CN101614469A - A kind of full-automatic intelligent vacuum freeze dryer - Google Patents

Abstract

The present invention relates to a kind of full-automatic intelligent vacuum freeze dryer; comprise compressor; oil cooler; pneumatic or electrically operated valve; the pump head valve of vavuum pump and anti-oil pollution; filter; freeze drying box; condenser; the butterfly valve or the Mushroom valve of the band position feedback that freeze drying box and cold-trap connect; the temp probe of the goods and the cold spot of sterilizing in the freeze-drying casing; the cold and hot matchmaker's indirect heat exchange of shelf assembly system; judge heat-exchange system temperature and pressure switch; the Hydraulic Station of band pressure switch; it is characterized in that; select for use the automatic control intelligent element can judge whether the condition that to move automatically; judge; report to the police and the recording process route by continuing operation or voice-control alarm equipment; data; have power-off protection and memory function, the final vacuum freeze drying equipment of powering again can continue to continue operation according to FEOL.Advantage of the present invention is: guaranteed the rapidity of cold-trap coil pipe defrost, high efficiency; Under equal cleaning performance, saved the casing cost of manufacture, saved water consumption; Steam sterilizing F₀Value can freely be set according to actual conditions; Reach the purpose of fast cooling.

Description

A kind of full-automatic intelligent vacuum freeze dryer

Technical field

The present invention relates to a kind of full-automatic intelligent vacuum freeze dryer, but be used for the hydrous matter of freeze-drying or solution are freezed in advance at low temperatures, under vacuum environment, make the material dehydration obtain dry article then, belong to the vacuum freeze drier technical field.

Background technology

Vacuum freeze drying (abbreviation freeze dryer) but be exactly that the hydrous matter of freeze-drying or solution are freezed in advance at low temperatures, under vacuum environment, make the material dehydration obtain dry article then.This drying means with common dry, dry, boil dry, spray-drying compares many outstanding advantages with vacuum drying: the first, do not make protein, microorganism and so on produce sex change or lose biologos; The second, the loss of the nutritional labeling of volatile ingredient in the material and heated denaturalization is little; Three, the effect of microbial growth and enzyme almost can't be carried out, and can keep the original proterties of material best; Four, drying back form is constant substantially, is spongy open structure; Rehydration is easy, can promptly be reduced into original proterties; Five, dry under vacuum, oxygen is few, makes the material of easy oxidation obtain protection; Six, can remove in the material 95%～99% moisture, the goods long shelf-life.Just because of the existence of above-mentioned advantage, so freeze dryer is widely used in: pharmaceuticals industry, biological products; Biological tissue, microbiology class: animals and plants; Food industry; Chemical industry; Health care products and Chinese herbal medicine etc.

Present freeze dryer vacuum system comprises preceding case, condenser (cold-trap), vavuum pump group, small butterfly valve, pump head valve, vacuum gauge; Refrigeration system comprises the hydraulic system of compressor, oil eliminator, expansion valve, gas-liquid separator, cold and hot matchmaker's indirect heat exchange system (plate type heat exchanger and water condenser) and movable shelf.But there is following defective in present existing freeze dryer:

The freeze-dry process manual operation.Must manually-operated equipment in the freeze drying process process, thus the freeze-drying of goods finished.This just requires the freeze-drier operating personnel that higher professional knowledge and experience are arranged, and judges the technology key point; Operating personnel can not leave freeze-drier basically in addition; Thereby the difference of operator quality causes freeze-dry process difference, and different operating personnel's freeze-dried products performances is different, and the goods repeatability is not strong.

Manual water spray, immersion defrost.Manual operation has very big randomness, operates not necessarily standard; The aquation frost time is long, and the defrost effect is not so good; The water waste is more serious, the cost height.

Manually cleaning and cleaning pressure are poor, clean all operation by rule of thumb, i.e. the repeatability of process control is inconsistent; Cleaning performance can not guarantee that uniformity is poor, has increased validation difficulty; The rinse water consumption can't guarantee; Rinse water pressure can't guarantee, because the casing volume is big, according to manual cleaning method, nozzle quantity is arranged more, and other injection water spots of pharmaceutical factory are more relatively in addition, and pressure is not enough in the time of can causing the cleaning freeze-drier like this, and cleaning performance is poor.

Manual sterilization.Sterilization is operation by rule of thumb all, i.e. the repeatability of process control is inconsistent; Sterilization effect can not guarantee that uniformity is poor, has increased validation difficulty; Mistake can't be avoided; Documentation is many, and trackability is not strong.

Manually cool off flaggy and casing.Steam sterilizing rear box and flaggy temperature are quite high, and manually cooling velocity is slow, and weak effect, has increased the next group medicine inlet time; Conventional water leg cooling, cost is made higher, the manufacture craft more complicated.

