CN101010115A - Electronically controlled pill and system for delivering at least one medicament - Google Patents

Abstract

An electronically controlled pill (100) or medicament delivery system is provided. The pill (100) includes a housing (102); a medicament reservoir (104) for storing a medicament; an electronically controlled release valve or hatch (106) for dispensing one or more medicaments stored in the medicament reservoir (104) while traversing the gastrointestinal tract; control and timing circuitry (108) for opening and closing the valve (106); and a battery (109). The control and timing circuitry (108) opens and closes the valve (106) throughout a dispensing time period in accordance with a preset dispensing timing pattern which is programmed within the control and timing circuitry (108).

Description

Be used to carry the electronically controlled pill and the system of at least a medicine

The present invention relates generally to delivery system.Especially, it relates to electronically controlled pill and the system that is used to carry at least a medicine.

Medicine carries out administration with pill or liquid usually, and take at least once every day.A people may need take or give several drugs at identical or different time durations every day.This needs hold the record daily record or remember to carry out taking of which kind of medicine or administration at different time in a day of this people or his caregiver.

By the medicine that this people takes, as aspirin, usually by gastrointestinal (GI) road, it is absorbed for treatment imbalance or disease at this.Object typically passed through the GI road in 20-40 hour.Some medicines can be used as the time release capsule, are used to make the part medicine in different time is discharged into body.The time release capsule utilizes chemical substance and the chemical reaction between the capsule shell in the gastrointestinal tract to dissolve and discharge medicine.Food, particularly protein and fat, and GI chemistry affect medicine passes the travel speed of stomach.Similarly, medicine comprises the medicine as the time release capsule, can not defer to distribution or dissolution mode accurately during through the GI road.

For example, people since disease, the administration etc. of time early in gastrointestinal tract, can have the chemical substance of measuring more than " normally ", thereby cause the shell of time release capsule faster than normal reaction.Therefore, the time release capsule is to discharge medicine than desired speed faster speed.Yet another person can have the chemical substance that is less than " normally " amount and the shell of time release capsule is got slowly than normal reaction in gastrointestinal tract, thereby discharges medicine with the speed slower than desired speed.

In addition, identical with the conventional medicament that obtains with non-time releasing pattern, the time release capsule needs hold the record daily record or remember that the different time during a day carries out taking of which kind of medicine or administration of patient or caregiver.For example, some medicines must be in the usefulness that is taken at bed time, as be used for the treatment of the NSAIDS of rheumatic arthritis, to produce less gastrointestinal complication, as dyspepsia.The other medicine as antiinflammatory corticosteroid medication predisone, can cause insomnia, thereby typically take in the morning when taking higher dosage.Also have other medicines,, typically take at night so that be that the symptom that often appears at morning is prepared as hydryllin.

The invention provides a kind of being used in that simultaneously the distribution timing mode is carried or the electronically controlled pill or the delivery system of dispense medicament according to presetting by gastrointestinal tract.This presets the distribution timing mode is fixed and is not vulnerable to people's physiological activity and state, emotion, the influence of time administration etc. early.This electronically controlled pill comprises and is used for being stored in controlled delivery of pharmaceutical agents and timing circuit in the medicament reservoir of pill with distribution according to the opening and closing of presetting distribution timing mode by-pass valve control or gate.Electronically controlled pill makes the people can take whole pills basically simultaneously, as 7:00 in the morning, thereby in this day pills again.Be unsuitable for packing into an electronically controlled pill medicine can with other electronically controlled pill synergism, carry out effective dose of whole day and take.

