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| EP08075909AEP2067488A1 (en) | 2000-04-12 | 2001-04-12 | Albumin fusion proteins |
| EP01934875AEP1278767A4 (en) | 2000-04-12 | 2001-04-12 | Albumin fusion proteins |
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| EP (21) | EP1276856A4 (en) |
| JP (9) | JP2003530838A (en) |
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| CA (8) | CA2405563A1 (en) |
| DK (2) | DK2236152T3 (en) |
| ES (2) | ES2529300T3 (en) |
| FR (1) | FR16C0043I2 (en) |
| WO (7) | WO2001079442A2 (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2686899B1 (en)* | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| WO2002028877A1 (en)* | 2000-09-29 | 2002-04-11 | Human Genome Sciences, Inc. | 24 human secreted proteins |
| US20020137890A1 (en) | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| EP0892047A3 (en)* | 1997-07-09 | 2000-03-08 | Hoechst Marion Roussel Deutschland GmbH | Human and murine semaphorin L |
| US20030032103A1 (en)* | 1997-09-18 | 2003-02-13 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US20050181482A1 (en)* | 2004-02-12 | 2005-08-18 | Meade Harry M. | Method for the production of an erythropoietin analog-human IgG fusion proteins in transgenic mammal milk |
| AU775422B2 (en)* | 1998-06-15 | 2004-07-29 | Gtc Biotherapeutics, Inc. | Erythropoietin analog-human serum albumin fusion |
| US20040199099A1 (en)* | 1998-07-10 | 2004-10-07 | Matson James R | Hemofiltration systems, methods and devices used to treat inflammatory mediator related disease |
| MXPA01003770A (en) | 1998-10-13 | 2002-05-06 | Univ Georgia Res Found | Stabilized bioactive peptides and methods of identification, synthesis and use. |
| US20030190740A1 (en) | 1998-10-13 | 2003-10-09 | The University Of Georgia Research Foundation, Inc | Stabilized bioactive peptides and methods of identification, synthesis, and use |
| EP1696038B1 (en)* | 1999-05-05 | 2010-06-02 | Phylogica Limited | Isolating biological modulators from biodiverse gene fragment libraries |
| US6946129B1 (en)* | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
| US7592304B2 (en) | 1999-10-01 | 2009-09-22 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
| US7632803B2 (en) | 1999-10-01 | 2009-12-15 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
| JP2003528587A (en)* | 1999-10-29 | 2003-09-30 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | 27 human secretory proteins |
| EP1235845A4 (en)* | 1999-11-05 | 2003-06-25 | Human Genome Sciences Inc | 24 human secreted proteins |
| CA2389305A1 (en)* | 1999-11-05 | 2001-05-17 | Human Genome Sciences, Inc. | 28 human secreted proteins |
| CA2389724A1 (en)* | 1999-11-12 | 2001-05-17 | Human Genome Sciences, Inc. | 28 human secreted proteins |
| EP1234031B2 (en) | 1999-11-30 | 2021-11-24 | Mayo Foundation For Medical Education And Research | B7-h1, a novel immunoregulatory molecule |
| CA2921260A1 (en) | 1999-12-24 | 2001-06-28 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| US7534417B2 (en) | 2000-02-24 | 2009-05-19 | Agensys, Inc. | 103P2D6: tissue specific protein highly expressed in various cancers |
| US7291122B2 (en)* | 2000-03-24 | 2007-11-06 | Immunocept, L.L.C. | Hemofiltration methods for treatment of diseases in a mammal |
| US6946134B1 (en) | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20050100991A1 (en)* | 2001-04-12 | 2005-05-12 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| JP2003530838A (en)* | 2000-04-12 | 2003-10-21 | ヒューマン ゲノム サイエンシズ インコーポレイテッド | Albumin fusion protein |
| US7030219B2 (en)* | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
| US20030143654A1 (en)* | 2000-05-12 | 2003-07-31 | Matthias Grell | F-box containing protein |
| US6787040B2 (en)* | 2000-05-16 | 2004-09-07 | Immunocept, L.L.C. | Method and system for colloid exchange therapy |
| AU2001274923A1 (en)* | 2000-05-23 | 2001-12-03 | Lexicon Genetics Incorporated | Novel human thrombospondin-like proteins and polynucleotides encoding the same |
| AU2001275285A1 (en) | 2000-06-06 | 2001-12-17 | Bristol-Myers Squibb Company | B7-related nucleic acids and polypeptides and their uses for immunomodulation |
| WO2001094391A2 (en)* | 2000-06-08 | 2001-12-13 | Incyte Genomics, Inc. | Intracellular signaling proteins |
| JP2004503220A (en)* | 2000-06-21 | 2004-02-05 | アムジェン インコーポレイテッド | Secretory colonic epithelial stromal-1 polypeptide, nucleic acid encoding the same, and uses thereof |
| EP1311669A4 (en)* | 2000-08-18 | 2004-07-14 | Human Genome Sciences Inc | 11 human secreted proteins |
| AU2001232810A1 (en)* | 2000-08-18 | 2002-03-04 | Human Genome Sciences, Inc. | 23 human secreted proteins |
| AU2001229507A1 (en)* | 2000-08-18 | 2002-03-04 | Human Genome Sciences, Inc. | 21 human secreted proteins |
| CA2420902A1 (en)* | 2000-08-28 | 2002-03-07 | Craig A. Rosen | 18 human secreted proteins |
| CA2420192A1 (en)* | 2000-09-20 | 2002-03-28 | Human Genome Sciences, Inc. | 21 human secreted proteins |
| AU2001296235A1 (en)* | 2000-10-12 | 2002-04-22 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| US6531297B2 (en)* | 2000-10-20 | 2003-03-11 | Applera Corporation | Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof |
| US6949371B2 (en) | 2000-10-20 | 2005-09-27 | Applera Corporation | Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof |
| FR2815964A1 (en)* | 2000-10-30 | 2002-05-03 | Inst Nat Sante Rech Med | RENIN AND / OR PRORENIN RECEPTOR PROTEIN, NUCLEIC ACID ENCODING THE RECEPTOR AND THEIR APPLICATIONS |
| US6855493B2 (en) | 2000-11-28 | 2005-02-15 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
| US7074913B2 (en) | 2000-12-05 | 2006-07-11 | Wisconsin Alumni Research Foundation | Receptor for B anthracis toxin |
| CN101712722A (en) | 2000-12-07 | 2010-05-26 | 伊莱利利公司 | Glp-1 fusion proteins |
| US20030148920A1 (en)* | 2000-12-27 | 2003-08-07 | Steven Rosen | Sulfatases and methods of use thereof |
| WO2002053737A1 (en)* | 2000-12-28 | 2002-07-11 | Asahi Kasei Kabushiki Kaisha | Nf-kb activating gene |
| CA2433469A1 (en)* | 2001-02-23 | 2002-09-06 | Human Genome Sciences, Inc. | 83 human secreted proteins |
| CA2441006A1 (en)* | 2001-03-08 | 2002-09-19 | Hyseq, Inc. | Methods and materials relating to fibulin-like polypeptides and polynucleotides |
| EP2280030A3 (en) | 2001-04-10 | 2011-06-15 | Agensys, Inc. | Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers |
| US20060084794A1 (en)* | 2001-04-12 | 2006-04-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20050244931A1 (en)* | 2001-04-12 | 2005-11-03 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7507413B2 (en)* | 2001-04-12 | 2009-03-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20030119112A1 (en) | 2001-06-20 | 2003-06-26 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| WO2003005033A2 (en)* | 2001-07-06 | 2003-01-16 | Geneprot, Inc. | Carcinoma-related peptides |
| US8129504B2 (en) | 2001-08-30 | 2012-03-06 | Biorexis Technology, Inc. | Oral delivery of modified transferrin fusion proteins |
| US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
| WO2003030821A2 (en)* | 2001-10-05 | 2003-04-17 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| DE10251673A1 (en) | 2001-11-09 | 2003-07-10 | Hoffmann La Roche | Alström syndrome gene, gene variants, encoded protein and method for diagnosing Alström syndrome |
| KR100406760B1 (en)* | 2001-11-16 | 2003-11-21 | 신코엠 주식회사 | Semiconductor memory device |
| AU2002358144B2 (en) | 2001-12-17 | 2008-10-02 | Laboratoires Serono Sa | Chemokine mutants acting as chemokine antagonists |
| US20040082761A1 (en)* | 2001-12-18 | 2004-04-29 | Duggan Brendan M. | Cell adhesion proteins |
| US20060253913A1 (en)* | 2001-12-21 | 2006-11-09 | Yue-Jin Huang | Production of hSA-linked butyrylcholinesterases in transgenic mammals |
| KR101271635B1 (en)* | 2001-12-21 | 2013-06-12 | 휴먼 게놈 사이언시즈, 인코포레이티드 | Albumin fusion proteins |
| ES2425738T3 (en)* | 2001-12-21 | 2013-10-17 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
| WO2003059934A2 (en) | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20080194481A1 (en)* | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
| US7081446B2 (en)* | 2002-01-31 | 2006-07-25 | The Trustees Of Columbia University In The City Of New York | Long-acting follicle stimulating hormone analogues and uses thereof |
| US20060241027A1 (en)* | 2002-02-07 | 2006-10-26 | Hans-Peter Hauser | Hiv inhibiting proteins |
| KR20040089608A (en)* | 2002-02-07 | 2004-10-21 | 델타 바이오테크놀로지 리미티드 | HIV Inhibiting Proteins |
| US20050222023A1 (en)* | 2002-02-07 | 2005-10-06 | Hans-Peter Hauser | Albumin-fused kunitz domain peptides |
| DE10205520A1 (en)* | 2002-02-08 | 2003-08-14 | Aventis Behring Gmbh | Inhibitory, monoclonal antibody against the clotting factor VII activating protease |
| KR20040096592A (en)* | 2002-02-21 | 2004-11-16 | 와이어쓰 | Follistatin domain containing proteins |
| CA2477614A1 (en)* | 2002-03-05 | 2003-09-18 | Merck & Co., Inc. | Biomarker for efficacy of appetite suppressant drugs |
| US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
| CA2482529A1 (en)* | 2002-04-15 | 2003-10-30 | American National Red Cross | Method for detecting ligands and targets in a mixture |
| US20070015230A1 (en)* | 2002-04-15 | 2007-01-18 | Hammond David J | Identification and characterization of analytes from whole blood |
| US7319138B2 (en) | 2002-04-18 | 2008-01-15 | The General Hospital Corporation | Human DRG11-Responsive Axonal Guidance and Outgrowth of Neurite (DRAGON) proteins and variants thereof |
| US7141381B2 (en) | 2002-04-25 | 2006-11-28 | Bristol-Myers Squibb Company | Human leucine-rich repeat-containing proteins specifically expressed in the nervous system |
| GB0210464D0 (en)* | 2002-05-08 | 2002-06-12 | Svanborg Catharina | Therapeutic treatment |
| DE60333758D1 (en) | 2002-06-07 | 2010-09-23 | Dyax Corp | Prevention and reduction of ischemia |
| WO2003103589A2 (en)* | 2002-06-07 | 2003-12-18 | Zymogenetics, Inc. | Use of il-21 in cancer and other therapeutic applications |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
| US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
| US8029803B2 (en) | 2002-06-20 | 2011-10-04 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
| CN101172091B (en)* | 2007-09-25 | 2011-04-27 | 北京美福源生物医药科技有限公司 | Preparation process and application of fusion protein skin care product containing human serum albumin and skin cell growth factor |
| CN1241946C (en)* | 2002-07-01 | 2006-02-15 | 美国福源集团 | Human serum albumins recombined merge protein having hyperplasia stimulation function to multiple cells |
| KR100711145B1 (en)* | 2002-07-03 | 2007-04-24 | (주)넥스젠 | Fusion Polypeptide Comprising Epidermal Growth Factor and Human Serum Albumin |
| WO2004004649A2 (en)* | 2002-07-08 | 2004-01-15 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| JPWO2004009626A1 (en)* | 2002-07-22 | 2005-11-17 | アステラス製薬株式会社 | Rheumatoid arthritis-related novel gene |
| GB0217033D0 (en) | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
| CA2496002A1 (en)* | 2002-08-07 | 2004-02-19 | Delta Biotechnology Ltd. | Albumin-fused ciliary neurotrophic factor |
| US20060129082A1 (en)* | 2002-08-13 | 2006-06-15 | Jacek Rozga | Selective plasma exchange therapy |
| SI2386310T1 (en) | 2002-08-28 | 2019-03-29 | Dyax Corp. | Methods for preserving organs and tissues |
| ES2614274T3 (en)* | 2002-09-06 | 2017-05-30 | Alexion Pharmaceuticals, Inc. | Asthma treatment procedure using antibodies against complement component C5 |
| US9415102B2 (en) | 2002-09-06 | 2016-08-16 | Alexion Pharmaceuticals, Inc. | High concentration formulations of anti-C5 antibodies |
| US20050271660A1 (en)* | 2002-09-06 | 2005-12-08 | Alexion Pharmaceuticals, Inc. | Nebulization of monoclonal antibodies for treating pulmonary diseases |
| EP1539959A2 (en)* | 2002-09-18 | 2005-06-15 | Centre Hospitalier de l'Université de Montréal (CHUM) | Ghrh analogues |
| US7432351B1 (en) | 2002-10-04 | 2008-10-07 | Mayo Foundation For Medical Education And Research | B7-H1 variants |
| DE10254601A1 (en) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Gene products differentially expressed in tumors and their use |
| ATE401346T1 (en)* | 2002-12-20 | 2008-08-15 | Geneos Oy | ASTHMA SENSITIVITY LOCATION |
| WO2004058817A1 (en)* | 2002-12-26 | 2004-07-15 | Takeda Pharmaceutical Company Limited | Novel proteins and use thereof |
| EP1594530A4 (en)* | 2003-01-22 | 2006-10-11 | Human Genome Sciences Inc | Albumin fusion proteins |
| ES2380147T3 (en)* | 2003-02-11 | 2012-05-09 | Shire Human Genetic Therapies, Inc. | Diagnosis and treatment of multiple sulfatases and other deficiencies using a formylglycine generating enzyme (FGE) |
| US7862816B2 (en)* | 2003-03-12 | 2011-01-04 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| US7381410B2 (en)* | 2003-03-12 | 2008-06-03 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| WO2004082640A2 (en)* | 2003-03-19 | 2004-09-30 | New Century Pharmaceuticals, Inc. | Human serum albumin conjugates with therapeutic compounds |
| JP2007527206A (en)* | 2003-04-04 | 2007-09-27 | ユニバーシティ オブ ローザンヌ | Peptabody for cancer treatment |
| US7354584B2 (en) | 2003-04-11 | 2008-04-08 | Medimmune, Inc. | Recombinant IL-9 antibodies |
| WO2004094589A2 (en)* | 2003-04-18 | 2004-11-04 | Incyte Corporation | Secreted proteins |
| US20050079546A1 (en)* | 2003-05-01 | 2005-04-14 | Dasa Lipovsek | Serum albumin scaffold-based proteins and uses thereof |
| US6987270B2 (en) | 2003-05-07 | 2006-01-17 | General Electric Company | Method to account for event losses due to positron range in positron emission tomography and assay of positron-emitting isotopes |
| JP4817233B2 (en)* | 2003-06-30 | 2011-11-16 | 学校法人日本大学 | Extracellular matrix deposited protein |
| WO2005010040A1 (en) | 2003-07-15 | 2005-02-03 | Barros Research Institute | Eimeria tenella antigen for immunotherapy of coccidiosis |
| US8007805B2 (en)* | 2003-08-08 | 2011-08-30 | Paladin Labs, Inc. | Chimeric antigens for breaking host tolerance to foreign antigens |
| GB0320877D0 (en)* | 2003-09-05 | 2003-10-08 | Celltech R&D Ltd | A protein involved in carcinoma |
| ES2333971T3 (en) | 2003-11-04 | 2010-03-03 | Novartis Vaccines And Diagnostics, Inc. | ANTI-CD40 MONOCLONAL ANTIBODIES ANTAGONISTS AND PROCEDURES FOR USE. |
| EP1704164B1 (en)* | 2003-12-03 | 2011-12-28 | Kröz, Monika | Interleukin-11 fusion proteins |
| CN100379762C (en)* | 2003-12-08 | 2008-04-09 | 中国人民解放军军事医学科学院生物工程研究所 | Fusion protein of human serum albumin and interleukin 2 and its coding gene |
| US9050378B2 (en) | 2003-12-10 | 2015-06-09 | Board Of Regents, The University Of Texas System | N2S2 chelate-targeting ligand conjugates |
| US7371381B2 (en) | 2003-12-12 | 2008-05-13 | Amgen Inc. | Anti-galanin antibodies and uses thereof |
| GB0329722D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Modified plasmid and use thereof |
| GB0329681D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Gene expression technique |
| WO2005061704A1 (en)* | 2003-12-24 | 2005-07-07 | Takeda Pharmaceutical Company Limited | Preventive/remedy for cancer |
| PL1729795T3 (en) | 2004-02-09 | 2016-08-31 | Human Genome Sciences Inc | Albumin fusion proteins |
| SE0400489D0 (en)* | 2004-02-27 | 2004-02-27 | Biovitrum Ab | Therapeutic proteins |
| WO2005085472A2 (en)* | 2004-03-03 | 2005-09-15 | Evotec Neurosciences Gmbh | Diagnostic and therapeutic use of mal2 gene and protein for neurodegenerative diseases |
| US20050201959A1 (en)* | 2004-03-11 | 2005-09-15 | Vvii Newco 2003, Inc. | Methods and compositions for altering skin coloration |
| WO2005091891A2 (en)* | 2004-03-11 | 2005-10-06 | Kythera Biopharmaceuticals, Inc. | Compositions and methods for preventing and treating skin and hair conditions |
| DK1730196T3 (en) | 2004-03-12 | 2011-03-28 | Vasgene Therapeutics Inc | EphB4-binding antibodies to inhibit antiogenesis and tumor growth |
| EP1734991A4 (en)* | 2004-04-14 | 2012-10-24 | Avirid Inc | Compositions with modified nucleases targeted to viral nucleic acids and methods of use for prevention and treatment of viral diseases |
| PT2100904E (en)* | 2004-04-23 | 2010-09-24 | Conjuchem Biotechnologies Inc | Solid phase for use in a method for the purification of albumin conjugates |
| KR100599454B1 (en)* | 2004-04-27 | 2006-07-12 | 재단법인서울대학교산학협력재단 | New Uses of AIM3 to Act as Tumor Suppressor |
| DE102004024617A1 (en) | 2004-05-18 | 2005-12-29 | Ganymed Pharmaceuticals Ag | Differentially expressed in tumors gene products and their use |
| CN101002084A (en)* | 2004-06-03 | 2007-07-18 | 赛弗根生物系统股份有限公司 | Biomarkers for peripheral artery disease |
| US7906140B2 (en) | 2004-06-17 | 2011-03-15 | Virun, Inc. | Compositions for mucosal delivery of agents |
| EP2359842A1 (en) | 2004-07-14 | 2011-08-24 | University of Utah Research Foundation | Netrin-related compositions and uses |
| EP1784511A4 (en)* | 2004-08-13 | 2009-03-11 | Millennium Pharm Inc | Genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of prostate cancer |
| JP2008513540A (en) | 2004-09-21 | 2008-05-01 | メディミューン，インコーポレーテッド | Antibody to respiratory syncytial virus and method for producing vaccine for the virus |
| EP1799713B1 (en) | 2004-09-23 | 2014-11-05 | VasGene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| US20060078541A1 (en)* | 2004-10-01 | 2006-04-13 | Giles Brian C | Method and formula for stem cells' stimulation, targeting release, trafficking and homing |
| EP1810026B1 (en) | 2004-10-06 | 2018-04-18 | Mayo Foundation For Medical Education And Research | B7-h1 and pd-1 in treatment of renal cell carcinoma |
| WO2006042197A2 (en)* | 2004-10-11 | 2006-04-20 | The Board Of Trustees Of The Leland Standford Junior University | Use of del-1 in hair, bone and cartilage regeneration |
| RU2398776C2 (en) | 2004-10-25 | 2010-09-10 | Иммьюн Систем Ки Лтд | Thymus-specific protein |
| KR100583350B1 (en)* | 2004-11-03 | 2006-06-05 | (주)넥스젠 | Method for producing epithelial cell regeneration factor using a fusion protein containing FAS-1 domain |
| PT1809663E (en)* | 2004-11-09 | 2008-10-02 | Ares Trading Sa | Method for purifying fsh |
| JP5631533B2 (en) | 2004-12-23 | 2014-11-26 | ノボザイムス バイオファーマ デーコー アクティーゼルスカブ | Gene expression technology |
| WO2006072625A2 (en) | 2005-01-06 | 2006-07-13 | Novo Nordisk A/S | Anti-kir combination treatments and methods |
| US20060178301A1 (en)* | 2005-02-04 | 2006-08-10 | Mathias Jurs | Albumin-fused ciliary neurotrophic factor |
| CA2597924C (en) | 2005-02-15 | 2018-10-02 | Duke University | Anti-cd19 antibodies and uses in oncology |
| US20110230407A1 (en)* | 2005-03-14 | 2011-09-22 | Alexander Yuzhakov | Hepatocyte growth factor pathway activators in demyelinating diseases and central nervous system trauma |
| BRPI0609449A2 (en)* | 2005-03-23 | 2010-04-06 | Wyeth Corp | gdf-8 modulation agent detection |
| BRPI0609439A2 (en)* | 2005-03-23 | 2010-04-06 | Wyeth Corp | detection of an immune response to gdf-8 modulating agents |
| KR20080013878A (en) | 2005-04-18 | 2008-02-13 | 노보 노르디스크 에이/에스 | IL-21 variants |
| US7833979B2 (en)* | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
| PL1874821T3 (en) | 2005-04-26 | 2013-09-30 | Trion Pharma Gmbh | Combination of antibodies and glucocorticoids for treating cancer |
| US9345745B2 (en)* | 2005-04-29 | 2016-05-24 | Bo Wang | Methods for treating inflammatory disorders and traumatic brain injury using stabilized non-hematopoietic EPO short peptides |
| US8653028B2 (en) | 2005-04-29 | 2014-02-18 | Rui Rong Yuan | Erythropoietin-derived short peptide and its mimics as immuno/inflammatory modulators |
| US9585932B2 (en) | 2005-04-29 | 2017-03-07 | Peter C. Dowling | Use of EPO-derived peptide fragments for the treatment of neurodegenerative disorders |
| JP5047947B2 (en) | 2005-05-05 | 2012-10-10 | デューク ユニバーシティ | Anti-CD19 antibody treatment for autoimmune disease |
| CA2606334A1 (en)* | 2005-05-12 | 2006-11-12 | Zymogenetics, Inc. | Methods of using phhla2 to co-stimulate t-cells |
| CA2611861C (en) | 2005-06-08 | 2017-11-28 | The Brigham And Women's Hospital, Inc. | Methods and compositions for the treatment of persistent infections |
| WO2007014167A2 (en)* | 2005-07-22 | 2007-02-01 | Five Prime Therapeutics, Inc. | Compositions for and methods of treating epithelial diseases with growth factors |
| US8323666B2 (en)* | 2005-08-01 | 2012-12-04 | Allergan, Inc. | Botulinum toxin compositions |
| US8217147B2 (en) | 2005-08-10 | 2012-07-10 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| SI1917276T1 (en) | 2005-08-26 | 2018-05-31 | Ares Trading S.A. | Process for the preparation of glycosylated interferon beta |
