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CA2024855A1 - Process and intermediates for producing glucagon - Google Patents

Process and intermediates for producing glucagon

Info

Publication number
CA2024855A1
CA2024855A1CA 2024855CA2024855ACA2024855A1CA 2024855 A1CA2024855 A1CA 2024855A1CA 2024855CA2024855CA 2024855CA 2024855 ACA2024855 ACA 2024855ACA 2024855 A1CA2024855 A1CA 2024855A1
Authority
CA
Canada
Prior art keywords
glucagon
intermediates
producing glucagon
fragments
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2024855
Other languages
French (fr)
Other versions
CA2024855C (en
Inventor
Jean-Andre Gauthier
Nedumparambil A. Abraham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Canada Ltd
Original Assignee
Bio Mega Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega IncfiledCriticalBio Mega Inc
Priority to CA 2024855priorityCriticalpatent/CA2024855C/en
Publication of CA2024855A1publicationCriticalpatent/CA2024855A1/en
Application grantedgrantedCritical
Publication of CA2024855CpublicationCriticalpatent/CA2024855C/en
Anticipated expirationlegal-statusCritical
Expired - Fee Relatedlegal-statusCriticalCurrent

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Abstract

Disclosed herein is an improved process for preparing the nonacosapeptide glucagon. The process comprises the serial coupling of two highly purified fragments, glucagon(15-22) and glucagon(7-14) fragments, to a modified glucagon(23-29) fragment having a benzhydrylamine type resin attached to the .omega.-carboxyl of Asp at position 28.
CA 20248551990-09-071990-09-07Process and intermediates for producing glucagonExpired - Fee RelatedCA2024855C (en)

Priority Applications (1)

Application NumberPriority DateFiling DateTitle
CA 2024855CA2024855C (en)1990-09-071990-09-07Process and intermediates for producing glucagon

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
CA 2024855CA2024855C (en)1990-09-071990-09-07Process and intermediates for producing glucagon

Publications (2)

Publication NumberPublication Date
CA2024855A1true CA2024855A1 (en)1992-03-08
CA2024855C CA2024855C (en)1997-12-09

Family

ID=4145922

Family Applications (1)

Application NumberTitlePriority DateFiling Date
CA 2024855Expired - Fee RelatedCA2024855C (en)1990-09-071990-09-07Process and intermediates for producing glucagon

Country Status (1)

CountryLink
CA (1)CA2024855C (en)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US8338368B2 (en)2005-11-072012-12-25Indiana University Research And Technology CorporationGlucagon analogs exhibiting physiological solubility and stability
US8450270B2 (en)2008-06-172013-05-28Indiana University Research And Technology CorporationGlucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers
US8454971B2 (en)2007-02-152013-06-04Indiana University Research And Technology CorporationGlucagon/GLP-1 receptor co-agonists
US8507428B2 (en)2010-12-222013-08-13Indiana University Research And Technology CorporationGlucagon analogs exhibiting GIP receptor activity
US8546327B2 (en)2008-06-172013-10-01Indiana University Research And Technology CorporationGlucagon/GLP-1 receptor co-agonists
US8551946B2 (en)2010-01-272013-10-08Indiana University Research And Technology CorporationGlucagon antagonist-GIP agonist conjugates and compositions for the treatment of metabolic disorders and obesity
US8669228B2 (en)2007-01-052014-03-11Indiana University Research And Technology CorporationGlucagon analogs exhibiting enhanced solubility in physiological pH buffers
US8703701B2 (en)2009-12-182014-04-22Indiana University Research And Technology CorporationGlucagon/GLP-1 receptor co-agonists
US8729017B2 (en)2011-06-222014-05-20Indiana University Research And Technology CorporationGlucagon/GLP-1 receptor co-agonists
US8778872B2 (en)2010-06-242014-07-15Indiana University Research And Technology CorporationAmide based glucagon superfamily peptide prodrugs
US8859491B2 (en)2011-11-172014-10-14Indiana University Research And Technology CorporationGlucagon superfamily peptides exhibiting glucocorticoid receptor activity
US8969288B2 (en)2008-12-192015-03-03Indiana University Research And Technology CorporationAmide based glucagon and superfamily peptide prodrugs
US8980830B2 (en)2007-10-302015-03-17Indiana University Research And Technology CorporationPeptide compounds exhibiting glucagon antagonist and GLP-1 agonist activity
US8981047B2 (en)2007-10-302015-03-17Indiana University Research And Technology CorporationGlucagon antagonists
US9062124B2 (en)2008-06-172015-06-23Indiana University Research And Technology CorporationGIP-based mixed agonists for treatment of metabolic disorders and obesity
US9127088B2 (en)2010-05-132015-09-08Indiana University Research And Technology CorporationGlucagon superfamily peptides exhibiting nuclear hormone receptor activity
US9145451B2 (en)2010-05-132015-09-29Indiana University Research And Technology CorporationGlucagon superfamily peptides exhbiting G protein coupled receptor activity
US9150632B2 (en)2009-06-162015-10-06Indiana University Research And Technology CorporationGIP receptor-active glucagon compounds
US9156902B2 (en)2011-06-222015-10-13Indiana University Research And Technology CorporationGlucagon/GLP-1 receptor co-agonists
US9340600B2 (en)2012-06-212016-05-17Indiana University Research And Technology CorporationGlucagon analogs exhibiting GIP receptor activity

