CN101498655B - Detecting instrument for liquid sample - Google Patents

Abstract

The invention provides a liquid sample detecting device comprising a first cavity, a second cavity, a detecting element and a third cavity. The first cavity is provided with an opening for guiding a liquid sample in the first cavity; the second cavity is connected with the third cavity through a through hole; the detecting element is accommodated in the second cavity; the third cavity is connected with the second cavity through a channel, and the third cavity is internally provided with a movable element which is provided with a first position and a second position and divides the third cavity into a first area and a second area, wherein the first area is provided with an air outlet; and the movable element is in air-tight sealing fit with the wall surface of the third cavity so as to avoid the mutual flowing of air in the first area and the second area. The liquid sample detecting device starts and stops detecting with the liquid surface tension and the air pressure difference, is very easy to operate and reduces the harm of the liquid sample to the operator.

Description

The pick-up unit that is used for liquid sample

The application is dividing an application of No. the 200510113977.5th, one Chinese patent application

Technical field

The present invention relates to a kind of pick-up unit whether the tracer liquid sample exists analyte that is used for.

Background technology

At medical health field, detecting body fluid is a general behavior.Factory, government organs, team and other are organized and are increasingly utilized diagnostic test to come the safety in maintenance work place and guarantee to abide by law, rules and article.

Utilize pick-up unit to collect liquid sample,, and judge whether to exist specific analyte (like drugs and/or its metabolin, or with the mark of disease association) to become a kind of very general method like urine.The device of test generally requires sample to be collected in the sampling receptacle like this, and person skilled is inserted a test strip and the part of test strips is submerged in the sample, takes out test strips subsequently and reads the result.The technician may touch sample, and may jeopardize health or make sample contaminated.For avoiding this risk, need on collection containers, add the laggard line operate of closure body.At present, had many obturators, like U.S. Pat 4,976,923, US 5,429, and 804 and the device that disclosed of US 6,726,879.These devices are that test strip is fixed on the lid of pick-up unit.During use, sample infiltration test strip is detected container upset or inclination.U.S. Patent No. application on the 6th February in 2003 US2003/0027359A1 has disclosed a kind of detection urine cup.This detection urine cup still needs to promote the pillar piston motion and fluid sample is flowed out and moistening detecting element from the cup cavity with push rod cover the opening of cup at lid after.

Recently, this pick-up unit is adopted by average family or amateur mechanism more and more.Because these detect assessment is to aim at the layman to design, so these pick-up units need make operating process simple, and can guarantee the accuracy of testing result.

Therefore, simple to operate and testing result accurately and reliably pick-up unit be the required of society at present.The present invention just provides a kind of pick-up unit that meets this demand.

Summary of the invention

Pick-up unit comprises the opening of liquid sample being introduced first cavity, second cavity, and second cavity is communicated with the through hole of first cavity through first cavity bottom, and wherein detecting element is housed in second cavity.Pick-up unit also comprises the 3rd cavity; The 3rd cavity is connected with the passage of second cavity through the 3rd cavity wall, and the 3rd cavity contains movable element, and movable element has the primary importance and the second place; Movable element is divided into first district and second district with the 3rd cavity; There is an exhaust outlet in first district, and movable element cooperates with the wall hermetic seal of the 3rd cavity, circulates each other to avoid the gas in first district and second district.

Pick-up unit also can comprise the lid that covers on said opening, and testing element is a test card, and it includes one or more and detects test paper.

The movable element of this pick-up unit can be a piston, and piston has a seal.Piston is positioned in the 3rd cavity, and the sealing part cooperates with the wall hermetic seal of the 3rd cavity, to prevent first district and the circulation of air in second district in the 3rd cavity.The 3rd cavity also comprises a bottom, and in the present invention, exhausr port is located at this bottom.In a certain embodiment, piston has the push rod that extends to the collection container opening.Said lid has a press surface; When the cover cap upper shed; Press surface compresses push rod and promotes piston motion towards the bottom of the 3rd cavity, and discharges the air of part at least in first district of the 3rd cavity, and the air pressure in second district of second cavity and the 3rd cavity is reduced; Thereby the liquid in first cavity is drawn into the sample region of acceptance of second cavity and moistening test strip, thereby detects automatically.

