AU498131B2 - Production of cephems by cyclization - Google Patents

Production of cephems by cyclization

Info

Publication number: AU498131B2
Authority: AU; Australia
Prior art keywords: cephems; cyclization; production
Prior art date: 1974-02-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Inventor

R. B. and BICKEL H WOODWARD

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Ciba Geigy AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-02-26

Filing date

1974-02-24

Publication date

1979-02-15

1974-02-24Application filed by Ciba Geigy AGfiledCriticalCiba Geigy AG

1974-02-26Priority claimed from CH269374Aexternal-prioritypatent/CH601310A5/en

1974-06-05Priority claimed from CH776674Aexternal-prioritypatent/CH610584A5/en

1976-08-26Publication of AU7849875ApublicationCriticalpatent/AU7849875A/en

1979-02-15Application grantedgrantedCritical

1979-02-15Publication of AU498131B2publicationCriticalpatent/AU498131B2/en

StatusExpiredlegal-statusCriticalCurrent

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/02—Sulfinic acids; Derivatives thereof
- C07C313/04—Sulfinic acids; Esters thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AU78498/75A1974-02-261974-02-24Production of cephems by cyclizationExpiredAU498131B2 (en)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
CHCH11000/74		1974-01-24
CHCH2693/74		1974-02-26
CH269374ACH601310A5 (en)	1974-02-26	1974-02-26	7-Amino-3-hydroxy-2(or 3)-cephem-4-carboxylic acid derivs prepn
CHCH7766/74		1974-06-05
CH776674ACH610584A5 (en)	1974-02-26	1974-06-05	Process for the preparation of 2-(3-amino-2-oxo-4-sulphonylthio-1- azetidinyl)-3-methylenebutyric acid derivatives
CH1100074		1974-08-12

Publications (2)

Publication Number	Publication Date
AU7849875A AU7849875A (en)	1976-08-26
AU498131B2true AU498131B2 (en)	1979-02-15

Family

ID=27173851

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU78498/75AExpiredAU498131B2 (en)	1974-02-26	1974-02-24	Production of cephems by cyclization

Country Status (21)

