CN102526875A - Digital insomnia therapeutic apparatus and treatment method - Google Patents

Abstract

Translated fromChinese

本发明公开一种数字失眠治疗仪及治疗方法，该数字失眠治疗仪包括电针或电极片，还包括中央处理器、分别连接在该中央处理器上的存储器、睡眠脑电采集模块、睡眠节律提取模块、睡眠节律组合模块、以及依次连接在睡眠节律组合模块和电针或电极片之间的D/A转换电路、滤波电路、采样电路、脉冲放大电路；籍此，对睡眠脑电信号进行采集→提取→组合→数模转换→滤波→采样→放大，形成医用脉冲信号，该医用脉冲信号加于针灸针或电极片上，通过相关穴位导入失眠患者的大脑，以诱导患者大脑产生睡眠脑电波或加强患者大脑已产生的较微弱的睡眠脑电波，使患者进入睡眠状态，并逐步进入深睡眠状态。

The invention discloses a digital insomnia treatment instrument and a treatment method. The digital insomnia treatment instrument includes electric acupuncture or electrode sheets, a central processing unit, a memory connected to the central processing unit, a sleep EEG acquisition module, and a sleep rhythm The extraction module, the sleep rhythm combination module, and the D/A conversion circuit, filter circuit, sampling circuit, and pulse amplification circuit sequentially connected between the sleep rhythm combination module and the electroacupuncture or the electrode sheet; Acquisition→extraction→combination→digital-to-analog conversion→filtering→sampling→amplification to form a medical pulse signal. The medical pulse signal is added to acupuncture needles or electrode sheets and introduced into the brain of insomnia patients through relevant acupoints to induce sleep brain waves in the patient’s brain. Or strengthen the weak sleep brain waves that the patient's brain has produced, so that the patient enters a sleep state and gradually enters a deep sleep state.

Description

Numeral apparatus for curing insomnia and Therapeutic Method

Technical field

The present invention relates to a kind of Medical Instruments, specifically a kind of instrument of Cure for insomnia and Therapeutic Method.

Background technology

Insomnia is meant starting and keeping obstacle of sleep, causes the quality and quantity of sleep can not satisfy individual physiological need and the activity on patient daytime is had tangible harmful effect, and unusual syndrome appears in objective detection simultaneously.According to document Cochran H. Diagnose and treat primary insomnia [J]. Nurse Pract, 2003,28:15. record; Epidemiological study shows; The insomnia incidence rate is 32%～35% in the American population, and Britain 10%～14%, Finland are 11.9%; West Germany is 15%, and Japan is 21%.The direct economic loss that causes because of insomnia only nineteen ninety-five in the U.S. up to 13,900,000,000 dollars.Long-term insomniac except that serious contingency and wound sickness rate apparently higher than the normal person that sleeps; (data is referred to document Balter MB. Uhlenhuth EH. New epidemiologic findings about insomnia and it treatment [J] .J Clin Psychiatry also can to bring out anxiety, depression or more than 80 kinds of diseases such as hypertension, diabetes; 1992; 53 [12, suppl]: 34), seriously influenced people's physical and mental health and obstruction social function.Therefore, scholars have carried out many trials, have invented a lot of medicines and have come Cure for insomnia.

; Although the direction and goal of new drug development is very clear and definite; Sleeping pill is also constantly weeded out the old and bring forth the new, and the listing of new drug can both overcome some shortcomings of previous generation at every turn, but is at present that a line or the sleeping pill of two wires all are difficult to solve the side reaction problems such as reaction and addiction property of being still drank after a night all the time; Cause its application to be subject to many limitations, this also impels people that the single medicine research and development are turned to other short dormancy therapy studies.

Utilizing acupuncture (thorn) Cure for insomnia is the another contribution of Chinese medicine, and numerous scholars have carried out Research on Mining and clinical trial to this, obtained very good effect.Along with scientific technological advance, people combine modern electronic technology with traditional acupuncture, have produced new Therapeutic Method such as electroacupuncture treatment insomnia and music electric needle Cure for insomnia again.Electroacupuncture treatment is after traditional acupuncture needle stimulates human's collateral channels and acupoints to bring about the desired sensation, and realization is cured the disease or the Therapeutic Method of anti-pain to replace the maneuver stimulation on pin, to pass to electric pulse, tolerates but the normal pulsed acusector is prone to generation to body; Musical Electro-acupuncture Therapy is that music signal is amplified through transducing, produces and the synchronous Low Medium Frequency electric current pulse of music, and outputs on the acusector.The waveform of this current impulse, frequency, amplitude change with music, can import music rhythm to the acupuncture point, can overcome the human body adaptability that common acusector causes easily again.But it is pointed out that by the converted pulse that outputs to acusector of music, because its frequency can not be too high; Be generally less than 100Hz, and the frequency band broad of music signal, according to Shannon's sampling theorem; Will inevitably lost part music composition, this is the weak point of music electric needle.

Brain electricity biofeedback is a kind of be used to remove physiology and uncomfortable new method of psychology; It shows through collection experimenter's EEG signals and with certain mode; Utilize the operant conditioning reflex pattern; Make the experimenter control self brain wave pattern consciously through award and reinforcement, reach and remove physiology and the uncomfortable purpose of psychology.Researcher and medical workers all are devoted to this technology to be used to remove people's anxiety and intense strain, and are used for treatment such as diseases such as brain internal injury, excessive drinking, mental disorders, in clinical practice, have obtained certain effect.

