Movatterモバイル変換

[0]ホーム
URL:

CL2007002078A1 - Process for manufacturing 3 (r) - (2-hydroxy-2,2-dithien-2-ylacetoxy) -1- (3-phenoxypropyl) -1-azoniabicyclo [2.2.2] octane bromide. - Google Patents

Process for manufacturing 3 (r) - (2-hydroxy-2,2-dithien-2-ylacetoxy) -1- (3-phenoxypropyl) -1-azoniabicyclo [2.2.2] octane bromide.

Info

Publication number
CL2007002078A1
CL2007002078A1CL2007002078ACL2007002078ACL2007002078A1CL 2007002078 A1CL2007002078 A1CL 2007002078A1CL 2007002078 ACL2007002078 ACL 2007002078ACL 2007002078 ACL2007002078 ACL 2007002078ACL 2007002078 A1CL2007002078 A1CL 2007002078A1
Authority
CL
Chile
Prior art keywords
dithien
hydroxy
phenoxypropyl
ylacetoxy
azoniabicyclo
Prior art date
Application number
CL2007002078A
Other languages
Spanish (es)
Inventor
Busquets Baque Francesca Pajuelo Lorenzo Nuria
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filedlitigationCriticalhttps://patents.darts-ip.com/?family=37808353&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2007002078(A1)"Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Almirall SafiledCriticalAlmirall Sa
Publication of CL2007002078A1publicationCriticalpatent/CL2007002078A1/en

Links

Classifications

Landscapes

Abstract

Translated fromSpanish

Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(fenoxipropil)-1-azoniabiciclo[2.2.2]octano que comprende reaccionar ester 1-azabiciclo[2.2.2]oct-3(r)ilico del ácido 2-hidroxi-2,2-ditien-2-ilacetico y bromuro de 3-fenoxipropilo, en un solvente consistente en cetonas y éteres cíclicos.Process for manufacturing 3 (r) - (2-hydroxy-2,2-dithien-2-ylacetoxy) -1- (phenoxypropyl) -1-azoniabicyclo [2.2.2] octane bromide comprising reacting ester 1-azabicyclo [2.2 .2] oct-3 (r) ilic of 2-hydroxy-2,2-dithien-2-ylacetic acid and 3-phenoxypropyl bromide, in a solvent consisting of ketones and cyclic ethers.

CL2007002078A2006-07-212007-07-17 Process for manufacturing 3 (r) - (2-hydroxy-2,2-dithien-2-ylacetoxy) -1- (3-phenoxypropyl) -1-azoniabicyclo [2.2.2] octane bromide.CL2007002078A1 (en)

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
ES200601951AES2298049B1 (en)2006-07-212006-07-21 PROCEDURE FOR MANUFACTURING BROMIDE OF 3 (R) - (2-HIDROXI-2,2-DITIEN-2-ILACETOXI) -1- (3-PHENOXIPROPIL) -1-AZONIABICICLO (2.2.2) OCTANO.

Publications (1)

Publication NumberPublication Date
CL2007002078A1true CL2007002078A1 (en)2008-01-25

Family

ID=37808353

Family Applications (1)

Application NumberTitlePriority DateFiling Date
CL2007002078ACL2007002078A1 (en)2006-07-212007-07-17 Process for manufacturing 3 (r) - (2-hydroxy-2,2-dithien-2-ylacetoxy) -1- (3-phenoxypropyl) -1-azoniabicyclo [2.2.2] octane bromide.

Country Status (36)