The through hole of first cavity bottom of pick-up unit can have different diameters, less than 10 millimeters or less than 9 millimeters or less than 8 millimeters or less than 7 millimeters or less than 6 millimeters or less than 5 millimeters or less than 4 millimeters, or less than 3 millimeters.

On the other hand, the present invention also provides the detection method that whether has analyte in the tracer liquid sample.This method comprises introduces pick-up unit with the tracer liquid sample; Promote movable element and move to the second place from primary importance; And make the part air of second cavity be inhaled into the 3rd cavity, thereby moistening detecting element detects after making the liquid of certain volume get into second cavity through through hole from first cavity.Through observing the variation of detecting element, judge whether there is analyte in the liquid sample then.

In a certain embodiment; This method comprises that when the cover cap upper shed, lid contacts and promote push rod with push rod, thereby causes that movable element moves to the second place from primary importance; Thereby cause that the 3rd cavity produces negative pressure, makes the portion gas of second cavity be inhaled into the 3rd cavity.Gas gets into the 3rd cavity from second cavity and causes second cavity to produce negative pressure, and for reaching pressure equilibrium, the liquid in first cavity just " is drawn onto " in second cavity, and moistening detecting element, detects.On the other hand, beyond the exhausr port delivery detection device of the air in the 3rd cavity through its bottom, thereby can not hinder piston in the 3rd cavity, to move to the second place by primary importance.

Not only for fixing in the above-mentioned explanation, other features and advantages of the present invention will embody from following detailed description and claim to general introduction of the present invention.

Description of drawings

Fig. 1 is the three-dimensional exploded view of pick-up unit of the present invention.

Fig. 2 is the three-dimensional exploded view at another visual angle of pick-up unit of the present invention.

Fig. 3 is the stereographic map after pick-up unit of the present invention removes lid.

Fig. 4 pick-up unit of the present invention removes the inverted perspective view behind the base.

Fig. 5 is a pick-up unit cross-sectional view strength of the present invention, in the liquid sample existence as shown in the figure and first and second cavitys.

Fig. 6 is Fig. 5 partial enlarged drawing, for the structure that clearly demonstrates through hole is not presented at liquid sample among this figure.

Fig. 7 is a cross-sectional view strength of the present invention, is presented at the push rod of primary importance and exists only in the liquid sample in first cavity.

Fig. 8 is Fig. 7 partial enlarged drawing, for the structure that clearly demonstrates passage is not presented at liquid sample among this figure.

Fig. 9 is the cross-sectional view strength that is similar to Fig. 7, show that push rod is in the second place, and a part of liquid sample flows into second cavity.

Embodiment

The invention provides the apparatus and method of analyte in a kind of tracer liquid sample.In one embodiment, this pick-up unit has a cup to be used to collect liquid sample.This liquid sample can be a urine sample.Analyte can be glucose, drugs or its metabolic product.

This device utilizes cavity system transfer liquid sample, and the situation of analyte in the test sample.In one embodiment, pick-up unit has three cavitys, utilizes draught head can liquid sample be transferred to another cavity from a cavity.About equally the time, surface tension of liquid can remain on liquid sample in the cavity at each cavity air pressure.When only between cavity, having draught head, sample just can be transferred in the cavity at the bottom of the air pressure from the high cavity of air pressure.The mode (like the vacuum form) that draught head can adopt air pressure inside to increase or reduce.Different cavitys is through through hole, and passage is connected with exhausr port, and these devices make gas transmit in different chambeies with liquid sample.This pick-up unit also contains movable element to be deposited in the cavity.In one embodiment, movable element is a piston, and cavity is the cylindrical piston that is used to deposit.When push rod moves to the second place from primary importance, air is discharged in the 3rd cavity by piston, makes the 3rd cavity form negative pressure.Because of the 3rd cavity communicates with second cavity, thereby second cavity also can form negative pressure.This negative pressure has been destroyed the surface tension of liquid of first cavity, makes liquid sample flow into second cavity from first cavity via the through hole of its bottom, thus moistening detecting element and detecting.Cylindrical structural is meant and can holds movable element that movable element can move to the second place from primary importance within it.The 3rd cavity also needs not be the cylindrical of standard very, can be different shape and size, is a kind of shape at a certain position perhaps, is other shapes at another position, as long as in analytic process, can realize its function.

