本发明中，其中该内采样凸部的前端是与该采样穿孔的中心距离为0.2mm～2mm。In the present invention, the distance between the front end of the inner sampling convex part and the center of the sampling perforation is 0.2mm-2mm.
本发明中，更包含至少一定位件，该定位件为一穿孔、一切口或一凸块。In the present invention, at least one positioning element is further included, and the positioning element is a perforation, a cutout or a protrusion.
本发明中，其进一步包含有至少一外采样区，该外采样区是位于该检测试片的外侧，该外采样区是连通于该采样通道。In the present invention, it further includes at least one outer sampling area, the outer sampling area is located on the outside of the test strip, and the outer sampling area is connected to the sampling channel.
本发明具有的有益效果：该检测试片易于检体的采集及便于配合一兼具采样及检测功能的检测装置而能避免检测上的交互感染。The invention has beneficial effects: the detection test piece is easy to collect specimens and is convenient to cooperate with a detection device with both sampling and detection functions, so as to avoid cross-infection in detection.
附图说明Description of drawings
图1：本发明的第一实施例的检测试片的立体图；Fig. 1: the perspective view of the detection test piece of the first embodiment of the present invention;
图2：本发明沿图1AA’剖线的剖面图；Fig. 2: the sectional view of the present invention along Fig. 1 AA ' section line;
图3：本发明采样穿孔的各式态样结构示意图；Figure 3: Structural schematic diagram of various patterns of sampling perforation in the present invention;
图4：本发明采样穿孔的放大示意图；Fig. 4: enlarged schematic diagram of the sampling perforation of the present invention;
图5：本发明第一实施例的分解图；Fig. 5: exploded view of the first embodiment of the present invention;
图6、图6A：本发明的试片各层变化例示意图(一)；Fig. 6, Fig. 6A: the schematic diagram (1) of each layer variation example of the test piece of the present invention;
图7、图7A：本发明的试片各层变化例示意图(二)；Fig. 7, Fig. 7A: the schematic diagram (two) of each layer variation example of the test piece of the present invention;
图8、图8A：本发明的试片各层变化例示意图(三)；Fig. 8, Fig. 8A: Schematic diagram (three) of each layer variation example of the test piece of the present invention;
图9、图9A：本发明的试片各层变化例示意图(四)；Fig. 9, Fig. 9A: schematic diagram (four) of each layer variation example of test piece of the present invention;
图10、图10A：本发明的试片各层变化例示意图(五)；Fig. 10, Fig. 10A: Schematic diagram (five) of each layer variation example of test piece of the present invention;
图11、图11A：本发明的试片各层变化例示意图(六)；Fig. 11, Fig. 11A: the schematic diagram of each layer variation example of the test piece of the present invention (six);
图12：本发明的试片使用示意图；Figure 12: Schematic diagram of the use of the test piece of the present invention;
图13：本发明的使用状态局部剖视示意图；Figure 13: a partial cross-sectional schematic diagram of the use state of the present invention;
图14：本发明的使用状态局部剖视上视示意图；Fig. 14: a partial cross-sectional top view schematic diagram of the use state of the present invention;
图15：本发明变化例的检测试片的立体图；Figure 15: a perspective view of a detection test piece of a modification example of the present invention;
图16：本发明变化例的使用状态局部剖视示意图；Fig. 16: a partial cross-sectional schematic view of the use state of the variation of the present invention;
图17：本发明变化例的使用状态局部剖视上视示意图；Fig. 17: a schematic diagram of a partially sectioned top view of a modified example of the present invention in use;
图18：本发明另一变化例的使用状态剖视示意图。Fig. 18: A schematic cross-sectional view of another variation of the present invention in use.