According to the present invention, in special time period, as in 24 hour period, the whole medicines that need take can be provided in one or more electronically controlled pills, and these pills can be taken at one time.These electronically controlled pills can have different distribution timing modes, thereby can obtain the coverage (voverage) of whole day.Similarly, the present invention also provides a kind of therapy system that is used for being undertaken by one or more electronically controlled pills in the identical time two or more medicines of administration.Each pill has independently, presets the distribution timing mode, so that according to distribution mode dispense medicament in vivo.This distribution mode can change to another person from a people to some extent according to everyone health, age, sex, disease etc.In addition, the predetermined instant during the distribution timing mode is present in intravital electronically controlled pill and can be programmed to stop dispense medicament, will take one group of new pill with expectation.This by only make the pill taken recently in vivo dispense medicament prevent unexpected overtreatment.

Therapy system of the present invention makes individuality can take his whole medicines in the substantially the same time, for example in the morning or evening, rather than the different time during special time period (for example, 24 hour period).Therapy system of the present invention also make the caregiver can to each patient of hospital or the habitant of sanatorium (perhaps asylum or veterinary in animal) only carry out once all administrations (that is, per 24 hours once) of medicines every day.System of the present invention thereby avoided the caregiver need wake or bother patient or habitant for the sole purpose of administration, perhaps following the tracks of for the sole purpose of administration may be the different local patient or the habitant of hospital or sanatorium.System of the present invention has also reduced stock, the order of medicine, the burden of following the tracks of and keeping a diary.

Various embodiment of the present disclosure will reference will be made to the accompanying drawings below at this, in the accompanying drawing:

Fig. 1 is the sketch map according to electronically controlled pill of the present invention;

Fig. 2 is the chart that illustrates according to the exemplary preset distribution timing mode of electronically controlled pill of the present invention;

Fig. 3 is the sketch map that is used for the electronically controlled pill of dispense medicament according to the present invention;

Fig. 4 has the sketch map that a plurality of electronics draw the external member of pill, and this electronic pill is for customizing to the particular individual administration.

Illustrate by Fig. 1 according to electronically controlled pill of the present invention or delivery system, and after this be described further at this specially.Electronically controlledpill 100 be independently, the Electronic Control delivery system.Described in detail as follows, electronically controlledpill 100 comprises the programmed electronics according to the distribution mode sustained release mechanism ofdispense medicament.Pill 100 is made by biocompatible materials, is biocompatible therebypill 100 passes the needed time quantum of gastrointestinal tract for it at least.This biocompatible materials is preferably at room temperature stable, thereby pill has long storage life.As used herein and employed in the claims, word " medicine " refers to medicine, non-medicinal substances, contrast agent, gas, fluid, liquid, chemical substance, radiological agent, imaging label, be used to monitor the pick off of people's life indication etc.

Electronically controlledpill 100 comprises shell orhousing 102; Be used to store themedicament reservoir 104 of medicine; Be used to distribute the Electronic Control relief valve or thegate 106 that are stored in the medicine in themedicament reservoir 104; Be used to open and close the control and thetiming circuit 108 ofvalve 106; With battery 109.Control andtiming circuit 108 open andclose valve 106 according to the distribution timing mode that presets that further describes below in the whole distribution time period.To preset the distribution timing mode be pre-programmed and physiological activity that be not vulnerable to the people and state, emotion, the influence of time administration etc. early.

Shell 102 is preferably made by the material that is used to make implantable devices, and implantable devices comprises pacemaker wires and heart prosthesis equipment, decides auxiliary facilities as artificial heart, cardiac valve, intra-aortic oalloon and the heart.These materials comprise Pellet hane  2363 polyether urethane (polyetherurethane) series material that can obtain from Dow Chemical Company and can be from Polymer Technology Group, the Elas thane polyether urethane that Inc. obtains.Other material comprises also can be from Polymer Technology Group, PurSil  and CarboSil  that Inc. obtains.

Valve 106 the distribution time period each constantly the opening of (for example per second) depend in thetiming circuit 110 of control andtiming circuit 108, programme preset the distribution timing mode.Distribution the time period be defined as from when electronically controlledpill 100 is placed into people's oral cavity to the time period that the medicine that is stored in themedicament reservoir 104 all is distributed, perhaps spent one day (24 hour time period).This 24 hour time period slightly conversion to solve stomach and colon in differential absorption.