Utilizing brain electricity biofeedback principle Cure for insomnia disease, is one of present research focus.Preliminary study result shows, brain electricity biofeedback can be effective and stable influences brain electrical acti, finally makes insomniac's the sleep function and the function normalization on daytime.Document [Jiang Kai; Hu Guichi; Liu Ping etc. based on the novel E.E.G physiotherapy table [J] of biofeedback technology. instrumental technique; 2008; 7:47-49] development the E.E.G physiotherapy table based on biofeedback can produce 2Hz, 15Hz electric impulse signal; The flash of light and double track

rhythm and pace of moving things music that are aided with 15Hz are with rhythmic sound, photostimulation human brain acupuncture point nervous system and people's eyes, ears or optic nerve, to bring out and to strengthen required

brain wave; Make people's emotion of can releiving; Fatigue alleviating strengthens the study hope, reaches the purpose of physical therapy.Document [Zhang Guoguang; Li Lexia. the development of brain wave bio-feedback therapeutic apparatus [J]. the Chinese medicine physics magazine; 1998,15 (1): 53-54] reported a kind of brain wave bio-feedback therapeutic apparatus, it uses the flash stimulation optic nerve of CF; Bring out specific brain wave rhythm, reach the purpose that makes the people get into the state of consciousness of hope.

Aspect patent; Chinese patent 200910098967.7 discloses a kind of " intelligent insomnia therapeutic instrument "; This therapeutic instrument is gathered insomniac's brain wave in real time, and the brain wave of gathering is carried out frequency reducing or raising frequency, produces the time-varying magnetic field that is used to treat through amplifying the rear drive magnetic field generator.What it adopted is the short dormancy principle in magnetic field.Chinese invention patent ZL200720125136.0 discloses " a kind of apparatus for curing insomnia "; Produce a kind of low frequency random wave carrier pulse is carried out pulse amplitude modulation; And convert the amplitude modulation rectangular wave pulse into exponential damping amplitude-modulated pulse ripple; Be added to the patients of cerebellar roof nucleus by body surface self-adhering electrode sheet mastoid process position behind the human body ear, reach the purpose of Cure for insomnia.

The method of above-mentioned bibliographical information and patented technology all aspect the non-drug therapy of inquiring into insomnia, have obtained certain achievement, receive the certain short dormancy or the effect of Cure for insomnia.The present invention has the different of essence at aspects such as short dormancy mechanism, short dormancy method and short dormancy media with the method and the patented technology of above-mentioned bibliographical information.

Summary of the invention

In view of this, the present invention is directed to the disappearance of prior art existence, its main purpose provides a kind of digital apparatus for curing insomnia and Therapeutic Method; It is based on the biofeedback principle; And make full use of modern technologies brain wave is optimized integration processing, make this apparatus for curing insomnia have the medical pulse signal of brain wave characteristic, through stimulation to the relevant acupuncture point of human body; Under the specificity conduction of meridians; Electroencephalo and central neurotransmitter are produced positive feedback effect, thereby strengthen the natural sleep function that the insomniac is gone down, reach the Cure for insomnia purpose.

For realizing above-mentioned purpose, the present invention adopts like the purgation technical scheme:

A kind of digital apparatus for curing insomnia; Comprise acusector or electrode slice, also comprise central processing unit, be connected to memorizer, sleep cerebral electricity acquisition module, sleep rhythm extraction module, the sleep rhythm composite module on this central processing unit and be connected to the sleep rhythm composite module in turn and acusector or electrode slice between D/A change-over circuit, filter circuit, sample circuit, pulse amplifying circuit;

Under the control of central processing unit; This sleep cerebral electricity acquisition module is gathered insomniac or other sleep normal persons' sleep cerebral electricity signal; The sleep rhythm that this sleep rhythm extraction module extracts the sleep cerebral electricity signal is stored in the memorizer, and during treatment, this sleep rhythm composite module makes up the sleep rhythm that is extracted; Form synthetic sleep cerebral electricity signal; This synthetic sleep cerebral electricity signal carries out digital-to-analogue conversion, filtering, sampling, amplification through D/A change-over circuit, filter circuit, sample circuit, pulse amplifying circuit, forms all adjustable medical pulse signal of frequency, dutycycle, amplitude that contains sleep cerebral electricity information, and this medical pulse signal is added on acusector or the electrode slice; Brain through acupuncture point importing insomniac impels the insomniac to get into sleep.

Preferably; ripple of ripple when

ripple the when sleep rhythm that said sleep rhythm extraction module and sleep rhythm composite module extract and make up is deep sleep, shallow sleeping and tranquil relaxation state; Be somebody's turn to do

wave frequency less than 4Hz; Should

wave frequency be 4～8Hz, should

wave frequency be 8～l3Hz.

What preferably, said sleep cerebral electricity acquisition module was connected with that sleep cerebral electricity signal to insomniac or other sleep normal persons carries out the off-line collection leads the electroencephalogram Acquisition Instrument more.

Preferably, said sleep cerebral electricity acquisition module is connected with and leads electroencephalogram Acquisition Instrument to what the insomniac's that receiving treatment sleep cerebral electricity signal was gathered in real time more.

Preferably; Further include supervisory keyboard and display; This supervisory keyboard is connected with central processing unit respectively with display; This supervisory keyboard and display form the medical pulse signal that is used to be provided with instrument output parameter, select the sleep cerebral electricity signal of treatment usefulness the source, select sleep rhythm combined therapy scheme and systematic parameter be set, and show the man machine interface of running status.