| US7713715B2 (en)* | 2005-09-06 | 2010-05-11 | University Of Tennessee Research Foundation | Method for diagnosing infections |
| US7855279B2 (en)* | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
| JP2009509535A (en)* | 2005-09-27 | 2009-03-12 | アムニクス， インコーポレイテッド | Proteinaceous drugs and their use |
| US20090099031A1 (en)* | 2005-09-27 | 2009-04-16 | Stemmer Willem P | Genetic package and uses thereof |
| US7846445B2 (en)* | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
| CN101321863A (en)* | 2005-10-03 | 2008-12-10 | 阿斯利康(瑞典)有限公司 | Fusion proteins having a modulated half-life in plasma |
| US8168592B2 (en)* | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
| EP1790664A1 (en) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| EP1960419B1 (en)* | 2005-12-09 | 2016-03-16 | Ares Trading S.A. | Method for purifying fsh or a fsh mutant |
| WO2007075326A2 (en)* | 2005-12-09 | 2007-07-05 | Seattle Genetics, Inc. | Methods of using cd40 binding agents |
| US20130172274A1 (en) | 2005-12-20 | 2013-07-04 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
| US8841255B2 (en) | 2005-12-20 | 2014-09-23 | Duke University | Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides |
| JP2009520469A (en)* | 2005-12-22 | 2009-05-28 | コンジュクヘム ビオテクフノロギエス インコーポレイテッド | Method for the production of preformed conjugates of albumin and therapeutic agents |
| WO2007082144A2 (en)* | 2006-01-05 | 2007-07-19 | Mayo Foundation For Medical Education And Research | B7-h1 and survivin in cancer |
| US20090215084A1 (en)* | 2006-01-05 | 2009-08-27 | Mayo Foundation For Medical Education And Research | B7-h1 and b7-h4 in cancer |
| EP2025762A3 (en) | 2006-01-17 | 2009-09-30 | Health Research Inc. | Heteroduplex tracking assay |
| EP1816201A1 (en)* | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
| WO2007097961A1 (en)* | 2006-02-16 | 2007-08-30 | Massachusetts Eye & Ear Infirmary | Use of azurocidin inhibitors in prevention and treatment of ocular vascular leakage |
| EP2650306A1 (en) | 2006-03-06 | 2013-10-16 | Aeres Biomedical Limited | Humanized Anti-CD22 antibodies and their use in treatment of oncology, transplantation and autoimmune disease |
| KR20150064254A (en) | 2006-04-05 | 2015-06-10 | 애브비 바이오테크놀로지 리미티드 | Antibody purification |
| ATE474917T1 (en) | 2006-04-11 | 2010-08-15 | Csl Behring Gmbh | METHOD FOR INCREASE IN VIVO RECOVERY OF THERAPEUTIC POLYPEPTIDES |
| WO2007124361A2 (en)* | 2006-04-20 | 2007-11-01 | Mayo Foundation For Medical Education And Research | Soluble b7-h1 |
| EP2046367A4 (en) | 2006-06-07 | 2009-11-11 | Human Genome Sciences Inc | Albumin fusion proteins |
| AU2013202566C1 (en)* | 2006-06-14 | 2018-07-12 | Csl Behring Gmbh | Proteolytically cleavable fusion protein comprising a blood coagulation factor |
| ES2910207T3 (en)* | 2006-06-14 | 2022-05-11 | Csl Behring Gmbh | Proteolytically Cleavable Fusion Proteins Comprising a Blood Coagulation Factor |
| EP1867660A1 (en) | 2006-06-14 | 2007-12-19 | CSL Behring GmbH | Proteolytically cleavable fusion protein comprising a blood coagulation factor |
| US7939632B2 (en)* | 2006-06-14 | 2011-05-10 | Csl Behring Gmbh | Proteolytically cleavable fusion proteins with high molar specific activity |
| WO2008007146A1 (en)* | 2006-07-13 | 2008-01-17 | Upperton Limited | Process for preparing particles of proteinaceous material |
| ES2371495T3 (en) | 2006-07-24 | 2012-01-03 | Biorexis Pharmaceutical Corporation | EXENDINE FUSION PROTEINS. |
| CA2659809A1 (en)* | 2006-08-04 | 2008-02-14 | Pharmathene Inc. | Long half-life recombinant butyrylcholinesterase |
| WO2008030968A2 (en)* | 2006-09-06 | 2008-03-13 | Phase Bioscience, Inc. | Fusion peptide therapeutic compositions |
| CA2663083A1 (en) | 2006-09-08 | 2008-03-13 | Ambrx, Inc. | Modified human plasma polypeptide or fc scaffolds and their uses |
| US10925977B2 (en) | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
| US7803769B2 (en)* | 2006-10-25 | 2010-09-28 | Amgen Inc. | OSK1 peptide analogs and pharmaceutical compositions |
| WO2008049920A2 (en) | 2006-10-26 | 2008-05-02 | Novo Nordisk A/S | Il-21 variants |
| US20100041102A1 (en) | 2006-11-07 | 2010-02-18 | Ayesha Sitlani | Antagonists of pcsk9 |
| CN101622274A (en) | 2006-12-12 | 2010-01-06 | 比奥雷克西斯药物公司 | Transferrin fusion protein libraries |
| EP2115004A2 (en) | 2006-12-19 | 2009-11-11 | Ablynx N.V. | Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders |
| EP2514767A1 (en) | 2006-12-19 | 2012-10-24 | Ablynx N.V. | Amino acid sequences directed against a metalloproteinase from the ADAM family and polypeptides comprising the same for the treatment of ADAM-related diseases and disorders |
| EP1935430A1 (en)* | 2006-12-22 | 2008-06-25 | CSL Behring GmbH | Modified coagulation factors with prolonged in vivo half-life |
| EP2097096B1 (en) | 2006-12-22 | 2017-05-31 | CSL Behring GmbH | Modified coagulation factors with prolonged in vivo half-life |
| EP2450368A1 (en) | 2007-01-30 | 2012-05-09 | Epivax, Inc. | Regulatory t cell epitopes, compositions and uses thereof |
| CA2678001C (en) | 2007-02-12 | 2017-07-11 | Stefan Schulte | Therapeutic application of kazal-type serine protease inhibitors |
| US8263353B2 (en) | 2007-03-27 | 2012-09-11 | Merck Sharp & Dohme Corp. | Method for detecting autoprocessed, secreted PCSK9 |
| EP2703011A3 (en) | 2007-05-07 | 2014-03-26 | MedImmune, LLC | Anti-icos antibodies and their use in treatment of oncology, transplantation and autoimmune disease |
| SI3072525T1 (en) | 2007-05-14 | 2018-06-29 | Astrazeneca Ab | Methods of reducing basophil levels |
| JP5591691B2 (en)* | 2007-05-22 | 2014-09-17 | アムジエン・インコーポレーテツド | Compositions and methods for making biologically active fusion proteins |
| EP1997830A1 (en) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
| US8153595B2 (en) | 2007-07-13 | 2012-04-10 | The Johns Hopkins University | B7-DC variants immunogenic compositions and methods of use thereof |
| AU2008275911A1 (en)* | 2007-07-19 | 2009-01-22 | Arizona Board of Regents, a body corporate acting for and on behalf of Arizona State University | Self- anchoring MEMS intrafascicular neural electrode |
| EP2185701A4 (en)* | 2007-08-15 | 2011-03-02 | Amunix Operating Inc | Compositions and methods for modifying properties of biologically active polypeptides |
| MX338474B (en) | 2007-08-29 | 2016-04-18 | Sanofi Aventis | Humanized anti-cxcr5 antibodies, derivatives thereof and their uses. |
| JP2009055838A (en)* | 2007-08-31 | 2009-03-19 | Nipro Corp | Fusion protein, gene related to the fusion protein, vector, transformant and anti-inflammatory medicinal composition |
| JP5591701B2 (en)* | 2007-09-21 | 2014-09-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Targeted interferon with potent apoptotic and antitumor activity |
| EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| WO2009053358A1 (en)* | 2007-10-22 | 2009-04-30 | Merck Serono S.A. | Method for purifying fc-fusion proteins |
| CA2701221A1 (en)* | 2007-10-22 | 2009-04-30 | Merck Serono S.A. | Method for purifying an fc-containing protein |
| WO2009070642A1 (en) | 2007-11-28 | 2009-06-04 | Medimmune, Llc | Protein formulation |
| US8092804B2 (en) | 2007-12-21 | 2012-01-10 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4Rα)-173 |
| EP2245064B1 (en) | 2007-12-21 | 2014-07-23 | Medimmune Limited | BINDING MEMBERS FOR INTERLEUKIN-4 RECEPTOR ALPHA (IL-4Ralpha) |
| US20100311072A1 (en)* | 2008-01-28 | 2010-12-09 | Bristol-Myers Squibb Company | Fluorescence polarization binding assay for characterizing glucokinase ligands |
| AR070315A1 (en) | 2008-02-07 | 2010-03-31 | Merck & Co Inc | ANTIBODIES 1B20 ANTAGONISTS OF PCSK9 |
| AR070316A1 (en) | 2008-02-07 | 2010-03-31 | Merck & Co Inc | PCSK9 ANTAGONISTS (SUBTILISINE-KEXINA TYPE 9 PROPROTEIN) |
| WO2009111315A2 (en)* | 2008-02-29 | 2009-09-11 | Mayo Foundation For Medical Education And Research | Methods for reducing granulomatous inflammation |
| JP5020135B2 (en)* | 2008-03-19 | 2012-09-05 | ソニーモバイルコミュニケーションズ， エービー | Portable terminal device and computer program |
| WO2009121884A1 (en) | 2008-04-01 | 2009-10-08 | Novo Nordisk A/S | Insulin albumin conjugates |
| CN102056945A (en) | 2008-04-07 | 2011-05-11 | 埃博灵克斯股份有限公司 | Amino acid sequences directed against the Notch pathways and uses thereof |
| US9296810B2 (en) | 2008-05-02 | 2016-03-29 | Novartis Ag | Fibronectin-based binding molecules and uses thereof |
| DK2865760T3 (en)* | 2008-06-24 | 2018-01-15 | Csl Behring Gmbh | Factor VIII, Von Willebrand Factor or complexes thereof with extended in vivo half-life |
| AU2013202564B2 (en)* | 2008-06-24 | 2015-09-17 | Csl Behring Gmbh | Factor VIII, von Willebrand factor or complexes thereof with prolonged in vivo half-life |
| EP2926825A1 (en) | 2008-06-27 | 2015-10-07 | Duke University | Therapeutic agents comprising elastin-like peptides |
| CA2767331A1 (en) | 2008-07-10 | 2010-01-14 | Angion Biomedica Corp. | Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity |
| US9034325B2 (en) | 2008-07-22 | 2015-05-19 | Ablynx N.V. | Amino acid sequences directed against multitarget scavenger receptors and polypeptides |
| UA105009C2 (en) | 2008-08-05 | 2014-04-10 | Новартіс Аг | Compositions and methods for antibodies targeting complement protein c5 |
| US20110223188A1 (en)* | 2008-08-25 | 2011-09-15 | Solomon Langermann | Targeted costimulatory polypeptides and methods of use to treat cancer |
| EP2927240A1 (en) | 2008-08-25 | 2015-10-07 | Amplimmune, Inc. | Compositions of pd-1 antagonists and methods of use |
| WO2010027364A1 (en) | 2008-09-07 | 2010-03-11 | Glyconex Inc. | Anti-extended type i glycosphingolipid antibody, derivatives thereof and use |
| WO2010056804A1 (en) | 2008-11-12 | 2010-05-20 | Medimmune, Llc | Antibody formulation |
| WO2010059315A1 (en)* | 2008-11-18 | 2010-05-27 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
| JP5520961B2 (en) | 2008-11-28 | 2014-06-11 | エモリー ユニバーシティ | Methods for treating infections and tumors |
| PT4209510T (en)* | 2008-12-09 | 2024-04-02 | Hoffmann La Roche | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| WO2010068526A1 (en) | 2008-12-12 | 2010-06-17 | Merck Sharp & Dohme Corp. | Pcsk9 immunoassay |
| CN102307594A (en) | 2009-01-06 | 2012-01-04 | 戴埃克斯有限公司 | Treatment of mucositis with kallikrein inhibitors |
| JP5753095B2 (en) | 2009-01-16 | 2015-07-22 | テバ ファーマシューティカル インダストリーズ リミテッド | Stable preparation of recombinant human albumin-human granulocyte colony stimulating factor fusion protein |
| US8852608B2 (en) | 2009-02-02 | 2014-10-07 | Medimmune, Llc | Antibodies against and methods for producing vaccines for respiratory syncytial virus |
| US8703717B2 (en)* | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| US20110046060A1 (en) | 2009-08-24 | 2011-02-24 | Amunix Operating, Inc., | Coagulation factor IX compositions and methods of making and using same |
| NZ593833A (en)* | 2009-02-03 | 2013-10-25 | Amunix Operating Inc | Extended recombinant polypeptides and compositions comprising same |
| US8680050B2 (en)* | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
| KR101722961B1 (en) | 2009-02-11 | 2017-04-04 | 알부메딕스 에이/에스 | Albumin variants and conjugates |
| CA2755336C (en) | 2009-03-20 | 2015-07-14 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
| WO2010128142A1 (en) | 2009-05-07 | 2010-11-11 | Novozymes Biopharma Dk A/S | Method for purifying albumin |
| US11512326B2 (en)* | 2009-05-26 | 2022-11-29 | University Of Florida Research Foundation, Incorporated | Small angiotensin peptide expression system in mammalian cells |
| EP2258398A1 (en)* | 2009-05-26 | 2010-12-08 | Araclón Biotech, S. L. | Albumin-amyloid peptide conjugates and uses thereof |
| WO2010144508A1 (en) | 2009-06-08 | 2010-12-16 | Amunix Operating Inc. | Glucose-regulating polypeptides and methods of making and using same |
| US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| EP3381937A3 (en) | 2009-08-13 | 2018-10-31 | The Johns Hopkins University | Methods of modulating immune function |
| AU2010284977A1 (en) | 2009-08-20 | 2012-03-29 | Csl Behring Gmbh | Albumin fused coagulation factors for non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders |
| US9044580B2 (en) | 2009-08-24 | 2015-06-02 | Arsenal Medical, Inc. | In-situ forming foams with outer layer |
| US9173817B2 (en) | 2009-08-24 | 2015-11-03 | Arsenal Medical, Inc. | In situ forming hemostatic foam implants |
| US20110202016A1 (en)* | 2009-08-24 | 2011-08-18 | Arsenal Medical, Inc. | Systems and methods relating to polymer foams |
| US10420862B2 (en) | 2009-08-24 | 2019-09-24 | Aresenal AAA, LLC. | In-situ forming foams for treatment of aneurysms |
| US8451450B2 (en)* | 2009-09-14 | 2013-05-28 | Bio-Rad Laboratories, Inc. | Near real time optical phase conjugation |
| UY32920A (en) | 2009-10-02 | 2011-04-29 | Boehringer Ingelheim Int | BISPECIFIC UNION MOLECULES FOR ANTI-ANGIOGENESIS THERAPY |
| US20110195494A1 (en) | 2009-10-02 | 2011-08-11 | Boehringer Ingelheim International Gmbh | Dll4-binging molecules |
| US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
| DK2486141T3 (en) | 2009-10-07 | 2018-04-23 | Macrogenics Inc | FC-REGION-CONTAINING POLYPEPTIDES THAT PROVIDE IMPROVED EFFECTOR FUNCTION BASED ON CHANGES OF THE SCOPE OF FUCOSYLATION AND PROCEDURES FOR THEIR USE |
| WO2011051278A1 (en)* | 2009-10-26 | 2011-05-05 | Externautics S.P.A. | Lung tumor markers and methods of use thereof |
| EP2493507A4 (en) | 2009-10-30 | 2013-11-20 | Merck Sharp & Dohme | ANTAGONISTS AND VARIANTS AX213 AND AX132 PCSK9 |
| AU2010313381A1 (en) | 2009-10-30 | 2012-04-12 | Merck Sharp & Dohme Corp. | AX1 and AX189 PCSK9 antagonists and variants |
| CN105567699A (en) | 2009-10-30 | 2016-05-11 | 诺维信生物制药丹麦公司 | Albumin variants |
| WO2011051327A2 (en) | 2009-10-30 | 2011-05-05 | Novartis Ag | Small antibody-like single chain proteins |
| WO2011051466A1 (en) | 2009-11-02 | 2011-05-05 | Novartis Ag | Anti-idiotypic fibronectin-based binding molecules and uses thereof |
| WO2011060528A1 (en)* | 2009-11-17 | 2011-05-26 | Universite De Montreal | Heteropeptides useful for reducing nonspecific adsorption |
| EP3326643B1 (en)* | 2009-12-06 | 2021-04-07 | Bioverativ Therapeutics Inc. | Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof |
| AU2010328305B2 (en) | 2009-12-08 | 2015-05-14 | Teva Pharmaceutical Industries Ltd. | BChE albumin fusions for the treatment of cocaine abuse |
| EP3309176B1 (en) | 2009-12-14 | 2025-10-01 | Ablynx N.V. | Immunoglobulin single variable domain antibodies against ox40l, constructs and their therapeutic use |
| US8729245B2 (en) | 2009-12-21 | 2014-05-20 | Pharmathene, Inc. | Recombinant butyrylcholinesterases and truncates thereof |
| EP4011917A1 (en) | 2010-01-06 | 2022-06-15 | Takeda Pharmaceutical Company Limited | Plasma kallikrein binding proteins |
| AR079944A1 (en) | 2010-01-20 | 2012-02-29 | Boehringer Ingelheim Int | NEUTRALIZING ANTIBODY OF THE ACTIVITY OF AN ANTICOAGULANT |
| EP2525833A2 (en) | 2010-01-22 | 2012-11-28 | Novo Nordisk Health Care AG | Stable growth hormone compounds |
| SI2525834T1 (en) | 2010-01-22 | 2019-10-30 | Novo Nordisk Healthcare Ag | Growth hormones with prolonged in-vivo efficacy |
| WO2011092233A1 (en) | 2010-01-29 | 2011-08-04 | Novartis Ag | Yeast mating to produce high-affinity combinations of fibronectin-based binders |
| US9120855B2 (en) | 2010-02-10 | 2015-09-01 | Novartis Ag | Biologic compounds directed against death receptor 5 |
| WO2011100460A2 (en)* | 2010-02-11 | 2011-08-18 | Ecole Polytechnique Federale De Lausanne | Ccr7 ligand delivery and co-delivery in immunotherapy |
| AU2011222980B2 (en) | 2010-03-03 | 2016-08-11 | Ablynx N.V. | Biparatopic Abeta binding polypeptides |
| EP2371857A1 (en) | 2010-04-01 | 2011-10-05 | CSL Behring GmbH | Factor XII inhibitors for treating interstitial lung disease |
| US10233228B2 (en) | 2010-04-09 | 2019-03-19 | Albumedix Ltd | Albumin derivatives and variants |
| US9290573B2 (en) | 2010-05-06 | 2016-03-22 | Novartis Ag | Therapeutic low density lipoprotein-related protein 6 (LRP6) multivalent antibodies |
| EP3345926B1 (en) | 2010-05-06 | 2023-04-05 | Novartis AG | Compositions and methods of use for therapeutic low density lipoprotein-related protein 6 (lrp6) antibodies |
| MX2012013490A (en) | 2010-05-20 | 2013-01-29 | Ablynx Nv | BIOLOGICAL MATERIALS RELATED TO HER3. |
| KR20220097518A (en) | 2010-07-09 | 2022-07-07 | 바이오버라티브 테라퓨틱스 인크. | Factor ix polypeptides and methods of use thereof |
| EP3508573A1 (en) | 2010-07-09 | 2019-07-10 | Bioverativ Therapeutics Inc. | Systems for factor viii processing and methods thereof |
| WO2012019061A2 (en) | 2010-08-05 | 2012-02-09 | Stem Centrx, Inc. | Novel effectors and methods of use |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| WO2012021512A2 (en) | 2010-08-10 | 2012-02-16 | Ecole Polytechnique Federale De Lausanne | Erythrocyte-binding therapeutics |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| PL2606070T4 (en) | 2010-08-20 | 2017-06-30 | Novartis Ag | Antibodies for epidermal growth factor receptor 3 (her3) |
| PH12013500379A1 (en) | 2010-08-27 | 2013-03-25 | Abbvie Stemcentrx Llc | Notum protein modulators and methods of use |
| CN106620693A (en) | 2010-09-03 | 2017-05-10 | 艾伯维施特姆森特克斯有限责任公司 | Novel modulators and methods of use |
| US20120225081A1 (en) | 2010-09-03 | 2012-09-06 | Boehringer Ingelheim International Gmbh | Vegf-binding molecules |
| JP6159660B2 (en) | 2010-09-22 | 2017-07-05 | アムジエン・インコーポレーテツド | Immunoglobulins as carriers and uses thereof |
| PT2621515T (en) | 2010-09-28 | 2017-07-12 | Aegerion Pharmaceuticals Inc | A chimeric seal-human leptin polypeptide with increased solubility |
| PL4108671T3 (en) | 2010-10-01 | 2025-02-24 | Modernatx, Inc. | MODIFIED NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS AND THEIR USES |
| US8892184B2 (en) | 2010-10-18 | 2014-11-18 | Siemens Medical Solutions Usa, Inc. | Systems and methods for reducing interference in a dual modality imaging system |
| US8853490B2 (en)* | 2010-10-26 | 2014-10-07 | Pioneer Hi Bred International Inc | Antifungal proteins and methods of use |
| US20130225496A1 (en) | 2010-11-01 | 2013-08-29 | Novozymes Biopharma Dk A/S | Albumin Variants |
| KR101973930B1 (en) | 2010-11-05 | 2019-04-29 | 자임워크스 인코포레이티드 | Stable heterodimeric antibody design with mutations in the fc domain |
| TWI619811B (en) | 2010-11-08 | 2018-04-01 | 諾華公司 | Chemokine receptor binding polypeptides |
| US9095606B1 (en) | 2010-11-13 | 2015-08-04 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| US9066974B1 (en) | 2010-11-13 | 2015-06-30 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| US20130245233A1 (en) | 2010-11-24 | 2013-09-19 | Ming Lei | Multispecific Molecules |
| RU2016123839A (en) | 2010-12-08 | 2018-11-30 | АббВай Стемсентркс ЭлЭлСи | New modulators and methods of their application |
| US10393757B2 (en) | 2010-12-28 | 2019-08-27 | Dainippon Sumitomo Pharma Co., Ltd. | Diagnostic drug and diagnostic method for Alzheimer's disease |
| US20120171195A1 (en) | 2011-01-03 | 2012-07-05 | Ravindranath Mepur H | Anti-hla-e antibodies, therapeutic immunomodulatory antibodies to human hla-e heavy chain, useful as ivig mimetics and methods of their use |
| US8816055B2 (en) | 2011-01-06 | 2014-08-26 | Dyax Corp. | Plasma kallikrein binding proteins |
| SA112330278B1 (en) | 2011-02-18 | 2015-10-09 | ستيم سينتركس، انك. | Novel modulators and methods of use |
| CA2828405A1 (en) | 2011-02-28 | 2012-09-07 | Istituto Di Ricovero E Cura A Carattere Scientifico Materno-Infantile Bu Rlo Garofolo - Ospedale Di Alta Specializzazione E Di Rilievo Nazionale | Apoptosis-inducing molecules and uses therefor |
| US9499605B2 (en) | 2011-03-03 | 2016-11-22 | Zymeworks Inc. | Multivalent heteromultimer scaffold design and constructs |
| EP2497489A1 (en) | 2011-03-09 | 2012-09-12 | CSL Behring GmbH | Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs |
| DK2683397T3 (en) | 2011-03-09 | 2017-09-18 | Csl Behring Gmbh | FACTOR XII INHIBITORS FOR ADMINISTRATION OF MEDICAL PROCEDURES COMPREHENSIVE CONTACT WITH ARTIFICIAL SURFACES |
| EP3235508B1 (en) | 2011-03-16 | 2020-12-30 | Sanofi | Compositions comprising a dual v region antibody-like protein |
| AP2013007173A0 (en) | 2011-03-16 | 2013-10-31 | Amgen Inc | Potent and selective inhibitors of NAV1.3 and NAV1.7 |
| WO2012135500A1 (en) | 2011-03-29 | 2012-10-04 | The General Hospital Corporation | Engineered thioredoxin-like fold proteins |
| JP2014515740A (en) | 2011-03-30 | 2014-07-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Anticoagulant antidote |