【图号简单说明】[Simple description of figure number]
1检测试片 111电路连接部1 Detection test piece 111 circuit connection part
2检测装置 112检测电极2 detection device 112 detection electrodes
3受测部位 113导线3 tested parts 113 wires
4检体 121基板穿孔4 specimens 121 substrate perforations
10检测区 122基板内凸部10 detection area 122 inner convex part of substrate
11电路系统 123基板外凸部11 Circuit system 123 Substrate convex part
12基板 124基板定位件12 Base Board 124 Base Board Positioning Parts
13间隔层 131通道间隔13 bay layers 131 channel bays
14上盖片 132隔层定位件14 Top cover 132 Compartment positioning piece
21采样模块 141上盖穿孔21 Sampling module 141 Cover perforation
22检测模块 142上盖内凸部22 Detection module 142 Inner convex part of upper cover
23采血针 143上盖外凸部23 blood collection needle 143 convex part of upper cover
101采样穿孔 144上盖定位件101 sampling perforation 144 upper cover positioning piece
102内采样区 211采样部102 Inner Sampling Area 211 Sampling Department
102A内采样凸部 211A采样开口102A internal sampling convex part 211A sampling opening
102B内采样缺口 211B采样抵压凸件102B inner sampling gap 211B sampling pressure convex piece
103外采样区 211C抵压缺口103 outer sampling area 211C pressure gap
103A外采样凸部 211D试片定位件103A External sampling convex part 211D Test piece positioning part
103B外采样缺口 212杆部103B outer sampling notch 212 stem
104反应区 221试片插槽104 reaction area 221 test piece slot
105采样通道 222电性连接器105 sampling channels 222 electrical connectors
106定位件 A圆形穿孔106 positioning piece A round perforation
107握持部 C穿孔中心107 grip part C perforation center
108抵压凸出件108 pressure protruding parts
具体实施方式Detailed ways
为使对本发明的结构特征及所达成的功效有更进一步的了解与认识，用以较佳的实施例及附图配合详细的说明，说明如下：In order to have a further understanding and understanding of the structural features of the present invention and the achieved effects, the preferred embodiments and accompanying drawings are used for a detailed description, as follows:
请参阅图1及图2，是本发明的第一实施例的检测试片的立体图及AA’方向剖面图。如图所示，本实施例提供一种检测试片1，本实施例的检测试片1是利用电化学感测方式进行检测。检测试片1具有一检测区10及一电路系统11，检测区10主要是用来采集一检体4(例如血液)并进行其检测，所以于该检测区10具有一采样穿孔101、二反应区104及二采样通道105，采样穿孔101为一贯穿孔，供一采血针23穿过并采集一待测者的血液检体4。二反应区104位于采样通道105内。该采样穿孔101的周围设有一内采样区102，该内采样区102包括有一内采样凸部102A，该内采样凸部102A是从采样通道105的端边凸伸临近该采样穿孔101的中心部位，内采样凸部102A相对采样穿孔101的端壁具有一内采样缺口102B，该内采样缺口102B是连通该采样通道105，使该采样通道105的通道得以延伸接近该采样穿孔101的中心部位，以便利采血，换言之，内采样凸部102A是位于该采样穿孔101与该采样通道105之间，且该内采样缺口102B及反应区104是透过采样通道105连接，采样穿孔101所采集的检体4从内采样缺口102B进入，并透过采样通道105传送至二反应区104，检体4于反应区104内进行电化学反应，以产生两组检测讯号。Please refer to FIG. 1 and FIG. 2 , which are perspective views and AA' sectional views of the detection test piece according to the first embodiment of the present invention. As shown in the figure, this embodiment provides a detection test piece 1 , and the detection test piece 1 of this embodiment is detected by means of electrochemical sensing. The detection test strip 1 has a detection area 10 and a circuit system 11. The detection area 10 is mainly used to collect a sample 4 (such as blood) and perform its detection, so the detection area 10 has a sampling perforation 101, two reaction In the area 104 and the two sampling channels 105, the sampling hole 101 is a through hole for a blood collection needle 23 to pass through and collect a blood sample 4 of a subject. The second reaction zone 104 is located in the sampling channel 105 . An inner sampling area 102 is arranged around the sampling hole 101, and the inner sampling area 102 includes an inner sampling convex portion 102A, which protrudes from the end edge of the sampling channel 105 and is close to the center of the sampling hole 101 The inner sampling convex part 102A has an inner sampling notch 102B relative to the end wall of the sampling perforation 101, and the inner sampling notch 102B is connected to the sampling channel 105, so that the channel of the sampling channel 105 can be extended close to the central part of the sampling perforation 101, To facilitate blood collection, in other words, the inner sampling convex portion 102A is located between the sampling perforation 101 and the sampling channel 105, and the inner sampling notch 102B and the reaction area 104 are connected through the sampling channel 105, and the sample collected by the sampling perforation 101 The sample 4 enters through the inner sampling gap 102B, and is sent to the second reaction area 104 through the sampling channel 105. The sample 4 undergoes an electrochemical reaction in the reaction area 104 to generate two sets of detection signals.
