Summary of the invention
In order to develop the health inhalant that reduces tobacco poisoning and protection body health, the invention provides a kind of health care Tobacco Control type Chinese herbal medicine and inhale product, another purpose of the present invention is to provide a kind of preparation method of the Tobacco Control type Chinese herbal medicine suction product that keep healthy.
Concrete technical solution is as follows:
Health care Tobacco Control type Chinese herbal medicine is inhaled product, is made up of the raw material of following weight portion: Folium Ginkgo 50-75g, Folium Hibisci Mutabilis 5-6g, Folium Viticis Negundo 4-6g, Folium Nelumbinis 2-6g, Cacumen Platycladi 2-6g, mentha leave 2-6g, Radix Astragali 5-10g, Radix Salviae Miltiorrhizae 5-10g.
Above-mentioned health care Tobacco Control type Chinese herbal medicine is inhaled product, is made up of the raw material of following weight portion: Folium Ginkgo 65g, Folium Hibisci Mutabilis 5g, Folium Viticis Negundo 5g, Folium Nelumbinis 5g, Cacumen Platycladi 5g, mentha leave 5g, Radix Astragali 5g, Radix Salviae Miltiorrhizae 5g.
Above-mentioned health care Tobacco Control type Chinese herbal medicine is inhaled the preparation method of product, comprises following operating procedure:
Pressing formula ratio soaks Folium Ginkgo, Folium Hibisci Mutabilis, Folium Viticis Negundo, Folium Nelumbinis, Cacumen Platycladi, mentha leave 30-60 minute in water respectively; Dry, be cut into filament, fully mix homogeneously;
By formula ratio the Radix Astragali, Radix Salviae Miltiorrhizae are decocted with water, amount of water is the Radix Astragali, Radix Salviae Miltiorrhizae weight sum 5-7.5 times, decocts to the viscose glue state, and the elimination medicinal residues namely get gel juice;
With described filament and gel juice mix homogeneously, obtain tobacco shred;
Described tobacco cartridge is made the health inhalant of cigarette shape with cigarette machine.
Above-mentioned health care Tobacco Control type Chinese herbal medicine is inhaled the preparation method of product, adds cigarette holder on the health inhalant of wherein said cigarette shape.
Folium Ginkgo main component in the present invention's prescription is ginkgetin glycosides, bilobalide, Semen Ginkgo polysaccharide, trace element, ginkgoic acid, polyprenol compounds etc.; wherein ginkgetin glycosides, bilobalide have the hemorheology of improvement, regulate blood circulation, increase the heart and brain blood supply; effects such as protection heart and brain vitals histiocyte and removing oxygen-derived free radicals; with health role to the human body cardiovascular and cerebrovascular vessel, clinically be used for the treatment of diseases such as hyperlipidemia, high blood viscosity, ischemic cerebrocardiac disease.Folium Ginkgo terpene lactones can also be got through the brain neuroblastoma venation, makes it to be in positive active state; Some position of smoking addiction person's cerebral nerve absorbs and has stayed a large amount of nicotine, and Folium Ginkgo terpene lactones can be absorbed and reach these neural positions, dissolves the addiction sexually transmitted disease (STD) kitchen range that nicotine toxin causes, make it to recover normal active state again, thus the craving for tobacco of giving up.Contained alcohol, ketone, aldehyde material and monoterpene, the sesquiterpenoids material of Folium Ginkgo volatile oil all has unique odor characteristic and medicinal curative effect; Wherein linalool has the strong Radix Aucklandiae, coriander sample gas breath, has the effect of anti-inflammation, can alleviate the respiratory tract system disease that causes because of smoking; Phytol has the QINGXIANG note, is a unsaturated alcohol, can effectively control cholesterol; Caryophyllene has hot perfume (or spice) and the Radix Aucklandiae like Oleum Caryophylli; The graceful fragrance of a flower, leaf QINGXIANG rhythm that farnesene has is fresh and sweet, Flos Rosae Rugosae is sweet; Farnesene and caryophyllene have antiinflammatory, cough-relieving, relieving asthma and phlegm-dispelling functions, are used for the treatment of tracheitis clinically; The Camphora guaiacol has the stable effect of maincenter and certain antitussive effect.