Shown in the exemplary preset distribution timing mode as shown in Figure 2, at distribution time period A, when D and F, the same amount of distribution medicine in the whole time period of these distribution time periods at each.Therefore, during these distribution time periods,valve 106 is stayed open so that fixed valve openings (or opening frequency) to be provided by control andtiming circuit 108, thereby is distributing time period A, and each of D and F distributed the medicine of precognition amount constantly.Distribute about same amount medicine constantly in each of distribution time period A and F.During distribution time period D, than during distribution time period A and F, distributing more a large amount medicine.

Yet,, when C and E, as shown in Figure 2, distribute not commensurability medicine constantly at each at distribution time period B.Therefore, at distribution time period B, during C and the E, valve open is by control andtiming circuit 108 and changing, to be distributed in the medication amount that each changes constantly.During distribution time period B, the medication amount of distribution increases than previous moment during each constantly; And at distribution time period C, during the E, the medication amount of distribution reduces than previous moment during each constantly.

According to the present invention, during the whole distribution time period, to control and timingcircuit 108 programme makevalve 106 close and by-pass valve control 106 openings with the size of by-pass valve control opening.By by-pass valve control opening size or valve open frequency, as startup by the microfluidic systems of ink-jet printer etc., each medication amount that discharges during (for example per second) constantly that electronically controlledpill 100 can be controlled at the distribution time period exactly.

By the reference time release mode, as by the pattern shown in Fig. 2, be informed in each medication amount that discharges constantly or approximate quantity, can determine drug accumulation amount exactly in the special time period release of distribution time period.For example, can determine in the first six hour of distribution time period, distribution preceding two hours of the time period to the last hour, the drug accumulation amount that discharges during the whole distribution time period etc.Also can determine the medication amount of distributing during the particular moment of distribution time period, as inpill 100 administrations during 15 minutes latter two hours.

Preset the distribution timing mode and programme and to change to another from an electronically controlledpill 100, to have the different distribution timing modes that preset by control andtiming circuit 108 to each pill 100.Therefore, two individualities can utilize two different distribution timing modes that preset to carry out the administration of same medicine.Can adopt look-up table to determine timing mode, one or more features that this look-up table makes the people are with one or more to preset the distribution timing mode relevant.

For example, look-up table can make in age, sex, the body weight etc. one with to preset the distribution timing mode relevant.Then can carry outelectronic pill 100 administrations to the people, thiselectronic pill 100 can be by the programming of determining of distributing in the timing mode of presetting.Therefore,pill 100 of the present invention can adopt different distribution timing modes that Different Individual is carried out administration with a kind of medicine.

In addition, for pills or remember the old young crowd of pills difficulty, preset the distribution timing mode and be a kind of minimizing at special time period, for example the method for pills quantity during 24 hour period.The whole medicines that need be during special time period individuality be carried out administration can be provided in thepill 100, and thispill 100 has and is used for presetting the distribution timing mode according to the amount of pre-determining dispense medicament during the special time period.If the effective dose in pill is not enough, then can adopt two electronically controlled pills distributions with a kind of medicine, one of them pill can not begin dispense medicament till another pill has been distributed its medicine, and promptly its distribution time period passes by or finishes.In addition, the present invention has reduced in as places such as hospital, sanatorium and veterinary institutes and gives pill the needed amount of labour.Give the number of times of pill by minimizing, can also reduce the administration margin of error.

Referring to Fig. 1, control andtiming circuit 108 comprise to presettiming circuit 110, openingtiming device mechanism 112,release controller 114 and thepressure mechanism 116 that the distribution timing mode is programmed.Openingtiming device mechanism 112 starts timing circuit 110.Battery 109 is for control andtiming circuit 108 is powered so that each electromechanical component is being distributed the time period manipulate.

