CN102500055A - Auxiliary implantable flexible microelectrode of non-absorbable suture line and production method thereof - Google Patents
Auxiliary implantable flexible microelectrode of non-absorbable suture line and production method thereofDownload PDFInfo
- Publication number
- CN102500055A CN102500055ACN2011103271285ACN201110327128ACN102500055ACN 102500055 ACN102500055 ACN 102500055ACN 2011103271285 ACN2011103271285 ACN 2011103271285ACN 201110327128 ACN201110327128 ACN 201110327128ACN 102500055 ACN102500055 ACN 102500055A
- Authority
- CN
- China
- Prior art keywords
- suture
- microelectrode
- flexible microelectrode
- flexible
- nonabsorbable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Electrotherapy Devices (AREA)
Abstract
Translated fromChinese
Description
Translated fromChinese技术领域technical field
本发明涉及的是一种医用器械技术领域的微电极，具体是一种面向瘫痪康复的不可吸收缝合线辅助植入式柔性微电极及其制备方法。The invention relates to a microelectrode in the technical field of medical devices, in particular to a non-absorbable suture-assisted implantable flexible microelectrode for paralysis rehabilitation and a preparation method thereof.
背景技术Background technique
近年来，随着微机电系统（MEMS: Micro-Electro-Mechanical Systems)技术的不断进步，使得微电子设备和微传感器等微系统应用范围不断扩大，已广泛应用于多个领域，特别是医学领域。In recent years, with the continuous advancement of MEMS (Micro-Electro-Mechanical Systems) technology, the application range of micro-systems such as micro-electronic devices and micro-sensors has continued to expand, and has been widely used in many fields, especially in the medical field. .
面向瘫痪康复的微电极是一个重要的应用。骨骼肌是由神经支配的，但是如果神经出现损伤，骨骼肌就会麻痹或者瘫痪，不能完成运动功能。如果使用微电极把功能性电刺激信号加载到目标肌肉或者目标部位上，那么骨骼肌就会得到一定程度的康复，恢复一部分或者全部运动机能。Microelectrodes for paralysis rehabilitation are an important application. Skeletal muscles are innervated by nerves, but if the nerves are damaged, the skeletal muscles will be paralyzed or paralyzed, unable to perform motor functions. If the microelectrode is used to load the functional electrical stimulation signal to the target muscle or target site, then the skeletal muscle will be recovered to a certain extent, and some or all of the motor functions will be restored.
目前，对于植入式微电极的植入方法有很多种，常见的有：外科手术切开组织，在目标部位植入微电极，适用于长期植入；把微电极放在空心注射针头中，利用注射针头刺入组织，完成植入，适用于临时植入及在解剖学上比较简单的目标部位植入。At present, there are many implantation methods for implantable microelectrodes, the common ones are: surgical incision of tissue, implanting microelectrodes at the target site, which is suitable for long-term implantation; placing microelectrodes in hollow injection needles, using The injection needle penetrates into the tissue to complete the implantation, which is suitable for temporary implantation and implantation at relatively simple target sites in anatomy.
对于外科手术植入的方法，一方面创伤较大，另一方面在微电极植入后，微电极比较容易发生移位，与一开始植入时的部位发生偏离，造成微电极的刺激效果变差等不利影响。对于注射针头辅助植入的方法，由于注射针头可以在较少创伤的情况下刺入较深部位，所以对于相关实验是比较有用的，但临床上也存在植入后微电极易于移动的缺点。另外，对于解剖上比较复杂的部位，使用注射针头辅助植入的方法还容易对其他组织造成损伤，引起难以预计的问题。For the method of surgical implantation, on the one hand, the trauma is relatively large, and on the other hand, after the microelectrode is implanted, the microelectrode is relatively easy to shift, which deviates from the initial implantation site, resulting in a change in the stimulation effect of the microelectrode. adverse effects. As for the needle-assisted implantation method, since the injection needle can penetrate deeper parts with less trauma, it is more useful for related experiments, but there is also the disadvantage that the microelectrode is easy to move after implantation clinically. In addition, for anatomically complex parts, the method of using needle-assisted implantation is also likely to cause damage to other tissues, causing unpredictable problems.
