CN101810470A - Physiological signal measurement module and method - Google Patents

Abstract

The invention relates to a physiological signal measuring module, which comprises a physiological signal sensing unit, a posture sensing unit and a processing unit. The physiological signal sensing unit measures an electrocardiosignal and a pulse signal of a testee. The posture sensing unit senses a position of the physiological signal measuring module and outputs a plurality of position signals. The processing unit receives the electrocardiosignals, the pulse signals and the position signals and is used for generating height change parameters representing the height difference between the physiological signal measuring module and the reference position according to the position signals. The processing unit also calculates the current pulse wave delay time according to the electrocardio signals and the pulse signals, compensates the current pulse wave delay time according to the height change parameters to obtain the compensated pulse wave delay time, and obtains the blood pressure signals according to the compensated pulse wave delay time.

Description

Translated fromChinese

生理信号测量模块及方法Physiological signal measurement module and method

技术领域technical field

本发明是有关于一种生理信号测量模块，特别是有关于一种移动式血压信号测量模块。The invention relates to a physiological signal measurement module, in particular to a mobile blood pressure signal measurement module.

背景技术Background technique

随着社会的高龄化，年老人口逐渐增加，对于医疗设备的需求亦大幅增加，使得医疗资源供不应求大型医院经常人满为患。再者，生活压力的增加使得现代人罹患心血管疾病机率也提高，其中，高血压更是造成中风的主要因子。因此，生理信号自我测量设备已逐渐成为医疗产业发展的重要目标。通过生理信号自我测量的方式，个人能够随时监控自己的生理状况，并能减少医疗资源浪费。With the aging of the society, the elderly population is gradually increasing, and the demand for medical equipment has also increased significantly, making the supply of medical resources in short supply and large hospitals are often overcrowded. Furthermore, the increase in life pressure has increased the risk of cardiovascular diseases in modern people, among which high blood pressure is the main factor causing stroke. Therefore, physiological signal self-measurement equipment has gradually become an important goal of the development of the medical industry. Through self-measurement of physiological signals, individuals can monitor their own physiological conditions at any time and reduce the waste of medical resources.

已知的血压测量设备是利用腕带式气囊感测技术，其通过气囊的充放气来测量血压。但是，此感测技术无法连续地测量血压，且气囊的充放气需花费较长时间。此外，腕带式的血压测量设备会因为手腕与心脏的高度差而造成测量误差。Known blood pressure measuring devices utilize wristband airbag sensing technology, which measures blood pressure through inflation and deflation of the airbag. However, this sensing technology cannot continuously measure blood pressure, and it takes a long time to inflate and deflate the airbag. In addition, wrist-worn blood pressure measurement equipment will cause measurement errors due to the height difference between the wrist and the heart.

因此，期望提供一种生理信号测量模块，其可随身携带，且能补偿测量部位与心脏间的高度差所造成的误差。Therefore, it is desired to provide a physiological signal measurement module, which can be carried around and can compensate the error caused by the height difference between the measurement site and the heart.

发明内容Contents of the invention

本发明所要解决的技术问题在于提供一种生理信号测量模块及方法，其可随身携带，且能补偿测量部位与心脏间的高度差所造成的误差。The technical problem to be solved by the present invention is to provide a physiological signal measurement module and method, which can be carried around and can compensate the error caused by the height difference between the measurement site and the heart.

本发明提供一种生理信号测量模块，包括生理信号感测单元、姿势感测单元、以及处理单元。生理信号感测单元测量受测者的心电信号与脉搏信号。姿势感测单元感测生理信号测量模块的位置，并输出多个位置信号。处理单元接收心电信号、脉搏信号、与位置信号，用以根据位置信号来产生表示生理信号测量模块与参考位置间的高度差的变化参数。处理单元还根据心电信号与脉搏信号来计算当前脉波延迟时间，且根据高度变化参数来补偿当前脉波延迟时间以获得补偿脉波延迟时间，并根据补偿脉波延迟时间来获得血压信号。The present invention provides a physiological signal measurement module, which includes a physiological signal sensing unit, a posture sensing unit, and a processing unit. The physiological signal sensing unit measures the ECG signal and pulse signal of the subject. The posture sensing unit senses the position of the physiological signal measuring module and outputs a plurality of position signals. The processing unit receives the electrocardiographic signal, the pulse signal, and the position signal, and generates a change parameter representing the height difference between the physiological signal measurement module and the reference position according to the position signal. The processing unit also calculates the current pulse wave delay time according to the ECG signal and the pulse signal, and compensates the current pulse wave delay time according to the altitude change parameter to obtain the compensated pulse wave delay time, and obtains the blood pressure signal according to the compensated pulse wave delay time.

本发明另提供一种生理信号测量方法，首先，以一生理信号测量模块来测量受测者的心电信号与脉搏信号，接着测量生理信号测量模块与参考位置之间的高度，以产生高度变化参数。根据心电信号与脉搏信号来计算当前脉波延迟时间。根据高度变化参数来补偿当前脉波延迟时间以获得补偿脉波延迟时间。最后，根据补偿脉波延迟时间来获得血压信号。The present invention also provides a physiological signal measurement method. Firstly, a physiological signal measurement module is used to measure the ECG signal and pulse signal of the subject, and then the height between the physiological signal measurement module and the reference position is measured to generate a height change. parameter. Calculate the current pulse wave delay time according to the ECG signal and the pulse signal. Compensate the current pulse delay time according to the altitude change parameter to obtain the compensated pulse delay time. Finally, the blood pressure signal is obtained according to the compensated pulse wave delay time.