In one embodiment, the testing element and second cavity are used, and sample is analyzed.As shown in the figure, movable element has the piston structure of cylindrical shape.But movable element also can adopt other suitable shapes.

Analyte

Detecting element among the present invention can be analyzed various types of analytes.Analyte can be that the material that is infectious maybe can be indicated the material of infection period.Analyte can be medicine (like a drug abuse), hormone, albumen, nucleic acid molecules, pathogen." drug abuse " (DOA) is meant that the non-medical destination uses medicine (playing the paralysis nerve usually).Abuse these medicines and can cause body & mind to suffer damage, produce dependence, habit-forming and/or dead.The example of drug abuse comprises cocaine; Amphetamine (for example, black beauty, white amphetamine tablet, dextroamphetamine, dexie, Beans); Crystal methamphetamine (crank, meth, crystal, speed); Barbiturate is (like RochePharmaceuticals; Nutley, New Jersey); Sedative (paramedicines of promptly sleeping); Lysergic acid diethylamide (LSD); Suppressant (downers, goofballs, barbs, blue devils, yellow jackets, methaqualone); The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin); Hog (PCP); Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); Opiate (being morphine, opium, codeine, heroin, the hydroxyl dihydrocodeinone).Use this test strip also can be used to belong to medical usage but the detection of overdose easily, like tricyclic antidepressant (imipramine or analog) and Paracetamol.

Detecting element

Testing element can be selected the test strip of cross flow for use, and it can detect multiple analyte.Certainly, other suitable detecting elements also can be used in the present invention.Various detecting elements can be combined in together and apply among the present invention.A kind of form is to detect test paper.The detection test paper that is used for the analyte (like drugs or show the metabolin of health) of analytic sample can be a various forms, like immunoassays or chemico-analytic form.Detect the analytical model that test paper can adopt non-competing method or competition law.Detect test paper comprise one have a sample pipetting volume district absorbent material, reagent area and test section.Add sample to the sample pipetting volume district, flow to reagent area through capillarity.At reagent area, if there is analyte, sample combines with reagent.Sample continues to flow to detection zone then.Other reagent are fixed on detection zone like the molecule that combines with analyte specially property.Analyte in these reagent and the sample (if existence) reacts and analyte is combined in this district, perhaps combines with the some reagent of reagent area.The label existence that is used to show detection signal and reagent area or the mark zone that separates.

Typical non-competing method analytical model is that signal will produce if contain analyte in the sample, if do not comprise analyte, does not just produce signal.In competition law, if analyte is not present in the sample, signal produces, if there is analyte, does not then produce signal.

Testing element is to detect test paper, the material that can select suction for use or not absorb water.Detect test paper and can comprise that multiple material is used for the liquid sample transmission.Wherein a kind of material that detects test paper can cover on the another kind of material, covers on the nitrocellulose filter like filter paper.A district detecting test paper can select one or more materials for use, and another district selects other one or more different materials for use.The detection test paper can be attached on certain holder or hard surface is used to improve the intensity of being affectedly bashful the detection test paper.

Analyte is detected through signal generating system; Like utilization one or more enzymes with this analysis thing generation specific reaction; Utilize as aforementioned specific combinating substance is fixed on the method that detects on the test paper, the composition of one or more signal generating systems is fixed on the analyte detection zone of detection test paper.The material that produces signal can be in sample application zone, reagent area, or detection zone, or on the whole detection test paper, this material can be full of on one or more materials that detect test paper.The solution that will contain the signal thing is added to the surface of test paper or one or more materials of test paper is immersed in the solution that contains the signal thing.Make and add the test paper drying that contains signal thing solution.