Whether the casing air inlet can not guarantee the secondary pollution product, because the casing air intake filter all is installed in general production plant area basically, does not belong to gnotobasis, this for air intake filter whether intact quality for medicine cause close important.The method of tradition checking pneumatic filter is, after carrying out a collection of medicine, the pneumatic filter core removed verify, checking is carried out steam sterilizing after installing again, and this just has a very large risk, because the pneumatic filter core can not stand too big pressure differential, steam pressure might reach 0.3Mpa during steam sterilizing, if during steam sterilizing filter core is damaged, this may cause scrapping of this a collection of medicine, and loss will be very big.

Manually leakage rate test, having the people is mistake in computation; Can not provide the leakage rate nonconformance to report to the police automatically.

Summary of the invention

The vacuum freeze drier that the purpose of this invention is to provide a kind of full-automatic intelligent.

In order to achieve the above object, technical scheme of the present invention has provided a kind of full-automatic intelligent vacuum freeze dryer, comprise cold-trap, preceding case and compressor, before reaching, cold-trap is respectively equipped with cold-trap coil temperature probe and products temperature probe on the case, on the conduction oil port of export of preceding case and heat conductive oil inlet end, be respectively equipped with conduction oil outlet temperature probe and heat conductive oil inlet temp probe, it is characterized in that, the conduction oil port of export of preceding case connects bi-motor circulating pump and electric heater, on electric heater, be provided with temperature controller and pressure switch, on the port of export of electric heater, be connected with plate type heat exchanger, the heat conductive oil inlet of case before the port of export of plate type heat exchanger connects, between the high pressure chest of compressor and low-pressure cavity, be connected with high-low voltage relay, three ports of capacity regulating valve connect the high pressure chest of compressor respectively, middle chamber and the low-pressure cavity of pressing, oil eliminator is the high-pressure exhaust of pipeline connection compressor respectively, oil cooler and water condenser, oil cooler connects the middle pressure chamber of compressor, the low pressure air suction mouth of compressor connects gas-liquid separator, the gas-liquid separator pipeline connects plate type heat exchanger, one end of high-low pressure balanced valve and water condenser link to each other with pipeline between the oil eliminator, the other end of high-low pressure balanced valve connects the pipeline between motor cooling magnetic valve and gas-liquid separator and the plate type heat exchanger respectively, gas-liquid separator connects magnetic valve group and expansion valve group successively, the expansion valve group connects cold-trap and plate type heat exchanger respectively, between the low pressure air suction mouth of gas-liquid separator and compressor, be provided with the return-air temperature probe, between the middle pressure chamber of oil cooler and compressor, be provided with oil pressure difference relay.

Equipment provided by the invention makes Based Intelligent Control become possibility, is connected to PLC as long as will have the equipment of electricity input and electrical output signal, through the PLC logic control mode, again by the automatic operation of the computer realization that intelligent control software is installed.

The present invention is provided with position feed back signal on butterfly valve that preceding case and cold-trap connect or Mushroom valve, the small butterfly valve of band position feedback is set in the middle of vavuum pump and the cold-trap, cold-trap top arrangement pressure transmitter, water-ring vacuum pump is set, the general above-mentioned line program logic control that is configured into reaches the purpose of automatic defrosting.Guaranteed the rapidity of cold-trap coil pipe defrost, high efficiency.

The present invention is provided with the door switch signal, door forced locking device and feedback signal, cylinder latch and feedback signal, adopt the flaggy spray of specialty to set up meter, preceding box top is provided with rotation spray ball, the anti-slip of tamponade hydraulic cylinder is set near switch, is equipped with the Hydraulic Station of band pressure switch, thereby reach the automaticity of casing and flaggy cleaning.Under equal cleaning performance, saved the casing cost of manufacture, saved water consumption.

The present invention is provided with the door switch signal, door forced locking device and feedback signal, cylinder latch and feedback signal, pressure transmitter, electro connecting pressure gauge, safety valve, water-ring vacuum pump, steam admission main valve band position feed back signal, thus reach the automatic function of casing and cold-trap steam sterilizing sterilization.Steam sterilizing F₀Value can freely be set according to actual conditions.

The present invention is provided with motor cooling magnetic valve on the refrigeration system screw compressor, thereby has guaranteed behind the steam sterilizing when temperature is spent up to 120, can open the compressor flaggy that directly freezes, and reaches the purpose of fast cooling.

In sum, advantage of the present invention is: guaranteed the rapidity of cold-trap coil pipe defrost, high efficiency; Under equal cleaning performance, saved the casing cost of manufacture, saved water consumption; Steam sterilizing F₀Value can freely be set according to actual conditions; Reach the purpose of fast cooling.