In a preferred embodiment, openingtiming device mechanism 112 has an induced liquid of being used for, micro electronmechanical (MEM) mechanism of the pick off 118 that exists as water, saliva etc.When pill is being taken or during administration, pick off 118 is sensed the existence of liquid, and the signal of telecommunication is sent to timing circuit 110.In an alternative embodiment, opening timing device mechanism is a button, when this button is pressed the signal of telecommunication is sent to timing circuit 110.This button was pressed before human or animal's administration atpill 100 just.

In another embodiment, this can realize the switch closure circuit by making the water-miscible coating's dissolving that separates two electrical pickofves.In another embodiment, by patient or caregiver's manual trigger switch.

In case receive the signal of telecommunication,timing circuit 110 begins distribution is carried out timing the time period and by sending signals and come it is controlled to discharging controller 114.Timing circuit 110 comprises to preset the microprocessor of distribution timing mode programming, it is used for this signal is transmitted (relay) to dischargingcontroller 114, thereby basically according to presetting the distribution timing mode, as by the pattern shown in Fig. 2, dispense medicament during the distribution time period.

The voltage of signals level transmits the valve openings size to be controlled at each medication amount of distributing constantly of distributing the time period according to distributing timing mode by shown in Figure 2 presetting basically.In an alternative embodiment, bytiming circuit 110 to discharging that signal thatcontroller 114 sends only transmits the opening and closing ofvalve 106 and the size of not transmitting valve openings.

Discharge controller 114 and preferably can and generate the micro electronmechanical mechanism of the signal that is used for valve-off 106 and by-pass valve control opening size orvalve 106 opening degrees (according to the voltage level of received signal) toElectronic Control valve 106 from the timing circuit received signal with variable voltage level.Under the simplest situation,discharging controller 114 is to provide voltage to cause its transistor that opens or closes or D/A circuit tovalve 106.

Electronic Control valve 106 preferably can be by the micro electronmechanical mechanism of the signal electric control with variable voltage level.Each voltage level corresponding to the different size opening of valve openings and voltage level (or no-voltage, i.e. no signal) fully corresponding to pent valve 106.Valve 106 in operation with ink-jet printer in adopt according to the valve type of valve open amount distribution ink seemingly.Valve 106 is characterised in that it is a kind of jet valve that is used for controlling miniaturized system micro liquid or gas motion.

In an alternative embodiment,reservoir 104 is microsyringes, thus be applied on the injector push-rod pressure by withshell 102 in the opening needle point that carries out the microsyringe of liquid communication come dispense medicament.In this embodiment, opening replaces valve 106.Yet should consider, place test valve basis presets the drug leakage of distributing during timing mode should not carry out the time of distributing section in the distribution time period to avoid at the needle point place of microsyringe, and/or is used to be controlled at the medication amount of distributing during the distribution time period.

Pressure mechanism 116 is positioned atmedicament reservoir 104 outsides, to guarantee drug targeting valve 106.Under the simplest situation,pressure mechanism 116 is as shown in figs. 1 and 3 biodegradable spring preferably.Pressure mechanism 116 can also be spring, the piston of another kind of type or any mechanism of being used to carry outpressure mechanism 116 functions.That is to say, be used to carry out whenvalve 106 is opened and exert pressure piston-type member 130 is pushed to the function ofvalve 106 to piston-type member 130.Along with piston-type member 130 is shifted tovalve 106, the pressure in thereservoir 104 causes medicine to be distributed as shown in Figure 3.

In an alternative embodiment,medicament reservoir 104 remains under the pressure guaranteeing the correct medication amount of degree of opening distribution according tovalve 106, and need not pressure mechanism 116.Can be by pressure sensor monitoring pressure, this pressure transducer is passed to control andtiming circuit 108 with the pressure that is monitored.If pressure is beyond preset range, thencircuit 108 adjustable valve door openings are to increase or to reduce pressure.Certainly, the pressure ofreservoir 104 can be different for every kind of medicine and be can be dependent on the viscosity of medicine.

