| EP0983767B1              (en) | 1997-03-21 | 2008-09-10 | Chugai Seiyaku Kabushiki Kaisha | Preventives or remedies for the treatment of multiple sclerosis containing antagonist anti-IL-6-receptor antibodies | 
| EP3031917A1              (en)* | 1999-04-09 | 2016-06-15 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule | 
| JP4147234B2              (en)* | 2004-09-27 | 2008-09-10 | キヤノン株式会社 | Discharge liquid, discharge method, cartridge, and discharge device | 
| US6946292B2              (en)* | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity | 
| UA80091C2              (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist | 
| SI1478394T1              (en) | 2002-02-27 | 2008-12-31 | Immunex Corp | Stabilized TNFR-Fc composition comprising arginine | 
| EP1946776B1              (en)* | 2002-02-27 | 2017-01-18 | Immunex Corporation | Stabilized tnfr-fc composition comprising arginine | 
| CA2481920A1              (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Antibody composition-containing medicament | 
| US7132100B2              (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations | 
| AU2011226771B2              (en)* | 2002-06-14 | 2012-10-04 | Medimmune, Llc | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations | 
| AU2013201261B2              (en)* | 2002-06-14 | 2016-06-23 | Medimmune, Llc | Stabilized liquid anti-RSV antibody formulations | 
| US7425618B2              (en)* | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations | 
| JP2005530845A              (en)* | 2002-06-21 | 2005-10-13 | アイデック  ファーマシューティカルズ  コーポレイション | Buffered formulations for concentrating antibodies and methods of use thereof | 
| JP2006502116A              (en)* | 2002-07-12 | 2006-01-19 | メダレックス, インク. | Methods and compositions for preventing oxidative degradation of proteins | 
| US20040033228A1              (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders | 
| HUE027134T2              (en) | 2002-09-11 | 2016-10-28 | Chugai Pharmaceutical Co Ltd | Method of purifying protein | 
| WO2004033499A1              (en)* | 2002-10-11 | 2004-04-22 | Chugai Seiyaku Kabushiki Kaisha | Cell death-inducing agent | 
| MY150740A              (en)* | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental | 
| EP1589996A4              (en)* | 2003-01-30 | 2009-01-21 | Medimmune Inc | Anti-integrin alpha beta 3 antibody formulat ions and uses thereof | 
| FR2853551B1              (en)* | 2003-04-09 | 2006-08-04 | Lab Francais Du Fractionnement | STABILIZING FORMULATION FOR IMMUNOGLOBULIN G COMPOSITIONS IN LIQUID FORM AND LYOPHILIZED FORM | 
| GB2401040A              (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases | 
| US8080642B2              (en) | 2003-05-16 | 2011-12-20 | Vical Incorporated | Severe acute respiratory syndrome DNA compositions and methods of use | 
| SI1698640T2              (en) | 2003-10-01 | 2019-08-30 | Kyowa Hakko Kirin Co., Ltd. | Method of stabilizing antibody and stabilized solution-type antibody preparation | 
| EP1710255A4              (en)* | 2003-12-12 | 2008-09-24 | Chugai Pharmaceutical Co Ltd | Modified antibodies recognising receptor trimers or higher multimers | 
| EP3269738A1              (en) | 2004-03-24 | 2018-01-17 | Chugai Seiyaku Kabushiki Kaisha | Subtypes of humanized antibody against interleukin-6 receptor | 
| WO2005100560A1              (en)* | 2004-04-09 | 2005-10-27 | Chugai Seiyaku Kabushiki Kaisha | Cell death inducer | 
| JP4879884B2              (en)* | 2004-04-12 | 2012-02-22 | メディミューン,エルエルシー | Anti-IL-9 antibody preparation and use thereof | 
| TW200621282A              (en) | 2004-08-13 | 2006-07-01 | Wyeth Corp | Stabilizing formulations | 
| US20060051347A1              (en) | 2004-09-09 | 2006-03-09 | Winter Charles M | Process for concentration of antibodies and therapeutic products thereof | 
