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CA2149048A1 - Facteurs de croissance apparentes a l'insuline modifies - Google Patents

Facteurs de croissance apparentes a l'insuline modifies

Info

Publication number
CA2149048A1
CA2149048A1CA002149048ACA2149048ACA2149048A1CA 2149048 A1CA2149048 A1CA 2149048A1CA 002149048 ACA002149048 ACA 002149048ACA 2149048 ACA2149048 ACA 2149048ACA 2149048 A1CA2149048 A1CA 2149048A1
Authority
CA
Canada
Prior art keywords
igf
peg
mutein
conjugate
free cysteine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002149048A
Other languages
English (en)
Inventor
George N. Cox
Martin J. Mcdermott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Boulder Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IndividualfiledCriticalIndividual
Publication of CA2149048A1publicationCriticalpatent/CA2149048A1/fr
Abandonedlegal-statusCriticalCurrent

Links

Classifications

Landscapes

CA002149048A1992-11-251993-11-24Facteurs de croissance apparentes a l'insuline modifiesAbandonedCA2149048A1 (fr)

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
US98051992A1992-11-251992-11-25
US07/980,5191992-11-25

Publications (1)

Publication NumberPublication Date
CA2149048A1true CA2149048A1 (fr)1994-06-09

Family

ID=25527621

Family Applications (1)

Application NumberTitlePriority DateFiling Date
CA002149048AAbandonedCA2149048A1 (fr)1992-11-251993-11-24Facteurs de croissance apparentes a l'insuline modifies

Country Status (6)

