Movatterモバイル変換


[0]ホーム

URL:


CN102488578B - Quick blood flow reconstruction device and preparation method thereof - Google Patents

Quick blood flow reconstruction device and preparation method thereof
Download PDF

Info

Publication number
CN102488578B
CN102488578BCN201110416746.7ACN201110416746ACN102488578BCN 102488578 BCN102488578 BCN 102488578BCN 201110416746 ACN201110416746 ACN 201110416746ACN 102488578 BCN102488578 BCN 102488578B
Authority
CN
China
Prior art keywords
far
diameter
silk
length
outer tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201110416746.7A
Other languages
Chinese (zh)
Other versions
CN102488578A (en
Inventor
姜卫剑
成正辉
匡华
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HUNNA RUIKANGTONG TECHNOLOGY DEVELOPMENT Co Ltd
Original Assignee
HUNNA RUIKANGTONG TECHNOLOGY DEVELOPMENT Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HUNNA RUIKANGTONG TECHNOLOGY DEVELOPMENT Co LtdfiledCriticalHUNNA RUIKANGTONG TECHNOLOGY DEVELOPMENT Co Ltd
Priority to CN201110416746.7ApriorityCriticalpatent/CN102488578B/en
Publication of CN102488578ApublicationCriticalpatent/CN102488578A/en
Application grantedgrantedCritical
Publication of CN102488578BpublicationCriticalpatent/CN102488578B/en
Activelegal-statusCriticalCurrent
Anticipated expirationlegal-statusCritical

Links

Landscapes

Abstract

The invention discloses a quick blood flow reconstruction device and a preparation method thereof, and aims to solve the technical problem to quickly realize blood vessel reperfusion and blood flow reconstruction. The quick blood flow reconstruction device is provided with a guide wire; the far end of the guide wire is provided with a meshy sacculus; the meshy sacculus is cylindrical in a release state; two ends of the meshy sacculus have constricted meshy structures; the axis of the meshy sacculus is in slide contact with the guide wire; and a stopper is arranged in the meshy sacculus and on a core wire at the far end. The preparation method for the quick blood flow reconstruction device comprises the following steps of: preparing the guide wire with the meshy sacculus; conveying an outer tube of a recovery conduit; and conveying an inner tube of the recovery conduit. Compared with the prior art, the invention has the advantages that: the quick blood flow reconstruction device is firmly arranged on a lesion part of a totally occluded blood vessel through the meshy sacculus, blood flow can be instantly restored in a small flow rate, the guide wire with the meshy sacculus is put on a thrombus part of the blood vessel for 45 to 120 minutes, and the blood vessel can be completely restored; and the two ends of the meshy sacculus have the enclosed meshy structures to protect the near end and the far end of the blood vessel, and new embolism at the near end or the far end is prevented.