Folium Hibisci Mutabilis is cool in nature, little suffering of distinguishing the flavor of.Contain flavonoid glycoside, phenols, aminoacid, reducing sugar, phlegmatic temperament.Have the lung heat clearing removing heat from blood, the detumescence and apocenosis effect can be used for cough due to lung-heat, hypertrophic rhinitis, lymphadenitis, carbuncle furuncle abscess, acute otitis media etc.
Folium Viticis Negundo gas perfume (or spice), property is flat, little suffering of distinguishing the flavor of.Chemical constituent contains volatile oil, and a-pinene, camphene, terpilene dihydrochloride, eugenol, β-Flos Caryophylli alkene, trans-Caryophyllene oxide, beta-elemene are arranged in the oil.Have eliminate the phlegm, cough-relieving, antiasthmatic effect.Can be used for chronic bronchitis.
Folium Nelumbinis gas delicate fragrance; Acrid in the mouth is little puckery, cool in nature, GUIXIN, liver, spleen channel; Have heat-clearing and toxic substances removing, summer heat relieving and dampness eliminating, spleen invigorating yang invigorating, the effect of dissipating blood stasis hemostasis; Folium Nelumbinis contains multiple alkaloids such as nuciferine, miltanthin and nuciferine and vitamin C, polysaccharide.The Flavonoid substances that is rich in the Folium Nelumbinis is the scavenger of most of oxygen-derived free radicals, and it can increase coronary flow, and acute myocardial ischemia is had protective effect; Treatment coronary heart disease, hypertension etc. there is remarkable result.
Cacumen Platycladi bitter in the mouth, puckery, cold nature.Leaf contains volatile oil 0.6%-1%, and thujene, absinthol, fenchone, pinene, caryophyllene etc. are wherein arranged.Have antitussive, eliminate the phlegm, relieving asthma, stop blooding, effect such as calm, antibiotic.
Mentha leave acrid in the mouth cool in nature has that dispelling wind and heat pathogens, clearing throat, rash are antipruritic, the effect of anti-inflammatory analgesic.Herba Menthae contains volatile oil, and its main component is menthol, menthone, isomenthone, rosmarinic acid, glycoside and multiple free amino acid.Have that stomach invigorating is dispeled the wind, eliminated the phlegm, function of gallbladder promoting, spasmolytic, improve laryngopharynx swelling and pain due to the cat fever, the inflammation symptom of respiratory tract is had therapeutical effect; Also can relax headache, enhance metabolism, bring high blood pressure down, nourish heart.Its refrigerant fragrance, can be gently nervous emotion, can improve spirit, make body and mind vigorously pleased, help to fall asleep.
Radix Astragali nature and flavor are sweet, tepor; Return lung, spleen, liver, kidney channel.Have effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.The Radix Astragali contains various trace elements such as Saponin, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have the enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
Radix Salviae Miltiorrhizae nature and flavor hardship is slightly cold; GUIXIN, Liver Channel.Contain fat-soluble Diterpenes composition and water miscible phenolic acid composition, also contain compositions such as flavonoid, triterpenes, sterol.Have coronary artery dilating, antithrombotic, improve microcirculation, effect such as heart tonifying, blood fat reducing.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, the lump in the abdomen caking, skin infection swells and ache, the tumbling down pain of injury, menoxenia, puerperal stasis of blood pain etc.
Pharmacology test studies show that Chinese herbal medicine Medicated cigarette of the present invention has relieving cough and expelling phlegm antiinflammatory, blood fat reducing, improves microcirculation and blood supply of cardiac muscle, blood pressure lowering, improvement memory, removes oxygen-derived free radicals, anti-fatigue effect; Toxicologic study shows safety non-toxic of the present invention.Crowd's examination is sucked the result and is shown that the present invention has smoking cessation Tobacco Control function, and has certain health care, uses safety non-toxic, and mouthfeel is better, and local flavor is pure.