经对现有技术的检索发现，Sachs， N. A.， E. L. Chang等人在IEEE Trans Neural Syst Rehabil Eng 15(1): 67-75 ，2007撰文“Electrical stimulation of the paralyzed orbicularis oculi in rabbit”（用于兔子眼轮匝肌麻痹的电刺激），该技术采用在兔子上眼睑的皮下使用外科手术的方法植入刺激电极，并且在一定程度上实现了兔子的闭眼动作。但是对于需要长期植入的电极来说，这种方法会使电极比较容易滑动，偏离原来植入的部位，造成刺激效果变差，所以该方法在长期植入应用方面受到较多限制。After searching the prior art, it was found that Sachs, N. A., E. L. Chang et al wrote an article "Electrical stimulation of the paralyzed orbitalis oculi in IEEE Trans Neural Syst Rehabil Eng 15(1): 67-75, 2007 rabbit” (Electrical Stimulation for Rabbit Orbicularis Oculi Palsy), which uses surgical implantation of stimulating electrodes under the skin of the rabbit’s upper eyelid, and achieves the rabbit’s eye-closing movement to a certain extent. However, for electrodes that need to be implanted for a long time, this method will make the electrodes slide more easily and deviate from the original implanted site, resulting in poor stimulation effect. Therefore, this method is more limited in long-term implantation applications.
美国专利号：US8，010，200，“System for permanent electrode placement utilizing microelectrode recording methods”（一种利用微电极记录方法辅助放置永久微电极的系统），该技术公开了一种结合记录微电极与脑深部电刺激电极来改善植入电极部位的方法。该技术在脑深部电刺激电极中间做一个腔室，腔室容许记录微电极通过。可以根据需要，在植入脑深部电刺激电极之前，之后以及植入的过程中随时插入记录微电极来确定脑深部电刺激电极的植入位置是否合适。综上，目前对微电极植入方法的有关研究集中在植入时如何提高植入部位精确度的问题上，对由微电极植入后的长期部位精确度研究较少，因此，没有可用于长期保证微电极植入部位精确度的方法或系统。U.S. Patent No.: US8,010,200, "System for permanent electrode placement utilizing microelectrode recording methods" (a system that uses microelectrode recording methods to assist in the placement of permanent microelectrodes), this technology discloses a combination of recording microelectrode and brain Deep electrical stimulation electrodes to improve the method of implanting the electrode site. The technique creates a cavity in the middle of the deep brain stimulation electrodes, which allows the recording microelectrodes to pass through. According to needs, the recording microelectrode can be inserted at any time before, after and during the implantation of the deep brain electrical stimulation electrode to determine whether the implantation position of the deep brain electrical stimulation electrode is appropriate. In summary, the current research on microelectrode implantation methods focuses on how to improve the accuracy of the implanted site during implantation, and there are few studies on the long-term site accuracy after microelectrode implantation. A method or system for long-term assurance of microelectrode implant site accuracy.
发明内容Contents of the invention
本发明针对现有技术存在的上述不足，提供一种面向瘫痪康复的不可吸收缝合线辅助植入式柔性微电极及其制备方法，该柔性微电极植入时，操作相对简便，受过一般外科手术训练即可，能有效长期保证微电极植入部位精确度。Aiming at the above-mentioned deficiencies in the prior art, the present invention provides a nonabsorbable suture-assisted implantable flexible microelectrode for paralysis rehabilitation and a preparation method thereof. When the flexible microelectrode is implanted, the operation is relatively simple, and it has undergone general surgical operations. Training is enough, which can effectively ensure the accuracy of the microelectrode implantation site for a long time.
本发明是通过以下技术方案实现的：The present invention is achieved through the following technical solutions:
本发明所述的一种不可吸收缝合线辅助植入式柔性微电极，包括：柔性微电极、不可吸收缝合线材和医用缝合针，所述柔性微电极与所述不可吸收缝合线材螺旋缠绕在一起，所述不可吸收缝合线材与所述柔性微电极的结合末端处用聚二甲基硅氧烷固定。所述医用缝合针与不可吸收缝合线材两端连接。A non-absorbable suture-assisted implantable flexible microelectrode according to the present invention includes: a flexible microelectrode, a nonabsorbable suture wire and a medical suture needle, and the flexible microelectrode and the nonabsorbable suture wire are helically wound together , the joint end of the non-absorbable suture wire and the flexible microelectrode is fixed with polydimethylsiloxane. The medical suture needle is connected with both ends of the non-absorbable suture wire.
