Laser irradiation device for hyperbaric oxygen chamberThe invention belongs to a laser irradiation device of a hyperbaric oxygen chamber.
The use of hyperbaric oxygen chambers alone or laser alone for the treatment and diagnosis of disease is now a new technology that has developed in recent years.
The hyperbaric oxygen chamber is a large-scale medical apparatus, is a special device for treating diseases by using hyperbaric oxygen, and comprises a small chamber for accommodating a single person, a medium-sized chamber capable of accommodating a plurality of persons at the same time, and a large-scale chamber consisting of a treatment chamber, a transition chamber and an operation chamber. Has unique curative effect on carbon monoxide poisoning, gas gangrene, decompression sickness, acute cerebral anoxia, cerebral edema, cerebral thrombosis, coronary heart disease and other diseases.
Laser is a novel light source appearing in the early sixties, the application of the laser in medicine and biology is rapidly developed, and with the combination of the appearance of optical fibers and ultrasonic laser, a novel technology which can be used for seeing through the depth of soft tissues by laser ultrasonic scanning to 15 cm and particularly combining with photosensitizer hematoporphyrin to diagnose and treat tumors is remarkably developed. The laser is introduced into human body by using optical fibre coupling to make diagnosis and treatment of diseases of digestive system, cardiovascular system, urinary system and bronchus, i.e. utilizes optical property of laser to make diagnosis and utilizes high energy of laser to make treatment.
Practice shows that hyperbaric oxygen and laser have many similar effects on the body, such as improving microcirculation disturbance, pressure on acupuncture points, bacteriostasis and anti-inflammation, promoting healing of intractable tissue ulcer, etc. Thus, the combination of the two can treat a variety of diseases. However, the organic glass inlaid in the hyperbaric oxygen chamber observation window scatters the transmitted laser beam, so that an appropriate aperture angle and a spot position cannot be formed, and the light energy is absorbed to cause the loss of about 30% of the laser output power. The laser tube of the laser is easy to shift and deform or even break under the high pressure of more than one atmosphere, and the instantaneous voltage reaches over kilovolt when gas glow discharge is generated between the cathode and the anode of the laser tube, so that the laser cannot be placed in a high-pressure oxygen chamber for irradiation. Therefore, there are no medical devices in the world that use hyperbaric chambers in combination with lasers.
The invention aims to provide a combined novel hyperbaric oxygen chamber laser irradiation device with a synergistic effect on functions, wherein the combined novel hyperbaric oxygen chamber laser irradiation device can be combined with a photosensitizer in a hyperbaric oxygen chamber to carry out photodynamic action to diagnose and treat malignant tumors and enhance the killing effect on the tumors.
Another object of the present invention is to provide a device having two means for introducing laser light into a hyperbaric oxygen chamber, one means for introducing laser light into the chamber through a laser entrance window, and a light path converter. The other set of the fiber is guided into the cabin through a cable preformed hole of the hyperbaric oxygen cabin by using optical fiber.
Therefore, the device has compact structure, small volume, light weight, easy manufacture, low cost, safe use and convenient operation for medical technicians is the third objective pursued by the invention.
The functional block diagram of the invention is shown in figure 1, a medical laser (1) is arranged in 30 meters outside a hyperbaric oxygen chamber (3), a laser beam (2) is injected into the chamber through optical glass of a hyperbaric oxygen chamber laser incidence window (4), the laser guided into the hyperbaric oxygen chamber enters a cylinder of a light path channel of a light path converter (5) which is arranged in the incidence window chamber, is at the same horizontal position with the light beam of the incidence window and is vertical to the incident light, and when the light path converter (5) is rotated, the laser can be converted into the required light beam, namely: the laser enters a conversion lens barrel (6) without any optical element as a direct light beam, enters a conversion lens barrel (7) embedded with a divergent lens to expand the laser beam (8), enters a conversion lens barrel (9) embedded with a convergent lens to focus the laser beam (10) and then enters an optical fiber (11), enters a conversion lens barrel (12) embedded with a reflector and provided with a reflected light output port to turn the laser in 360 degrees in a vertical space, and the various lasers converted by a light path converter are reflected to a human body irradiation area (14) through a reconversion device (13) arranged on the opposite bulkhead of an incidence window to form a proper aperture angle and light spots. Or the light-guide fiber can enter the cabin through a cable preformed hole of the hyperbaric oxygen cabin and is guided into a human body irradiation area and the cavity for irradiation.