Each district of detecting test paper can arrange by following mode: sample application zone, and reagent area, detection zone, the control zone confirms whether sample mingles the district, the liquid sample uptake zone.The control zone is positioned at after the detection zone.All districts only can be arranged on the test paper with a kind of material.Also but material different is not adopted in the same district.Each district can directly contact with liquid sample, or different districts arranges according to the direction that liquid sample flows, and the end in Jiang Ge district links to each other with the front end in another district and overlaps.Used material can be water absorptivity material such as a filter paper preferably, glass or nitrocellulose filter etc.Detect test paper and also can adopt other forms.

Pick-up unit

With reference to Fig. 1 and 2, pick-up unit of the present invention is used to collect body fluid like urine, and analyzes the situation of its contained analyte (like drugs and metabolin thereof).This pick-up unit comprises that one has thecontainer body 111 that opening 115 is used to collect liquid sample, thelid 101 of sealing opening, the detectingelement 137 that is used to detect.In one embodiment,lid 101 is closed through rotation mode, also can be through pushing or other modes realize.Pick-up unit contains aseal element 109, makes afterlid 101 covers to seal.Contain a movable element at this container, like piston, piston is removable in cavity.

Pick-up unit can be processed by multiple different shape and material different.For example, plastics of all size etc.With reference to accompanying drawing, pick-up unit comprises themain body 111 and apedestal 151 of a cup, andpedestal 151 is airtight is bonded inmain body 111 bottoms.With reference to accompanying drawing 3,5,7 and 9,main body 111 contains a plurality of vertical sidewalls that are connected with each other 117, the circularupper edge 113 that links to each other with the vertical sidewall top.In one embodiment, it is parallel with two adjacent vertical walls to contain twoinwalls 309, and is connected on the top with vertical wall, forms second cavity 601.Thiscavity 601 contains detecting element.Coboundary 113 has anopening 115 to be used to receive liquid sample, and has screw thread to coincide with the screw thread oflid 101.

Pick-up unit comprises a movable element, when it when primary importance moves to the second place, can in certain chamber of pick-up unit, form negative pressure state.Shown in accompanying drawing, movable element is a piston.Themain body 111inner piston chamber 311 that form can carry out gas communication between the piston chamber and the second cavity top 211.Pistonchamber 311 forms the 3rd cavity.In the present embodiment, the shape of piston chamber's 311 parts is inverted infundibulates, comprises adrum shape bottom 303, and it communicates with the external world through the exhausr port on thediapire 207 of body 111.Piston chamber also comprises the cylindricalupper section 307 of diameter less thanbottom 303, connects the pars intermedia 305 on bottom and top.Shown in Fig. 7 and 8,piston chamber bottom 303 parts link to each other withinwall 309 parts, andpassage 801 can be that air is circulated between the3rd cavity 701 andsecond cavity 601." gas communication " means that the air pressure when certain cavity changes the air pressure that causes another cavity also changed that perhaps liquid sample is drawn onto in another cavity from a cavity, and perhaps gas can circulate between two cavitys.

Cavity

The cavity of pick-up unit can adopt Any shape.In the present embodiment, the 3rd cavity can adopt cylindrical, syringe-like shape, chimney, but perhaps other support activities elements any form of between the primary importance of the 3rd cavity and the second place, moving.The different parts of the 3rd cavity can take different shapes.Similarly, second cavity can adopt any form that can support detecting element, and first cavity can adopt any form that can collect liquid sample.

Main body diapire 207 (it forms the diapire of first cavity) comprises a throughhole 205, and this throughhole 205 connects first cavity and second cavity.The diameter of throughhole 205 is enough little to make that when air pressure balance, the liquid sample in themain body 111 can not flow.When movable element moves, produce air pressure official post liquid sample and flow to second cavity from first cavity.The diameter of through hole is less than 10 millimeters, or less than 9 millimeters, or less than 8 millimeters, or less than 7 millimeters, or less than 6 millimeters, or less than 5 millimeters, or less than 4 millimeters, or less than 3 millimeters or littler.In the present embodiment, about 4 millimeters of the diameter of throughhole 205, or about 5 millimeters, or between about 3 millimeters or the 3-5 millimeter.Throughhole 205 is mouths between first cavity and second cavity, and this throughhole 205 can have other versions.For example, through hole is combined into the combination groove by different minor diameters.Diapire 207 also is provided withrelief 209, and thisrelief 209 is located at around the open area on the diapire.