本发明的生理信号测量模块可随身携带，且能补偿测量部位与心脏间的高度差所造成的误差。The physiological signal measurement module of the present invention can be carried around, and can compensate the error caused by the height difference between the measurement site and the heart.

为使本发明能更明显易懂，下文特举一较佳实施例，并配合所附附图，作详细说明如下。In order to make the present invention more comprehensible, a preferred embodiment will be described in detail below together with the accompanying drawings.

附图说明Description of drawings

图1表示根据本发明实施例的生理信号测量模块架构；FIG. 1 shows a physiological signal measurement module architecture according to an embodiment of the present invention;

图2表示生理信号测量模块1的外观示意图；FIG. 2 shows a schematic diagram of the appearance of the physiological signal measurement module 1;

图3表示脉波延迟时间的示意图；以及Fig. 3 represents the schematic diagram of pulse wave delay time; And

图4表示根据本发明实施例的生理信号测量流程图。Fig. 4 shows a flowchart of physiological signal measurement according to an embodiment of the present invention.

【主要组件符号说明】[Description of main component symbols]

1～生理信号测量模块；1～physiological signal measurement module;

10～生理信号感测单元；10～physiological signal sensing unit;

11～姿势感测单元；11～posture sensing unit;

12～处理单元；12 ~ processing unit;

13～内存；13 ~ memory;

14～显示单元；14 ~ display unit;

15～外部装置；15 ~ external device;

20～输入端口；20 ~ input port;

21、22、23～感测电极；21, 22, 23～sensing electrodes;

24～光传感器；24 ~ light sensor;

140～显示面板。140～display panel.

具体实施方式Detailed ways

图1是表示根据本发明实施例的生理信号测量模块架构。参阅图1，生理信号测量模块1包括生理信号感测单元10、姿势感测单元11、处理单元12、内存13、以及显示单元14。图2是表示生理信号测量模块1的外观示意图。生理信号测量模块操作在初始参数设定模式或测量模式下。FIG. 1 shows the architecture of a physiological signal measurement module according to an embodiment of the present invention. Referring to FIG. 1 , the physiological signal measurement module 1 includes a physiological signal sensing unit 10 , a posture sensing unit 11 , a processing unit 12 , a memory 13 , and a display unit 14 . FIG. 2 is a schematic diagram showing the appearance of the physiological signal measurement module 1 . The physiological signal measurement module operates in the initial parameter setting mode or the measurement mode.

在初始参数设定模式下，将一外部装置15连接至生理信号测量模块1的输入端口20。外部装置15可以是已知的血压计，例如电子式气囊血压计。由外部装置15来测量受测者在数秒内的平均舒张压与收缩压，并透过输入端口20将所测得的舒张压与收缩压输入至内存13，作为初始舒张压参数DBP₀与初始收缩压参数SBP₀。In the initial parameter setting mode, anexternal device 15 is connected to theinput port 20 of the physiological signal measurement module 1 . Theexternal device 15 may be a known sphygmomanometer, such as an electronic cuff sphygmomanometer. Theexternal device 15 measures the average diastolic and systolic blood pressure of the subject within a few seconds, and the measured diastolic and systolic blood pressure are input to the memory 13 through theinput port 20 as the initial diastolic pressure parameters DBP₀ and initial Systolic blood pressure parameter SBP₀ .

参阅图2，生理信号测量模块1具有三个感测电极21-23与一个光传感器24。受测者的三只手指分别触碰感测电极21-23，借以撷取心电信号(例如，左手的食指触碰感测电极23、左手的大拇指触碰感测电极21、以及右手的大拇指触碰感测电极22)。用来撷取脉搏信号的光传感器24可与感测电极23结合，因此，受测者的左手食指是同时触碰感测电极23与光传感器24。在此数秒内的血压测量期间，生理信号测量模块1的生理信号感测单元10同时透过感测电极21-23与光传感器24来测量数秒的心电信号与脉搏信号，以作为初始心电信号ECG₀与初始脉搏信号PPG₀。处理单元12接收初始心电信号ECG₀与初始脉搏信号PPG₀，并根据初始心电信号ECG₀与初始脉搏信号PPG₀来计算脉波延迟时间(Pulse Transit Time，PTT)。此技术领域的人员已知，如图3所示，脉波延迟时间是心电信号与脉搏信号之间的时间差(例如，心电信号R波与脉波信号位准开始上升的时间点)。在初始参数设定模式下，处理单元12计算获得此数秒内多个脉波延迟时间的值，且将这些值做平均运算以获得初始脉波延迟时间PTT₀。在获得初始脉波延迟时间PTT₀后，处理单元12根据式(1)来计算关系常数K：Referring to FIG. 2 , the physiological signal measurement module 1 has three sensing electrodes 21 - 23 and onelight sensor 24 . The subject's three fingers touch the sensing electrodes 21-23 respectively, so as to capture the ECG signal (for example, the index finger of the left hand touches thesensing electrode 23, the thumb of the left hand touches thesensing electrode 21, and the thumb of the right hand touches thesensing electrode 21, The thumb touches the sensing electrode 22). Thelight sensor 24 used to capture the pulse signal can be combined with thesensing electrode 23 , so the subject's left index finger touches thesensing electrode 23 and thelight sensor 24 at the same time. During the blood pressure measurement within several seconds, the physiological signal sensing unit 10 of the physiological signal measurement module 1 simultaneously measures the ECG signal and the pulse signal for several seconds through the sensing electrodes 21-23 and thelight sensor 24 as the initial ECG Signal ECG₀ and initial pulse signal PPG₀ . The processing unit 12 receives the initial ECG signal ECG₀ and the initial pulse signal PPG₀ , and calculates a pulse delay time (Pulse Transit Time, PTT) according to the initial ECG signal ECG₀ and the initial pulse signal PPG₀ . Those skilled in the art know that, as shown in FIG. 3 , the pulse delay time is the time difference between the ECG signal and the pulse signal (for example, the time point when the R wave of the ECG signal and the pulse signal level start to rise). In the initial parameter setting mode, the processing unit 12 calculates a plurality of pulse delay time values within the several seconds, and averages these values to obtain the initial pulse delay time PTT₀ . After obtaining the initial pulse wave delay time PTT₀ , the processing unit 12 calculates the relational constant K according to formula (1):