Description

Quick blood flow reconstruction device and preparation method thereof
Technical field
The present invention relates to a kind of medical surgical instrument and preparation method thereof, particularly a kind of apparatus for interventional therapy full cut-off plug angiopathy and preparation method thereof.
Background information
Blood of human body solidify or blood in some visible component sticky collection mutually, form solid matter piece vascular occlusion, be a kind of vascular lesion that carries out slowly, mainly involves small artery and vein in extremity.Pathological change is stage, the nonsuppurative inflammation companion intracavity thrombosis of blood vessel wall, and tube chamber blocks, and causes limb ischemia.
Generally adopt clinically and treat in two ways vascular occlusion: medicine thrombolytic and machinery are got bolt.Heparin is main anticoagulant, can effectively prevent and treat deep venous thrombosis of lower limbs, is widely used in recent years unstable angina pectoris, finally the wait indefinitely treatment of disease of acute myocardial infarction and brain.But heparin has shortcomings, as easily hemorrhage, must carry out the monitoring of laboratory clotting mechanism, use inconvenience, and can bring out thrombocytopenia and aleucia.EV3 Company that only having of can be applicable at present that Intravascular Thrombus takes out just ratified by the FDA of FDA (Food and Drug Adminstration) produces gets bolt device Concentric Retriever.The smooth rate of the revascularization of this utensil after clinical use is 55.6%~60%, is that the machinery that is applied in the world at present to treat blood vessel embolism is got pin device.The principle that this device is used is: at lesion vessels near-end, utilize the supply of interim filling air bag blocking-up blood vessel, wrap up thrombosis, and it is drawn in to conduit cavity in blood vessel with turn, eliminate the interim filling air bag of blood vessel, then exit conduit.This utensil is only provided with nearly segment protect device, and its spiral spring circle, in removal of thromboses process, easily causes thrombosis to be broken into fragment, causes blood vessel far-end by thromboembolism, and operation process needs blocking blood flow, may cause distal vessels blood supply insufficiency.
Summary of the invention
The object of this invention is to provide a kind of Quick blood flow reconstruction device and preparation method thereof, the technical problem that solve is to realize fast revascularization, rebuilds blood flow.
The present invention is by the following technical solutions: a kind of Quick blood flow reconstruction device, described Quick blood flow reconstruction device is provided with tennis seal wire, tennis seal wire is provided with seal wire, the far-end of seal wire is provided with netted sacculus, netted sacculus release conditions are cylindric, the network structure of two ends for shrinking, and its axis is coaxial with seal wire, netted sacculus and seal wire form sliding-contact, on far-end core silk, the inside of netted sacculus is provided with stop.
Seal wire of the present invention is connected with the near-end core silk that is positioned at near-end by the far-end core silk that is positioned at far-end, is equipped with fixedly NiTi pipe in junction, and seal wire free state is that linearity is thread.
The distal end of seal wire of the present invention is connected with conductive filament head.
Conductive filament head of the present invention adopts platinum wire, tungsten alloy or billon silk, stainless steel silk to turn to coil spring shape.
Indicating is equipped with at the two ends of netted sacculus of the present invention.
Tennis seal wire of the present invention is arranged on to carry and reclaims in conduit, forms sliding-contact with carrying recovery conduit.
Outer tube and the inner tube that conduit is provided with coaxial setting reclaimed in conveying of the present invention, and outer tube and inner tube form and be slidably connected.
The far-end outer rim of outer tube of the present invention is equipped with outer tube indicating, and proximal outer tube is connected with outer tube joint, and proximal outer tube and outer tube joint junction are equipped with outer tube strain relief sleeve pipe; Described outer tube is three-decker, and internal layer adopts politef, and intermediate layer is steel wire, helical spring or steel wire+helical spring; Outer nylon, nylon elastomer or the polyurethane of adopting.
The far-end outer rim dress inner tube indicating of inner tube of the present invention, inner tube near-end is connected with inner pipe joint, and inner tube near-end and inner pipe joint junction are equipped with inner tube strain relief sleeve pipe, and described inner tube is inside and outside two-layer, internal layer adopts politef, outer nylon, nylon elastomer or the polyurethane of adopting.
A kind of preparation method of Quick blood flow reconstruction device, comprise the following steps: one, prepare tennis seal wire, 1, braiding webmaster, adopt nitinol alloy wire, titanium silk, platinum wire, platinumiridio silk, stainless steel silk, diameter is 0.038mm~0.30mm, quantity is 8~48, braiding webmaster, and every foot of nodes having of webmaster is 10~72; 2, the far-end of grinding far-end core silk and proximal end are tapering transition section, adopt nitinol alloy wire, external diameter is 0.25~0.97mm, length is 500~3000mm, being ground to distal length is the taper that 90~140mm, proximal length are 20~30mm, technological parameter is: 2000 revs/min of rotating speeds, amount of feeding 3mm/s; Near-end core silk adopts and scribbles politef stainless steel silk, and external diameter is 0.25~0.97mm, and length is 2500~0mm, grinding near-end core silk far-end and near-end, the long 20~30mm of its far-end grinding taper, the long 30~40mm of near-end grinding taper; 3, netted sacculus is made, and woven webmaster is nested with on the netted sacculus mould cylindric, two ends are taper, in vacuum 10-3below handkerchief, from room temperature, with 10~20min time, be warming up to 450~550 ℃, be incubated 30 minutes, in stove, naturally cool to room temperature; Webmaster is taken off from netted sacculus mould, and the platinum, platinum