Description of drawings

Fig. 1 is the schematic diagram of the vacuum freeze drying part of a kind of full-automatic intelligent vacuum freeze dryer provided by the invention;

Fig. 2 is the defrost of a kind of full-automatic intelligent vacuum freeze dryer provided by the invention, the schematic diagram of cleanse and disinfect part;

Fig. 3 is the connection diagram of the pneumatic operated valve used among the present invention;

Fig. 4 A is the side view that has the preceding case that sprays frame;

Fig. 4 B is the front view that has the preceding case that sprays frame;

Fig. 4 C is the vertical view that has the preceding case that sprays frame;

Fig. 4 D is the I part enlarged drawing among Fig. 4 B;

Fig. 5 is the freeze drying flow chart;

Fig. 6 is the automatic defrosting flow chart;

Fig. 7 is automatic cleaning process figure;

Fig. 8 is automatic steam sterilizing flow chart.

The specific embodiment

Specify the present invention below in conjunction with embodiment.

Embodiment

As shown in Figure 1, vacuum freeze drying schematic diagram partly for a kind of full-automatic intelligent vacuum freeze dryer provided by the invention, comprise cold-trap 19, precedingcase 22 and compressor 1, before reaching, cold-trap 19 is respectively equipped with cold-trapcoil temperature probe 24 andproducts temperature probe 20 on thecase 22, on the conduction oil port of export of precedingcase 22 and heat conductive oil inlet end, be respectively equipped with conduction oiloutlet temperature probe 23 and heat conductive oilinlet temp probe 21, the conduction oil port of export of precedingcase 22 connects bi-motor circulatingpump 7 andelectric heater 8, onelectric heater 8, be provided with temperature controller 9 andpressure switch 10, on the port of export ofelectric heater 8, be connected with platetype heat exchanger 11, the heat conductive oil inlet ofcase 22 before the port of export of platetype heat exchanger 11 connects, between the high pressure chest of compressor 1 and low-pressure cavity, be connected with high-low voltage relay 18, three ports ofcapacity regulating valve 2 connect the high pressure chest of compressor 1 respectively, middle chamber and the low-pressure cavity of pressing,oil eliminator 17 is the high-pressure exhaust of pipeline connection compressor 1 respectively, oil cooler 6 and water condenser 5, oil cooler 6 connects the middle pressure chamber of compressor 1, the low pressure air suction mouth of compressor 1 connects gas-liquid separator 13, gas-liquid separator 13 pipelines connect platetype heat exchanger 11, one end of high-low pressure balanced valve 66 and water condenser 5 link to each other with pipeline between theoil eliminator 17, the other end of high-low pressure balanced valve 66 connects the pipeline between motor coolingmagnetic valve 12 and gas-liquid separator 13 and the platetype heat exchanger 11 respectively, gas-liquid separator 13 connects magnetic valve group 14 andexpansion valve group 16 successively,expansion valve group 16 connects cold-trap 19 and platetype heat exchanger 11 respectively, magnetic valve group 14 can be divided into four magnetic valves as shown in Figure 1, the i.e. first magnetic valve SV21, the second magnetic valve SV31, the 3rd magnetic valve SV1 and the 4th magnetic valve SV11, andexpansion valve group 16 is divided into four too, the i.e. first expansion valve TEV31, the second expansion valve TEV41, the 3rd expansion valve TEV11 and the 4th expansion valve TEV21, the first magnetic valve SV21 connects and is in parallel with the second magnetic valve SV31 that connects and the second expansion valve TEV41 behind the first expansion valve TEV31, one end of this shunt circuit connects cold-trap 19, be connected platetype heat exchanger 11 after the 3rd magnetic valve SV1 and the 3rd expansion valve TEV11 series connection, the 4th magnetic valve SV11 connects and connects the another one plate type heat exchanger behind the 4th expansion valve TEV21, between the low pressure air suction mouth of gas-liquid separator 13 and compressor 1, be provided with return-air temperature probe 15, between the middle pressure chamber of oil cooler 6 and compressor 1, be provided with oilpressure difference relay 3.