Be pharmacology pharmacodynamic test of the present invention and data below:
Experiment one: chronic pharyngitis model
36 of normal mouses are divided into 3 groups at random by body weight: normal control group, chronic pharyngitis model group, Chinese herbal medicine suction product group, 12 every group.Except the normal control group, each sprays mice the 1st~20d its pharyngeal 1 time with 5% ammonia, presses with aerosol apparatus spray 2 at every turn.21d begins, normal control group and chronic pharyngitis model group mouse breathing normal air, Chinese herbal medicine suction product group mice every day 12 of passive suction this product in the experimental smoking apparatus smog box of self-control, fumigation is 3 days continuously.Observe the pharyngeal situation of animal every day, comprise mucosa form and color and luster, oral secretion, experiment finishes to do routine blood test to be measured, and calculates leukocyte and classification.The result shows (seeing Table 1), compares with the normal control group, and the pharyngeal inflammatory reaction symptom of model group is obvious, and blood middle leukocytes (WBC) and lymphocyte (LYM) increase.Chinese herbal medicine suction product group mice WBC and LYM descend to some extent, and pharyngeal situation is obviously improved.Illustrate that Chinese herbal medicine suction product of the present invention have mitigation to chronic pharyngitis, and have antiinflammatory action.
The influence of leukocyte and classification in the table 1. pair chronic pharyngitis model mice blood
X ± s.n=12. compares with model group,*P<0.05,*P<0.01.
Experiment two: Antitussive and Expectorant Effect
24 of normal mouses are divided into 2 groups at random by body weight: normal control group and Chinese herbal medicine suction product group, 12 every group.Normal air is inhaled in the normal control group calling, Chinese herbal medicine Medicated cigarette group mice every day 12 of passive suction this product in the experimental smoking apparatus smog box of self-control, 2 weeks of fumigation continuously.After 2 weeks, adopt strong aqua ammonia to draw the method for coughing, the record mice is drawn and coughs the incubation period that begins to cough occurring from accepting ammonia, and the cough number of times in the 3min.The result shows (seeing Table 2), compares with the normal control group, and Chinese herbal medicine is inhaled product and can significantly be reduced because strong aqua ammonia stimulates the number of times of coughing in 3 minutes that cause, prolongs cough latent period.Illustrate that the present invention has obvious antitussive effect.
Each mouse peritoneal is injected 5% phenol red 10ml/kg then, puts to death behind the 30min, peels off the trachea surrounding tissue, cut one section trachea to the trachea bifurcation from thyroid cartilage, put into the test tube that fills the 2ml normal saline, add 0.1ml NaOH again, 721 type spectrophotometer 546nm wavelength places survey the OD value; With the phenol red standard curve of doing, according to the phenol red secretory volume of curve calculation mice trachea section.The result shows (seeing Table 2), compares with the normal control group, and Chinese herbal medicine is inhaled product can obviously increase the phenol red excretion amount of mice, illustrates that the present invention has obvious phlegm-dispelling functions.
The Antitussive and Expectorant Effect of table 2. pair mice
X ± s.n=12. compares with the normal control group,*P<0.05,*P<0.01.