CountryLink
US (1)US8044205B2 (en)
EP (1)EP2044067B1 (en)
JP (1)JP5279708B2 (en)
KR (1)KR101410198B1 (en)
CN (1)CN101490048B (en)
AR (1)AR061933A1 (en)
AT (1)ATE449096T1 (en)
AU (1)AU2007276395B2 (en)
BR (1)BRPI0711500B1 (en)
CA (1)CA2657679C (en)
CL (1)CL2007002078A1 (en)
CO (1)CO6460740A2 (en)
CY (1)CY1109792T1 (en)
DE (1)DE602007003375D1 (en)
DK (1)DK2044067T3 (en)
EC (1)ECSP099033A (en)
EG (1)EG25727A (en)
ES (2)ES2298049B1 (en)
HR (1)HRP20090652T1 (en)
IL (1)IL196324A (en)
ME (1)ME01773B (en)
MX (1)MX2009000573A (en)
MY (1)MY145285A (en)
NO (1)NO20090811L (en)
NZ (1)NZ573170A (en)
PE (1)PE20081307A1 (en)
PL (1)PL2044067T3 (en)
PT (1)PT2044067E (en)
RS (1)RS51264B (en)
RU (1)RU2439070C2 (en)
SI (1)SI2044067T1 (en)
TW (1)TWI363057B (en)
UA (1)UA96453C2 (en)
UY (1)UY30475A1 (en)
WO (1)WO2008009397A1 (en)
ZA (1)ZA200810051B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
ES2165768B1 (en)1999-07-142003-04-01Almirall Prodesfarma Sa NEW DERIVATIVES OF QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
CA2608561A1 (en)*2007-10-292009-04-29Carl PaluszkiewiczMotorcycle wind deflector accessory support
EP2100599A1 (en)2008-03-132009-09-16Laboratorios Almirall, S.A.Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100598A1 (en)2008-03-132009-09-16Laboratorios Almirall, S.A.Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2510928A1 (en)2011-04-152012-10-17Almirall, S.A.Aclidinium for use in improving the quality of sleep in respiratory patients
EP2666465A1 (en)*2012-05-252013-11-27Almirall, S.A.Novel dosage and formulation
CZ306791B6 (en)2013-10-292017-07-12Zentiva, K.S.An industrially applicable process of preparing aclidinium bromide of high purity
CN103755699A (en)*2014-01-062014-04-30万特制药(海南)有限公司Preparation method of 2-hydroyxl-2,2-dithienyl-2-polyglycolic acid-1-azabicyclo[2, 2, 2] octyl-3(R)-base ester
CN103755698A (en)*2014-01-062014-04-30万特制药(海南)有限公司Technology for preparing aclidinium bromide employing one-pot process
CZ2014188A3 (en)2014-03-262015-10-07Zentiva, K.S.Novel forms of aclidinium chloride and process for preparing thereof
CN104478871B (en)*2014-12-262016-09-07东华大学A kind of choline m receptor antagonist aclidinium bromide and preparation method thereof
PT108370B (en)*2015-03-302018-10-25Hovione Farm S A ACLIDINE BROMETON PREPARATION PROCESS
WO2016162878A1 (en)*2015-04-042016-10-13Harman Finochem LimitedAn advantageous process for preparing 1-azoniabicyclo[2.2.2]octane,3-[(hydroxydi-2-thienylacetyl)oxy]-1-(3¬phenoxypropyl)-, bromide, (3r)- and its novel crystalline form-i
CZ2015257A3 (en)2015-04-162016-10-26Zentiva, K.S.Method of reducing particle size of [(3R)-1-(3-phenoxypropyl)chinuclidin-1-ium-3-yl] 2-hydroxy-2,2-bis(2-thienyl)acetate bromide