As shown in Figure 2, defrost for a kind of full-automatic intelligent vacuum freeze dryer provided by the invention, the schematic diagram of cleanse and disinfect part, on cold-trap 19, be respectively equipped with the cold-point temperature probe 29 of cold-trap, the Mushroom valvehydraulic cylinder 42 of control Mushroom valve switch, cold-trap pressure transmitter 43 and cold-trap safety valve 44, on Mushroom valvehydraulic cylinder 42, be provided withnear switch 40, cold-trap 19 connects vavuum pump group 28 by small butterfly valve FV2, total draining valve FV33, valve FV34 and water ring pump 30 are in parallel between steam, one end of this shunt circuit connects cold-trap 19 by draining valve FV27, be respectively equipped with the casing flaggy on sidewall before described in thecase 22 and the top andclean spray frame 59 and casingcleaning spray ball 60, precedingcase safety valve 62, electroconnecting pressure gauge 45, precedingcase pressure transmitter 48, vacuum gauge 49 and before an end of the cold-point temperature probe 31 of case stretch into before in thecase 22, vacuum gauge 49 is a Pirani-ga(u)ge, on the chamber door of precedingcase 22, be provided with chamber door nearswitch 32, tamponadehydraulic cylinder 46 is located on the precedingcase 22, on tamponadehydraulic cylinder 46, be provided with anti-slip BALLUFF nearswitch 47, tamponadehydraulic cylinder 46 links to each other with theHydraulic Station 51 ofband pressure switch 50, the import that casing cleansspray ball 60 links to each other by the import of pipeline with grade onefilter 37, the end of pure steam main valve FV18 and rinse water main valve FV19 is connected on this pipeline, the two ends of grade onefilter 37 connect air inlet main valve FV9 andsecondary filter 38 respectively, on air inlet main valve FV9, be parallel with aeration valve FV13, nitrogen intake valve 25 be connected connecting altogether a little and the online integrity detection device 34 of filter of air inlet main valve FV9 and aeration valve FV13 respectively after an end that advances pure air valve 65 connects altogether, filter integrity checkout gear 63 connects grade onefilter 37 andsecondary filter 38 simultaneously, filter integrity checkout gear 63 is important protective ring joint, can guarantee the aseptic of medicine conscientiously, on grade onefilter 37 andsecondary filter 38, be connected with draining steam needle-valve in parallel 26 and draining steam valve FV83 separately, one end of filter water intakingvalve 36 is connected between air inlet main valve FV9 and the grade onefilter 37, the other end of filter water intakingvalve 36 is connected between grade onefilter 37 and thesecondary filter 38,case 22 before the port of export ofsecondary filter 38 connects.As shown in Figure 3, small butterfly valve FV2, air inlet main valve FV9, aeration valve FV13, pure steam main valve FV18, rinse water main valve FV19, draining valve FV27, total draining valve FV33, valve FV34 is connected atmospheric pressure relay 53 with draining steam valve FV83 between steam, because above-mentioned valve all is an operated pneumatic valve, therefore need to connect atmospheric pressure relay 53 and provide normal air pressure, could make above-mentioned valve operate as normal, simultaneously, for the unlatching and closure of controlling these valves by PLC, all be connected with a magnetic valve on each valve, external PLC controls the unlatching of above-mentioned valve with closed by magnetic valve.

Shown in Fig. 4 A to Fig. 4 D, for having the structural representation of the preceding case that sprays frame, by these figure as can be seen, the casing flaggy cleansspray frame 59 and comprises straight tube 1-1, on straight tube 1-1, be provided with successively from the bottom to top with described before the corresponding transverse tube 1-3 in flaggy 1-2 position in thecase 22, on transverse tube 1-3, be provided with at least one fan type nozzle 1-4.

