| US4071409A (en)* | 1976-05-20 | 1978-01-31 | Corning Glass Works | Immobilization of proteins on inorganic support materials |
| US4722896A (en)* | 1981-01-26 | 1988-02-02 | The Beth Israel Hospital Association | Method for affinity purification of hybridoma antibodies |
| US4444879A (en)* | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
| US4514508A (en)* | 1982-07-06 | 1985-04-30 | Biond Inc. | Assaying for a multiplicity of antigens or antibodies with a detection compound |
| US4591570A (en)* | 1983-02-02 | 1986-05-27 | Centocor, Inc. | Matrix of antibody-coated spots for determination of antigens |
| US4816567A (en)* | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4615985A (en)* | 1984-04-16 | 1986-10-07 | Genetic Diagnostics Corporation | Immobilized protein on nylon for immunoassay |
| US4582622A (en)* | 1984-10-12 | 1986-04-15 | Fujirebio Kabushiki Kaisha | Magnetic particulate for immobilization of biological protein and process of producing the same |
| US6060237A (en)* | 1985-02-26 | 2000-05-09 | Biostar, Inc. | Devices and methods for optical detection of nucleic acid hybridization |
| IT8520964U1 (en)* | 1985-03-01 | 1986-09-01 | Alfa Romeo Auto Spa | CONTAINER FOR THE WINDSCREEN WASHER FLUID OF A MOTOR VEHICLE |
| US5200333A (en)* | 1985-03-01 | 1993-04-06 | New England Biolabs, Inc. | Cloning restriction and modification genes |
| US5096807A (en)* | 1985-03-06 | 1992-03-17 | Murex Corporation | Imaging immunoassay detection system with background compensation and its use |
| US5523215A (en)* | 1985-03-28 | 1996-06-04 | Chiron Corporation | Enhanced purification and expression of insoluble recombinant proteins |
| US5866363A (en)* | 1985-08-28 | 1999-02-02 | Pieczenik; George | Method and means for sorting and identifying biological information |
| US4894146A (en)* | 1986-01-27 | 1990-01-16 | University Of Utah | Thin channel split flow process and apparatus for particle fractionation |
| US4802951A (en)* | 1986-03-07 | 1989-02-07 | Trustees Of Boston University | Method for parallel fabrication of nanometer scale multi-device structures |
| US5079600A (en)* | 1987-03-06 | 1992-01-07 | Schnur Joel M | High resolution patterning on solid substrates |
| US4987032A (en)* | 1987-06-26 | 1991-01-22 | Fuji Photo Film Co., Ltd. | Functional organic thin film and method of manufacture thereof |
| CA1340807C (en)* | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| US6692751B1 (en)* | 1988-05-06 | 2004-02-17 | New York Blood Center | Methods and systems for producing recombinant viral antigens |
| US4908112A (en)* | 1988-06-16 | 1990-03-13 | E. I. Du Pont De Nemours & Co. | Silicon semiconductor wafer for analyzing micronic biological samples |
| US5281540A (en)* | 1988-08-02 | 1994-01-25 | Abbott Laboratories | Test array for performing assays |
| US5720928A (en)* | 1988-09-15 | 1998-02-24 | New York University | Image processing and analysis of individual nucleic acid molecules |
| GB8822228D0 (en)* | 1988-09-21 | 1988-10-26 | Southern E M | Support-bound oligonucleotides |
| US5143854A (en)* | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5744101A (en)* | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US6346413B1 (en)* | 1989-06-07 | 2002-02-12 | Affymetrix, Inc. | Polymer arrays |
| US5800992A (en)* | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5252743A (en)* | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
| US5283173A (en)* | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| US5858188A (en)* | 1990-02-28 | 1999-01-12 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
| US5192675A (en)* | 1990-03-20 | 1993-03-09 | Life Technologies, Inc. | Cloned KpnI restriction-modification system |
| US5082784A (en)* | 1990-03-20 | 1992-01-21 | Life Technologies, Inc. | Cloned kpni restriction-modification system |
| US5098839A (en)* | 1990-05-10 | 1992-03-24 | New England Biolabs, Inc. | Type ii restriction endonuclease obtainable from pseudomonas alcaligenes and a process for producing the same |
| US5861254A (en)* | 1997-01-31 | 1999-01-19 | Nexstar Pharmaceuticals, Inc. | Flow cell SELEX |
| US5179015A (en)* | 1990-07-23 | 1993-01-12 | New England Biolabs, Inc. | Heterospecific modification as a means to clone restriction genes |
| JPH04132428A (en)* | 1990-09-25 | 1992-05-06 | Canon Inc | Optical communication system and receiving device used therein |