| DE12722942T1 (en) | 2011-03-31 | 2021-09-30 | Modernatx, Inc. | RELEASE AND FORMULATION OF MANIPULATED NUCLEIC ACIDS |
| US20130078247A1 (en) | 2011-04-01 | 2013-03-28 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to dii4 and ang2 |
| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| CN103596974B (en) | 2011-04-15 | 2016-08-31 | 卡姆普根有限公司 | Polypeptides and polynucleotides and their use for the treatment of immune-related disorders and cancer |
| EP2515112B1 (en)* | 2011-04-22 | 2015-08-12 | Sysmex Corporation | Method for electrochemically detecting analyte |
| US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| CA2830660A1 (en) | 2011-05-05 | 2012-11-08 | Novozymes Biopharma Dk A/S | Albumin variants |
| UA117218C2 (en) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | POLYPEPTIDE AGAINST IL-17A, IL-17F AND / OR IL17-A / F |
| US9561274B2 (en) | 2011-06-07 | 2017-02-07 | University Of Hawaii | Treatment and prevention of cancer with HMGB1 antagonists |
| WO2012170740A2 (en) | 2011-06-07 | 2012-12-13 | University Of Hawaii | Biomarker of asbestos exposure and mesothelioma |
| US9486507B2 (en) | 2011-06-10 | 2016-11-08 | Biogen Ma Inc. | Pro-coagulant compounds and methods of use thereof |
| WO2012172495A1 (en) | 2011-06-14 | 2012-12-20 | Novartis Ag | Compositions and methods for antibodies targeting tem8 |
| US20160145589A1 (en) | 2011-06-24 | 2016-05-26 | Green Cross Corporation | Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof |
| PT2726092T (en) | 2011-06-28 | 2019-10-08 | Lp Inhibrx | SERPINE FUSION POLYPEPTIDES AND METHODS FOR THEIR USE |
| KR20140054009A (en) | 2011-07-01 | 2014-05-08 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | Relaxin fusion polypeptides and uses thereof |
| EP2729492B1 (en) | 2011-07-05 | 2019-01-02 | Albumedix Ltd | Albumin formulation and use |
| WO2013007563A1 (en) | 2011-07-08 | 2013-01-17 | Bayer Intellectual Property Gmbh | Fusion proteins releasing relaxin and uses thereof |
| US20140256621A1 (en) | 2011-07-08 | 2014-09-11 | Astrazeneca Pharmaceuticals Lp | Engineered poypeptides having enhanced duration of action and reduced immunogenicity |
| KR20140053991A (en)* | 2011-07-18 | 2014-05-08 | 아츠 바이올로직스 에이/에스 | Long acting luteinizing hormone (lh) compound |
| BR112014001104B1 (en) | 2011-07-22 | 2022-12-06 | Csl Behring Gmbh | ANTIFACTOR XII/XIIA-BETA MONOCLONAL ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF, ITS PRODUCTION METHOD, NUCLEIC ACID, VECTOR, MEDICAL DEVICE AND PHARMACEUTICAL COMPOSITION |
| US20130058947A1 (en) | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc | Novel Modulators and Methods of Use |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| KR102014061B1 (en) | 2011-10-03 | 2019-08-28 | 모더나 세라퓨틱스, 인코포레이티드 | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| AU2012332593B2 (en) | 2011-11-01 | 2016-11-17 | Bionomics, Inc. | Anti-GPR49 antibodies |
| EP2773373B1 (en) | 2011-11-01 | 2018-08-22 | Bionomics, Inc. | Methods of blocking cancer stem cell growth |
| WO2013067057A1 (en) | 2011-11-01 | 2013-05-10 | Bionomics, Inc. | Anti-gpr49 antibodies |
| JP2014533247A (en) | 2011-11-01 | 2014-12-11 | バイオノミクス インコーポレイテッド | Antibodies and methods of treating cancer |
| US8993831B2 (en)* | 2011-11-01 | 2015-03-31 | Arsenal Medical, Inc. | Foam and delivery system for treatment of postpartum hemorrhage |
| KR102052774B1 (en) | 2011-11-04 | 2019-12-04 | 자임워크스 인코포레이티드 | Stable heterodimeric antibody design with mutations in the fc domain |
| JP2015502741A (en) | 2011-11-04 | 2015-01-29 | ノバルティス アーゲー | Low density lipoprotein related protein 6 (LRP6)-half-life extended construct |
| US20140315817A1 (en) | 2011-11-18 | 2014-10-23 | Eleven Biotherapeutics, Inc. | Variant serum albumin with improved half-life and other properties |
| UY34487A (en) | 2011-12-05 | 2013-07-31 | Novartis Ag | ANTIBODIES FOR EPIDERMAL GROWTH FACTOR RECEIVER 3 (HER3) |
| AU2012349736A1 (en) | 2011-12-05 | 2014-06-26 | Novartis Ag | Antibodies for epidermal growth factor receptor 3 (HER3) directed to domain II of HER3 |
| CA3018046A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| AU2012356170B2 (en) | 2011-12-21 | 2016-06-16 | Novartis Ag | Compositions and methods for antibodies targeting Factor P |
| EP2793935B1 (en) | 2011-12-22 | 2016-05-25 | CSL Behring GmbH | Use of c1-inhibitor for the treatment of secondary edema of the central nervous system |
| US20130177574A1 (en) | 2012-01-11 | 2013-07-11 | Paul I. Terasaki Foundation Laboratory | ANTI-HLA CLASS-Ib ANTIBODIES MIMIC IMMUNOREACTIVITY AND IMMUNOMODULATORY FUNCTIONS OF INTRAVENOUS IMMUNOGLOBULIN (IVIg) USEFUL AS THERAPEUTIC IVIg MIMETICS AND METHODS OF THEIR USE |
| US10800847B2 (en) | 2012-01-11 | 2020-10-13 | Dr. Mepur Ravindranath | Anti-HLA class-IB antibodies mimic immunoreactivity and immunomodulatory functions of intravenous immunoglobulin (IVIG) useful as therapeutic IVIG mimetics and methods of their use |
| CN109111526A (en) | 2012-01-12 | 2019-01-01 | 比奥贝拉蒂治疗公司 | Chimeric factor VIII polypeptide and application thereof |
| EP2623110A1 (en) | 2012-01-31 | 2013-08-07 | CSL Behring GmbH | Factor XII inhibitors for the treatment of neurological inflammatory disorders |
| HRP20192314T1 (en) | 2012-02-15 | 2020-03-20 | Bioverativ Therapeutics Inc. | Factor viii compositions and methods of making and using same |
| PL2814502T3 (en)* | 2012-02-15 | 2018-02-28 | Csl Behring Gmbh | Von willebrand factor variants having improved factor viii binding affinity |
| JP6692602B2 (en) | 2012-02-15 | 2020-05-13 | エコール・ポリテクニーク・フェデラル・ドゥ・ローザンヌ（ウペエフエル）Ｅｃｏｌｅ Ｐｏｌｙｔｅｃｈｎｉｑｕｅ Ｆｅｄｅｒａｌｅ ｄｅ Ｌａｕｓａｎｎｅ （ＥＰＦＬ） | Red blood cell binding therapeutic agent |
| WO2013123457A1 (en) | 2012-02-15 | 2013-08-22 | Biogen Idec Ma Inc. | Recombinant factor viii proteins |
| JP6089047B2 (en) | 2012-02-24 | 2017-03-01 | アッヴィ・ステムセントルクス・エル・エル・シー | DLL3 modulator and method of use |
| MD4548C1 (en) | 2012-02-27 | 2018-08-31 | Boehringer Ingelheim International Gmbh | CX3CR1-binding polypeptides |
| KR20140136934A (en) | 2012-03-16 | 2014-12-01 | 노보자임스 바이오파마 디케이 에이/에스 | Albumin variants |
| GB201204868D0 (en)* | 2012-03-20 | 2012-05-02 | San Raffaele Centro Fond | Peptides |
| US9592289B2 (en) | 2012-03-26 | 2017-03-14 | Sanofi | Stable IgG4 based binding agent formulations |
| JP6254146B2 (en) | 2012-03-27 | 2017-12-27 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | Compositions and methods for treating metabolic disorders |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| HK1206636A1 (en) | 2012-04-02 | 2016-01-15 | Modernatx, Inc. | Modified polynucleotides for the production of oncology-related proteins and peptides |
| US9334319B2 (en) | 2012-04-20 | 2016-05-10 | Abbvie Inc. | Low acidic species compositions |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| CA2871458C (en)* | 2012-04-27 | 2020-06-23 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof |
| WO2013166290A1 (en) | 2012-05-04 | 2013-11-07 | Abbvie Biotherapeutics Inc. | P21 biomarker assay |
| US9328174B2 (en) | 2012-05-09 | 2016-05-03 | Novartis Ag | Chemokine receptor binding polypeptides |
| WO2013167153A1 (en) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Antibodies useful in cancer diagnosis |
| US20130336973A1 (en) | 2012-05-10 | 2013-12-19 | Zymeworks Inc. | Heteromultimer Constructs of Immunoglobulin Heavy Chains with Mutations in the Fc Domain |
| WO2013177386A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Biotherapeutics Inc. | Biomarkers for predicting response to tweak receptor (tweakr) agonist therapy |
| WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
| ES2859773T3 (en) | 2012-05-30 | 2021-10-04 | Bayer Cropscience Ag | Composition comprising a biological control agent and a fungicide |
| ES2698951T3 (en) | 2012-05-30 | 2019-02-06 | Bayer Cropscience Ag | Compositions comprising a biological control agent and an insecticide |
| EP2854551A1 (en) | 2012-05-30 | 2015-04-08 | Bayer Cropscience AG | Compositions comprising a biological control agent and a fungicide from the group consisting of inhibitors of the respiratory chain at complex i or ii. |
| IN2014DN09381A (en) | 2012-05-30 | 2015-07-17 | Bayer Cropscience Ag | |
| KR20150021502A (en) | 2012-05-30 | 2015-03-02 | 바이엘 크롭사이언스 아게 | Compositions comprising a biological control agent and an insecticide |
| EP3318128A3 (en) | 2012-05-30 | 2018-06-27 | Bayer CropScience Aktiengesellschaft | Composition comprising a biological control agent and a fungicide |
| WO2013178661A1 (en) | 2012-05-30 | 2013-12-05 | Bayer Cropscience Ag | Compositiions comprising a biological control agent and an insecticide |
| CN106962403B (en) | 2012-05-30 | 2020-05-05 | 拜耳作物科学股份公司 | Compositions comprising biological control agents and pesticides |
| HRP20181752T1 (en) | 2012-05-30 | 2018-12-28 | Bayer Cropscience Ag | Composition comprising a biological control agent and fluopicolide |
| IN2014DN10220A (en) | 2012-05-30 | 2015-08-07 | Bayer Cropscience Ag | |
| AR091195A1 (en) | 2012-05-30 | 2015-01-21 | Bayer Cropscience Ag | COMPOSITION THAT INCLUDES A BIOLOGICAL CONTROL AGENT AND A FUNGICIDE |
| CN104507318B (en) | 2012-05-30 | 2018-12-25 | 拜尔农作物科学股份公司 | The composition of fungicide including biocontrol agent and from electron transport chain complex III inhibitor |
| WO2013185113A1 (en) | 2012-06-08 | 2013-12-12 | Biogen Idec Ma Inc. | Procoagulant compounds |
| WO2013185114A2 (en) | 2012-06-08 | 2013-12-12 | Biogen Idec Ma Inc. | Chimeric clotting factors |
| KR101380740B1 (en) | 2012-06-29 | 2014-04-11 | 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 | Purification of iduronate-2-sulfatase |
| US9150841B2 (en) | 2012-06-29 | 2015-10-06 | Shire Human Genetic Therapies, Inc. | Cells for producing recombinant iduronate-2-sulfatase |
| US10656156B2 (en) | 2012-07-05 | 2020-05-19 | Mepur Ravindranath | Diagnostic and therapeutic potential of HLA-E monospecific monoclonal IgG antibodies directed against tumor cell surface and soluble HLA-E |
| EP2882450B1 (en) | 2012-07-11 | 2019-11-27 | Bioverativ Therapeutics Inc. | Factor viii complex with xten and von willebrand factor protein, and uses thereof |
| IN2015DN01115A (en) | 2012-07-13 | 2015-06-26 | Zymeworks Inc | |
| US20150202287A1 (en) | 2012-08-30 | 2015-07-23 | Merrimack Pharmaceuticals, Inc. | Combination therapies comprising anti-erbb3 agents |
| HK1211981A1 (en) | 2012-09-02 | 2016-06-03 | Abbvie Inc. | Methods to control protein heterogeneity |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| US10391152B2 (en) | 2012-10-18 | 2019-08-27 | Bioverativ Therapeutics Inc. | Methods of using a fixed dose of a clotting factor |
| JP6487328B2 (en) | 2012-11-08 | 2019-03-20 | アルブミディクス リミティド | Albumin variant |
| NZ707831A (en) | 2012-11-13 | 2018-11-30 | Astellas Pharma Inc | Agents for treatment of claudin expressing cancer diseases |
| SMT202200337T1 (en) | 2012-11-26 | 2022-09-14 | Modernatx Inc | Terminally modified rna |
| WO2014084859A1 (en) | 2012-11-30 | 2014-06-05 | Novartis Ag | Molecules and methods for modulating tmem16a activities |
| HUE053669T2 (en) | 2012-12-05 | 2021-07-28 | Novartis Ag | Compositions and methods for antibodies targeting epo |
| WO2014099984A1 (en) | 2012-12-20 | 2014-06-26 | Amgen Inc. | Apj receptor agonists and uses thereof |
| AR094481A1 (en) | 2013-01-15 | 2015-08-05 | Teva Pharma | FORMULATIONS OF ALBU-BCHE (ALBUMINA-BUTIRILCOLINESTERASA), PREPARATION AND ITS USES |
| KR101503907B1 (en)* | 2013-01-17 | 2015-03-20 | 서울대학교산학협력단 | Recombinant protein vaccine for preventing Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae infection diseases |
| CA2899170C (en) | 2013-01-30 | 2022-08-02 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use in treating metabolic disorders |
| US9161966B2 (en) | 2013-01-30 | 2015-10-20 | Ngm Biopharmaceuticals, Inc. | GDF15 mutein polypeptides |
| JP2016511244A (en) | 2013-02-11 | 2016-04-14 | バイエル クロップサイエンス エルピーＢａｙｅｒ Ｃｒｏｐｓｃｉｅｎｃｅ Ｌｐ | Composition comprising a biocontrol agent based on the genus Streptomyces and another biocontrol agent |
| FI2956477T4 (en) | 2013-02-15 | 2024-04-24 | Bioverativ Therapeutics Inc | Optimized factor viii gene |
| ES2648591T3 (en) | 2013-02-16 | 2018-01-04 | Albumedix A/S | Pharmacokinetic animal model |
| ES2609070T3 (en) | 2013-02-28 | 2017-04-18 | Csl Behring Gmbh | Therapeutic agent for amniotic fluid embolism |
| USRE48805E1 (en) | 2013-03-06 | 2021-11-02 | Vision Global Holdings Ltd. | Method for cancer targeting treatment and detection of arginine using albumin-binding arginine deiminase fusion protein |
| US9255262B2 (en)* | 2013-03-06 | 2016-02-09 | Vision Global Holdings Ltd. | Albumin-binding arginine deminase and the use thereof |
| EP2964255B1 (en) | 2013-03-08 | 2020-11-04 | CSL Behring GmbH | Treatment and prevention of remote ischemia-reperfusion injury |
| EP2968613B1 (en) | 2013-03-11 | 2019-09-11 | University of Florida Research Foundation, Inc. | Delivery of card protein as therapy for occular inflammation |
| WO2014143205A1 (en) | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| US10344060B2 (en) | 2013-03-12 | 2019-07-09 | Amgen Inc. | Potent and selective inhibitors of Nav1.7 |
| WO2014159813A1 (en) | 2013-03-13 | 2014-10-02 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| US20160152686A1 (en) | 2013-03-13 | 2016-06-02 | Bristol-Myers Squibb Company | Fibronectin based scaffold domains linked to serum albumin or moiety binding thereto |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
| US9302005B2 (en) | 2013-03-14 | 2016-04-05 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| EP3611189A1 (en) | 2013-03-14 | 2020-02-19 | Novartis AG | Antibodies against notch 3 |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| JP6387392B2 (en) | 2013-03-15 | 2018-09-05 | バイオベラティブ セラピューティクス インコーポレイテッド | Factor IX polypeptide preparation |
| WO2014160958A1 (en) | 2013-03-29 | 2014-10-02 | Alexion Pharmaceuticals, Inc. | Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5 |
| CN105120887A (en) | 2013-04-05 | 2015-12-02 | 诺和诺德保健股份有限公司 | Growth hormone compound formulation |
| DK2796145T3 (en) | 2013-04-22 | 2018-01-29 | Csl Ltd | A covalent complex of von Willebrand factor and factor VIII linked by a disulfide bridge |
| US9562101B2 (en) | 2013-06-21 | 2017-02-07 | Novartis Ag | Lectin-like oxidized LDL receptor 1 antibodies and methods of use |
| AR096601A1 (en) | 2013-06-21 | 2016-01-20 | Novartis Ag | ANTIBODIES OF LEXINED OXIDATED LDL RECEIVER 1 AND METHODS OF USE |
| US20160166660A1 (en) | 2013-06-28 | 2016-06-16 | Csl Behring Gmbh | Combination therapy using a factor xii inhibitor and a c-1 inhibitor |
| EP4368194A3 (en) | 2013-06-28 | 2024-07-31 | Bioverativ Therapeutics Inc. | Thrombin cleavable linker with xten and its uses thereof |
| CN104342420B (en)* | 2013-07-30 | 2017-09-15 | 惠觅宙 | A kind of recombinant long-acting people hyaluronidase, its encoding gene, production method and application |
| EP3033097B1 (en) | 2013-08-14 | 2021-03-10 | Bioverativ Therapeutics Inc. | Factor viii-xten fusions and uses thereof |
| EP4108254A1 (en) | 2013-08-14 | 2022-12-28 | Bioverativ Therapeutics Inc. | Recombinant factor viii proteins |
| US9387151B2 (en) | 2013-08-20 | 2016-07-12 | Anutra Medical, Inc. | Syringe fill system and method |
| JP2016538318A (en) | 2013-08-28 | 2016-12-08 | ステムセントリックス， インコーポレイテッド | New SEZ6 modulator and method of use |
| CA2922547C (en) | 2013-08-28 | 2020-03-10 | Stemcentrx, Inc. | Site-specific antibody conjugation methods and compositions |
| WO2015048330A2 (en) | 2013-09-25 | 2015-04-02 | Biogen Idec Ma Inc. | On-column viral inactivation methods |
| CN103468662A (en)* | 2013-09-29 | 2013-12-25 | 惠觅宙 | Recombined human hyaluronidase, production and purification method and preparations thereof, use method and application |
| EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
| WO2015050663A1 (en) | 2013-10-01 | 2015-04-09 | Mayo Foundation For Medical Education And Research | Methods for treating cancer in patients with elevated levels of bim |
| BR112016007255A2 (en) | 2013-10-03 | 2017-09-12 | Moderna Therapeutics Inc | polynucleotides encoding low density lipoprotein receptor |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| WO2015057403A2 (en)* | 2013-10-17 | 2015-04-23 | Tarix Pharmaceuticals Ltd. | Compositions and methods for treatment of inflammatory bowel disease |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US9540440B2 (en) | 2013-10-30 | 2017-01-10 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof |
| PL3063275T3 (en) | 2013-10-31 | 2020-03-31 | Resolve Therapeutics, Llc | Therapeutic nuclease-albumin fusions and methods |
| KR101977449B1 (en) | 2013-11-01 | 2019-05-10 | 유니버시티에트 이 오슬로 | Albumin variants and uses thereof |
| US10584147B2 (en) | 2013-11-08 | 2020-03-10 | Biovertiv Therapeutics Inc. | Procoagulant fusion compound |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| US9737623B2 (en) | 2013-12-11 | 2017-08-22 | Cytomx Therapeutics, Inc. | Antibodies that bind activatable antibodies and methods of use thereof |
| US8980273B1 (en) | 2014-07-15 | 2015-03-17 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
| US8986691B1 (en) | 2014-07-15 | 2015-03-24 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
| ES2902835T3 (en) | 2014-01-09 | 2022-03-30 | Hadasit Med Res Service | Improved cell compositions and methods for cancer therapy |
| HRP20240640T1 (en) | 2014-01-10 | 2024-08-02 | Bioverativ Therapeutics Inc. | Factor viii chimeric proteins and uses thereof |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| EP3107563B1 (en) | 2014-02-21 | 2021-04-07 | Ecole Polytechnique Fédérale de Lausanne (EPFL) EPFL-TTO | Glycotargeting therapeutics |
| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| AU2015229381B2 (en) | 2014-03-11 | 2019-11-07 | University Of Florida Research Foundation, Inc. | Use of AAV-expressed M013 protein as an anti-inflammatory therapeutic |
| US20170107294A1 (en)* | 2014-03-21 | 2017-04-20 | Nordlandssykehuset Hf | Anti-cd14 antibodies and uses thereof |
| WO2015160618A1 (en) | 2014-04-16 | 2015-10-22 | Bayer Cropscience Lp | Compositions comprising ningnanmycin and a biological control agent |
| WO2015164615A1 (en) | 2014-04-24 | 2015-10-29 | University Of Oslo | Anti-gluten antibodies and uses thereof |
| RU2016144908A (en) | 2014-05-02 | 2018-06-05 | Серени Терапеутикс Холдинг Са | MARKERS OF HDL THERAPY |
| WO2015179654A1 (en) | 2014-05-22 | 2015-11-26 | Mayo Foundation For Medical Education And Research | Distinguishing antagonistic and agonistic anti b7-h1 antibodies |
| CN105198999A (en)* | 2014-05-27 | 2015-12-30 | 上海生物制品研究所有限责任公司 | Fusion protein and its preparation method and use |
| USD774182S1 (en) | 2014-06-06 | 2016-12-13 | Anutra Medical, Inc. | Anesthetic delivery device |
| USD763433S1 (en) | 2014-06-06 | 2016-08-09 | Anutra Medical, Inc. | Delivery system cassette |
| USD750768S1 (en) | 2014-06-06 | 2016-03-01 | Anutra Medical, Inc. | Fluid administration syringe |
| AU2015274574B2 (en) | 2014-06-10 | 2019-10-10 | Amgen Inc. | Apelin polypeptides |
| PL3157548T3 (en) | 2014-06-18 | 2022-01-17 | Csl Behring Gmbh | Therapy using a factor xii inhibitor in a neurotraumatic disorder |
| US20170204149A1 (en) | 2014-06-23 | 2017-07-20 | Novartis Ag | Hsa-gdf-15 fusion polypeptide and use thereof |
| US9272019B2 (en) | 2014-06-24 | 2016-03-01 | Novo Nordisk A/S | MIC-1 fusion proteins and uses thereof |
| WO2016004113A1 (en) | 2014-06-30 | 2016-01-07 | Biogen Ma Inc. | Optimized factor ix gene |
| US10517875B2 (en) | 2014-07-23 | 2019-12-31 | Mayo Foundation for Medical Engineering and Research | Targeting DNA-PKcs and B7-H1 to treat cancer |
| MX370115B (en) | 2014-07-30 | 2019-12-02 | Ngm Biopharmaceuticals Inc | Compositions and methods of use for treating metabolic disorders. |
| TW201613977A (en) | 2014-08-07 | 2016-04-16 | Novartis Ag | Angiopoetin-like 4 (ANGPTL4) antibodies and methods of use |
| NZ728425A (en) | 2014-08-07 | 2022-05-27 | Novartis Ag | Angiopoietin-like 4 antibodies and methods of use |
| RU2685869C1 (en)* | 2014-08-22 | 2019-04-23 | Нэшенл Ченг Кунг Юниверсити | Versions of disintegrin and their pharmaceutical application |
| EP3209130B1 (en) | 2014-09-17 | 2023-03-01 | BASF Corporation | Compositions comprising recombinant bacillus cells and another biological control agent |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| SG11201701803XA (en) | 2014-09-26 | 2017-04-27 | Bayer Pharma AG | Stabilized adrenomedullin derivatives and use thereof |