Cited By (31)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US9018164B2 (en)2005-11-072015-04-28Indiana University Research And Technology CorporationGlucagon analogs exhibiting physiological solubility and stability
US8338368B2 (en)2005-11-072012-12-25Indiana University Research And Technology CorporationGlucagon analogs exhibiting physiological solubility and stability
US8669228B2 (en)2007-01-052014-03-11Indiana University Research And Technology CorporationGlucagon analogs exhibiting enhanced solubility in physiological pH buffers
US8454971B2 (en)2007-02-152013-06-04Indiana University Research And Technology CorporationGlucagon/GLP-1 receptor co-agonists
US8900593B2 (en)2007-02-152014-12-02Indiana University Research And Technology CorporationGlucagon/GLP-1 receptor co-agonists
US9447162B2 (en)2007-02-152016-09-20Indiana University Research And Technology CorporationGlucagon/GLP-1 receptor co-agonists
US8981047B2 (en)2007-10-302015-03-17Indiana University Research And Technology CorporationGlucagon antagonists
US8980830B2 (en)2007-10-302015-03-17Indiana University Research And Technology CorporationPeptide compounds exhibiting glucagon antagonist and GLP-1 agonist activity
US9062124B2 (en)2008-06-172015-06-23Indiana University Research And Technology CorporationGIP-based mixed agonists for treatment of metabolic disorders and obesity
US8546327B2 (en)2008-06-172013-10-01Indiana University Research And Technology CorporationGlucagon/GLP-1 receptor co-agonists
US8450270B2 (en)2008-06-172013-05-28Indiana University Research And Technology CorporationGlucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers
US8969288B2 (en)2008-12-192015-03-03Indiana University Research And Technology CorporationAmide based glucagon and superfamily peptide prodrugs
US9150632B2 (en)2009-06-162015-10-06Indiana University Research And Technology CorporationGIP receptor-active glucagon compounds
US9790263B2 (en)2009-06-162017-10-17Indiana University Research And Technology CorporationGIP receptor-active glucagon compounds
US8703701B2 (en)2009-12-182014-04-22Indiana University Research And Technology CorporationGlucagon/GLP-1 receptor co-agonists
US8551946B2 (en)2010-01-272013-10-08Indiana University Research And Technology CorporationGlucagon antagonist-GIP agonist conjugates and compositions for the treatment of metabolic disorders and obesity
US9487571B2 (en)2010-01-272016-11-08Indiana University Research And Technology CorporationGlucagon antagonist-GIP agonist conjugates and compositions for the treatment of metabolic disorders and obesity
US9127088B2 (en)2010-05-132015-09-08Indiana University Research And Technology CorporationGlucagon superfamily peptides exhibiting nuclear hormone receptor activity
US9145451B2 (en)2010-05-132015-09-29Indiana University Research And Technology CorporationGlucagon superfamily peptides exhbiting G protein coupled receptor activity
US9783592B2 (en)2010-05-132017-10-10Indiana University Research And Technology CorporationGlucagon superfamily peptides exhibiting nuclear hormone receptor activity
US8778872B2 (en)2010-06-242014-07-15Indiana University Research And Technology CorporationAmide based glucagon superfamily peptide prodrugs
US8507428B2 (en)2010-12-222013-08-13Indiana University Research And Technology CorporationGlucagon analogs exhibiting GIP receptor activity
US9249206B2 (en)2010-12-222016-02-02Indiana University Research And Technology CorporationGlucagon analogs exhibiting GIP receptor activity
US8729017B2 (en)2011-06-222014-05-20Indiana University Research And Technology CorporationGlucagon/GLP-1 receptor co-agonists
US9309301B2 (en)2011-06-222016-04-12Indiana University Research And Technology CorporationGlucagon/GLP-1 receptor co-agonists
US9758562B2 (en)2011-06-222017-09-12Indiana University and Technology CorporationGlucagon/GLP-1 receptor co-agonists
US9156902B2 (en)2011-06-222015-10-13Indiana University Research And Technology CorporationGlucagon/GLP-1 receptor co-agonists
US10174093B2 (en)2011-06-222019-01-08Indiana University Research And Technology CorporationGlucagon/GLP-1 receptor co-agonists
US10730923B2 (en)2011-06-222020-08-04Indiana University Research And Technology CorporationGlucagon/GLP-1 receptor co-agonists
US8859491B2 (en)2011-11-172014-10-14Indiana University Research And Technology CorporationGlucagon superfamily peptides exhibiting glucocorticoid receptor activity
US9340600B2 (en)2012-06-212016-05-17Indiana University Research And Technology CorporationGlucagon analogs exhibiting GIP receptor activity

Also Published As

Publication numberPublication date
CA2024855C (en)1997-12-09

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