本发明上述不可吸收缝合线辅助植入式柔性微电极的制备方法，具体为：首先把柔性微电极与带线缝合针的不可吸收缝合线材螺旋缠绕在一起，然后在所述线材与柔性微电极的结合末端处涂抹聚二甲基硅氧烷，最后在烘箱中热处理即可。The preparation method of the above-mentioned nonabsorbable suture-assisted implantable flexible microelectrode of the present invention is specifically: firstly, the flexible microelectrode and the nonabsorbable suture wire material with a suture needle are helically wound together, and then the wire material and the flexible microelectrode Apply polydimethylsiloxane to the bonding end, and finally heat-treat in an oven.
上述制备方法中，所述的固定结合末端的聚二甲基硅氧烷的硅橡胶与固化剂的质量比为10:1。In the above preparation method, the mass ratio of the silicone rubber immobilizing the terminal polydimethylsiloxane to the curing agent is 10:1.
上述制备方法中，所述在烘箱中热处理是指在烘箱中70℃热处理6小时。In the above preparation method, the heat treatment in an oven refers to heat treatment in an oven at 70° C. for 6 hours.
本发明中，所述的柔性微电极可以是贵金属丝状微电极（如铂丝、铱丝、金丝等），聚合物微电极（如Parylene薄膜微电极、导电聚合物薄膜微电极等）中的一种。In the present invention, the flexible microelectrodes can be precious metal wire microelectrodes (such as platinum wires, iridium wires, gold wires, etc.), polymer microelectrodes (such as Parylene film microelectrodes, conductive polymer film microelectrodes, etc.) kind of.
本发明利用缝合线在组织中穿行方便，位置相对固定的特点，把柔性微电极与缝合线制备在一起，通过缝合线在组织中穿行时植入柔性微电极。这种方法可以利用外科缝合技术包括打结等方法固定柔性微电极与植入部位的相对位置。利用本发明植入柔性微电极，可操作性强，使用时只需要把制备好的带柔性微电极的缝合线使用外科缝合技术植入到目标组织内并固定即可，这样可以长期保证微电极植入部位的精确度。The invention utilizes the characteristics that the suture thread is convenient to pass through the tissue and its position is relatively fixed, and the flexible microelectrode and the suture thread are prepared together, and the flexible microelectrode is implanted when the suture thread passes through the tissue. In this method, surgical suturing techniques including knotting and other methods can be used to fix the relative position of the flexible microelectrode and the implantation site. Using the present invention to implant flexible microelectrodes has strong operability. When using it, it is only necessary to implant the prepared sutures with flexible microelectrodes into the target tissue using surgical suture technology and fix them, which can ensure the long-term maintenance of the microelectrodes. The precision of the implant site.
附图说明Description of drawings
图1 为本发明实施例所得电极的结构示意图。Fig. 1 is the structural representation of the electrode obtained in the embodiment of the present invention.
具体实施方式Detailed ways
下面对本发明的实施例作详细说明，本实施例在以本发明技术方案为前提下进行实施，给出了详细的实施方式和具体的操作过程，但本发明的保护范围不限于下述的实施例。The embodiments of the present invention are described in detail below. This embodiment is implemented on the premise of the technical solution of the present invention, and detailed implementation methods and specific operating procedures are provided, but the protection scope of the present invention is not limited to the following implementation example.
实施例1Example 1
如图1所示，实施例1制备得到的不可吸收缝合线辅助植入式柔性微电极包括：医用缝合针1、不可吸收缝合线材2、柔性微电极4、固定结合末端的聚二甲基硅氧烷5。As shown in Figure 1, the non-absorbable suture-assisted implantable flexible microelectrode prepared in Example 1 includes: medical suture needle 1, non-absorbable suture wire 2,
本实施例中，所述的医用缝合针1为商品化的各种外科用医用缝合针。In this embodiment, the medical suture needle 1 is a variety of commercial surgical suture needles.
本实施例中，所述的不可吸收缝合线材2为商品化的各种外科用不可吸收带线缝合针的线材。In this embodiment, the non-absorbable suture wire 2 is a commercially available non-absorbable suture needle with thread.