alloy, gold, Nitinol or the rustless steel indicating that by the braided wires overcoat top external diameter at webmaster two ends, are 0.37~1.2mm, adopt brazing, 230 ± 30 ℃ of welding temperatures; 4, make conductive filament head spring: adopting platinum wire, tungsten alloy or billon silk, stainless steel silk that diameter is 0.05~0.25mm, is 0.20~0.97mm around causing external diameter, long 7~150mm, the conductive filament head spring that pitch is 0.06~0.26mm; 5, the assembling of tennis seal wire, netted sacculus one end is enclosed within to far-end core silk far-end, by material, be that rustless steel, external diameter are that the stop that 0.33~1.16mm, internal diameter are 0.2~1.0mm is nested with on far-end core silk, then the netted sacculus other end is enclosed within on far-end core silk, stop is weldingly fixed on far-end core silk to welding temperature: 230 ± 30 ℃; Distal end by conductive filament head spring housing at far-end core silk, is welded to connect conductive filament head spring, rustless steel flat filament and far-end core silk 5, and technological parameter is: electric current 80~100A, pulsewidth 4.0~6.0ms, frequency, 6~8HZ, weld interval 1~3s; Far-end core silk near-end and near-end core silk far-end are put in to fixedly NiTi pipe, with medical AB is gluing, connect or soldering is fixedly connected with three; Two, carry the making of reclaiming conduit outer tube, 1, outer pipe shaft is made, by inner layer material, wire of intermediate layer net, helical spring or steel wire+helical spring, cladding material is sequentially nested with on the plug of Nitinol, rustless steel or politef, is nested with upper exterior tube indicating near distal end, be nested with again fluorinated ethylene propylene (FEP) heat shrink films, technological parameter is: rheological temperature 380~450 ℉, and rheology speed 0.08~0.16cm/s, takes out plug and makes outer pipe shaft; 2, joint is bonding, on the far-end contact surface of proximal outer tube outer rim and joint, smears ultraviolet cured adhesive, and the near-end of outer tube is put in to rigging position from the remote stomidium of joint, with purple light machine, irradiates and is solidified; At the outer tube pipe shaft near joint, be nested with strain relief sleeve pipe outward, with hot-air blower, strain relief sleeve pipe tightened up to the remote location at joint; Three, carry the making of reclaiming conduit inner tube, inner tube two-layerly consists of inside and outside, by inner layer material, cladding material is nested with on the plug of Nitinol, rustless steel or politef, near distal end, cover is set up inner tube indicating, then is nested with fluorinated ethylene propylene (FEP) heat shrink films, and technological parameter is: rheological temperature 380~450 ℉, rheology speed 0.08~0.16cm/s, takes out plug and makes interior pipe shaft.
The present invention compared with prior art; utilize netted sacculus to be firmly placed in full cut-off plug vascular lesion position; blood flow can recover at moment low discharge; tennis seal wire was continued to be placed on vascular thrombosis place after 45~120 minutes; blood flow can recover completely, and netted sacculus two ends are the network structure of sealing, to the near-end of blood vessel and far-end, provide protection; the issuable thrombosis fragment of operation process is fallen in netted sacculus and is hunted down, and avoids forming near-end or the new thromboembolism of distal site.
Accompanying drawing explanation
Fig. 1 is the tennis guide wire schematic diagram of the embodiment of the present invention.
Fig. 2 is the outer tube structure figure that conduit is reclaimed in the conveying of the embodiment of the present invention.
Fig. 3 is the inner tube structure figure that conduit is reclaimed in the conveying of the embodiment of the present invention.
Fig. 4 is lesion vessels schematic diagram before treatment.
Fig. 5 is Quick blood flow reconstruction device course of conveying schematic diagram of the present invention ().
Fig. 6 is Quick blood flow reconstruction device course of conveying schematic diagram of the present invention (two).
Fig. 7 is Quick blood flow reconstruction device course of conveying schematic diagram of the present invention (three).
Fig. 8 is Quick blood flow reconstruction device course of conveying schematic diagram of the present invention (four).
Fig. 9 is that Quick blood flow reconstruction device of the present invention discharges complete schematic diagram.
Figure 10 is Quick blood flow reconstruction device therapeutic process schematic diagram of the present invention.
Figure 11 is that Quick blood flow reconstruction device of the present invention has been treated schematic diagram.
Figure 12 is webmaster schematic diagram of the present invention.
Figure 13 is schematic diagram after netted sacculus molding of the present invention.
Figure 14 is netted sacculus mould schematic diagram of the present invention.
The specific embodiment
Below in conjunction with drawings and Examples, the present invention is described in further details.Each sequence number is expressed as in the accompanying drawings: 1 is conductive filament head, and 2 is stop, and 3 is netted sacculus, 4 for indicating, and 5 be far-end core silk, and 6 is fixing NiTi pipe, 7 is near-end core silk, and 8 is outer tube indicating, and 9 is outer tube, 10 is inner tube indicating, 11 is inner tube, and 12 is outer tube joint, and 13 is outer tube strain relief sleeve pipe, 14 is inner pipe joint, and 15 is inner tube strain relief sleeve pipe.
Quick blood flow reconstruction device of the present invention, is provided with tennis seal wire, and tennis seal wire is arranged on to carry and reclaims in conduit, and can in carrying recovery conduit, slide, and reclaims conduit form sliding-contact with conveying.
