CN101584330A - Propineb and azoxystrobin-containing antiseptic composition - Google Patents

Abstract

The invention discloses a propineb and azoxystrobin-containing antiseptic composition, which comprises propineb and azoxystrobin in mass percent ratio of 5-80:40-1 and can be made into a wettable powder, water dispersible granules or a suspending agent. The compound antiseptic composition can be used for preventing and controlling diseases of fruit trees and vegetables, particularly tomato early blight, cucumber downy mildew, altemaria mali Roberts and sigatoka.

Description

A kind of bactericidal composition that contains Propineb and Fluoxastrobin

Technical field

The invention belongs to technical field of pesticide, relate to a kind of bactericidal composition that contains Propineb and azoxystrobin compound with synergistic effect.

Technical background

Propineb (propineb) belongs to dithiocarbamate fungicide, and pure product are the white powder of special odor slightly.Stable under drying condition, under moist, acid, alkali condition, decompose.Molecular formula: (C₅H₈N₂S₄Zn)_x, chemical name: acrylic bisdithiocarbamic zinc.Propineb is a kind of protection type bactericide of quick-acting long residual wide spectrums; its bactericidal mechanism is unfixing; site of action is many; the main oxidation that suppresses pyruvic acid in the cause of disease thalline; morning, late blight to downy mildew, tomato and the potato of crops such as vegetables, grape, tobacco and lupulus all have good protective effect, and the disease of powdery mildew, rust and Botrytis is also had certain inhibitory action.

Fluoxastrobin (Azoxystorbin) is a kind of brand-new β methoxy acrylic acid lipid bactericide, is by Syngenta Co.,Ltd's development product.Former medicine outward appearance is the light brown solid, no special odor.Molecular formula: C₂₂H₁₇N₃O₅, chemical name: (E)-2-{2-[6 (2-cyano-benzene oxygen) pyrimidine-4-base oxygen] phenyl }-the 3-methoxy acrylate.Fluoxastrobin belongs to the mitochondrial respiratory inhibitor, has protection, treats and root out triple function, destroys synthetic its loss of life power that makes of energy of bacterium by the respiration that suppresses germ.Fluoxastrobin has good crop safety and very outstanding Environmental compatibility.Efficiently, wide spectrum, nearly all mycota (Ascomycotina, Basidiomycotina, Mastigomycotina and Deuteromycotina) disease such as powdery mildew, rust, glume blight, net blotch, downy mildew, rice blast etc. are all had good activity.Can be used for cauline leaf spraying, seed treatment, also can carry out soil treatment, be mainly used in cereal, paddy rice, peanut, grape, potato, fruit tree, vegetables, coffee etc.

No matter be Propineb or Fluoxastrobin, the same with many bactericide efficient, wide spectrum.Long-term a large amount of single use all can make disease develop immunity to drugs, and increases usage amount, strengthens the control cost, produces a series of environmental problem simultaneously.A way that addresses this problem is carried out composite with regard to the bactericide that is to use the different mechanisms of action, this method can not only reduce the agricultural chemicals usage amount, improves the practical function effect, can also delay viral drug-fast generation.

Composite about between Propineb and these two kinds of active ingredients of Fluoxastrobin do not see relevant report at present at home and abroad as yet.These two kinds of compositions carry out composite, have certain novelty and uniqueness.

Summary of the invention

The objective of the invention is provides the bactericidal composition with synergistic function that contains Propineb and Fluoxastrobin that a kind of bactericidal range is wide, use cost is low, practical effect is good at technical problem mentioned above.

The present invention is achieved through the following technical solutions:

A kind of bactericidal composition that contains Propineb and Fluoxastrobin is characterized in that: Propineb and Fluoxastrobin percentage by weight are 5～80: 40～1.

The described bactericidal composition that contains Propineb and Fluoxastrobin, preferably the active component percentage by weight after is 10～70: 30～5.

The described bactericidal composition that contains Propineb and Fluoxastrobin, the effective active composition adds auxiliary agent and excipients is made wetting powder, water dispersible granules, suspending agent.

Described auxiliary agent and excipients are selected from: one or more in dispersant, wetting agent, disintegrant, antifreeze, defoamer, thickener, filler or the deionized water.

Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, fatty acid glyceride polyoxyethylene.

Described wetting agent is selected from: one or more in lauryl sodium sulfate, DBSA, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.

Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, the sodium bicarbonate.

Described antifreeze is selected from: one or more in ethylene glycol, propane diols, the glycerine.

Described defoamer is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.

Described thickener is selected from: one or more in xanthan gum, CMC, hydroxyethylcellulose, methylcellulose, Magnesiumaluminumsilicate, polyvinyl alcohol, the polyethylene glycol.

Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.

The bactericidal composition that the present invention contains Propineb and Fluoxastrobin is mainly used in prevents and treats early blight of tomato, cucumber downy mildew, alternaria leaf spot of apple, sigatoka.