请参阅图3，该采样穿孔101是可为图示的各种构成态样，又如图4所示，该内采样凸部102A的构成类似检测试片1本身为一圆形穿孔A(或其它形状如多边形、椭圆形等，此以圆孔为例作说明)侧边凸伸入，而形成位于该圆形穿孔A范围内的该内采样凸部102A，该圆形穿孔A所剩穿孔部份即为该采样穿孔101；而该内采样凸部102A的内采样缺口102B与采样穿孔101的中心部位仅距X距离，较该圆形穿孔A的边界更邻近采样穿孔101的中心部位C(半径Y)，即该内采样凸部102A前端的内采样缺口102B是与采样穿孔101的其它部位(非处于该内采样凸部102A上)较邻近该穿孔中心C，如此藉该内采样缺口102B使吸取导引血液的效果更佳，而该X的较佳距离为0.2mm～2mm。Please refer to Fig. 3, the sampling perforation 101 can be various configurations as shown in the figure, and as shown in Fig. Other shapes such as polygon, ellipse, etc. (this takes a circular hole as an example) protrude from the side to form the inner sampling convex part 102A within the range of the circular perforation A, and the remaining perforations of the circular perforation A Part is the sampling perforation 101; and the inner sampling notch 102B of the inner sampling convex portion 102A is only at a distance X from the center of the sampling perforation 101, which is closer to the center C of the sampling perforation 101 than the boundary of the circular perforation A (radius Y), that is, the inner sampling notch 102B at the front end of the inner sampling convex portion 102A is closer to the center C of the perforation with other parts of the sampling perforation 101 (not on the inner sampling convex portion 102A), so that the inner sampling notch 102B makes the effect of sucking and guiding blood better, and the preferred distance of this X is 0.2mm-2mm.
其它实施方式中，该检测试片1于该检测区10的外侧是进一步设有一外采样区103，该外采样区103包括有一外采样凸部103A，外采样凸部103A的侧壁是设有一连通该采样通道105的外采样缺口103B，该外采样凸部103A是作为另种采集方式，可使血液经该外采样缺口103B、采样通道105而至该反应区104，具有单独采集检测的效果。另，该检测试片1于该样穿孔101的周围适当位置是设有至少一定位件106，该定位件106是可为一穿孔、切口或一凸块，用以配合对应使用的检测装置2，以达到该检测试片1的定位。In other embodiments, the detection test strip 1 is further provided with an outer sampling area 103 outside the detection area 10, the outer sampling area 103 includes an outer sampling convex portion 103A, and the side wall of the outer sampling convex portion 103A is provided with a Connected to the outer sampling notch 103B of the sampling channel 105, the outer sampling convex portion 103A is used as another collection method, allowing blood to pass through the outer sampling notch 103B and the sampling channel 105 to the reaction zone 104, which has the effect of separate collection and detection . In addition, the detection test piece 1 is provided with at least one positioning piece 106 at an appropriate position around the perforation 101. The positioning piece 106 can be a perforation, a cutout or a bump, and is used to cooperate with the corresponding detection device 2. , to achieve the positioning of the detection test piece 1.
该电路系统11是具有二组电路连接部111及二组检测电极112，该电路连接部111位于该检测试片1相对该检测区10的另一端，并连接该检测电极112，用与一检测装置2电性组接，以传输检测讯号至检测装置2进行分析。该检测电极112是设于该反应区104，使反应区104藉由该检测电极112传送检测讯号至检测装置2，该组检测电极112至少具有一工作电极及一参考电极，该检测电极112是以导线113连接该电路连接部111。上述内采样缺口102B、反应区104、采样通道105及检测电极112的数量为二个(或组)，仅为本发明的一较佳实施例，该等数量可为一或二个(或组)以上，于此不再赘述。The circuit system 11 has two groups of circuit connection parts 111 and two groups of detection electrodes 112. The circuit connection part 111 is located at the other end of the detection test piece 1 opposite to the detection area 10, and is connected to the detection electrodes 112 for a detection The device 2 is electrically assembled to transmit the detection signal to the detection device 2 for analysis. The detection electrode 112 is arranged in the reaction area 104, so that the reaction area 104 transmits a detection signal to the detection device 2 through the detection electrode 112. The detection electrode 112 has at least one working electrode and a reference electrode. The detection electrode 112 is The circuit connection part 111 is connected with a wire 113 . The number of the above-mentioned internal sampling gap 102B, reaction area 104, sampling channel 105 and detection electrode 112 is two (or groups), which is only a preferred embodiment of the present invention, and these numbers can be one or two (or groups) ) above and will not be repeated here.