What can consider is, can be bycircuit 108 estimation look-up table or other data structures, andcircuit 108 makes pressure, valve openings degree and other parameter correlation such as the time period in the distribution time period, be used for determining by known pressure, for example, the valve openings degree, perhaps vice versa.Based on the information that obtains by the estimation look-up table, the adjustable then seamless power ofcircuit 108, valve openings etc.Can carry out these adjust with follow the trail of basicallypill 100 in, programme preset the distribution timing mode.

According to the present invention, during special time period, for example, during 24 hour time period, all medicines that need take can be provided in one or more electronically controlledpills 100, and described pill is taken simultaneously.Like this, therapy system of the present invention provides by one or more electronically controlledpills 100 and has carried out two or more medicines of administration simultaneously.Eachpill 100 has independently, presets the distribution timing mode so that according to distribution mode dispense medicament in vivo.This distribution mode can change to another person from a people based on everyone health, age, sex, disease etc.

Therapy system of the present invention makes individuality take his whole medicines in same time basically, for example in the morning or evening, rather than the different time during special time period (for example 24 hour time period).Therapy system of the present invention also make the caregiver can to each patient of hospital or the habitant of sanatorium (perhaps asylum or veterinary in animal) only carry out once all administrations of medicines every day.Thereby system of the present invention has avoided the caregiver need wake or bother patient or habitant for the sole purpose of administration, and perhaps going to follow the tracks of for the sole purpose of administration may be the different local patient or the habitant of hospital or sanatorium.

The present invention also provides external member 200 as shown in Figure 4, and this external member 200 has the two or more electronically controlledpills 100 that are encapsulated in the container 202.Eachpill 100 is placed in the recess of container 202 or the recess 201 and eachpill 100 have programming within it independently, preset the distribution timing mode.Thepill 100 of external member 200 is individual (or animal) customization, thereby can provide container 202 to individuality or his caregiver by doctor or pharmacist etc.

Be provided with timing table 204 in container, when eachpill 100 of its indication external member 200 should be taken, for example the time and date in this week.Timing table 204 comprises zone 206, can write each specific date this zone doctor, pharmacist etc. and answer time and the afternoon or the morning of pills 100.May need to take two ormore pills 100 for the special time place fix the date, as shown in Figure 4, wherein each pill has the different pharmaceutical that is stored in wherein and the different distribution timing modes that preset.Like this, individuality can be taken and be indicated as allpills 100 that should take to the special time place that fixes the date, and can not take the same time of anyother pill 100 up to next day.

Because what eachpill 100 of external member 200 had a programming presets the distribution timing mode, evenpills 100 at one time, it also is inessential can interacting from the medicine of each pill 100.For example, apill 100 of external member 200 can get started distribution, and anotherpill 100 of external member 200 can not begin distribution after three hours.

Described embodiments of the invention are exemplary and nonrestrictive, and are not to represent each embodiment of the present invention.Under the situation that does not depart from the spirit or scope of the present invention of illustrating by the character express of following claim and generally acknowledged legally equivalents, can carry out various modifications and change.

Claims (24)

