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CA2086914A1 - Quinolone-and naphthyridone-carboxylic acid derivatives - Google Patents

Quinolone-and naphthyridone-carboxylic acid derivatives

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Publication number
CA2086914A1
CA2086914A1CA002086914ACA2086914ACA2086914A1CA 2086914 A1CA2086914 A1CA 2086914A1CA 002086914 ACA002086914 ACA 002086914ACA 2086914 ACA2086914 ACA 2086914ACA 2086914 A1CA2086914 A1CA 2086914A1
Authority
CA
Canada
Prior art keywords
carboxylic acid
acid derivatives
naphthyridone
quinolone
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002086914A
Other languages
French (fr)
Other versions
CA2086914C (en
Inventor
Uwe Petersen
Andreas Krebs
Thomas Schenke
Thomas Philipps
Klaus Grohe
Klaus-Dieter Bremm
Rainer Endermann
Karl-Georg Metzger
Ingo Haller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filedlitigationCriticalhttps://patents.darts-ip.com/?family=27203290&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2086914(A1)"Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE4200414Aexternal-prioritypatent/DE4200414A1/en
Priority claimed from DE4208789Aexternal-prioritypatent/DE4208789A1/en
Priority claimed from DE4208792Aexternal-prioritypatent/DE4208792A1/en
Application filed by Bayer AGfiledCriticalBayer AG
Priority to CA002443307ApriorityCriticalpatent/CA2443307C/en
Publication of CA2086914A1publicationCriticalpatent/CA2086914A1/en
Application grantedgrantedCritical
Publication of CA2086914CpublicationCriticalpatent/CA2086914C/en
Anticipated expirationlegal-statusCritical
Expired - Lifetimelegal-statusCriticalCurrent

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Abstract

The invention relates to new quinolone- and naphthyridone carboxylic acid derivatives, processes for their preparation and also antibacterial agents and feed additives containing them.
CA002086914A1992-01-101993-01-07Quinolone-and naphthyridone-carboxylic acid derivativesExpired - LifetimeCA2086914C (en)

Priority Applications (1)

Application NumberPriority DateFiling DateTitle
CA002443307ACA2443307C (en)1992-01-101993-01-07Quinolone- and naphthyridone-carboxylic acid derivatives

Applications Claiming Priority (6)

Application NumberPriority DateFiling DateTitle
DEP4200414.41992-01-10
DE4200414ADE4200414A1 (en)1992-01-101992-01-10New quinoline and naphthyridinone-carboxylic acid derivs.
DE4208789ADE4208789A1 (en)1992-03-191992-03-19New quinoline and naphthyridinone-carboxylic acid derivs.
DE4208792ADE4208792A1 (en)1992-03-191992-03-19New quinoline and naphthyridinone-carboxylic acid derivs.
DEP4208792.91992-03-19
DEP4208789.91992-03-19

Related Child Applications (1)

Application NumberTitlePriority DateFiling Date
CA002443307ADivisionCA2443307C (en)1992-01-101993-01-07Quinolone- and naphthyridone-carboxylic acid derivatives

Publications (2)

Publication NumberPublication Date
CA2086914A1true CA2086914A1 (en)1993-07-11
CA2086914C CA2086914C (en)2005-03-15

Family

ID=27203290

Family Applications (1)

Application NumberTitlePriority DateFiling Date
CA002086914AExpired - LifetimeCA2086914C (en)1992-01-101993-01-07Quinolone-and naphthyridone-carboxylic acid derivatives

Country Status (16)