请一并参阅图5，是本发明的第一实施例的检测试片的分解图。用以详细揭露检测试片1的结构，检测试片1包含一基板12、一间隔层13及一上盖片14，基板12位于检测试片1的检测区10具有一基板穿孔121，该基板穿孔121的周围具有二反应区104，基板穿孔121两侧设置有对应二反应区104的基板内凸部122，每一基板内凸部122是由基板穿孔121的边缘向基板穿孔121延伸凸出，即凸伸接近该基板穿孔121的中心部位。再者，该基板12上是设置有该电路连接部111、检测电极112及导线113，另该基板12两侧是各设有一基板外凸部123。Please also refer to FIG. 5 , which is an exploded view of the test strip according to the first embodiment of the present invention. It is used to disclose the structure of the test strip 1 in detail. The test strip 1 includes a substrate 12, a spacer layer 13 and a cover sheet 14. The substrate 12 is located in the detection area 10 of the test strip 1 and has a substrate through hole 121. The substrate There are two reaction areas 104 around the through hole 121, and substrate inner protrusions 122 corresponding to the two reaction areas 104 are provided on both sides of the substrate through hole 121, and each substrate inner protrusion 122 extends from the edge of the substrate through hole 121 to the substrate through hole 121. , that is, the protrusion protrudes close to the center of the through-substrate hole 121 . Furthermore, the circuit connection portion 111 , the detection electrode 112 and the wire 113 are disposed on the substrate 12 , and a convex portion 123 is disposed on both sides of the substrate 12 .
该间隔层13覆盖于基板12，裸露出该检测试片1的检测区10及电路连接部111，该间隔层13具有一检测用的通道间隔131，该通道间隔131是与基板12的基板穿孔121、基板内凸部122对应。当间隔层13覆盖于基板12时，该通道间隔131是形成该检测试片1(基板12与上盖片14间)的该检测区10。The spacer layer 13 covers the substrate 12, exposing the detection area 10 and the circuit connection portion 111 of the detection test piece 1. The spacer layer 13 has a channel spacer 131 for detection, and the channel spacer 131 is a substrate through hole with the substrate 12. 121 corresponds to the inner convex portion 122 of the substrate. When the spacer layer 13 covers the substrate 12 , the channel gap 131 forms the detection area 10 of the detection test strip 1 (between the substrate 12 and the upper cover 14 ).
该上盖片14覆盖于间隔层13上，该上盖片14具有一与该基板穿孔121相对的上盖穿孔141，该上盖穿孔141具有二侧与基板内凸部122对应的上盖内凸部142；另该上盖片14两侧对应该基板外凸部123是设有一上盖外凸部143，用以组合形成该外采样凸部103A，而上盖外凸部143与基板外凸部123间是形成该外采样缺口103B。The upper cover sheet 14 is covered on the spacer layer 13, and the upper cover sheet 14 has an upper cover through hole 141 opposite to the substrate through hole 121. Protrusion 142; In addition, the two sides of the upper cover sheet 14 corresponding to the outer protrusion 123 of the substrate are provided with an outer protrusion 143 of the upper cover to form the outer sampling protrusion 103A in combination, and the outer protrusion 143 of the upper cover and the outer protrusion of the substrate The outer sampling gap 103B is formed between the protrusions 123 .
本实施例的检测试片1由基板12、间隔层13及上盖片14堆栈而成，该基板穿孔121、通道间隔131及上盖穿孔141的重复孔位部分形成检测试片1的采样穿孔101。该通道间隔131使该二基板内凸部122及上盖内凸部142间形成该二内采样区102。该通道间隔131于该基板12及上盖片14间形成该采样穿孔101二侧的采样通道105，用以连接内采样区102、采样穿孔101及二反应区104。再者，前述该检测试片1的定位件106若为穿孔时，则该基板12、间隔层13、上盖片14是分别对应设有穿孔状的基板定位件124、隔层定位件132、上盖定位件144；若该定位件106为切口时，则该切口是设于基板12、间隔层13或上盖片14的侧边(未图示)；若该定位件106为凸块时，则该凸块是设于基板12或上盖片14上(未图示)。The detection test piece 1 of this embodiment is formed by stacking the substrate 12, the spacer layer 13 and the upper cover sheet 14. The repeated hole positions of the substrate through-holes 121, the channel intervals 131 and the upper cover through-holes 141 form the sampling perforations of the detection test piece 1. 101. The channel interval 131 makes the two inner sampling regions 102 formed between the two inner convex portions 122 of the substrate and the upper cover inner convex portion 142 . The channel spacer 131 forms sampling channels 105 on both sides of the sampling through hole 101 between the substrate 12 and the upper cover 14 for connecting the inner sampling area 102 , the sampling through hole 101 and the two reaction areas 104 . Furthermore, if the aforementioned positioning piece 106 of the detection test piece 1 is perforated, then the substrate 12, the spacer layer 13, and the upper cover sheet 14 are respectively provided with perforated substrate positioning pieces 124, interlayer positioning pieces 132, The upper cover positioning member 144; if the positioning member 106 is a cutout, the cutout is located on the side of the substrate 12, the spacer layer 13 or the upper cover sheet 14 (not shown); if the positioning member 106 is a bump , the bump is provided on the substrate 12 or the upper cover 14 (not shown).