| MA41044A (en) | 2014-10-08 | 2017-08-15 | Novartis Ag | COMPOSITIONS AND METHODS OF USE FOR INCREASED IMMUNE RESPONSE AND CANCER TREATMENT |
| CA3203273A1 (en) | 2014-10-14 | 2016-04-21 | Halozyme, Inc. | Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same |
| MA40835A (en) | 2014-10-23 | 2017-08-29 | Biogen Ma Inc | ANTI-GPIIB / IIIA ANTIBODIES AND THEIR USES |
| MA40861A (en) | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | ANTI-GLYCOPROTEIN IIB / IIIA ANTIBODIES |
| DK3212226T3 (en) | 2014-10-31 | 2020-06-15 | Ngm Biopharmaceuticals Inc | COMPOSITIONS AND METHODS OF USE FOR TREATING METABOLIC DISORDERS |
| US20160130324A1 (en)* | 2014-10-31 | 2016-05-12 | Shire Human Genetic Therapies, Inc. | C1 Inhibitor Fusion Proteins and Uses Thereof |
| GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
| UY36449A (en) | 2014-12-19 | 2016-07-29 | Novartis Ag | COMPOSITIONS AND METHODS FOR ANTIBODIES DIRECTED TO BMP6 |
| JP6798993B2 (en) | 2014-12-23 | 2020-12-09 | メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン | Botulinum toxin prefilled container |
| EP3277725B1 (en)* | 2015-03-30 | 2020-11-25 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to fc gamma receptors |
| JP2016204292A (en)* | 2015-04-21 | 2016-12-08 | 国立大学法人 熊本大学 | Fusion of BMP7 mutant and albumin, and renal disease therapeutic agent containing the fusion |
| KR20170138569A (en)* | 2015-04-29 | 2017-12-15 | 메디오라늄 파마세우티시 에스.피.에이. | Soluble chimeric interleukin-10 receptor and its therapeutic use |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| WO2016195723A1 (en)* | 2015-06-03 | 2016-12-08 | Beller Pharmaceuticals LLC | Methods of treatment for conditions mediated by substance p |
| US10047155B2 (en) | 2015-06-05 | 2018-08-14 | Novartis Ag | Antibodies targeting bone morphogenetic protein 9 (BMP9) and methods therefor |
| US11752242B2 (en) | 2015-06-11 | 2023-09-12 | Ath Therapeutics Inc. | Medical devices, systems, and methods utilizing antithrombin-heparin composition |
| JOP20200312A1 (en) | 2015-06-26 | 2017-06-16 | Novartis Ag | Factor xi antibodies and methods of use |
| JP2018522030A (en)* | 2015-07-30 | 2018-08-09 | エンドール テクノロジーズ, エス.エレ.Endor Technologies, S.L. | Colony stimulating factor for the treatment of pancreatic or colon cancer |
| CA2994516A1 (en) | 2015-08-03 | 2017-02-09 | Novartis Ag | Methods of treating fgf21-associated disorders |
| CA2994547A1 (en) | 2015-08-03 | 2017-02-09 | Bioverativ Therapeutics Inc. | Factor ix fusion proteins and methods of making and using same |
| CA2994552A1 (en) | 2015-08-06 | 2017-02-09 | The Trustees Of The University Of Pennsylvania | Glucagon-like peptide 1 and use thereof in compositions for treating metabolic diseases |
| WO2017029407A1 (en) | 2015-08-20 | 2017-02-23 | Albumedix A/S | Albumin variants and conjugates |
| CN114591445B (en) | 2015-09-08 | 2024-04-23 | Jcr制药股份有限公司 | Novel human serum albumin mutant |
| EP3842457A1 (en) | 2015-09-09 | 2021-06-30 | Novartis AG | Thymic stromal lymphopoietin (tslp)-binding molecules and methods of using the molecules |
| AU2016320748B2 (en) | 2015-09-09 | 2019-05-02 | Novartis Ag | Thymic stromal lymphopoietin (TSLP)-binding antibodies and methods of using the antibodies |
| JP7299021B2 (en)* | 2015-09-11 | 2023-06-27 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Biorelevant Orthogonal Cytokine/Receptor Pairs |
| WO2017075045A2 (en) | 2015-10-30 | 2017-05-04 | Mayo Foundation For Medical Education And Research | Antibodies to b7-h1 |
| SI3383425T1 (en) | 2015-12-04 | 2020-11-30 | Boehringer Ingelheim International Gmbh | Biparatopic polypeptides antagonizing wnt signaling in tumor cells |
| EA201891388A1 (en) | 2015-12-11 | 2018-11-30 | Дайэкс Корп. | PLASMA KALLIKREIN INHIBITORS AND THEIR APPLICATION FOR THE TREATMENT OF THE EXPOSURE OF HEREDITARY ANGIONEUROTIC DOMESTIC |
| KR20180089510A (en) | 2015-12-18 | 2018-08-08 | 노파르티스 아게 | Antibodies targeting CD32b and methods of using the same |
| WO2017109706A1 (en) | 2015-12-22 | 2017-06-29 | Novartis Ag | Methods of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15) |
| BR112018014150A2 (en) | 2016-01-11 | 2018-12-11 | Novartis Ag | immunostimulating humanized monoclonal antibodies to human interleukin-2, and fusion proteins thereof |
| WO2017125897A1 (en) | 2016-01-21 | 2017-07-27 | Novartis Ag | Multispecific molecules targeting cll-1 |
| SI3411478T1 (en) | 2016-02-01 | 2022-10-28 | Bioverativ Therapeutics Inc. | Optimized factor VIII genes |
| JP2017165713A (en) | 2016-03-14 | 2017-09-21 | Ｊｃｒファーマ株式会社 | Serum albumin-20K growth hormone fusion protein |
| KR20220004226A (en) | 2016-03-22 | 2022-01-11 | 바이오노믹스 리미티드 | Administration of an anti-lgr5 monoclonal antibody |
| MY194669A (en) | 2016-03-31 | 2022-12-12 | Ngm Biopharmaceuticals Inc | Binding Proteins and Methods of use Thereof |
| US11174321B2 (en) | 2016-04-06 | 2021-11-16 | Csl Limited | Method of treating atherosclerosis |
| CN109071647B (en) | 2016-04-27 | 2022-11-22 | 诺华股份有限公司 | Antibody against growth differentiation factor 15 and use thereof |
| HUE053452T2 (en) | 2016-05-18 | 2021-07-28 | Boehringer Ingelheim Int | Anti-PD-1 and anti-LAG3 antibodies for the treatment of cancer |
| US20190248852A1 (en) | 2016-05-24 | 2019-08-15 | Novo Nordisk A/S | MIC-1 Compounds and Use Thereof |
| US11434269B2 (en) | 2016-06-15 | 2022-09-06 | Novartis Ag | Methods for treating disease using inhibitors of bone morphogenetic protein 6 (BMP6) |
| EP3481416B1 (en)* | 2016-07-08 | 2020-09-09 | CSL Behring Lengnau AG | Subcutaneous administration of long-acting factor ix in humans |
| WO2018014260A1 (en) | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
| US20190175683A1 (en) | 2016-08-05 | 2019-06-13 | Csl Behring Gmbh | Pharmaceutical formulations of c1 esterase inhibitor |
| CA3034568A1 (en) | 2016-08-23 | 2018-03-01 | Csl Behring Gmbh | Method of preventing acute attacks of hereditary angioedema associated with c1 esterase inhibitor deficiency |
| WO2018068201A1 (en) | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
| JP2020500306A (en) | 2016-11-04 | 2020-01-09 | オーフス ウニベルシテット | Identification and treatment of tumors characterized by neonatal Fc receptor overexpression |
| US11324804B2 (en)* | 2016-11-18 | 2022-05-10 | Sepsia Therapeutics, S.L. | Combined CD6 and imipenem therapy for treatment of infectious diseases and related inflammatory processes |
| WO2018096396A1 (en) | 2016-11-22 | 2018-05-31 | University Of Oslo | Albumin variants and uses thereof |
| BR112019011115A2 (en) | 2016-12-02 | 2019-10-01 | Bioverativ Therapeutics Inc | methods for treating hemophilic arthropathy using chimeric clotting factors |
| CA3044838A1 (en) | 2016-12-02 | 2018-06-07 | Bioverativ Therapeutics Inc. | Methods of inducing immune tolerance to clotting factors |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| EP3562840A1 (en) | 2016-12-16 | 2019-11-06 | Biogen MA Inc. | Stabilized proteolytically activated growth differentiation factor 11 |
| EP3360898A1 (en) | 2017-02-14 | 2018-08-15 | Boehringer Ingelheim International GmbH | Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer |
| CA3048479A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Gene editing of pcsk9 |
| CN110325550B (en) | 2016-12-23 | 2024-03-08 | 诺华股份有限公司 | Factor XI antibodies and methods of use |
| EP3558370A2 (en) | 2016-12-23 | 2019-10-30 | Novartis AG | Methods of treatment with anti-factor xi/xia antibodies |
| CA3088131A1 (en) | 2017-01-13 | 2018-07-19 | Pietro P. Sanna | Methods and compositions for treating hpa hyperactivity |
| WO2018144623A1 (en) | 2017-01-31 | 2018-08-09 | Bioverativ Therapeutics Inc. | Factor ix fusion proteins and methods of making and using same |
| EP3580237B1 (en) | 2017-02-08 | 2025-05-14 | Novartis AG | Fgf21 mimetic antibodies and uses thereof |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| JP2020517657A (en) | 2017-04-20 | 2020-06-18 | ノヴォ ノルディスク アー／エス | Purification method of albumin fusion protein |
| TWI710377B (en) | 2017-05-23 | 2020-11-21 | 丹麥商諾佛 儂迪克股份有限公司 | Mic-1 compounds and uses thereof |
| MY206158A (en) | 2017-05-24 | 2024-12-02 | Novartis Ag | Antibody-cytokine engrafted proteins and methods of use in the treatment of cancer |
| WO2018220080A1 (en) | 2017-05-31 | 2018-12-06 | Boehringer Ingelheim International Gmbh | Polypeptides antagonizing wnt signaling in tumor cells |
| EP3638296A1 (en) | 2017-06-16 | 2020-04-22 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
| EP3645034B1 (en) | 2017-06-29 | 2023-08-30 | CSL Behring Lengnau AG | 21-day dosing regimen for fusion proteins comprising factor ix and human albumin for prophylactic treatment of hemophilia and methods thereof |
| MA68842B1 (en) | 2017-08-04 | 2025-01-31 | Amgen Inc. | CYS-MABS CONJUGATION PROCESS |
| MX2020001593A (en) | 2017-08-09 | 2020-07-13 | Bioverativ Therapeutics Inc | NUCLEIC ACID MOLECULES AND USES THEREOF. |
| US11485781B2 (en) | 2017-08-17 | 2022-11-01 | Massachusetts Institute Of Technology | Multiple specificity binders of CXC chemokines |
| CA3075686A1 (en) | 2017-09-15 | 2019-03-21 | Cedars-Sinai Medical Center | Methods for improving organ function in organ transplant patients |
| AU2018350370B2 (en) | 2017-10-18 | 2023-05-04 | Csl Limited | Human serum albumin variants and uses thereof |
| WO2019081983A1 (en) | 2017-10-25 | 2019-05-02 | Novartis Ag | Antibodies targeting cd32b and methods of use thereof |
| EP3723804A4 (en) | 2017-12-15 | 2021-10-20 | CSL Limited | USE OF AN FXIIA INHIBITOR IN THE TREATMENT OF RENAL FIBROSIS AND / OR CHRONIC RENAL DISEASE |
| WO2019129054A1 (en) | 2017-12-27 | 2019-07-04 | 信达生物制药(苏州)有限公司 | Triabody, preparation method and use thereof |
| JP7369127B2 (en) | 2017-12-28 | 2023-10-25 | ナンジン レジェンド バイオテック カンパニー，リミテッド | Single domain antibodies against TIGIT and variants thereof |
| US11246908B2 (en)* | 2018-01-10 | 2022-02-15 | The Johns Hopkins University | Compositions comprising albumin-FMS-like tyrosine kinase 3 ligand fusion proteins and uses thereof |
| EP3740507A4 (en) | 2018-01-15 | 2022-08-24 | Nanjing Legend Biotech Co., Ltd. | SINGLE-DOMAIN ANTIBODIES AND VARIANTS THEREOF AGAINST PD-1 |
| CN111918674A (en) | 2018-02-01 | 2020-11-10 | 比奥维拉迪维治疗股份有限公司 | Use of Lentiviral Vectors Expressing Factor VIII |
| AU2019235634A1 (en) | 2018-03-13 | 2020-10-22 | Zymeworks Bc Inc. | Anti-HER2 biparatopic antibody-drug conjugates and methods of use |
| EP3765055B9 (en)* | 2018-03-13 | 2023-09-27 | Sepsia Therapeutics, S.L. | Bacterial-binding peptides for treatment of infectious diseases and related inflammatory processes |
| EP3774861A1 (en) | 2018-03-28 | 2021-02-17 | Bristol-Myers Squibb Company | Interleukin-2/interleukin-2 receptor alpha fusion proteins and methods of use |
| JP7346790B2 (en) | 2018-03-30 | 2023-09-20 | ナンジン レジェンド バイオテック カンパニー，リミテッド | Single domain antibodies against LAG-3 and their uses |
| KR102119197B1 (en)* | 2018-04-23 | 2020-06-05 | 주식회사 엘베이스 | Composition for autophagy inhibiting in cell, And pharmaceutical composition for preventing or treating tumor disease, or inhibiting anti-cancer agents resistance containing the same |
| SG11202011078VA (en) | 2018-05-09 | 2020-12-30 | Univ Chicago | Compositions and methods concerning immune tolerance |
| WO2019222294A1 (en) | 2018-05-14 | 2019-11-21 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| CA3100007A1 (en) | 2018-05-14 | 2019-11-21 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
| DK3793588T3 (en) | 2018-05-18 | 2025-06-16 | Bioverativ Therapeutics Inc | METHODS FOR TREATING HEMOPHILIA A |
| EP3569618A1 (en) | 2018-05-19 | 2019-11-20 | Boehringer Ingelheim International GmbH | Antagonizing cd73 antibody |
| TWI869346B (en) | 2018-05-30 | 2025-01-11 | 瑞士商諾華公司 | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
| US11492409B2 (en) | 2018-06-01 | 2022-11-08 | Novartis Ag | Binding molecules against BCMA and uses thereof |
| KR20210022004A (en) | 2018-06-18 | 2021-03-02 | 안위타 바이오사이언시스, 인코포레이티드 | Anti-mesothelin constructs and uses thereof |
| EP3817720A2 (en) | 2018-07-03 | 2021-05-12 | Bristol-Myers Squibb Company | Fgf21 formulations |
| MX2021001599A (en) | 2018-08-09 | 2021-07-02 | Bioverativ Therapeutics Inc | Nucleic acid molecules and uses thereof for non-viral gene therapy. |
| GB201813528D0 (en) | 2018-08-20 | 2018-10-03 | Ucl Business Plc | Factor IX encoding nucleotides |
| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
| ES3009025T3 (en) | 2018-08-31 | 2025-03-25 | Regeneron Pharma | Dosing strategy that mitigates cytokine release syndrome for cd3/cd20 bispecific antibodies |
| JP2022500427A (en)* | 2018-09-17 | 2022-01-04 | 国立大学法人京都大学 | Administration of anti-C5 agents for the treatment of liver injury or liver failure |
| KR20210087027A (en) | 2018-09-27 | 2021-07-09 | 실리오 디벨럽먼트, 인크. | Masked cytokine polypeptide |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| UY38407A (en) | 2018-10-15 | 2020-05-29 | Novartis Ag | TREM2 STABILIZING ANTIBODIES |
| WO2020092448A1 (en)* | 2018-10-29 | 2020-05-07 | Spin Therapeutics, Llc | Compositions and methods for alpha-1-antitrypsin disorders |
| US12264189B2 (en) | 2018-10-31 | 2025-04-01 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| GB201818477D0 (en) | 2018-11-13 | 2018-12-26 | Emstopa Ltd | Tissue plasminogen activator antibodies and method of use thereof |
| CN113396158A (en) | 2018-11-26 | 2021-09-14 | 诺华股份有限公司 | LPL-GPIHBP1 fusion polypeptide |
| TW202039855A (en) | 2018-12-06 | 2020-11-01 | 美商百歐維拉提夫治療公司 | Use of lentiviral vectors expressing factor ix |
| WO2020198075A2 (en) | 2019-03-22 | 2020-10-01 | Reflexion Pharmaceuticals, Inc. | Multivalent d-peptidic compounds for target proteins |
| EP3941580A1 (en) | 2019-03-22 | 2022-01-26 | Reflexion Pharmaceuticals, Inc. | D-peptidic compounds for vegf |
| EP3947442A2 (en) | 2019-03-28 | 2022-02-09 | Danisco US Inc. | Engineered antibodies |
| KR20220004083A (en) | 2019-04-11 | 2022-01-11 | 앤지온 바이오메디카 코포레이션 | Solid form of (E)-3-[2-(2-thienyl)vinyl]-1H-pyrazole |
| EP3969035A4 (en) | 2019-05-14 | 2023-06-21 | Werewolf Therapeutics, Inc. | SEPARATION UNITS AND METHODS AND THEIR USE |
| BR112021023048A2 (en) | 2019-05-21 | 2022-04-19 | Novartis Ag | cd19 binding molecules and uses thereof |
| WO2020236797A1 (en) | 2019-05-21 | 2020-11-26 | Novartis Ag | Variant cd58 domains and uses thereof |
| CN113891729A (en) | 2019-05-24 | 2022-01-04 | 赛诺菲 | Method of treating systemic sclerosis |
| CA3143584A1 (en) | 2019-06-18 | 2020-12-24 | Bayer Aktiengesellschaft | Adrenomedullin-analogues for long-term stabilization and their use |
| PE20220401A1 (en) | 2019-09-06 | 2022-03-22 | Novartis Ag | THERAPEUTIC FUSION PROTEINS |
| TW202124446A (en) | 2019-09-18 | 2021-07-01 | 瑞士商諾華公司 | Combination therapies with entpd2 antibodies |
| WO2021053559A1 (en) | 2019-09-18 | 2021-03-25 | Novartis Ag | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
| EP4038182A1 (en) | 2019-09-30 | 2022-08-10 | Bioverativ Therapeutics Inc. | Lentiviral vector formulations |
| EP4047006A4 (en)* | 2019-10-17 | 2023-11-01 | JCR Pharmaceuticals Co., Ltd. | METHOD FOR PRODUCING SERUM-ALBUMIN FUSION PROTEIN AND GROWTH HORMONE |
| EP4059512A4 (en) | 2019-10-30 | 2023-12-06 | JCR Pharmaceuticals Co., Ltd. | AQUEOUS PHARMACEUTICAL COMPOSITION CONTAINING SERUM ALBUMINE AND GROWTH HORMONE FUSION PROTEIN |
| MX2022005666A (en) | 2019-11-14 | 2022-10-07 | Werewolf Therapeutics Inc | ACTIVABLE CYTOKINE POLYPEPTIDES AND METHODS OF USE THEREOF. |
| EP4069200A1 (en) | 2019-12-04 | 2022-10-12 | Albumedix Ltd | Methods and compositions produced thereby |
| AU2020401371A1 (en) | 2019-12-13 | 2022-07-21 | Synthekine, Inc. | IL-2 orthologs and methods of use |
| US20210181200A1 (en)* | 2019-12-17 | 2021-06-17 | Women's College Hospital | Ovarian cancer biomarker and methods of using same |
| WO2021133822A1 (en) | 2019-12-24 | 2021-07-01 | Juvena Therapeutics,Inc. | Regenerative polypeptides and uses thereof |
| WO2021202473A2 (en) | 2020-03-30 | 2021-10-07 | Danisco Us Inc | Engineered antibodies |
| IL297193A (en) | 2020-04-09 | 2022-12-01 | Verve Therapeutics Inc | Base editing of pcsk9 and methods of using same for treatment of disease |
| CN116249555A (en) | 2020-05-19 | 2023-06-09 | 勃林格殷格翰国际有限公司 | Binding molecules for cancer treatment |
| WO2021257480A2 (en) | 2020-06-14 | 2021-12-23 | Catalyst Biosciences, Inc. | Complement factor i-related compositions and methods |
| KR20230074703A (en) | 2020-06-24 | 2023-05-31 | 바이오버라티브 테라퓨틱스 인크. | Method for removing free factor VIII from preparations of lentiviral vectors modified to express the protein |
| CN117043186A (en) | 2020-10-21 | 2023-11-10 | 勃林格殷格翰国际有限公司 | Agonistic TrkB binding molecules for the treatment of ocular diseases |
| JP2023547479A (en)* | 2020-10-30 | 2023-11-10 | シェンチェン、プロトゲン、リミテッド | Use of human serum albumin in the treatment of diseases |
| KR20230104651A (en) | 2020-11-06 | 2023-07-10 | 노파르티스 아게 | CD19 Binding Molecules and Uses Thereof |
| WO2022115865A2 (en) | 2020-11-25 | 2022-06-02 | Xilio Development, Inc. | Tumor-specific cleavable linkers |
| CN114478800B (en)* | 2021-02-05 | 2022-10-11 | 华南理工大学 | Serum albumin-based fusion protein, nano-assembly and preparation method and application thereof |
| CA3209052A1 (en) | 2021-02-19 | 2022-08-25 | Rafael Cristian CASELLAS | Single domain antibodies that neutralize sars-cov-2 |
| WO2022263507A1 (en) | 2021-06-17 | 2022-12-22 | Boehringer Ingelheim International Gmbh | Novel tri-specific binding molecules |
| MX2024000233A (en)* | 2021-06-21 | 2024-03-14 | Juvena Therapeutics Inc | Regenerative polypeptides and uses thereof. |
| CN114133458B (en)* | 2021-12-08 | 2023-11-14 | 福州大学 | A method for fusing polypeptides within human serum albumin |
| CR20240455A (en) | 2022-04-26 | 2024-12-20 | Novartis Ag | Multispecific antibodies targeting il-13 and il-18 |
| IL317689A (en) | 2022-07-15 | 2025-02-01 | Boehringer Ingelheim Int | Binding molecules for the treatment of cancer |
| EP4554619A1 (en) | 2022-07-15 | 2025-05-21 | Danisco US Inc. | Methods for producing monoclonal antibodies |
| WO2024083843A1 (en) | 2022-10-18 | 2024-04-25 | Confo Therapeutics N.V. | Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders |
| WO2024130158A1 (en) | 2022-12-16 | 2024-06-20 | Modernatx, Inc. | Lipid nanoparticles and polynucleotides encoding extended serum half-life interleukin-22 for the treatment of metabolic disease |
| TW202440624A (en)* | 2022-12-20 | 2024-10-16 | 澳大利亞商杰特創新股份有限公司 | Fcrn antagonists and uses thereof |
| EP4389762A1 (en) | 2022-12-23 | 2024-06-26 | Ospedale San Raffaele S.r.l. | Inhibitors of dux4 activity and their use in therapy. |
| WO2024178305A1 (en) | 2023-02-24 | 2024-08-29 | Modernatx, Inc. | Compositions of mrna-encoded il-15 fusion proteins and methods of use thereof for treating cancer |
| EP4442251A1 (en) | 2023-04-05 | 2024-10-09 | Albumedix Ltd | Formulations and uses thereof |
| WO2025034806A1 (en) | 2023-08-08 | 2025-02-13 | Wisconsin Alumni Research Foundation | Single-domain antibodies and variants thereof against fibroblast activation protein |
| WO2025072888A2 (en) | 2023-09-28 | 2025-04-03 | Novavax, Inc. | Anti-sars-cov-2 spike (s) antibodies and their use in treating covid-19 |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5625041A (en)* | 1990-09-12 | 1997-04-29 | Delta Biotechnology Limited | Purification of proteins |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| DE2449885C3 (en)* | 1974-10-21 | 1980-04-30 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Process for the production of chemically modified, long-life hemoglobin preparations as well as the modified hemoglobin preparation produced by this process |
| US4002531A (en) | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
| US4440859A (en)* | 1977-05-27 | 1984-04-03 | The Regents Of The University Of California | Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms |
| US4363877B1 (en) | 1977-09-23 | 1998-05-26 | Univ California | Recombinant dna transfer vectors |
| US4264731A (en)* | 1977-05-27 | 1981-04-28 | The Regents Of The University Of California | DNA Joining method |
| US4283489A (en) | 1977-09-23 | 1981-08-11 | The Regents Of The University Of California | Purification of nucleotide sequences suitable for expression in bacteria |
| US4407948A (en) | 1977-09-23 | 1983-10-04 | The Regents Of The University Of California | Purification of nucleotide sequences suitable for expression in bacteria |