| JP4147235B2              (en)* | 2004-09-27 | 2008-09-10 | キヤノン株式会社 | Discharge liquid, discharge method, droplet forming method, liquid discharge cartridge, and discharge apparatus | 
| JO3000B1              (en) | 2004-10-20 | 2016-09-05 | Genentech Inc | Antibody Formulations. | 
| EP1871806A2              (en)* | 2005-03-08 | 2008-01-02 | Pharmacia & Upjohn Company LLC | ANTI-MAdCAM ANTIBODY COMPOSITIONS | 
| WO2006106903A1              (en)* | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | sc(Fv)2 STRUCTURAL ISOMERS | 
| JO3058B1              (en) | 2005-04-29 | 2017-03-15 | Applied Molecular Evolution Inc | Anti-IL-6 Antibodies,Compositions,Methods and uses | 
| US9241994B2              (en)* | 2005-06-10 | 2016-01-26 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical compositions containing sc(Fv)2 | 
| CN101237890A              (en)* | 2005-06-10 | 2008-08-06 | 中外制药株式会社 | Stabilizer for protein preparation comprising meglumine and use thereof | 
| TW200718780A              (en)* | 2005-06-10 | 2007-05-16 | Chugai Pharmaceutical Co Ltd | Sc(Fv)2 site-directed mutant | 
| US20080311078A1              (en) | 2005-06-14 | 2008-12-18 | Gokarn Yatin R | Self-Buffering Protein Formulations | 
| MX2007016306A              (en) | 2005-06-15 | 2008-03-07 | Schering Corp | Anti-igf1r antibody formulations. | 
| EP1893647A2              (en)* | 2005-06-23 | 2008-03-05 | MedImmune, Inc. | Antibody formulations having optimized aggregation and fragmentation profiles | 
| JP5033798B2              (en) | 2005-07-02 | 2012-09-26 | アレコー・リミテッド | Stable water system containing protein | 
| GB0610140D0              (en)* | 2006-05-22 | 2006-06-28 | Insense Ltd | Protein stability | 
| CA2615122A1              (en) | 2005-08-03 | 2007-02-15 | Immunogen, Inc. | Immunoconjugate formulations | 
| US8080248B2              (en) | 2006-06-02 | 2011-12-20 | Regeneron Pharmaceuticals, Inc. | Method of treating rheumatoid arthritis with an IL-6R antibody | 
| AU2007254831B2              (en) | 2006-06-02 | 2012-03-22 | Regeneron Pharmaceuticals, Inc. | High affinity antibodies to human IL-6 receptor | 
| CA2657385A1              (en)* | 2006-07-13 | 2008-01-17 | Naoki Kimura | Cell death inducer | 
| SG162834A1              (en)* | 2006-07-14 | 2010-07-29 | Genentech Inc | Refolding of recombinant proteins | 
| AU2007234612B2              (en)* | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations | 
| US20080177614A1              (en)* | 2007-01-24 | 2008-07-24 | Lianjun An | Method and system for estimating dynamics of workforce absenteeism using information on pandemic spread and mitigation actions | 
| US7746769B2              (en)* | 2007-03-26 | 2010-06-29 | Alcatel Lucent | Management of redundant and multi-segment pseudo-wire | 
| CN101679507A              (en) | 2007-03-29 | 2010-03-24 | 艾博特公司 | crystalline anti-human il-12 antibodies | 
| JP5513380B2              (en)* | 2007-06-25 | 2014-06-04 | アムジエン・インコーポレーテツド | Composition of specific binding agents for hepatocyte growth factor | 
| EP2205276A4              (en)* | 2007-09-28 | 2012-08-15 | Janssen Biotech Inc | Anti-il-12/23p40 antibodies, epitopes, formulations, compositions, methods and uses | 
| US8883146B2              (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same | 
| CA2707483A1              (en)* | 2007-11-30 | 2009-06-11 | Wolfgang Fraunhofer | Protein formulations and methods of making same | 
| US20130195888A1              (en)* | 2007-11-30 | 2013-08-01 | Abbvie | Ultrafiltration and diafiltration formulation methods for protein processing | 
| PE20091174A1              (en) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | LIQUID FORMULATION WITH HIGH CONCENTRATION OF ANTIBODY CONTENT | 
| US11197916B2              (en) | 2007-12-28 | 2021-12-14 | Takeda Pharmaceutical Company Limited | Lyophilized recombinant VWF formulations | 
| CN101952016A              (en) | 2007-12-28 | 2011-01-19 | 巴克斯特国际公司 | Reconstituted VWF formulation | 
