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CA2317747A1 - Biodegradable polyester amides with block-shaped polyester and polyamide segments - Google Patents

Biodegradable polyester amides with block-shaped polyester and polyamide segments
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Publication number
CA2317747A1
CA2317747A1CA 2317747CA2317747ACA2317747A1CA 2317747 A1CA2317747 A1CA 2317747A1CA 2317747CA2317747CA 2317747CA 2317747 ACA2317747 ACA 2317747ACA 2317747 A1CA2317747 A1CA 2317747A1
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Canada
Prior art keywords
ester
block
acid
amide
terminated
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Abandoned
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CA 2317747
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French (fr)
Inventor
Ralf Timmermann
Michael Voigt
Wolfgang Schulz-Schlitte
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Bayer AG
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Individual
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Publication of CA2317747A1publicationCriticalpatent/CA2317747A1/en
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Abstract

The invention relates to block-shaped polyester amides with an amide or ester structure, containing the following monomers: aliphatic dialcohols or cycloaliphatic diols and/or aliphatic dicarboxylic acid also in the form of a corresponding ester and/or aromatic dicarboxylic acids also in the from of a corresponding ester and/or hydroxy carboxylic acids and lactone and/or amino alcohols and/or cyclic lactames, and/or .omega. amino carboxylic acids and/or mixtures (1:1 salts) of dicarboxylic acids and diamines, whereby the polyester amides can be obtained by polycondensation of a hydroxy, acid or ester terminated ester block and an amino acid or ester terminated amide block, whereby the ester content of the polyester amide is 20-80 wt. % and the amide content is 80-20 %.