| US4366246A (en) | 1977-11-08 | 1982-12-28 | Genentech, Inc. | Method for microbial polypeptide expression |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| US4447538A (en)* | 1978-04-19 | 1984-05-08 | Regents Of The University Of California | Microorganism containing gene for human chorionic somatomammotropin |
| US4652525A (en)* | 1978-04-19 | 1987-03-24 | The Regents Of The University Of California | Recombinant bacterial plasmids containing the coding sequences of insulin genes |
| US5514567A (en)* | 1979-01-30 | 1996-05-07 | Juridical Foundation, Japanese Foundation For Cancer Research | DNA and recombinant plasmid |
| US5326859A (en) | 1979-10-30 | 1994-07-05 | Juridical Foundation, Japanese Foundation For Cancer Research | DNA and recombinant plasmid |
| US4342832A (en) | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
| AU538665B2 (en) | 1979-10-30 | 1984-08-23 | Juridical Foundation, Japanese Foundation For Cancer Research | Human interferon dna |
| US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| FI86558C (en) | 1980-01-08 | 1992-09-10 | Biogen Inc | DNA sequences, recombinant DNA molecules and methods for producing human-type interferon and selection of the DNA sequence |
| US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
| IE57069B1 (en) | 1980-04-03 | 1992-04-22 | Biogen Inc | Dna sequences,recombinant dna molecules and processes for producing human fibroblast interferon |
| DE3023787A1 (en) | 1980-06-25 | 1982-01-21 | Studiengesellschaft Kohle mbH, 4330 Mülheim | METHOD FOR INCREASING THE INCORPORATION AND EXPRESSION OF GENETIC MATERIAL IN THE CORE OF INTACT CELLS BY LIPOSOME |
| US6610830B1 (en) | 1980-07-01 | 2003-08-26 | Hoffman-La Roche Inc. | Microbial production of mature human leukocyte interferons |
| IT1139487B (en) | 1980-09-25 | 1986-09-24 | Genentech Inc | MICROBIAL PRODUCTION OF HUMAN FIBROBLAST INTERFERON |
| US4456748A (en) | 1981-02-23 | 1984-06-26 | Genentech, Inc. | Hybrid human leukocyte interferons |
| EP0052322B1 (en) | 1980-11-10 | 1985-03-27 | Gersonde, Klaus, Prof. Dr. | Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application |
| DE3273787D1 (en) | 1981-02-04 | 1986-11-20 | Japan Found Cancer | Human interferon-beta gene |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| NZ199722A (en) | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
| JPS57149228A (en) | 1981-03-11 | 1982-09-14 | Ajinomoto Co Inc | Novel erythropoietin and its preparation |
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| CA1204682A (en) | 1981-06-19 | 1986-05-20 | Saran A. Narang | Adaptors, and synthesis and cloning of proinsulin genes |
| US4792602A (en) | 1981-06-19 | 1988-12-20 | Cornell Research Foundation, Inc. | Adaptors, and synthesis and cloning of proinsulin genes |
| US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
| US4714681A (en) | 1981-07-01 | 1987-12-22 | The Board Of Reagents, The University Of Texas System Cancer Center | Quadroma cells and trioma cells and methods for the production of same |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| IL66614A (en) | 1981-08-28 | 1985-09-29 | Genentech Inc | Method of constructing a dna sequence encoding a polypeptide,microbial production of human serum albumin,and pharmaceutical compositions comprising it |
| AU561343B2 (en) | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
| EP0079739A3 (en) | 1981-11-12 | 1984-08-08 | The Upjohn Company | Albumin-based nucleotides, their replication and use, and plasmids for use therein |
| EP0091527A3 (en) | 1981-12-14 | 1984-07-25 | The President And Fellows Of Harvard College | Dna sequences, recombinant dna molecules and processes for producing human serum albumin-like polypeptides |
| JPS58107298A (en) | 1981-12-21 | 1983-06-25 | Yoshitsuka Seiki:Kk | Phase adjusting device for shaker cam in powder molding press |
| JPS58118008A (en) | 1982-01-06 | 1983-07-13 | Nec Corp | Data processor |
| IT1167610B (en) | 1982-01-19 | 1987-05-13 | Cetus Corp | MULTICLASS HYBRID INTERFRERON, PHARMACEUTICAL COMPOSITION CONTAINING IT AND PRODUCTION PROCESS |
| DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
| US4450103A (en)* | 1982-03-01 | 1984-05-22 | Cetus Corporation | Process for recovering human IFN-β from a transformed microorganism |
| US4775622A (en) | 1982-03-08 | 1988-10-04 | Genentech, Inc. | Expression, processing and secretion of heterologous protein by yeast |
| US4670393A (en) | 1982-03-22 | 1987-06-02 | Genentech, Inc. | DNA vectors encoding a novel human growth hormone-variant protein |
| CA1341562C (en) | 1982-03-31 | 2007-11-27 | Tadatsugu Taniguchi | Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell |
| US4738927A (en) | 1982-03-31 | 1988-04-19 | Ajinomoto Co. Inc. | Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell line possessing the recombinant DNA, and method for producing interleukin-2 using the said cell |
| US5824330A (en) | 1982-04-20 | 1998-10-20 | Sloan-Kettering Institute For Cancer Research | Highly purified interleukin-2 and method |
| US4778879A (en) | 1982-04-20 | 1988-10-18 | Sloan-Kettering Institute For Cancer Research | Highly purified human interleukin 2 and method |
| US4925919A (en)* | 1984-04-25 | 1990-05-15 | Roland Mertelsmann | Purified interleukin 2 |
| US4499188A (en)* | 1982-05-05 | 1985-02-12 | Cetus Corporation | Bacterial production of heterologous polypeptides under the control of a repressible promoter-operator |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| DE3218121A1 (en) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Pharmaceutical compositions for tumour treatment |
| EP0102324A3 (en) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipids and surfactants in an aqueous medium |
| US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
| US4490289A (en) | 1982-09-16 | 1984-12-25 | Hoffmann-La Roche Inc. | Homogeneous human interleukin 2 |
| JPS5945835U (en) | 1982-09-16 | 1984-03-27 | 株式会社東芝 | Arc extinguishing device for circuit breakers and breakers |
| US4992271A (en) | 1982-09-23 | 1991-02-12 | Cetus Corporation | Formulation for lipophilic IL-2 proteins |
| US4462940A (en)* | 1982-09-23 | 1984-07-31 | Cetus Corporation | Process for the recovery of human β-interferon-like polypeptides |
| FI82266C (en) | 1982-10-19 | 1991-02-11 | Cetus Corp | FOERFARANDE FOER FRAMSTAELLNING AV IL-2 MUTEIN. |
| US4588585A (en) | 1982-10-19 | 1986-05-13 | Cetus Corporation | Human recombinant cysteine depleted interferon-β muteins |
| US4966843A (en)* | 1982-11-01 | 1990-10-30 | Cetus Corporation | Expression of interferon genes in Chinese hamster ovary cells |
| US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| EP0116201B1 (en) | 1983-01-12 | 1992-04-22 | Chiron Corporation | Secretory expression in eukaryotes |
| US4840934A (en)* | 1983-01-25 | 1989-06-20 | Eleanor Roosevelt Institute For Cancer Research, Inc. | Therapeutic method using T cell growth factor |
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4914026A (en)* | 1983-04-07 | 1990-04-03 | Chiron Corporation | Alpha factor leader sequence directed secretion of insulin |
| US5015575A (en)* | 1983-04-07 | 1991-05-14 | Chiron Corporation | Hybrid DNA synthesis of insulin |
| DK172738B1 (en) | 1983-04-07 | 1999-06-21 | Chiron Corp | Method for expressing mature insulin and DNA structure for use in the method |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| JPS60501140A (en) | 1983-04-22 | 1985-07-25 | アムジエン | Secretion of exogenous polypeptides by yeast |
| NZ207926A (en) | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
| US5010003A (en)* | 1983-04-25 | 1991-04-23 | Genentech, Inc. | Use of yeast homologous signals to secrete heterologous proteins |
| CA1196863A (en)* | 1983-06-08 | 1985-11-19 | Mattheus F.A. Goosen | Slow release injectable insulin composition |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US4576813A (en) | 1983-07-05 | 1986-03-18 | Monsanto Company | Heat recovery from concentrated sulfuric acid |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| JPS6087792A (en) | 1983-09-23 | 1985-05-17 | ジェネックス・コーポレイション | Variant control region |
| ATE59966T1 (en) | 1983-09-26 | 1991-02-15 | Ehrenfeld Udo | MEDICATION AND PRODUCT FOR THE DIAGNOSIS AND THERAPY OF TUMORS AND FOR THE TREATMENT OF WEAKNESSES IN THE CELLULAR AND HUMORAL IMMUNE DEFENSE. |
| US4518564A (en)* | 1983-10-03 | 1985-05-21 | Jeneric Industries, Inc. | Gallium and silver free, palladium based dental alloys for porcelain-fused-to-metal restorations |
| US4615885A (en) | 1983-11-01 | 1986-10-07 | Terumo Kabushiki Kaisha | Pharmaceutical composition containing urokinase |
| JPS60115528A (en) | 1983-11-28 | 1985-06-22 | Takeda Chem Ind Ltd | Human interleukin-2 protein, its production and pharmacological composition containing the same |
| GB8334102D0 (en) | 1983-12-21 | 1984-02-01 | Searle & Co | Interferons with cysteine pattern |
| US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| NZ210501A (en)* | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| US4855238A (en) | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
| GB8334261D0 (en) | 1983-12-22 | 1984-02-01 | Bass Plc | Fermentation processes |
| JPS60136596A (en) | 1983-12-26 | 1985-07-20 | Suntory Ltd | Peptide and diuretic comprising it as active ingredient |
| IT1185503B (en) | 1984-01-11 | 1987-11-12 | Univ New York | HUMAN Erythropietine ODNA CLONES |
| US4908434A (en)* | 1984-04-25 | 1990-03-13 | Sloan-Kettering Institute For Cancer Research | Process for preparing purified interleukin-2 |
| US4908433A (en)* | 1984-04-25 | 1990-03-13 | Sloan-Kettering Institute For Cancer Research | Uses of interleukin-2 |
| CA1213537A (en) | 1984-05-01 | 1986-11-04 | Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee | Polypeptide expression method |
| FR2564106B1 (en)* | 1984-05-09 | 1988-04-22 | Transgene Sa | FACTOR IX EXPRESSION VECTORS, CELLS TRANSFORMED BY THESE VECTORS, AND PROCESS FOR THE PREPARATION OF FACTOR IX. |
| DK58285D0 (en) | 1984-05-30 | 1985-02-08 | Novo Industri As | PEPTIDES AND MANUFACTURING AND USING THEREOF |
| EP0172619A1 (en) | 1984-06-20 | 1986-02-26 | Takeda Chemical Industries, Ltd. | Novel transformant and use thereof |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| US5908763A (en) | 1984-07-06 | 1999-06-01 | Novartis Corporation | DNA encoding GM-CSF and a method of producing GM-CSF protein |
| JPS61227526A (en) | 1984-07-25 | 1986-10-09 | Chugai Pharmaceut Co Ltd | Novel csf and method of collecting same |
| JPS6147500A (en) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | Chimeric monoclonal antibody and its production method |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4734491A (en) | 1984-08-31 | 1988-03-29 | University Patents, Inc. | DNA sequences encoding hybrid lymphoblastoid-leukocyte human interferons |
| US4716217A (en) | 1984-08-31 | 1987-12-29 | University Patents, Inc. | Hybrid lymphoblastoid-leukocyte human interferons |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US4959314A (en)* | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
| IL77081A (en) | 1984-12-04 | 1999-10-28 | Genetics Inst | Dna sequence encoding human erythropoietin process for the preparation thereof and a pharmaceutical composition of human erythropoietin |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5049386A (en) | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4677195A (en) | 1985-01-11 | 1987-06-30 | Genetics Institute, Inc. | Method for the purification of erythropoietin and erythropoietin compositions |
| US4970300A (en)* | 1985-02-01 | 1990-11-13 | New York University | Modified factor VIII |
| GB8504099D0 (en)* | 1985-02-18 | 1985-03-20 | Wellcome Found | Physiologically active substances |
| DK129385A (en) | 1985-03-22 | 1986-09-23 | Novo Industri As | PEPTIDES AND PREPARATION THEREOF |
| FR2579224B1 (en)* | 1985-03-25 | 1987-05-22 | Genetica | PROCESS FOR THE MICROBIOLOGICAL PREPARATION OF HUMAN SERUM-ALBUMIN |
| ATE63757T1 (en) | 1985-03-28 | 1991-06-15 | Chiron Corp | EXPRESSION THROUGH USE OF FUSION GENES FOR PROTEIN PRODUCTION. |
| US4751180A (en)* | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| CA1319120C (en) | 1985-04-01 | 1993-06-15 | John Henry Kenten | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
| GR860984B (en) | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
| GB8510219D0 (en) | 1985-04-22 | 1985-05-30 | Bass Plc | Isolation of fermentation products |
| EP0206733A1 (en) | 1985-06-17 | 1986-12-30 | Genex Corporation | Cloned human serum albumin gene |
| US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| US4810643A (en) | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| US5102872A (en)* | 1985-09-20 | 1992-04-07 | Cetus Corporation | Controlled-release formulations of interleukin-2 |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| JPH0618778B2 (en) | 1985-10-04 | 1994-03-16 | 中外製薬株式会社 | Leukopenia treatment |
| JPS6296086A (en) | 1985-10-21 | 1987-05-02 | Agency Of Ind Science & Technol | Composite plasmid |
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| CA1295563C (en) | 1985-11-01 | 1992-02-11 | Robert T. Garvin | Production of active proteins containing cystine residues |
| EP0247091B1 (en) | 1985-11-01 | 1993-09-29 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US5576195A (en) | 1985-11-01 | 1996-11-19 | Xoma Corporation | Vectors with pectate lyase signal sequence |
| US5641663A (en) | 1985-11-06 | 1997-06-24 | Cangene Corporation | Expression system for the secretion of bioactive human granulocyte macrophage colony stimulating factor (GM-CSF) and other heterologous proteins from steptomyces |
| CA1295566C (en) | 1987-07-21 | 1992-02-11 | Robert T. Garvin | Characterization and structure of genes for protease a and protease b from streptomyces griseus |
| JPH0780930B2 (en) | 1985-12-26 | 1995-08-30 | 三井石油化学工業株式会社 | Method for polymerizing α-olefin |
| JPH0645551B2 (en) | 1986-01-07 | 1994-06-15 | 塩野義製薬株式会社 | Interleukin-2 composition |
| ATE65403T1 (en) | 1986-01-22 | 1991-08-15 | Chugai Pharmaceutical Co Ltd | PHARMACEUTICAL SUBSTANCE FOR PROMOTING THE RESTORATION OF HAEMATOPOIETIC ABILITY. |
| ATE74272T1 (en) | 1986-01-22 | 1992-04-15 | Chugai Pharmaceutical Co Ltd | PHARMACEUTICAL SUBSTANCE FOR THE TREATMENT OF MYELOGOUS LEUKEMIA. |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| FR2594846B1 (en) | 1986-02-21 | 1989-10-20 | Genetica | PROCESS FOR THE PREPARATION OF MATURE HUMAN ALBUMIN SERUM |
| EP0237019A3 (en) | 1986-03-14 | 1988-03-09 | Toray Industries, Inc. | Interferon conjugate and production thereof using recombinant gene |
| IT1203758B (en) | 1986-03-27 | 1989-02-23 | Univ Roma | CLONING AND EXPRESSION VECTORS OF HETEROLOGICAL GENES IN YEASTS AND YEASES TRANSFORMED WITH SUCH CARRIERS |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| DK179286D0 (en) | 1986-04-18 | 1986-04-18 | Nordisk Gentofte | INSULIN PREPARATION |
| US4765980A (en)* | 1986-04-28 | 1988-08-23 | International Minerals & Chemical Corp. | Stabilized porcine growth hormone |
| US4859609A (en) | 1986-04-30 | 1989-08-22 | Genentech, Inc. | Novel receptors for efficient determination of ligands and their antagonists or agonists |
| US5028422A (en)* | 1986-05-27 | 1991-07-02 | Schering Corporation | Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon |
| US5985599A (en) | 1986-05-29 | 1999-11-16 | The Austin Research Institute | FC receptor for immunoglobulin |
| IT1204400B (en)* | 1986-06-20 | 1989-03-01 | Sclavo Spa | PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN |
| GB8615701D0 (en) | 1986-06-27 | 1986-08-06 | Delta Biotechnology Ltd | Stable gene integration vector |
| IT1196484B (en) | 1986-07-11 | 1988-11-16 | Sclavo Spa | YEAST EXPRESSION AND SECRETION VECTOR, USEFUL FOR THE PREPARATION OF HETEROLOGICAL PROTEINS |
| GR871067B (en) | 1986-07-18 | 1987-11-19 | Chugai Pharmaceutical Co Ltd | Process for producing stable pharmaceutical preparation containing granulocyte colony stimulating factor |
| US4857467A (en) | 1986-07-23 | 1989-08-15 | Phillips Petroleum Company | Carbon and energy source markers for transformation of strains of the genes Pichia |
| US4801575A (en)* | 1986-07-30 | 1989-01-31 | The Regents Of The University Of California | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US5002764A (en)* | 1986-08-12 | 1991-03-26 | Schering Corporation | Treatment of actinic keratoses with alpha2 interferon |
| GB8620926D0 (en) | 1986-08-29 | 1986-10-08 | Delta Biotechnology Ltd | Yeast promoter |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4929442A (en)* | 1986-09-26 | 1990-05-29 | Exovir, Inc. | Compositions suitable for human topical application including a growth factor and/or related materials |
| US5508031A (en)* | 1986-11-21 | 1996-04-16 | Cetus Oncology Corporation | Method for treating biological damage using a free-radial scavenger and interleukin-2 |
| US4835260A (en)* | 1987-03-20 | 1989-05-30 | Genetics Institute, Inc. | Erythropoietin composition |
| FI885224A7 (en) | 1987-03-23 | 1988-11-11 | Amgen Inc | Purified platelet-derived growth factor and methods for purifying it |
| JP2873012B2 (en)* | 1987-04-09 | 1999-03-24 | デルタ バイオテクノロジー リミテッド | Yeast vector |
| ES2091749T3 (en) | 1987-04-22 | 1996-11-16 | Chiron Corp | PRODUCTION BY RECOMBINATION OF POLYPEPTIDES FROM THE A CHAIN OF THE PLATELET-DERIVED GROWTH FACTOR (FCDP). |
| US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| US4994560A (en) | 1987-06-24 | 1991-02-19 | The Dow Chemical Company | Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies |
| US5489425A (en) | 1987-06-24 | 1996-02-06 | The Dow Chemical Company | Functionalized polyamine chelants |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| AR247761A1 (en) | 1987-07-28 | 1995-03-31 | Gist Brocades Nv | Method for producing a polypeptide in a kluyveromyces host cell, this transformed host cell and the dna sequence used |
| JPH0622784Y2 (en) | 1987-08-04 | 1994-06-15 | 東洋シヤッター株式会社 | Height adjustment device for movable center pillar for over door |
| JP2627899B2 (en) | 1987-08-19 | 1997-07-09 | 株式会社 ビタミン研究所 | Production method of gene-encapsulated liposome |
| SE459586B (en) | 1987-09-14 | 1989-07-17 | Mta Szegedi Biolog Koezponti | THE STRUCTURES CODING FOR AUTHENTIC HUMAN SERUM ALBUMIN AND PROCEDURES FOR ITS PREPARATION |
| US5336603A (en)* | 1987-10-02 | 1994-08-09 | Genentech, Inc. | CD4 adheson variants |
| NZ226414A (en) | 1987-10-02 | 1992-07-28 | Genentech Inc | Cd4 peptide adhesion variants and their preparation and use |
| GB8725529D0 (en)* | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
| JPH0811074B2 (en) | 1987-10-30 | 1996-02-07 | 財団法人化学及血清療法研究所 | Recombinant plasmid incorporating a gene encoding prealbumin and method for producing prealbumin using the same |
| GB8726953D0 (en) | 1987-11-18 | 1987-12-23 | Delta Biotechnology Ltd | Yeast expression system |
| JP2791418B2 (en)* | 1987-12-02 | 1998-08-27 | 株式会社ミドリ十字 | Method for producing heterologous protein, recombinant DNA, transformant |
| US5282856A (en) | 1987-12-22 | 1994-02-01 | Ledergerber Walter J | Implantable prosthetic device |
| ZA89430B (en) | 1988-01-22 | 1989-10-25 | Gen Hospital Corp | Cloned genes encoding ig-cd4 fusion proteins and the use thereof |
| JPH01240191A (en)* | 1988-02-16 | 1989-09-25 | Green Cross Corp:The | A novel signal peptide that functions in yeast and secretory expression of heterologous proteins using it |
| JPH01215289A (en) | 1988-02-22 | 1989-08-29 | Toa Nenryo Kogyo Kk | Production of normal human serum albumin a through gene recombination |
| US4999339A (en)* | 1988-03-28 | 1991-03-12 | Cetus Corporation | Combination therapy of IL-2 and DTIC for the treatment of melanoma |
| US5066489A (en) | 1988-03-28 | 1991-11-19 | Cetus Corporation | Combination therapy of IL-2 and DTIC for the treatment of melanoma |
| US5981485A (en) | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| US5061488A (en) | 1988-04-15 | 1991-10-29 | The United States Of America As Represented Department Of Health & Human Services | Flavone-8-acetic acid and interleukin-2 for cancer therapy |
| US5763394A (en)* | 1988-04-15 | 1998-06-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| US5096885A (en)* | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
| US5096707A (en)* | 1988-04-15 | 1992-03-17 | The United States Of America As Represented By The Department Of Health And Human Services | Flavone-8-acetic acid and interleukin-2 in a method of treating certain cancers |
| GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
