Background technology
The artificial growth body technique has been a mature technique, and is widely applied to the many aspects such as reparation, jaw defect, eyeball, auricle, external nose defect repair body maintenance of agomphosis.In 10 years of past, oral implantology also moves to maturity gradually, has had the rationale of system; The design and manufacturing technology of system of implantation body is gradually improved; A series of tooth-planting surgical technics, implant denture recovery technique, skilled worker chamber process technology be standard; Formed a tooth-planting professional contingent huge, the process special training in countries in the world; The patient of dentition defect, defect of dentition who accepts oral implant rehabilitation is more and more; Nascent various dispute is fewer and feweri.Wherein, canine implant is that the canine implant root is implanted in the alveolar bone, after the artificial growth root of the tooth of implanting and alveolar bone reach good synosteosis, finish corresponding artificial tooth reparation thereon, thereby reach the recovery patient and lack tooth, recover patient's interlock masticatory function, recover patient's face type and therapeutic modality attractive in appearance.
At present, clinical common implantation body is endosteal implant, and majority is pure titanium manufacturing, and the surface is carried out different PROCESS FOR TREATMENT and improved combining of implantation body and bone.Be broadly divided into cylindric and root shape implantation body etc. according to the form of implantation body.The surface can be threaded or not threaded.Inside is solid construction, and top band hollow key way links to each other with fixed screw.Existing implantation body only is used for bearing a heavy burden and maintenance, can not be used for administration.
Summary of the invention
Technical problem to be solved by this invention provides a kind of artificial implant general medicine feeder that has mesh, this device both can be used for administration, also can be used as implantation body, this device comprises implantation body, medicine storing bag and capping screw, medicine in the medicine storing bag can absorb by the osseous tissue of bone regeneration around implant, make drug absorption be diffused into part or whole body, the series of studies by this implantation body can provide a kind of new route of administration for clinical.
Technical scheme provided by the invention is: a kind of artificial implant general medicine feeder that has mesh, comprise implantation body, medicine storing bag and capping screw, and implantation body is a hollow structure, and implantation body is provided with the drug flow through hole, and medicine storing bag is located in the implantation body.
Further, described drug flow through hole is a plurality of, is evenly distributed in the implantation body.
Further, described implantation body comprises implant and the base station that is located at superplant, and implant closely is connected with base station, and described medicine storing bag is located at plants in the body, and is closed in the implantation body by the capping screw.
Further, described base station bottom is a hexahedron, superplant is provided with the hexagon locating slot that links to each other with the base station buckle, is provided with the female thread that is connected with the capping screw thread in described superplant and the base station, and capping screw upper end is provided with " one " font groove of fastening and afterburning usefulness.
Further, the diameter of described implant is 5-6mm, and length is 10-16mm, implant thickness of pipe wall 1.5mm.
Further, described medicine storing bag is a network structure.
Further, described implant is a network structure, and the drug flow through hole is a mesh.
Further, 2/3 part of described implant is a network structure, and the drug flow through hole is a mesh.
Further, described medicine storing bag and medicament slow release controlled release system are made of one structure.
Further, described implantation body is the manual tooth planting's body that has mesh.
Drug sustained release system has overcome the drawback of frequent drug administration, helps reducing the untoward reaction of medicine, can keep drug disposition valid density in a long time, thereby can improve the compliance that the patient takes medicine greatly, is widely used in treating multiple disease.Now the drug sustained release system that uses comprises: 1. drug administration by injection: can a few days or the several months injection once, can significantly reduce the medication number of times, strengthen the safety of medicine, improve patient's compliance.Comprise solid lipid nanoparticle, nanosphere (capsule), nanoparticle active carbon, Emulsion, long circulation immunity liposome, injection gel, needleless medicine-releasing system, slow releasing capsule, the subcutaneous medicine-releasing system of accurate miniature pump etc.; 2. oral administration: comprise microcapsule (ball), oral sustained release bioadhesive tablet, Oros sheet, gastric retention type floating slow-release tablet, solid fat nanoparticle, segmented intestine targeted site-specific delivery of drugs system etc.; 3. oral cavity local medication: comprise wafer, double-deck mouth paster, Sublingual bioadhesive tablet etc.; 4. embedded type administration: comprise membrane, cast drug-supplying system, matrix type drug-supplying system etc.; 5. dosing eyes; 6. nasal cavity powder formulation and microball preparation administration; 7. pulmonary's navigation system administration: comprise liposome and Foradil Aerolizer formoterol fumarate etc.; 8. external preparation and transdermal administration: comprise miniature sponge and microneedle cutaneous etc.All these slow-released systems all to the location, regularly, the directed medicine that discharges brought into play certain effect.