K＝SBP₀×PTT₀    式(1)K＝SBP₀ ×PTT₀ Equation (1)

根据式(1)可得知，关系常数K是有关于初始收缩压参数SBP₀与初始脉波延迟时间PTT₀。According to formula (1), it can be known that the relationship constant K is related to the initial systolic blood pressure parameter SBP₀ and the initial pulse delay time PTT₀ .

在此数秒的血压测量期间，姿势感测单元11同时来测量此时的生理信号测量模块1与受测者的心脏间的初始高度差H₀。姿势感测单元11依据生理信号测量模块1的位置来获得重力(G)在X轴、Y轴、与Z轴方向的分量，以产生对应的初始位置信号，即X₀、Y₀及Z₀信号。处理单元12根据Y₀与Z₀来计算受测者此时下臂倾斜角度θ₀，如式(2)During the several-second blood pressure measurement, the posture sensing unit 11 simultaneously measures the initial height difference H₀ between the physiological signal measurement module 1 and the subject's heart. The posture sensing unit 11 obtains the components of gravity (G) in the X-axis, Y-axis, and Z-axis directions according to the position of the physiological signal measurement module 1, so as to generate corresponding initial position signals, that is, X₀ , Y₀ , and Z₀ Signal. The processing unit 12 calculates the inclination angle θ₀ of the lower arm of the subject at this time according to Y₀ and Z₀ , as shown in formula (2)

${\mathrm{\θ}}_0={\tan }^{-1}\left(\frac{Y_0}{Z_0}\right)$式(2)${\mathrm{\θ}}_0={\mathrm{the\; tan}}^{-1}\left(\frac{Y_0}{Z_0}\right)$ Formula (2)

在获得下臂倾斜角度θ₀后，处理单元12根据式(3)来计算生理信号测量模块1与受测者的心脏间的初始高度差H₀：After obtaining the inclination angle θ₀ of the lower arm, the processing unit 12 calculates the initial height difference H₀ between the physiological signal measurement module 1 and the heart of the subject according to formula (3):

H₀＝L₀-L₁+L₂sinθ₀    式(3)H₀ ＝L₀ -L₁ +L₂ sinθ₀ Formula (3)

其中，L₀表示受测者的心脏至肩膀高度、L₁表示受测者的上臂长度、而L₂表示受测者的下臂长度。受测者可透过生理信号测量模块1的输入单元(未显示)来预先输入其身高，且处理单元12根据受测者的身高由标准身材比例(stand body proportion)公式来求出数值L₀、L₁、与L₂，并将获得的数值L₀、L₁、与L₂储存至内存13。Wherein, L₀ represents the height from the heart to the shoulder of the test subject, L₁ represents the length of the upper arm of the test subject, and L₂ represents the length of the lower arm of the test subject. The subject can pre-input his height through the input unit (not shown) of the physiological signal measurement module 1, and the processing unit 12 calculates the value L according to the subject's height by a standard body ratio (stand body proportion) formula_. , L₁ , and L₂ , and store the obtained values L₀ , L₁ , and L₂ into the memory 13 .

当处理单元12完成计算初始脉波延迟时间PTT₀、关系常数K、以及初始高度差H₀后，将这些初始参数传送至内存13储存。在上述初始参数设定模式完成后，内存13已储存个体化的血压校正所需的初始参数，即初始舒张压参数DBP₀、初始收缩压参数SBP₀、初始脉波延迟时间PTT₀、关系常数K、以及初始高度差H₀。之后，可移除外部装置15与输入端口20的连接。After the processing unit 12 finishes calculating the initial pulse delay time PTT₀ , the relation constant K, and the initial height difference H₀ , these initial parameters are sent to the memory 13 for storage. After the above initial parameter setting mode is completed, the memory 13 has stored the initial parameters required for individualized blood pressure correction, namely the initial diastolic blood pressure parameter DBP₀ , the initial systolic blood pressure parameter SBP₀ , the initial pulse wave delay time PTT₀ , and the relationship constant K, and the initial height difference H₀ . Afterwards, the connection of theexternal device 15 to theinput port 20 can be removed.

在初始参数设定模式结束后，若随时欲测量受测者的血压信号时，生理信号测量模块1则进入测量模式。参阅图1及2，在测量模式下，受测者的相同三只手指(即左手的食指与大拇指、以及右手的大拇指)分别触碰感测电极21-23，同时，左手的食指也触碰光传感器24。生理信号感测单元10同时透过感测电极21-23与光传感器24来测量当前的心电信号ECG_N与脉搏信号PPG_N。处理单元12接收当前的心电信号ECG_N与脉搏信号PPG_N，并根据当前的心电信号ECG_N与脉搏信号PPG_N来计算当前脉波延迟时间PTT_N。After the initial parameter setting mode ends, if the blood pressure signal of the subject is to be measured at any time, the physiological signal measurement module 1 enters the measurement mode. Referring to Figures 1 and 2, in the measurement mode, the subject's same three fingers (ie, the index finger and thumb of the left hand, and the thumb of the right hand) touch the sensing electrodes 21-23 respectively, and at the same time, the index finger of the left hand also touches the sensing electrodes 21-23. Touchlight sensor 24. The physiological signal sensing unit 10 simultaneously measures the current electrocardiographic signal ECG_N and the pulse signal PPG_N through the sensing electrodes 21 - 23 and thelight sensor 24 . The processing unit 12 receives the current ECG signal ECG_N and the pulse signal PPG_N , and calculates the current pulse delay time PTT_N according to the current ECG signal ECG_N and the pulse signal PPG_N .