Preferably, have the potentiometer of a change amplification on the said pulse amplifying circuit, this potentiometer is an adjustable resistance.

A kind of method of Cure for insomnia; Sleep cerebral electricity signal to insomniac or other sleep normal persons is gathered; Extract wherein

;

and rhythm and pace of moving things; During treatment; According to deep sleep in the human sleep, shallowly sleep, rule that calmness is loosened; To that is extracted;

and

rhythm and pace of moving things makes up; Form synthetic sleep cerebral electricity signal; Through digital-to-analogue conversion, filtering, sampling, amplification; Formation contains all adjustable medical pulse signal of frequency, dutycycle, amplitude of sleep cerebral electricity information; This medical pulse signal is added on acupuncture needle or the electrode; Pass through the acupuncture point; These signals with sleep cerebral electricity information are imported insomniac's brain; To induce patient's brain to produce sleeping brain wave or to strengthen the fainter sleeping brain wave that patient's brain has produced, make the patient get into sleep state.

Preferably; Said

;

and rhythm and pace of moving things makes up by

mode; Wherein, combination coefficient

,

,

.

Preferably, the acquisition mode of said sleep cerebral electricity signal be to the insomniac or the sleep normal person the sleep cerebral electricity signal carry out the off-line collection.

Preferably; The acquisition mode of said sleep cerebral electricity signal is the insomniac's that receiving treatment of real-time collection a sleep cerebral electricity signal; And,

and

rhythm and pace of moving things of sleep cerebral electricity signal are extracted in processing in real time; Judge insomniac's sleep quality according to the distribution situation of

,

and

rhythm and pace of moving things in the sleep cerebral electricity signal of insomniac's feedback; In real time,

, and

rhythm and pace of moving things are made up in adjustment automatically, form new sleep cerebral electricity signal.

The present invention compared with prior art has tangible advantage and beneficial effect; Particularly; Can know by technique scheme; This numeral apparatus for curing insomnia is to be formed by central processing unit, D/A converter, filter circuit, sample circuit, pulse amplifying circuit, memorizer, sleep cerebral electricity acquisition module, sleep rhythm extraction module and sleep rhythm composite module and acusector or electrode slice combination; To the sleep cerebral electricity signal gather → extract → make up → digital-to-analogue conversion → filtering → sampling → amplification, form all adjustable medical pulse signal of frequency, dutycycle, amplitude contain sleep cerebral electricity information, this medical pulse signal is added on acupuncture needle or the electrode slice; Through relevant acupuncture point, these signals with sleep cerebral electricity information are imported insomniac's brain.Take this; The present invention is at aspects such as short dormancy mechanism, short dormancy method and short dormancy media; With traditional method and patented technology the different of essence are arranged; Because handled

;

and

sleep rhythm is to derive from human body itself; After being converted into signal with sleep cerebral electricity information; Its own sleep cerebral electricity signal of human body that produces vibration of the frequency of its vibration, amplitude and stimulation has concordance; Cause the sympathetic response vibration of intracranial neutral net; Alternately stimulating of different frequency can be impelled the multiple neuropeptide with specific suitable frequency of maincenter secretion, and produces " working in coordination with " effect; Therefore; When some CFs of this signal (< 4Hz) are transmitted to corresponding brain region (like rapheal nuclei etc.), just can stimulate its secretion and sleep relevant neuropeptide and mediator (like 5-HT etc.), thereby reach Cure for insomnia or improve the effect of sleep quality.

In addition; Through sample circuit, pulse amplifying circuit being arranged between sleep rhythm composite module and acusector or the electrode slice; This sample circuit can change the frequency and the pulse width of sampling pulse, thereby can change the frequency and the dutycycle of the medical pulse signal of this digital apparatus for curing insomnia output; And; In this pulse amplifying circuit; The effect of potentiometer is the amplification that changes pulse amplifying circuit, thereby changes the amplitude of output pulse, therefore; Sample circuit and pulse amplifying circuit combine to make frequency, dutycycle and the amplitude of medical pulse signal all adjustable, help to different insomniacs different medical pulse signals being provided under different sleep states.

Also have; Because the sleep cerebral electricity acquisition module is to utilize to lead the electroencephalogram Acquisition Instrument more the insomniac's that receiving treatment sleep cerebral electricity signal is gathered in real time; These sleep cerebral electricity signals utilize after filtering, amplification and handle

that extracts wherein in real time;

and

rhythm and pace of moving things; In the sleep cerebral electricity signal according to the insomniac

; The distribution situation of

and

rhythm and pace of moving things is judged insomniac's sleep quality; In real time, adjust therapeutic scheme automatically; Thereby constitute brain electricity biological feedback system; In to insomniac's treatment; The feedback information of also receiving treatment; Real-time monitor treatment effect; The adjustment therapeutic scheme, therapeutic process is more intelligent.

For more clearly setting forth architectural feature of the present invention and effect, come the present invention is elaborated below in conjunction with accompanying drawing and specific embodiment.

Description of drawings

Fig. 1 is the system block diagram of the present invention's embodiment;

Fig. 2 is D/A change-over circuit and a filter circuit among the present invention's the embodiment;

Fig. 3 is the sample circuit of the present invention's embodiment;

Fig. 4 is a pulse amplifying circuit among the present invention's the embodiment;

Fig. 5 treats the insomnia system block diagram based on brain electricity biofeedback principle and digital apparatus for curing insomnia among the present invention's the embodiment;

Fig. 6 is the digital apparatus for curing insomnia therapeutic effect comparison diagram of common electrical needle therapeutic apparatus at present among the present invention's the embodiment.