Description

Biodegradable polyesteramides having nolyester segments and polyamide settments of block construction Compostable aliphatic polyesteramides are known (for example, EP-A 641 817).
Compostable aliphatic-aromatic polyesteramides are also described (WO 92/21689, WO
96/21690, WO
96/21691 and WO 96/21692.
The structures described are constructed purely statistically and have no segmented block construction at all.
Polyesteramides of block construction are also known. Polyesteramides of block construction obtained by transesterification-/transamidation reactions of higher-molecular weight polyamides with higher molecular weight polyesters are described in EP-A 717 064, JP 0 430 6229, JP 0 701 0988 and JP 0 715 7557. Such reactions are reproducible only with difficulty, as the extent of the reactions depends very greatly on the operating conditions.
Polyesteramides having such a block construction are not however sufficiently biodegradable.
The object of this invention is to provide segmented polyesteramides in block form, which are completely degradable biologically and by enzymes.
It has been found that acid-, ester-, hydroxyl- or amine-terminated short oligomers having amide or ester structures and molecular weights of not more than 3,000 are reacted with one another under mild conditions in such a way that this segmented structure is preserved.
The invention accordingly provides polyesteramides of block construction and having an amide structure or ester structure, which polyesteramides can be synthesised from the following monomers:
.' - aliphatic dialcohols having preferably 2 to 12 carbon atoms, such as ethylene glycol, diethylene glycol, 1,4-butanediol, 1,3-propanediol, 1,6-hexanediol and cycloaliphatic diols such as cyclohexanedimethanol, and/or - aliphatic dicarboxylic acid having preferably 2 to 12 carbon atoms, such as oxalic acid, succinic acid, adipic acid, and others, also in the form of its respective esters (methyl, ethyl, etc.), and/or - aromatic dicarboxylic acids, such as terephthalic acid, isophthalic acid, phthalic acid, and others, also in the form of their respective esters (methyl, ethyl, etc.), and/or - Hydroxycarboxylic acids having preferably 2 to 12 C atoms, lactones, such as caprolactone and others, and/or - aminoalcohols having preferably 2 to 12 C atoms, such as ethanolamine, propanolamine, etc., and/or - cyclic lactams, such as ~-caprolactam or lauryl lactam, etc., and/or - w-aminocarboxylic acids, such as aminocaproic acid, etc., and/or - mixtures (1 : 1 salts) of dicarboxylic acids having preferably 2 to 12 C
atoms, such as adipic acid, succinic acid, terephthalic acid, etc., and of diamines having preferably 2 to 10 C atoms in the alkyl group, such as hexamethylenediamine, diaminobutane, etc., the polyesteramides being obtainable by polycondensation of a hydroxyl-, acid-or ester-terminated ester block and of an amino acid-terminated or ester-terminated amide block, the ester content of the polyesteramide being from 20 to 80 wt.%, preferably from 30 to 70 wt.%, and the amide content being from 80 to 20 wt.%, preferably from 70 to 30 wt.%.
For the synthesis of the polyesteramides, it is preferable to use caprolactam or AH salt or mixtures thereof with butanediol and/or diethylene glycol and terephthalic acid (ester) and adipic acid (ester).
The short blocks produced, consisting of amide units or ester units, are prepared from the monomers according to methods known in polymer chemistry, by selecting the monomeric composition. For example, a polyamide block having a molecular weight of 598 and with acid end groups can be prepared from 3 mol adipic acid and 2 mol hexamethylenediamine.
Equally, a polyester block having a molecular weight of 490 can be prepared from 2 mol adipic acid and 3 mol butanediol. If these two blocks are now reacted with one another in stoichiometric ratio, one obtains polyesteramides of block construction, containing short amide segments and ester segments, which do not interfere with the biodegradation process.
In the preparation of the short blocks and also of the polyesteramides, suitable catalysts can be used in order to catalyse the esterification or amidation reaction.
These include, for example, titanium compounds for the esterifications and phosphorus compounds for the amidation reactions. These catalysts are in accordance with prior art.
They must not, however, subsequently restrict the use of the degradable polymer in the compost and they must not interfere with the biodegradability. For this reason catalysts based on heavy metals such as antimony or lead, for example, are completely dispensed with.
The polyesteramides prepared in this way are completely biodegradable and compostable according to DIN 54 900 and have very good mechanical properties.
The capacity of a polymer to be decomposed by enzymes is termed enzymic degradability. Here, the bonds by which the structural units of the polymer are linked together are broken. The resulting breakdown products are the monomers of the polymer and its oligomers. The enzymic degradation of the polymer leads to a decrease in its molecular weight. Enzymic degradation differs from biodegradation in that it does not as a rule lead to naturally-occurnng metabolites.
In principle, all enzymes which are capable of breaking the bonds present in the polymer can be used as enzymes which degrade the biodegradable polymers. In selecting the enzymes, care is to be taken to ensure that these are capable of rapidly and completely degrading the polymer. The degradation is carned out in an aqueous solution, which can be buffered. The pH can be between 3 and 11, is preferably between 5 and 9 and particularly preferably between 6 and 8. The temperature at which the enzymic degradation is carried out can be between 5°C and 95°C, is preferably between 20°C and 70°C and particularly preferably between 30°C and 50°C.
The following are examples of buffers which can be used according to the invention:
citrate, acetate, phosphate, formate, carbonate, tris(hydroxymethyl)aminomethane, triethanolamine, imidazole, oxalate, tartrate, fumarate, maleate, phthalate, succinate, ethylenediamine, as well as mixtures of several of these. Preferably acetate, phosphate and citrate are used as buffers.
The procedure is to add the enzyme and polymer to the aqueous solution. The biodegradable polymer can be added in the form of a film, sheet or granules.
Mouldings can be added as an intact whole or can be comminuted. Coated or bonded materials, or materials in the case of which coatings have been applied or bonds produced using biodegradable polymers, such as, for example, paper or cardboard, as well as coated paper or coated cardboard, can be added either as an intact whole or in comminuted form to the enzyme-containing solution.
The aqueous enzyme-containing solution can also be applied by spraying, or sprayed, onto the coating to be degraded or onto the moulding to be degraded.
The enzymes used can be lipolytic and/or proteolytic enzymes.
For the purpose of this invention, lipases, cutinases, esterases, phospholipases and lysophospholipases are referred to as lipolytic enzymes. The lipolytic enzymes originate preferably from microorganisms. They originate in particular from bacteria, fizngi or yeasts. The lipolytic enzymes may also be of vegetable or animal origin.
For the purpose of this invention, proteases are referred to as proteolytic enzymes.
These originate preferably from bacteria of the genus Bacillus; proteases of the organisms Bacillus alcalophilus and Bacillus licfheniformis are particularly preferred.
They may also originate from fizngi or from plants.
The joint use of lipolytic and proteolytic enzymes as well as of lipolytic enzymes of varying specificity, which can lead to synergistic effects, is according to the invention.
The addition of metal ions such as, for example, sodium ions or calcium ions, which accelerate the enzymic degradability, is also according to the invention. The addition of auxiliary substances such as anionic or nonionic surfactants such as, for example, sec.
alcoholethoxylates, is also according to the invention.
Compostability is the capacity of a polymeric material to be biodegraded during a composting process. For the polymeric material to be regarded as compostable, it has to be proved by means of standard methods that it can be biodegraded in a composting system and that compost of flawless quality can be produced (according to DIN