Beneficial effect of the present invention: the used Propineb of (1) the present invention is a dithiocarbamate fungicide, and Fluoxastrobin is a β methoxy acrylic acid lipid bactericide; Both are mixed mutually and can produce conflict, have reduced dosage, have enlarged fungicidal spectrum, have reduced cost.(2) the present invention makes up drug effect and uses each composition drug effect height than independent, and scope of application increase, is applicable to control cereal class, fruit tree and vegetable crop disease.Especially the disease of crops such as tomato, cucumber, apple, banana.

Embodiment

To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, and the treatment dosage of biologically-active moiety is active constituent content, but the present invention is not limited thereto.

The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.Pass through Toxicity Determination earlier, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.On this basis, carry out field trial again.

Implementation of an application example one the implementation of Formulation Example

Embodiment 180% Propineb Fluoxastrobin wetting powder

Propineb 50%, Fluoxastrobin 30%, lignosulfonates 4%, polycarboxylate 3%, neopelex 4%, white carbon 9%, mixture carries out comminution by gas stream, makes 80% Propineb Fluoxastrobin wetting powder.

Embodiment 250% Propineb Fluoxastrobin wetting powder

Propineb 44%, Fluoxastrobin 6%, polycarboxylate 4%, DBSA 4%, white carbon 5%, kaolin 37%, mixture carries out comminution by gas stream, makes 50% Propineb Fluoxastrobin wetting powder.

Embodiment 325% Propineb Fluoxastrobin wetting powder

Propineb 20%, Fluoxastrobin 5%, alkyl benzene sulfonate calcium salt 4%, spaonin powder 5%, white carbon 8%, kaolin 58%, mixture carries out comminution by gas stream, makes 25% Propineb Fluoxastrobin wetting powder.

Embodiment 480% Propineb azoxystrobin water dispersible granule

Propineb 70%, Fluoxastrobin 10%, alkylphenol-polyethenoxy are phonetic 3.5%, polycarboxylate 3%, lauryl sodium sulfate 4.5%, starch 9%, mixed 80% Propineb azoxystrobin water dispersible granule.

Embodiment 570% Propineb azoxystrobin water dispersible granule

Propineb 57%, Fluoxastrobin 13%, polyoxyethylene carboxylate 4%, polycarboxylate 3%, lauryl sodium sulfate 5%, urea 2%, starch 16%, the mixed 70% Propineb azoxystrobin water dispersible granule that gets.

Embodiment 630% Propineb azoxystrobin water dispersible granule

Propineb 26%, Fluoxastrobin 4%, lignosulfonates 5%, spaonin powder 4%, ammonium sulfate 2%, starch 10%, kaolin 49%, the mixed 30% Propineb azoxystrobin water dispersible granule that gets.

Embodiment 740% Propineb Fluoxastrobin suspending agent

Propineb 35%, Fluoxastrobin 5%, lignosulfonates 4%, soapberry powder 4%, silicone oil 0.06%, polyvinyl alcohol 0.2%, deionized water add to 100%, the mixed 40% Propineb Fluoxastrobin suspending agent that gets.

Embodiment 830% Propineb Fluoxastrobin suspending agent

Propineb 27%, Fluoxastrobin 3%, alkyl benzene sulfonate calcium salt 4%, silkworm excrement 5%, silicone oil 0.08%, xanthan gum 0.3%, glycerine 2% deionized water add to 100%, the mixed 30% Propineb Fluoxastrobin suspending agent that gets.

Embodiment 915% Propineb Fluoxastrobin suspending agent

Propineb 13%, Fluoxastrobin 2%, polycarboxylate 5%, lauryl sodium sulfate 4%, silicone oil 0.08%, hydroxyethylcellulose 0.2%, ethylene glycol 2%, deionized water adds to 100%, the mixed 15% Propineb Fluoxastrobin suspending agent that gets.

Implementation of an application example two: Propineb and Fluoxastrobin are mixed to the sigatoka Toxicity Determination

This experimental establishment is in plant protection institute of Shandong Agricultural University, and after the effective inhibition concentration scope of each medicament was determined in prerun, each medicament was established 5 dosage respectively by active constituent content and handled, and established the clear water contrast.Carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", adopt the mycelial growth rate method to measure the virulence of medicament sigatoka.Measure colony diameter with the right-angled intersection method behind the 96h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.Result of the test is as shown in table 1:

Table 1 Propineb, Fluoxastrobin and use toxicity test analysis of results table with to sigatoka

As shown in Table 1, Propineb, Fluoxastrobin are to the EC of sigatoka₅₀Be respectively 11.74mg/L and 2.75mg/L.The virulence of Fluoxastrobin is higher than the virulence of Propineb.1: 1,4: 1,7: 1,10: 1,13: 1 synergy ratio of Propineb and Fluoxastrobin proportioning is respectively 1.07,1.84,2.13,1.98,1.48, and both proportionings are to show as certain synergistic effect at 4: 1,7: 1,10: 1 o'clock.

Embodiment uses three Propinebs and the Fluoxastrobin control alternaria leaf spot of apple test of pesticide effectiveness that is mixed

This experimental establishment is at Pucheng County, Shaanxi Province plant protection unit, and test medicine is researched and developed, provided by Shaanxi Pucheng County Meibang Pesticide Co., Ltd., contrast medicament 70% Wettable propineb powder (commercial), 25% Fluoxastrobin suspending agent (commercial).