As Fig. 5 is the freeze drying flow chart, cryodesiccated as known in the figure roughly process is: equipment enters the automatic freeze-drying stage, 7 startups of bi-motor circulating pump (protect bypressure switch 10 by circulatory system pressure, one end of the normally-closed contact ofpressure switch 10 connects the PLC other end and then connects circulation line inside, the pressure size is not in setting range, the normally-closed contact ofpressure switch 10 disconnects, bi-motor circulatingpump 7 can automatically switch to another motor by a motor, and report to the police), compressor 1 starts that (what must satisfy the requirements before the compressor start is thatwater pressure relay 4 and atmospheric pressure relay 53 are at normally-pressured neighbor, because all valves all are operated pneumatic valve, necessarily required atmospheric pressure like this, can guarantee that so just operated pneumatic valve can open, therefore require atmospheric pressure relay 53 in normally-pressured neighbor); Start the back and carry out the automatic protection and the warning of compressor by high-low voltage relay 18 and oilpressure difference relay 3; cold-producing medium is extruded through gs-oil separator 17 to water condenser 5 by compressor 1 high pressure again, again by water condenser 5 by plate type heat exchanger to magnetic valve group 14 (the 3rd magnetic valve SV1 and the 4th magnetic valve SV11 unlatching at this moment).After being come out by gs-oil separator 17, cold-producing medium also have a subbranch to arrive gas-liquid separator 13 again to high-low pressure balanced valve 66 by gs-oil separator 17; though seeing it is the branch two-way; but working control is; during operate as normal, high-low pressure balanced valve 66 cuts out, medicine freeze-drying by the time finish magnetic valve group 14 close close with compressor after; there is PLC logic control relation control high-low pressure balanced valve 66 to open; realize height nip cold-producing medium balance, after preventing to shut down, the cold-producing medium hydrops.Cold-producing medium arrivesexpansion valve group 16 through magnetic valve group 14 backs, gets back to gas-liquid separator 13 by platetype heat exchanger 11 again, by compressor 1 thing in the gas-liquid separator 13 is drawn into the compressor low-pressure end, through the compressor internal compression, realizes continuous circularly cooling.According to freeze-drying curve, after heat conductive oilinlet temp probe 21 reaches design temperature, the first magnetic valve SV21 in the magnetic valve group 14 and the second magnetic valve SV31 open, but the 3rd magnetic valve SV1 and the 4th magnetic valve SV11 can be according to heat conductive oilinlet temp probe 21 in the freeze-drying curve and the first magnetic valve SV21 and second magnetic valve SV31 automatic switchovers; After cold-trap coilpipe temperature probe 24 temperature reach setting value, vavuum pump group 28 among Fig. 2 starts, behind setting-up time, small butterfly valve FV2 opens, behind setting-up time,Mushroom valve 42 opens that (top two times are to set according to the freeze-drying curve parameter in the control system interface, can set some freeze-drying curves by this control system, thereby satisfy the needs of the different freeze-dry process of client, after the setup parameter, behind setting-up time, by the magnetic valve SV602 in the PLC outputsignal control chart 3, magnetic valve SV602 gets, atmospheric pressure is opened Pneumatic butterfly valve FV2 by tracheae, in like manner, behind setting-up time, by theHydraulic Station 51 in the PLC output signal control chart 2.OpenMushroom valve 42, close small butterfly valve FV2 earlier, because when vavuum pump has just started, less stable is gone back in the motor operation, if at this moment all small butterfly valve FV2 is opened, can increase the load of vaccum pump motor, burn out motor, because the vacuum freeze sealing requirements is very high, after small butterfly valve FV2 opens, vavuum pump is wanted earlier cold-trap to be vacuumized, after being extracted into a period of time, everyvalve 42, the external and internal pressure ofcase 22 is poor before forming like this, passes through pressure differential in opening so again, can guarantee that like this chamber door and casing well seal), according to the temperature value of freeze-drying curve and setting,electric heater unit 8 starts beginning lyophilization for the first time, then according to freeze-drying curve subsequently, lyophilization for the second time, detect the casing internal pressure by vacuum gauge 49 and change the automatic judgement of finishing the freeze-drying terminal point, air inlet main valve FV9 opens afterwards, fills nitrogen (guaranteeing that medicine does not contact oxygen), automatically (pressure switch pressure changes in tamponade subsequently, judge tamponade Position of Hydraulic Cylinder lower limit, and can freely set the tamponade number of times), follow compressor 1, circulatingpump 7, small butterfly valve FV2, vavuum pump group 28 is closed successively, last air inlet main valve 35 is opened, return to atmospheric pressure in the casing, the door of unpacking, goods outlet.

Automatically in the freeze-drying process, intelligent being mainly reflected in: one, on the compressor start condition judgment, for examplewater pressure relay 4, atmospheric pressure relay 53 etc.; Two, compressor protection aspect, for example high-low voltage relay 18, oilpressure difference relay 3 etc.; Three, capacity adjusting valve 2 (triple valve) can be according to the compressor operating situation, and automaticallying switch, (after the compressor unlatching, the high pressure ofcapacity adjusting valve 2 is connected, the load of motor when in time reducing the compressor unlatching, behind the compressor working stability, other one the tunnel connects operate as normal); Four, compressor electric motor coolingmagnetic valve 12 can be according to the suction temperature automatic cooling protection motor of the 15 setting ranges operating mode (suction temperatures that suction temperature probe 15 is measured of popping one's head in, by the TC module converts that is input among the PLC is analog quantity, carry out programming in logic output switching value, thereby reach the purpose of logic control); Five, doubleend circulating pump 7 can be according to automaticallying switch between two motors of operating pressure; Six,electrical heating 8 heating-up temperatures can realize PID control; Seven, vacuum can be controlled or the like automatically in the freeze-drying casing 22.The full-automatic intelligent freeze dryer is the parts by specialized function on the equipment, and input signal carries out programming in logic in PLC inside in PLC, and output switching value signal carries out automation, intelligentized control, realizes the purpose of fully-automatic intelligent.