CountryLink
EP (1)EP0679095A1 (fr)
JP (1)JPH08506095A (fr)
KR (1)KR950703999A (fr)
AU (1)AU6048294A (fr)
CA (1)CA2149048A1 (fr)
WO (1)WO1994012219A2 (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US5166322A (en)*1989-04-211992-11-24Genetics InstituteCysteine added variants of interleukin-3 and chemical modifications thereof
WO1995032003A1 (fr)*1994-05-241995-11-30Amgen Boulder Inc.Facteurs de croissance proches de l'insuline modifies
US5824784A (en)1994-10-121998-10-20Amgen Inc.N-terminally chemically modified protein compositions and methods
US7122636B1 (en)1997-02-212006-10-17Genentech, Inc.Antibody fragment-polymer conjugates and uses of same
US6870033B1 (en)1997-02-212005-03-22Genentech, Inc.Antibody fragment-polymer conjugates and humanized anti-IL-8 monoclonal antibodies
US7270809B2 (en)1997-07-142007-09-18Bolder Biotechnology, Inc.Cysteine variants of alpha interferon-2
US7495087B2 (en)1997-07-142009-02-24Bolder Biotechnology, Inc.Cysteine muteins in the C-D loop of human interleukin-11
US6753165B1 (en)1999-01-142004-06-22Bolder Biotechnology, Inc.Methods for making proteins containing free cysteine residues
WO1999003887A1 (fr)1997-07-141999-01-28Bolder Biotechnology, Inc.Derives d'hormone de croissance et proteines associees
US7153943B2 (en)1997-07-142006-12-26Bolder Biotechnology, Inc.Derivatives of growth hormone and related proteins, and methods of use thereof
US20080076706A1 (en)1997-07-142008-03-27Bolder Biotechnology, Inc.Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
US6468532B1 (en)1998-01-222002-10-22Genentech, Inc.Methods of treating inflammatory diseases with anti-IL-8 antibody fragment-polymer conjugates
US7005504B2 (en)1998-01-222006-02-28Genentech, Inc.Antibody fragment-peg conjugates
US6458355B1 (en)1998-01-222002-10-01Genentech, Inc.Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates
WO1999051262A2 (fr)1998-04-031999-10-14Chiron CorporationUtilisation d'igf1 pour traiter des maladies du cartilage articulaire
BR0008759B1 (pt)*1999-01-142014-03-11Bolder Biotechnology IncMétodos para a produção de proteinas contendo resíduos de cisteina livre
US8288126B2 (en)1999-01-142012-10-16Bolder Biotechnology, Inc.Methods for making proteins containing free cysteine residues
ATE303400T1 (de)1999-04-022005-09-15Ajinomoto KkVefahren zur herstellung von peptiduntereinheiten aus polymer-proteinen
US6309633B1 (en)*1999-06-192001-10-30Nobex CorporationAmphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
JP4873818B2 (ja)2000-05-162012-02-08ボルダー バイオテクノロジー, インコーポレイテッド遊離システイン残基を含有するタンパク質をリフォールディングする方法
US20040186051A1 (en)2001-10-022004-09-23Kelley Robert FApo-2 ligand variants and uses thereof
JP4574350B2 (ja)2002-06-242010-11-04ジェネンテック, インコーポレイテッドApo−2リガンド/trail変異体とその使用法
US20060228331A1 (en)2003-10-102006-10-12Novo Nordisk A/SIL-21 Derivatives and variants
EP1674113A1 (fr)*2004-12-222006-06-28F. Hoffmann-La Roche AgConjugués de l'IGF-1 et du poly(éthylène glycol)
WO2006134173A2 (fr)*2005-06-172006-12-21Novo Nordisk Health Care AgReduction et derivation selectives de proteines conçues par le genie genetique comprenant au moins une cysteine non native
WO2007041614A2 (fr)2005-10-032007-04-12Bolder Biotechnology, Inc.Inhibiteurs de vegf a action prolongee et leurs methodes d'utilisation
CL2007002502A1 (es)2006-08-312008-05-30Hoffmann La RocheVariantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer.
ES2393373T3 (es)2006-08-312012-12-20F. Hoffmann-La Roche AgMétodo para la producción de factor-I de crecimiento similar a la insulina
CA2666426A1 (fr)2006-10-262008-05-02Novo Nordisk A/SVariantes il-21
EP2102355B1 (fr)2006-12-142016-03-02Bolder Biotechnology, Inc.Protéines et peptides à action prolongée et procédés de production et d'utilisation de ces derniers
RU2584572C2 (ru)*2010-02-112016-05-20Ф.Хоффманн-Ля Рош АгСпособ получения полипептида, конъюгированного с поли(этиленгликолевым) фрагментом, нуклеиновая кислота и слитый полипептид, предназначенные для применения в способе
BR112016002845A2 (pt)2013-08-122017-09-12Genentech Inccomposições e métodos para tratar condições associadas ao complemento
BR112016025312A2 (pt)2014-05-012017-10-17Genentech Incvariantes de anticorpo, anticorpo anti-fator d, formulação farmacêutica, dispositivo de distribuição, utilização da formulação e de uma composição, composição e método de tratamento de uma desordem
JP2018536650A (ja)2015-10-302018-12-13ジェネンテック, インコーポレイテッド抗d因子抗体変異体コンジュゲート及びその使用
EP3368074A2 (fr)2015-10-302018-09-05Hoffmann-La Roche AGAnticorps et conjugués anti-facteur d
JP2023519213A (ja)2020-03-242023-05-10ジェネンテック, インコーポレイテッドTie2結合剤および使用方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US5206344A (en)*1985-06-261993-04-27Cetus Oncology CorporationInterleukin-2 muteins and polymer conjugation thereof
DE69128944T2 (de)*1990-05-041998-06-25American Cyanamid CoStabilisierung von Somatotropin durch Modifizierung von Cysteinsresten

Also Published As

Publication numberPublication date
WO1994012219A3 (fr)1994-07-21
EP0679095A1 (fr)1995-11-02
KR950703999A (ko)1995-11-17
AU6048294A (en)1994-06-22
JPH08506095A (ja)1996-07-02
WO1994012219A2 (fr)1994-06-09

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