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
GB1219606A (en)1968-07-151971-01-20Rech S Et D Applic Scient SogeQuinuclidinol derivatives and preparation thereof
FR2414044A1 (en)1978-01-101979-08-03Pharmindustrie NEW DERIVATIVES OF AZA-1 BICYCLO (2,2,2) OCTANE, USABLE AS MEDICINAL PRODUCTS
FR2539135B1 (en)1983-01-111986-02-28Essilor Int POLYURETHANE HYDROGELS AND MANUFACTURING METHOD
GB8334494D0 (en)1983-12-241984-02-01Tanabe Seiyaku CoCarbostyril derivatives
US4675326A (en)1985-05-081987-06-23Gabriel AmitaiBisquaternary antidotes
US4843074A (en)1988-05-171989-06-27Marion Laboratories, Inc.1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts
DE3931041C2 (en)1989-09-162000-04-06Boehringer Ingelheim Kg Esters of thienyl carboxylic acids with amino alcohols, their quaternization products, processes for their preparation and medicaments containing them
US5610163A (en)1989-09-161997-03-11Boehringer Ingelheim GmbhEsters of thienyl carboxylic acids and amino alcohols and their quaternization products
GB8923590D0 (en)1989-10-191989-12-06Pfizer LtdAntimuscarinic bronchodilators
US5201308A (en)1990-02-141993-04-13Newhouse Michael TPowder inhaler
US5091528A (en)1990-09-121992-02-25Allergan, Inc.6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
DE4108393A1 (en)1991-03-151992-09-17Boehringer Ingelheim Kg NEW ESTERS BI-AND TRICYCLIC AMINO ALCOHOLS, THEIR PREPARATION AND THEIR USE IN MEDICINAL PRODUCTS
GB9119705D0 (en)*1991-09-141991-10-30Pfizer LtdTherapeutic compounds
DE4239402A1 (en)1992-11-241994-05-26Bayer AgMultiple dosage powder inhaler - has acceleration channel and dwell chamber for uniformly high drug dispersion
KR970701174A (en)1994-02-101997-03-17오노다 마사요시 Novel carbamate derivative and medicinal composition containing the same
NO2005012I1 (en)*1994-12-282005-06-06Debio Rech Pharma Sa Triptorelin and pharmaceutically acceptable salts thereof
RO119116B1 (en)1995-04-142004-04-30Glaxo Wellcome Inc. INHALATOR FOR SALMETEROL DOSING
FR2756739B1 (en)1996-12-052000-04-28Astra Ab NEW BUDESONIDE FORMULATION
BR9911351A (en)1998-06-182001-03-13Boehringer Ingelheim Pharma Pharmaceutical formulations for aerosols with two or more active substances
DK1102579T3 (en)1998-08-042003-07-14Jago Res Ag Medical aerosol formulations
GB9902689D0 (en)1999-02-081999-03-31Novartis AgOrganic compounds
DE19921693A1 (en)1999-05-122000-11-16Boehringer Ingelheim PharmaPharmaceutical composition for treating respiratory disorders, e.g. asthma, comprises combination of anticholinergic and beta-mimetic agents having synergistic bronchospasmolytic activity and reduced side-effects
ES2165768B1 (en)1999-07-142003-04-01Almirall Prodesfarma Sa NEW DERIVATIVES OF QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
US7214687B2 (en)1999-07-142007-05-08Almirall AgQuinuclidine derivatives and medicinal compositions containing the same
FR2803378B1 (en)1999-12-292004-03-19Valeo Climatisation MULTI-CHANNEL TUBE HEAT EXCHANGER, PARTICULARLY FOR MOTOR VEHICLES
GB0009592D0 (en)2000-04-182000-06-07Glaxo Group LtdRespiratory combinations
GB0009606D0 (en)2000-04-182000-06-07Glaxo Group LtdTherapeutic combinations
GB0009605D0 (en)2000-04-182000-06-07Glaxo Group LtdMedicaments
GB0009583D0 (en)2000-04-182000-06-07Glaxo Group LtdRespiratory formulations
WO2002036106A2 (en)2000-10-312002-05-10Boehringer Ingelheim Pharma Gmbh & Co. KgNovel medicament compositions based on anticholinergics and corticosteroids
US20030158196A1 (en)2002-02-162003-08-21Boehringer Ingelheim Pharma Gmbh Co. KgPharmaceutical compositions based on anticholinergics and EGFR kinase inhibitors
US6620438B2 (en)2001-03-082003-09-16Boehringer Ingelheim Pharma KgPharmaceutical compositions based on anticholinergics and NK1-receptor antagonists
DE10062712A1 (en)2000-12-152002-06-20Boehringer Ingelheim Pharma New drug compositions based on anticholinergics and corticosteroids
US20020122773A1 (en)2000-12-202002-09-05Michel PairetPharmaceutical compositions based on anticholinergics and dopamine agonists
US7776315B2 (en)2000-10-312010-08-17Boehringer Ingelheim Pharma Gmbh & Co. KgPharmaceutical compositions based on anticholinergics and additional active ingredients