Experiment three: high blood lipid model
36 of normal mouses are divided into 3 groups at random by body weight: normal control group, hyperlipidemia model group, Chinese herbal medicine suction product group, 12 every group.Normal air is inhaled in normal control group and hyperlipidemia model group calling, Chinese herbal medicine suction product group mice every day 12 of passive suction this product in the experimental smoking apparatus smog box of self-control, 8 weeks of fumigation continuously.Copy high fat animal model with high fat diet.Fat is mainly Adeps Sus domestica in the high lipid food, and heat consists of: fat accounts for 60%, and carbohydrate accounts for 20%, and protein accounts for 20%.Normal feedstuff heat consists of: carbohydrate accounts for 65%, and protein accounts for 25%, and fat accounts for 10%.Experimental session normal control group gives full diet, and hyperlipidemia model group and Chinese herbal medicine suction product group give high fat diet and induced for 8 weeks.Experiment detection of end lipids contents and blood flow become index.The result shows (seeing Table 3,4), compares with the normal control group, and hyperlipidemia model group mice blood lipid level significantly raises.Chinese herbal medicine suction product group mice is compared blood fat with hyperlipidemia model group mice and descends to some extent.Blood flow becomes every index and obviously improves.Illustrate that Chinese herbal medicine suction product of the present invention have certain blood fat reducing and improve the effect that blood flow becomes.
The influence of table 3. pair high blood lipid model mice serum blood lipid level
X ± s.n=12. compares with model group,*P<0.01.
The influence that table 4. pair high blood lipid model mice blood flow becomes
X ± s.n=12. compares with model group,*P<0.05,*P<0.01.
Experiment four: myocardial ischemia reperfusion injury model
18 of normal rabbits are divided into 3 groups at random by body weight: normal control group, myocardial ischemia reperfusion injury model group, Chinese herbal medicine suction product group, 6 every group.Normal control group, model group are breathed normal air, Chinese herbal medicine suction product group rabbit every day 12 of passive suction this product in the experimental smoking apparatus smog box of self-control, 4 weeks of fumigation continuously.Adopt the method for ligation rabbit ramus descendens anterior arteriae coronariae sinistrae to prepare ischemia-reperfusion injury model, cutout 40min recovers blood flow and pours into 4h again.Experiment finishes to get blood immediately and serum paraoxonase acid kinase and cardiac muscular tissue's creatine kinase level detect in cardiac muscular tissue.The result shows (seeing Table 5), compares with the normal control group, and model group rabbit anteserum phosphokinase obviously raises, and cardiac muscular tissue's creatine kinase level obviously descends.Chinese herbal medicine suction product group rabbit is compared phosphokinase and descends with the model group rabbit, the creatine kinase level obviously rises.Illustrate that Chinese herbal medicine suction product of the present invention have strong protective effect for myocardial ischemia reperfusion injury, can alleviate myocardial ischemia, improve heart blood supply.
The influence of table 5. pair myocardial ischemia reperfusion injury rabbit phosphokinase and creatine kinase level
X ± s.n=6. compares with model group,*P<0.05,*P<0.01.
Experiment five: spontaneously hypertensive rat model
12 of spontaneous hypertensive rats (SHR) are divided into 2 groups at random by body weight: SHR model group and Chinese herbal medicine suction product group, 6 every group.Other establishes 6 of rats in normal control group.Normal control group and SHR model group rats breathing normal air, Chinese herbal medicine suction product group rat every day 12 of passive suction this product in the experimental smoking apparatus smog box of self-control, 4 weeks of fumigation continuously.The experiment detection of end is respectively organized rat blood pressure.The result shows that rats in normal control group blood pressure SBP is 123 ± 13mmHg; SHR model group rat blood pressure is 182 ± 13mmHg, and Chinese herbal medicine suction product group rat blood pressure is 131 ± 11mmHg.Illustrate that Chinese herbal medicine suction product of the present invention have certain hypotensive activity.