900).
The biodegradation of a material is a process which is caused by biological activity and which leads to naturally-occurnng metabolic end products, with alteration of the chemical structure of the material (according to DIN 54 900).
A polymeric material is biodegradable if all organic constituents are subject to a complete biological degradation, which is determined by standard processes (according to DIN 54 900).
The mixtures according to the invention may contain in addition from 0 to 80 wt.% of conventional additives, for example, inorganic fillers and reinforcing materials (for example, glass fibres, carbon fibres) and mineral fillers (for example, talc, mica, chalk, kaolin, wollastonite, gypsum, quartz, dolomite and others), UV stabilisers, antioxidants, pigments, dye, nucleating agents, accelerators or inhibitors of crystallisation, flow-promoting agents, lubricants, mould release agents, flameproofing agents.
The polyesteramides according to the invention may further contain from 0.05 to 5 wt.%, preferably from 0.1 to 1 wt.%, of branching agents. These branching agents can be, for example, trifunctional alcohols, such as trimethylolpropane or glycerol, tetrafunctional alcohols such as pentaerythritol, trifunctional carboxylic acids such as citric acid or even tri- or tetrafunctional hydroxycarboxylic acids.
Examples Example 1 Preparation of a hydroxyl-terminated oligoester block having a molecular weight of 292 g (2 mol) adipic acid and 270 g (3 mol) butanediol are heated together at 250°C
under nitrogen. After 1 hour a water jet vacuum is applied and after 2.5 hours, an oil pump vacuum. Water is distilled off. After a polycondensation time of 4 hours, a colourless wax having a hydroxyl value of 21 is obtained.
Example 2 Preparation of an ester-terminated oligoester block having a molecular weight of 1038 696 g (4 mol) dimethyl adipate and 270 g (3 mol) butanediol are heated together at 250°C under nitrogen. After 1 hour a water jet vacuum is applied and after 2.5 hours, an oil pump vacuum. Methanol is distilled off. After a polycondensation time of 4 hours, a colourless wax is obtained.
Example 3 Preparation of an ester-terminated amide block having a molecular weight of 522 g (3 mol) dimethyl adipate and 180 g (2 mol) hexamethylenediamine are heated together at 250°C under nitrogen. After 1 hour a water jet vacuum is applied and after 2.5 hours, an oil pump vacuum. Methanol is distilled off. After a polycondensation time of 3 hours, a colourless wax is obtained.
Example 4 Preparation of an amino-terminated amide block having a molecular weight of _g_ 292 g (2 mol) adipic acid and 348 g (3 mol) hexamethylenediamine are heated together at 250°C under nitrogen. After 1 hour a water jet vacuum is applied and after 2.5 hours, an oil pump vacuum. Water is distilled off. After a polycondensation time of 3 hours, a colourless wax is obtained.
Example 5 Preparation of a polyesteramide from the individual blocks 626 g (1 mol) of an ester-terminated amide block as in Example 3 and 490 g (1 mol) of a hydroxyl-terminated ester block as in Example 1 are heated together at 190°C under nitrogen. After 1 hour a water jet vacuum is applied and after 2.5 hours, an oil pump vacuum. Methanol is distilled off. After a polycondensation time of 7 hours, a colourless polymer having a melting point of 136°C is obtained. The polymer obtained has good mechanical properties and is biodegradable according to DIN 54 900.

