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BG60324B2 - New somatotropines - Google Patents

New somatotropines

Info

Publication number
BG60324B2
BG60324B2BG092028ABG9202890ABG60324B2BG 60324 B2BG60324 B2BG 60324B2BG 092028 ABG092028 ABG 092028ABG 9202890 ABG9202890 ABG 9202890ABG 60324 B2BG60324 B2BG 60324B2
Authority
BG
Bulgaria
Prior art keywords
somatotropines
new
somatotropins
glutamine
medicine
Prior art date
Application number
BG092028A
Other languages
Bulgarian (bg)
Inventor
Gwen Krivi
Michael Schlittler
Bernard Violand
Original Assignee
Monsanto Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto CompanyfiledCriticalMonsanto Company
Publication of BG60324B2publicationCriticalpatent/BG60324B2/en

Links

Classifications

Landscapes

Abstract

Translated fromUnknown language

Соматотропините намират приложение в медицината като растежен хормон. Описани са варианти на соматотропин, в които аспарагинът, локализиран в областта 95-101, е заменен с глутамин. Тези соматотропини показват увеличена стабилност. 25 претенцииSomatotropins are used in medicine as a growth hormone. Somatotropin variants have been described in which the asparagine located in the 95-101 region is replaced by glutamine. These somatotropins show increased stability. 25 claims

BG092028A1988-08-291990-05-16New somatotropinesBG60324B2 (en)

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
US07/237,358US5089473A (en)1988-08-291988-08-29Somatotropin variants and their use
PCT/US1989/003641WO1990002182A1 (en)1988-08-291989-08-28Novel somatotropins

Publications (1)

Publication NumberPublication Date
BG60324B2true BG60324B2 (en)1994-07-25

Family

ID=22893393

Family Applications (1)

Application NumberTitlePriority DateFiling Date
BG092028ABG60324B2 (en)1988-08-291990-05-16New somatotropines

Country Status (14)

CountryLink
US (1)US5089473A (en)
EP (2)EP0363342A1 (en)
JP (1)JP2784232B2 (en)
AU (1)AU614879B2 (en)
BG (1)BG60324B2 (en)
BR (1)BR8907068A (en)
CA (1)CA1340122C (en)
DE (1)DE68906261T2 (en)
ES (2)ES2016069A4 (en)
HU (1)HUT54409A (en)
IL (1)IL91457A (en)
NZ (1)NZ230458A (en)
WO (1)WO1990002182A1 (en)
ZA (1)ZA896557B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US5631227A (en)*1985-09-181997-05-20The Upjohn CompanySomatotropin analogs
US5130422A (en)*1988-08-291992-07-14Monsanto CompanyVariant somatotropin-encoding DNA
IE912345A1 (en)*1990-08-031992-02-12Pharmacia AbTreatment of human lactation failure
US20020137890A1 (en)*1997-03-312002-09-26Genentech, Inc.Secreted and transmembrane polypeptides and nucleic acids encoding the same
GB9823071D0 (en)*1998-10-211998-12-16Affibody Technology AbA method
US6238706B1 (en)1999-05-062001-05-29Grofish L.L.C.Method of stimulating growth in aquatic animals using growth hormones
WO2004022593A2 (en)*2002-09-092004-03-18Nautilus BiotechRational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
US7998930B2 (en)2004-11-042011-08-16Hanall Biopharma Co., Ltd.Modified growth hormones
US8592555B2 (en)2008-08-112013-11-26Emd Millipore CorporationImmunoglobulin-binding proteins with improved specificity
SG162687A1 (en)2008-12-242010-07-29Millipore CorpCaustic stable chromatography ligands
NZ593833A (en)2009-02-032013-10-25Amunix Operating IncExtended recombinant polypeptides and compositions comprising same
US8680050B2 (en)*2009-02-032014-03-25Amunix Operating Inc.Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same
US8703717B2 (en)2009-02-032014-04-22Amunix Operating Inc.Growth hormone polypeptides and methods of making and using same
US9849188B2 (en)2009-06-082017-12-26Amunix Operating Inc.Growth hormone polypeptides and methods of making and using same
SG10201604554WA (en)2011-06-082016-07-28Emd Millipore CorpChromatography matrices including novel staphylococcus aureus protein a based ligands

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
GR79124B (en)1982-12-221984-10-02Genentech Inc
US5037806A (en)*1985-02-221991-08-06Monsanto CompanyBiologically active method using somatotropins
ES8800957A1 (en)1985-02-221987-12-01Monsanto CoMethod of somatotropin solubilization and naturation.
DE3675382D1 (en)*1985-09-181990-12-06Upjohn Co INCREASED BIOLOGICAL EFFECT OF MAMMAL SOMATOTROPINE BY SELECTIVE DEAMIDATION.
EP0263206B1 (en)*1986-10-081990-12-12The Upjohn CompanyEnhanced bioactivity of mammalian somatotropin through selective deamidation
ES2070828T3 (en)1986-03-271995-06-16Monsanto Co STIMULATION OF PROTEIN PRODUCTION IN BACTERIA USING A NEW LINKAGE TO THE RIBOSOMA.
ATE198353T1 (en)*1988-08-242001-01-15American Cyanamid Co STABILIZATION OF SOMATOTROPINES THROUGH MODIFICATION OF CYSTEIN RESIDUE THROUGH SITE-SPECIFIC MUtagenesis OR CHEMICAL DERIVATIZATION

Also Published As

Publication numberPublication date
EP0403601B1 (en)1993-04-28
IL91457A (en)1994-04-12
JPH03501856A (en)1991-04-25
US5089473A (en)1992-02-18
ZA896557B (en)1990-08-29
EP0363342A1 (en)1990-04-11
DE68906261D1 (en)1993-06-03
AU614879B2 (en)1991-09-12
ES2054096T3 (en)1994-08-01
EP0403601A1 (en)1990-12-27
DE68906261T2 (en)1993-11-11
AU4316089A (en)1990-03-23
CA1340122C (en)1998-11-10
JP2784232B2 (en)1998-08-06
HUT54409A (en)1991-02-28
ES2016069A4 (en)1990-10-16
BR8907068A (en)1990-10-02
WO1990002182A1 (en)1990-03-08
IL91457A0 (en)1990-04-29
NZ230458A (en)1991-11-26

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