CountryLink
EP (1)EP0550903A1 (en)
JP (3)JPH05271229A (en)
KR (1)KR100251886B1 (en)
CN (3)CN1043142C (en)
AU (1)AU669502B2 (en)
CA (1)CA2086914C (en)
CZ (1)CZ289076B6 (en)
FI (3)FI104174B (en)
HU (1)HU219488B (en)
MX (1)MX9207604A (en)
MY (1)MY115416A (en)
NO (1)NO301420B1 (en)
NZ (1)NZ245640A (en)
PL (1)PL174853B1 (en)
SK (3)SK285155B6 (en)
TW (1)TW209865B (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US6392044B1 (en)1999-07-062002-05-21Bayer AktiengesellschaftRacemization of R,S-dioxo-benzylpyrrolopiperidine
US6395746B1 (en)1998-09-302002-05-28Alcon Manufacturing, Ltd.Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
US6509327B1 (en)1998-09-302003-01-21Alcon Manufacturing, Ltd.Compositions and methods for treating otic, ophthalmic and nasal infections
US6566523B1 (en)1999-06-162003-05-20Bayer AktiengesellschaftMethod for the enantiomer separation of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane
US6716830B2 (en)1998-09-302004-04-06Alcon, Inc.Ophthalmic antibiotic compositions containing moxifloxacin
US6897315B2 (en)1997-11-242005-05-24Bayer Healthcare AktiengesellschaftMethod for producing 8-methoxy-quinolinecarboxylic acids
US7759362B2 (en)2004-04-212010-07-20Institut Of Medicinal Biotechnology Chinese Academy Of Medical SciencesQuinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
US8975275B2 (en)1999-12-222015-03-10Bayer Innovation GmbhUse of chemotherapeutic agents