US20020183292A1 (en)2000-10-312002-12-05Michel PairetPharmaceutical compositions based on anticholinergics and corticosteroids
US6608054B2 (en)2001-03-202003-08-19Boehringer Ingelheim Pharma KgPharmaceutical compositions based on anticholinergics and endothelin antagonists
US20020193393A1 (en)2001-03-072002-12-19Michel PairetPharmaceutical compositions based on anticholinergics and PDE-IV inhibitors
US20020151541A1 (en)2000-10-312002-10-17Michel PairetPharmaceutical compositions containing tiotropium salts and antihistamines and their use
US20020137764A1 (en)2000-10-312002-09-26Karin DrechselInhalable formulation of a solution containing a tiotropium salt
US20020193392A1 (en)2000-11-132002-12-19Christel SchmelzerPharmaceutical compositions based on tiotropium salts of salts of salmeterol
DE10056104A1 (en)2000-11-132002-05-23Boehringer Ingelheim PharmaDrug compositions useful for treatment of respiratory diseases, especially asthma and chronic obstructive pulmonary disease comprises tiotropium salts and salmeterol salts
US20100310477A1 (en)2000-11-282010-12-09Boehringer Ingelheim Pharma Gmbh & Co. Kg.Pharmaceutical compositions based on anticholingerics and additional active ingredients
AU2002228015B2 (en)2000-12-222007-08-23Almirall, S.A.Quinuclidine carbamate derivatives and their use as M3 antagonists
DE60121813T2 (en)*2000-12-282007-09-20Almirall Ag NEW CHINUCLIDINE DERIVATIVES AND MEDICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
US20020189610A1 (en)2001-02-012002-12-19Karl-Heinz BozungPharmaceutical compositions containing an ipratropium salt and a betamimetic
DE10104367A1 (en)2001-02-012002-08-08Boehringer Ingelheim Pharma Medicinal compositions containing betamimetics with fewer side effects
US20020179087A1 (en)2001-02-012002-12-05Karl-Heinz BozungPharmaceutical compositions containing an oxitropium salt and a betamimetic
DE10104370A1 (en)2001-02-012002-08-08Boehringer Ingelheim Pharma Medicinal compositions with fewer side effects
DE10130371A1 (en)2001-06-232003-01-02Boehringer Ingelheim Pharma New drug compositions based on anticholinergics, corticosteroids and betamimetics
US20030018019A1 (en)2001-06-232003-01-23Boehringer Ingelheim Pharma KgPharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
ES2206021B1 (en)*2002-04-162005-08-01Almirall Prodesfarma, S.A. NEW DERIVATIVES OF PIRROLIDINIO.
ES2195785B1 (en)2002-05-162005-03-16Almirall Prodesfarma, S.A. NEW DERIVATIVES OF PIRIDAZIN-3 (2H) -ONA.
ES2204295B1 (en)*2002-07-022005-08-01Almirall Prodesfarma, S.A. NEW DERIVATIVES OF QUINUCLIDINE-AMIDE.
ES2211315B1 (en)2002-11-122005-10-16Almirall Prodesfarma, S.A. NEW TRICYCLE COMPOUNDS.
ES2211344B1 (en)2002-12-262005-10-01Almirall Prodesfarma, S.A. NEW DERIVATIVES OF PIRIDAZIN-3 (2H) -ONA.
US20050026948A1 (en)2003-07-292005-02-03Boehringer Ingelheim International GmbhMedicaments for inhalation comprising an anticholinergic and a betamimetic
EP1651236A1 (en)2003-07-292006-05-03Boehringer Ingelheim International GmbHCombination of an anticholinergic and a steroid and its use to treat respiratory disorders by inhalation
US20050026887A1 (en)2003-07-292005-02-03Boehringer Ingelheim International GmbhMedicaments for inhalation comprising an anticholinergic and a steroid
US20050026886A1 (en)2003-07-292005-02-03Boehringer Ingelheim International GmbhMedicaments for inhalation comprising an anticholinergic and a PDE IV inhibitor
US20050025718A1 (en)2003-07-312005-02-03Boehringer Ingelheim International GmbhMedicaments for inhalation comprising an anticholinergic and a betamimetic
ES2232306B1 (en)2003-11-102006-08-01Almirall Prodesfarma, S.A. NEW DERIVATIVES OF PIRIDAZIN-3 (2H) -ONA.
ES2239546B1 (en)2004-03-152006-12-01Almirall Prodesfarma, S.A. NEW QUATERNIZED QUINUCLIDINE ESTERS.
ES2257152B1 (en)2004-05-312007-07-01Laboratorios Almirall S.A. COMBINATIONS THAT INCLUDE ANTIMUSCARINIC AGENTS AND BETA-ADRENERGIC AGONISTS.
EP2100599A1 (en)2008-03-132009-09-16Laboratorios Almirall, S.A.Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100598A1 (en)2008-03-132009-09-16Laboratorios Almirall, S.A.Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease

Also Published As

Publication numberPublication date
AU2007276395A1 (en)2008-01-24
CN101490048A (en)2009-07-22
PT2044067E (en)2009-12-21
EP2044067A1 (en)2009-04-08
ECSP099033A (en)2009-02-27
AR061933A1 (en)2008-10-01
ES2298049A1 (en)2008-05-01
SI2044067T1 (en)2010-03-31
NO20090811L (en)2009-02-20
US20090299042A1 (en)2009-12-03
PE20081307A1 (en)2008-09-17
HRP20090652T1 (en)2010-01-31
PL2044067T3 (en)2010-04-30
ZA200810051B (en)2009-11-25
DK2044067T3 (en)2010-02-01
KR20090031578A (en)2009-03-26
RU2439070C2 (en)2012-01-10
DE602007003375D1 (en)2009-12-31
RS51264B (en)2010-12-31
IL196324A0 (en)2009-09-22
MX2009000573A (en)2009-01-29
UY30475A1 (en)2008-01-02
JP2009544591A (en)2009-12-17
TWI363057B (en)2012-05-01
JP5279708B2 (en)2013-09-04
ES2298049B1 (en)2009-10-20
CA2657679A1 (en)2008-01-24
NZ573170A (en)2010-12-24
UA96453C2 (en)2011-11-10
ME01773B (en)2010-12-31
MY145285A (en)2012-01-13
ATE449096T1 (en)2009-12-15
BRPI0711500A2 (en)2011-11-01
WO2008009397A8 (en)2009-01-22
TW200821307A (en)2008-05-16
WO2008009397A1 (en)2008-01-24
RU2009105827A (en)2010-08-27
CY1109792T1 (en)2014-09-10
AU2007276395B2 (en)2012-03-08
CN101490048B (en)2011-06-29
CO6460740A2 (en)2012-06-15
IL196324A (en)2012-12-31
HK1124051A1 (en)2009-07-03
ES2336045T3 (en)2010-04-07
KR101410198B1 (en)2014-06-19
CA2657679C (en)2014-10-21
EG25727A (en)2012-06-11
US8044205B2 (en)2011-10-25
BRPI0711500B1 (en)2014-09-16
EP2044067B1 (en)2009-11-18

Similar Documents

PublicationPublication DateTitle
CL2007002078A1 (en) Process for manufacturing 3 (r) - (2-hydroxy-2,2-dithien-2-ylacetoxy) -1- (3-phenoxypropyl) -1-azoniabicyclo [2.2.2] octane bromide.
GR1006045B (en)Combination comprising antimuscarinic agents and beta-adrenergic agonists
ATE430153T1 (en) METHOD FOR REDUCING ALPHA, BETA-UNSATURATED KETONES IN OPIOID COMPOSITIONS
WO2010066034A8 (en)Narcotic drug formulations with decreased abuse potential
WO2006113881A3 (en)Method of using stroma cells from cord blood to expand and engraft nucleated cells from cord blood
PL2331456T3 (en)Process for purifying hydrogen chloride
TN2009000249A1 (en)Mapk/erk kinase inhibitors
CL2012001117A1 (en) Composition comprising multipotential stem cells from the biliary tree of a mammal; method of obtaining multipotent cells from a mammal capable of differentiating into multiple endothermic lineages.
DOP2009000089A (en) MAPK / ERK CINASE INHIBITORS
DE602007012357D1 (en) METHOD AND DEVICE FOR HUMIDIFYING A CONTACT LENS
WO2014059326A3 (en)Methods of identifying compounds for treating depression and other related diseases
WO2012168363A3 (en)Minimize downtime with immediate upgrade of data in databases
ATE529382T1 (en) IMPROVED PROCESS FOR PRODUCING HYDROGEN ACID
EA201001032A1 (en) TABLETS WITH FILM COATING CONTAINING AS AN ACTIVE COMPONENT OF DROSPIRENON AND METHOD OF OBTAINING THEM
GB2472369A (en)Method for eliminating carbon dioxide from waste gases
Kim et al.Factors affecting the preparation for later life according to age in production workers
LauraA Systematic Method for Interpreting Novel Compounds
ATE470960T1 (en) ACID STATUS INDICATOR, BATTERY, METHOD FOR PRODUCING AN ACID STATUS INDICATOR AND METHOD FOR PRODUCING A BATTERY
AR066540A1 (en) COMPOUNDS 273
[8]ページ先頭
©2009-2025 Movatter.jp