Claims (4)

Claims
1. Polyesteramides of block construction, have an amide structure or ester structure, which contain the following monomers:
- aliphatic dialcohols or cycloaliphatic alcohols and/or - aliphatic dicarboxylic acid, also in the form of its respective esters and/or - aromatic dicarboxylic acids, also in the form of their respective esters and/or - hydroxycarboxylic acids, lactones and/or - aminoalcohols and/or - cyclic lactams and/or - .omega.-aminocarboxylic acids and/or - mixtures (1 : 1 salts) of dicarboxylic acids and diamines, the polyesteramides being obtainable by polycondensation of a hydroxyl-, acid-or ester-terminated ester block and of an amino acid-terminated or ester-terminated amide block, the ester content of the polyesteramide being between 20 and 80 wt.% and the amide content being 80 to 20 wt.%.
2. Polyesteramides according to claim 1, which have been formed by polycon-densation of a mixture of 2 or more hydroxyl-, acid- or ester-terminated ester blocks and a mixture of 2 or more of an amino-, acid- or ester-terminated amide blocks.
3. Use of the polyesteramide according to claims 1 and 2 for the production of sheets, injection-moulded articles, nonwoven fabrics, fibres or foams.
4. Films, sheets, injection-moulded articles, nonwoven fabrics, fibres and foams, produced from polyesteramides according to claims 1 and 2.
CA 23177471998-01-101998-12-29Biodegradable polyester amides with block-shaped polyester and polyamide segmentsAbandonedCA2317747A1 (en)

Applications Claiming Priority (3)

Application NumberPriority DateFiling DateTitle
DE1998100698DE19800698A1 (en)1998-01-101998-01-10 Biodegradable polyester amides with block-like polyester and polyamide segments
DE19800698.51998-01-10
PCT/EP1998/008489WO1999035179A1 (en)1998-01-101998-12-29Biodegradable polyester amides with block-shaped polyester and polyamide segments

Publications (1)

Publication NumberPublication Date
CA2317747A1true CA2317747A1 (en)1999-07-15

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Application NumberTitlePriority DateFiling Date
CA 2317747AbandonedCA2317747A1 (en)1998-01-101998-12-29Biodegradable polyester amides with block-shaped polyester and polyamide segments

Country Status (9)

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EP (1)EP1045874A1 (en)
JP (1)JP2002500252A (en)
KR (1)KR20010033975A (en)
CN (1)CN1285853A (en)
AU (1)AU2417599A (en)
CA (1)CA2317747A1 (en)
DE (1)DE19800698A1 (en)
NO (1)NO20003469D0 (en)
WO (1)WO1999035179A1 (en)