The apple disease index is calculated in investigation before the medicine, and dispenser in per 7 days once is total to dispenser 3 times.Investigate disease indexs in 7 days, 30 days after the last dispenser and calculate preventive effect.Experimental result is as follows:

Table 2 Propineb, Fluoxastrobin and the control alternaria leaf spot of apple test of pesticide effectiveness that is mixed thereof

Handle medicament	Extension rate	7 days preventive effects (%) behind the last medicine	30 days preventive effects (%) behind the last medicine
				80% Propineb Fluoxastrobin wetting powder	4000 times	70.39	84.72
70% Propineb azoxystrobin water dispersible granule	3000 times	69.27	86.45
				30% Propineb Fluoxastrobin suspending agent	800 times	71.42	85.09
70% Wettable propineb powder	800 times	55.17	72.46
				25% Fluoxastrobin suspending agent	2000 times	60.84	72.00

As can be seen from Table 2, energy effectively preventing alternaria leaf spot of apple behind Propineb and the azoxystrobin compound, control efficiency is better than contrasting medicament, and the lasting period is long.In the test scope of medication, the target crop there is not harm.

Implementation of an application example four: Propineb and Fluoxastrobin are mixed and prevent and treat the early blight of tomato test of pesticide effectiveness

This experimental establishment is in Chen Zhuan town, Pucheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi Pucheng County Meibang Pesticide Co., Ltd., contrast medicament 70% Wettable propineb powder (commercial), 25% Fluoxastrobin suspending agent (commercial).

The early blight of tomato state of an illness is calculated in investigation before the medicine, and in dispenser for the first time on June 3, dispenser in per 7 days once is total to dispenser 2 times.Investigate disease indexs in 7 days, 14 days after the last dispenser and calculate preventive effect.Experimental result is as follows:

Table 3 Propineb, Fluoxastrobin and be mixed and prevent and treat the early blight of tomato test of pesticide effectiveness

Handle medicament	The preparation dosage	7 days preventive effects (%) behind the last medicine	20 days preventive effects (%) behind the last medicine
				50% Propineb Fluoxastrobin wetting powder	60 gram/mus	63.72	89.42
80% Propineb azoxystrobin water dispersible granule	40 gram/mus	68.45	88.74
				15% Propineb Fluoxastrobin suspending agent	150 gram/mus	60.32	90.08
70% Wettable propineb powder	120 gram/mus	57.04	81.37
				25% Fluoxastrobin suspending agent	30 gram/mus	62.27	85.12

As can be seen from Table 3, energy effectively preventing early blight of tomato behind Propineb and the azoxystrobin compound, control efficiency all is better than contrasting medicament, in the test scope of medication target crop is not had harm.

Implementation of an application example five: Propineb and Fluoxastrobin are mixed and prevent and treat the cucumber downy mildew test of pesticide effectiveness

Test medicine provides by Shaanxi Pucheng County Meibang Pesticide Co., Ltd., and the cucumber downy mildew state of an illness is calculated in investigation before the medicine, and dispenser in per 7 days once is total to dispenser 2 times.Respectively with second time medicine before, 7 days, 20 days investigation disease indexs and calculate preventive effect behind the medicine for the second time.Experimental result is as follows:

Table 4 Propineb, Fluoxastrobin and the control cucumber downy mildew test of pesticide effectiveness that is mixed thereof

Handle medicament	The preparation dosage	Preventive effect (%) before the secondary medicine	7 days preventive effects (%) behind the secondary medicine	20 days preventive effects (%) behind the secondary medicine
					25% Propineb Fluoxastrobin wetting powder	90 gram/mus	42.71	69.05	87.45
30% Propineb azoxystrobin water dispersible granule	80 gram/mus	40.72	71.32	89.34
					40% Propineb Fluoxastrobin suspending agent	70 gram/mus	39.55	71.55	86.50
70% Wettable propineb powder	140 gram/mus	23.09	60.41	65.44
					25% Fluoxastrobin suspending agent	40 gram/mus	40.58	68.75	78.39

As can be seen from Table 4, energy effectively preventing cucumber downy mildew behind Propineb and the azoxystrobin compound, control efficiency all is better than contrasting medicament, in the test scope of medication target crop is not had harm.

Claims (4)

1, a kind of bactericidal composition that contains Propineb and Fluoxastrobin is characterized in that the effective active composition contains Propineb and Fluoxastrobin, and wherein the percentage by weight of Propineb and Fluoxastrobin is 5～80: 40～1.

2, the bactericidal composition that contains Propineb and Fluoxastrobin according to claim 1 is characterized in that the percentage by weight after Propineb and Fluoxastrobin are preferably is 10～70: 30～5.

3, the bactericidal composition that contains Propineb and Fluoxastrobin according to claim 1 is characterized in that: the effective active composition adds conventional auxiliary agent and excipient and makes wetting powder, water dispersible granules, suspending agent.

4, the bactericidal composition that contains Propineb and Fluoxastrobin according to claim 1 is used to prevent and treat early blight of tomato, cucumber downy mildew, alternaria leaf spot of apple, sigatoka.