As shown in Figure 1, tennis seal wire is provided with the thread far-end core silk that is positioned at far-end 5 and is positioned at the near-end core silk 7 of near-end, the near-end of far-end core silk 5 is connected with the far-end of near-end core silk 7, junction is equipped with fixedly NiTi pipe 6, far-end core silk 5, near-end core silk 7 and the seal wire that fixedly NiTi pipe 6 formation free states are linearity.The distal end of far-end core silk 5 is connected with soft conductive filament head 1, and near-end one side of conductive filament head 1 is provided with netted sacculus 3.Netted sacculus 3 release conditions are cylindric, the network structure of two ends for shrinking, and its axis is coaxial with seal wire, and netted sacculus 3 can radially shrink, and forms sliding-contact with the far-end core silk 5 of seal wire, can on far-end core silk 5, slide.On far-end core silk 5, the inside of netted sacculus 3 is provided with stop 2, the position of sliding along far-end core silk 5 for limiting netted sacculus 3.Indicating 4 is equipped with at the two ends of netted sacculus 3, for X ray, monitors the lower position that shows woven mesh sacculus 3.
It is that braided wires braiding forms that netted sacculus 3 adopts memory alloy wire nitinol alloy wire, titanium silk, platinum wire, platinumiridio silk, stainless steel silk, braided wires diameter is 0.038~0.30mm, quantity is 8~48, and every foot of nodes PPI having (Point per inch) is 10-72.Netted sacculus 3 is assemblied on far-end core silk 5, and the maximum outside diameter after netted sacculus 3 discharges is completely 3~30mm.For ease of can see the netted sacculus 3 opening under X-ray, can be at the upper gold-plated or platinum alloy of netted sacculus 3, also can when establishment, enroll the composite of more than two platinum wire, spun gold, tungsten filament, tantalum wire, NITI silk and platinum or NITI and golden composite.
Conductive filament head 1 adopts platinum wire, tungsten alloy or billon silk, the stainless steel silk that diameter is 0.05~0.25mm to turn to coil spring shape, and its external diameter is 0.20~0.97mm, long 7~150mm.
Indicating 4 external diameters at netted sacculus 3 two ends are 0.37~1.2mm, adopt platinum, platinum alloy, gold, Nitinol or rustless steel, by welding, are connected with netted sacculus 3.
Far-end core silk 5 adopts nitinol alloy wire, and string diameter is 0.25~0.97mm, and length is 500~3000mm.Far-end core silk 5 distal ends are tapering transition section, for being connected with conductive filament head 1.
Near-end core silk 7 adopts the stainless steel silk that scribbles polytetrafluoroethylene PTFE, and string diameter is 0.25~0.97mm, and length is 2500~0mm, and seal wire overall length is 3000mm, if far-end core silk is 3000mm, near-end core silk is 0.
Fixedly NiTi pipe 6 external diameters are 0.33~0.97mm, and internal diameter is 0.25~0.89mm, and length is 40mm.Far-end core silk 5 adopts the fixedly NiTi pipe 6 of Nitinol to be nested with near-end core silk 7 junctions and connects as one.
After netted sacculus 3 is retracted, can be arranged on to carry and reclaim in conduit, can in carrying recovery conduit, slide.Carry and reclaim outer tube 9 and the inner tube 11 that conduit is provided with coaxial setting, outer tube 9 and inner tube 11 form and are slidably connected.Netted sacculus 3 is contracted in the interior slip of inner tube 11.
As shown in Figure 2, outer tube 9 is for tennis seal wire is transported to target location, and operation withdrawn from after finishing externally, and its internal diameter is 0.61~2.1mm, and external diameter is 0.81~2.5mm, long 140~150mm.The far-end outer rim of outer tube 9 is equipped with the outer tube indicating 8 that can develop under X ray, and outer tube indicating 8 external diameters are 0.71~2.2mm, adopts platinum, platinum alloy, gold, Nitinol or rustless steel, by the mode of welding, is connected with outer tube 9.Outer tube 9 near-ends are connected with outer tube joint 12, and outer tube 9 near-ends and outer tube joint 12 junctions are equipped with outer tube strain relief sleeve pipe 13.
Outer tube 9 is three-decker, and internal layer adopts polytetrafluoroethylene PTFE, and during use, endoporus can obtain less frictional resistance, and intermediate layer is steel wire, helical spring or steel wire+helical spring.Rustless steel, tungsten or the NITI silk of diameter 0.01~0.06mm for steel wire, PPI is 30~120.Steel wire is in order to guarantee to carry the thrust that reclaims conduit outer tube 9, helical spring is made with rustless steel, tungsten filament or the NITI filament winding of diameter 0.01~0.07mm, pitch is 0.012~0.1mm, external diameter is 0.71~2.2mm, helical spring guarantees to carry the fracture resistance that reclaims conduit outer tube 9, also can increase X-ray visuality.Nylon elastomer or the polyurethane PU of outer employing nylon, U.S. pebax are material.
As shown in Figure 3, inner tube 11 is placed in outer tube, strengthens outer tube enabling capabilities, for help outer tube intravasation and in blood vessel smooth and easy delivery guidewire, its internal diameter is 0.43~1.82mm, external diameter is 0.60~2.0mm, length is 160~170mm.The far-end outer rim of inner tube 11 is equipped with the inner tube indicating 10 that can develop under X ray, and inner tube indicating 10 adopts platinum, platinum alloy, gold, Nitinol or rustless steel, by welding, is connected with inner tube 11.Inner tube 11 near-ends are connected with inner pipe joint 14, and inner tube 11 near-ends and inner pipe joint 14 junctions are equipped with inner tube strain relief sleeve pipe 15.
Inner tube 11 is inside and outside two-layer, and internal layer adopts polytetrafluoroethylene PTFE, and nylon elastomer or the polyurethane PU of outer employing nylon, U.S. pebax are material.
The outer segmentation of the skin of outer tube 9 and inner tube 11 adopts the polymeric material of different hardness, the hardness that makes carry to reclaim conduit vertically by near-end to far-end classification deliquescing gradually, near-end has good propelling movement and twisting property, far-end is softer, pliability is good, can in complicated cardiovascular and cerebrovascular vessel, freely carry, avoid injured blood vessel.
As shown in Figure 4, the thrombi 17 in blood vessel 16 causes inaccessible section at thromboembolism position, and occluding vascular 16, is obstructed the blood flow 18 in blood vessel 16.
