AU2288992A - Further novel 5-amino-4-hydroxyhexanoic acid derivatives as therapeutic agents - Google Patents

Further novel 5-amino-4-hydroxyhexanoic acid derivatives as therapeutic agents

Info

Publication number: AU2288992A
Authority: AU; Australia
Prior art keywords: amino; therapeutic agents; acid derivatives; hydroxyhexanoic acid; further novel
Prior art date: 1991-09-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Inventor

Guido Dr. Bold

Alexander Dr. Fassler

Marc Dr. Lang

Peter Dr. Schneider

Peter Dr. Van Hoogevest

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Novartis AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-12

Filing date

1992-09-10

Publication date

1993-03-18

1992-09-10Application filed by Novartis AGfiledCriticalNovartis AG

1993-03-18Publication of AU2288992ApublicationCriticalpatent/AU2288992A/en

1995-07-13Application grantedgrantedCritical

1995-07-13Publication of AU661018B2publicationCriticalpatent/AU661018B2/en

1997-11-20Assigned to NOVARTIS AGreassignmentNOVARTIS AGRequest to Amend Deed and RegisterAssignors: CIBA-GEIGY AG

2012-09-10Anticipated expirationlegal-statusCritical

StatusCeasedlegal-statusCriticalCurrent

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Virology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Tropical Medicine & Parasitology (AREA)
Crystallography & Structural Chemistry (AREA)
AIDS & HIV (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AU22889/92A1991-09-121992-09-10Further novel 5-amino-4-hydroxyhexanoic acid derivatives as therapeutic agentsCeasedAU661018B2 (en)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
CH2689/91		1991-09-12
CH268991		1991-09-12
CH980/92		1992-03-27
CH98092		1992-03-27
CH2007/92		1992-06-25
CH200792		1992-06-25

Publications (2)

Publication Number	Publication Date
AU2288992Atrue AU2288992A (en)	1993-03-18
AU661018B2 AU661018B2 (en)	1995-07-13

Family

ID=27172572

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU22889/92ACeasedAU661018B2 (en)	1991-09-12	1992-09-10	Further novel 5-amino-4-hydroxyhexanoic acid derivatives as therapeutic agents

Country Status (15)

Country	Link
EP (1)	EP0532466A3 (en)
JP (1)	JPH05230095A (en)
KR (1)	KR930006050A (en)
AU (1)	AU661018B2 (en)
CA (1)	CA2077948A1 (en)
CZ (1)	CZ280292A3 (en)
FI (1)	FI924035A7 (en)
HU (1)	HUT63632A (en)
IL (1)	IL103126A (en)
MX (1)	MX9205208A (en)
NO (1)	NO923533L (en)
NZ (1)	NZ244288A (en)
PL (1)	PL169969B1 (en)
RU (1)	RU2067585C1 (en)
SK (1)	SK280292A3 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995007269A1 (en)*	1993-09-10	1995-03-16	Narhex Limited	Polar-substituted hydrocarbons
US5679688A (en)*	1992-03-11	1997-10-21	Narhex Limited	Quinaldoyl-amine derivatives of oxo-and hydroxy-substituted hydrocarbons
AU695516B2 (en)*	1993-09-13	1998-08-13	Abbott Laboratories	Pharmaceutical composition of HIV-protease inhibitors
US5888992A (en)*	1992-03-11	1999-03-30	Narhex Limited	Polar substituted hydrocarbons
US6071895A (en)	1992-03-11	2000-06-06	Narhex Limited	Polar-substituted hydrocarbons
US6258806B1 (en)	1992-03-11	2001-07-10	Narhex Limited	Amine derivatives of oxo- and hydroxy- substituted hydrocarbons