Cited By (33)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US8075872B2 (en)2003-08-062011-12-13Gruenenthal GmbhAbuse-proofed dosage form
US8080617B2 (en)2005-06-162011-12-20Dow Global Technologies LlcAliphatic polyester-amide compositions and a process for producing the same
US8114383B2 (en)2003-08-062012-02-14Gruenenthal GmbhAbuse-proofed dosage form
US8114384B2 (en)2004-07-012012-02-14Gruenenthal GmbhProcess for the production of an abuse-proofed solid dosage form
US8192722B2 (en)2003-08-062012-06-05Grunenthal GmbhAbuse-proof dosage form
US8383152B2 (en)2008-01-252013-02-26Gruenenthal GmbhPharmaceutical dosage form
US8722086B2 (en)2007-03-072014-05-13Gruenenthal GmbhDosage form with impeded abuse
US9161917B2 (en)2008-05-092015-10-20Grünenthal GmbHProcess for the preparation of a solid dosage form, in particular a tablet, for pharmaceutical use and process for the preparation of a precursor for a solid dosage form, in particular a tablet
US9636303B2 (en)2010-09-022017-05-02Gruenenthal GmbhTamper resistant dosage form comprising an anionic polymer
US9655853B2 (en)2012-02-282017-05-23Grünenthal GmbHTamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
US9675610B2 (en)2002-06-172017-06-13Grünenthal GmbHAbuse-proofed dosage form
US9737490B2 (en)2013-05-292017-08-22Grünenthal GmbHTamper resistant dosage form with bimodal release profile
US9855263B2 (en)2015-04-242018-01-02Grünenthal GmbHTamper-resistant dosage form with immediate release and resistance against solvent extraction
US9872835B2 (en)2014-05-262018-01-23Grünenthal GmbHMultiparticles safeguarded against ethanolic dose-dumping
US9913814B2 (en)2014-05-122018-03-13Grünenthal GmbHTamper resistant immediate release capsule formulation comprising tapentadol
US9925146B2 (en)2009-07-222018-03-27Grünenthal GmbHOxidation-stabilized tamper-resistant dosage form
US10058548B2 (en)2003-08-062018-08-28Grünenthal GmbHAbuse-proofed dosage form
US10064945B2 (en)2012-05-112018-09-04Gruenenthal GmbhThermoformed, tamper-resistant pharmaceutical dosage form containing zinc
US10080721B2 (en)2009-07-222018-09-25Gruenenthal GmbhHot-melt extruded pharmaceutical dosage form
US10154966B2 (en)2013-05-292018-12-18Grünenthal GmbHTamper-resistant dosage form containing one or more particles
US10201502B2 (en)2011-07-292019-02-12Gruenenthal GmbhTamper-resistant tablet providing immediate drug release
US10300141B2 (en)2010-09-022019-05-28Grünenthal GmbHTamper resistant dosage form comprising inorganic salt
US10335373B2 (en)2012-04-182019-07-02Grunenthal GmbhTamper resistant and dose-dumping resistant pharmaceutical dosage form
WO2019147458A1 (en)2018-01-232019-08-01Eastman Chemical CompanyNovel polyesteramides, processes for the preparation thereof, and polyesteramide compositions
WO2019147676A1 (en)2018-01-232019-08-01Solutia Inc.Interlayers comprising polyesteramide compositions
US10449547B2 (en)2013-11-262019-10-22Grünenthal GmbHPreparation of a powdery pharmaceutical composition by means of cryo-milling
US10624862B2 (en)2013-07-122020-04-21Grünenthal GmbHTamper-resistant dosage form containing ethylene-vinyl acetate polymer
US10695297B2 (en)2011-07-292020-06-30Grünenthal GmbHTamper-resistant tablet providing immediate drug release
US10729658B2 (en)2005-02-042020-08-04Grünenthal GmbHProcess for the production of an abuse-proofed dosage form
US10842750B2 (en)2015-09-102020-11-24Grünenthal GmbHProtecting oral overdose with abuse deterrent immediate release formulations
US11224576B2 (en)2003-12-242022-01-18Grünenthal GmbHProcess for the production of an abuse-proofed dosage form
WO2023023446A1 (en)2021-08-192023-02-23Solutia Inc.High molecular weight polyesteramides
US11844865B2 (en)2004-07-012023-12-19Grünenthal GmbHAbuse-proofed oral dosage form

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
DE10027905A1 (en)*2000-06-062001-12-13Bayer AgBiodegradable molding composition, useful for the production of plant covers, disposable cutlery, casings or packaging, comprises a biodegradable polymer and a mineral and/or a renewable material,
DE10206924B4 (en)*2002-02-192005-12-15Papierfabrik Schoeller & Hoesch Gmbh & Co. Kg Heat-sealable filter materials
SA07280459B1 (en)2006-08-252011-07-20بيورديو فارما إل. بي.Tamper Resistant Oral Pharmaceutical Dosage Forms Comprising an Opioid Analgesic
CN101450990B (en)*2007-12-062011-06-08中国纺织科学研究院Acidic dyeable polyester and method for preparing acidic dyeable polyester and fiber thereof
CN101293958B (en)*2008-06-192011-11-16武汉华丽生物材料有限公司Appropriately crosslinked biodegradable polyester-amides random block copolymer
CN101293957B (en)*2008-06-192011-08-03武汉华丽环保科技有限公司Appropriately crosslinked biodegradable polyester-amides random block copolymer and synthesizing method thereof
CA2736393A1 (en)*2008-10-152010-04-22Medivas, LlcBiodegradable proline-based polymers
CN101942708B (en)*2010-08-192012-11-21中国纺织科学研究院Polyester-polyamide copolymer fiber and manufacturing method thereof
US20160347908A1 (en)*2013-12-132016-12-01Basf SeProcess for producing nylon-6,6
CN103757739A (en)*2013-12-312014-04-30马海燕Biodegradable polymer monofilament and production method thereof
CN105418918B (en)*2015-12-072017-09-19中北大学 High temperature resistant polyamide and its synthesis method
CN105646876B (en)2016-04-082018-06-19南京工业大学Method for preparing polyesteramide through organic catalysis
CN108102090A (en)*2016-11-242018-06-01上海杰事杰新材料(集团)股份有限公司Ultra-toughness heat-stabilised poly amide resin and preparation method thereof
CN108102091A (en)*2016-11-252018-06-01上海杰事杰新材料(集团)股份有限公司Biodegradable polyamide and preparation method thereof
CN108264637A (en)*2016-12-302018-07-10上海杰事杰新材料(集团)股份有限公司A kind of high-molecular-weight poly ester amide resin based on 1,2- propylene glycol and preparation method thereof
CN107383368B (en)*2017-08-182019-10-01浙江心源科技有限公司It is a kind of containing amide groups polyester polyol and in the application prepared on polyurethane
CN109957108B (en)*2017-12-252022-08-19上海凯赛生物技术股份有限公司Polyesteramide hot melt adhesive and preparation method thereof
CN109957107B (en)*2017-12-252022-07-19上海凯赛生物技术股份有限公司Polyesteramide and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
JPS54119594A (en)*1978-03-091979-09-17Agency Of Ind Science & TechnolBiodegradable film
US5446109A (en)*1993-02-231995-08-29Teijin LimitedPolyamide/aliphatic polyester block copolymer, process for the production thereof, and blend containing the same
JPH0710988A (en)*1993-06-241995-01-13Agency Of Ind Science & TechnolProduction of biodegradable polyester amide copolymer
DE4444948C2 (en)*1994-12-162000-02-24Inventa Ag Semi-crystalline block copolyester polyamides and use