As shown in Figure 5, when using Quick blood flow reconstruction device of the present invention, carry the outer tube 9 that reclaims conduit and the inner tube 11 in it to be delivered along the guiding seal wire of operation use the inaccessible section causing by thrombi 17, surpass inaccessible section far-end 4mm to outer tube indicating 8.Withdraw from guiding seal wire and inner tube 11, through loader, tennis seal wire is sent into and carried in the outer tube 9 that reclaims conduit, under monitoring, X ray slowly to far-end, pushes, as shown in Figure 6, until the conductive filament head 1 of tennis seal wire approaches indicating 8, netted sacculus 3 far-ends are through inaccessible section, as shown in Figure 7, outer tube and tennis seal wire are adjusted to its position as a whole, and extremely netted sacculus 3 far-end indicatings 4 surpass plug segment 10~15mm.As shown in Figure 8, keep tennis seal wire invariant position, withdraw outer tube 9, until netted sacculus 3 is all released from outer tube 9 far-ends.As shown in Figure 9, now netted sacculus 3 is opened naturally, runs through whole thrombi 17 positions from thrombi 17; netted sacculus 3 two ends are released and are filled to blood vessel 16 tube walls; blood vessel 16 to thrombi 17 near-ends and far-end forms protection, and blood flow at once part is rebuilt, but flow is very little.Conveying and the dispose procedure of tennis seal wire complete.
As shown in figure 10, continue to place tennis seal wire in blood vessel 45~120 minutes, in blood circulation process, pass through autolysis, thrombi is slowly dissolved, until blood vessel recovers blood flow completely, during issuable thrombosis fragment via netted ball keed hole, fall in netted sacculus 3 and caught by it.As shown in figure 11, keep the invariant position of tennis seal wire, toward far-end, advance outer tube 9, until netted sacculus 3 all enters in outer tube 9, outer tube 9 and interior tennis seal wire thereof are withdrawn from as a whole external, complete whole operation process.
The preparation method of Quick blood flow reconstruction device of the present invention, comprises the following steps:
One, prepare tennis seal wire
1, braiding webmaster, adopts nitinol alloy wire, titanium silk, platinum wire, platinumiridio silk, stainless steel silk, and diameter is 0.038mm~0.30mm, and quantity is 8~48, braiding webmaster, and every foot of nodes PPI having of webmaster is 10~72.As shown in figure 12, best is with 16 diameter 0.071mm nitinol alloy wires, on the HTBZ-40 type braider of manufacturing, weaves webmaster in Shenzhen Huitai Medical Instrument Co., Ltd, and PPI is 16.
2, the far-end of grinding far-end core silk and proximal end are tapering transition section, adopt nitinol alloy wire, and external diameter is 0.25~0.97mm, and length is 500~3000mm.Best for adopting the nitinol alloy wire of diameter 0.36mm, after blanking, on the TG12X4 type cylindrical grinder that the far-end of silk and near-end are manufactured in U.S. ROYAL MASTER GEINDERS.INC company, being ground to distal length is the taper that 90~140mm, proximal length are 20~30mm, technological parameter is: 2000 revs/min of rotating speeds, amount of feeding 3mm/s.Near-end core silk adopts and scribbles polytetrafluoroethylene PTFE stainless steel silk, external diameter is 0.25~0.97mm, length is 2500~0mm, seal wire overall length is 3000mm, if far-end core silk is 3000mm, near-end core silk is 0, grinding near-end core silk far-end and near-end, processing method is identical with grinding far-end core silk with parameter, the long 20~30mm of its far-end grinding taper, the long 30~40mm of near-end grinding taper.
3, netted sacculus is made, and woven webmaster is nested with on netted sacculus mould, and as shown in figure 14, netted sacculus mould is cylindric, and two ends are taper.Webmaster after dress mould is put into the ZSK2-12-6 type vacuum heat treatment furnace heat treatment shaping that Wuhan industrial furnace factory manufactures, in vacuum 10-3below handkerchief, from room temperature, with 10~20min time, be warming up to 450~550 ℃, be incubated 30 minutes, in stove, naturally cool to room temperature.After thermoforming, webmaster is taken off from netted sacculus mould, the platinum, platinum alloy, gold, Nitinol or the rustless steel indicating that by the braided wires overcoat top external diameter at webmaster two ends, are 0.37~1.2mm, the best is platinum indicating, adopt brazing, 230 ± 30 ℃ of welding temperatures, as shown in figure 13, make complete netted sacculus.
4, make conductive filament head spring: adopt platinum wire, tungsten alloy or billon silk, stainless steel silk that diameter is 0.05~0.25mm, on the L80 type precision spring curling machine of producing in U.S. Roth Greaves & Associates.Inc company, around causing external diameter, be 0.20~0.97mm, long 7~150mm, the conductive filament head spring that pitch is 0.06~0.26mm.
5, the assembling of tennis seal wire, netted sacculus 3 one end are enclosed within to far-end core silk 5 far-ends, from this position, by material, be that medical grade rustless steel, external diameter are that the opening stop 2 that 0.33~1.16mm, internal diameter are 0.2~1.0mm is nested with on far-end core silk 5 again, (far-end core silk 5 is nested with the position of stop 5 first through partly processing, size is less than raw material diameter), then netted sacculus 3 other ends are enclosed within on far-end core silk 5, adopt soldering that stop 2 is weldingly fixed on far-end core silk 5, welding temperature: 230 ± 30 ℃.After welded limiting device 2, in conductive filament head spring, insert the rustless steel flat filament of one 0.002 " * 0.006 ", for increasing conductive filament head tensile strength, the distal end by conductive filament head spring housing at far-end core silk 5, the JHM-1GY-110H type laser-beam welding machine of manufacturing with Wuhan sky above Hubei and Hunan industrial lasers equipment company limited, conductive filament head spring, rustless steel flat filament and far-end core silk 5 are welded to connect, technological parameter is: electric current 80~100A, pulsewidth 4.0~6.0ms, frequency, 6~8HZ, weld interval 1~3s.Finally far-end core silk near-end and near-end core silk far-end are put in to fixedly NiTi pipe 6, with medical AB is gluing, connect or brazing mode is fixedly connected with three, the welding of soldering processes stop is identical, AB is gluing while connecing, glue is evenly spread upon to far-end core silk near-end and near-end core silk far-end connecting portion surface, again far-end core silk near-end and near-end core silk far-end are put in to fixedly NiTi pipe 6, wipe unnecessary AB glue, place that the glue solidifies in 24 hours.Fixedly NiTi pipe 6 external diameters are 0.33~0.97mm, and internal diameter is 0.25~0.89mm, and length is 40mm.