| US5202248A (en)* | 1990-11-02 | 1993-04-13 | New England Biolabs, Inc. | Method for cloning and producing the nco i restriction endonuclease and methylase |
| US5294369A (en)* | 1990-12-05 | 1994-03-15 | Akzo N.V. | Ligand gold bonding |
| AU1248292A (en)* | 1990-12-06 | 1992-07-08 | Affymax Technologies N.V. | Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides |
| US5763170A (en)* | 1991-04-16 | 1998-06-09 | Amersham International Plc | Method for forming an array of biological particles |
| JP3097866B2 (en)* | 1991-10-15 | 2000-10-10 | マルティライト リミティド | Binding assays using labeling reagents |
| US6051380A (en)* | 1993-11-01 | 2000-04-18 | Nanogen, Inc. | Methods and procedures for molecular biological analysis and diagnostics |
| US5605662A (en)* | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
| US5384261A (en)* | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| US5412087A (en)* | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
| ATE241426T1 (en)* | 1991-11-22 | 2003-06-15 | Affymetrix Inc A Delaware Corp | METHOD FOR PRODUCING POLYMER ARRAYS |
| ES2227512T3 (en)* | 1991-12-02 | 2005-04-01 | Medical Research Council | PRODUCTION OF ANTIBODIES AGAINST SELF-ANTIGENS FROM REPERTORIES OF ANTIBODY SEGMENTS FIXED IN A PHOTO. |
| DE59108591D1 (en)* | 1991-12-06 | 1997-04-10 | Ciba Geigy Ag | Electrophoretic separation device and electrophoretic separation process |
| US6033884A (en)* | 1992-03-20 | 2000-03-07 | Baylor College Of Medicine | Nucleic acid transporter systems and methods of use |
| CA2064683A1 (en)* | 1992-03-26 | 1993-09-27 | Krishna Mohan Rao Kallury | Formation of thermostable enzymes with extra-ordinary heat tolerance by immobilization on phospholipid matrices |
| US6143854A (en)* | 1993-08-06 | 2000-11-07 | Exxon Chemical Patents, Inc. | Polymerization catalysts, their production and use |
| US5231021A (en)* | 1992-04-10 | 1993-07-27 | Life Technologies, Inc. | Cloning and expressing restriction endonucleases and modification methylases from xanthomonas |
| US5304487A (en)* | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
| US5637469A (en)* | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
| US5726026A (en)* | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
| DE4237113B4 (en)* | 1992-11-03 | 2006-10-12 | "Iba Gmbh" | Peptides and their fusion proteins, expression vector and method of producing a fusion protein |
| US5312746A (en)* | 1993-01-08 | 1994-05-17 | Life Technologies, Inc. | Cloning and expressing restriction endonucleases and modification methylases from caryophanon |
| US5512492A (en)* | 1993-05-18 | 1996-04-30 | University Of Utah Research Foundation | Waveguide immunosensor with coating chemistry providing enhanced sensitivity |
| CA2163426C (en)* | 1993-05-28 | 2005-11-01 | T. William Hutchens | Method and apparatus for desorption and ionization of analytes |
| US5861242A (en)* | 1993-06-25 | 1999-01-19 | Affymetrix, Inc. | Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same |
| US5837832A (en)* | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| RU2041262C1 (en)* | 1993-08-11 | 1995-08-09 | Институт молекулярной биологии им.В.А.Энгельгардта РАН | Method for immobilization of water soluble bioorganic compounds on capillary-porous carrier |
| US5512131A (en)* | 1993-10-04 | 1996-04-30 | President And Fellows Of Harvard College | Formation of microstamped patterns on surfaces and derivative articles |
| US6120992A (en)* | 1993-11-04 | 2000-09-19 | Valigene Corporation | Use of immobilized mismatch binding protein for detection of mutations and polymorphisms, and allele identification in a diseased human |
| US5594111A (en)* | 1994-01-28 | 1997-01-14 | Prolinx, Inc. | Phenylboronic acid complexes for bioconjugate preparation |
| US5623055A (en)* | 1994-01-28 | 1997-04-22 | Prolinx, Inc. | Phenylboronic acid complexes derived from aminosalicylic acid for bioconjugate preparation |
| AU1911795A (en)* | 1994-02-09 | 1995-08-29 | Abbott Laboratories | Diagnostic flow cell device |
| US5514501A (en)* | 1994-06-07 | 1996-05-07 | The United States Of America As Represented By The Secretary Of Commerce | Process for UV-photopatterning of thiolate monolayers self-assembled on gold, silver and other substrates |
| US5498545A (en)* | 1994-07-21 | 1996-03-12 | Vestal; Marvin L. | Mass spectrometer system and method for matrix-assisted laser desorption measurements |
| US5620850A (en)* | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