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5643878A (en)*	1991-09-12	1997-07-01	Ciba-Geigy Corporation	5-amino-4-hydroxyhexanoic acid derivatives
TW217410B (en)*	1992-04-01	1993-12-11	Ciba Geigy
ES2093394T3 (en)	1992-12-23	1996-12-16	Ciba Geigy Ag	ANTIRETROVIRAL HYDRAZINE DERIVATIVES.
EP0618222A3 (en)*	1993-03-11	1997-01-02	Ciba Geigy Ag	Dipeptid derivatives of 5-amino-4-hydroxy-hexanoic acid.
EP0626178A1 (en)*	1993-05-17	1994-11-30	Ciba-Geigy Ag	Use of inhibitors of HIV-protease for the treatment of tumorous diseases
US5559158A (en)*	1993-10-01	1996-09-24	Abbott Laboratories	Pharmaceutical composition
IL111991A (en)*	1994-01-28	2000-07-26	Abbott Lab	Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent
WO1996016980A1 (en)*	1994-11-29	1996-06-06	Novartis Ag	Morpholinoethylamide derivatives
US6037157A (en)	1995-06-29	2000-03-14	Abbott Laboratories	Method for improving pharmacokinetics
US5817757A (en)*	1995-10-30	1998-10-06	Merck & Co., Inc.	Inhibitors of peptide binding to MHO class II proteins
WO1997016188A1 (en)*	1995-10-30	1997-05-09	Merck & Co., Inc.	Novel inhibitors of peptide binding to mhc class ii proteins
US5840835A (en)*	1995-10-30	1998-11-24	Merck & Co., Inc.	Inhibitors of peptide binding to MHC class II proteins
US5914332A (en)	1995-12-13	1999-06-22	Abbott Laboratories	Retroviral protease inhibiting compounds
US6232333B1 (en)	1996-11-21	2001-05-15	Abbott Laboratories	Pharmaceutical composition
CN1343219A (en)*	1999-01-28	2002-04-03	中外制药株式会社	Substituted phenethylamine derivatives
US6455734B1 (en)*	2000-08-09	2002-09-24	Magnesium Diagnostics, Inc.	Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
KR100708221B1 (en)	1999-08-31	2007-04-17	아지노모토 가부시키가이샤	Method for producing epoxide crystal
PT1248600E (en)	2000-01-19	2008-08-25	Abbott Lab	Improved hiv protease inhibitors pharmaceutical formulations
US6506786B2 (en)*	2001-02-13	2003-01-14	Pharmacor Inc.	HIV protease inhibitors based on amino acid derivatives
UA79834C2 (en)*	2002-11-01	2007-07-25	Viropharma Inc	Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
US7388008B2 (en)	2004-08-02	2008-06-17	Ambrilia Biopharma Inc.	Lysine based compounds
CN101405293B (en)	2005-11-30	2013-03-13	中裕新药股份有限公司	Lysine-based prodrugs of aspartyl protease inhibitors and methods of making the same
JP5161793B2 (en)	2006-01-27	2013-03-13	フィブロジェン，インコーポレイテッド	Cyanoisoquinoline compounds that stabilize hypoxia-inducing factor (HIF)
BRPI0710527B8 (en)	2006-04-04	2021-05-25	Fibrogen Inc	pyrrolo- and thiazolo-pyridine compounds and pharmaceutical composition comprising them
AU2007337830A1 (en)	2006-09-21	2008-07-03	Ambrilia Biopharma Inc.	Benzenesulfonamide derivatives as HIV protease inhibitors
JP5649584B2 (en)	2008-11-14	2015-01-07	フィブロジェンインコーポレイテッド	Thiochromene derivatives as HIF hydroxylase inhibitors
SG11201505748UA (en)	2013-01-24	2015-08-28	Fibrogen Inc	Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid
CN115466316A (en)*	2021-06-10	2022-12-13	首都医科大学	Migration-inhibiting 1-imidazole-beta-carboline-3-formyl-RGDF, preparation, anti-cancer metastasis effect and application

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5126326A (en)*	1989-06-06	1992-06-30	Bio-Mega, Inc.	Enzyme inhibiting peptide derivatives

1992
- 1992-09-03EPEP19920810678patent/EP0532466A3/ennot_activeCeased
- 1992-09-07JPJP4238424Apatent/JPH05230095A/enactivePending
- 1992-09-09FIFI924035Apatent/FI924035A7/ennot_activeApplication Discontinuation
- 1992-09-09KRKR1019920016530Apatent/KR930006050A/ennot_activeWithdrawn
- 1992-09-10NZNZ244288Apatent/NZ244288A/enunknown
- 1992-09-10CACA002077948Apatent/CA2077948A1/ennot_activeAbandoned
- 1992-09-10AUAU22889/92Apatent/AU661018B2/ennot_activeCeased
- 1992-09-10ILIL103126Apatent/IL103126A/ennot_activeIP Right Cessation
- 1992-09-11PLPL92295905Apatent/PL169969B1/enunknown
- 1992-09-11SKSK2802-92Apatent/SK280292A3/enunknown
- 1992-09-11RUSU925052915Apatent/RU2067585C1/enactive
- 1992-09-11NONO92923533Apatent/NO923533L/enunknown
- 1992-09-11MXMX9205208Apatent/MX9205208A/ennot_activeIP Right Cessation
- 1992-09-11CZCS922802Apatent/CZ280292A3/enunknown
- 1992-09-11HUHU9202925Apatent/HUT63632A/enunknown