The accompanying drawing identifier declaration:

1,central processing unit 2, external memory storage

3, D/A converter 4, filter circuit

5,sample circuit 6, pulse amplifying circuit

7, acusector (or self-adhering electrode sheet) 8, supervisory keyboard

9, LCD display 10, sleep cerebral electricity acquisition module

11, sleep rhythm extraction module 12, sleep rhythm composite module

13, lead the electroencephalogram Acquisition Instrument more.

The specific embodiment

The research of Electroencephalo shows; People's EEG signals generally comprise

;

,

and four kinds of basilic rhythms of

ripple.Arbitrary moment; Any rhythm and pace of moving things is occupied an leading position in the brain electricity; The state of consciousness that depends on this moment people: when sleeping soundly (phase during deep sleep); EEG signals are main with

ripple, and its frequency is less than 4Hz; Frequency be 4～8Hz be

ripple, the dim consciousness of (phase during shallow sleeping) is relevant with the dreamland appearance under main and the state just before going to bed; 8～l3Hz's is

ripple, is shown in the state that calmness is loosened usually; And when the people opens eyes and watch jobbie attentively,

ripple (> 13Hz then) dominate.Along with loosen, the change of state of vigilance, excitement and anxiety, brain wave frequency raises gradually, reaches as high as 35Hz.

It is thus clear that people's state of consciousness determines which kind of rhythm and pace of moving things to occur in the EEG signals or which kind of rhythm and pace of moving things is dominant; On the contrary, which kind of rhythm and pace of moving things is dominant in the EEG signals, and which kind of state of consciousness the decider is in.Therefore,, and it is preponderated in EEG signals, just can make the people be in desirable state of consciousness if can induce human brain to produce certain species rhythm; This just enlightens us; If can from insomniac or other people sleep cerebral electricity signal, extract

;

and

rhythm and pace of moving things ripple; And according to human sleep rule; With

that extract;

and

rhythm and pace of moving things carries out suitable combination; Form synthetic sleep cerebral electricity signal; Should synthesize the sleep cerebral electricity signal through conversion, amplification, form medical pulse signal.This medical pulse signal is added on the acusector (or self-adhering electrode sheet); Brain through relevant acupuncture point input insomniac; Probably induce or strengthen

of insomniac's brain generation; The sleep rhythm such as

and

or the rhythm and pace of moving things that helps sleeping; Make the patient get into sleep state, reach the purpose of short dormancy and Cure for insomnia.

Above-mentioned imagination has obtained the support of medical experiment and research.Research experiment and result show to have the relevant acupuncture point of specific stimulating electrical signal with some, and utilize the biophysical properties of meridians to the frequency conduction; With the brain of these electrical signal conduction, under it stimulates, cause the sympathetic response vibration of intracranial neutral net to the insomniac; And its initial electrical signal that produces vibration of the frequency of this vibration, amplitude and stimulation has concordance; Therefore, if stimulate the signal of telecommunication to adopt the sleep ripple, the vibration of brain sleeping brain wave is strengthened; On the other hand, present research shows: the periphery electricity irritation, and different frequencies can start different brain domains; Strengthen its functional activity; And the alternately stimulation of different frequency, also can impel the multiple neuropeptide of maincenter secretion, and produce " working in coordination with " effect with specific suitable frequency; Therefore; When some CFs of this signal (< 4Hz) are transmitted to corresponding brain region (like rapheal nuclei etc.), just can stimulate its secretion and sleep relevant neuropeptide and mediator (like 5-HT etc.), thereby reach Cure for insomnia or improve the effect of sleep quality.

Be directed to this; Please with reference to shown in Figure 1; The present invention designs a kind of digital apparatus for curing insomnia in order to the sleep quality that improves the insomniac with said method, and this numeral apparatus for curing insomnia comprisescentral processing unit 1,external memory storage 2, D/A change-overcircuit 3,filter circuit 4,sample circuit 5,pulse amplifying circuit 6, acusector 7 (or self-adhering electrode sheet),supervisory keyboard 8 and 9 nine parts of LCD display and sleep cerebral electricity acquisition module 10, sleep rhythm extraction module 11,12 3 modules of sleep rhythm composite module.Wherein, ripple when this sleep rhythm extraction module 11,

ripple when 12 rhythm and pace of moving things that extract and make up of sleep rhythm composite module are deep sleep, shallow sleeping and

ripple of tranquil relaxation state; Be somebody's turn to do

wave frequency less than 4Hz; Should

wave frequency be 4～8Hz, should wave frequency be 8～l3Hz.

Connectexternal memory storage 2,supervisory keyboard 8 and 9 three parts of LCD display in aforementioned sleep cerebral electricity acquisition module 10, sleep rhythm extraction module 11,12 3 modules of sleep rhythm composite module and aforementioned 9 parts on thiscentral processing unit 1 respectively; And D/A change-overcircuit 3,filter circuit 4,sample circuit 5,pulse amplifying circuit 6, acusector 7 (or self-adhering electrode sheet) are connected to sleep rhythm composite module 12 and acusector 7 (or self-adhering electrode sheet) in turn, export medical pulse signal by acusector 7 (or self-adhering electrode sheet).