在此测量模式中，姿势感测单元11同时测量此时的生理信号测量模块1与受测者的心脏间的高度差HN。同样地，姿势感测单元11依据生理信号测量模块1的位置来获得重力(G)在X轴、Y轴、与Z轴方向的分量，以产生对应的位置信号，即X_N、Y_N、及Z_N信号。处理单元12根据Y_N信号与Z_N信号来计算受测者此时下臂倾斜角度θ_N，如式(4)In this measurement mode, the posture sensing unit 11 simultaneously measures the height difference HN between the physiological signal measurement module 1 and the heart of the subject at this time. Similarly, the posture sensing unit 11 obtains the components of gravity (G) in the X-axis, Y-axis, and Z-axis directions according to the position of the physiological signal measurement module 1 to generate corresponding position signals, that is, X_N , Y_N , and Z_N signal. The processing unit 12 calculates the inclination angle θ_N of the lower arm of the subject at this time according to the Y_N signal and the Z_N signal, as shown in formula (4)

${\mathrm{\θ}}_N={\tan }^{-1}\left(\frac{Y_N}{Z_N}\right)$式(4)${\mathrm{\θ}}_N={\mathrm{the\; tan}}^{-1}\left(\frac{Y_N}{Z_N}\right)$ Formula (4)

在获得下臂倾斜角度θ_N后，处理单元12根据式(4)来计算生理信号测量模块1与受测者的心脏间的高度差H_N：After obtaining the inclination angle θ_N of the lower arm, the processing unit 12 calculates the height difference H_N between the physiological signal measurement module 1 and the heart of the subject according to formula (4):

H_N＝L₀-L₁+L₂sinθ_N    式(5)H_N ＝L₀ -L₁ +L₂ sinθ_N formula (5)

在处理单元12计算出在测量模式下生理信号测量模块1与受测者的心脏间的高度差H_N后，根据在初始参数设定模式下的高度差H₀(读取自内存13)与在测量模式下的高度差H_N，则可以得到生理信号测量模块1在测量模式下与在初始参数设定模式下的高度差ΔH，以作为高度变化参数。换句话说，在初始参数设定模式下生理信号测量模块1的位置视为参考位置，而在测量模式下处理单元12则是依据Y_N信号与Z_N信号来计算生理信号测量模块1与参考位置的高度差ΔH(高度变化参数)。After the processing unit 12 calculates the height difference_HN between the physiological signal measurement module 1 and the heart of the subject in the measurement mode, according to the height difference_H0 (read from the memory 13) and For the height difference H_N in the measurement mode, the height difference ΔH of the physiological signal measurement module 1 in the measurement mode and the initial parameter setting mode can be obtained as the height change parameter. In other words, in the initial parameter setting mode, the position of the physiological signal measurement module 1 is regarded as the reference position, while in the measurement mode, the processing unit 12 calculates the position of the physiological signal measurement module 1 and the reference position according to the Y_N signal and the Z_N signal. The height difference ΔH of the position (altitude change parameter).

在获得高度变化参数ΔH后，处理单元12根据高度变化参数ΔH来补偿与当前脉波延迟时间PTT_N，以获得补偿脉波延迟时间PTT_C，如式(6)：After obtaining the height change parameter ΔH, the processing unit 12 compensates the current pulse wave delay time PTT_N according to the height change parameter ΔH to obtain the compensated pulse wave delay time PTT_C , as shown in formula (6):

${\mathrm{PTT}}_C={\mathrm{PTT}}_N-\left(\frac{\mathrm{\ΔH}}{0.54}\right)$式(6)${\mathrm{PTT}}_C={\mathrm{PTT}}_N-\left(\frac{\mathrm{\ΔH}}{0.54}\right)$ Formula (6)

在获得补偿脉波延迟时间PTT_C后，处理单元12自内存13读取在初始参数设定模式下获得的关系常数K，且根据补偿脉波延迟时间PTT_C与关系常数K来计算血压信号的收缩压值SBP_C，如式(7)：After obtaining the compensated pulse wave delay time PTT_C , the processing unit 12 reads the relationship constant K obtained in the initial parameter setting mode from the memory 13, and calculates the value of the blood pressure signal according to the compensated pulse wave delay time PTT_C and the relationship constant K Systolic blood pressure value SBP_C , such as formula (7):

SBP_C＝K[PTT_C]^-1    式(7)SBP_C ＝K[PTTT_C ]^-1 Formula (7)

在获得收缩压值SBP_C后，处理单元12自内存13读取初始舒张压参数DBP₀、初始收缩压参数SBP₀、及初始脉波延迟时间PTT₀，并根据缩压值SBP_C、初始舒张压参数DBP₀、初始收缩压参数SBP₀、初始脉波延迟时间PTT₀、以及补偿脉波延迟时间PTT_C来计算该血压信号中的舒张压值SBP_C，如式(8)After the systolic blood pressure value SBP_C is obtained, the processing unit 12 reads the initial diastolic blood pressure parameter DBP₀ , the initial systolic blood pressure parameter SBP₀ , and the initial pulse wave delay time PTT₀ from the memory 13, and according to the systolic blood pressure value_SBPC , the initial diastolic Blood pressure parameter DBP₀ , initial systolic blood pressure parameter SBP₀ , initial pulse wave delay time PTT₀ , and compensated pulse wave delay time PTT_C to calculate the diastolic blood pressure value SBP_C in the blood pressure signal, as shown in formula (8)