The laser led into the hyperbaric oxygen chamber and the hyperbaric oxygen generate functional synergistic action, and experimental research and clinical observation prove that the effect of the hyperbaric oxygen laser hematoporphyrin derivative for diagnosing and treating the cancer is not the addition of the single effects of the laser hematoporphyrin derivative and the hyperbaric oxygen hematoporphyrin derivative, but is greater than the synergistic action of the addition of the single effects of the laser hematoporphyrin derivative and the hyperbaric oxygen hematoporphyrin derivative. The action mechanism is that the photodynamic action has three factors, namely, a proper amount of photosensitive substance, oxygen in molecular state and light with proper wavelength are required to be contained in a light-receiving target tissue, the three factors are not available, the oxygen content in the tumor tissue is lower than that in normal tissue or is lacking in the tumor tissue, the oxygen is a main factor influencing the killing effect of radiotherapy, chemotherapy and immunotherapy on tumor cells, the oxygen tension, the oxygen content, the oxygen storage amount and the effective dispersion distance radius of the oxygen in the tumor tissue are improved, the arterial blood oxygen partial pressure can be improved by 1770 mm Hg under 2.5ATA (absolute pressure) oxygen, the oxygen in blood plasma can reach 5.3 volume percent and is improved by about 17 times compared with the oxygen breathing under normal pressure, and the effective dispersion radius of the oxygen is improved by 3 times compared with the oxygen breathing under normal pressure. The synergistic effect of hyperbaric oxygen and laser is to diffuse and transport molecular oxygen to the precise point of use of the tumor cells. In the course of photodynamic action, a series of reactions leading to cell necrosis are started from the formation of singlet oxygen, and experimental results further prove the theory of singlet oxygen for photodynamic therapy to treat cancer, and illustrate the earliest and most important mechanism of mitochondrial damage in photodynamic action from the standpoint of singlet oxygen. Secondly, the energy transfer between the photosensitizer hematoporphyrin and oxygen molecules is intermolecular transfer, and the distance relationship between the energy transfer and the molecules is K-1/R6Where K is the probability of energy exchange and B is the intermolecular distance, i.e., the closer the distance, the more significant the improvement in transfer efficiency. The high pressure oxygen causes a significant change in gas volume. At 2.5ATA, the density of molecules is increased by 2.5 times, and the distance between the molecules is reduced by 2.5 times, so that the radiation energy transfer efficiency of molecular oxygen is obviously improved, the quantum yield of singlet oxygen is increased, and the killing effect on tumor cells is enhanced. Currently, the most effective method and approach is hyperbaric lasers to increase the quantum yield of singlet oxygen. Therefore, the combination of the two can treat malignant tumor, surgical burn, inflammation, limb ulcer, fundus disease of the five sense organs system, sudden deafness, periodontal disease, all indications of acupuncture and moxibustion by acupoint irradiation, and the like. The optical fiber is used for performing operations on stomach, duodenum and blood vessel under high pressure oxygen for various difficult and complicated diseases, and the synergistic effect of the two on functions produces unexpected clinical effect.
The technology of the invention is suitable for various medical lasers and all types of large, medium and small hyperbaric oxygen chambers, the optical path conversion device in the chamber ensures that the laser output power loss is less than 5 percent, the laser irradiation mode has various functions of divergent beam expanding, total reflection, focused incident light guide fiber or endoscope light guide beam transmission, laser scalpel and the like, and the optical path conversion system of the laser and the basic structure of the hyperbaric oxygen chamber are greatly improved without influencing the respective original basic functions. The laser is introduced into the cabin from the cable preformed hole of the hyperbaric oxygen cabin by the optical fiber, which is another set of mechanism for realizing the laser irradiation of the hyperbaric oxygen cabin. The optical fiber is inserted into the hyperbaric oxygen chamber, the cross section of the optical fiber at one end outside the chamber is coupled with the output end of the laser resonant cavity by a five-dimensional laser coupler, and the light guide rate is more than 60%. The invention has some additional advantages: simple operation, compact structure and safe use.
Fig. 1 is a general block diagram of a laser irradiation apparatus of a hyperbaric chamber of the present invention.
FIG. 2 is a schematic view showing the laser beam guided into the chamber of FIG. 1 being reflected by the reconversion device to the illumination area via the direct beam of the optical path converter.
Fig. 3 is a view showing that the laser introduced into the chamber of fig. 1 is expanded by the diverging lens of the optical path converter and then reflected to the irradiation area by the re-conversion device.
FIG. 4 is a view showing the laser light introduced into the chamber of FIG. 1 being coupled into an optical fiber or endoscope through a converging lens of the optical path converter to an irradiation area.
Fig. 5 is a gimbal assembly with the reconversion device oriented.
For a better understanding of the present invention, the details of the optimized structure of each subsystem are described below with reference to the accompanying drawings.