Wherein, said sleep cerebral electricity acquisition module 10 utilizations are ledelectroencephalogram Acquisition Instrument 13 more and are gathered sleep normal person or insomniac's sleep cerebral electricity signal through the mode of real-time or off-line, and are stored in theexternal memory storage 2 of computer.

Said sleep rhythm extraction module 11 adopts modern signal processing technology such as wavelet transformation, Fourier transformation, digital filtering; Carry out off-line or processing in real time to gathering the sleep cerebral electricity signal that obtains; Extract

in the sleep cerebral electricity signal;

and

rhythm and pace of moving things, and be stored in theexternal memory storage 2.

During treatment; This sleep rhythm composite module 12 is according to mankind's rule of sleeping; To the sleep cerebral electricity rhythm and pace of moving things

that is extracted; and

makes up; Form a kind of synthetic sleep cerebral electricity digital signal

; Wherein,

,, be combination coefficient, determine by therapeutic scheme.For example; Because when sleeping soundly (phase during deep sleep), EEG signals are main with ripple; And

ripple main with state just before going to bed under the dim consciousness of (phase during shallow sleeping) relevant with the dreamland appearance;

ripple is shown in the state that calmness is loosened usually; And when the people opens eyes and watch jobbie attentively;

ripple dominate then; Therefore; In; if

,,

; Then synthetic sleep cerebral electricity digital signal be 3

; Belong to the deep sleep digital signal; When some CFs of this deep sleep digital signal (< 4Hz) are transmitted to corresponding brain region (like rapheal nuclei etc.); Just can stimulate its secretion and sleep relevant neuropeptide and mediator (like 5-HT etc.), thereby reach Cure for insomnia or improve the effect of sleep quality.

Fig. 2 is D/A change-overcircuit 3 andfilter circuit 4; This D/A change-overcircuit 3 adopts D/A converter TLV5616 to realize; This D/A converter TLV5616 has 8 pins, is respectively DIN pin, SCL pin,

pin, FS pin, VDD pin, KOUT pin, REFIN pin, AGN pin.This DIN pin is an input pin, VDD pin connection+5V dc source, and the REFIN pin connects 2V voltage, REFIN pin ground connection.

Saidfilter circuit 4 adopts the mode of capacitance-resistance filter; It comprises aresistance R 1 and acapacitor C 1; Thisresistance R 1 is 7k ohm, thiscapacitor C 1 be 1.One end ofresistance R 1 is connected on the output pin KOUT of D/A converter TLV5616, and the other end divides two-way, and one the tunnel is used to export sleep cerebral electricity analogue signal V1, and another road connectscapacitor C 1 back ground connection.

Above-mentioned synthetic sleep cerebral electricity digital signal

inputs to the DIN pin of the D/A converter TLV5616 among the figure; D/A converter TLV5616 converts analogue signal at following synthetic sleep cerebral electricity digital signal of the control ofcentral processing unit 1; Input to the low-pass filter circuit of forming by R1, C1 4 and carry out filtering, obtain synthetic sleep cerebral electricity analogue signal V1.

As shown in Figure 3, thissample circuit 5 adopts a kind of sampling/hold amplifier LF398 of feedback-type, and it has the sampling rate height, keeps voltage to descend slowly and the high characteristics of precision.Because sampling/hold amplifier LF398 is a device commonly used in the electronic technology, the connected mode of its concrete structure and 8 pins is no longer carefully stated at this.

Thesample circuit 5 that above-mentioned synthetic sleep cerebral electricity analogue signal V1 inputs to Fig. 3 is sampled, and sampling obtains the synthetic sleep cerebral electricity signal V2 of impulse form.Wherein, the sampling pulse ofcontrol sample circuit 5 work is produced by described central processing unit 1.The frequency of sampling pulse and pulse width; Frequency and the pulse width of the synthetic sleep cerebral electricity signal V2 of decision impulse form; Thereby determine the frequency and the dutycycle of the medical pulse signal that is used to treat that this digital apparatus for curing insomnia produces; Change the frequency and the pulse width of sampling pulse, can change the frequency and the dutycycle of the medical pulse signal of this digital apparatus for curing insomnia output.

Thepulse amplifying circuit 6 that the synthetic sleep cerebral electricity signal V2 of this impulse form inputs to Fig. 4 amplifies, and wherein, has apotentiometer 6 on thispulse amplifying circuit 6, and thispotentiometer 6 is an adjustable resistance.The effect of potentiometer R6 is the amplification that changespulse amplifying circuit 6, thereby changes the amplitude of output pulse.V2 formation afterpulse amplifying circuit 6 amplifies can drive the medical pulse signal that acusector 7 (or self-adhering electrode sheet) produces electricity irritation, i.e. EEG pulse among Fig. 4, and the frequency of this medical pulse signal, dutycycle and amplitude are all adjustable.

Described medical pulse signal (being the EEG pulse) is added on the acusector 7 (or self-adhering electrode sheet), and stimulation study confirms the effective Sishencong point of Cure for insomnia; According to through the cave---the relevant hypothesis of brain and through the low resistance high capacitance biophysical properties in cave; These stimulate the signal of telecommunication to import insomniac's brain along the passages through which vital energy circulates with electrology characteristic; Produce sleeping brain wave or strengthen the fainter sleeping brain wave that patient's brain has produced to induce or to strengthen patient's brain; Make the patient get into sleep state, reach the purpose of Cure for insomnia.