${\mathrm{<span><span>DBP</span>DBP</span>}}_{\mathrm{<span><span>C</span>C</span>}}<span><span>=</span>=</span>{\mathrm{<span><span>SBP</span>SBP</span>}}_{\mathrm{<span><span>C</span>C</span>}}<span><span>-</span>-</span><span><span>(</span>(</span>{\mathrm{<span><span>SBP</span>SBP</span>}}_{\mathrm{<span><span>0</span>0</span>}}<span><span>-</span>-</span>{\mathrm{<span><span>DBP</span>DBP</span>}}_{\mathrm{<span><span>0</span>0</span>}}<span><span>)</span>)</span><span><span>\&times;</span>\&times;</span>{<span><span>(</span>(</span>\frac{{\mathrm{<span><span>PTT</span>PTT</span>}}_{\mathrm{<span><span>0</span>0</span>}}}{{\mathrm{<span><span>PTT</span>PTT</span>}}_{\mathrm{<span><span>C</span>C</span>}}}<span><span>)</span>)</span>}^{\mathrm{<span><span>2</span>2</span>}}<span><span>-</span>-</span><span><span>-</span>-</span><span><span>-</span>-</span><span><span>(</span>(</span>\mathrm{<span><span>8</span>8</span>}<span><span>)</span>)</span>$

根据上述，在测量模式下，假使生理信号测量模块1的高度偏离参考位置的高度时，可通过姿势传感器11来计算此高度差ΔH(高度变化参数)，并透过高度变化参数ΔH来对当前脉波延迟时间PTT_N进行补偿，以进一步精准地计算收缩压值与舒张压值，避免因受测者下臂位置的变换所导致的血压值误差。According to the above, in the measurement mode, if the height of the physiological signal measurement module 1 deviates from the height of the reference position, the height difference ΔH (altitude change parameter) can be calculated by the posture sensor 11, and the current The pulse delay time PTT_N is compensated to further accurately calculate the systolic and diastolic blood pressure values, avoiding blood pressure value errors caused by changes in the position of the lower arm of the subject.

根据本发明的实施例，在生理信号测量模块1每次进行测量模式前，不需一定要进行初始参数设定模式。当内存13已储存了上述初始参数后，使用者可随时使用生理信号测量模块1的测量模式来测量血压。可定时或在必要时再将外部装置15连接至生理信号测量模块1，以进行初始参数设定模式。According to the embodiment of the present invention, before the physiological signal measurement module 1 performs the measurement mode every time, it is not necessary to perform the initial parameter setting mode. After the memory 13 has stored the above initial parameters, the user can use the measurement mode of the physiological signal measurement module 1 to measure blood pressure at any time. Theexternal device 15 can be connected to the physiological signal measurement module 1 regularly or when necessary to perform the initial parameter setting mode.

本发明的生理信号测量模块1可整合在个人数字助理、移动电话、数字相机、全球定位系统等移动式电子设备，以方便使用者能随身携带，以达到居家照护与实时自我生理测量的目的。The physiological signal measurement module 1 of the present invention can be integrated in mobile electronic devices such as personal digital assistants, mobile phones, digital cameras, global positioning systems, etc., so that users can carry it with them, so as to achieve the purpose of home care and real-time self-physiological measurement.

在本发明的实施例中，姿势感测单元11可包括加速度计、陀螺仪、或磁力计。此外，生理信号测量模块1可包括显示单元14，其可接收来自内存13的初始参数初始舒张压参数DBP₀、初始收缩压参数SBP₀、初始脉波延迟时间PTT₀、关系常数K、以及/或高度差H₀，也可接收由处理单元12所计算获得的高度变化参数ΔH、补偿脉波延迟时间PTT_C、收缩压值SBP_C、以及/或舒张压值SBP_C，并将接收的参数或信号透过显示面板140来显示给受测者。In an embodiment of the present invention, the posture sensing unit 11 may include an accelerometer, a gyroscope, or a magnetometer. In addition, the physiological signal measurement module 1 may include a display unit 14, which may receive the initial parameters from the memory 13, the initial diastolic pressure parameter DBP₀ , the initial systolic blood pressure parameter SBP₀ , the initial pulse wave delay time PTT₀ , the relationship constant K, and/or or altitude difference H₀ , can also receive the altitude change parameter ΔH calculated by the processing unit 12, the compensated pulse wave delay time PTT_C , the systolic blood pressure value_SBPC , and/or the diastolic blood pressure value_SBPC , and the received parameters Or the signal is displayed to the subject through thedisplay panel 140 .

在本发明的实施例中，光传感器24可与感测电极21-23中的一个结合，例如，光传感器24与感测电极23结合。在其它实施例中，光传感器24接近于感测电极23。In an embodiment of the present invention, thelight sensor 24 may be combined with one of the sensing electrodes 21 - 23 , for example, thelight sensor 24 is combined with thesensing electrode 23 . In other embodiments, thelight sensor 24 is close to thesensing electrode 23 .