Country	Link
JP (1)	JPS625919B2 (en)
AR (1)	AR208538A1 (en)
AT (2)	AT337362B (en)
AU (1)	AU498131B2 (en)
BE (1)	BE825919A (en)
BG (1)	BG26201A3 (en)
CA (2)	CA1059988A (en)
DD (1)	DD117074A5 (en)
DE (1)	DE2506330A1 (en)
DK (2)	DK73475A (en)
ES (2)	ES435110A1 (en)
FI (1)	FI66389C (en)
FR (1)	FR2261761B1 (en)
GB (1)	GB1503581A (en)
HU (1)	HU175212B (en)
IE (1)	IE40695B1 (en)
IL (1)	IL46699A (en)
NL (1)	NL7502292A (en)
NO (1)	NO750625L (en)
NZ (1)	NZ176623A (en)
SE (3)	SE431652B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1044247B (en)*	1974-08-02	1980-03-20	Farmaceutici Italia	INTERMEDIATES FOR THE SYNTHESIS OF LACTAMIC DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION
CA1136132A (en)*	1975-02-17	1982-11-23	Teruji Tsuji	Cyclization to form cephem ring and intermediates therefor
JPS5198265A (en)*	1975-02-17	1976-08-30
AT342197B (en)*	1975-02-20	1978-03-28	Ciba Geigy Ag	NEW PROCESS FOR PRODUCING 3-CEPHEM CONNECTIONS
US4029645A (en)*	1975-11-17	1977-06-14	E. R. Squibb & Sons, Inc.	Mercury intermediates useful in the preparation of 2-alkoxy cephalosporins
US4301279A (en)	1979-02-23	1981-11-17	Ciba-Geigy Corporation	Process for the production of 3-hydroxy compounds
JPH0639474B2 (en)*	1983-03-04	1994-05-25	大塚化学株式会社	Method for producing cephalosporin compound
JPS59228854A (en)*	1983-06-08	1984-12-22	真井　康博	Chemical liquid injection by compressed gas and chemical liquid storing syringe
JPS60115562A (en)*	1983-11-28	1985-06-22	Otsuka Chem Co Ltd	Production of azetidinone derivative
GB2152497B (en)*	1983-11-28	1987-08-05	Otsuka Kagaku Kk	Process for the preparation of azetidinone derivatives
JPS60126263A (en)*	1983-12-12	1985-07-05	Otsuka Chem Co Ltd	Production of azetidinone derivative
JPS60237061A (en)*	1984-05-08	1985-11-25	Otsuka Chem Co Ltd	Preparation of azetidinone derivative
JPS61178961A (en)*	1985-02-01	1986-08-11	Otsuka Chem Co Ltd	Production of azetidinone derivative
DE3725375A1 (en)*	1987-07-31	1989-02-09	Bayer Ag	STABLE OXAPENEM-3-CARBONSAEURES
JP3195959B2 (en)*	1991-03-13	2001-08-06	大塚化学株式会社	Method for producing 3-hydroxycephem derivative
KR20050087791A (en)*	2002-11-01	2005-08-31	오키드 케미칼즈 앤드 파마수티컬즈 리미티드	An improved process for the preparation of chloro methyl cephem derivatives
CA2856179C (en)	2011-12-20	2017-02-28	F. Hoffmann-La Roche Ag	2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication
PT2794628T (en)	2011-12-20	2017-07-05	Riboscience Llc	4'-azido-3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication
US20180200280A1 (en)	2013-05-16	2018-07-19	Riboscience Llc	4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
MX2015015781A (en)	2013-05-16	2016-06-02	Riboscience Llc	4'-azido, 3'-deoxy-3'-fluoro substituted nucleoside derivatives.
MX2015015782A (en)	2013-05-16	2016-06-02	Riboscience Llc	4'-fluor0-2'-methyl substituted nucleoside derivatives.
US10682369B2 (en)	2017-09-21	2020-06-16	Riboscience Llc	4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2230372A1 (en)*	1972-06-21	1973-01-11	Fujisawa Pharmaceutical Co	Cepham and cephem derivs - useful as antibiotics
AR206201A1 (en)*	1972-06-29	1976-07-07	Ciba Geigy Ag	PROCEDURE FOR OBTAINING ACID COMPOUNDS 7BETA-AMINO-3-CEFEM-3-01-4-CARBOXILICO0-SUBSTITUIDOS
SE428022B (en)*	1972-06-29	1983-05-30	Ciba Geigy Ag	7BETA-AMINO-CEFAM-3-ON-4-CARBOXYLIC ACID COMPOUNDS FOR USE FOR THE PRODUCTION OF CEPHALOSPORINE DERIVATIVES

1974
- 1974-02-24AUAU78498/75Apatent/AU498131B2/ennot_activeExpired
1975
- 1975-02-06SESE7501317Apatent/SE431652B/ennot_activeIP Right Cessation
- 1975-02-12NZNZ176623Apatent/NZ176623A/enunknown
- 1975-02-13ATAT108275Apatent/AT337362B/ennot_activeIP Right Cessation
- 1975-02-14DEDE19752506330patent/DE2506330A1/ennot_activeCeased
- 1975-02-21FIFI750503Apatent/FI66389C/ennot_activeIP Right Cessation
- 1975-02-24DDDD184382Apatent/DD117074A5/xxunknown
- 1975-02-24FRFR7505654Apatent/FR2261761B1/frnot_activeExpired
- 1975-02-24BGBG029066Apatent/BG26201A3/enunknown
- 1975-02-24GBGB7625/75Apatent/GB1503581A/ennot_activeExpired
- 1975-02-24NONO750625Apatent/NO750625L/nounknown
- 1975-02-25ILIL46699Apatent/IL46699A/enunknown
- 1975-02-25CACA220,745Apatent/CA1059988A/ennot_activeExpired
- 1975-02-25DKDK73475*#Apatent/DK73475A/danot_activeApplication Discontinuation
- 1975-02-25HUHU75CI1550Apatent/HU175212B/enunknown
- 1975-02-25BEBE153680Apatent/BE825919A/ennot_activeIP Right Cessation
- 1975-02-25IEIE401/75Apatent/IE40695B1/enunknown
- 1975-02-26NLNL7502292Apatent/NL7502292A/ennot_activeApplication Discontinuation
- 1975-02-26ARAR257777Apatent/AR208538A1/enactive
- 1975-02-26ESES435110Apatent/ES435110A1/ennot_activeExpired
- 1975-02-26JPJP50023775Apatent/JPS625919B2/janot_activeExpired
1976
- 1976-11-02ESES452915Apatent/ES452915A1/ennot_activeExpired
1978
- 1978-01-16ATAT28178Apatent/AT350068B/ennot_activeIP Right Cessation
- 1978-07-13SESE7807811Apatent/SE438855B/ennot_activeIP Right Cessation
- 1978-07-13SESE7807810Apatent/SE438854B/ennot_activeIP Right Cessation
- 1978-08-07DKDK348678Apatent/DK348678A/ennot_activeApplication Discontinuation
1979
- 1979-04-06CACA325,019Apatent/CA1080713A/ennot_activeExpired