Pedestal 151 nonvolatil being bonded on the main body 111.Pedestal 151 comprises aupper wall 153, anddiapire 213 is being connected upper wall and diapire with enclosure wall 155.Form agroove 157 betweendiapire 213 and theenclosure wall 155, this groove is the part of second cavity, is used for the acceptable solution sample body.There is the crank slot can be chimeric with the relief onmain body 111diapires 207 at the top of enclosure wall 155.Whenpedestal 151 is placed in 111 last times of main body,relief 209 is embeddedcrank slots 159, use ultrasonic soldering then.Any method of fine sealing between pedestal and the main body that makes all can be used.Like sweat soldering, glue connection etc.Pedestal 151 also comprises theholding board 161 that is used to deposit detecting element, and the flow-stoppingplate 163 of slowing down fluid speed is positioned at theexhausr port 165 on theupper wall 153.

Lid 101 can covercollection container 313 with the liquid sample in the airtight container.In the present invention, combining of lid and collection container can detection starting, hereinafter can dodetailed description.Lid 101 comprises the top, and by thewheel rim 105 that the top periphery extends to form downwards, screw thread in thewheel rim 105 and the screw thread on thecircular edge 113 on thecollection container 313 coincide.In the present embodiment, a circularconcave surface 107 is arranged attop 103, and this concave surface is pushedbottom surface 201 and is used for whenlid 101 coverscollection container 313, pushing movable element 215.Sealing ring 109 encircles betweenlid 101 andcollection container 313 further to guarantee sealing between the two like O shape.

Testing element is the card shape, can cooperate with the pick-up unit of Any shape to carry out check and analysis.In the present embodiment, detecting element comprise thetest sample card 119 that is used for detecting the sample analyte be used to detect sample whether contaminated or do not mingled mingle test card 131.Each test card 119 (131) has certain size and shape can be inserted in the top 211 of second cavity 601.And it is fixing by theholding board 161 of pedestal 151.Test card can be fixed insecond cavity 601 in any suitable manner.Each test card 119 (131) includes the panel 121 (133) of some accepting grooves 123 (135), plurality ofdetection test strips 125 ormingle bar 137 and be fixed in the accepting groove.The thin slice 127 (139) that is used to hide test strip and mingle bar is attached on the surface of test sample card, and thin slice is provided with view window 129 (141) and is used to observe testing result.

Movable element 215 can move in piston chamber 311.Movable element is apiston 215 in the present embodiment.Piston comprise one throughpiston chamber 311top 307 and extend to alengthwise push rod 147 of the opening 115 of collection container 313.Pistonbody 149 links to each other withpush rod 147 bottoms, and has certain size and dimension and can in thebottom 303 ofpiston chamber 311, move.First O-ring seal 143 be fixed onpush rod 147 around, second O-ring seal 145 be fixed onpiston body 149 around.Shown in accompanying drawing, the cross sectional dimensions of first O-ring seal 143 andpush rod 147 is significantly less than the cross sectional dimensions of second O-ring seal 145 and piston body 149.O-ring seal 143 and 145 can be rubber ring or the plastic hoop that goes in ring.O-ring seal can become any form with any suitable material, as long as it meets the requirement of sealing.

With reference to accompanying drawing 5-9,pedestal 151 is formedcomplete collection container 313 by permanentmain body 111 bottoms that are installed to.Under the state after the installation,main body 111 innerfirst cavitys 301 through opening 115 collections and storaging liquid sample that form.Second cavity 601 comprises that thegroove 157 that formed bypedestal 151 andtop 211 is used to deposit detecting element.Throughhole 205 can make liquid sample flow tosecond cavity 601 from first cavity 301.This through hole tool has the dimensions and can form surface tension of liquid and prevent that liquid sample from flowing to second cavity from first cavity, up to owing to push push rod in the 3rd cavity and make second cavity produce vacuum state " to drag " or attract liquid sample to get into second cavity.As previously mentioned, throughhole 205 can be a undersized hole.