Translated fromChinese

1、一种用于在通过胃肠道时分发药物的药物输送系统(100)，所述系统(100)包括：CLAIMS 1. A drug delivery system (100) for dispensing a drug while passing through the gastrointestinal tract, said system (100) comprising:壳体(102)；housing (102);用于存储所述壳体(102)内的所述药物的贮存器(104)；a reservoir (104) for storing said drug within said housing (102);与所述贮存器(104)液体流通的阀门(106)；和a valve (106) in fluid communication with said reservoir (104); and用于控制所述阀门(106)以打开和关闭所述阀门(106)从而分发所述药物的控制和定时电路(108)，其中用分发定时模式对所述控制和定时电路(108)进行编程，且其中所述药物基本上按照所述分发定时模式分发。a control and timing circuit (108) for controlling the valve (106) to open and close the valve (106) to dispense the drug, wherein the control and timing circuit (108) is programmed with a dispense timing mode , and wherein said drug is dispensed substantially according to said dispense timing pattern.2、根据权利要求1所述的系统(100)，其中所述壳体(102)由选自Pellethane2363聚醚氨基甲酸乙酯系列材料，Elasthane聚醚氨基甲酸乙酯，PurSil，和CarboSil中的至少一种材料制造。2. The system (100) of claim 1, wherein the housing (102) is made of a material selected from the group consisting of Pellethane(R) 2363 polyether urethane series, Elasthane polyether urethane, PurSil(R), and CarboSil Manufactured from at least one of the materials in ®.3、根据权利要求1所述的系统(100)，还包括压力机构(116)，其用于向活塞型部件(130)施加压力以迫使所述贮存器(104)内的所述药物朝向所述阀门(106)。3. The system (100) of claim 1, further comprising a pressure mechanism (116) for applying pressure to a piston-type member (130) to force the drug within the reservoir (104) toward the described valve (106).4、根据权利要求3所述的系统(100)，其中所述压力机构(116)是弹簧。4. The system (100) of claim 3, wherein the pressure mechanism (116) is a spring.5、根据权利要求1所述的系统(100)，还包括用于为所述控制和定时电路(108)供电的电池(109)。5. The system (100) of claim 1, further comprising a battery (109) for powering the control and timing circuit (108).6、根据权利要求1所述的系统(100)，其中所述控制和定时电路(108)包括开启定时器机构(112)，定时电路(110)和释放控制器(114)，其中所述开启定时器机构(112)向所述定时电路(110)发送信号，用于对分发时间段进行计时，且其中所述定时电路(110)向所述释放控制器(114)发送信号，用于控制所述阀门(106)在所述分发时间段期间基本上按照所述分发定时模式分发所述药物。6. The system (100) of claim 1, wherein said control and timing circuit (108) includes an on timer mechanism (112), a timing circuit (110) and a release controller (114), wherein said on A timer mechanism (112) sends a signal to the timing circuit (110) for timing a dispensing period, and wherein the timing circuit (110) sends a signal to the release controller (114) for controlling The valve (106) dispenses the drug substantially according to the dispense timing pattern during the dispense time period.7、根据权利要求1所述的系统(100)，其中所述分发定时模式与要在分发时间段期间每个时刻期间分发的所述药物近似量相关。7. The system (100) of claim 1, wherein the dispense timing pattern is associated with an approximate amount of the drug to be dispensed during each time instant during a dispense time period.8、根据权利要求1所述的系统(100)，其中所述释放控制器(114)控制所述阀门(106)的开口程度。8. The system (100) of claim 1, wherein the release controller (114) controls the degree of opening of the valve (106).9、根据权利要求6所述的系统(100)，其中所述开启定时器机构(112)是具有用于感应液体存在的传感器(118)的微机电(MEM)机构。9. The system (100) of claim 6, wherein the on-timer mechanism (112) is a microelectromechanical (MEM) mechanism having a sensor (118) for sensing the presence of liquid.10、根据权利要求1所述的系统(100)，其中所述贮存器是微型注射器。