As shown in Figure 6, be the automatic defrosting flow chart, this process can simply be described as: behind the preceding case goods outlet or simultaneously, both can enter the automatic defrosting stage, at first judge the pass signal ofMushroom valve 40, atmospheric pressure relay 53,water pressure relay 4 signals and small butterfly valve FV2 close signal, judge cold-trap 19 internal pressures bypressure transmitter 43 subsequently, water ring pump 30 is evacuated down to setting value, steam main valve FV18 opens (band feedback signal) and water inlet vapour valve sets is opened afterwards, judge cold-trap 19 internal pressures bypressure transmitter 43, surpass setting pressure, pneumatic draining vapour valve sets 56 is opened, and row's condensed water (can set arbitrarily by water discharge time, by the total draining steam valve of electro connectingpressure gauge 45 controls),coil temperature probe 24, temperature at discharging condensate 29 temperature of popping one's head in reach the defrost of setting value back simultaneously and finish, and pneumatic draining vapour valve sets 56 is opened, draining vapour to cold-trap 19 internal pressures to setting value, water ring pump 30 vacuumizes cold-trap 19 vaporizations dry, to setting-up time, the dry end, defrost finishes automatically.

As shown in Figure 7, be automatic cleaning process figure, automatically case 22 or rear cabinet cold-trap 19 or precedingcase 22 and rear cabinet cold-trap 19 cleaned simultaneously before cleaning can be selected to clean separately, be that this process of example can simply be described as only: close chamber door with case before the independent cleaning, automaticdoor lock device 58 inserts and providesauto lock signal 57, judge that Mushroomvalve 40 closes signal, atmospheric pressure relay 53,water pressure relay 4 signals and door close signal nearswitch 32, water ring pump 30 is evacuated down to setting value subsequently, cylinder latch group 54 is inserted and is provided and compresses chamber door sets of signals 61, automaticdoor lock device 58 is regained,auto lock signal 57 is opened, air inlet main valve FV9 opens, be pressed onto setting value again, pneumatic water inlet steam valve door FV19 opens, pneumatic draining steam valve door FV27 opens the back time-delay at pneumatic water inlet steam valve door FV19 and opens, casing cleansrotation spray ball 60 and cleans casing to setting-up time, switchflaggy spray frame 59, spray frame nozzle is improved to the fan type by pyramid type, flaggy is improved to dynamic cleaning by static, whenspray frame 59 cleans, flaggy is by tamponadehydraulic cylinder 46 and HydraulicStation pressure switch 50, judge flaggy upper-lower position position, the cycle of carrying out moves up and down, setting cycle and scavenging period arbitrarily, the setting cleaning frequency closes to the pneumatic water inlet steam valve door FV19 in back,case 22 pressure were to setting value beforepressure transmitter 48 was judged, the draining main valve closes, vaporization dry (water ring pump 30 is evacuated down to setting-up time), cylinder latch group 54 is extracted, air inlet main valve FV9 opens, and returns to atmospheric pressure in the casing, cleans automatically and finishes.

As shown in Figure 8; be automatic steam sterilizing flow chart; automatically steam sterilizing can be selected the precedingcase 22 of sterilization separately or rear cabinet cold-trap 19 or precedingcase 22 and 19 while of rear cabinet cold-trap steam sterilizing; now rear cabinet while steam sterilizing is introduced autosterilization technology in the past; its process is: enter autosterilization master interface; case while steam sterilizing before and after selecting; close chamber door; automaticdoor lock device 58 inserts and providesauto lock signal 57;judgement Mushroom valve 40 is opened signal; atmospheric pressure relay 53;water pressure relay 4 signals; door closes nearswitch 32 and small butterfly valve FV2 closes signal; water ring pump 30 is evacuated down to setting value; cylinder latch group 54 is inserted and is compressed chamber door sets of signals 61; automaticdoor lock device 58 is regained;auto lock signal 57 is opened; pneumatic water inlet steam valve door FV18 opens; precedingcase pressure transmitter 48 and cold-trap pressure transmitter 43 are to setting pressure; pneumatic water inlet steam valve door FV18 closes; water ring pump 30 is evacuated down to setting value; pneumatic water inlet steam valve door FV18 opens; precedingcase pressure transmitter 48 and cold-trap pressure transmitter 43 are to setting pressure; and then open water ring pump 30 and vacuumize; recyclingly advance steam; vacuumize and to extract incoagulable gas in the casing out casing; reach best sterilization effect; cycle-index can be set arbitrarily; if cycle sets time is counted to and precedingcase 22 and rear cabinet cold-trap 19 pressure (are no more than the design of pressure vessels scope in order to guarantee the casing internal pressure to setting the pressure of sterilizing; the triple protection function is adopted in design; precedingcase pressure transmitter 48 and cold-trap pressure transmitter 43 are to setting pressure; pneumatic water inlet steam valve door FV18 closes; if steam pressure also continues to rise in the casing; electroconnecting pressure gauge 45 can be opened total draining steam valve FV33; if steam pressure also continues to rise in the casing; precedingcase safety valve 62 and cold-trap 44 safety valves can be opened; carry out pressure release; their pressure is set from low to high and is set), judge temperature and write down F according to the cold-point temperature probe 29 of the cold-point temperature probe 31 of preceding case and cold-trap₀Value (F₀Value can be set arbitrarily), F₀Value arrives the pneumatic water inlet steam valve door FV18 in setting value back and closes, total draining steam valve FV33 opens the pressure release of row's steam,case 22 and cold-trap 19 pressure were to setting value before precedingcase pressure transmitter 48 and cold-trap pressure transmitter 43 were judged, total draining steam valve FV33 closes, vaporization dry (water ring pump 30 is evacuated down to setting-up time), cylinder latch group 54 is extracted, and air inlet main valve 35 is opened, return to atmospheric pressure in the casing, autosterilization finishes.