当采样穿孔101采集血液时，由于该内采样区102接近采样穿孔101，使检体4(或血液)能够快速接触该内采样缺口102B，该血液再利用毛细现象透过该采样通道105进入二反应区104，并使该反应区104产生电流讯号而继透过该检测电极112、导线113传输至该电路连接部111。When the sampling perforation 101 collects blood, because the inner sampling area 102 is close to the sampling perforation 101, the specimen 4 (or blood) can quickly contact the inner sampling notch 102B. the reaction area 104 , and make the reaction area 104 generate a current signal and transmit it to the circuit connection part 111 through the detection electrode 112 and the wire 113 .
请参阅图6至图11，用以说明该检测试片1的各层组合变化例，如图6、图6A所示，该上盖片14及基板12分别设有上盖穿孔141、上盖内凸部142及基板穿孔121、基板内凸部122，该上盖内凸部142及基板内凸部122为大小相同对称且组合成该内采样区102。如图7、图7A所示，该上盖内凸部142及基板内凸部122为大小不同而组合成该内采样区102。如图8、图8A所示，该基板12的基板穿孔121是呈一圆孔而不具该基板内凸部122，而该上盖片14的上盖内凸部142是单独形成该内采样区102。如图9、图9A所示，该上盖片14的上盖穿孔141是呈一圆孔而不具该上盖内凸部142，而该基板12的基板内凸部122是单独形成该内采样区102。如图10、图10A所示，该上盖片14的上盖穿孔141是呈一小圆孔而不具该上盖内凸部142，而该基板12的基板内凸部122以及该上盖穿孔141与该基板穿孔121间的区域是共同形成该内采样区102。如图11、图11A所示，该上盖片14的上盖穿孔141是呈一小圆孔而不具该上盖内凸部142，而该基板12的基板穿孔121是呈一较大圆孔而不具该基板内凸部122，其中该上盖穿孔141是与该基板穿孔121为大小不同的孔位，该上盖穿孔141与该基板穿孔121间的区域是形成该内采样区102。在前述变化例中，该内采样凸部102A为该基板12上的一基板内凸部122与该上盖片14上的一上盖内凸部142各别或搭配组合所形成；该内采样区102是可为该内采样凸部102A与由不同孔位大小的该基板穿孔121与该上盖穿孔141间的区域各别或搭配组合所形成；该采样穿孔101为该基板穿孔121及上盖穿孔141的重复孔位部分所形成，其孔距为0.4mm～4mm。Please refer to Fig. 6 to Fig. 11, in order to illustrate the variation example of each layer combination of this detection test piece 1, as shown in Fig. 6, Fig. The inner convex part 142 , the substrate through hole 121 , the inner convex part 122 of the substrate, the inner convex part 142 of the upper cover and the inner convex part 122 of the substrate are of the same size and symmetrical and are combined to form the inner sampling area 102 . As shown in FIG. 7 and FIG. 7A , the inner convex portion 142 of the upper cover and the inner convex portion 122 of the substrate are combined to form the inner sampling area 102 with different sizes. As shown in Fig. 8 and Fig. 8A, the substrate through hole 121 of the substrate 12 is a circular hole without the inner convex portion 122 of the substrate, and the upper cover inner convex portion 142 of the upper cover sheet 14 forms the inner sampling area alone. 102. As shown in Fig. 9 and Fig. 9A, the upper cover perforation 141 of the upper cover sheet 14 is a circular hole without the inner convex portion 142 of the upper cover, and the inner convex portion 122 of the substrate 12 forms the inner sample separately. District 102. As shown in Fig. 10 and Fig. 10A, the upper cover perforation 141 of the upper cover sheet 14 is a small circular hole without the inner convex portion 142 of the upper cover, and the inner convex portion 122 of the substrate 12 and the upper cover through hole 141 and the area between the TSV 121 jointly form the inner sampling area 102 . As shown in Fig. 11 and Fig. 11A, the upper cover perforation 141 of the upper cover sheet 14 is a small circular hole without the inner convex portion 142 of the upper cover, while the substrate perforation 121 of the substrate 12 is a larger circular hole and Without the inner protrusion 122 of the substrate, the upper cover through hole 141 is a hole with a different size from the substrate through hole 121 , and the area between the upper cover through hole 141 and the substrate through hole 121 forms the inner sampling region 102 . In the foregoing variation example, the inner sampling convex portion 102A is formed separately or in combination with a substrate inner convex portion 122 on the substrate 12 and a upper cover inner convex portion 142 on the upper cover sheet 14; The area 102 can be formed by the inner sampling protrusion 102A and the area between the substrate through hole 121 and the upper cover through hole 141 of different hole sizes separately or in combination; the sampling through hole 101 is formed by the substrate through hole 121 and the upper cover through hole The cover through holes 141 are formed by repeated hole positions, and the hole pitch is 0.4mm˜4mm.