According to the figure 1, the laser entrance window (4) of the hyperbaric oxygen chamber is a special window for guiding laser, is different from an observation window of the hyperbaric oxygen chamber and is arranged on the outer side wall of the hyperbaric oxygen chamber body, and the circular window surface of the entrance window is vertical to the ground, namely vertical to the incident direction of laser beams. The outer diameter of the entrance window is 30-180 mm, the inner diameter is 20-160 mm, the optical glass of the double-layer parallel plane is embedded in a metal shell with a screw port in the inner diameter, the distance between the two pieces of glass is 5-10 mm, the inner diameter of the metal shell is spirally connected with the outer diameter of the entrance window outside the cabin, and the metal shell is tightly locked by a sealing washer, so that the optical glass guiding light of the entrance window is convenient to replace. The optical glass may be K9Optical glass with thickness of 6-8 mm and pressure resistance of more than 3.5 kg/cm. K9The optical glass is coated with the medium antireflection film on both sides, so that the absorption and reflection loss of laser can be further reduced, and the medium for coating the medium antireflection film is determined according to the laser performance and wavelength, so that the loss of laser output power after passing through an incident window is less than 5%.
The light path converter (5) for receiving the introduced laser beam in the cabin is formed by connecting a light path channel cylinder (15) made of aluminum alloy with a conversion disc (16), the length of the light path channel cylinder is 6-20 cm, and the outer diameter of the light path channel cylinder is provided with a screw port which is screwed with the inner diameter of the cabin inner part of the entrance window (4). The conversion disk is a four-hole type, its external form is identical to that of converter of biological microscope, four light path conversion lens barrels with identical size are distributed on the conversion disk, and screwed on the conversion disk with four holes, in the four light path conversion lens barrels the divergent lens, convergent lens, total reflector and direct light path without any optical element are respectively inlaid, and the lower portion of one side of lens barrel with total reflection is equipped with a reflected light output container. The sequential conversion disk can convert the laser led into cabin into direct light beam, divergent beam, focused light beam and coupled optical fibre, and can make them turn by 360 deg. in the vertical space by 90 deg. to 120 deg. angle with incident light. The converter is flexible and convenient to rotate, and before and after the light beams in different forms are converted, the light beams keep a certain numerical aperture in the central area of the light path conversion lens barrel.
The light beam passing through the light path converter is emitted to a light path re-conversion device (13) which is arranged opposite to an entrance window on the inner wall of the cabin and is composed of a rotatable total reflection mirror, a divergent lens, a convergent lens and the like at the same horizontal position, and then is emitted to an irradiation area (14), a total reflection mirror (17), a divergent lens (18) and a convergent lens (19) to be coated with a multilayer total reflection dielectric film. The divergent lens enlarges the light spot expanded to the irradiation area, and selects different curvature radiuses of the divergent lens according to the distance to the irradiation area, when the distance between the mirror surface and the irradiation area is about 1.5 to 3 meters, and the diameter of the light spot is 10 millimeters, the curvature radius of the divergent lens is 300 to 500 millimeters.
Fig. 2 shows that the laser beam (2) emitted from the laser (1) passes through the optical glass embedded in the entrance window (4) perpendicular to the laser beam, enters the optical path converter (5) in the capsule, and is emitted from the optical path conversion lens barrel (6) of the conversion disk (16) as can be seen from fig. 2. The optical path conversion lens barrel (6) is not provided with any optical element, but directly emits light beams to a total reflection mirror (17) of a reconversion device (13), or emits the light beams to an irradiation area (14) by expanding or focusing according to requirements.
Fig. 3 is a view showing that the laser introduced into the chamber of fig. 1 is expanded by the diverging lens of the optical path converter and then reflected to the irradiation area by the re-conversion device. As can be seen from fig. 3, the laser guided into the cabin is converted into an expanded laser beam (8) through a light path conversion lens barrel (7) of a divergence lens embedded in the light path converter (5), wherein the light path conversion lens barrel (7) is embedded with a divergence lens with double-layer dielectric films coated on two sides, so that the light beam is expanded and emitted to a divergence lens (18) of a reconversion device (13), or emitted to an irradiation area (14) by secondary beam expansion or focusing according to requirements.
FIG. 4 is a view showing the laser light introduced into the chamber of FIG. 1 being coupled into an optical fiber or endoscope through a converging lens of the optical path converter to an irradiation area. As can be seen from fig. 4, the laser guided into the cabin is changed into a narrow light beam (10) through a light path conversion lens barrel (9) of an embedded convergent lens of a light path converter (5), wherein a convergent lens with double-layer antireflection dielectric film plated on two sides is embedded in the light path conversion cylinder (9), so that the light beam is focused to emit to a reconversion device (13), or the focused light beam is coupled into one or a plurality of optical fibers (11) with 20-400 micron core diameter by a five-dimensional laser coupler, so that the laser is transmitted to an irradiation area (14) in the optical fibers or the optical fiber bundle, and the body cavity irradiation can be carried out.