10. The system (100) of claim 1, wherein the reservoir is a micro-syringe.11、一种药物治疗套件(200)，包括：11. A medical treatment kit (200), comprising:装有用于在通过胃肠道同时输送药物的多个药物输送系统(100)的容器(202)，其中每个系统(100)包括：A container (202) containing a plurality of drug delivery systems (100) for simultaneous drug delivery through the gastrointestinal tract, wherein each system (100) comprises:壳体(102)；housing (102);用于在所述壳体(102)内存储所述药物的贮存器(104)；a reservoir (104) for storing said drug within said housing (102);与所述贮存器(104)液体流通的阀门(106)；和a valve (106) in fluid communication with said reservoir (104); and用于控制所述阀门(106)以打开和关闭所述阀门(106)从而分发所述药物的控制和定时电路(108)，其中用分发定时模式对所述控制和定时电路(108)进行编程，其中所述药物基本上按照所述分发定时模式分发；和a control and timing circuit (108) for controlling the valve (106) to open and close the valve (106) to dispense the drug, wherein the control and timing circuit (108) is programmed with a dispense timing mode , wherein the drug is dispensed substantially according to the dispense timing pattern; and指示何时采用每个药物输送系统(100)的时间表(204)。A schedule (204) indicating when to employ each drug delivery system (100).12、根据权利要求11所述的套件(200)，其中每个药物输送系统(100)还包括压力机构(116)，其用于向活塞型部件(130)施加压力以迫使所述贮存器(104)内的所述药物朝向所述阀门(106)。12. The kit (200) according to claim 11, wherein each drug delivery system (100) further comprises a pressure mechanism (116) for applying pressure to the piston-type member (130) to force the reservoir ( 104) towards the valve (106).13、根据权利要求11所述的套件(200)，其中所述控制和定时电路(108)包括开启定时器机构(112)，定时电路(110)和释放控制器(114)，其中所述开启定时器机构(112)向所述定时电路(110)发送信号，用于对分发时间段进行计时，且其中所述定时电路(110)向所述释放控制器(114)发送信号，用于拉制所述阀门(106)在所述分发时间段期间基本上按照所述分发定时模式分发所述药物。13. The kit (200) of claim 11, wherein said control and timing circuit (108) includes an on timer mechanism (112), a timing circuit (110) and a release controller (114), wherein said on A timer mechanism (112) sends a signal to the timing circuit (110) for timing the dispensing period, and wherein the timing circuit (110) sends a signal to the release controller (114) for pulling controlling said valve (106) to dispense said medication substantially according to said dispense timing pattern during said dispense time period.14、根据权利要求11所述的套件(200)，其中所述分发定时模式与要在时间段期间每个分发时刻期间分发的所述药物近似量相关。14. The kit (200) of claim 11, wherein the dispense timing pattern is associated with an approximate amount of the drug to be dispensed during each dispense moment during a time period.15、根据权利要求11所述的套件(200)，其中所述释放控制器(114)控制所述阀门(106)的开口程度。15. The kit (200) of claim 11, wherein the release controller (114) controls the degree of opening of the valve (106).16、根据权利要求11所述的套件(200)，其中多个所述药物输送系统(100)的至少两个具有不同的分发定时模式。16. The kit (200) of claim 11, wherein at least two of the plurality of drug delivery systems (100) have different dispense timing patterns.17、一种用于进行至少两种药物给药的治疗系统，包括：17. A therapeutic system for administering at least two drugs comprising:用于在通过胃肠道同时按照各自的分发定时模式分发各自药物的第一和第二药物输送系统(100)，每个所述第一和第二系统(100)包括：First and second drug delivery systems (100) for dispensing respective medications while passing through the gastrointestinal tract according to respective timing patterns of dispensing, each of said first and second systems (100) comprising:壳体(102)；housing (102);用于在所述壳体(102)内存储所述药物的贮存器(104)；a reservoir (104) for storing said drug within said housing (102);与所述贮存器(104)液体流通的阀门(106)；和a valve (106) in fluid communication with said reservoir (104); and用于控制所述阀门(106)以打开和关闭所述阀门(106)从而分发所述各自药物的控制和定时电路(108)，其中用所述各自的分发定时模式对所述控制和定时电路(108)进行编程，且其中每个所述系统(100)的所述各自药物基本上按照所述各自分发定时模式分发。a control and timing circuit (108) for controlling said valve (106) to open and close said valve (106) to dispense said respective drug, wherein said control and timing circuit is controlled with said respective dispense timing pattern (108) programmed and wherein said respective medication of each said system (100) is dispensed substantially according to said respective dispense timing pattern.18、根据权利要求17所述的系统，其中所述第一和第二药物输送系统(100)还包括压力机构(116)，其用于向活塞型部件(130)施加压力以迫使所述贮存器(104)内的所述药物朝向所述阀门(106)。