| IL89989A0 (en) | 1988-04-25 | 1989-12-15 | Phillips Petroleum Co | Expression of human interleukin-2 in methylotrophic yeasts |
| IL89992A0 (en) | 1988-04-25 | 1989-12-15 | Phillips Petroleum Co | Expression of human serum albumin in methylotrophic yeasts |
| US5126129A (en)* | 1988-05-23 | 1992-06-30 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Cancer therapy using interleukin-2 and flavone compounds |
| ATE101620T1 (en) | 1988-06-23 | 1994-03-15 | Hoechst Ag | MINI-PROINSULIN, ITS PREPARATION AND USE. |
| EP0420942A1 (en) | 1988-06-24 | 1991-04-10 | The Dow Chemical Company | Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates |
| PT90959B (en) | 1988-06-24 | 1995-05-04 | Dow Chemical Co | PROCESS FOR THE PREPARATION OF BIFUNCTIONAL MACROCYCLIC CHELANTES, OF THEIR COMPLEXES AND THEIR CONJUGATES WITH ANTIBODIES |
| US5756065A (en) | 1988-06-24 | 1998-05-26 | The Dow Chemical Company | Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents |
| US5274119A (en) | 1988-07-01 | 1993-12-28 | The Dow Chemical Company | Vicinal diols |
| KR100195632B1 (en) | 1988-07-23 | 1999-06-15 | 스티븐 조지 가랜드 | Peptide and DNA Arrays |
| US4925648A (en) | 1988-07-29 | 1990-05-15 | Immunomedics, Inc. | Detection and treatment of infectious and inflammatory lesions |
| FR2635115B1 (en) | 1988-08-05 | 1992-04-03 | Rhone Poulenc Sante | PROCESS FOR THE PREPARATION OF HUMAN ALBUMIN SERUM FROM YEAST |
| FR2649991B2 (en) | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | USE OF STABLE DERIVATIVES OF PLASMID PKD1 FOR THE EXPRESSION AND SECRETION OF HETEROLOGOUS PROTEINS IN YEASTS OF THE GENUS KLUYVEROMYCES |
| US5601819A (en) | 1988-08-11 | 1997-02-11 | The General Hospital Corporation | Bispecific antibodies for selective immune regulation and for selective immune cell binding |
| AU4216689A (en) | 1988-08-11 | 1990-03-05 | California Biotechnology, Inc. | Method for stabilizing heterologous protein expression and vectors for use therein |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| EP1541682A3 (en) | 1988-09-02 | 2005-07-06 | Dyax Corp. | Generation and selection of recombinant varied binding proteins |
| US5260202A (en) | 1988-09-07 | 1993-11-09 | Delta Biotechnology Limited | Fermentation method |
| JPH02227079A (en) | 1988-10-06 | 1990-09-10 | Tonen Corp | human serum albumin fragment |
| US5298243A (en) | 1988-10-20 | 1994-03-29 | Denki Kagaku Kogyo Kabushiki Kaisha | Colony stimulating factor-gelatin conjugate |
| US5349052A (en) | 1988-10-20 | 1994-09-20 | Royal Free Hospital School Of Medicine | Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor |
| US5759802A (en) | 1988-10-26 | 1998-06-02 | Tonen Corporation | Production of human serum alubumin A |
| JPH02117384A (en) | 1988-10-26 | 1990-05-01 | Tonen Corp | Production of human serum albumin A by yeast hosts |
| WO1990004788A1 (en) | 1988-10-28 | 1990-05-03 | Genentech, Inc. | Method for identifying active domains and amino acid residues in polypeptides and hormone variants |
| US5696239A (en) | 1988-10-31 | 1997-12-09 | The Dow Chemical Company | Conjugates possessing ortho ligating functionality and complexes thereof |
| US5342604A (en) | 1988-10-31 | 1994-08-30 | The Dow Chemical Company | Complexes possessing ortho ligating functionality |
| US5256410A (en) | 1988-12-01 | 1993-10-26 | Schering Corporation | Treatment of squamous cell carcinoma intralesionally with recombinant human alpha interferon |
| US4975271A (en) | 1988-12-19 | 1990-12-04 | Vipont Pharmaceutical, Inc. | Muscosal delivery systems for treatment of periodontal disease |
| DE68925966T2 (en) | 1988-12-22 | 1996-08-29 | Kirin Amgen Inc | CHEMICALLY MODIFIED GRANULOCYTE COLONY EXCITING FACTOR |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| DK105489D0 (en)* | 1989-03-03 | 1989-03-03 | Novo Nordisk As | POLYPEPTIDE |
| US5116964A (en)* | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| US5705363A (en) | 1989-03-02 | 1998-01-06 | The Women's Research Institute | Recombinant production of human interferon τ polypeptides and nucleic acids |
| ATE193541T1 (en) | 1989-03-20 | 2000-06-15 | Gen Hospital Corp | INSULINOTROPIC HORMONE |
| AU5344190A (en) | 1989-03-21 | 1990-10-22 | Vical, Inc. | Expression of exogenous polynucleotide sequences in a vertebrate |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5693622A (en) | 1989-03-21 | 1997-12-02 | Vical Incorporated | Expression of exogenous polynucleotide sequences cardiac muscle of a mammal |
| US5231020A (en) | 1989-03-30 | 1993-07-27 | Dna Plant Technology Corporation | Genetic engineering of novel plant phenotypes |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| ES2034790T3 (en)* | 1989-04-11 | 1993-04-01 | Boehringer Ingelheim International Gmbh | USE OF AT LEAST ONE CITROQUINE FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE SYSTEMATIC TREATMENT OF PRENEOPLASTIC INJURIES. |
| FI901810A7 (en) | 1989-04-13 | 1990-10-14 | Vascular Laboratory Inc | Plasminogen activator complex of pure pro-urokinase bound to human serum albumin via a disulfide bridge |
| US5324844A (en) | 1989-04-19 | 1994-06-28 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| EP0394827A1 (en) | 1989-04-26 | 1990-10-31 | F. Hoffmann-La Roche Ag | Chimaeric CD4-immunoglobulin polypeptides |
| ATE92107T1 (en) | 1989-04-29 | 1993-08-15 | Delta Biotechnology Ltd | N-TERMINAL FRAGMENTS OF HUMAN SERUM ALBUMIN-CONTAINING FUSION PROTEINS. |
| US5766883A (en)* | 1989-04-29 | 1998-06-16 | Delta Biotechnology Limited | Polypeptides |
| GB8909916D0 (en)* | 1989-04-29 | 1989-06-14 | Delta Biotechnology Ltd | Polypeptides |
| US5332671A (en) | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
| WO1990014357A1 (en) | 1989-05-19 | 1990-11-29 | Genentech, Inc. | Her2 extracellular domain |
| EP0399816B1 (en) | 1989-05-24 | 1995-12-20 | Merck & Co. Inc. | Purification and characterization of a glioma-derived growth factor |
| US5808003A (en) | 1989-05-26 | 1998-09-15 | Perimmune Holdings, Inc. | Polyaminocarboxylate chelators |
| DE69021335T2 (en)* | 1989-06-09 | 1996-04-11 | Gropep Pty. Ltd., Adelaide | GROWTH HORMON FUSION PROTEINS. |
| JPH0327320A (en) | 1989-06-26 | 1991-02-05 | Ajinomoto Co Inc | Human b cell differentiation factor pharmaceutical composition |
| ATE144793T1 (en) | 1989-06-29 | 1996-11-15 | Medarex Inc | BISPECIFIC REAGENTS FOR AIDS THERAPY |
| US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| DE3924746A1 (en)* | 1989-07-26 | 1991-01-31 | Behringwerke Ag | ERTHROPOIETIN (EPO) PEPTIDES AND ANTIBODIES THEREFOR |
| FR2650598B1 (en)* | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | DERIVATIVES OF ALBUMIN WITH THERAPEUTIC FUNCTION |
| CU22222A1 (en) | 1989-08-03 | 1995-01-31 | Cigb | PROCEDURE FOR THE EXPRESSION OF HETEROLOGICAL PROTEINS PRODUCED IN A FUSION FORM IN ESCHERICHIA COLI, ITS USE, EXPRESSION VECTORS AND RECOMBINANT STRAINS |
| GB8927480D0 (en) | 1989-12-05 | 1990-02-07 | Delta Biotechnology Ltd | Mutant fungal strain detection and new promoter |
| US5073627A (en) | 1989-08-22 | 1991-12-17 | Immunex Corporation | Fusion proteins comprising GM-CSF and IL-3 |
| WO1991002754A1 (en) | 1989-08-22 | 1991-03-07 | Immunex Corporation | Fusion proteins comprising gm-csf and il-3 |
| US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
| US6063373A (en)* | 1989-09-19 | 2000-05-16 | Maxim Pharmaceuticals, Inc. | Enhanced activation of NK cells using an NK cell activator and a hydrogen peroxide scavenger or inhibitor |
| CA1340994C (en) | 1989-09-21 | 2000-05-16 | Rudolf Edgar Dr. Falk | Treatment of conditions and disease |
| IE66494B1 (en) | 1989-09-26 | 1996-01-10 | Immunex Corp | Granulocyte-colony stimulating factor receptors |
| WO1991005052A1 (en) | 1989-09-28 | 1991-04-18 | Leningradsky Gosudarstvenny Universitet | Method for obtaining a polypeptide with human-interleukin-2 activity, secreted by yeast cells, saccharomyces cerevisiae |
| DE69032483T2 (en) | 1989-10-05 | 1998-11-26 | Optein, Inc., Seattle, Wash. | CELL-FREE SYNTHESIS AND ISOLATION OF GENES AND POLYPEPTIDES |
| FR2653020B1 (en) | 1989-10-17 | 1993-03-26 | Roussel Uclaf | USE OF A POLYPEPTIDE HAVING THE ACTIVITY OF HUMAN INTERLEUKIN 2 FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF LEUKEMIA. |
| US5667986A (en) | 1989-10-18 | 1997-09-16 | Delta Biotechnology Limited | Yeast promoter for expressing heterologous polypeptides |
| GB8924021D0 (en) | 1989-10-25 | 1989-12-13 | Celltech Ltd | Recombinant dna method and vectors for the use therein |
| US5676954A (en) | 1989-11-03 | 1997-10-14 | Vanderbilt University | Method of in vivo delivery of functioning foreign genes |
| JP3056782B2 (en) | 1989-11-03 | 2000-06-26 | ヴァンダービルト ユニバーシティ | Pharmaceutical compositions for expression of genes in target organs |
| US5173408A (en) | 1989-11-13 | 1992-12-22 | Lange Louis George Iii | Mammalian pancreatic cholesterol esterase |
| US5580560A (en)* | 1989-11-13 | 1996-12-03 | Novo Nordisk A/S | Modified factor VII/VIIa |
| DK608589D0 (en) | 1989-12-01 | 1989-12-01 | Holm Arne | CHEMICAL PROCEDURE |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| JPH03201987A (en) | 1989-12-29 | 1991-09-03 | Tonen Corp | human serum albumin fragment |
| US5116944A (en)* | 1989-12-29 | 1992-05-26 | Neorx Corporation | Conjugates having improved characteristics for in vivo administration |
| US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
| WO1991010737A1 (en) | 1990-01-11 | 1991-07-25 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| DK0463151T3 (en) | 1990-01-12 | 1996-07-01 | Cell Genesys Inc | Generation of xenogenic antibodies |
| JP3262329B2 (en) | 1990-01-24 | 2002-03-04 | アイ． バックレイ，ダグラス | GLP-1 analog useful for the treatment of diabetes |
| US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
| DK0439442T3 (en)* | 1990-01-25 | 1996-07-08 | Univ Washington | Factor X-LACI hybrid protein |
| JPH04211375A (en) | 1990-02-05 | 1992-08-03 | Ajinomoto Co Inc | Synthetic gene and production of human serum albumin using the synthetic gene |
| US5747334A (en) | 1990-02-15 | 1998-05-05 | The University Of North Carolina At Chapel Hill | Random peptide library |
| US5208018A (en)* | 1990-03-19 | 1993-05-04 | Brigham And Women's Hospital | Treatment of cachexia with interleukin 2 |
| FR2660863B1 (en)* | 1990-04-17 | 1994-01-21 | Roussel Uclaf | USE OF A POLYPEPTIDE HAVING THE ACTIVITY OF HUMAN INTERLEUKIN 2 FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF PRIMITIVE CANCERS OF THE POWDER. |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| AU7906691A (en) | 1990-05-23 | 1991-12-10 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Adeno-associated virus (aav)-based eucaryotic vectors |
| GB9013017D0 (en) | 1990-06-11 | 1990-08-01 | Mars Uk Ltd | Compounds |
| US5766897A (en)* | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| EP0538300B1 (en) | 1990-07-10 | 1994-04-13 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | O-glycosylated ifn-alpha |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5225341A (en) | 1990-07-19 | 1993-07-06 | The Regents Of The University Of California | Biologically safe plant transformation system using a ds transposon |
| US5202239A (en)* | 1990-08-07 | 1993-04-13 | Scios Nova Inc. | Expression of recombinant polypeptides with improved purification |
| US5071872A (en) | 1990-08-14 | 1991-12-10 | The Ohio State University Research Foundation | Method for improving interleukin-2 activity using aci-reductone compounds |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| KR100272077B1 (en) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | Transgenic non-human animals capable of producing heterologous antibodies |
| US5391183A (en)* | 1990-09-21 | 1995-02-21 | Datascope Investment Corp | Device and method sealing puncture wounds |
| IT1242149B (en) | 1990-09-27 | 1994-02-16 | Consiglio Nazionale Ricerche | CODING NUCLEOTID SEQUENCE FOR A HUMAN PROTEIN WITH REGULATORY PROPERTIES OF ANGIOGENESIS |
| US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
| CA2093022C (en) | 1990-10-05 | 2005-02-22 | Michael W. Fanger | Targeted immunostimulation with bispecific reagents |
| JPH07108232B2 (en) | 1990-10-09 | 1995-11-22 | エム・ディ・リサーチ株式会社 | Method for producing peptide or protein |
| JPH0638771Y2 (en) | 1990-10-26 | 1994-10-12 | 株式会社カンセイ | Airbag control device |
| EP0557300B1 (en) | 1990-10-29 | 1997-11-19 | Chiron Corporation | Bispecific antibodies, method of production, and uses thereof |
| FR2668368B1 (en) | 1990-10-30 | 1995-03-10 | Roussel Uclaf | USE OF A POLYPEPTIDE HAVING THE ACTIVITY OF HUMAN INTERLEUKIN 2 FOR PREPARING A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF MALIGNANT EPITHELIAL TUMORS. |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| JPH0638771A (en) | 1990-10-31 | 1994-02-15 | Tonen Corp | Method for expressing human protein disulfide isomerase gene and method for producing polypeptide by co-expression with the gene |
| US5353535A (en) | 1990-11-05 | 1994-10-11 | Plumly George W | Floor type advertising apparatus |
| US5830452A (en) | 1990-11-20 | 1998-11-03 | Chiron Corporation | Method for enhancing the anti-tumor therapeutic index of interleukin-2 |
| WO1992009691A1 (en) | 1990-11-29 | 1992-06-11 | Institut National De La Recherche Agronomique - I.N.R.A. | New variants derived from interferons of type i, production process thereof and their applications |
| ES2113940T3 (en) | 1990-12-03 | 1998-05-16 | Genentech Inc | ENRICHMENT METHOD FOR PROTEIN VARIANTS WITH ALTERED UNION PROPERTIES. |
| US5272080A (en)* | 1991-02-19 | 1993-12-21 | Pharmavene, Inc. | Production of butyrylcholinesterase |
| WO1994027631A1 (en)* | 1993-05-21 | 1994-12-08 | Zymogenetics, Inc. | Modified factor vii |
| US5833982A (en) | 1991-02-28 | 1998-11-10 | Zymogenetics, Inc. | Modified factor VII |
| US5272070A (en)* | 1991-03-08 | 1993-12-21 | Board Of Regents, The University Of Texas System | Method for the preparation of cell lines producing Man3 GlcNac 2 asparagine-linked gylcans and cell lines produced thereby |
| CA2062659A1 (en) | 1991-03-12 | 1992-09-13 | Yasutaka Igari | Composition for sustained-release of erythropoietin |
| US5817471A (en) | 1991-03-14 | 1998-10-06 | The United States Of America As Represented By The Department Of Health And Human Services | Trk tyrosine kinase receptor is the physiological receptor for nerve growth factor |
| CA2064331C (en) | 1991-03-28 | 2003-02-18 | Marvin L. Bayne | Vascular endothelial cell growth factor c subunit |
| DE69233750D1 (en) | 1991-04-10 | 2009-01-02 | Scripps Research Inst | Libraries of heterodimeric receptors using phagemids |
| US5374617A (en) | 1992-05-13 | 1994-12-20 | Oklahoma Medical Research Foundation | Treatment of bleeding with modified tissue factor in combination with FVIIa |
| EP0509841A3 (en) | 1991-04-18 | 1993-08-18 | Tonen Corporation | Co-expression system of protein disulfide isomerase gene and useful polypeptide gene and process for producing the polypeptide using its system |
| CA2058820C (en) | 1991-04-25 | 2003-07-15 | Kotikanyad Sreekrishna | Expression cassettes and vectors for the secretion of human serum albumin in pichia pastoris cells |
| US5330901A (en) | 1991-04-26 | 1994-07-19 | Research Corporation Technologies, Inc. | Expression of human serum albumin in Pichia pastoris |
| ES2093778T3 (en) | 1991-04-26 | 1997-01-01 | Surface Active Ltd | NEW ANTIBODIES AND METHODS FOR USE. |
| FR2676070B1 (en) | 1991-04-30 | 1994-09-30 | Rhone Poulenc Rorer Sa | YEAST PROMOTER AND ITS USE. |
| US5646012A (en)* | 1991-04-30 | 1997-07-08 | Rhone-Poulenc Rorer S.A. | Yeast promoter and use thereof |
| DE69233482T2 (en) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Method for reducing the immunogenicity of antibody variable domains |
| IL101943A0 (en) | 1991-05-24 | 1992-12-30 | Genentech Inc | Structure,production and use of heregulin |
| US5304473A (en)* | 1991-06-11 | 1994-04-19 | Eli Lilly And Company | A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production |
| WO1992022324A1 (en) | 1991-06-14 | 1992-12-23 | Xoma Corporation | Microbially-produced antibody fragments and their conjugates |
| FR2677996B1 (en) | 1991-06-21 | 1993-08-27 | Rhone Poulenc Rorer Sa | CLONING AND / OR EXPRESSION VECTORS PREPARATION AND USE. |
| US5844095A (en)* | 1991-06-27 | 1998-12-01 | Bristol-Myers Squibb Company | CTLA4 Ig fusion proteins |
| US5851795A (en)* | 1991-06-27 | 1998-12-22 | Bristol-Myers Squibb Company | Soluble CTLA4 molecules and uses thereof |
| AU2147192A (en) | 1991-06-28 | 1993-01-25 | Genentech Inc. | Method of stimulating immune response using growth hormone |
| US5223408A (en)* | 1991-07-11 | 1993-06-29 | Genentech, Inc. | Method for making variant secreted proteins with altered properties |
| JPH05292972A (en) | 1991-07-29 | 1993-11-09 | Tonen Corp | Improved yeast expression system |
| EP0597010A4 (en) | 1991-07-31 | 1996-12-27 | Rhone Poulenc Rorer Int | Transgenic protein production. |
| US5723719A (en) | 1991-08-08 | 1998-03-03 | Health Research Inc. | Transgenic mouse as model for diseases involving dopaminergic dysfunction |
| DE4126968A1 (en) | 1991-08-14 | 1993-02-18 | Detlev Prof Dr Med Ganten | Transgenic rats that contain at least one human gene in their genome that is involved in blood pressure regulation |
| ES2136092T3 (en) | 1991-09-23 | 1999-11-16 | Medical Res Council | PROCEDURES FOR THE PRODUCTION OF HUMANIZED ANTIBODIES. |
| US6270989B1 (en) | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
| NZ245015A (en)* | 1991-11-05 | 1995-12-21 | Transkaryotic Therapies Inc | Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| WO1993008842A1 (en)* | 1991-11-08 | 1993-05-13 | Somatogen, Inc. | Hemoglobins as drug delivery agents |
| US5786883A (en)* | 1991-11-12 | 1998-07-28 | Pilkington Barnes Hind, Inc. | Annular mask contact lenses |
| ES2227512T3 (en) | 1991-12-02 | 2005-04-01 | Medical Research Council | PRODUCTION OF ANTIBODIES AGAINST SELF-ANTIGENS FROM REPERTORIES OF ANTIBODY SEGMENTS FIXED IN A PHOTO. |
| US6348327B1 (en)* | 1991-12-06 | 2002-02-19 | Genentech, Inc. | Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells |
| US5540923A (en)* | 1991-12-06 | 1996-07-30 | Landsforeningen Til Kraeftens Bekaemplse | Interferon proteins |
| US5428139A (en) | 1991-12-10 | 1995-06-27 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals |
| WO1993014200A1 (en) | 1992-01-07 | 1993-07-22 | Tsi Corporation | Transgenic animal models for alzheimer's disease |
| GB9200417D0 (en) | 1992-01-09 | 1992-02-26 | Bagshawe Kenneth D | Cytotoxic drug therapy |
| FR2686620B1 (en)* | 1992-01-27 | 1995-06-23 | Rhone Poulenc Rorer Sa | HUMAN SERUM-ALBUMIN, PREPARATION AND USE. |
| FR2686900B1 (en) | 1992-01-31 | 1995-07-21 | Rhone Poulenc Rorer Sa | NOVEL POLYPEPTIDES HAVING GRANULOCYTE COLONY STIMULATION ACTIVITY, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| FR2686899B1 (en)* | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| FR2686901A1 (en) | 1992-01-31 | 1993-08-06 | Rhone Poulenc Rorer Sa | NOVEL ANTITHROMBOTIC POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| EP0625200B1 (en) | 1992-02-06 | 2005-05-11 | Chiron Corporation | Biosynthetic binding protein for cancer marker |
| ATE239506T1 (en) | 1992-03-05 | 2003-05-15 | Univ Texas | USE OF IMMUNOCONJUGATES FOR THE DIAGNOSIS AND/OR THERAPY OF VASCULARIZED TUMORS |
| US5230886A (en) | 1992-03-18 | 1993-07-27 | Trustees Of Boston University | Tumor cell suppression |
| DK36492D0 (en) | 1992-03-19 | 1992-03-19 | Novo Nordisk As | PREPARATION |
| USRE37302E1 (en) | 1992-03-19 | 2001-07-31 | Novo Nordisk A/S | Peptide |
| DK36392D0 (en)* | 1992-03-19 | 1992-03-19 | Novo Nordisk As | USE OF CHEMICAL COMPOUND |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5460954A (en) | 1992-04-01 | 1995-10-24 | Cheil Foods & Chemicals, Inc. | Production of human proinsulin using a novel vector system |
| US5229109A (en) | 1992-04-14 | 1993-07-20 | Board Of Regents, The University Of Texas System | Low toxicity interleukin-2 analogues for use in immunotherapy |
| JPH06105020B2 (en) | 1992-06-09 | 1994-12-21 | ホッペ・アーゲー | Latch and lockup system |
| PL176007B1 (en) | 1992-06-15 | 1999-03-31 | Scios Inc | Novel derivatives of polypeptide glp-1 |
| US5686268A (en)* | 1992-06-19 | 1997-11-11 | Pfizer Inc. | Fused proteins |
| US5505931A (en) | 1993-03-04 | 1996-04-09 | The Dow Chemical Company | Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents |
| JP3269504B2 (en) | 1992-07-08 | 2002-03-25 | 三菱ウェルファーマ株式会社 | Method for producing human serum albumin |
| FR2694294B1 (en)* | 1992-07-30 | 1994-09-09 | Rhone Poulenc Rorer Sa | Yeast promoter and its user. |