Experiment six: the artificial aging model of D-galactose
(D-galactose, D-gal) artificial aging model are established normal control group, D-gal model group, Chinese herbal medicine suction product and are organized 3 groups, 12 every group to adopt mice D-galactose.D-gal model group, Chinese herbal medicine suction product group subcutaneous injection D-gal (40mg/kg) handled for 8 weeks.Normal control group and D-gal model group are breathed normal air, Chinese herbal medicine suction product group mice every day 12 of passive suction this product in the experimental smoking apparatus smog box of self-control, 8 weeks of fumigation continuously.Adopt step down test to observe memory function: diving tower errors number in the incubation period that the record mice jumps off and the 5min.Experiment finishes to get murine liver tissue and detects peroxidating metabolite MDA content and antioxidase T-SOD activity.The result shows (seeing Table 6), compares with normal control group of the same age, and the D-gal mouse aging obviously shortens incubation period, and errors number obviously raises.Chinese herbal medicine suction product group can be improved the hair luster degree of D-gal mouse aging, obviously prolongs the incubation period of mouse aging and reduces errors number, can obviously improve the memory function of D-gal mouse aging.Chinese herbal medicine suction product group is compared with model group, and MDA content obviously descends, and antioxidase T-SOD is active obviously to raise.Illustrate that the present invention has the memory of improvement, removes free radical and antioxidation.
The influence of table 6. pair D-galactose mouse aging coordination exercise regulating liver-QI tissue SOD, MDA
X ± s.n=12. compares with model group,*P<0.05,*P<0.01.
Experiment seven: antifatigue effect
24 of normal mouses are divided into 2 groups at random by body weight: normal control group and Chinese herbal medicine suction product group, 12 every group.Normal air is inhaled in the normal control group calling, Chinese herbal medicine suction product group mice every day 12 of passive suction this product in the experimental smoking apparatus smog box of self-control, 4 weeks of fumigation continuously.Method with swimming with a load attached to the body prepares tired model, observes exhausting property of mice power swimming time.The result shows that normal control group swimming time is 0.86 ± 0.14min, and Chinese herbal medicine suction product group mice swimming time is 1.27 ± 0.23min.Illustrate that Chinese herbal medicine suction product of the present invention have antifatigue effect.
More than in each pharmacodynamic experiment, each mice general state is good, it is normal to ingest, drink water, the mental status is good.Product safety of the present invention is described, almost non-toxic side reaction.
Experiment eight: toxicological experiment
40 SD rats are divided into 2 groups at random, i.e. normal control group group and Chinese herbal medicine suction product group, 20 every group, male and female half and half.Normal air is inhaled in the normal control group calling, Chinese herbal medicine suction product group rat every day 60 of passive suction this product in the experimental smoking apparatus smog box of self-control, 12 weeks of fumigation continuously.Observe and record general state and the food-intake of rat every day.Weigh once weekly.Experiment finishes the femoral artery blood-letting and collects blood, measures hematology and blood biochemical and learns index.Every Mus is cored, liver, spleen, lung, kidney, brain, thymus, adrenal gland, thyroid, testis, prostate or ovary, 13 internal organs in uterus are weighed, and calculated organ coefficient; Send the pathological tissue morphological examination with following specimen: the heart, liver, spleen, lung, kidney, stomach, thymus, adrenal gland, thyroid, testis and epididymis, prostate or ovary, uterus.The result shows, compares with the normal control group, and Chinese herbal medicine of the present invention is inhaled product does not all have obvious the influence to the general situation of rat, routine urinalysis, hematology, blood biochemical and histopathology observation.Show product safety of the present invention, almost non-toxic side reaction.
The present invention is compared with prior art: the present invention is that raw material is made with Folium Ginkgo, Folium Hibisci Mutabilis, Folium Viticis Negundo, Folium Nelumbinis, Cacumen Platycladi, mentha leave, the Radix Astragali, Radix Salviae Miltiorrhizae, belongs to the herbal health care that non-Nicotiana tabacum L. makes and inhales product.This health inhalant had not both had harmful materials such as tar and nicotine, can give full play to the drug action of Folium Ginkgo, Folium Hibisci Mutabilis, Folium Viticis Negundo, Folium Nelumbinis, Cacumen Platycladi, mentha leave, the Radix Astragali, Radix Salviae Miltiorrhizae again, have clearly cigarette sharp larynx, antiinflammatory, blood fat reducing, improve microcirculation and blood supply of cardiac muscle, effects such as blood pressure lowering, slow down aging, removing free radical, resisting fatigue, health-care effect is wide and unique.