Saidsupervisory keyboard 8 is used for digital apparatus for curing insomnia is provided with, as source and other control parameters of the sleep cerebral electricity that frequency, dutycycle, the selection of the medical pulse signal of output be used to treat are set.LCD display 9 is used for display system setting and digital apparatus for curing insomnia running status.The man machine interface ofsupervisory keyboard 8 and the digital apparatus for curing insomnia of LCD display 9 formations.

This digital apparatus for curing insomnia also can be through leadingelectroencephalogram Acquisition Instrument 13 more, constitutes the digital apparatus for curing insomnia Cure for insomnia system based on brain electricity biofeedback and acupuncture moxibustion mechanism, and Fig. 5 is its system block diagram.In the system of Fig. 5; Lead the insomniac's thatelectroencephalogram Acquisition Instrument 13 receiving treatment through the real-time collection of multilead electrode sleep cerebral electricity signal more; These sleep cerebral electricity signals utilize after filtering, amplification and handle

that extracts wherein in real time;

and rhythm and pace of moving things; In the sleep cerebral electricity signal according to the insomniac; The distribution situation of

and

rhythm and pace of moving things is judged insomniac's sleep quality; In real time, automatically adjust therapeutic scheme, thereby constitute brain electricity biofeedback apparatus for curing insomnia.

It is following that principle of the present invention is detailed:

Utilize the sleep cerebral electricity signal of leadingelectroencephalogram Acquisition Instrument 13 collection sleep normal persons or insomniac more, and be stored in the memory device of computer; Adopt modern signal processing technology such as wavelet transformation, Fourier transformation, digital filtering; Carry out off-line or processing in real time to gathering the sleep cerebral electricity signal that obtains; Extract

in the sleep cerebral electricity signal; and rhythm and pace of moving things, and be stored in theexternal memory storage 2.

Under the control ofcentral processing unit 1; To

that is extracted;

and

rhythm and pace of moving things; Make up according to mankind's rule of sleeping, form a kind of synthetic sleep cerebral electricity digital signal; This synthetic sleep cerebral electricity digital signal converts analogue signal to through D/A change-over circuit 3, and by sendingsample circuit 5 to sample afterfilter circuit 4 filtering, the sampling pulse ofcontrol sample circuit 5 work is produced by described central controller.The frequency of sampling pulse and pulse width determine the frequency and the dutycycle of the medical pulse signal that is used to treat that this digital apparatus for curing insomnia produces.The synthetic sleep cerebral electricity signal of the impulse form that obtains throughover-sampling circuit 5 sampling is through filtering, amplification, and formation can drive the medical pulse signal that acusector 7 (or self-adhering electrode sheet) produces electricity irritation.

Described medical pulse signal is added on the acusector 7 (or self-adhering electrode sheet), and stimulation study confirms the effective Sishencong point of Cure for insomnia; According to through the relevant hypothesis of cave-brain with through the low resistance high capacitance biophysical properties in cave; These stimulate the signal of telecommunication to import insomniac's brain along the passages through which vital energy circulates with electrology characteristic; To induce patient's brain to produce sleeping brain wave or to strengthen the fainter sleeping brain wave that patient's brain has produced; Make the patient get into sleep state, and progressively get into the deep sleep state, reach the purpose of Cure for insomnia.

Below be the digital apparatus for curing insomnia that utilizes the present invention to animal (rat) result displayed when experimentizing:

Do experiment and shown the 5-HT nerve fiber that the back of the body of rat hypothalamus, nucleus lateralis are distributing abundant.And the pentobarbital rat model is after the numeral insomnia acupoint curing instrument of invention is treated 14 days; Show through the ELISA testing result; Experimental group rat hypothalamus 5-HT content increases to some extent, and according to bibliographical information, the content of hypothalamus 5-HT and the quality of sleep quality are proportionate.

Simultaneously, in conjunction with Fig. 6, compare with the common electrical needle therapeutic apparatus of background technology; The rat of identical sample size (10); In the treatment identical time (7 days), treat the pentobarbital sodium 30mg/kg of pneumoretroperitoneum injection same dose for the last time, display result is following:

(1) be 77. 46 ± 3. 75 minutes optimum curative effect length of one's sleep of common electrical needle therapeutic apparatus in the background technology.

(2) be 145.95 ± 23.05 minutes the length of one's sleep of the optimum curative effect (dutycycle 20%) of the present invention's numeral insomnia acupoint curing instrument.

Shown that by (1) and (2) two groups of data showing the more present common electrical needle therapeutic apparatus of the present invention's digital apparatus for curing insomnia has remarkable advantages and curative effect preferably on Cure for insomnia, the difference between the two has statistical significance.Therefore produce and the relevant neurotransmitter of sleeping (like 5-HT etc.) through the promotion maincenter, and content is obviously increased, thereby this method of order that reaches sleep has very high Practical significance.