| AU686567C (en) | 1992-07-31 | 2002-08-08 | Genentech Inc. | Human growth hormone aqueous formulation |
| US5602307A (en) | 1992-08-12 | 1997-02-11 | Baylor College Of Medicine | Non-human animal having predefined allele of a cellular adhesion gene |
| DE4226971C2 (en) | 1992-08-14 | 1997-01-16 | Widmar Prof Dr Tanner | Modified fungal cells and processes for the production of recombinant products |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US5728553A (en)* | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
| US5731490A (en) | 1992-09-29 | 1998-03-24 | The Ontario Cancer Institute | Mutant mouse lacking the expression of interferon regulatory factor 1 (IRF-1) |
| WO1994008599A1 (en)* | 1992-10-14 | 1994-04-28 | The Regents Of The University Of Colorado | Ion-pairing of drugs for improved efficacy and delivery |
| FR2697752B1 (en)* | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Antitumor compositions containing taxane derivatives. |
| TW402639B (en) | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
| US5478745A (en) | 1992-12-04 | 1995-12-26 | University Of Pittsburgh | Recombinant viral vector system |
| US5441050A (en) | 1992-12-18 | 1995-08-15 | Neoprobe Corporation | Radiation responsive surgical instrument |
| US6221958B1 (en)* | 1993-01-06 | 2001-04-24 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
| US5489743A (en) | 1993-01-19 | 1996-02-06 | Amgen Inc. | Transgenic animal models for thrombocytopenia |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| FR2701953B1 (en) | 1993-02-22 | 1995-05-24 | Centre Nat Rech Scient | Multi-VIP fusion protein and method for preparing recombinant VIP. |
| US5441734A (en) | 1993-02-25 | 1995-08-15 | Schering Corporation | Metal-interferon-alpha crystals |
| US5780021A (en) | 1993-03-05 | 1998-07-14 | Georgetown University | Method for treating type 1 diabetes using α-interferon and/or β-i |
| US5869445A (en) | 1993-03-17 | 1999-02-09 | University Of Washington | Methods for eliciting or enhancing reactivity to HER-2/neu protein |
| NZ250844A (en) | 1993-04-07 | 1996-03-26 | Pfizer | Treatment of non-insulin dependant diabetes with peptides; composition |
| US6284727B1 (en) | 1993-04-07 | 2001-09-04 | Scios, Inc. | Prolonged delivery of peptides |
| AU6709794A (en) | 1993-04-21 | 1994-11-08 | Brigham And Women's Hospital | Erythropoietin muteins with enhanced activity |
| GB9308581D0 (en) | 1993-04-26 | 1993-06-09 | Univ Manitoba | A method for induction of antigen-specific suppression of immune-response |
| EP0702722B1 (en) | 1993-06-07 | 2005-08-03 | Vical Incorporated | Plasmids suitable for gene therapy |
| US5621039A (en)* | 1993-06-08 | 1997-04-15 | Hallahan; Terrence W. | Factor IX- polymeric conjugates |
| DK82893D0 (en)* | 1993-07-08 | 1993-07-08 | Novo Nordisk As | PEPTIDE |
| US5512459A (en) | 1993-07-20 | 1996-04-30 | Bionebraska, Inc. | Enzymatic method for modification or recombinant polypeptides |
| JPH09501174A (en) | 1993-08-09 | 1997-02-04 | バラル、エドワード | A method for sensitizing cancer cells to killer cell-mediated cytolysis |
| IL110669A (en) | 1993-08-17 | 2008-11-26 | Kirin Amgen Inc | Erythropoietin analogs |
| GB9317618D0 (en) | 1993-08-24 | 1993-10-06 | Royal Free Hosp School Med | Polymer modifications |
| AU7531094A (en) | 1993-08-24 | 1995-03-21 | Novo Nordisk A/S | Protracted glp-1 |
| US5521086A (en)* | 1993-09-16 | 1996-05-28 | Cephalon, Inc. | Secretion sequence for the production of a heterologous protein in yeast |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5459031A (en) | 1993-11-05 | 1995-10-17 | Amgen Inc. | Methods for controlling sialic acid derivatives in recombinant glycoproteins |
| AU696293B2 (en) | 1993-12-08 | 1998-09-03 | Genzyme Corporation | Process for generating specific antibodies |
| EP0658568A1 (en) | 1993-12-09 | 1995-06-21 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| WO1995016708A1 (en) | 1993-12-17 | 1995-06-22 | Novo Nordisk A/S | Proinsulin-like compounds |
| DK144093D0 (en) | 1993-12-23 | 1993-12-23 | Novo Nordisk As | |
| ATE300610T1 (en) | 1994-01-31 | 2005-08-15 | Univ Boston | LIBRARIES OF POLYCLONAL ANTIBODIES |
| US5550214A (en) | 1994-02-10 | 1996-08-27 | Brigham And Women's Hospital | Isolated antigenic oncogene peptide fragments and uses |
| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US5834252A (en) | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
| US5932780A (en) | 1994-02-28 | 1999-08-03 | Yissum Research Development Company Of Hebrew University Of Jerusalem | Transgenic non-human animal assay system for anti-cholinesterase substances |
| GB9404270D0 (en) | 1994-03-05 | 1994-04-20 | Delta Biotechnology Ltd | Yeast strains and modified albumins |
| US6608182B1 (en) | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
| US5652352A (en) | 1994-03-31 | 1997-07-29 | Amgen Inc. | Afamin: a human serum albumin-like gene |
| US5629286A (en)* | 1994-03-31 | 1997-05-13 | Brewitt; Barbara | Homeopathic dilutions of growth factors |
| US5646113A (en) | 1994-04-07 | 1997-07-08 | Genentech, Inc. | Treatment of partial growth hormone insensitivity syndrome |
| FR2719593B1 (en) | 1994-05-06 | 1996-05-31 | Rhone Poulenc Rorer Sa | New biologically active polypeptides, their preparation and pharmaceutical composition containing them. |
| GB9409496D0 (en) | 1994-05-12 | 1994-06-29 | London Health Ass | Method for improving glycaemic control in diabetes |
| GB9411356D0 (en) | 1994-06-07 | 1994-07-27 | Delta Biotechnology Ltd | Yeast strains |
| US5516637A (en) | 1994-06-10 | 1996-05-14 | Dade International Inc. | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
| US5985660A (en) | 1994-06-15 | 1999-11-16 | Systemix, Inc. | Method of identifying biological response modifiers involved in dendritic and/or lymphoid progenitor cell proliferation and/or differentiation |
| US5639642A (en)* | 1994-06-16 | 1997-06-17 | Novo Nordisk A/S | Synthetic leader peptide sequences |
| US5623054A (en) | 1994-06-23 | 1997-04-22 | The General Hospital Corporation | Crucifer AFT proteins and uses thereof |
| EP0769963A4 (en) | 1994-07-27 | 1999-07-28 | Commw Scient Ind Res Org | Polyepitope vaccines |
| JPH0851982A (en) | 1994-08-11 | 1996-02-27 | Asahi Glass Co Ltd | Modified gene encoding human serum albumin |
| JPH0853500A (en) | 1994-08-11 | 1996-02-27 | Asahi Glass Co Ltd | Fusion protein and gene encoding the protein |
| JPH0859509A (en) | 1994-08-16 | 1996-03-05 | Teijin Ltd | Agent for treating cytomegalovirus antigenemia and agent for treating cytomegalovirus infectious disease |
| US5574008A (en) | 1994-08-30 | 1996-11-12 | Eli Lilly And Company | Biologically active fragments of glucagon-like insulinotropic peptide |
| US6071923A (en)* | 1994-09-16 | 2000-06-06 | Bar-Ilan University | Retinoyloxy aryl-substituted alkylene butyrates useful for the treatment of cancer and other proliferative diseases |
| US5512549A (en)* | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
| FR2726471B1 (en)* | 1994-11-07 | 1997-01-31 | Pf Medicament | PROCESS FOR IMPROVING THE IMMUNOGENICITY OF AN IMMUNOGENIC COMPOUND OR A HAPTENA AND APPLICATION TO THE PREPARATION OF VACCINES |
| DE69434988T2 (en) | 1994-11-07 | 2008-03-06 | Human Genome Sciences, Inc. | Tumor necrosis FACTOR GAMMA |
| FR2726576B1 (en) | 1994-11-07 | 1997-01-31 | Pf Medicament | PRODUCTION OF HYDROPHOBIC PEPTIDE-LIKE PEPTIDES, RECOMBINANT PEPTIDE, CORRESPONDING DNA SEQUENCE |
| AT403167B (en)* | 1994-11-14 | 1997-11-25 | Immuno Ag | SELECTION AND EXPRESSION OF FOREIGN PROTEINS BY MEANS OF A SELECTION-AMPLIFICATION SYSTEM |
| US5695750A (en) | 1994-11-25 | 1997-12-09 | The United States Of America As Represented By The Secretary Of The Army | Compositions for use to deactivate organophosphates |
| WO1996017941A2 (en) | 1994-12-07 | 1996-06-13 | Bionebraska, Inc. | Production of c-terminal amidated peptides from recombinant protein constructs |
| CA2206848A1 (en) | 1994-12-07 | 1996-06-13 | Bionebraska, Inc. | Production of peptides using recombinant fusion protein constructs |
| DE69534265T2 (en)* | 1994-12-12 | 2006-05-04 | Beth Israel Deaconess Medical Center, Inc., Boston | CHIMERIC CYTOKINS AND ITS USE |
| US20010006943A1 (en) | 1994-12-23 | 2001-07-05 | Ejvind Jensen | Protracted GLP-1 compositions |
| AU4298596A (en) | 1994-12-23 | 1996-07-19 | Novo Nordisk A/S | Protracted glp-1 compositions |
| US5583415A (en) | 1994-12-27 | 1996-12-10 | Motorola, Inc. | Apparatus for simulating high battery temperature for rechargeble battery systems |
| US5652224A (en) | 1995-02-24 | 1997-07-29 | The Trustees Of The University Of Pennsylvania | Methods and compositions for gene therapy for the treatment of defects in lipoprotein metabolism |
| US5928939A (en) | 1995-03-01 | 1999-07-27 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-b and dna coding therefor |
| US5837281A (en)* | 1995-03-17 | 1998-11-17 | Takeda Chemical Industries, Ltd. | Stabilized interface for iontophoresis |
| JP2758154B2 (en) | 1995-04-06 | 1998-05-28 | エフ・ホフマン−ラ ロシユ アーゲー | Liquid preparations containing interferon |
| US6184201B1 (en) | 1995-04-14 | 2001-02-06 | Nps Allelix Corp. | Intestinotrophic glucagon-like peptide-2 analogs |
| ATE390933T1 (en) | 1995-04-27 | 2008-04-15 | Amgen Fremont Inc | HUMAN ANTIBODIES AGAINST IL-8 DERIVED FROM IMMUNIZED XENOMICES |
| EP2017337A1 (en) | 1995-04-27 | 2009-01-21 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptors |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5480640A (en) | 1995-05-02 | 1996-01-02 | Schering Corporation | Alpha interferon for treating prostate cancer |
| AU3134695A (en) | 1995-05-05 | 1996-11-21 | Human Genome Sciences, Inc. | Human chemokine beta-8, chemokine beta-1 and macrophage infl ammatory protein-4 |
| EP0741188A3 (en) | 1995-05-05 | 1999-07-14 | Eli Lilly And Company | Single chain insulin with high bioactivity |
| US5728915A (en) | 1995-05-08 | 1998-03-17 | Children's Hospital, Inc. | Transgenic mice which express simian SV 40 T-antigen under control of the retinoblastoma gene promoter |
| US5705151A (en) | 1995-05-18 | 1998-01-06 | National Jewish Center For Immunology & Respiratory Medicine | Gene therapy for T cell regulation |
| US6001625A (en) | 1995-05-19 | 1999-12-14 | The United States Of America As Represented By The Secretary Of The Army | Site-directed mutagenesis of esterases |
| US6387365B1 (en)* | 1995-05-19 | 2002-05-14 | Schering Corporation | Combination therapy for chronic hepatitis C infection |
| US5741815A (en) | 1995-06-02 | 1998-04-21 | Lai; Ching-San | Methods for in vivo reduction of nitric oxide levels and compositions useful therefor |
| US5804162A (en) | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
| US5728707A (en)* | 1995-07-21 | 1998-03-17 | Constantia Gruppe | Treatment and prevention of primary and metastatic neoplasms with salts of aminoimidazole carboxamide |
| US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| US5840542A (en) | 1995-07-28 | 1998-11-24 | Mogam Biotechnology Research Institute | Method for manufacture of proinsulin with high export yield |
| DE19530865A1 (en) | 1995-08-22 | 1997-02-27 | Michael Dr Med Nauck | Active ingredient and agent for parenteral nutrition |
| JPH0995455A (en) | 1995-09-29 | 1997-04-08 | Sumitomo Pharmaceut Co Ltd | Renal function improving agent |
| US5849322A (en) | 1995-10-23 | 1998-12-15 | Theratech, Inc. | Compositions and methods for buccal delivery of pharmaceutical agents |
| US5766620A (en) | 1995-10-23 | 1998-06-16 | Theratech, Inc. | Buccal delivery of glucagon-like insulinotropic peptides |
| US5702717A (en) | 1995-10-25 | 1997-12-30 | Macromed, Inc. | Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers |
| CA2236591C (en) | 1995-11-02 | 2012-01-03 | Schering Corporation | Continuous low-dose cytokine infusion therapy |
| US6048964A (en)* | 1995-12-12 | 2000-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
| US6080409A (en) | 1995-12-28 | 2000-06-27 | Dendreon Corporation | Immunostimulatory method |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| US6110707A (en) | 1996-01-19 | 2000-08-29 | Board Of Regents, The University Of Texas System | Recombinant expression of proteins from secretory cell lines |
| US6087129A (en) | 1996-01-19 | 2000-07-11 | Betagene, Inc. | Recombinant expression of proteins from secretory cell lines |
| CA2246431A1 (en) | 1996-01-19 | 1997-07-24 | Board Of Regents, The University Of Texas System | Recombinant expression of proteins from secretory cell lines |
| US6150337A (en) | 1996-01-23 | 2000-11-21 | Icn Pharmaceuticals, Inc. | Specific modulation of Th1/Th2 cytokine expression by Ribavirin in activated T-lymphocytes |
| US5767097A (en)* | 1996-01-23 | 1998-06-16 | Icn Pharmaceuticals, Inc. | Specific modulation of Th1/Th2 cytokine expression by ribavirin in activated T-lymphocytes |
| JP2978435B2 (en) | 1996-01-24 | 1999-11-15 | チッソ株式会社 | Method for producing acryloxypropyl silane |
| US5616724A (en) | 1996-02-21 | 1997-04-01 | Cephalon, Inc. | Fused pyrrolo[2,3-c]carbazole-6-ones |
| DE19639601A1 (en) | 1996-02-28 | 1997-09-04 | Bayer Ag | Parapox viruses that contain foreign DNA, their production and their use in vaccines |
| US6045788A (en)* | 1996-02-28 | 2000-04-04 | Cornell Research Foundation, Inc. | Method of stimulation of immune response with low doses of IL-2 |
| US5912229A (en)* | 1996-03-01 | 1999-06-15 | Novo Nordisk Als | Use of a pharmaceutical composition comprising an appetite-suppressing peptide |
| JP4064460B2 (en) | 1996-03-01 | 2008-03-19 | ノボ ノルディスク アクティーゼルスカブ | Use of a pharmaceutical composition comprising an appetite suppressive peptide |
| JP3794748B2 (en)* | 1996-03-04 | 2006-07-12 | 第一アスビオファーマ株式会社 | Method for culturing microorganisms with methanol metabolism |
| WO1997033904A1 (en) | 1996-03-12 | 1997-09-18 | Human Genome Sciences, Inc. | Death domain containing receptors |
| ATE241695T1 (en) | 1996-03-13 | 2003-06-15 | Delta Biotechnology Ltd | FERMENTATION CONTROL SYSTEMS |
| WO1997033899A1 (en) | 1996-03-14 | 1997-09-18 | Human Genome Sciences, Inc. | Apoptosis inducing molecule i |
| JP2000506865A (en) | 1996-03-14 | 2000-06-06 | ジ イミューン リスポンス コーポレイション | Targeted delivery of genes encoding interferons |
| WO1997034997A1 (en) | 1996-03-21 | 1997-09-25 | Human Genome Sciences, Inc. | Human endometrial specific steroid-binding factor i, ii and iii |
| EP0904278A4 (en) | 1996-03-22 | 1999-09-15 | Human Genome Sciences Inc | Apoptosis inducing molecule ii |
| US6204022B1 (en)* | 1996-04-12 | 2001-03-20 | Pepgen Corporation And University Of Florida | Low-toxicity human interferon-alpha analogs |
| WO1997039132A1 (en) | 1996-04-16 | 1997-10-23 | University Of Miami | Stabilized preparations of human troponins and modifications thereof, diagnostic assay methods and assay kits |
| EP0966971A1 (en)* | 1996-04-23 | 1999-12-29 | Chugai Seiyaku Kabushiki Kaisha | Cerebral stroke/cerebral edema preventive or remedy containing il-8 binding inhibitor as active ingredient |
| CA2255615C (en)* | 1996-05-22 | 2006-08-29 | Neuromedica, Inc. | Compositions comprising conjugates of cis-docosahexaenoic acid and docetaxel |
| US5919815A (en) | 1996-05-22 | 1999-07-06 | Neuromedica, Inc. | Taxane compounds and compositions |
| US6300065B1 (en) | 1996-05-31 | 2001-10-09 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| JP3553970B2 (en)* | 1996-06-11 | 2004-08-11 | ロシュ ダイアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | Recombinant blood coagulation protease |
| US6110891A (en) | 1996-06-21 | 2000-08-29 | Alizyme Therapeutics Ltd. | Lectin compositions and uses thereof |
| GB2318352A (en) | 1996-06-25 | 1998-04-22 | Dejan Markovic | Polypeptides mimicking the activity of human erythropoietin |
| GB9613858D0 (en) | 1996-07-02 | 1996-09-04 | Cortecs Ltd | Hydrophobic preparations |
| US5932547A (en) | 1996-07-03 | 1999-08-03 | Alza Corporation | Non-aqueous polar aprotic peptide formulations |
| US6110703A (en) | 1996-07-05 | 2000-08-29 | Novo Nordisk A/S | Method for the production of polypeptides |
| US6828426B1 (en) | 1996-07-15 | 2004-12-07 | Chugai Seiyaku Kabushiki Kaisha | VEGF-like factor |
| PE99498A1 (en) | 1996-07-26 | 1999-01-21 | Novartis Ag | FUSION POLYPEPTIDES |
| WO1998005782A1 (en) | 1996-08-02 | 1998-02-12 | Zymogenetics, Inc. | Testis-specific insulin homolog polypeptides |
| US6190533B1 (en) | 1996-08-15 | 2001-02-20 | Exxon Chemical Patents Inc. | Integrated hydrotreating steam cracking process for the production of olefins |
| AU731123B2 (en) | 1996-08-16 | 2001-03-22 | Human Genome Sciences, Inc. | Human endokine alpha |
| EP0920505B1 (en) | 1996-08-16 | 2008-06-04 | Schering Corporation | Mammalian cell surface antigens; related reagents |
| ES2251740T3 (en) | 1996-08-23 | 2006-05-01 | Ludwig Institute For Cancer Research | GROWTH FACTOR OF VASCULAR D RECOMBINANT ENDOTHELIAL CELLS (VEGF-D). |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6277819B1 (en) | 1996-08-30 | 2001-08-21 | Eli Lilly And Company | Use of GLP-1 or analogs in treatment of myocardial infarction |
| US6006753A (en) | 1996-08-30 | 1999-12-28 | Eli Lilly And Company | Use of GLP-1 or analogs to abolish catabolic changes after surgery |
| US5922761A (en) | 1996-09-06 | 1999-07-13 | Medinox, Inc. | Methods for in vivo reduction of iron levels and compositions useful therefor |
| WO1998011136A1 (en) | 1996-09-09 | 1998-03-19 | Novo Nordisk A/S | A cDNA AND PEPTIDE WITH RELATION TO CANCER AND WEIGHT LOSS |
| US20020052309A1 (en) | 1996-09-11 | 2002-05-02 | Athanasius A. Anagnostou | Method of treating endothelial injury |
| EP0961832A4 (en)* | 1996-09-18 | 2003-02-26 | Human Genome Sciences Inc | Human tumor necrosis factor receptor-like genes |
| US6225290B1 (en) | 1996-09-19 | 2001-05-01 | The Regents Of The University Of California | Systemic gene therapy by intestinal cell transformation |
| US5994112A (en) | 1996-10-09 | 1999-11-30 | Incyte Pharmaceuticals, Inc. | Human protein tyrosine kinase |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| US5955508A (en)* | 1996-10-15 | 1999-09-21 | Loyola University Of Chicago | Method for the enhancement of lymphocyte activity against opportunistic microbial pathogens |
| NZ519191A (en) | 1996-10-18 | 2005-04-29 | Univ Texas | Antibodies that bind to domain 1 of ErbB2 useful for inducing cell death via apoptosis, and nucleic acids encoding such antibodies |
| WO1998017281A1 (en) | 1996-10-24 | 1998-04-30 | Vion Pharmaceuticals, Inc. | MONOPHOSPHATE PRODRUGS OF β-L-FD4C AND β-L-FddC AS POTENT ANTIVIRAL AGENTS |
| DE69635088T3 (en) | 1996-10-25 | 2012-01-26 | Human Genome Sciences, Inc. | NEUTROKIN alpha |
| JPH10134761A (en) | 1996-10-30 | 1998-05-22 | Ebara Corp | Ion implantation device and method |
| US5908830A (en)* | 1996-10-31 | 1999-06-01 | Merck & Co., Inc. | Combination therapy for the treatment of diabetes and obesity |
| UA65549C2 (en)* | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Use of glucagon-like peptides such as glp-1, glp-1 analog, or glp-1 derivative in methods and compositions for reducing body weight |
| EP1306092A3 (en) | 1996-11-05 | 2003-05-07 | Eli Lilly & Company | Use of GLP-1 and analogs administered peripherally, in regulation of obesity |
| GB9623205D0 (en)* | 1996-11-07 | 1997-01-08 | Eurand Int | Novel pharmaceutical compositions |
| WO1998020895A1 (en) | 1996-11-12 | 1998-05-22 | Novo Nordisk A/S | Use of glp-1 peptides |
| KR100643058B1 (en) | 1996-12-03 | 2006-11-13 | 아브게닉스, 인크. | Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom |
| US6130248A (en) | 1996-12-30 | 2000-10-10 | Bar-Ilan University | Tricarboxylic acid-containing oxyalkyl esters and uses thereof |
| US5833994A (en) | 1997-01-08 | 1998-11-10 | Paracelsian, Inc. | Use of the AH receptor and AH receptor ligands to treat or prevent cytopathicity of viral infection |
| US6261801B1 (en) | 1997-01-14 | 2001-07-17 | Human Genome Sceineces, Inc. | Nucleic acids encoding tumor necrosis factor receptor 5 |
| AU5549998A (en)* | 1997-01-24 | 1998-08-18 | Novo Nordisk A/S | Synthetic leader peptide sequences |
| PT1012274E (en) | 1997-01-28 | 2007-08-14 | Craig A Rosen | Death domain containing receptor 4 (dr4: death receptor 4), member of the tnf-receptor superfamily and binding to trail (ap0-2l) |
| DE69800640T2 (en) | 1997-01-29 | 2001-07-05 | Polymasc Pharmaceuticals Plc, London | PEGYLATION PROCEDURE |
| JP2001512318A (en) | 1997-02-13 | 2001-08-21 | アプライド フィトロジックス，インコーポレイテッド | Production of mature proteins in plants |