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* Cited by examiner, † Cited by third party
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US10130591B2 (en)2003-08-062018-11-20Grünenthal GmbHAbuse-proofed dosage form
US8420056B2 (en)2003-08-062013-04-16Grunenthal GmbhAbuse-proofed dosage form
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US11224576B2 (en)2003-12-242022-01-18Grünenthal GmbHProcess for the production of an abuse-proofed dosage form
US8323889B2 (en)2004-07-012012-12-04Gruenenthal GmbhProcess for the production of an abuse-proofed solid dosage form
US11844865B2 (en)2004-07-012023-12-19Grünenthal GmbHAbuse-proofed oral dosage form
US8114384B2 (en)2004-07-012012-02-14Gruenenthal GmbhProcess for the production of an abuse-proofed solid dosage form
US10729658B2 (en)2005-02-042020-08-04Grünenthal GmbHProcess for the production of an abuse-proofed dosage form
US10675278B2 (en)2005-02-042020-06-09Grünenthal GmbHCrush resistant delayed-release dosage forms
US8080617B2 (en)2005-06-162011-12-20Dow Global Technologies LlcAliphatic polyester-amide compositions and a process for producing the same
US8722086B2 (en)2007-03-072014-05-13Gruenenthal GmbhDosage form with impeded abuse
US8383152B2 (en)2008-01-252013-02-26Gruenenthal GmbhPharmaceutical dosage form
US9750701B2 (en)2008-01-252017-09-05Grünenthal GmbHPharmaceutical dosage form
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US10080721B2 (en)2009-07-222018-09-25Gruenenthal GmbhHot-melt extruded pharmaceutical dosage form
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WO2019147457A2 (en)2018-01-232019-08-01Eastman Chemical CompanyNovel polyestermides, processes for the preparation thereof, and polyesteramide compositions
US11242456B2 (en)2018-01-232022-02-08Solutia Inc.Interlayers comprising polyesteramide compositions
US11578207B2 (en)2018-01-232023-02-14Solutia Inc.Interlayers comprising polyesteramide compositions
US11767429B2 (en)2018-01-232023-09-26Eastman Chemical CompanyPolyesteramides, processes for the preparation thereof, and polyesteramide compositions
WO2019147458A1 (en)2018-01-232019-08-01Eastman Chemical CompanyNovel polyesteramides, processes for the preparation thereof, and polyesteramide compositions
US11845864B2 (en)2018-01-232023-12-19Solutia Inc.Interlayers comprising polyesteramide compositions
WO2023023446A1 (en)2021-08-192023-02-23Solutia Inc.High molecular weight polyesteramides

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CN1285853A (en)2001-02-28
WO1999035179A1 (en)1999-07-15
KR20010033975A (en)2001-04-25
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DE19800698A1 (en)1999-07-15
AU2417599A (en)1999-07-26

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