请参阅图12、图13，是本发明的第一实施例的使用状态图。如图所示，第一实施例所提供的检测试片1主要用于一兼具有采样及检测功能的检测装置2。检测装置2具有一采样模块21及一检测模块22，采样模块21位于检测模块22的一侧，并供应一采血针23。检测模块22具有一试片插槽221，试片插槽221为半开放式插槽，其供检测试片1的电路连接部111插设定位，而检测试片1是以具电路连接部111的一端由采样模块21往检测模块22方向插设入该试片插槽221。试片插槽221内具有一电性连接器222，使检测试片1的电路连接部111插入接触试片插槽221的电性连接器222。又，为便利该检测试片1的组装拆卸操作，该检测试片1邻近该检测区10的前端是可加以延长而形成一握持部107。Please refer to Fig. 12 and Fig. 13, which are diagrams of the usage state of the first embodiment of the present invention. As shown in the figure, the detection test piece 1 provided by the first embodiment is mainly used for a detection device 2 with both sampling and detection functions. The detection device 2 has a sampling module 21 and a detection module 22 , the sampling module 21 is located on one side of the detection module 22 and supplies a blood collection needle 23 . The detection module 22 has a test piece slot 221, the test piece slot 221 is a semi-open slot, and it is inserted and positioned for the circuit connection portion 111 of the detection test piece 1, and the detection test piece 1 is based on a circuit connection portion One end of 111 is inserted into the test strip slot 221 from the sampling module 21 toward the detection module 22 . There is an electrical connector 222 inside the test strip slot 221 , so that the circuit connection portion 111 of the test strip 1 is inserted into the electrical connector 222 that contacts the test strip slot 221 . Moreover, in order to facilitate the assembly and disassembly operation of the testing strip 1 , the front end of the testing strip 1 adjacent to the testing area 10 can be extended to form a gripping portion 107 .
该检测装置2的采样模块21具有一采样部211及一杆部212，杆部212供采血针23的装卸设置，并利用弹力使采血针23自动弹伸出采样部211，并刺破待测者的受测部位3以采得检体4(如血液)。采样部211的下方具有一采样开口211A，采样开口211A是供采血针23穿过。再者，该采样部211底部于采样开口211A周围是设置至少一试片定位件211D，试片定位件211D是对应该检测试片1的定位件106，如图所示，该试片定位件211D及定位件106是呈凸块与穿孔的对应实施例。The sampling module 21 of the detection device 2 has a sampling part 211 and a rod part 212. The rod part 212 is provided for the loading and unloading of the blood collection needle 23, and uses elastic force to make the blood collection needle 23 automatically bounce out of the sampling part 211, and pierce the sample to be tested. The test site 3 of the patient is collected to obtain a sample 4 (such as blood). A sampling opening 211A is provided below the sampling part 211 , and the sampling opening 211A is for the blood collection needle 23 to pass through. Furthermore, the bottom of the sampling part 211 is provided with at least one test piece positioning part 211D around the sampling opening 211A, and the test piece positioning part 211D is corresponding to the positioning part 106 of the detection test piece 1. As shown in the figure, the test piece positioning part 211D and the positioning member 106 are corresponding embodiments of bumps and perforations.
又如图13、图14所示，该检测装置2(采样部211)底部是可进一步设有成对的采样抵压凸件211B，采样抵压凸件211B设置于采样开口211A周围，该采样抵压凸件211B是可为条状、弧条状等凸件，本实施例的采样抵压凸件211B间具有二抵压缺口211C，二抵压缺口211C对应检测试片1的采样穿孔101两侧的二内采样凸部102A。As shown in Fig. 13 and Fig. 14, the bottom of the detection device 2 (sampling part 211) can be further provided with a pair of sampling pressing protrusions 211B, and the sampling pressing protrusions 211B are arranged around the sampling opening 211A. The pressing protrusion 211B can be strip-shaped, arc-shaped, etc. There are two pressing notches 211C between the sampling pressing protrusions 211B in this embodiment, and the two pressing notches 211C correspond to the sampling perforation 101 of the test piece 1 The two internal sampling protrusions 102A on both sides.