| GB2324529A (en) | 1997-02-21 | 1998-10-28 | Merck & Co Inc | A combinatorial library based on a tetrapeptide substituted with aminomethylcoumarin for characterizing proteases |
| US7026447B2 (en)* | 1997-10-09 | 2006-04-11 | Human Genome Sciences, Inc. | 53 human secreted proteins |
| US6030961A (en)* | 1997-03-11 | 2000-02-29 | Bar-Ilan Research & Development Co., Ltd. | Oxyalkylene phosphate compounds and uses thereof |
| US6110970A (en) | 1997-03-11 | 2000-08-29 | Beacon Laboratories, Inc. | Nitrogen-containing oxyalkylene esters and uses thereof |
| US5939455A (en) | 1997-03-11 | 1999-08-17 | Beacon Laboratories, Inc. | Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives |
| US6110955A (en) | 1997-03-11 | 2000-08-29 | Beacon Laboratories, Inc. | Metabolically stabilized oxyalkylene esters and uses thereof |
| US6124495A (en) | 1997-03-11 | 2000-09-26 | Beacon Laboratories, Inc. | Unsaturated oxyalkylene esters and uses thereof |
| US5846774A (en) | 1997-03-21 | 1998-12-08 | Bionebraska, Inc. | Chlorella virus promoters |
| US5981488A (en) | 1997-03-31 | 1999-11-09 | Eli Lillly And Company | Glucagon-like peptide-1 analogs |
| TR199902553T2 (en) | 1997-04-14 | 2000-03-21 | Micromet Gesellschaft F�R Biomedizinische Forschung Mbh | New methods and uses for the production of antigen receptors against the human body. |
| MY118835A (en) | 1997-04-18 | 2005-01-31 | Ipsen Pharma Biotech | Sustained release compositions and the process for their preparation |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| WO1998050347A1 (en) | 1997-05-05 | 1998-11-12 | The Regents Of The University Of California | Naphthols useful in antiviral methods |
| EP1003767A4 (en) | 1997-05-30 | 2003-01-02 | Human Genome Sciences Inc | Human tumor necrosis factor receptor tr10 |
| US6071743A (en) | 1997-06-02 | 2000-06-06 | Subsidiary No. 3, Inc. | Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes |
| WO1998056892A1 (en) | 1997-06-11 | 1998-12-17 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor tr9 |
| GB9713412D0 (en) | 1997-06-26 | 1997-08-27 | Delta Biotechnology Ltd | Improved protein expression strains |
| US5858719A (en) | 1997-07-17 | 1999-01-12 | Incyte Pharmaceuticals, Inc. | Polynucleotides encoding human ATP binding-cassette transport protein and methods of use |
| DE69726571T2 (en) | 1997-09-01 | 2004-11-04 | Aventis Pharma Deutschland Gmbh | Recombinant human erythropoietin with an advantageous glycosylation pattern |
| HUP9701554D0 (en) | 1997-09-18 | 1997-11-28 | Human Oltoanyagtermeloe Gyogys | Pharmaceutical composition containing plazma proteins |
| DE69801970T2 (en) | 1997-09-21 | 2002-06-13 | Schering Corp., Kenilworth | Combination therapy for the removal of detectable HCV-RNA in patients with chronic hepatitis C infection |
| US6172046B1 (en)* | 1997-09-21 | 2001-01-09 | Schering Corporation | Combination therapy for eradicating detectable HCV-RNA in patients having chronic Hepatitis C infection |
| US6472373B1 (en) | 1997-09-21 | 2002-10-29 | Schering Corporation | Combination therapy for eradicating detectable HCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection |
| PT1017413E (en) | 1997-09-23 | 2003-02-28 | Rentschler Biotech Gmbh | LIQUID INTERFERENCE FORMULATIONS (BETA) |
| US6117949A (en) | 1998-10-01 | 2000-09-12 | Macromed, Inc. | Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| US6004573A (en) | 1997-10-03 | 1999-12-21 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| US6201072B1 (en)* | 1997-10-03 | 2001-03-13 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| EP1042342A4 (en)* | 1997-10-09 | 2003-04-09 | Human Genome Sciences Inc | 53 human secreted proteins |
| WO1999023105A1 (en) | 1997-11-03 | 1999-05-14 | Human Genome Sciences, Inc. | Vegi, an inhibitor of angiogenesis and tumor growth |
| EP1037921B1 (en) | 1997-12-03 | 2014-09-24 | Roche Diagnostics GmbH | Erythropoietin with high specific activity |
| EP1049486A4 (en) | 1997-12-05 | 2006-01-04 | Lilly Co Eli | Glp-1 formulations |
| JP4278863B2 (en)* | 1997-12-08 | 2009-06-17 | ブリストル−マイヤーズ スクイブ カンパニー | Novel salt and method of metformin |
| CA2312188C (en) | 1997-12-08 | 2010-06-29 | Lexigen Pharmaceuticals Corp. | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
| US6380357B2 (en) | 1997-12-16 | 2002-04-30 | Eli Lilly And Company | Glucagon-like peptide-1 crystals |
| KR100253916B1 (en) | 1997-12-29 | 2000-05-01 | 김충환 | Method for preparing human insulin precursor |
| US5951996A (en) | 1998-02-04 | 1999-09-14 | Czeizler Zaharia; Veronica L. | Treatment of chronic diffuse GI bleeding with erythropoietin |
| US6017545A (en)* | 1998-02-10 | 2000-01-25 | Modi; Pankaj | Mixed micellar delivery system and method of preparation |
| US6221378B1 (en)* | 1998-02-10 | 2001-04-24 | Generex Pharmaceuticals Incorporated | Mixed micellar delivery system and method of preparation |
| AU759058C (en) | 1998-02-13 | 2005-09-15 | Amylin Pharmaceuticals, Inc. | Inotropic and diuretic effects of exendin and GLP-1 |
| DE69942306D1 (en) | 1998-02-27 | 2010-06-10 | Novo Nordisk As | ABSTRACT OF GLP-1 ANALOG |
| WO1999047160A1 (en) | 1998-03-13 | 1999-09-23 | Novo Nordisk A/S | Stabilized aqueous peptide solutions |
| AU3087599A (en) | 1998-03-19 | 1999-10-11 | Bionebraska, Inc. | Human appetite control by glucagon-like peptide receptor binding compounds |
| DE19813802A1 (en) | 1998-03-27 | 1999-11-11 | Retro Tech Gmbh | Anti-viral effects of propolis through inhibition of viral nucleic acid polymerases |
| GB9806631D0 (en) | 1998-03-28 | 1998-05-27 | Safeglass Europ Limited | Safetyglass |
| AU3047299A (en) | 1998-04-13 | 1999-11-01 | Modex Therapeutiques, S.A. | Methods of delivering glp-1 |
| CA2270320A1 (en) | 1998-04-28 | 1999-10-28 | Patricia Lee Brubaker | Novel microsphere composition |
| US6251868B1 (en) | 1998-04-30 | 2001-06-26 | Teijin Limited | Method for treating a human immunodeficiency virus infection |
| TWI277424B (en)* | 1998-05-15 | 2007-04-01 | Schering Corp | Combination therapy for eradicating detectable NCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection |
| CN1119352C (en) | 1998-05-15 | 2003-08-27 | 中国科学院上海生物化学研究所 | Express and purification of human serum albumin in pichia |
| US5970300A (en)* | 1998-06-01 | 1999-10-19 | Xerox Corporation | Apparatus for applying scents to paper in a printer/copier |
| SE9802080D0 (en) | 1998-06-11 | 1998-06-11 | Hellstroem | Pharmaceutical composition for the treatment of functional dyspepsia and / or irritable bowel syndrome and new use of substances therein |
| DE69918691T2 (en) | 1998-06-12 | 2005-07-21 | Amylin Pharmaceuticals, Inc., San Diego | GLUCAGONIC PEPTIDE 1 (GLP-1) IMPROVES THE BETA CELLS ANSWER TO GLUCOSE IN PATIENTS WITH REDUCED GLUCOSE TOLERANCE |
| AU775422B2 (en)* | 1998-06-15 | 2004-07-29 | Gtc Biotherapeutics, Inc. | Erythropoietin analog-human serum albumin fusion |
| CN1105727C (en) | 1998-06-17 | 2003-04-16 | 上海海济医药生物工程有限公司 | Production method of recombinant human serum albumin |
| US6194391B1 (en) | 1998-06-24 | 2001-02-27 | Emory University | 3′-azido-2′,3′-dideoxyuridine administration to treat HIV and related test protocol |
| HUP0102577A3 (en) | 1998-06-30 | 2002-02-28 | Novo Nordisk As | Seeding crystals for the preparation of peptides or proteins, process for their preparation and their use |
| AU8508398A (en) | 1998-07-15 | 2000-02-07 | Wisconsin Alumni Research Foundation | Treatment of diabetes with synthetic beta cells |
| EP1932535A3 (en) | 1998-07-31 | 2008-10-29 | Novo Nordisk A/S | Stimulation of beta cell profileration |
| GB9817084D0 (en) | 1998-08-06 | 1998-10-07 | Wood Christopher B | A method for promoting extra-heptic production of proteins for the correction of hypoalbuminaemia,anaemia,thrombocytopenia and/or coagulation disorders |
| WO2000009666A2 (en) | 1998-08-10 | 2000-02-24 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Differentiation of non-insulin producing cells into insulin producing cells by glp-1 or exendin-4 and uses thereof |
| US6346543B1 (en)* | 1998-08-17 | 2002-02-12 | Aventis Pharma S.A. | Use of a taxoid to treat abnormal cell proliferation in the brain |
| CN1314818A (en) | 1998-08-28 | 2001-09-26 | 伊莱利利公司 | Method for administering insulinotropic peptides |
| MY155270A (en) | 1998-09-24 | 2015-09-30 | Lilly Co Eli | Use of glp-1 or analogs in treatment of stroke |
| US6290987B1 (en) | 1998-09-27 | 2001-09-18 | Generex Pharmaceuticals, Inc. | Mixed liposome pharmaceutical formulation with amphiphiles and phospholipids |
| US6193997B1 (en)* | 1998-09-27 | 2001-02-27 | Generex Pharmaceuticals Inc. | Proteinic drug delivery system using membrane mimetics |
| US6284725B1 (en) | 1998-10-08 | 2001-09-04 | Bionebraska, Inc. | Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue |
| US6429197B1 (en) | 1998-10-08 | 2002-08-06 | Bionebraska, Inc. | Metabolic intervention with GLP-1 or its biologically active analogues to improve the function of the ischemic and reperfused brain |
| WO2000023459A1 (en) | 1998-10-16 | 2000-04-27 | Immunex Corporation | Inhibitors of platelet activation and recruitment |
| DK1123313T3 (en) | 1998-10-23 | 2007-06-18 | Amgen Inc | Methods and compositions for the prevention and treatment of anemia |
| AU774156B2 (en) | 1998-10-30 | 2004-06-17 | Novozymes A/S | Glycosylated proteins having reduced allergenicity |
| CA2352538A1 (en) | 1998-11-30 | 2000-06-08 | Eli Lilly And Company | Erythropoietic compounds |
| US6048891A (en)* | 1998-12-17 | 2000-04-11 | Loma Linda University Medical Center | Use of γ-tocopherol and its oxidative metabolite LLU-α in the treatment of natriuretic disease |
| US6312665B1 (en) | 1998-12-21 | 2001-11-06 | Generex Pharmaceuticals Incorporated | Aerosol formulations for buccal and pulmonary application |
| US6294153B1 (en) | 1998-12-21 | 2001-09-25 | Generex Pharmaceuticals, Inc. | Aerosol pharmaceutical formulation for pulmonary and nasal delivery |
| US6271200B1 (en) | 1998-12-21 | 2001-08-07 | Generex Pharmaceuticals Inc. | Proteinic drug delivery system using aerosolized membrane-mimetic amphiphiles |
| JP4689833B2 (en) | 1998-12-22 | 2011-05-25 | イーライ リリー アンド カンパニー | Storage-stable formulation of glucagon-like peptide-1 |
| GB9902000D0 (en) | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
| US7232889B2 (en)* | 1999-03-08 | 2007-06-19 | Genentech, Inc. | PRO300 antibodies |
| AU4451300A (en) | 1999-04-09 | 2000-11-14 | Human Genome Sciences, Inc. | 48 human secreted proteins |
| JP2002542183A (en) | 1999-04-16 | 2002-12-10 | ノボ ノルディスク アクティーゼルスカブ | Moldable dry pharmaceutical formulation |
| US6287588B1 (en) | 1999-04-29 | 2001-09-11 | Macromed, Inc. | Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof |
| DE19921537A1 (en) | 1999-05-11 | 2000-11-23 | Dieter Hoersch | Treating carbohydrate metabolism disorders, especially diabetes, comprises activating insulin-secreting b-cells using glucagon-related peptide, glucose-dependent insulinotropic polypeptide, exendin-4 or related drugs |
| US6348192B1 (en)* | 1999-05-11 | 2002-02-19 | Bayer Corporation | Interleukin-2 mutein expressed from mammalian cells |
| WO2000069911A1 (en) | 1999-05-17 | 2000-11-23 | Conjuchem, Inc. | Long lasting insulinotropic peptides |
| US6514500B1 (en)* | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
| EP1187852B1 (en) | 1999-05-19 | 2007-08-08 | EMD Lexigen Research Center Corp. | EXPRESSION AND EXPORT OF INTERFERON-ALPHA PROTEINS AS Fc FUSION PROTEINS |
| US6344180B1 (en) | 1999-06-15 | 2002-02-05 | Bionebraska, Inc. | GLP-1 as a diagnostic test to determine β-cell function and the presence of the condition of IGT and type II diabetes |
| ES2291210T3 (en) | 1999-06-21 | 2008-03-01 | Eli Lilly And Company | SYNERGISTIC USE OF THIAZOLIDINDIONAS WITH PEPTIDO-1 TYPE GLUCAGONA AND ITS AGONISTS TO TREAT NON-INSULIN-DEPENDENT DIABETES. |
| JO2291B1 (en)* | 1999-07-02 | 2005-09-12 | اف . هوفمان لاروش ايه جي | Erythopintin derivatives |
| US20020048571A1 (en)* | 1999-07-19 | 2002-04-25 | Jeno Gyuris | Chimeric polypeptides of serum albumin and uses related thereto |
| WO2001005826A2 (en) | 1999-07-19 | 2001-01-25 | Gpc Biotech Inc. | Chimeric polypeptides of serum albumin and uses related thereto |
| CA2382148A1 (en) | 1999-08-17 | 2001-02-22 | Human Genome Sciences, Inc. | 25 human secreted proteins |
| US7144574B2 (en)* | 1999-08-27 | 2006-12-05 | Maxygen Aps | Interferon β variants and conjugates |
| TW200528436A (en) | 1999-09-22 | 2005-09-01 | Bristol Myers Squibb Co | Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method |
| PH12000002657B1 (en) | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
| CA2388432A1 (en) | 1999-10-21 | 2001-04-26 | Monsanto Company | Post-translational modification of recombinant proteins produced in plants |
| WO2001030320A1 (en) | 1999-10-22 | 2001-05-03 | Amgen Inc. | Biodegradable microparticles with novel erythropoietin stimulating protein |
| DE60037535D1 (en) | 1999-11-03 | 2008-01-31 | Novo Nordisk As | USE OF A GROWTH HORMONE OR A GROWTH HORMONE SECRETION THROUGH MEANS OF APPETITE SUPPRESSION OR SATURATION INDUCTION |
| CA2324801A1 (en) | 1999-11-10 | 2001-05-10 | Andrew Gordon Swick | Use of apo b secretion/mtp inhibitors and anti-obesity agents |
| JP2003514552A (en) | 1999-11-12 | 2003-04-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | Erythropoietin morphology with improved properties |
| US6569832B1 (en)* | 1999-11-12 | 2003-05-27 | Novo Nordisk A/S | Inhibition of beta cell degeneration |
| CN100475953C (en) | 1999-12-06 | 2009-04-08 | 通用医疗公司 | pancreatic stem cells |
| US20020025306A1 (en) | 2000-01-07 | 2002-02-28 | Baetge Edward E. | Methods of increasing the glucose responsiveness of pancreatic ss-cells |
| EP1125579A3 (en) | 2000-01-18 | 2003-01-02 | Pfizer Products Inc. | Uses of agrp-melanocortin receptor binding modulating compounds |
| TR200401142T4 (en) | 2000-01-27 | 2004-07-21 | Eli Lilly And Company | Process for dissolving glucagon-like peptide compounds. |
| AU2001228327A1 (en) | 2000-01-31 | 2001-08-14 | Novo-Nordisk A/S | Crystallisation of a glp-1 analogue |
| AU2001252201A1 (en) | 2000-03-14 | 2001-09-24 | Amylin Pharmaceuticals, Inc. | Effects of glucagon-like peptide-1 (7-36) on antro-pyloro-duodenal motility |
| US20050100991A1 (en) | 2001-04-12 | 2005-05-12 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| JP2003530838A (en)* | 2000-04-12 | 2003-10-21 | ヒューマン ゲノム サイエンシズ インコーポレイテッド | Albumin fusion protein |
| US6946134B1 (en) | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| DE60134003D1 (en) | 2000-04-21 | 2008-06-26 | Amgen Inc | METHOD AND COMPOSITIONS FOR AVOIDING AND TREATING ANEMIA |
| IL142707A0 (en) | 2000-04-27 | 2002-03-10 | Pfizer Prod Inc | Methods of treating obesity using a neurotensin receptor ligand |
| DE60109625T3 (en)* | 2000-05-15 | 2017-08-03 | F. Hoffmann-La Roche Ag | LIQUID MEDICINE PREPARATION CONTAINING AN ERYTHROPOIETIN DERIVATIVE |
| US20020061838A1 (en) | 2000-05-17 | 2002-05-23 | Barton Holmquist | Peptide pharmaceutical formulations |
| ATE424413T1 (en) | 2000-06-16 | 2009-03-15 | Lilly Co Eli | ANALOGUE OF GLUCAGONE-LIKE PEPTIDE-1 |
| JP5161412B2 (en) | 2000-09-18 | 2013-03-13 | サノス・バイオサイエンス・アクティーゼルスカブ | Methods of using GLP-1 and GLP-2 peptides |
| US7101561B2 (en)* | 2000-12-01 | 2006-09-05 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
| WO2002045712A1 (en) | 2000-12-04 | 2002-06-13 | Biovitrum Ab | Novel method and use |
| CN101712722A (en)* | 2000-12-07 | 2010-05-26 | 伊莱利利公司 | Glp-1 fusion proteins |
| EP1351984A2 (en) | 2000-12-13 | 2003-10-15 | Eli Lilly And Company | Amidated glucagon-like peptide-1 |
| JP2004521093A (en) | 2000-12-13 | 2004-07-15 | イーライ・リリー・アンド・カンパニー | Long-term treatment plan using glucagon-like insulin stimulating peptide |
| US7070973B2 (en) | 2000-12-26 | 2006-07-04 | Board Of Regents Of The University Of Nebraska | Butyrylcholinesterase variants and methods of use |
| WO2002066062A2 (en) | 2001-02-01 | 2002-08-29 | Drucker Daniel J | Enhancement of glp-2 activity |
| KR100399337B1 (en) | 2001-02-07 | 2003-09-26 | 드림바이오젠 주식회사 | Method for Cell-free Protein Post-translational Modification |
| WO2002069994A2 (en) | 2001-03-07 | 2002-09-12 | Novo Nordisk A/S | Combined use of derivatives of glp-1 analogs and ppar ligands |
| US20020169128A1 (en) | 2001-04-09 | 2002-11-14 | Geroge Sigounas | Erythropoietin ameliorates chemotherapy-induced toxicity in vivo |
| US20050244931A1 (en) | 2001-04-12 | 2005-11-03 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20050054051A1 (en)* | 2001-04-12 | 2005-03-10 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20060084794A1 (en) | 2001-04-12 | 2006-04-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| WO2002085406A1 (en) | 2001-04-24 | 2002-10-31 | Restoragen, Inc. | Methods and compositions for treating conditions associated with insulin resistance |
| EP1401477A4 (en) | 2001-05-25 | 2005-02-02 | Human Genome Sciences | Chemokine beta-1 fusion proteins |
| EP1542712A2 (en) | 2001-06-01 | 2005-06-22 | Eli Lilly And Company | Glp-1 formulations with protracted time action |
| AU2002319381A1 (en) | 2001-06-20 | 2003-01-21 | Merck Sante | Use of antidiabetics for making a medicine with cicatrizing effect |
| DE60224284T2 (en) | 2001-06-28 | 2008-12-18 | Novo Nordisk A/S | STABLE FORMULATION OF MODIFIED GLP-1 |
| ATE408414T1 (en) | 2001-07-31 | 2008-10-15 | Us Gov Health & Human Serv | GLP 1 EXENDIN 4 PEPTIDE ANALOGUES AND THEIR USES |
| WO2003014318A2 (en) | 2001-08-08 | 2003-02-20 | Genzyme Corporation | Methods for treating diabetes and other blood sugar disorders |
| US7186797B2 (en) | 2001-08-10 | 2007-03-06 | Epix Pharmaceuticals, Inc. | Polypeptide conjugates with extended circulating half-lives |
| EP1432730A4 (en) | 2001-08-23 | 2006-10-11 | Lilly Co Eli | Glucagon-like peptide-1 analogs |
| WO2003030821A2 (en) | 2001-10-05 | 2003-04-17 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP2292271A3 (en) | 2001-10-10 | 2011-09-14 | BioGeneriX AG | Remodelling and glycoconjugation of an antibody |
| AU2002353374A1 (en) | 2001-12-21 | 2003-07-09 | Nexia Biotechnologies, Inc. | Production of butyrylcholinesterases in transgenic mammals |
| KR101271635B1 (en) | 2001-12-21 | 2013-06-12 | 휴먼 게놈 사이언시즈, 인코포레이티드 | Albumin fusion proteins |
| ES2425738T3 (en) | 2001-12-21 | 2013-10-17 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
| US20080194481A1 (en) | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
| US20080167238A1 (en) | 2001-12-21 | 2008-07-10 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
| WO2003059934A2 (en) | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP1572936A2 (en) | 2002-03-05 | 2005-09-14 | Eli Lilly And Company | Heterologous g-csf fusion proteins |
| DE60336555D1 (en)* | 2002-06-21 | 2011-05-12 | Novo Nordisk Healthcare Ag | PEGYLATED GLYCO FORMS OF FACTOR VII |
| CN1241946C (en)* | 2002-07-01 | 2006-02-15 | 美国福源集团 | Human serum albumins recombined merge protein having hyperplasia stimulation function to multiple cells |
| US6913890B2 (en)* | 2002-12-18 | 2005-07-05 | Palo Alto Research Center Incorporated | Process for preparing albumin protein conjugated oligonucleotide probes |
| EP1594530A4 (en) | 2003-01-22 | 2006-10-11 | Human Genome Sciences Inc | Albumin fusion proteins |
| JP4912869B2 (en)* | 2003-02-27 | 2012-04-11 | バクスター・インターナショナル・インコーポレイテッド | A method for effective inactivation of pathogens in biological fluids by irradiation |
| AU2004251145C1 (en) | 2003-06-12 | 2011-04-14 | Eli Lilly And Company | GLP-1 analog fusion proteins |
| PL1729795T3 (en) | 2004-02-09 | 2016-08-31 | Human Genome Sciences Inc | Albumin fusion proteins |
| US20060051859A1 (en) | 2004-09-09 | 2006-03-09 | Yan Fu | Long acting human interferon analogs |
| US7436410B2 (en)* | 2005-04-01 | 2008-10-14 | Seiko Epson Corporation | System and method for programming a controller |
| WO2007021494A2 (en) | 2005-08-12 | 2007-02-22 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7438904B1 (en) | 2005-10-04 | 2008-10-21 | University Of Kentucky Research Foundation | High-activity mutants of butyrylcholinesterase for cocaine hydrolysis and method of generating the same |
| US8008257B2 (en) | 2005-10-20 | 2011-08-30 | University Of Ottawa Heart Institute | ANF fusion proteins |
| EP1816201A1 (en)* | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
| EP2046367A4 (en) | 2006-06-07 | 2009-11-11 | Human Genome Sciences Inc | Albumin fusion proteins |
| US9486507B2 (en)* | 2011-06-10 | 2016-11-08 | Biogen Ma Inc. | Pro-coagulant compounds and methods of use thereof |