The specific embodiment
Below in conjunction with embodiment, the present invention is done to describe further.
Embodiment 1:
Get Folium Ginkgo 65g, Folium Hibisci Mutabilis 5g, Folium Viticis Negundo 5g, Folium Nelumbinis 5g, Cacumen Platycladi 5g, mentha leave 5g, Radix Astragali decoction pieces 5g and salvia piece 5g.
The preparation method that health care Tobacco Control type Chinese herbal medicine is inhaled product comprises following operating procedure:
1, Folium Ginkgo, Folium Hibisci Mutabilis, Folium Viticis Negundo, Folium Nelumbinis, Cacumen Platycladi, mentha leave were soaked 30-60 minute in water respectively; Dry, be cut into filament, fully mix homogeneously;
2, the Radix Astragali, Radix Salviae Miltiorrhizae are decocted with water, amount of water is the Radix Astragali, Radix Salviae Miltiorrhizae weight sum 7.5 times, and namely 75g decocts to the viscose glue state, and the elimination medicinal residues namely get gel juice;
3, with filament and the gel juice mix homogeneously of mix homogeneously, obtain tobacco shred;
4, with cigarette machine described tobacco cartridge is made the health inhalant of cigarette shape.Can add cigarette holder on the health inhalant of cigarette shape.Prepare 100 cigarettes altogether.
Embodiment 2:
Get Folium Ginkgo 50g, Folium Hibisci Mutabilis 6g, Folium Viticis Negundo 6g, Folium Nelumbinis 6g, Cacumen Platycladi 6g, mentha leave 6g, Radix Astragali decoction pieces 10g and salvia piece 10g.
The Radix Astragali, Radix Salviae Miltiorrhizae are decocted with water, and amount of water is the Radix Astragali, Radix Salviae Miltiorrhizae weight sum 5 times, i.e. 100g.
Other preparation process is with embodiment 1.Prepare 90 health inhalants altogether.
Embodiment 3:
Get Folium Ginkgo 75g, Folium Hibisci Mutabilis 5g, Folium Viticis Negundo 4g, Folium Nelumbinis 2g, Cacumen Platycladi 2g, mentha leave 2g, Radix Astragali decoction pieces 5g and salvia piece 5g.
The Radix Astragali, Radix Salviae Miltiorrhizae are decocted with water, and amount of water is the Radix Astragali, Radix Salviae Miltiorrhizae weight sum 5 times, i.e. 50g.
Other preparation process is with embodiment 1.Prepare 100 health inhalants altogether.
In order to the health inhalant that the top method is made, through 60 smoker's tests, each 1-2 props up, and every day 3-4 time, uses continuously 1-2 month.Have 41 suction persons to guard against cigarette and sucking the present invention always, quit smoking rate reaches 68%; There are 15 suction persons to reduce the quantity of smoking, reduced to more than 15 by original smoking every day and inhale about 8; 12 suction persons suffer with chronic bronchitis, and symptom is obviously improved; 9 suction persons suffer from hyperlipemia, and blood fat descends to some extent; 5 suction persons suffer from vascular hypertension, are keeping under original Altace Ramipril treatment, and blood pressure descends to some extent, and symptom uncomfortable in chest is alleviated to some extent.Feeling after all suction person's suctions is: smog is soft strong, comfortable taste, and local flavor is pure, has lattice of one's own, and refreshment, the clean oral cavity and throat effect of profit are arranged.Health inhalant of the present invention can make the medicated cigarette smoker give up craving for tobacco; The smoking cessation process is not painful, and groups of people are changed into from smoking and are ready to suck this product, slowly abandons the present invention again and inhales product, no addiction, thereby thoroughly smoking cessation.Therefore the present invention is a kind of comparatively ideal health inhalant and traditional Nicotiana tabacum L. Medicated cigarette succedaneum.