Fig. 5 is a gimbal assembly for guiding the reconversion device. The lens sleeve (21) of the total reflection lens (17), the divergent lens (18) and the convergent lens (19) is made of metal or plastic, the diameter of the lens is more than 20 mm, and the thickness of the lens is more than 2 mm. The irradiation direction and the irradiation method of the laser beam in the hyperbaric oxygen chamber are controlled by the light path converter (5), the laser beam is emitted to the reconversion device (13), and the proper aperture angle and the spot position of the light are adjusted by means of the rotation of the mirror surface, so that the irradiation direction of the laser beam is adjustable. The rotation of the mirror surface is controlled by 2 steering rods (23) with spheres at the bottoms and capable of rotating freely, the mirror surface is connected to the tops of the steering rods, two sphere parts of the steering rods are fixed by a left clamping plate (24) and a right clamping plate (25), and the moving direction of the mirror surface on the steering rods (23) is controlled by loosening and locking special-shaped screws (26). The optical element of the reconversion device is positioned at the same horizontal position with the optical path converter, is arranged on the inner wall of the cabin opposite to the entrance window, is fixed on the inner wall of the cabin through a base (28) and a cover plate (29) by a base screw (27), moves to the horizontal position vertical to the laser beam through a steering rod (23), and realizes the laser to irradiate the irradiation area by the rotation of a steering rod ball part.
The laser and the hyperbaric oxygen chamber are arranged in a range of 30 meters, one embodiment is that a small medical laser device is integrated on the hyperbaric oxygen chamber, and the large laser device can be tightly connected with a laser incidence window of the hyperbaric oxygen chamber or respectively arranged in two working chambers within 30 meters, or can be made into a movable and liftable laser device according to requirements. The laser in the other working chamber can pass through the window hole with diameter larger than 50 mm specially arranged on the door and window or the wall of the partition wall, the height of the window hole is in the same horizontal position with the laser output end and the laser entrance window of the hyperbaric oxygen chamber, and the laser beam is emitted to the laser entrance window of the hyperbaric oxygen chamber through the hole.
The oxygen supply in the high-pressure oxygen cabin is of an isolated type, an oxygen inhalation mask for discharging oxygen outside the cabin is adopted, when the oxygen concentration in the cabin is controlled to be below 23%, the laser power introduced into the cabin can be basically the same as the laser power used outside the cabin under normal pressure, when the oxygen concentration in the single high-pressure oxygen cabin is mixed and pressurized by adopting oxygen which does not wash the cabin and air, the introduced laser is limited to low power, and the laser is safe to be below 200 milliwatts.
Description of the drawings:
FIG. 1 is a general block diagram of a laser irradiation apparatus for a hyperbaric oxygen chamber
1. The device comprises alaser 2, a laser beam 3, ahyperbaric oxygen chamber 4, alaser entrance window 5, a light path converter 6, a direct light pathconversion lens barrel 7, a light pathconversion lens barrel 8 embedded with a divergent lens, abeam expanding laser 9, a light pathconversion lens barrel 10 embedded with a convergent lens, a focusinglaser 11, a light guide fiber or a sight glasslight guide beam 12, a light pathconversion lens barrel 13 embedded with a total reflector, are-conversion device 14 and an illumination area
FIG. 2, direct beam of laser light directed into hyperbaric oxygen chamber is reflected to the irradiation zone
1.Laser 2, laser beam 3,hyperbaric oxygen chamber 4,laser entrance window 5, optical path converter 6, optical pathconversion lens barrel 13 without optical element,re-conversion device 14,illumination area 15, opticalpath channel cylinder 16, conversion disc 17, holophote
FIG. 3 shows the laser beam guided into the hyperbaric oxygen chamber being diffused, expanded and reflected to the irradiation area
1. The device comprises alaser 2, a laser beam 3, ahyperbaric oxygen chamber 4, alaser entrance window 5, alight path converter 7, a light pathconversion lens cone 8 with a divergent lens embedded therein, expandedbeam laser 13, are-conversion device 14, anillumination area 15, a lightpath channel cylinder 16, aconversion disc 18 and a divergent lens
FIG. 4 shows laser focusing coupling optical fiber introduced into hyperbaric oxygen chamber
1. Alaser 2, a laser beam 3, ahyperbaric oxygen chamber 4, alaser entrance window 5, alight path converter 9, a light pathconversion lens barrel 10 with a built-in convergent lens, a focusinglight beam 11, anoptical fiber 13, are-conversion device 14, anillumination area 15, a lightpath channel cylinder 16, aconversion disc 19 and a convergent lens
FIG. 5 shows a gimbal assembly with a reconversion device oriented
20. Lens 21, lens sleeve 22, pin 23, steering rod 24, left clamping plate 25, right clamping plate 26, special-shaped screw 27, base screw 28, base 29 and cover plate