AU2003248122A8 - Sodium channel inhibitor - Google Patents

Sodium channel inhibitor

Info

Publication number: AU2003248122A8
Authority: AU; Australia
Prior art keywords: sodium channel; channel inhibitor; inhibitor; sodium; channel
Prior art date: 2002-07-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Inventor

Toshihiro Watanabe

Yukinori Nagakura

Hiroshi Tomiyama

Motoharu Sonegawa

Kazuo Tokuzaki

Yoshinori Iwai

Kazumi Kikuchi

Makoto Oku

Takeshi Hondo

Tetsuya Kimizuka

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Kotobuki Seiyaku Co Ltd

Yamanouchi Pharmaceutical Co Ltd

Original Assignee

Kotobuki Seiyaku Co Ltd

Yamanouchi Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-25

Filing date

2003-07-25

Publication date

2004-02-16

2003-07-25Application filed by Kotobuki Seiyaku Co Ltd, Yamanouchi Pharmaceutical Co LtdfiledCriticalKotobuki Seiyaku Co Ltd

2004-02-16Publication of AU2003248122A1publicationCriticalpatent/AU2003248122A1/en

2004-02-16Publication of AU2003248122A8publicationCriticalpatent/AU2003248122A8/en

StatusAbandonedlegal-statusCriticalCurrent

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AU2003248122A2002-07-252003-07-25Sodium channel inhibitorAbandonedAU2003248122A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2002216187		2002-07-25
JP2002-216187		2002-07-25
PCT/JP2003/009474WO2004011430A1 (en)	2002-07-25	2003-07-25	Sodium channel inhibitor

Publications (2)

Publication Number	Publication Date
AU2003248122A1 AU2003248122A1 (en)	2004-02-16
AU2003248122A8true AU2003248122A8 (en)	2004-02-16

Family

ID=31184572

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2003248122AAbandonedAU2003248122A1 (en)	2002-07-25	2003-07-25	Sodium channel inhibitor

Country Status (3)

Country	Link
JP (1)	JPWO2004011430A1 (en)
AU (1)	AU2003248122A1 (en)
WO (1)	WO2004011430A1 (en)

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MX2007002541A (en)*	2004-09-01	2007-05-09	Astellas Pharma Inc	Piperidine derivative or pharmaceutically acceptable salt thereof.
WO2006101521A2 (en)	2004-09-20	2006-09-28	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
JP2008513515A (en)	2004-09-20	2008-05-01	ゼノン・ファーマシューティカルズ・インコーポレイテッド	Heterocyclic derivatives and their use as therapeutic agents
US20080167321A1 (en)*	2004-09-20	2008-07-10	Xenon Pharmaceuticals Inc.	Pyridine Derivatives For Inhibiting Human Stearoyl-Coa-Desaturase
GB0503646D0 (en)*	2005-02-22	2005-03-30	Novartis Ag	Organic compounds
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JP5592388B2 (en)*	2008-10-31	2014-09-17	メルク・シャープ・アンド・ドーム・コーポレーション	Technical field of P2X3 receptor antagonist for the treatment of pain
US8809380B2 (en)	2009-08-04	2014-08-19	Raqualia Pharma Inc.	Picolinamide derivatives as TTX-S blockers
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RU2018104472A (en)*	2011-03-18	2019-02-22	Джензим Корпорейшн	Glucosylceramide synthase inhibitors
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ES2983048T3 (en)	2017-09-22	2024-10-21	Jubilant Epipad LLC	Heterocyclic compounds as PAD inhibitors
US11426412B2 (en)	2017-10-18	2022-08-30	Jubilant Epipad LLC	Imidazo-pyridine compounds as PAD inhibitors
AU2018362046B2 (en)	2017-11-06	2023-04-13	Jubilant Prodel LLC	Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
RS65576B1 (en)	2017-11-24	2024-06-28	Jubilant Episcribe Llc	Heterocyclic compounds as prmt5 inhibitors
GB201801355D0 (en)	2018-01-26	2018-03-14	Enterprise Therapeutics Ltd	Compounds
AU2019234185B2 (en)	2018-03-13	2024-08-01	Jubilant Prodel LLC.	Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation
KR20210082473A (en)	2018-10-23	2021-07-05	바스프 에스이	tricyclic insecticidal compounds
AU2021215396A1 (en)	2020-02-03	2022-09-29	Genzyme Corporation	Methods for treating neurological symptoms associated with lysosomal storage diseases
BR112023000798A2 (en)	2020-07-24	2023-02-07	Genzyme Corp	PHARMACEUTICAL COMPOSITIONS COMPRISING VENGLUTAT

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2003
- 2003-07-25JPJP2004524158Apatent/JPWO2004011430A1/ennot_activeWithdrawn
- 2003-07-25WOPCT/JP2003/009474patent/WO2004011430A1/enactiveApplication Filing
- 2003-07-25AUAU2003248122Apatent/AU2003248122A1/ennot_activeAbandoned

Also Published As

Publication number	Publication date
JPWO2004011430A1 (en)	2005-11-24
AU2003248122A1 (en)	2004-02-16
WO2004011430A1 (en)	2004-02-05

Publication	Publication Date	Title
AU2003248122A8 (en)	2004-02-16	Sodium channel inhibitor
EG25482A (en)	2012-01-15	Inhibitors
EP1532133A4 (en)	2006-11-15	Nf-:b inhibitors
EP1501509A4 (en)	2009-07-15	Aryl-link-aryl substituted thiazolidine-dione and oxazolidine-dione as sodium channel blockers
PL397821A1 (en)	2012-03-12	1-acetyl-6-fluoro-2-indolinone compound
AU2003256323A8 (en)	2004-01-19	Sos1 inhibitors
GB0204241D0 (en)	2002-04-10	Compound
EP1531857A4 (en)	2008-10-08	Metalloproteinase inhibitors
GB0225750D0 (en)	2002-12-11	Wiffs away
HRP20050162A2 (en)	2005-06-30	?-lactamase inhibitor prodrug
GB2374269B (en)	2003-04-16	Lawn-edging strip
GB2385877B (en)	2005-08-24	Threshold
GB0224830D0 (en)	2002-12-04	Compound
GB0213027D0 (en)	2002-07-17	Compound
GB0216212D0 (en)	2002-08-21	Sodium channel inhibitors
GB0116730D0 (en)	2001-08-29	Sodium channel inhibitors
IL165935A (en)	2010-12-30	Vasopeptidase inhibitors
GB0217330D0 (en)	2002-09-04	Inhibitors
GB0207488D0 (en)	2002-05-08	Inhibitors
GB0224102D0 (en)	2002-11-27	Inhibitors
GB0226149D0 (en)	2002-12-18	Inhibitors
GB0208094D0 (en)	2002-05-22	Inhibitors
GB0207491D0 (en)	2002-05-08	Inhibitors
GB0206031D0 (en)	2002-04-24	Inhibitors
SI1485359T1 (en)	2008-04-30	Sodium channel blockers

Legal Events

Date	Code	Title	Description
2005-04-14	MK6	Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase
2005-08-18	TH	Corrigenda	Free format text:IN VOL 18, NO 12, PAGE(S) 3443 UNDER THE HEADING APPLICATIONS OPI - NAME INDEX UNDER THE NAME YAMANOUCHI PHARMACEUTICAL CO., LTD., APPLICATION NO. 2003248122, UNDER INID (71) CORRECT THE NAME TO READ KOTOBUKI PHARMACEUTICAL CO., LTD.; YAMANOUCHI PHARMACEUTICAL CO., LTD.

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