Two, carry the making of reclaiming conduit outer tube
1, outer pipe shaft is made
By inner layer material, wire of intermediate layer net, helical spring or steel wire+helical spring, outer high molecular polymer is sequentially nested with on the plug of Nitinol, rustless steel or politef, near distal end, be nested with upper exterior tube indicating, be nested with fluorinated ethylene propylene (FEP) FEP heat shrink films, internal layer, intermediate layer and skin fuse together again, and take out plug and make outer pipe shaft, technological parameter is: rheological temperature 380~450 ℉, rheology speed 0.08~0.16cm/s.The internal diameter of outer tube is 0.61~2.1mm, and external diameter is 0.81~2.5mm, and length is 140~150cm.
Inner layer material is politef, and internal diameter is 0.61~2.1mm, and wall thickness is 0.025~0.06mm, and length is 140~150cm.
8~32 of the rustless steel of diameter 0.01~0.06mm for steel wire, tungsten filament or NITI silks, PPI is 30~120, on the braider of Grand Technology's customization, weaves.
Helical spring forms with the L80 model precision spring curling machine coiling of rustless steel, tungsten filament or the manufacture of NITI Si U.S. RothGreaves & Associates.Inc company of diameter 0.01~0.07mm, pitch is 0.012~0.1mm, and external diameter is 0.71~2.2mm.
Outer high molecular polymer, internal diameter is 0.81~2.5mm, external diameter is 1.0~2.7mm, length is 140~150cm, is Pebax, nylon, material from near-end to far-end hardness gradually classification reduce, be respectively 72D, 63D, 55D, 40D.
Outer tube indicating external diameter is 0.71~2.2mmm, and wall thickness is 0.025~0.05mm, and length is that 0.8~1.5mm material is platinum, platinum alloy, gold, Nitinol or rustless steel.
2, joint is bonding
With the KH228 type point gum machine that U.S. MORCSONDFO.INC produces, on the far-end contact surface of proximal outer tube outer rim and joint, smear the uniform ultraviolet cured adhesive UV of one deck glue, the near-end of outer tube is put in to rigging position from the remote stomidium of joint, and the DYMAX type purple light machine of then producing with Shenzhen special light units factory irradiates and is solidified.At the outer tube pipe shaft near joint, be nested with strain relief sleeve pipe outward, with hot-air blower, strain relief sleeve pipe tightened up to the remote location at joint.
Joint adopts Merlon, internal diameter 4.1mm.
Strain relief sleeve pipe adopts polyolefin, and internal diameter is 3.0mm.
Three, carry the making of reclaiming conduit inner tube
Inner tube two-layerly consists of inside and outside, and its processing technique equipment parameter and outer tube processing technique equipment, parameter are identical.
Inner tube diameter is 0.43~1.82mm, and external diameter is 0.60~2.0mm, and length is 160~170mm.
Inner layer material politef, internal diameter is 0.43~1.82mm, and wall thickness is 0.025~0.06mm, and length is 160~170cm.
Outer high molecular polymer, internal diameter is 0.61~2.0mm, and external diameter is 0.81~2.2mm, and length is 160~170cm, for nylon, the nylon elastomer of U.S. pebax, polyurethane PU, material from near-end to far-end hardness gradually classification reduce, as pebax is respectively 72D, 63D, 55D, 40D.
Inner tube indicating internal diameter is 0.51~1.9mm, and wall thickness is 0.025~0.05mm, and length is 0.8~1.5mm, and material is platinum, platinum alloy, gold, Nitinol or rustless steel.
Embodiment 1, and netted sacculus adopts the braiding of memory alloy wire nitinol alloy wire to form, and braided wires diameter is 0.071mm, quantity is 16, every foot of nodes having is 16, and the maximum outside diameter after netted sacculus discharges is completely 4.5mm, and far-end core silk, near-end core filament diameter are 0.36mm.Outer tube external diameter is 0.99mm, and internal diameter is 0.71mm.
Animal experiment, selects one of 20 kilograms of test beasle dog of body weight, in this dog body, has obvious vascular occlusion, and the Quick blood flow reconstruction device of embodiment 1 and accessory thereof (carry and reclaim conduit inner and outer tubes, loader) are a set of.Through femoral artery, puncture, under angiography, confirm behind thromboembolism position, under X ray monitors, first send into seal wire, by the guiding function of seal wire, will carry and reclaim catheter propelling to default position.The far-end indicating of reclaiming conduit outer tube by conveying judges that whether its position is suitable, observes and carry the indicating of recovery conduit distal outer tube to cross thromboembolism position arrival blood vessel far-end under X ray.Fixing conveying reclaimed conduit outer tube, seal wire is withdrawn from external with carrying recovery conduit inner tube, by loader, tennis seal wire is packed in delivery conduit outer tube and toward far-end and advanced, indicating to netted sacculus far-end strides across thromboembolism position, keep tennis seal wire invariant position, withdraw and carry to reclaim conduit outer tube, due to the indicating at its netted sacculus two ends visuality under X ray, the netted sacculus of observing tennis seal wire under digital subtraction angiography DSA develops is released completely.Lasting placement is installed in blood vessel 45~120 minutes, row angiography observe the blood flow patency at this place good after, conveyings reclaimed to conduit outer tube and to far-end, advances, until netted sacculus is taken in outer tube completely under X ray supervision.By tennis seal wire with carry to reclaim conduit outer tube and withdraw from together with as a whole externally, complete this operation process.The blood flow state of observing vascular occlusion place with blood vessel interimage, occluding vascular is unobstructed, restoration of blood flow, and stop up without distal vessels.This operation process required time is short, operation safety, and success rate is high, to doctor's operating technology, requires relatively low.