图4是表示根据本发明实施例的生理信号测量流程图。参阅图1与2以及图4，首先，以生理信号测量模块11的感测电极21-23与光传感器24来测量受测者的心电信号ECG_N与脉搏信号PPG_N(步骤S40)。接着，处理单元12测量生理信号测量模块1与参考位置之间的高度，以产生高度变化参数ΔH(步骤S41)。处理单元12根据心电信号ECG_N与该脉搏信号PPG_N来计算当前脉波延迟时间PTT_N(步骤S42)。处理单元12根据高度变化参数ΔH来补偿当前脉波延迟时间PTT_N以获得补偿脉波延迟时间PTT_C，如式(6)(步骤S43)。由外部装置15提供初始舒张压参数DBP₀与初始收缩压参数SBP₀，且由内存13提供预先储存的初始脉波延迟时间PTT₀与以及关系常数K(步骤S44)。在此实施例中，外部装置15测量初始舒张压参数DBP₀初始收缩压参数SBP₀的操作，以及初始脉波延迟时间PTT₀与以及关系常数K的获得如前图1的实施例所述。处理单元12根据关系常数K与补偿脉波延迟时间PTT_C来计算血压信号的收缩压值SBP_C，如式(7)(步骤S45)。在获得收缩压值SBP_C之后，处理单元12根据收缩压值SBP_C、初始收缩压参数SBP₀、该初始舒张压参数DBP₀、初始脉波延迟时间PTT₀、与补偿脉波延迟时间PTT_C来计算血压信号的舒张压值DBP_C(步骤S46)。Fig. 4 is a flow chart showing a physiological signal measurement according to an embodiment of the present invention. Referring to FIGS. 1 and 2 and FIG. 4 , first, use the sensing electrodes 21 - 23 and thelight sensor 24 of the physiological signal measurement module 11 to measure the subject's ECG_N and pulse signal PPG_N (step S40 ). Next, the processing unit 12 measures the height between the physiological signal measurement module 1 and the reference position to generate a height change parameter ΔH (step S41 ). The processing unit 12 calculates the current pulse delay time PTT_N according to the electrocardiographic signal ECG_N and the pulse signal PPG_N (step S42 ). The processing unit 12 compensates the current pulse delay time PTT_N according to the height change parameter ΔH to obtain the compensated pulse delay time_PTTC , as shown in formula (6) (step S43 ). Theexternal device 15 provides the initial diastolic parameters DBP₀ and the initial systolic parameters SBP₀ , and the memory 13 provides the pre-stored initial pulse delay time PTT₀ and the relation constant K (step S44 ). In this embodiment, the operation of theexternal device 15 to measure the initial diastolic pressure parameter DBP₀ and the initial systolic blood pressure parameter SBP₀ , and the initial pulse wave delay time PTT₀ and the relation constant K are obtained as described in the previous embodiment of FIG. 1 . The processing unit 12 calculates the systolic blood pressure value SBP_C of the blood pressure signal according to the relationship constant K and the compensated pulse wave delay time PTT_C , as shown in formula (7) (step S45 ). After obtaining the systolic blood pressure value SBPC, the processing unit 12 according to the systolic blood pressure value SBP_C , the initial systolic blood pressure parameter SBP₀ ,_the initial diastolic blood pressure parameter DBP₀ , the initial pulse delay time PTT₀ , and the compensated pulse delay time PTT_C to calculate the diastolic pressure value_DBPC of the blood pressure signal (step S46).

在本发明的实施例中，步骤S44不限定在步骤S43之后，其可在执行步骤S45之前完成即可。In the embodiment of the present invention, step S44 is not limited to be performed after step S43, it can be completed before step S45 is executed.

虽然本发明已以较佳实施例揭露如上，然其并非用以限制本发明，任何熟悉此项技术的人员，在不脱离本发明的精神和范围内，当可做更动与润饰，因此本发明的保护范围当视后附的权利要求书所界定的范围为准。Although the present invention has been disclosed above with preferred embodiments, it is not intended to limit the present invention. Any person familiar with the art may make changes and modifications without departing from the spirit and scope of the present invention. Therefore, this The scope of protection of the invention should depend on the scope defined by the appended claims.

Claims (23)