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DE4121214A1 (en)*1991-06-271993-01-14Bayer Ag 7-AZAISOINDOLINYL CHINOLONE AND NAPHTHYRIDONE CARBONIC ACID DERIVATIVES
JP3268098B2 (en)*1992-12-252002-03-25第一製薬株式会社 Bicyclic cyclic amine derivative
KR0148277B1 (en)*1993-01-181998-11-02채영복Novel fluoroquinolone derivatives and process for the preparation thereof
DE4301246A1 (en)*1993-01-191994-07-21Bayer Ag Quinolone and naphthyridonecarboxylic acid derivatives
JP3372994B2 (en)1993-06-112003-02-04富士写真フイルム株式会社 Processing method of silver halide color photographic light-sensitive material
DE4329600A1 (en)*1993-09-021995-03-09Bayer Ag Pyrido [1,2,3-d, e] [1,3,4] benzoxadiazine derivatives
KR950018003A (en)*1993-12-091995-07-22스미스클라인 비참 피엘씨 Novel quinolone derivatives and methods for their preparation
DE4342186A1 (en)*1993-12-101995-06-14Bayer Ag One-pot process for the production of 3-quinolonecarboxylic acid derivatives
DE4418510A1 (en)*1994-05-271995-11-30Bayer Ag 1,9-bridged thiazolol [3,4-a] quinoline derivatives
WO1996040981A1 (en)*1995-06-071996-12-19Bayer AktiengesellschaftTesting device for determining the susceptibility of microorganisms to inhibitory agents
DE19546249A1 (en)1995-12-121997-06-19Bayer Ag New crystal modification of 1-cyclopropyl-7 - ([S, S] -2,8-diazabicyclo [4,3,0] non-8-yl) -6-fluoro-1,4-dihydro-8-methoxy-4 -oxo-3-quinoline carboxylic acid hydrochloride (CDCH), process for its preparation and pharmaceutical preparations containing it
DE19652239A1 (en)*1996-12-161998-06-18Bayer Ag Use of 7- (2-oxa-5,8-diazabicyclo [4.3.0] non-8-yl) -quinolone and naphthyridonecarboxylic acid derivatives for the therapy of Helicobacter pylori infections and the associated gastroduodenal diseases
DE19735198A1 (en)*1997-08-141999-02-18Bayer AgOptical resolution of cis- or trans-pyrrolo:piperidine derivatives
PT1017392E (en)*1997-09-252002-10-31Bayer Ag FORMULATION OF MEDICINAL PRODUCTS WITH CONTROLLED LIBERATION OF THE ACTIVE SUBSTANCE
DE19821039A1 (en)*1998-05-111999-11-18Bayer AgProduction of (S,S)-8-benzyl-2,8-diazabicyclo(4.3.0)nonane useful as intermediate for antibiotic moxifloxacin
AR020661A1 (en)*1998-09-302002-05-22Alcon Lab Inc A PHARMACEUTICAL COMPOSITION TOPICA OFTALMICA, OTICA OR NASAL AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
ID29089A (en)*1998-11-102001-07-26Bayer Ag MOKSIFLOXASIN PHARMACEUTICAL PROPERTIES
JP4694669B2 (en)1999-03-172011-06-08第一三共株式会社 Pharmaceutical composition
DE10226923A1 (en)2002-06-172003-12-24Bayer Ag Process for the enantiomer enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo [4.3.0] nonane
ITMI20032259A1 (en)*2003-11-202005-05-21Chemi Spa NEW POLYMORPHOUS OF ACID 1-CYCLOPROPYL-7- (S, S-2,8-DIAZABICLO-4.3.0-NON-8-IL) -6-FLUORO-1,4-DIIDRO-8-METOSSI-4-OXO -CHINOLIN CARBOSXYL CHLORIDRATE AND METHODS FOR ITS PREPARATION
ES2319125T3 (en)*2003-11-202009-05-04Chemi S.P.A. POLYMORPHES OF ACID CHLORHYDRATE 1-CICLOPROPIL-7 - ((S, S) -2,8-DIAZADICICLO (4.3.0) -NON-8-IL) -6-FLUORO-1,4-DIHYDRO-8-METOXI- 4-OXO-3-CARBOXYLIN CHINOLINE AND METHODS FOR THE PREPARATION OF THE SAME.
CN1244582C (en)*2004-04-212006-03-08中国医学科学院医药生物技术研究所 Quinolone carboxylic acid compound and its preparation method and medical application
ES2284380B1 (en)*2006-03-102008-11-01Quimica Sintetica S.A. PROCEDURE FOR THE PREPARATION OF MOXIFLOXACINO AND MOXIFLOXACINO CHLORHYDRATE.
WO2008000418A2 (en)2006-06-272008-01-03Sandoz AgNew method for salt preparation
IN2014MN02582A (en)2006-11-132015-09-11Cipla Ltd
WO2008059521A2 (en)*2006-11-142008-05-22Msn Laboratories LimitedNovel process for the preparation of moxifloxacin hydrochloride and a novel polymorph of moxifloxacin
US7692015B2 (en)2007-01-052010-04-06Zheqing WangEconomical process for preparing (S, S)-2, 8-diazabicyclo[4.3.0]nonane and its enantiomer