Temperature when autosterilization finishes the back owing to sterilization will reach 121 degree, so the temperature of sterilization rear box is still very high, if be the words of normal cooling, cool time will be very long, be certain to influence production cycle and output, therefore, reach this function by programme-control and process modification.This process is: autosterilization finishes, close chamber door, compressor 1 starts, the 3rd magnetic valve SV1 and the 4th magnetic valve SV11 in the magnetic valve group 14 leave, behind setting-up time, the 3rd magnetic valve SV1 and the 4th magnetic valve SV11 close, circulatingpump 7 leaves, behind setting-up time, circulatingpump 7 closes, the 3rd magnetic valve SV1 and the 4th magnetic valve SV11 open, behind setting-up time, the 3rd magnetic valve SV1 and the 4th magnetic valve SV11 close, circulatingpump 7 leaves, behind setting-up time, circulatingpump 7 closes, and then open the 3rd magnetic valve SV1 and the 4th magnetic valve SV11, refrigeration system is cooled off the circulatory system is local by the 3rd magnetic valve SV1 and the 4th magnetic valve SV11 switch, the ON cycle pump carries out the flaggy cooling then, after running to setting-up time, circulatory systeminlet temperature probe 21 is behind design temperature, and the 3rd magnetic valve SV1 and the 4th magnetic valve SV11 open, and circulatingpump 7 leaves, flaggy is cooled off fast, circulatory systeminlet temperature probe 21 is behind design temperature, and the flaggy cooling finishes, and switching solenoid valve group 14 is opened win magnetic valve SV21 and the second magnetic valve SV31, cooling cold-trap 19,coil temperature probe 24 is behind design temperature, and the first magnetic valve SV21 in the magnetic valve group 14 and the second magnetic valve SV31 close, and cooling finishes.

In automatic cooling procedure; intelligent being mainly reflected in order to protect the security of compressor 1, in cooling procedure, compressor 1 suction temperature is carried out constantly and is detected; when suction temperature is too high; suction temperature probe 15 (set bound, when at temperature upper limit, open bymagnetic valve 12; when at lowest temperature;magnetic valve 12 cuts out) can cool offmagnetic valve 12 by the control compressor, compression motor is carried out the hydrojet cooling, the protection compressor.

Online integrity detection system 34 major functions of filter have, and one, can be simultaneously and precedingcase 22 or carry out the moise-heat sterilization sterilization separately, two, can onlinely carry out filter integrity and detect, three, carry out online vaporization drying.

After installing grade onefilter 37 andsecondary filter 38, because integrity detection system is positioned at normal areas, filter, after installing, must carry out to filter clean gas behind the steam sterilizing to it, could guarantee to prevent that secondary pollution is (if cartridge carries bacterium, after aseptic air is by the filter core that bacterium is arranged, air may be contaminated, there is the gas of bacterium to enter casing meeting polluted product), behind the steam sterilizing, because clean steam has certain pressure, and filter core can not bear elevated pressures, so verify the integrality of the cartridge after the sterilization, the design's theory adopts latest model WIT (water immersion method), filter water intakingvalve 36 is opened, and water enters in the filter head housings, because filter core is the hydrophobicity material, water can not pass through filter core, water is closed filter water intakingvalve 36 after immersing fully to filter core, opens the integrity detection instrument, automatically detect, the integrity detection instrument can automatic testing result and print record, detect qualified after, open water ring pump 30 by the pipeline drying of vaporizing, behind setting-up time, water pump cuts out, and detects and finishes, and waits the production of next group medicine.