Claims (2)

The far-end outer rim of described outer tube (9) is equipped with outer tube indicating (8), outer tube (9) near-end is connected with outer tube joint (12), and outer tube (9) near-end and outer tube joint (12) junction are equipped with outer tube strain relief sleeve pipe (13); Described outer tube (9) is three-decker, and internal layer adopts politef, and internal diameter is 0.61~2.1mm, and wall thickness is 0.025~0.06mm, and length is 140~150cm, and intermediate layer is steel wire, helical spring or steel wire+helical spring; 8~32 of the rustless steel of described steel wire diameter 0.01~0.06mm, tungsten filament or NITI silks, PPI 30~120 works out; The rustless steel of helical spring diameter 0.01~0.07, tungsten filament or NITI silk are made, and pitch is 0.012~0.1mm, and external diameter is 0.71~2.2mm; Outer nylon, nylon elastomer or the polyurethane of adopting, internal diameter is 0.81~2.5mm, external diameter is 1.0~2.7mm, and length is 140~150cm, and the internal diameter of described outer tube is 0.61~2.1mm, external diameter is 0.81~2.5mm, length is 140~150cm, and outer tube indicating external diameter is 0.71~2.2mm, wall thickness 0.025~0.05mm, length is 0.8~1.5mm, and material is platinum, platinum alloy, gold, Nitinol or rustless steel;
The far-end outer rim dress inner tube indicating (10) of described inner tube (11), inner tube (11) near-end is connected with inner pipe joint (14), inner tube (11) near-end and inner pipe joint (14) junction are equipped with inner tube strain relief sleeve pipe (15), described inner tube (11) is inside and outside two-layer, internal layer adopts politef, internal diameter is 0.43~1.82mm, and wall thickness is 0.025~0.06mm, and length is 160~170cm; Outer nylon, nylon elastomer or the polyurethane of adopting, internal diameter is 0.61~2.0mm, and external diameter is 0.81~2.2mm, and length is 160~170cm; Inner tube diameter is 0.43~1.82mm, and external diameter is 0.60~2.0mm, and length is 160~170mm; Inner tube indicating internal diameter is 0.51~1.9mm, and wall thickness is 0.025~0.05mm, and length is 0.8~1.5mm, and material is platinum, platinum alloy, gold, Nitinol or rustless steel;
2. the preparation method of a Quick blood flow reconstruction device, comprise the following steps: one, prepare tennis seal wire, 1, braiding webmaster, adopt nitinol alloy wire, titanium silk, platinum wire, platinumiridio silk, stainless steel silk, diameter is 0.071mm, and quantity is 16, braiding webmaster, every foot of nodes PPI having of webmaster is 16, on the HTBZ-40 type braider of manufacturing, weaves webmaster in Shenzhen Huitai Medical Instrument Co., Ltd, 2, far-end and the proximal end of grinding far-end core silk are tapering transition section, adopt nitinol alloy wire, external diameter is the nitinol alloy wire of 0.36mm, length is 500~3000mm, after blanking, on the TG12X4 type cylindrical grinder that the far-end of silk and near-end are manufactured in U.S. ROYALMASTER GEINDERS.INC company, being ground to distal length is 90~140mm, proximal length is the taper of 20~30mm, technological parameter is: 2000 revs/min of rotating speeds, amount of feeding 3mm/s, near-end core silk adopts and scribbles polytetrafluoroethylene PTFE stainless steel silk, external diameter is 0.25~0.97mm, length is 2500~0mm, seal wire overall length is 3000mm, grinding near-end core silk far-end and near-end, processing method is identical with grinding far-end core silk with parameter, long 20~the 30mm of its far-end grinding taper, long 30~the 40mm of near-end grinding taper, 3, netted sacculus is made, woven webmaster is nested with on netted sacculus mould, and netted sacculus mould is cylindric, and two ends are taper, webmaster after dress mould is put into the ZSK2-12-6 type vacuum heat treatment furnace heat treatment shaping that Wuhan industrial furnace factory manufactures, in vacuum 10-3below handkerchief, from room temperature with 10~20min time, be warming up to 450~550 ℃, be incubated 30 minutes, in stove, naturally cool to room temperature, after thermoforming, webmaster is taken off from netted sacculus mould, the platinum indicating that is 0.37~1.2mm by the braided wires overcoat top external diameter at webmaster two ends, adopt brazing, 230 ± 30 ℃ of welding temperatures, make complete netted sacculus, 4, make conductive filament head spring: adopt platinum wire, tungsten alloy or billon silk, stainless steel silk that diameter is 0.05~0.25mm, on the L80 type precision spring curling machine of producing in U.S. Roth Greaves & Associates.Inc company, around causing external diameter, be 0.20~0.97mm, long 7~150mm, the conductive filament head spring that pitch is 0.06~0.26mm, 5, the assembling of tennis seal wire, netted sacculus (3) one end is enclosed within to far-end core silk (5) far-end, from this position, by material, be medical grade rustless steel again, external diameter is 0.33~1.16mm, internal diameter is that the stop (2) of 0.2~1.0mm is nested with on far-end core silk (5), then netted sacculus (3) other end is enclosed within on far-end core silk (5), adopt soldering that stop (2) is weldingly fixed on far-end core silk (5), welding temperature: 230 ± 30 ℃, after welded limiting device (2), in conductive filament head spring, insert the rustless steel flat filament of one 0.002 " * 0.006 ", distal end by conductive filament head spring housing at far-end core silk (5), the JHM-1GY-110H type laser-beam welding machine of manufacturing with Wuhan sky above Hubei and Hunan industrial lasers equipment company limited, by conductive filament head spring, rustless steel flat filament and far-end core silk (5) are welded to connect, technological parameter is: electric current 80~100A, pulsewidth 4.0~6.0ms, frequency, 6~8HZ, weld interval 1~3s, finally far-end core silk near-end and near-end core silk far-end are put in to fixedly NiTi pipe (6), with medical AB is gluing, connect or brazing mode is fixedly connected with three, the welding of soldering processes stop is identical, AB is gluing while connecing, glue is evenly spread upon to far-end core silk near-end and near-end core silk far-end connecting portion surface, again far-end core silk near-end and near-end core silk far-end are put in to fixedly NiTi pipe (6), wipe unnecessary AB glue, place that the glue solidifies in 24 hours, fixedly NiTi pipe (6) external diameter is 0.33~0.97mm, internal diameter is 0.25~0.89mm, length is 40mm,
Two, carry the making of reclaiming conduit outer tube, 1, outer pipe shaft is made, by inner layer material, wire of intermediate layer net, helical spring or steel wire+helical spring, outer high molecular polymer is sequentially nested with at Nitinol, on the plug of rustless steel or politef, near distal end, be nested with upper exterior tube indicating, be nested with again fluorinated ethylene propylene (FEP) FEP heat shrink films, internal layer, intermediate layer and skin fuse together, take out plug and make outer pipe shaft, technological parameter is: rheological temperature 380~450 ℉, rheology speed 0.08~0.16cm/s, the internal diameter of outer tube is 0.61~2.1mm, external diameter is 0.81~2.5mm, length is 140~150cm, inner layer material is politef, and internal diameter is 0.61~2.1mm, and wall thickness is 0.025~0.06mm, and length is 140~150cm, 8~32 of the rustless steel of diameter 0.01~0.06mm for steel wire, tungsten filament or NITI silks, PPI is 30~120, on the braider of Grand Technology's customization, weaves, helical spring forms with the L80 model precision spring curling machine coiling of rustless steel, tungsten filament or the manufacture of NITI Si U.S. Roth Greaves & Associates.Inc company of diameter 0.01~0.07mm, pitch is 0.012~0.1mm, and external diameter is 0.71~2.2mm, outer high molecular polymer, internal diameter is 0.81~2.5mm, external diameter is 1.0~2.7mm, length is 140~150cm, is Pebax, nylon, material from near-end to far-end hardness gradually classification reduce, be respectively 72D, 63D, 55D, 40D, outer tube indicating external diameter is 0.71~2.2mmm, and wall thickness is 0.025~0.05mm, and length is that 0.8~1.5mm material is platinum, platinum alloy, gold, Nitinol or rustless steel,
Three, carry the making of reclaiming conduit inner tube, inner tube two-layerly consists of inside and outside, by inner layer material, cladding material is nested with on the plug of Nitinol, rustless steel or politef, near distal end, cover is set up inner tube indicating, then is nested with fluorinated ethylene propylene (FEP) heat shrink films, and technological parameter is: rheological temperature 380~450 ℉, rheology speed 0.08~0.16cm/s, takes out plug and makes interior pipe shaft; Inner tube diameter is 0.43~1.82mm, and external diameter is 0.60~2.0mm, and length is 160~170mm; Inner layer material politef, internal diameter is 0.43~1.82mm, and wall thickness is 0.025~0.06mm, and length is 160~170cm; Outer high molecular polymer, internal diameter is 0.61~2.0mm, external diameter is 0.81~2.2mm, length is 160~170cm, is nylon, the nylon elastomer of U.S. pebax, polyurethane PU, material from near-end to far-end hardness gradually classification reduce; Inner tube indicating internal diameter is 0.51~1.9mm, and wall thickness is 0.025~0.05mm, and length is 0.8~1.5mm, and material is platinum, platinum alloy, gold, Nitinol or rustless steel.
CN201110416746.7A2011-12-142011-12-14Quick blood flow reconstruction device and preparation method thereofActiveCN102488578B (en)