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5679688A (en)*	1992-03-11	1997-10-21	Narhex Limited	Quinaldoyl-amine derivatives of oxo-and hydroxy-substituted hydrocarbons
US5888992A (en)*	1992-03-11	1999-03-30	Narhex Limited	Polar substituted hydrocarbons
US5942504A (en)*	1992-03-11	1999-08-24	Narhex Limited	Amine derivatives of oxo- and hydroxy- substituted hydrocarbons
US6071895A (en)	1992-03-11	2000-06-06	Narhex Limited	Polar-substituted hydrocarbons
US6258806B1 (en)	1992-03-11	2001-07-10	Narhex Limited	Amine derivatives of oxo- and hydroxy- substituted hydrocarbons
WO1995007269A1 (en)*	1993-09-10	1995-03-16	Narhex Limited	Polar-substituted hydrocarbons
AU695516B2 (en)*	1993-09-13	1998-08-13	Abbott Laboratories	Pharmaceutical composition of HIV-protease inhibitors

Also Published As

Publication number	Publication date
CZ280292A3 (en)	1994-01-19
JPH05230095A (en)	1993-09-07
HUT63632A (en)	1993-09-28
PL295905A1 (en)	1993-05-17
IL103126A (en)	1997-09-30
CA2077948A1 (en)	1993-03-13
NO923533L (en)	1993-03-15
RU2067585C1 (en)	1996-10-10
SK280292A3 (en)	1995-02-08
EP0532466A2 (en)	1993-03-17
PL169969B1 (en)	1996-09-30
AU661018B2 (en)	1995-07-13
EP0532466A3 (en)	1993-06-16
KR930006050A (en)	1993-04-20
HU9202925D0 (en)	1992-11-30
MX9205208A (en)	1993-03-01
NZ244288A (en)	1995-03-28
IL103126A0 (en)	1993-02-21
NO923533D0 (en)	1992-09-11
FI924035A0 (en)	1992-09-09
FI924035A7 (en)	1993-03-13

Publication	Publication Date	Title
AU661018B2 (en)	1995-07-13	Further novel 5-amino-4-hydroxyhexanoic acid derivatives as therapeutic agents
AU1803092A (en)	1993-01-07	7-azaisoindolinyl-quinolone- and-naphthyridonecarboxylic acid derivatives
AU7122291A (en)	1991-08-29	3-arylcarbonyl-1h-indoles useful as therapeutic agents
AU1739192A (en)	1992-12-24	7-isoindolinyl-quinolone- and -naphthyridonecarboxylic acid derivatives
AU3105493A (en)	1993-07-15	Quinolone- and naphthyridone-carboxylic acid derivatives
AU1025792A (en)	1992-08-06	Amino acid derivatives
AU4566589A (en)	1990-06-07	Beta-amino-boronic acid derivatives
AU3020595A (en)	1996-03-14	Use of substituted 4-phenyl-6-amino-nicotinic acid derivatives as medicaments
IL103538A0 (en)	1993-03-15	Quinoxaline-carboxylic and-phosphonic acid derivatives
AU5184193A (en)	1994-06-09	Diaminobenzoic acid derivatives
AU7184994A (en)	1995-01-17	Imidazole derivatives as therapeutic agents
AU1308988A (en)	1988-09-15	Therapeutic compositions
AU646596B2 (en)	1994-02-24	Substituted imidazolyl-propenoic acid derivatives
AU3108293A (en)	1993-07-15	Benzofuranyl- and thiophenylmethylthio-alkanecarboxylic acid derivatives
AU646762B2 (en)	1994-03-03	Cyclic-substituted imidazolyl-propenoic acid derivatives
AU6892291A (en)	1991-06-13	4-hydroxyquinaldic acid derivatives
AU646977B2 (en)	1994-03-10	Imidazolyl-propenoic acid derivatives
AU2979892A (en)	1993-06-10	Thiazolyl-substituted quinolylmethoxphenylacetic acid derivatives
HU9302728D0 (en)	1993-12-28	Pyridazinone-acetic acid derivatives
AU3376993A (en)	1993-09-02	Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives
ZA926938B (en)	1994-03-11	Further novel 5-amino-4-hydroxyhexanoic acid derivatives as therapeutic agents
AU1761192A (en)	1992-11-17	3-amino-5-arylpyrazole-4-acetic acid derivatives exhibiting therapeutic effects
AU2841392A (en)	1993-05-20	Amino acid derivatives
AU1509492A (en)	1992-10-29	Novel thienyl-nonatetraenoic acid derivatives
AU5517890A (en)	1990-12-13	Mevinic acid derivatives

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