| ES2406029T3              (en) | 2008-04-15 | 2013-06-05 | Grifols Therapeutics Inc. | Two-phase ultrafiltration / diafiltration | 
| CA2726824A1              (en) | 2008-05-01 | 2009-11-05 | Arecor Limited | Protein formulation | 
| US8188235B2              (en) | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses | 
| EP2328607A1              (en) | 2008-07-16 | 2011-06-08 | Arecor Limited | Stable formulation of a therapeutic protein | 
| AR074054A1              (en) | 2008-10-21 | 2010-12-22 | Baxter Healthcare Sa | PHARMACEUTICAL FORMULATIONS OF VIO WILLEBRAND RECOMBINANT LIOFILIZED FACTOR | 
| AU2009316592B2              (en)* | 2008-11-20 | 2016-01-07 | Genentech, Inc. | Therapeutic protein formulations | 
| US9056896B2              (en) | 2009-03-27 | 2015-06-16 | Asahi Kasei Medical Co., Ltd. | Method for removing viruses from high concentration monoclonal antibody solution | 
| US9345661B2              (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof | 
| AR078161A1              (en) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | VERY CONCENTRATED PHARMACEUTICAL FORMULATIONS OF AN ANTIBODY ANTI CD20. USE OF THE FORMULATION. TREATMENT METHOD | 
| CN104928336B              (en) | 2009-10-26 | 2020-05-08 | 弗·哈夫曼-拉罗切有限公司 | Method for producing glycosylated immunoglobulins | 
| CA2781467C              (en) | 2009-11-20 | 2015-10-13 | Biocon Limited | Formulations of antibody | 
| JO3417B1              (en)* | 2010-01-08 | 2019-10-20 | Regeneron Pharma | Stabilized formulations containing anti-interleukin-6 receptor (il-6r) antibodies | 
| US9795674B2              (en) | 2010-02-26 | 2017-10-24 | Novo Nordisk A/S | Stable antibody containing compositions | 
| LT2542257T              (en) | 2010-03-01 | 2017-11-27 | Bayer Healthcare Llc | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) | 
| EP2568960B1              (en) | 2010-05-10 | 2018-06-06 | Intas Pharmaceuticals Ltd. | Liquid formulation of polypeptides containing an fc domain of an immunoglobulin | 
| WO2011147921A1              (en) | 2010-05-28 | 2011-12-01 | Novo Nordisk A/S | Stable multi-dose compositions comprising an antibody and a preservative | 
| AU2015249186B2              (en)* | 2010-09-17 | 2018-03-22 | Baxalta GmbH | Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutal ph | 
| AR083034A1              (en)* | 2010-09-17 | 2013-01-30 | Baxter Int | STABILIZATION OF IMMUNOGLOBULINS AND OTHER PROTEINS THROUGH A WATERY FORMULATION WITH SODIUM CHLORIDE AT A WEAK ACID pH NEUTRAL | 
| PH12013500672A1              (en)* | 2010-10-06 | 2013-06-03 | Regeneron Pharma | Stabilized formulations containing anti-interleukin-4-receptor (il-4r) antibodies | 
| KR20220070586A              (en) | 2010-11-08 | 2022-05-31 | 제넨테크, 인크. | Subcutaneously administered anti-il-6 receptor antibody | 
| MX344727B              (en) | 2010-11-11 | 2017-01-05 | Abbvie Biotechnology Ltd | IMPROVED HIGH CONCENTRATION ANTI-TNFa ANTIBODY LIQUID FORMULATIONS. | 
| CA2833427C              (en) | 2011-04-20 | 2019-09-24 | Sandoz Ag | Stable pharmaceutical liquid formulations of the fusion protein tnfr:fc | 
| EP2735315B1              (en) | 2011-07-19 | 2019-10-02 | Chugai Seiyaku Kabushiki Kaisha | Stable protein-containing preparation containing argininamide or valinamide | 
| TWI589299B              (en) | 2011-10-11 | 2017-07-01 | 再生元醫藥公司 | Composition for treating rheumatoid arthritis and method of use thereof | 
| JP6110393B2              (en) | 2011-10-18 | 2017-04-05 | コヒラス・バイオサイエンシズ・インコーポレイテッド | Etanercept formulation stabilized by metal ions | 
| US10485869B2              (en) | 2011-10-18 | 2019-11-26 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with meglumine | 
| US9364542B2              (en) | 2011-10-28 | 2016-06-14 | Excelse Bio, Inc. | Protein formulations containing amino acids | 
| WO2013112438A1              (en) | 2012-01-23 | 2013-08-01 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-ang2 antibodies | 
