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CA2005502A1 - Somatotropin analogs - Google Patents

Somatotropin analogs

Info

Publication number
CA2005502A1
CA2005502A1CA 2005502CA2005502ACA2005502A1CA 2005502 A1CA2005502 A1CA 2005502A1CA 2005502CA2005502CA 2005502CA 2005502 ACA2005502 ACA 2005502ACA 2005502 A1CA2005502 A1CA 2005502A1
Authority
CA
Canada
Prior art keywords
analogs
somatotropin
somatotropin analogs
lactation
serine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2005502
Other languages
French (fr)
Other versions
CA2005502C (en
Inventor
Alan J. Parcells
John E. Mott
Che-Shen C. Tomich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn CofiledCriticalUpjohn Co
Publication of CA2005502A1publicationCriticalpatent/CA2005502A1/en
Application grantedgrantedCritical
Publication of CA2005502CpublicationCriticalpatent/CA2005502C/en
Anticipated expirationlegal-statusCritical
Expired - Fee Relatedlegal-statusCriticalCurrent

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Abstract

This invention provides mammalian somatotropin analogs, and in particular, bovine somatotropin analogs in which at least one of the cysteine amino acids at positions 53, 164, 181 or 189 has been replaced with serine. Also provided are methods for enhancing growth and lactation using such analogs.
CA 20055021989-01-311989-12-15Somatotropin analogsExpired - Fee RelatedCA2005502C (en)

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
US30473389A1989-01-311989-01-31
US07/304,7331989-01-31

Publications (2)

Publication NumberPublication Date
CA2005502A1true CA2005502A1 (en)1990-07-31
CA2005502C CA2005502C (en)2001-06-05

Family

ID=23177749

Family Applications (1)

Application NumberTitlePriority DateFiling Date
CA 2005502Expired - Fee RelatedCA2005502C (en)1989-01-311989-12-15Somatotropin analogs

Country Status (6)

CountryLink
EP (1)EP0456642A1 (en)
JP (1)JP3207416B2 (en)
AU (1)AU620673B2 (en)
CA (1)CA2005502C (en)
DK (1)DK140491D0 (en)
WO (1)WO1990008823A1 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
ATE198353T1 (en)*1988-08-242001-01-15American Cyanamid Co STABILIZATION OF SOMATOTROPINES THROUGH MODIFICATION OF CYSTEIN RESIDUE THROUGH SITE-SPECIFIC MUtagenesis OR CHEMICAL DERIVATIZATION
US5688666A (en)*1988-10-281997-11-18Genentech, Inc.Growth hormone variants with altered binding properties
US5534617A (en)*1988-10-281996-07-09Genentech, Inc.Human growth hormone variants having greater affinity for human growth hormone receptor at site 1
US5849694A (en)*1990-07-161998-12-15Synenki; Richard M.Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof
ES2190388T3 (en)*1995-09-212006-04-01Genentech, Inc. VARIANTS OF HUMAN GROWTH HORMONE.
US7214660B2 (en)2001-10-102007-05-08Neose Technologies, Inc.Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en)2001-10-102007-02-06Neose Technologies, Inc.Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7696163B2 (en)2001-10-102010-04-13Novo Nordisk A/SErythropoietin: remodeling and glycoconjugation of erythropoietin
US7795210B2 (en)2001-10-102010-09-14Novo Nordisk A/SProtein remodeling methods and proteins/peptides produced by the methods
US8008252B2 (en)2001-10-102011-08-30Novo Nordisk A/SFactor VII: remodeling and glycoconjugation of Factor VII
ES2420581T3 (en)2003-03-142013-08-26Biogenerix Gmbh Branched water soluble polymers and their conjugates
EP2338333B1 (en)2003-04-092017-09-06ratiopharm GmbHGlycopegylation methods and proteins/peptides produced by the methods
CA2524936A1 (en)2003-05-092004-12-02Neose Technologies, Inc.Compositions and methods for the preparation of human growth hormone glycosylation mutants
US9005625B2 (en)2003-07-252015-04-14Novo Nordisk A/SAntibody toxin conjugates
US8633157B2 (en)2003-11-242014-01-21Novo Nordisk A/SGlycopegylated erythropoietin
US20080305992A1 (en)2003-11-242008-12-11Neose Technologies, Inc.Glycopegylated erythropoietin
US7956032B2 (en)2003-12-032011-06-07Novo Nordisk A/SGlycopegylated granulocyte colony stimulating factor
ES2560657T3 (en)2004-01-082016-02-22Ratiopharm Gmbh O-linked glycosylation of G-CSF peptides
WO2006010143A2 (en)2004-07-132006-01-26Neose Technologies, Inc.Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
WO2006031811A2 (en)2004-09-102006-03-23Neose Technologies, Inc.Glycopegylated interferon alpha
EP3061461A1 (en)2004-10-292016-08-31ratiopharm GmbHRemodeling and glycopegylation of fibroblast growth factor (fgf)
MX2007008229A (en)2005-01-102007-09-11Neose Technologies IncGlycopegylated granulocyte colony stimulating factor.
US9187546B2 (en)2005-04-082015-11-17Novo Nordisk A/SCompositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
WO2006127910A2 (en)2005-05-252006-11-30Neose Technologies, Inc.Glycopegylated erythropoietin formulations
US20070105755A1 (en)2005-10-262007-05-10Neose Technologies, Inc.One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en)2005-11-032009-02-19Neose Technologies, Inc.Nucleotide Sugar Purification Using Membranes
WO2008011633A2 (en)2006-07-212008-01-24Neose Technologies, Inc.Glycosylation of peptides via o-linked glycosylation sequences
EP2054521A4 (en)2006-10-032012-12-19Novo Nordisk As METHODS OF PURIFYING CONJUGATES OF POLYPEPTIDES
PL2144923T3 (en)2007-04-032013-12-31Biogenerix AgMethods of treatment using glycopegylated g-csf
CN101778859B (en)2007-06-122014-03-26诺和诺德公司Improved process for the production of nucleotide sugars
US8207112B2 (en)2007-08-292012-06-26Biogenerix AgLiquid formulation of G-CSF conjugate
CA2715465C (en)2008-02-272017-03-21Novo Nordisk A/SConjugated factor viii molecules

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
FI82266C (en)*1982-10-191991-02-11Cetus Corp FOERFARANDE FOER FRAMSTAELLNING AV IL-2 MUTEIN.

Also Published As

Publication numberPublication date
WO1990008823A1 (en)1990-08-09
CA2005502C (en)2001-06-05
AU4663189A (en)1990-08-24
JP3207416B2 (en)2001-09-10
DK140491A (en)1991-07-29
JPH04503001A (en)1992-06-04
AU620673B2 (en)1992-02-20
EP0456642A1 (en)1991-11-21
DK140491D0 (en)1991-07-29

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