本实施例中，所述的柔性微电极4可以是贵金属丝状微电极（如铂丝、铱丝、金丝等），聚合物微电极（如Parylene薄膜微电极、导电聚合物薄膜微电极等）中的一种。In this embodiment, the
本实施例中，所述的柔性微电极4设有电极点3，柔性微电极电极点3可以是一个或者多个。In this embodiment, the
本实施例中，所述的柔性微电极电极点3的面积为1
本实施例中，所述的柔性微电极4的长度为10mm-150mm。In this embodiment, the length of the
本实施例中，所述的柔性微电极4的横截面积为100
本实施例中，所述的固定结合末端的聚二甲基硅氧烷5的厚度为50-200
本实施例中，在缠绕微电极时，医用缝合针1可以选择使用商品化的带缝合线的缝合针，也可以根据需要只选择使用其中的缝合针针头。In this embodiment, when winding the microelectrode, the medical suture needle 1 can be selected to use a commercialized suture needle with suture thread, or only the needle head of the suture needle can be selected according to needs.
所述的带线缝合针包括常见的商品化的涤纶、锦纶等线材的带线缝合针，线材的材料、直径与带线缝合针的材料、大小等均可以根据实际植入需要选择。The threaded suture needles include common commercial polyester, nylon and other threaded suture needles. The material and diameter of the thread and the material and size of the threaded suture needles can be selected according to actual implantation needs.
本实施例的工作原理为：如图1所示，柔性微电极4与不可吸收缝合线材2螺旋缠绕在一起，不可吸收缝合线材2与柔性微电极4的结合末端处用聚二甲基硅氧烷5固定，防止脱开。当使用外科缝合技术在组织中穿行时，柔性微电极4随着不可吸收缝合线材2在组织中穿行，当到达目标位置时，将不可吸收缝合线材2固定即可完成柔性微电极4的植入。然后将不可吸收缝合线材2打结，即可起到固定作用。打结的方向要顺着垂直于肌肉收缩的方向，防止把柔性微电极4拉断。其中，柔性微电极4要作为打结的部分或者全部参与，防止拆线后柔性微电极4相对于组织滑动。植入完成后，可以根据需要选择是否拆线。The working principle of this embodiment is: as shown in Figure 1, the
本实施例的实际应用要求所用尺寸如表1所示，表1 面向瘫痪康复的不可吸收缝合线辅助植入式柔性微电极的一组典型设计参数。The dimensions required for the practical application of this example are shown in Table 1. Table 1 A set of typical design parameters of non-absorbable suture-assisted implantable flexible microelectrodes for paralysis rehabilitation.
表1Table 1
实施例2Example 2
本实施例提供一种实施例1所述的不可吸收缝合线辅助植入式柔性微电极的制备方法，具体制备过程如下：首先把柔性微电极4（这里以铂丝电极为例）与不可吸收缝合线材2螺旋缠绕在一起，线材不能太松，以肉眼看到线材与铂丝电极接触为宜。然后在线材与铂丝电极的结合末端处涂抹适量的聚二甲基硅氧烷，最后在烘箱中70℃热处理6小时即可。This embodiment provides a preparation method of the nonabsorbable suture-assisted implantable flexible microelectrode described in Embodiment 1. The specific preparation process is as follows: firstly, the flexible microelectrode 4 (here, a platinum wire electrode is used as an example) is combined with a nonabsorbable suture The suture wire 2 is helically wound together, and the wire should not be too loose, and it is advisable to see the contact between the wire and the platinum wire electrode with the naked eye. Then apply an appropriate amount of polydimethylsiloxane to the joint end of the wire and the platinum wire electrode, and finally heat-treat in an oven at 70°C for 6 hours.
本实施例中，所述不可吸收缝合线材2与所述柔性微电极4的结合末端的聚二甲基硅氧烷5，其中的硅橡胶与固化剂的质量比为10:1。In this embodiment, the
本实施例中，在缠绕微电极时，医用缝合针1可以选择使用商品化的带缝合线的缝合针，也可以根据需要只选择使用其中的缝合针针头。In this embodiment, when winding the microelectrode, the medical suture needle 1 can be selected to use a commercialized suture needle with suture thread, or only the needle head of the suture needle can be selected according to needs.
所述的带线缝合针包括常见的商品化的涤纶、锦纶等线材的带线缝合针，线材的材料、直径与带线缝合针的材料、大小等均可以根据实际植入需要选择。The threaded suture needles include common commercial polyester, nylon and other threaded suture needles. The material and diameter of the thread and the material and size of the threaded suture needles can be selected according to actual implantation needs.