当检测试片1的电路连接部111插设于试片插槽221后，位于检测试片1的检测区10向采样部211的采样开口211A靠近，使位于采样开口211A周围的试片定位件211D插设于检测试片1的定位件106，用以定位检测试片1的检测区10于检测装置2下方，使采样开口211A准确地对应检测试片1的采样穿孔101，以供采血针23准确地穿过进行穿刺采样。而该检测试片1前端的握持部107为凸伸出该检测装置2前端(或两侧)，使便利该检测试片1的装设及取下操作。检测时，由于该采样抵压凸件211B是穿过采样穿孔101凸出，用以抵压待测者的受测部位3，使受测部位3受挤压，当采血针23刺破待测者的受测部位3时可加快检体4渗出速度，并提供足够的检体量，此时检体4将迅速地由采样穿孔101两侧的二内采样缺口102B进入该采样通道105，当检体4流到二反应区104后，检测装置2提供一电压产生一检测讯号，该检测讯号透过检测试片1的电路连接部111传送至检测模块22，检测模块22分析检测讯号以得到检体4的浓度及相关状态的数据。After the circuit connection part 111 of the detection test piece 1 is inserted into the test piece slot 221, the detection area 10 located in the detection test piece 1 approaches the sampling opening 211A of the sampling part 211, so that the test piece positioning member located around the sampling opening 211A 211D is inserted into the positioning piece 106 of the detection test piece 1 to position the detection area 10 of the detection test piece 1 under the detection device 2, so that the sampling opening 211A accurately corresponds to the sampling perforation 101 of the detection test piece 1 for blood collection needles 23 accurately through the puncture sampling. The gripping portion 107 at the front end of the detection test piece 1 protrudes out of the front end (or both sides) of the detection device 2 to facilitate the installation and removal of the detection test piece 1 . During detection, since the sampling pressing protrusion 211B protrudes through the sampling perforation 101, it is used to press the tested part 3 of the subject to be tested, so that the tested part 3 is squeezed, and when the blood collection needle 23 pierces the tested part When the test site 3 of the patient is tested, the oozing speed of the sample 4 can be accelerated, and sufficient sample volume can be provided. At this time, the sample 4 will quickly enter the sampling channel 105 from the two inner sampling gaps 102B on both sides of the sampling perforation 101, When the sample 4 flows into the second reaction area 104, the detection device 2 provides a voltage to generate a detection signal, which is transmitted to the detection module 22 through the circuit connection part 111 of the detection test piece 1, and the detection module 22 analyzes the detection signal to Data on the concentration and related state of the sample 4 are obtained.
请参阅图15至图18，用以说明检测试片1的变化实施例，该检测试片1于该采样穿孔101的周围是设有一抵压凸出件108，该抵压凸出件108是可呈一环状凸体(或其它形状)，使用时该抵压凸出件108向下接触抵压待测者的受测部位3，待采血针23穿过采样穿孔101后，促使受测部位3的检体4快速渗出，以提供足够的检体量。该抵压凸出件108可设于该基板穿孔121、该通道间隔131(未图示)或该上盖穿孔141的周围，其中该抵压凸出件108的高度为0.01mm～2mm。前述图15至图17中，该检测试片1的抵压凸出件108是设于该上盖片14上而由该上盖片14向外凸出，使用时是将该检测试片1翻转，使该抵压凸出件108抵压受测部位3；而在图18中，该检测试片1的抵压凸出件108是设于该基板12上而由该基板12向外凸出，同样可达到检测试片1对受测部位3进行抵压采样的作用。Please refer to Fig. 15 to Fig. 18, in order to illustrate the embodiment of the variation of the detection test piece 1, the detection test piece 1 is provided with a pressing protrusion 108 around the sampling perforation 101, and the pressing protrusion 108 is It can be a ring-shaped convex body (or other shapes). When in use, the pressing protruding member 108 contacts and presses the tested part 3 of the subject to be tested. After the blood collection needle 23 passes through the sampling perforation 101, the tested Specimen 4 at site 3 oozes out quickly to provide a sufficient volume of the specimen. The resisting protrusion 108 can be disposed around the substrate through hole 121 , the channel gap 131 (not shown) or the upper cover through hole 141 , wherein the height of the resisting protrusion 108 is 0.01 mm˜2 mm. In the foregoing Figures 15 to 17, the pressing protrusion 108 of the detection test piece 1 is set on the upper cover sheet 14 and protrudes outward from the upper cover sheet 14. When in use, the detection test piece 1 Flip over so that the pressing protruding piece 108 is pressed against the tested part 3; and in FIG. It can be seen that the function of the detection test piece 1 to carry out pressure sampling on the tested part 3 can also be achieved.