Also Published As

Publication number	Publication date
IE40695B1 (en)	1979-08-01
HU175212B (en)	1980-06-28
BG26201A3 (en)	1979-02-15
AR208538A1 (en)	1977-02-15
IL46699A (en)	1977-11-30
FI750503A7 (en)	1975-08-27
BE825919A (en)	1975-08-25
FR2261761A1 (en)	1975-09-19
NZ176623A (en)	1978-04-03
ATA28178A (en)	1978-10-15
IL46699A0 (en)	1975-04-25
FI66389C (en)	1984-10-10
NL7502292A (en)	1975-08-28
AU7849875A (en)	1976-08-26
DD117074A5 (en)	1975-12-20
JPS625919B2 (en)	1987-02-07
CA1059988A (en)	1979-08-07
ATA108275A (en)	1976-10-15
SE431652B (en)	1984-02-20
ES435110A1 (en)	1977-03-16
DE2506330A1 (en)	1975-09-04
SE7501317L (en)	1975-08-27
IE40695L (en)	1975-08-26
FI66389B (en)	1984-06-29
SE438855B (en)	1985-05-13
GB1503581A (en)	1978-03-15
DK73475A (en)	1975-10-20
AT350068B (en)	1979-05-10
SE438854B (en)	1985-05-13
CA1080713A (en)	1980-07-01
AT337362B (en)	1977-06-27
ES452915A1 (en)	1977-11-01
FR2261761B1 (en)	1978-08-18
SE7807811L (en)	1978-07-13
NO750625L (en)	1975-08-27
SE7807810L (en)	1978-07-13
DK348678A (en)	1978-08-07
JPS50129590A (en)	1975-10-13

Publication	Publication Date	Title
AU498131B2 (en)	1979-02-15	Production of cephems by cyclization
JPS533588A (en)	1978-01-13	Production of antibiotic
AU504320B2 (en)	1979-10-11	Production of polyolefins
AU497074B2 (en)	1978-11-23	Production of polyhydric alcohols
CA1030556A (en)	1978-05-02	Process for the production of hydroxy-pivaldehyde
AU490659B2 (en)	1975-10-23	Improvements inthe production of laminates
JPS5214793A (en)	1977-02-03	Production of cephalosporin compound
JPS5251389A (en)	1977-04-25	Production of cephalosporin intermediate
AU507241B2 (en)	1980-02-07	Production of tetrahydrofuran
CA1016091A (en)	1977-08-23	Production of deacetoxycephalosporin c
JPS51142597A (en)	1976-12-08	Production of novel antibiotic
JPS5265295A (en)	1977-05-30	Production of antibiotic
AU499371B2 (en)	1979-04-12	Production of triazole derivatives
JPS5775985A (en)	1982-05-12	Manufacture of substituted penicillins
JPS51125078A (en)	1976-11-01	Production of substituted 11sulphonylbenzimidazole
AU497735B2 (en)	1979-01-04	Production of chlorinated hydrocarbons
JPS5253890A (en)	1977-04-30	Production of cephalosporin type compound
CA1032160A (en)	1978-05-30	Preparation of penicillins
AU495506B2 (en)	1975-12-11	Production of batting
JPS51122089A (en)	1976-10-25	Production of cephalosporin
JPS51125708A (en)	1976-11-02	Production of betaalactam antibiotic complex
AU479133B2 (en)	1976-10-23	Production of refractory objects
AU491584B2 (en)	1976-07-22	Production of fibrils
CA1005640A (en)	1977-02-22	Production of reducing gases
AU508238B2 (en)	1980-03-13	Production of 2-amino-2-alkylthio-nitroethylenes

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