In sum; Design focal point of the present invention is; This numeral apparatus for curing insomnia is to be formed by central processing unit, D/A converter, filter circuit, sample circuit, pulse amplifying circuit, memorizer, sleep cerebral electricity acquisition module, sleep rhythm extraction module and sleep rhythm composite module and acusector or electrode slice combination; To the sleep cerebral electricity signal gather → extract → make up → digital-to-analogue conversion → filtering → sampling → amplification; Formation contains all adjustable medical pulse signal of frequency, dutycycle, amplitude of sleep cerebral electricity information; This medical pulse signal is added on acupuncture needle or the electrode slice, through relevant acupuncture point, these signals with sleep cerebral electricity information is imported insomniac's brain.Take this; The present invention is at aspects such as short dormancy mechanism, short dormancy method and short dormancy media; With traditional method and patented technology the different of essence are arranged; Because handled;

and

sleep rhythm is to derive from human body itself; After being converted into signal with sleep cerebral electricity information; Its own sleep cerebral electricity signal of human body that produces vibration of the frequency of its vibration, amplitude and stimulation has concordance; Be easier to accepted, cause the sympathetic response vibration of intracranial neutral net, the alternately stimulation of different frequency by human brain; Also can impel the multiple neuropeptide of maincenter secretion with specific suitable frequency; And produce " work in coordination with " and act on, therefore, when some CFs of this signal (< 4Hz) are transmitted to corresponding brain region (like rapheal nuclei etc.); Just can stimulate its secretion and sleep relevant neuropeptide and mediator (like 5-HT etc.), thereby reach Cure for insomnia or improve the effect of sleep quality.

In addition; Through sample circuit, pulse amplifying circuit being arranged between sleep rhythm composite module and acusector or the electrode slice; This sample circuit can change the frequency and the pulse width of sampling pulse, thereby can change the frequency and the dutycycle of the medical pulse signal of this digital apparatus for curing insomnia output; And; In this pulse amplifying circuit; The effect of potentiometer is the amplification that changes pulse amplifying circuit, thereby changes the amplitude of output pulse, therefore; Sample circuit and pulse amplifying circuit combine to make frequency, dutycycle and the amplitude of medical pulse signal all adjustable, help to different insomniacs different medical pulse signals being provided under different sleep states.

Also have; Because the sleep cerebral electricity acquisition module is to utilize to lead the electroencephalogram Acquisition Instrument more the insomniac's that receiving treatment sleep cerebral electricity signal is gathered in real time; These sleep cerebral electricity signals utilize after filtering, amplification and handle that extracts wherein in real time; and

rhythm and pace of moving things; In the sleep cerebral electricity signal according to the insomniac

; The distribution situation of and

rhythm and pace of moving things is judged insomniac's sleep quality; In real time, adjust therapeutic scheme automatically; Thereby constitute brain electricity biological feedback system; In to insomniac's treatment; The feedback information of also receiving treatment; Real-time monitor treatment effect; The adjustment therapeutic scheme, therapeutic process is more intelligent.

The above; It only is preferred embodiment of the present invention; Be not that technical scope of the present invention is done any restriction, so every foundation technical spirit of the present invention all still belongs in the scope of technical scheme of the present invention any trickle modification, equivalent variations and modification that above embodiment did.

Claims (10)

Translated fromChinese

1.一种数字失眠治疗仪，包括电针或电极片，其特征在于：还包括中央处理器、分别连接在该中央处理器上的存储器、睡眠脑电采集模块、睡眠节律提取模块、睡眠节律组合模块、以及依次连接在睡眠节律组合模块和电针或电极片之间的D/A转换电路、滤波电路、采样电路、脉冲放大电路；1. A digital insomnia treatment instrument, comprising electroacupuncture or electrode sheet, is characterized in that: also comprises central processing unit, the memory that is respectively connected on this central processing unit, sleep EEG acquisition module, sleep rhythm extraction module, sleep rhythm Combination module, and D/A conversion circuit, filter circuit, sampling circuit, pulse amplifying circuit sequentially connected between the sleep rhythm combination module and the electric needle or electrode sheet;在中央处理器的控制下，该睡眠脑电采集模块采集失眠患者本人或其他睡眠正常人的睡眠脑电信号，该睡眠节律提取模块提取睡眠脑电信号的睡眠节律存储在存储器中，治疗时，该睡眠节律组合模块对所提取的睡眠节律进行组合，形成合成的睡眠脑电信号，该合成的睡眠脑电信号经D/A转换电路、滤波电路、采样电路、脉冲放大电路进行数模转换、滤波、采样、放大，形成含有睡眠脑电信息的频率、占空比、幅度均可调的医用脉冲信号，该医用脉冲信号加于电针或电极片上，通过穴位导入失眠患者的大脑，促使失眠患者进入睡眠。Under the control of the central processing unit, the sleep EEG acquisition module collects the sleep EEG signals of insomnia patients or other normal sleepers. The sleep rhythm extraction module extracts the sleep rhythm of the sleep EEG signals and stores them in the memory. During treatment, The sleep rhythm combination module combines the extracted sleep rhythms to form a synthesized sleep EEG signal, and the synthesized sleep EEG signal undergoes digital-to-analog conversion through a D/A conversion circuit, a filter circuit, a sampling circuit, and a pulse amplifier circuit. Filter, sample, and amplify to form a medical pulse signal with adjustable frequency, duty cycle, and amplitude containing sleep EEG information. The medical pulse signal is added to the electroacupuncture or electrode sheet, and is introduced into the brain of insomnia patients through acupuncture points to promote insomnia. The patient falls asleep.2.根据权利要求1所述的数字失眠治疗仪，其特征在于：所述睡眠节律提取模块和睡眠节律组合模块所提取和组合的睡眠节律为深睡眠时的                                               波、浅睡时的