WO2008102188A1 (en)2007-02-222008-08-28Tibor NagyProcedure to manufacture and use beer and other types liquids treated with neodimium magnet
EP2083010A1 (en)2008-01-082009-07-29Chemo Ibérica, S.A.Polymorphic Forms of Moxifloxacin hydrochloride and processes for preparation thereof
EP2154137A1 (en)2008-08-042010-02-17Chemo Ibérica, S.A.Crystalline form of moxifloxacin base
IT1393337B1 (en)2009-03-062012-04-20Italiana Sint Spa SUMMARY OF (4AS, 7AS) -OTTAIDRO-1H-PIRROLO [3,4-B] PYRIDINE
WO2010122774A1 (en)*2009-04-202010-10-28株式会社カネカProcesses for producing (1s,6s)- or (1r,6r)-cis-2,8-diazabicyclo[4.3.0]nonane and intermediate thereof
IT1398952B1 (en)*2010-03-192013-03-28F S I Fabbrica Italiana Sint PROCESS OF PREPARATION OF MOXIFLOXACINE AND ITS SALTS
CN101941969B (en)*2010-09-302012-05-23江苏正大丰海制药有限公司Preparation method of moxifloxacin hydrochloride
CN102675308A (en)*2011-03-172012-09-19苏州中科天马肽工程中心有限公司Method for preparing 8-benzyl-2,8-diazabicyclo(4.3.0) nonane
CN102675307A (en)*2011-03-172012-09-19苏州中科天马肽工程中心有限公司Method for preparing chiral compound 8-phenethyl-2,8-diazabicyclo[4.3.0]nonane
ITTO20110705A1 (en)2011-07-292013-01-30Italiana Sint Spa PROCEDURE FOR THE PREPARATION OF MOXIFLOXACINE CHLORIDRATE AND RELATED INTERMEDIATES
CN102964346B (en)*2011-09-012015-04-22中国中化股份有限公司Preparation method of (S, S)-octahydro-6H-pyrrolo[3, 4-b]pyridine
CN103044418B (en)*2011-10-142015-02-04上海朴颐化学科技有限公司Asymmetric synthesis method, relevant raw materials and preparation method of (S,S)-2,8-diazabicyclo[4,3,0] nonane
CN102408427B (en)*2011-10-222012-12-12浙江普洛康裕制药有限公司Preparation method for moxifloxacin intermediate (1S, 6R)-8-benzyl-7, 9-dioxy-2, 8-diazabicyclo [4.3.0] nonane
BRPI1106900A2 (en)2011-12-262013-11-05Ems Sa SOLID PHARMACEUTICAL COMPOSITION UNDERSTANDING ANTIBOTH FAMILY OF QUINOLONES AND THE PROCESS OF OBTAINING THEM
FR2992218B1 (en)2012-06-222015-01-23Rivopharm Sa PHARMACEUTICAL COMPOSITION OF MOXIFLOXACIN HYDROCHLORIDE AND PROCESS FOR PREPARING THE SAME
EP2928892B1 (en)2012-12-042018-03-21Mankind Pharma Ltd.An improved process for the preparation of moxifloxacin hydrochloride
CN103012452B (en)*2012-12-252015-12-02浙江新和成股份有限公司The preparation method of a kind of Moxifloxacin and hydrochloride thereof
UA106556C2 (en)*2013-05-132014-09-10Наталья Николаевна ДеркачMethod of obtaining (1-cyclopropyl -6- fluoro-1,4-dihydro methoxy -8 -7 - [(4as, 7as) - oktahydro -6n- pyrrolo [3,4-pyridine bsch - 6- yl] -4-oxo-3-hinolinkarbonovoyi acid
CN103724262B (en)*2013-12-102016-05-18广东省第二人民医院A kind of fluoquinolone silver compound and its production and use
CN104860944A (en)*2015-06-092015-08-26内蒙古东北六药集团有限公司Production method of moxifloxacin hydrochloride
CN108872413B (en)*2018-04-272021-06-08山东齐都药业有限公司 Method for the determination of enantiomeric content in (S,S)-2,8-diazabicyclo[4,3,0]nonane
CN110627768B (en)*2018-06-222021-11-09扬子江药业集团有限公司Preparation method of moxifloxacin degradation impurity J
CN110183445B (en)*2019-06-282021-08-24昆明学院 Synthetic method of moxifloxacin and its derivatives
RU2713932C1 (en)*2019-10-312020-02-11федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ)Fluoroquinolone compounds based on pyridoxine derivatives, having antibacterial properties
CN112939849B (en)*2019-12-112022-05-03浙江新和成股份有限公司(S, S) -2, 8-diazabicyclo [4.3.0] nonane intermediate and preparation method and application thereof
CN110981874A (en)*2020-03-052020-04-10北京四环生物制药有限公司Preparation method of moxifloxacin hydrochloride
CN112409352B (en)*2020-11-202022-05-24华南理工大学Moxifloxacin drug derivatives and preparation method and application thereof
CN112574197B (en)*2020-12-072021-12-31泰安汉威集团有限公司Chiral purification method of compound C