Shown in Fig. 7-9, the inwall of the3rd cavity 701 forms a piston chamber 311.Whenpiston 215 was housed in thepiston chamber 311, its first O-ring seal 143 and second O-ring seal 145 played sealing function at the3rd cavity 701 respectively.First district 901 is the zones between second O-ring seal 145 and diapire, and second district 902 is the zones between first O-ring seal 143 and second O-ring seal 145.Whenpiston 215 moved in the3rd chamber 701, first and second O-ring seals 143,145 closely contacted with thetop 303 ofpiston chamber 311 and the inwall ofbottom 307 respectively, circulated each other to prevent the gas in first district 901 and second district 902.Because the cross sectional dimensions of first O-ring seal 143 andpush rod 147 is significantly less than the cross sectional dimensions of second O-ring seal 145 andpiston body 149, so, when movable element when primary importance moves to the second place, the volume in first district and second district changes.When movable element was in the bottom in the 3rd chamber,passage 801 kept the gas communication of second cavity and the 3rd cavity.Passage 801 can adopt various suitable structures, but must between second chamber and the 3rd chamber, an opening be arranged, and guarantees the air flow between two chambeies.Shown in accompanying drawing, the3rd cavity 701 is positioned in the inside ofcollection container 313, and more particularly, the3rd cavity 701 is positioned in the inside offirst cavity 301.

Method of application

When detecting, at first liquid sample is joined in first cavity of collection container through opening.Liquid sample is stored in first cavity.Since exist surface tension of liquid and each chamber in air pressure about equally, make liquid sample can not pass through throughhole 205, get into second chamber up to second cavity, 601 internal gas pressures minimizing attraction liquid sample.

Lid 101 covers on thecollection container 313, as utilizing the mode that screws in.With reference to shown in Figure 7, when beginning to detect,piston 215 is positioned at primary importance.When primary importance,push rod 147 extends the bigger distance of first cavity, and along with lid screws in, thepress surface 107 that is positioned at lid touches the push rod top.Pistonbody 149 ends at 303 places, bottom of piston chamber 311.In one embodiment,piston body 149 is inconsistent with the some fins that protruded out by pars intermedia 305.When piston was positioned at first district, the volume in second district was positioned at the i.e. volume the during bottom of the second place less than piston relatively in the3rd cavity 701.

Whenlid 101 screwed in collection container, thebottom 201 ofpress surface 107 contacted withpush rod 147, impels piston to move to the second place along its y direction by primary importance.Along with piston moves to the second place from primary importance, the air in first district is discharged from exhausr port.Simultaneously, second district forms negative pressure, forces portion gas insecond cavity 601 to be inhaled into second district of the 3rd cavity.This process causes that second cavity, 601 gas loss produce negative pressure, and this negative pressure is then further destroyed the surface tension of liquid of throughhole 205, thereby the liquid sample in " dragging " first cavity gets intosecond cavity 601 through through hole 205.The liquid sample that gets into second cavity contacts with the detecting element that is positioned at second cavity.Exhausr port can adopt any structure form that meets degassing function.

As illustrated in Figures 5 and 6, flow-stopping plate 163 is located immediately at liquid sample and flows on the inflow route of second cavity from first cavity.Flow-stopping plate plays the effect that stop portions gets into the liquid sample ofsecond cavity 601, prevents that too fast liquid sample flow velocity from causing damage or the generation flood phenomenon to detecting test paper 125,137.Flow-stopping plate 163 makes liquid sample before touching the detection test paper, change the direction that flows, and makes the liquid sample flow velocity reduce, slowly with 125,137 contacts of detection test paper.Liquid sample gets into detection zone through capillary action, through view window 129,141 observationss.Thesidewall 117 ofcollection container 313 can be transparent or translucent, so that operator's observations.