| US5897475A (en)* | 1994-10-05 | 1999-04-27 | Antex Biologics, Inc. | Vaccines comprising enhanced antigenic helicobacter spp. |
| US5585069A (en)* | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
| US5603351A (en)* | 1995-06-07 | 1997-02-18 | David Sarnoff Research Center, Inc. | Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device |
| US5573719A (en)* | 1994-11-30 | 1996-11-12 | Kimberly-Clark Corporation | Process of making highly absorbent nonwoven fabric |
| US5622826A (en)* | 1994-12-22 | 1997-04-22 | Houston Advanced Research Center | Method for immobilization of molecules on platinum solid support surfaces |
| US5599695A (en)* | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
| US5629213A (en)* | 1995-03-03 | 1997-05-13 | Kornguth; Steven E. | Analytical biosensor |
| US5624711A (en)* | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
| US5625184A (en)* | 1995-05-19 | 1997-04-29 | Perseptive Biosystems, Inc. | Time-of-flight mass spectrometry analysis of biomolecules |
| US5817789A (en)* | 1995-06-06 | 1998-10-06 | Transkaryotic Therapies, Inc. | Chimeric proteins for use in transport of a selected substance into cells |
| US5545531A (en)* | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
| US6720149B1 (en)* | 1995-06-07 | 2004-04-13 | Affymetrix, Inc. | Methods for concurrently processing multiple biological chip assays |
| DK0937098T3 (en)* | 1995-06-07 | 2002-12-02 | Invitrogen Corp | Recombinational cloning using genetically engineered recombination sites |
| ATE272058T1 (en)* | 1995-10-17 | 2004-08-15 | Combichem Inc | MATRIZE FOR SYNTHESIS OF COMBINATORIAL LIBRARIES IN SOLUTION |
| US5691152A (en)* | 1995-11-09 | 1997-11-25 | E. R. Squibb & Sons, Inc. | Stable avidin composition |
| US5731152A (en)* | 1996-05-13 | 1998-03-24 | Motorola, Inc. | Methods and systems for biological reagent placement |
| US20030017149A1 (en)* | 1996-10-10 | 2003-01-23 | Hoeffler James P. | Single chain monoclonal antibody fusion reagents that regulate transcription in vivo |
| US6331289B1 (en)* | 1996-10-28 | 2001-12-18 | Nycomed Imaging As | Targeted diagnostic/therapeutic agents having more than one different vectors |
| US5905024A (en)* | 1996-12-17 | 1999-05-18 | University Of Chicago | Method for performing site-specific affinity fractionation for use in DNA sequencing |
| JP4062366B2 (en)* | 1997-01-17 | 2008-03-19 | マキシジェン,インコーポレイテッド | Evolution of whole cells and organisms by recursive sequence recombination |
| US6190619B1 (en)* | 1997-06-11 | 2001-02-20 | Argonaut Technologies, Inc. | Systems and methods for parallel synthesis of compounds |
| NZ516848A (en)* | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
| AU8826598A (en)* | 1997-10-10 | 1999-05-03 | President And Fellows Of Harvard College | Surface-bound, double-stranded dna protein arrays |
| US6061476A (en)* | 1997-11-24 | 2000-05-09 | Cognex Corporation | Method and apparatus using image subtraction and dynamic thresholding |
| US6242246B1 (en)* | 1997-12-15 | 2001-06-05 | Somalogic, Inc. | Nucleic acid ligand diagnostic Biochip |
| WO1999053300A1 (en)* | 1998-04-14 | 1999-10-21 | California Institute Of Technology | Method and system for determining analyte activity |
| US6406921B1 (en)* | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| US6682942B1 (en)* | 1998-07-14 | 2004-01-27 | Zyomyx, Inc. | Microdevices for screening biomolecules |
| US6897073B2 (en)* | 1998-07-14 | 2005-05-24 | Zyomyx, Inc. | Non-specific binding resistant protein arrays and methods for making the same |
| US6190908B1 (en)* | 1998-08-12 | 2001-02-20 | The Scripps Research Institute | Modulation of polypeptide display on modified filamentous phage |
| JP2003524193A (en)* | 2000-02-23 | 2003-08-12 | ザイオミックス インコーポレイテッド | Chip with sample surface positioned high |
| US6531283B1 (en)* | 2000-06-20 | 2003-03-11 | Molecular Staging, Inc. | Protein expression profiling |
| US6699665B1 (en)* | 2000-11-08 | 2004-03-02 | Surface Logix, Inc. | Multiple array system for integrating bioarrays |
| JP2004530421A (en)* | 2001-02-07 | 2004-10-07 | インヴィトロジェン コーポレーション | TER site and TER binding protein |
| US20050026215A1 (en)* | 2003-07-17 | 2005-02-03 | Predki Paul F. | Method for the prediction of an epitope |
| US8148302B2 (en)* | 2005-10-19 | 2012-04-03 | The United States Of America As Represented By The Department Of Health And Human Services | In situ assembling of protein microarrays |