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DE3906365A1 (en)*1988-07-151990-01-18Bayer Ag 7- (1-PYRROLIDINYL) -3-CHINOLONE AND NAPHTHYRIDONE CARBOXYLIC ACID DERIVATIVES, METHOD AND SUBSTITUTED (OXA) DIAZABICYCLOOCTANES AND NONANESE AS INTERMEDIATE PRODUCTS, AND ANTIBACTERIAL AGENTS AND FOOD ADDITIVES CONTAINING THEM
AU5123690A (en)*1989-03-131990-09-13Bristol-Myers Squibb Company5-substituted-1,4-dihydro-4-oxo-nephthyridine-3-carboxylate antibacterial agents
DE3910663A1 (en)*1989-04-031990-10-04Bayer Ag 5-ALKYLCHINOLON CARBONIC ACIDS
JPH03188080A (en)*1989-12-151991-08-16Banyu Pharmaceut Co LtdPyridonecarboxylic acid derivative

Cited By (12)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US6897315B2 (en)1997-11-242005-05-24Bayer Healthcare AktiengesellschaftMethod for producing 8-methoxy-quinolinecarboxylic acids
US7115744B2 (en)1997-11-242006-10-03Bayer Healthcare AktiengesellschaftMethod for producing 8-methoxy-quinolinecarboxylic acids
US6395746B1 (en)1998-09-302002-05-28Alcon Manufacturing, Ltd.Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
US6509327B1 (en)1998-09-302003-01-21Alcon Manufacturing, Ltd.Compositions and methods for treating otic, ophthalmic and nasal infections
US6716830B2 (en)1998-09-302004-04-06Alcon, Inc.Ophthalmic antibiotic compositions containing moxifloxacin
US7671070B2 (en)1998-09-302010-03-02Alcon, Inc.Method of treating ophthalmic infections with moxifloxacin compositions
US8673902B2 (en)1998-09-302014-03-18Alcon Pharmaceuticals, Ltd.Method of treating otic infections with moxifloxacin compositions
US8993636B2 (en)1998-09-302015-03-31Alcon Pharamceuticals, Ltd.Compositions containing moxifloxacin for treating otic infections
US6566523B1 (en)1999-06-162003-05-20Bayer AktiengesellschaftMethod for the enantiomer separation of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane
US6392044B1 (en)1999-07-062002-05-21Bayer AktiengesellschaftRacemization of R,S-dioxo-benzylpyrrolopiperidine
US8975275B2 (en)1999-12-222015-03-10Bayer Innovation GmbhUse of chemotherapeutic agents
US7759362B2 (en)2004-04-212010-07-20Institut Of Medicinal Biotechnology Chinese Academy Of Medical SciencesQuinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof

Also Published As

Publication numberPublication date
MY115416A (en)2003-06-30
MX9207604A (en)1993-10-01
PL174853B1 (en)1998-09-30
AU3105493A (en)1993-07-15
CN1043142C (en)1999-04-28
AU669502B2 (en)1996-06-13
TW209865B (en)1993-07-21
SK2232000A3 (en)2006-05-04
FI113771B (en)2004-06-15
NO924978D0 (en)1992-12-22
JP4111431B2 (en)2008-07-02
NO924978L (en)1993-07-12
NZ245640A (en)1995-03-28
FI104174B1 (en)1999-11-30
CN1074218A (en)1993-07-14
SK396692A3 (en)2002-09-10
SK285155B6 (en)2006-07-07
SK2212000A3 (en)2006-05-04
FI930049A (en)1993-07-11
CZ396692A3 (en)1993-08-11
FI990207A0 (en)1999-02-03
JP2003026574A (en)2003-01-29
KR930016421A (en)1993-08-26
EP0550903A1 (en)1993-07-14
CN1192440A (en)1998-09-09
SK282971B6 (en)2003-01-09
FI990207L (en)1999-02-03
JPH05271229A (en)1993-10-19
FI20020059L (en)2002-01-11
CN1212256A (en)1999-03-31
CA2086914C (en)2005-03-15
JP2003048890A (en)2003-02-21
KR100251886B1 (en)2000-07-01
FI104174B (en)1999-11-30
NO301420B1 (en)1997-10-27
CZ289076B6 (en)2001-10-17
HU9300034D0 (en)1993-04-28
HUT64065A (en)1993-11-29
SK285223B6 (en)2006-09-07
FI930049A0 (en)1993-01-07
CN1075499C (en)2001-11-28
HU219488B (en)2001-04-28
FI110943B (en)2003-04-30
PL297338A1 (en)1993-09-06
CN1061351C (en)2001-01-31

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