上述可知，本发明提供一种检测试片，该检测试片是利用电化学检测，其于采样穿孔设置可采集导引检体的内采样区，内采样区上的内采样缺口易于吸取并导引检体进入反应区产生电化学反应。该检测试片更可于采样穿孔的周围设置抵压凸出件，抵压凸出件可抵压待测者的受测部位，以加速检体从受测部位渗出而进入反应区产生电化学反应。本发明更提供一种搭配本发明的检测试片的检测装置，该检测装置同时兼具采样及检测的功能，其结构简单，有效降低成本；另外，由于使用时采样部与受测者间隔有该检测试片，而检测试片可为一次性使用，通过一次性使用技术手段去避免使用者间的交互感染，以提供公共卫生的使用。As can be seen from the above, the present invention provides a detection test piece. The detection test piece utilizes electrochemical detection, and an inner sampling area that can collect and guide the specimen is set in the sampling perforation. The inner sampling gap on the inner sampling area is easy to absorb and guide. The sample is introduced into the reaction zone to generate an electrochemical reaction. The detection test piece can be provided with a pressing protruding piece around the sampling perforation, and the pressing protruding piece can be pressed against the tested part of the subject to accelerate the sample to seep out from the tested part and enter the reaction area to generate electricity. chemical reaction. The present invention further provides a detection device matching the detection test piece of the present invention. The detection device has the functions of sampling and detection at the same time. Its structure is simple and the cost is effectively reduced; The detection test piece can be used for one-time use, and the cross-infection among users can be avoided through the technical means of one-time use, so as to provide public health use.
综上所述，仅为本发明的较佳实施例而已，并非用来限定本发明实施的范围，凡依本发明权利要求范围所述的形状、构造、特征及精神所为的均等变化与修饰，均应包括于本发明的权利要求范围内。In summary, these are only preferred embodiments of the present invention, and are not intended to limit the scope of the present invention. All equivalent changes and modifications are made in accordance with the shape, structure, characteristics and spirit described in the scope of the claims of the present invention. , should be included in the scope of the claims of the present invention.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110035608.4ACN102613978B (en) | 2011-01-31 | 2011-01-31 | Test strip |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110035608.4ACN102613978B (en) | 2011-01-31 | 2011-01-31 | Test strip |
| Publication Number | Publication Date |
|---|---|
| CN102613978A CN102613978A (en) | 2012-08-01 |
| CN102613978Btrue CN102613978B (en) | 2014-12-03 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110035608.4AExpired - Fee RelatedCN102613978B (en) | 2011-01-31 | 2011-01-31 | Test strip |
| Country | Link |
|---|---|
| CN (1) | CN102613978B (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112294301B (en)* | 2019-08-02 | 2024-12-31 | 华广生技股份有限公司 | Physiological signal sensor device |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1554019A (en)* | 2001-09-11 | 2004-12-08 | ������������ʽ���� | Measuring instruments, mounting bodies and concentration measuring devices |
| CN101241141A (en)* | 2007-02-08 | 2008-08-13 | 厚美德生物科技股份有限公司 | Detection test piece with identification and detection device thereof |
| CN101351153A (en)* | 2006-03-22 | 2009-01-21 | 松下电器产业株式会社 | Biosensors and Component Concentration Measuring Devices |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4594487B2 (en)* | 2000-04-06 | 2010-12-08 | 新コスモス電機株式会社 | Constant potential electrolytic gas sensor |
| EP1411352B1 (en)* | 2001-07-13 | 2012-01-11 | ARKRAY, Inc. | Analysing instrument and lancet-integrated attachment for concentration measuring device |
| JP4334969B2 (en)* | 2003-10-02 | 2009-09-30 | パナソニック株式会社 | Blood component analysis sensor |
| EP2147305A4 (en)* | 2007-04-27 | 2010-05-05 | Abbott Diabetes Care Inc | Test strip identification using conductive patterns |
| US8337422B2 (en)* | 2009-07-14 | 2012-12-25 | Becton, Dickinson And Company | Diagnostic test strip having fluid transport features |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1554019A (en)* | 2001-09-11 | 2004-12-08 | ������������ʽ���� | Measuring instruments, mounting bodies and concentration measuring devices |
| CN101351153A (en)* | 2006-03-22 | 2009-01-21 | 松下电器产业株式会社 | Biosensors and Component Concentration Measuring Devices |
| CN101241141A (en)* | 2007-02-08 | 2008-08-13 | 厚美德生物科技股份有限公司 | Detection test piece with identification and detection device thereof |
| Title |
|---|
| JP特開2001-289816A 2001.10.19* |
| Publication number | Publication date |
|---|---|
| CN102613978A (en) | 2012-08-01 |
| Publication | Publication Date | Title |
|---|---|---|
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