According to the characteristic of artificial growth body and the principle of said medicine slow-released system, the inventor and then finished the present invention.
The present invention has following advantage: (1) both can be used for administration, as the prevention and the curative antibiotic topical that can be applied to infectious disease, the local sustained release administration of the long-term systemic administration of chronic disease, the slow release topical of the immunosuppressant after the organ transplantation, the auxiliary targeted local administration of tumor disease etc., also can be used as general implantation body, be used to repair the affected part.Be convenient to when (2) using change, be easy to regulate.(3) can the oneself control.(4) temperature is comparatively constant in the body, helps the pharmaceutical dosage form preparation.(5) the open internal and external environment of can withing a hook at the end can give different medicines according to different diseases.(6) simple in structure, practical, easy to utilize.
The specific embodiment
Explain the present invention in more detail below in conjunction with embodiment preferred.
See also Fig. 1 and Fig. 2, the present invention has the artificial implant general medicine feeder of mesh, is made up of implantation body,medicine storing bag 3 andcapping screw 4, and wherein, implantation body is made up ofbase station 2 andimplant 1, and in the present embodiment, implantation body is artificial toothimplant.Base station 2 bottoms are hexahedron, andimplant 1 top is provided with thehexagon locating slot 6 that links to each other withbase station 2 buckles, andbase station 2 links to each other withimplant 1 buckle.The bottom sealing ofimplant 1, the remainder ofimplant 1 is a hollow structure,implant 1 is provided with several equally distributed drug flow throughholes 5, in the present embodiment, 2/3 part of implant is a network structure, and drug flow throughhole 5 is a mesh, so that medicine enters in the body.The shape ofimplant 1 can be designed to column or taper, the diameter ofimplant 1 and length also can design as required,diameter 1 is intensity and the necessary drug storage space to guarantee that implantation body is enough too carefully, the diameter ofimplant 1 is 5-6mm, length is 10-16mm, and is preferable during the about 1.5mm ofimplant 1 thickness of pipe wall.Medicinestoring bag 3 is a network structure, is located in theimplant 1, is provided with the female thread that is threaded withcapping screw 4 in themedicine storing bag 3, and cappingscrew 4 upper ends are provided with " one "font groove 7 of fastening and afterburning usefulness, andmedicine storing bag 3 is closed in the implantation body by capping screw 4.Medicine storing bag 3 can be made of one structure with the medicament slow release controlled release system, also can not be made of one with the medicament slow release controlled release system.
Using method of the present invention is as follows: when the patient has anodontia to be fit to plantation, this device is designed to the form of canine implant, implant in the alveolar bone of oral cavity, cappingscrew 4 by Dental Implant is enclosed inmedicine storing bag 3 in the implantation body, medicine absorbs by the osseous tissue of bone regeneration around implant, make drug absorption be diffused into part or whole body, thus the performance therapeutical effect.Drug sustained release system in themedicine storing bag 3 can be changed at any time, and whenmedicine storing bag 3 and drug sustained release system were made of one,medicine storing bag 3 also can be changed at any time, very convenient administration.As the case may be, the present invention also can be designed to the artificial growth body of other form, is implanted to other position except that the alveolar bone of oral cavity.The present invention provides a kind of new route of administration for clinical, and simple in structure, is easy to apply.