Translated fromChinese

1.一种生理信号测量模块，其特征在于，包括：1. A physiological signal measurement module, characterized in that, comprising:一生理信号感测单元，用以测量一受测者的一心电信号与一脉搏信号；A physiological signal sensing unit, used to measure an electrocardiographic signal and a pulse signal of a subject;一姿势感测单元，用以感测该生理信号测量模块的位置，并输出多个位置信号；以及A posture sensing unit, used to sense the position of the physiological signal measurement module, and output a plurality of position signals; and一处理单元，接收该心电信号、该脉搏信号、与该多个位置信号，用以根据该多个位置信号来产生表示该生理信号测量模块与一参考位置间的高度差的一高度变化参数，该处理单元还根据该心电信号与该脉搏信号来计算一当前脉波延迟时间，且根据该高度变化参数来补偿该当前脉波延迟时间以获得一补偿脉波延迟时间，并根据该补偿脉波延迟时间来获得一血压信号。A processing unit receives the ECG signal, the pulse signal, and the plurality of position signals, and generates an altitude change parameter representing the altitude difference between the physiological signal measurement module and a reference position according to the plurality of position signals , the processing unit also calculates a current pulse wave delay time according to the ECG signal and the pulse signal, and compensates the current pulse wave delay time according to the altitude change parameter to obtain a compensated pulse wave delay time, and according to the compensation Delaying the pulse wave to obtain a blood pressure signal.2.根据权利要求1所述的生理信号测量模块，其特征在于，还包括一内存，用以储存一初始舒张压参数、一初始收缩压参数、一初始脉波延迟时间、以及一关系常数，其中，该关系常数是有关于该初始收缩压参数与该初始脉波延迟时间。2. The physiological signal measurement module according to claim 1, further comprising a memory for storing an initial diastolic pressure parameter, an initial systolic blood pressure parameter, an initial pulse wave delay time, and a relationship constant, Wherein, the relationship constant is related to the initial systolic pressure parameter and the initial pulse wave delay time.3.根据权利要求2所述的生理信号测量模块，其特征在于，该处理单元根据该关系常数与该补偿脉波延迟时间来计算该血压信号中的一收缩压值。3 . The physiological signal measurement module according to claim 2 , wherein the processing unit calculates a systolic blood pressure value in the blood pressure signal according to the relation constant and the compensated pulse wave delay time. 4 .4.根据权利要求3所述的生理信号测量模块，其特征在于，该处理单元根据SBP_C＝K[PTT_C]^-1来计算该收缩压值，SBP_C表示该收缩压值、K表示该关系常数、且PTT_C表示该补偿脉波延迟时间。4. The physiological signal measurement module according to claim 3, wherein the processing unit calculates the systolic blood pressure value according to_SBPC =K[_PTTC ]^-1 , SBP_C represents the systolic blood pressure value, K represents the The relationship constant, and_PTTC represents the compensation pulse delay time.5.根据权利要求4所述的生理信号测量模块，其特征在于，该关系常数等于该初始收缩压参数与该初始脉波延迟时间相乘的值。5 . The physiological signal measurement module according to claim 4 , wherein the relational constant is equal to a value obtained by multiplying the initial systolic blood pressure parameter by the initial pulse wave delay time.6.根据权利要求3所述的生理信号测量模块，其特征在于，该处理单元根据收缩压值、该初始收缩压参数、该初始舒张压参数、该初始脉波延迟时间、与该补偿脉波延迟时间来计算该血压信号中的一舒张压值。6. The physiological signal measurement module according to claim 3, wherein the processing unit is based on the systolic blood pressure value, the initial systolic blood pressure parameter, the initial diastolic blood pressure parameter, the initial pulse wave delay time, and the compensation pulse wave The delay time is used to calculate a diastolic pressure value in the blood pressure signal.7.根据权利要求6所述的生理信号测量模块，其特征在于，该处理单元根据

来计算该舒张压值，DBP_C表示该舒张压值，SBP_C表示该收缩压值，SBP₀表示该初始收缩压参数，DB_P0表示该初始舒张压参数，PTT₀表示该初始脉波延迟时间，且PTT_C表示该补偿脉波延迟时间。7. The physiological signal measurement module according to claim 6, wherein the processing unit is based on

To calculate the diastolic pressure value, DBP_C represents the diastolic pressure value, SBP_C represents the systolic pressure value, SBP₀ represents the initial systolic pressure parameter, DB_P0 represents the initial diastolic pressure parameter, PTT₀ represents the initial pulse wave delay time , and_PTTC represents the compensation pulse delay time.8.根据权利要求2所述的生理信号测量模块，其特征在于，储存在该内存的该初始舒张压参数与该初始收缩压参数由该生理信号测量模块的一外部装置所提供，且当该外部装置测量该初始舒张压参数与该初始收缩压参数时，该生理信号测量模块与该外部装置位置约等高。8. The physiological signal measurement module according to claim 2, wherein the initial diastolic pressure parameter and the initial systolic blood pressure parameter stored in the internal memory are provided by an external device of the physiological signal measurement module, and when the When the external device measures the initial diastolic pressure parameter and the initial systolic blood pressure parameter, the physiological signal measurement module is approximately at the same height as the external device.9.根据权利要求8所述的生理信号测量模块，其特征在于，当该外部装置测量该初始舒张压参数与该初始收缩压参数时，该生理信号感测单元同时测量该受测者的一初始心电信号与一初始脉搏信号，该处理单元根据该初始心电信号与该初始脉搏信号来计算该初始脉波延迟时间、以及根据该初始收缩压参数与该初始脉波延迟时间来计算该关系常数。9. The physiological signal measurement module according to claim 8, wherein when the external device measures the initial diastolic pressure parameter and the initial systolic blood pressure parameter, the physiological signal sensing unit simultaneously measures a an initial ECG signal and an initial pulse signal, the processing unit calculates the initial pulse wave delay time according to the initial ECG signal and the initial pulse wave signal, and calculates the initial pulse wave delay time according to the initial systolic blood pressure parameter and the initial pulse wave delay time relationship constant.10.根据权利要求9所述的生理信号测量模块，其特征在于，该处理单元将计算获得的该初始脉波延迟时间与该关系常数储存至该内存。10 . The physiological signal measurement module according to claim 9 , wherein the processing unit stores the calculated initial pulse wave delay time and the relation constant into the memory. 11 .11.根据权利要求1所述的生理信号测量模块，其特征在于，该参考位置位于与该受测者的心脏等高的位置。11 . The physiological signal measurement module according to claim 1 , wherein the reference position is located at the same height as the subject's heart.12.根据权利要求1所述的生理信号测量模块，其特征在于，还包括：12. The physiological signal measurement module according to claim 1, further comprising:三个感测电极，用以撷取该受测者的该心电信号；以及Three sensing electrodes are used to capture the ECG signal of the subject; and一光传感器，用以撷取该受测者的该脉搏信号。A light sensor is used to capture the pulse signal of the subject.13.根据权利要求12所述的生理信号测量模块，其特征在于，该光传感器与所述感测电极中的一个结合。13. The physiological signal measurement module according to claim 12, wherein the light sensor is combined with one of the sensing electrodes.14.根据权利要求1所述的生理信号测量模块，其特征在于，该生理信号感测单元透过该受测者的至少三只手指来测量该心电信号与该脉搏信号。14. The physiological signal measurement module according to claim 1, wherein the physiological signal sensing unit measures the ECG signal and the pulse signal through at least three fingers of the subject.15.根据权利要求1所述的生理信号测量模块，其特征在于，该生理信号测量模块可整合在一个人数字助理、一移动电话、一数字相机、或一全球定位系统。15. The physiological signal measurement module according to claim 1, wherein the physiological signal measurement module can be integrated into a personal digital assistant, a mobile phone, a digital camera, or a global positioning system.16.根据权利要求1所述的生理信号测量模块，其特征在于，该处理单元根据