| WO2013170977A1              (en) | 2012-05-14 | 2013-11-21 | Novo Nordisk A/S | Stabilised protein solutions | 
| HUE071647T2              (en) | 2012-05-18 | 2025-09-28 | Genentech Inc | High-concentration monoclonal antibody formulations | 
| AR092325A1              (en) | 2012-05-31 | 2015-04-15 | Regeneron Pharma | STABILIZED FORMULATIONS CONTAINING ANTI-DLL4 ANTIBODIES AND KIT | 
| US8613919B1              (en) | 2012-08-31 | 2013-12-24 | Bayer Healthcare, Llc | High concentration antibody and protein formulations | 
| US9592297B2              (en)* | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations | 
| EA029215B1              (en) | 2012-09-07 | 2018-02-28 | Кохерус Байосайенсис, Инк. | Stable aqueous formulations of adalimumab | 
| SMT201800163T1              (en) | 2012-09-11 | 2018-05-02 | Coherus Biosciences Inc | Correctly folded etanercept in high purity and excellent yield | 
| WO2014054744A1              (en)* | 2012-10-03 | 2014-04-10 | 協和発酵キリン株式会社 | Method for preventing polypeptide reduction by adding amino acid to liquid culture medium | 
| CA2913687C              (en) | 2013-07-04 | 2022-12-13 | F. Hoffmann-La Roche Ag | Interference-suppressed immunoassay to detect anti-drug antibodies in serum samples | 
| US9017678B1              (en) | 2014-07-15 | 2015-04-28 | Kymab Limited | Method of treating rheumatoid arthritis using antibody to IL6R | 
| IN2014MU01248A              (en) | 2014-04-02 | 2015-10-09 | Intas Pharmaceuticals Ltd |  | 
| WO2016128318A1              (en)* | 2015-02-09 | 2016-08-18 | Ucb Biopharma Sprl | Pharmaceutical formulation | 
| US11229702B1              (en) | 2015-10-28 | 2022-01-25 | Coherus Biosciences, Inc. | High concentration formulations of adalimumab | 
| WO2017147169A1              (en) | 2016-02-22 | 2017-08-31 | Ohio State Innovation Foundation | Chemoprevention using controlled-release formulations of anti-interleukin 6 agents, synthetic vitamin a analogues or metabolites, and estradiol metabolites | 
| US11071782B2              (en) | 2016-04-20 | 2021-07-27 | Coherus Biosciences, Inc. | Method of filling a container with no headspace | 
| WO2018060210A1              (en) | 2016-09-27 | 2018-04-05 | Ares Trading S.A. | Liquid pharmaceutical composition | 
| JP6884858B2              (en) | 2016-10-21 | 2021-06-09 | アムジエン・インコーポレーテツド | Pharmaceutical product and its manufacturing method | 
| DK3532029T3              (en) | 2016-10-31 | 2021-06-07 | Fresenius Kabi Deutschland Gmbh | Liquid pharmaceutical composition | 
| WO2018091729A2              (en) | 2016-11-21 | 2018-05-24 | Zaklady Farmaceutyczne Polpharma Sa | Aqueous pharmaceutical formulations | 
| PL3570882T3              (en)* | 2017-01-19 | 2022-02-07 | Bayer Pharma Aktiengesellschaft | Novel stable formulation for fxia antibodies | 
| JP7379159B2              (en)* | 2017-03-06 | 2023-11-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Aqueous anti-PD-L1 antibody preparation | 
| CN110603057A              (en) | 2017-03-17 | 2019-12-20 | 俄亥俄州创新基金会 | Nanoparticles for delivery of chemopreventive agents | 
| US20220071901A1              (en)* | 2017-11-30 | 2022-03-10 | Bio-Thera Solutions, Ltd. | A liquid formulation of humanized antibody for treating il-6-mediated diseases | 
| JP6903617B2              (en)* | 2018-09-19 | 2021-07-14 | 株式会社東芝 | How to determine the molecular probe | 
| CN114206442A              (en) | 2019-01-31 | 2022-03-18 | 赛诺菲生物技术公司 | Anti-IL-6 receptor antibody for the treatment of juvenile idiopathic arthritis | 
| EP3947737A2              (en) | 2019-04-02 | 2022-02-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions | 
| KR20230061198A              (en) | 2019-06-04 | 2023-05-08 | 사노피 바이오테크놀로지 | Compositions and methods for treating pain in a subject with rheumatoid arthritis | 
| KR20230010239A              (en)* | 2020-05-11 | 2023-01-18 | 메디뮨 리미티드 | Formulations of Anti-IL-33 Antibodies |