本实施例制备得到的不可吸收缝合线辅助植入式柔性微电极：柔性微电极与不可吸收缝合线材螺旋缠绕在一起，不可吸收缝合线材与柔性微电极的结合末端处用聚二甲基硅氧烷固定，医用缝合针与不可吸收缝合线材两端连接。The nonabsorbable suture-assisted implantable flexible microelectrode prepared in this example: the flexible microelectrode and the nonabsorbable suture wire are helically wound together, and polydimethylsiloxane is used at the joint end of the nonabsorbable suture wire and the flexible microelectrode Fixed with alkane, the medical suture needle is connected with both ends of the non-absorbable suture wire.
上述描述为本发明的优选实施例，本发明还可以是其他的实施形式，包括所用材料的配比变化以及尺寸变化等，这是本领域技术人员都可以理解的，在此不一一列举。The above description is a preferred embodiment of the present invention, and the present invention can also be implemented in other forms, including changes in the ratio and size of the materials used, which can be understood by those skilled in the art and will not be listed here.
尽管本发明的内容已经通过上述优选实施例作了详细介绍，但应当认识到上述的描述不应被认为是对本发明的限制。在本领域技术人员阅读了上述内容后，对于本发明的多种修改和替代都将是显而易见的。因此，本发明的保护范围应由所附的权利要求来限定。Although the content of the present invention has been described in detail through the above preferred embodiments, it should be understood that the above description should not be considered as limiting the present invention. Various modifications and alterations to the present invention will become apparent to those skilled in the art upon reading the above disclosure. Therefore, the protection scope of the present invention should be defined by the appended claims.
Claims (10)
Translated fromChinese
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110327128.5ACN102500055B (en) | 2011-10-25 | 2011-10-25 | Non-absorbable suture-assisted implantable flexible microelectrode and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110327128.5ACN102500055B (en) | 2011-10-25 | 2011-10-25 | Non-absorbable suture-assisted implantable flexible microelectrode and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102500055Atrue CN102500055A (en) | 2012-06-20 |
| CN102500055B CN102500055B (en) | 2014-02-26 |
Family
ID=46212227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110327128.5AExpired - Fee RelatedCN102500055B (en) | 2011-10-25 | 2011-10-25 | Non-absorbable suture-assisted implantable flexible microelectrode and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102500055B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103767704A (en)* | 2014-01-20 | 2014-05-07 | 上海交通大学 | Quasi-dry electrode used for electroencephalogram measurement and preparation method thereof |
| EP2862595A1 (en)* | 2013-10-21 | 2015-04-22 | NeuroNexus Technologies, Inc. | Omnidirectional deployable multichannel neural electrode system |
| CN105641805B (en)* | 2014-10-28 | 2017-11-28 | 常州瑞神安医疗器械有限公司 | Embedded nerve stimulator electrode contacts structure |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5241957A (en)* | 1991-11-18 | 1993-09-07 | Medtronic, Inc. | Bipolar temporary pacing lead and connector and permanent bipolar nerve wire |
| EP0815897A2 (en)* | 1996-06-28 | 1998-01-07 | Medtronic, Inc. | Temporary bipolar heart wire |
| CN101138663A (en)* | 2007-10-25 | 2008-03-12 | 上海交通大学 | Fabrication method of biological microelectrode array based on flexible substrate |
| CN101785904A (en)* | 2010-01-14 | 2010-07-28 | 上海交通大学 | Method for preparing metal wire biological microelectrode |
| CN102151358A (en)* | 2011-04-29 | 2011-08-17 | 上海交通大学 | Removable denture-style flexible microelectrodes for facial paralysis rehabilitation |
- 2011
- 2011-10-25CNCN201110327128.5Apatent/CN102500055B/ennot_activeExpired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5241957A (en)* | 1991-11-18 | 1993-09-07 | Medtronic, Inc. | Bipolar temporary pacing lead and connector and permanent bipolar nerve wire |
| EP0815897A2 (en)* | 1996-06-28 | 1998-01-07 | Medtronic, Inc. | Temporary bipolar heart wire |
| CN101138663A (en)* | 2007-10-25 | 2008-03-12 | 上海交通大学 | Fabrication method of biological microelectrode array based on flexible substrate |
| CN101785904A (en)* | 2010-01-14 | 2010-07-28 | 上海交通大学 | Method for preparing metal wire biological microelectrode |