As shown in Figure 9, whenpiston body 149 when primary importance moves to the second place, the amount that gets into the liquid sample ofsecond cavity 601 enough can be soaked into and detected test paper but can be inexcessive and cause the mighty torrent phenomenon.Specific sample size is relevant with the setting of piston and the stroke of piston between the primary importance and the second place, and it can preestablish in process of production.In addition, the primary importance of piston can preestablish when producing, and its second place can be controlled by the user.When for example, on collectioncontainer screw thread 113, be beforehand with mark, rotate to the piston arrives second place to show when lid.In the present invention, covered in 313 last times of collection container the piston arrives second place fully when lid 10.Therefore, the operator only needs simple rotation lid to cover on the collection container, just can realize the purpose that detects.

The present invention can lack any element or limiting factor (s) is operated, and no longer explains at this.Term described in the utility model and expression way are not limited only to that instructions discloses.And the structure that we have no intention to use these terms and expression way to get rid of to describe the utility model or the expression way of characteristic same meaning, we admit the various expression way in the scope that the utility model is stated.Therefore, we think that the expression way of the design that discloses among this paper also will seek help from those experienced professional and technical personnel, and these changes are consistent with the subsidiary statement of the utility model.

Useful digitized information that mention among the content of article, patent, patented claim and all other documents and this paper and that quote as proof combines; Must come reference as a complete content, delivering wherein, any one part all will specialize this point.The applicant has the information of any and whole these articles, patent, patented claim or other document and material is integrated with a part of right that this application book discloses as patent specification.

Claims (11)

1. pick-up unit that is used for tracer liquid sample analyte is characterized in that comprising: first cavity, second cavity, the 3rd cavity and liquid sample introduced the opening of first cavity; Contain testing element in second cavity, second cavity is connected with first cavity through through hole; The 3rd cavity is connected through passage with second cavity; Wherein, when each cavity gas was pressed about equally, the surface tension of liquid of through hole stoped the liquid sample in first cavity to get into second cavity through this through hole; When having draught head between each cavity; Liquid sample is transferred to the low cavity of air pressure from the high cavity of air pressure, and wherein, draught head adopts inside cavity air pressure to increase or the mode of minimizing realizes; Wherein, The 3rd cavity contains movable element, and movable element has the primary importance and the second place, and movable element is divided into first district and second district with the 3rd cavity; There is an exhausr port in first district, and movable element cooperates the gas to avoid first district and second district to circulate each other with the wall hermetic seal of the 3rd cavity.

2. pick-up unit as claimed in claim 1 is characterized in that: the diameter of through hole that connects first cavity and second cavity is less than 10 millimeters.

3. pick-up unit as claimed in claim 1 is characterized in that: the diameter of through hole that connects first cavity and second cavity is less than 5 millimeters.

4. pick-up unit as claimed in claim 1 is characterized in that: the diameter of through hole that connects first cavity and second cavity is less than 4 millimeters.

5. pick-up unit as claimed in claim 1 is characterized in that: the diameter that connects the through hole of first cavity and second cavity is less than 3 millimeters.

6. pick-up unit as claimed in claim 1 is characterized in that: said through hole is combined into the combination groove by the hole of a plurality of different minor diameters.

7. like any one described pick-up unit of claim 1-6, it is characterized in that: the activity of described movable element in the 3rd cavity causes between first cavity, second cavity and produces draught head.

8. pick-up unit as claimed in claim 7 is characterized in that: the 3rd cavity also comprises a bottom, and this exhausr port is set at this bottom and leads to outside the pick-up unit.

9. pick-up unit as claimed in claim 8; It is characterized in that: said movable element is a piston; This piston comprises the piston push rod and the piston body that extend to said opening; First O-ring seal be fixed on piston push rod around, second O-ring seal be fixed on piston body around, the cross-sectional area of first O-ring seal is less than the second O-ring seal cross-sectional area.

10. pick-up unit as claimed in claim 7 is characterized in that: the 3rd cavity is positioned in the inside of first cavity.

11. any one the described pick-up unit like claim 1-6 is characterized in that: be provided with flow-stopping plate at liquid sample from the inflow route that first cavity flows into second cavity, so that before liquid sample contacts described testing element, slow down the liquid sample flow velocity.

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