波和平静放松状态的

波，该

波的频率小于4Hz，该

波的频率为4～8Hz，该

波的频率为8～l3Hz。2. digital insomnia treatment instrument according to claim 1, is characterized in that: the sleep rhythm that described sleep rhythm extraction module and sleep rhythm combination module extract and combine is deep sleep time wave, light sleep

waves and calm state of relaxation

wave, the

wave frequency less than 4Hz, the

The wave frequency is 4~8Hz, the

Wave frequency is 8 ~ l3Hz.3.根据权利要求1所述的数字失眠治疗仪，其特征在于：所述睡眠脑电采集模块连接有对失眠患者本人或其他睡眠正常人的睡眠脑电信号进行离线采集的多导脑电图采集仪。3. The digital insomnia treatment instrument according to claim 1, characterized in that: the sleep EEG acquisition module is connected with a multi-conductor electroencephalogram for off-line acquisition of the sleep EEG signals of insomnia patients or other normal sleepers Acquisition instrument.4.根据权利要求1所述的数字失眠治疗仪，其特征在于：所述睡眠脑电采集模块连接有对正在接受治疗的失眠患者的睡眠脑电信号进行实时采集的多导脑电图采集仪。4. digital insomnia therapeutic instrument according to claim 1, is characterized in that: described sleep EEG acquisition module is connected with the sleep EEG signal of the insomnia patient who is being treated and carries out real-time acquisition multi-channel EEG acquisition instrument .5.根据权利要求1所述的数字失眠治疗仪，其特征在于：进一步包括有控制键盘和显示器，该控制键盘和显示器分别与中央处理器连接，该控制键盘和显示器组成用于设置仪器输出的医用脉冲信号的参数、选择治疗用的睡眠脑电信号的来源、选择睡眠节律组合治疗方案及设置系统参数，并显示运行状态的人机界面。5. digital insomnia treatment instrument according to claim 1, is characterized in that: further comprise control keyboard and display, and this control keyboard and display are connected with central processing unit respectively, and this control keyboard and display form are used to set the instrument output Parameters of medical pulse signals, selection of source of sleep EEG signals for treatment, selection of sleep rhythm combination treatment plan and setting of system parameters, and a man-machine interface that displays the operating status.6.根据权利要求1所述的数字失眠治疗仪，其特征在于：所述脉冲放大电路上具有一改变放大倍数的电位器，该电位器为一可调电阻。6. The digital insomnia treatment device according to claim 1, characterized in that: said pulse amplifying circuit has a potentiometer for changing the amplification factor, and the potentiometer is an adjustable resistor.7.一种治疗失眠的方法，其特征在于：对失眠患者本人或其他睡眠正常人的睡眠脑电信号进行采集，提取其中的，

和节律，治疗时，依据人类睡眠中深睡眠、浅睡、平静放松的规律，对所提取的

，

和

节律进行组合，形成合成的睡眠脑电信号，经数模转换、滤波、采样、放大，形成含有睡眠脑电信息的频率、占空比、幅度均可调的医用脉冲信号，该医用脉冲信号加于针灸针或电极上，通过人体穴位，将这些具有睡眠脑电信息的信号导入失眠患者的大脑，以诱导患者大脑产生睡眠脑电波或加强患者大脑已产生的较微弱的睡眠脑电波，使患者进入睡眠状态。7. A method for treating insomnia, characterized in that: collecting the sleep EEG signals of the insomnia patient himself or other normal sleepers, extracting the ,

and Rhythm, during treatment, according to the laws of deep sleep, light sleep, calm and relaxation in human sleep, the extracted

,

and

Combine the rhythms to form a synthetic sleep EEG signal. After digital-to-analog conversion, filtering, sampling, and amplification, a medical pulse signal with adjustable frequency, duty cycle, and amplitude containing sleep EEG information is formed. The medical pulse signal is added On the acupuncture needles or electrodes, through the acupuncture points of the human body, these signals with sleep EEG information are introduced into the brains of insomnia patients, so as to induce the patients' brains to generate sleep brain waves or strengthen the weaker sleep brain waves already produced by the patients' brains, so that patients Go to sleep.8.根据权利要求7所述的治疗失眠的方法，其特征在于：所述，

和

节律按

方式进行组合，其中，组合系数

、

、

。8. the method for the treatment of insomnia according to claim 7, is characterized in that: the ,

and

Rhythm press

way to combine, where the combination coefficient

,

,

.9.根据权利要求7所述的治疗失眠的方法，其特征在于：所述睡眠脑电信号的采集方式是对失眠患者本人或睡眠正常人的睡眠脑电信号进行离线采集。9. The method for treating insomnia according to claim 7, characterized in that: the acquisition method of the sleep EEG signal is offline acquisition of the sleep EEG signal of the insomnia patient himself or a normal sleeper.10.根据权利要求7所述的治疗失眠的方法，其特征在于：所述睡眠脑电信号的采集方式是实时采集正在接受治疗的失眠患者的睡眠脑电信号，并实时处理提取睡眠脑电信号的

、

和

节律，根据失眠患者反馈的睡眠脑电信号中

、和

节律的分布情况判断失眠患者的睡眠情况，实时、自动调整组合

、

和

节律，形成新的睡眠脑电信号。10. The method for treating insomnia according to claim 7, characterized in that: the acquisition method of the sleep EEG signal is to collect the sleep EEG signal of the insomnia patient being treated in real time, and process and extract the sleep EEG signal in real time of

,

and

Rhythm, according to the sleep EEG signals fed back by insomnia patients

, and

The distribution of rhythm can judge the sleep condition of insomnia patients, and the combination can be adjusted automatically in real time

,

and

rhythm, forming a new sleep EEG signal.

Images