| CN102151358A (en)* | 2011-04-29 | 2011-08-17 | 上海交通大学 | Removable denture-style flexible microelectrodes for facial paralysis rehabilitation |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2862595A1 (en)* | 2013-10-21 | 2015-04-22 | NeuroNexus Technologies, Inc. | Omnidirectional deployable multichannel neural electrode system |
| EP3254726A1 (en)* | 2013-10-21 | 2017-12-13 | NeuroNexus Technologies, Inc. | Omnidirectional deployable multichannel neural electrode system |
| US10118030B2 (en) | 2013-10-21 | 2018-11-06 | Neuronexus Technologies, Inc. | Omnidirectional deployable multichannel neural electrode system |
| US10173051B2 (en) | 2013-10-21 | 2019-01-08 | Neuronexus Technologies, Inc. | Neural electrode system with a carrier having a tape spring-type shape |
| US10842991B2 (en) | 2013-10-21 | 2020-11-24 | Neuronexus Technologies, Inc. | Neural electrode system with a carrier having a tape spring-type shape |
| CN103767704A (en)* | 2014-01-20 | 2014-05-07 | 上海交通大学 | Quasi-dry electrode used for electroencephalogram measurement and preparation method thereof |
| CN103767704B (en)* | 2014-01-20 | 2015-08-26 | 上海交通大学 | Dry electrode of a kind of standard for EEG measuring and preparation method thereof |
| CN105641805B (en)* | 2014-10-28 | 2017-11-28 | 常州瑞神安医疗器械有限公司 | Embedded nerve stimulator electrode contacts structure |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102500055B (en) | 2014-02-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Huang et al. | Bioelectronics for electrical stimulation: materials, devices and biomedical applications | |
| Decataldo et al. | Stretchable low impedance electrodes for bioelectronic recording from small peripheral nerves | |
| Paggi et al. | Compliant peripheral nerve interfaces | |
| AU2018279871A1 (en) | Electrode cured and manufactured in the body, and related methods and devices | |
| US7725198B2 (en) | Implantable medical lead assemblies with delivery tether | |
| Yu et al. | A parylene self-locking cuff electrode for peripheral nerve stimulation and recording | |
| US7898156B2 (en) | Muscle-driven nanogenerators | |
| US20100168831A1 (en) | Implantable clip-on micro-cuff electrode for functional stimulation and bio-potential recording | |
| Byun et al. | Fabrication of a flexible penetrating microelectrode array for use on curved surfaces of neural tissues | |
| CN104306066A (en) | Rat leg motion reconstruction test method based on spinal nerve function electrical stimulation | |
| CN102500055B (en) | Non-absorbable suture-assisted implantable flexible microelectrode and preparation method thereof | |
| CN103768713A (en) | Paralyzed limb movement control method based on acupuncture point functional electrical stimulation | |
| RU2012124937A (en) | METHOD FOR PAINLESS OR CLOSE TO PAINLESS INJECTION AND DEVICE FOR ITS IMPLEMENTATION (OPTIONS) | |
| Li et al. | Flexible and stretchable implantable devices for peripheral neuromuscular electrophysiology | |
| Seo et al. | Nerve cuff electrode using embedded magnets and its application to hypoglossal nerve stimulation | |
| CN102500056B (en) | Auxiliary-implanted flexible microelectrode for absorbable suture and preparation method thereof | |
| CN101785904B (en) | Method for preparing metal wire biological microelectrode | |
| Zhang et al. | Bipolar Concentric Ring Microneedle Array (BCRMA): An Electrical Stimulation Electrode for Precise Movement Control | |
| CN102151358B (en) | Movable false tooth type flexible microelectrode applicable to facial paralysis rehabilitation | |
| Korivi et al. | Clip-on micro-cuff electrode for neural stimulation and recording | |
| CN101870452B (en) | Preparation method of MEMS wire biological microelectrode | |
| CN215608813U (en) | A one-time low-frequency electrical stimulation therapeutic needle | |
| US20230098646A1 (en) | Neuromodulation devices and related methods | |
| CN116808313B (en) | Preparation method of a self-powered silk fibroin denervated muscle electrical stimulation scaffold | |
| Liu et al. | NeuroWorm: a Long-term Implantable Soft Microfibre for Multimodal Biosensing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee | Granted publication date:20140226 Termination date:20171025 |