The implementation method of the outer thick interior thin technique of a kind of blood vessel drug eluting stent coatingTechnical field
The present invention relates to medical art, specifically the implementation method of the outer thick interior thin technique of a kind of blood vessel drug eluting stent coating.
Background technology
After current coronary stent implants coronary artery, outer surface and the coronary endometrium of coronary artery bracket are close to, inner surface then contacts towards intravascular space with blood flow, after drug stent implants coronary artery, its medication coat mainly contacted with endangium discharges medicine to endangium, to play under suppressing endometrial hyperplasia effect thus to prevent reangiostenosis, and blood may be released into towards the medicine of the medication coat in blood flow face at the implantation initial stage, cannot play on the one hand and suppress endometrial hyperplasia effect, possibility underwent coronary blood flows through microcirculation and flows to whole body more on the other hand, to body tissue's organ generation effect, likely cause unnecessary side effect, therefore thin outer thick technology outbalance in adopting in process of production, medication coat can be made more partly to be positioned at Ink vessel transfusing face, thus make medicine targeted release to endangium.In addition, existing medicine spraying coating process requires to need rack surface to have dense medicine to reach desirable result for the treatment of, but its inside tries not to be sprayed onto, otherwise the drug ingedient of internal stent has side effects to people's cognition, the rotating shaft of its structure is generally put in 1/5th place's swinging mountings of support by existing such device, and rotating shaft is fixed standard formula, cannot meet dissimilar support spraying, all be sprayed onto inside and outside such support, predetermined effect cannot be reached and to human health.
Summary of the invention
For above defect, the invention provides and a kind ofly guarantee outer thick interior thin, the implementation method that is conducive to health, the outer thick interior thin technique of the blood vessel drug eluting stent coating of result for the treatment of can be improved of stent drug coating, thus can guarantee can not admittedly for the drug ingedient of internal stent has side effects to human body after implant into body.
For achieving the above object, the present invention is by the following technical solutions:
The implementation method of the outer thick interior thin technique of a kind of blood vessel drug eluting stent coating, its key step comprises the nozzle alignment alignment of shafts adopting ultrasonic spray machine, the length of getting for spraying is that the support installing of 8mm-40mm is on corresponding frock rotating shaft, arranging and getting frock rotating shaft external diameter is the 10%-99% of shelf inner diameter, frock is fixed on the fixed axis of spraying, the fltting speed of spraying area is got 0.1-0.5 inch/min and keeps frock to rotate, described Bracket setting is that its inner surface portion is blocked by frock rotating shaft and made spraying liquid be greater than inner surface dosage in the dosage of rack outer surface, spraying comes and goes number of times and is set as 10, its nozzle liquid flow velocity is 0.1-1.0ml/min, and its frock speed of rotation is 100-300rad/min.
The beneficial effect of the implementation method of the outer thick interior thin technique of blood vessel drug eluting stent coating of the present invention is: by thin outer thick mode in employing medication coat in conjunction with special frock fixed support, stent inner surface part can be made to be blocked by frock, the proportionate relationship of frock external diameter and shelf inner diameter determines the outer thick interior thin ratio of coating, generally get the 10%-99% that frock external diameter is equivalent to shelf inner diameter, that is frock external diameter is larger relative to support external diameter ratio, support undercoating is thinner, relative external coating is also thicker, and then make spraying liquid be greater than inner surface dosage in the dosage of rack outer surface, because stent diameter and flower pattern are fixing, frock size is also constant, the uniform coating thickness that therefore can obtain rack outer surface under the condition of process stabilizing is consistent, the thickness also uniformity of inner surface, simultaneously because outer surface is greater than inner surface by the medicine sprayed, therefore the medication coat thickness of outer surface is greater than inner surface, therefore can not have side effects to human body because of the drug ingedient of internal stent after implant into body, is conducive to ensureing health, improving result for the treatment of.
Detailed description of the invention
The implementation method of the outer thick interior thin technique of the blood vessel drug eluting stent coating described in the embodiment of the present invention, its key step comprises:
(1) model is adopted to be the ultrasonic spray machine of JKMP005-01 and to arrange ultrasonic power be 1.1W, by the nozzle alignment alignment of shafts of flush coater, nozzle tip is 10mm with axle base and feed liquor nozzle flushes with ultrasonic nozzle, adjustment liquid flow velocity is 0.1-1.0ml/min, and the adjustment frock speed of rotation is 100-300rad/min;
(2) length of getting for spraying is that the support installing of 8mm-40mm is on corresponding frock rotating shaft, arranging and getting frock rotating shaft external diameter is the 10%-99% of shelf inner diameter, frock is fixed on the fixed axis of spraying, this axle has motor control can move maintenance 360 ° of rotations simultaneously to nozzle direction, axle motor is by spraying software control and manual Mobile tool key thus, determine the starting point that support sprays and terminal, the edge summary amphi position of starting point nozzle alignment rack far end, the position outside the summary of terminal nozzle alignment proximal edge;
(3) fltting speed of spraying area is got 0.1-0.5 inch/min and is kept frock to rotate, and this stent inner surface part is blocked by frock rotating shaft, and then makes spraying liquid be greater than inner surface dosage in the dosage of rack outer surface, namely realizes outer thick interior thin; Spraying comes and goes number of times and is set as 10, and then is 725 μ g and evenly complete according to bracket coating weight of weighing.