18. The system according to claim 17, wherein said first and second drug delivery systems (100) further comprise a pressure mechanism (116) for applying pressure to a piston-type member (130) to force said stored The drug in the container (104) is directed towards the valve (106).19、根据权利要求17所述的系统，其中所述控制和定时电路(108)包括开启定时器机构(112)，定时电路(110)和释放控制器(114)，其中所述开启定时器机构(112)向所述定时电路(110)发送信号，用于对分发时间段进行计时，且其中所述定时电路(110)向所述释放控制器(114)发送信号，用于控制所述阀门(106)在所述分发时间段期间基本上按照所述各自的分发定时模式分发所述药物。19. The system of claim 17, wherein said control and timing circuit (108) includes an on-timer mechanism (112), a timing circuit (110) and a release controller (114), wherein said on-timer mechanism (112) sending a signal to the timing circuit (110) for timing a dispensing period, and wherein the timing circuit (110) sends a signal to the release controller (114) for controlling the valve (106) Dispensing said medication during said dispensing time period substantially according to said respective dispensing timing pattern.20、根据权利要求17所述的系统，其中每个所述各自的分发定时模式与要在分发时间段期间每个时刻期间分发的所述药物近似量相关。20. The system of claim 17, wherein each of said respective dispense timing patterns is associated with an approximate amount of said medication to be dispensed during each time instant during a dispense time period.21、一种用于在通过胃肠道同时分发药物的药物输送系统(100)，所述系统(100)包括：21. A drug delivery system (100) for simultaneously dispensing a drug through the gastrointestinal tract, said system (100) comprising:具有开口的壳体(102)；a housing (102) having an opening;用于在所述壳体(102)内存储所述药物并与所述开口流体连通的贮存器(104)；和a reservoir (104) for storing said drug within said housing (102) and in fluid communication with said opening; and用于控制所述药物分发的控制和定时电路(108)，其中用分发定时模式对所述控制和定时电路(108)进行编程，且其中所述药物基本上按照所述分发定时模式分发。A control and timing circuit (108) for controlling the dispensing of said medication, wherein said control and timing circuit (108) is programmed with a dispense timing pattern, and wherein said medication is dispensed substantially according to said dispense timing pattern.22、根据权利要求21所述的系统(100)，其中所述控制和定时电路(108)包括开启定时器机构(112)，定时电路(110)和释放控制器(114)，其中所述开启定时器机构(112)向所述定时电路(110)发送信号，用于对分发时间段进行计时，且其中所述定时电路(110)向所述释放控制器(114)发送信号，用于控制所述阀门(106)以在所述分发时间段期间基本上按照所述分发定时模式通过所述开口分发所述药物。22. The system (100) of claim 21, wherein said control and timing circuit (108) includes an on timer mechanism (112), a timing circuit (110) and a release controller (114), wherein said on A timer mechanism (112) sends a signal to the timing circuit (110) for timing a dispensing period, and wherein the timing circuit (110) sends a signal to the release controller (114) for controlling The valve (106) is configured to dispense the drug through the opening substantially according to the dispense timing pattern during the dispense time period.23、根据权利要求21所述的系统(100)，其中所述分发定时模式与要在分发时间段期间每个时刻期间分发的所述药物近似量相关。23. The system (100) of claim 21, wherein the dispense timing pattern is associated with an approximate amount of the drug to be dispensed during each time instant during a dispense time period.24、根据权利要求22所述的系统(100)，其中所述释放控制器(114)控制所述阀门(106)的开口程度。24. The system (100) of claim 22, wherein the release controller (114) controls the degree of opening of the valve (106).

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