来补偿该当前脉波延迟时间以获得该补偿脉波延迟时间，PTT_C表示该补偿脉波延迟时间，PTT_N表示该当前脉波延迟时间，且ΔH表示该高度变化参数。16. The physiological signal measurement module according to claim 1, wherein the processing unit is based on

To compensate the current pulse delay time to obtain the compensated pulse delay time, PTT_C represents the compensated pulse delay time, PTT_N represents the current pulse delay time, and ΔH represents the altitude change parameter.17.一种生理信号测量方法，其特征在于，包括：17. A method for measuring physiological signals, comprising:以一生理信号测量模块来测量一受测者的一心电信号与一脉搏信号；A physiological signal measurement module is used to measure an electrocardiographic signal and a pulse signal of a subject;测量该生理信号测量模块与一参考位置之间的高度，以产生一高度变化参数；Measuring the height between the physiological signal measuring module and a reference position to generate a height change parameter;根据该心电信号与该脉搏信号来计算一当前脉波延迟时间；calculating a current pulse wave delay time according to the ECG signal and the pulse signal;根据该高度变化参数来补偿该当前脉波延迟时间以获得一补偿脉波延迟时间；以及Compensating the current pulse delay time according to the altitude change parameter to obtain a compensated pulse delay time; and根据该补偿脉波延迟时间来获得一血压信号。A blood pressure signal is obtained according to the compensated pulse wave delay time.18.根据权利要求17所述的生理信号测量方法，其特征在于，还包括提供一初始舒张压参数、一初始收缩压参数、一初始脉波延迟时间、以及一关系常数，其中，该关系常数是有关于该初始收缩压参数与该初始脉波延迟时间。18. The physiological signal measurement method according to claim 17, further comprising providing an initial diastolic pressure parameter, an initial systolic blood pressure parameter, an initial pulse wave delay time, and a relationship constant, wherein the relationship constant is related to the initial systolic blood pressure parameter and the initial pulse wave delay time.19.根据权利要求18所述的生理信号测量方法，其特征在于，获得该血压信号的步骤还包括根据该关系常数与该补偿脉波延迟时间来计算该血压信号中的一收缩压值。19. The physiological signal measuring method according to claim 18, wherein the step of obtaining the blood pressure signal further comprises calculating a systolic blood pressure value in the blood pressure signal according to the relation constant and the compensated pulse wave delay time.20.根据权利要求19所述的生理信号测量方法，其特征在于，该收缩压值是根据SBP_C＝K[PTT_C]^-1来计算获得，SBP_C表示该收缩压值、PTT_C表示该补偿脉波延迟时间、且K表示该关系常数K＝SBP₀×PTT₀，而SBP₀表示该初始收缩压参数，且PTT₀表示该初始脉波延迟时间。20. The physiological signal measurement method according to claim 19, characterized in that, the systolic blood pressure value is calculated according to SBP_C =K[PTTC_C ]^-1 ,_SBPC represents the systolic blood pressure value, PTT_C represents the The pulse wave delay time is compensated, and K represents the relationship constant K=SBP₀ ×PTT₀ , while SBP₀ represents the initial systolic blood pressure parameter, and PTT₀ represents the initial pulse wave delay time.21.根据权利要求19所述的生理信号测量方法，其特征在于，获得该血压信号的步骤还包括根据收缩压值、该初始收缩压参数、该初始舒张压参数、该初始脉波延迟时间、与该补偿脉波延迟时间来计算该血压信号中的一舒张压值。21. The physiological signal measurement method according to claim 19, characterized in that the step of obtaining the blood pressure signal further comprises according to the systolic blood pressure value, the initial systolic blood pressure parameter, the initial diastolic blood pressure parameter, the initial pulse wave delay time, A diastolic pressure value in the blood pressure signal is calculated with the compensated pulse wave delay time.22.根据权利要求21所述的生理信号测量方法，其特征在于，该舒张压值是根据

来计算获得，DBP_C表示该舒张压值，SBP_C表示该收缩压值、SBP₀表示该初始收缩压参数、DBP₀表示该初始舒张压参数、PTT₀表示该初始脉波延迟时间、且PTT_C表示该补偿脉波延迟时间。22. The physiological signal measurement method according to claim 21, characterized in that the diastolic pressure value is based on

DBP_C represents the diastolic pressure value, SBP_C represents the systolic pressure value, SBP₀ represents the initial systolic pressure parameter, DBP₀ represents the initial diastolic pressure parameter, PTT₀ represents the initial pulse wave delay time, and PTT_C represents the compensation pulse delay time.23.根据权利要求17所述的生理信号测量方法，其特征在于，该当前脉波延迟时间是根据

来补偿以获得该补偿脉波延迟时间，PTT_C表示该补偿脉波延迟时间，PTT_N表示该当前脉波延迟时间，且ΔH表示该高度变化参数。23. The physiological signal measuring method according to claim 17, characterized in that, the current pulse wave delay time is based on

To obtain the compensated pulse delay time, PTT_C represents the compensated pulse delay time, PTT_N represents the current pulse delay time, and ΔH represents the altitude change parameter.

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