Claims (3)

1. full-automatic intelligent vacuum freeze dryer, comprise cold-trap (19), preceding case (22) and compressor (1), before reaching, cold-trap (19) is respectively equipped with cold-trap coil temperature probe (24) and products temperature probe (20) on the case (22), on the conduction oil port of export of preceding case (22) and heat conductive oil inlet end, be respectively equipped with conduction oil outlet temperature probe (23) and heat conductive oil inlet temp probe (21), it is characterized in that, the conduction oil port of export of preceding case (22) connects bi-motor circulating pump (7) and electric heater (8), on electric heater (8), be provided with temperature controller (9) and pressure switch (10), on the port of export of electric heater (8), be connected with plate type heat exchanger (11), the heat conductive oil inlet of case (22) before the port of export of plate type heat exchanger (11) connects, between the high pressure chest of compressor (1) and low-pressure cavity, be connected with high-low voltage relay (18), three ports of capacity regulating valve (2) connect the high pressure chest of compressor (1) respectively, middle chamber and the low-pressure cavity of pressing, oil eliminator (17) is the high-pressure exhaust of pipeline connection compressor (1) respectively, oil cooler (6) and water condenser (5), oil cooler (6) and water condenser (5) connect the middle pressure chamber of compressor (1) respectively, the low pressure air suction mouth of compressor (1) connects gas-liquid separator (13), gas-liquid separator (13) pipeline connects plate type heat exchanger (11), one end of high-low pressure balanced valve (66) and water condenser (5) link to each other with pipeline between the oil eliminator (17), the other end of high-low pressure balanced valve (66) connects the pipeline between motor cooling magnetic valve (12) and gas-liquid separator (13) and the plate type heat exchanger (11) respectively, gas-liquid separator (13) connects magnetic valve group (14) and expansion valve group (16) successively, expansion valve group (16) connects cold-trap (19) and plate type heat exchanger (11) respectively, between the low pressure air suction mouth of gas-liquid separator (13) and compressor (1), be provided with return-air temperature probe (15), between the middle pressure chamber of oil cooler (6) and compressor (1), be provided with oil pressure difference relay (3).

2. a kind of full-automatic intelligent vacuum freeze dryer as claimed in claim 1, it is characterized in that, on described cold-trap (19), be respectively equipped with the cold-point temperature probe of cold-trap (29), the Mushroom valve hydraulic cylinder (42) of control Mushroom valve switch, cold-trap pressure transmitter (43) and cold-trap safety valve (44), on Mushroom valve hydraulic cylinder (42), be provided with near switch (40), cold-trap (19) connects vavuum pump group (28) by small butterfly valve (FV2), total draining valve (FV33), valve between steam (FV34) is in parallel with water ring pump (30), one end of this shunt circuit connects cold-trap (19) by draining valve (FV27), be respectively equipped with the casing flaggy on sidewall in the case before described (22) and the top and clean spray frame (59) and casing cleaning spray ball (60), preceding case safety valve (62), electro connecting pressure gauge (45), preceding case pressure transmitter (48), vacuum gauge (49) and before an end of the cold-point temperature probe of case (31) stretch in the preceding case (22), on the chamber door of preceding case (22), be provided with chamber door near switch (32), tamponade hydraulic cylinder (46) is located on the preceding case (22), on tamponade hydraulic cylinder (46), be provided with anti-slip BALLUFF near switch (47), tamponade hydraulic cylinder (46) links to each other with the Hydraulic Station (51) of band pressure switch (50), the import that casing cleans spray ball (60) links to each other by the import of pipeline with grade one filter (37), one end of pure steam main valve (FV18) and rinse water main valve (FV19) is connected on this pipeline, the two ends of grade one filter (37) connect air inlet main valve (FV9) and secondary filter (38) respectively, on air inlet main valve (FV9), be parallel with aeration valve (FV13), nitrogen intake valve (25) be connected connecting altogether a little and filter integrity checkout gear (63) of air inlet main valve (FV9) and aeration valve (FV13) respectively after an end that advances pure air valve (65) connects altogether, filter integrity checkout gear (63) connects grade one filter (37) and secondary filter (38) simultaneously, on grade one filter (37) and secondary filter (38), be connected with draining steam needle-valve (26) in parallel and draining steam valve (FV83) separately, one end of filter water intaking valve (36) is connected between air inlet main valve (FV9) and the grade one filter (37), the other end of filter water intaking valve (36) is connected between grade one filter (37) and the secondary filter (38), case (22) before the port of export of secondary filter (38) connects, small butterfly valve (FV2), air inlet main valve (FV9), aeration valve (FV13), pure steam main valve (FV18), rinse water main valve (FV19), draining valve (FV27), total draining valve (FV33), valve between steam (FV34) is connected atmospheric pressure relay (53) with draining steam valve (FV83).

3. a kind of full-automatic intelligent vacuum freeze dryer as claimed in claim 2, it is characterized in that, described casing flaggy cleans spray frame (59) and comprises straight tube (1-1), on straight tube (1-1), be provided with successively from the bottom to top with described before the corresponding transverse tube in flaggy (1-2) position (1-3) in the case (22), on transverse tube (1-3), be provided with at least one fan type nozzle (1-4).

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