Priority Applications (1)

Application NumberPriority DateFiling DateTitle
CN201110416746.7ACN102488578B (en)2011-12-142011-12-14Quick blood flow reconstruction device and preparation method thereof

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
CN201110416746.7ACN102488578B (en)2011-12-142011-12-14Quick blood flow reconstruction device and preparation method thereof

Publications (2)

Publication NumberPublication Date
CN102488578A CN102488578A (en)2012-06-13
CN102488578Btrue CN102488578B (en)2014-10-15

Family

ID=46180486

Family Applications (1)

Application NumberTitlePriority DateFiling Date
CN201110416746.7AActiveCN102488578B (en)2011-12-142011-12-14Quick blood flow reconstruction device and preparation method thereof

Country Status (1)

CountryLink
CN (1)CN102488578B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US20160151145A1 (en)*2013-06-162016-06-02Pi-Cardia Ltd.Percutaneous emboli protection sleeve
CN106573130B (en)*2014-09-042020-01-24泰尔茂株式会社Catheter tube
WO2017004265A1 (en)*2015-06-302017-01-05Endologix, Inc.Locking assembly for coupling guidewire to delivery system
AU2015411406B2 (en)*2015-10-092019-02-14Transverse Medical, Inc.Catheter-based apparatuses and methods
CN105997314B (en)*2016-06-302018-06-08南京普微森医疗科技有限公司A kind of thrombus of complex function eliminates system
CN106730247A (en)*2017-02-042017-05-31成都鼎信致远科技有限公司A kind of blood vessel interposing catheter
CN112438777A (en)*2019-08-282021-03-05尤东侠Minimally invasive thrombus extraction device for treating vascular embolism
CN112933371B (en)*2021-01-262024-12-31康迪泰科(北京)医疗科技有限公司 A medical catheter
CN113041480A (en)*2021-04-222021-06-29深圳麦普奇医疗科技有限公司Guide wire for coronary intervention
CN113893443A (en)*2021-10-252022-01-07深圳麦普奇医疗科技有限公司Micro guide wire with nickel-titanium hose
CN115192872B (en)*2022-07-182023-09-26深圳市赛禾医疗技术有限公司Balloon catheter and shock wave device

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US5941896A (en)*1997-09-081999-08-24Montefiore Hospital And Medical CenterFilter and method for trapping emboli during endovascular procedures
US8562664B2 (en)*2001-10-252013-10-22Advanced Cardiovascular Systems, Inc.Manufacture of fine-grained material for use in medical devices
BRPI0707681A2 (en)*2006-02-012011-05-10Cleveland Clinic Foudation Method and apparatus for increasing blood flow through a blocked artery
CN101404960B (en)*2006-03-312012-06-06日本瑞翁株式会社Stent delivery catheter
CN200977185Y (en)*2006-12-062007-11-21成正辉Intravascular far-end protector
CN201453804U (en)*2009-07-062010-05-12成正辉Conveying and recovering duct of remote end protector inside blood vessel
CN201596219U (en)*2010-02-092010-10-06北京泰杰伟业科技有限公司Micro-catheter for vascular interventional therapy
CN101912323B (en)*2010-08-192012-07-18成正辉Brain aneurysm intravascular stent, manufacture thereof and use method thereof
CN202365970U (en)*2011-12-142012-08-08湖南瑞康通科技发展有限公司Quick blood flow reconstruction device

Also Published As

Publication numberPublication date
CN102488578A (en)2012-06-13

Similar Documents

PublicationPublication DateTitle
CN102488578B (en)Quick blood flow reconstruction device and preparation method thereof
JP7623340B2 (en) Basket for catheter device
CN102488577B (en)Intravascular guiding wire positioning device and manufacturing method thereof
CN101912289B (en)Thrombus excider and preparation method
CN103284775B (en)Encephalic thrombosis removing device
CN103230310B (en)Thoracic aortic aneurysm coated stent and thoracic aortic aneurysm minimally invasive treatment system
CN203379185U (en)Intracranial thrombus removing device
CN103055412B (en)Balloon catheter for coronary artery balloon dilatation and preparation method of balloon catheter
CN212940962U (en)Intracranial thrombus aspiration catheter
US20210170148A1 (en)Balloon Basket Catheter Device
CN101612432B (en)Transmitting and recycling pipeline of distal protector in blood vessel
CN105997314A (en)Thrombus removing system with compound function
CN102670277A (en)Cerebral apoplexy embolus protecting system and preparation method thereof
CN105662533A (en)Blood-vessel embolectomy device with helical structure and thrombus treating apparatus with the same
CN201798779U (en)Thrombus remover
CN205359560U (en)Blood vessel thrombectomy device and thrombus therapeutic instrument with helical structure
CN117618070B (en)Peripheral blood vessel thrombus taking device
CN112438777A (en)Minimally invasive thrombus extraction device for treating vascular embolism
CN202365970U (en)Quick blood flow reconstruction device
CN203060560U (en)Balloon catheter of PTCA (Percutaneous Transluminal Coronary Angioplasty)
CN201453804U (en)Conveying and recovering duct of remote end protector inside blood vessel
CN100355399C (en)Far end protecting device and its preparing method
CN214966296U (en)Multi-section basket type bolt taking support and bolt taking device thereof
CN202365969U (en)Guide wire positioning device in blood vessel
CN115919412A (en) Thrombectomy Device

Legal Events

DateCodeTitleDescription
C06Publication
PB01Publication
C10Entry into substantive examination
SE01Entry into force of request for substantive examination
C14Grant of patent or utility model
GR01Patent grant

[8]ページ先頭

©2009-2025 Movatter.jp