Movatterモバイル変換


[0]ホーム

URL:


AU2001264946A1 - Bispecific immunoglobulin-like antigen binding proteins and method of production - Google Patents

Bispecific immunoglobulin-like antigen binding proteins and method of production

Info

Publication number
AU2001264946A1
AU2001264946A1AU2001264946AAU6494601AAU2001264946A1AU 2001264946 A1AU2001264946 A1AU 2001264946A1AU 2001264946 AAU2001264946 AAU 2001264946AAU 6494601 AAU6494601 AAU 6494601AAU 2001264946 A1AU2001264946 A1AU 2001264946A1
Authority
AU
Australia
Prior art keywords
production
antigen binding
binding proteins
bispecific immunoglobulin
bispecific
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001264946A
Inventor
Zhenping Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ImClone LLC
Original Assignee
ImClone Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ImClone Systems IncfiledCriticalImClone Systems Inc
Publication of AU2001264946A1publicationCriticalpatent/AU2001264946A1/en
Abandonedlegal-statusCriticalCurrent

Links

Classifications

Landscapes

AU2001264946A2000-05-242001-05-24Bispecific immunoglobulin-like antigen binding proteins and method of productionAbandonedAU2001264946A1 (en)

Applications Claiming Priority (3)

Application NumberPriority DateFiling DateTitle
US20674900P2000-05-242000-05-24
US60/206,7492000-05-24
PCT/US2001/016924WO2001090192A2 (en)2000-05-242001-05-24Bispecific immunoglobulin-like antigen binding proteins and method of production

Publications (1)

Publication NumberPublication Date
AU2001264946A1true AU2001264946A1 (en)2001-12-03

Family

ID=22767777

Family Applications (1)

Application NumberTitlePriority DateFiling Date
AU2001264946AAbandonedAU2001264946A1 (en)2000-05-242001-05-24Bispecific immunoglobulin-like antigen binding proteins and method of production

Country Status (6)

CountryLink
US (2)US20020103345A1 (en)
EP (1)EP1299419A2 (en)
JP (1)JP2004511430A (en)
AU (1)AU2001264946A1 (en)
CA (1)CA2409991A1 (en)
WO (1)WO2001090192A2 (en)

Families Citing this family (264)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US20030108545A1 (en)*1994-02-102003-06-12Patricia RockwellCombination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist
US6448077B1 (en)*1994-02-102002-09-10Imclone Systems, Inc.Chimeric and humanized monoclonal antibodies specific to VEGF receptors
AU2469299A (en)*1998-01-231999-08-09Cornell Research Foundation Inc.Purified populations of stem cells
US7754208B2 (en)2001-01-172010-07-13Trubion Pharmaceuticals, Inc.Binding domain-immunoglobulin fusion proteins
EP1515707A4 (en)*2001-06-202005-10-19Imclone Systems Inc METHODS OF TREATING ATHEROSCLEROSIS AND OTHER INFLAMMATORY DISEASES
WO2003002144A1 (en)*2001-06-262003-01-09Imclone Systems IncorporatedBispecific antibodies that bind to vegf receptors
US20060073141A1 (en)*2001-06-282006-04-06Domantis LimitedCompositions and methods for treating inflammatory disorders
US20050271663A1 (en)*2001-06-282005-12-08Domantis LimitedCompositions and methods for treating inflammatory disorders
DE60237282D1 (en)*2001-06-282010-09-23Domantis Ltd DOUBLE-SPECIFIC LIGAND AND ITS USE
ES2299590T3 (en)*2001-08-102008-06-01Imclone Systems, Inc. MEDICAL USE OF MOTHER CELLS THAT EXPRESS VEGFR-1.NG VEGFR-1.
ES2466377T3 (en)2001-08-232014-06-10Rsr Limited Epitopic regions of a thyrotropin receptor (TSH), uses thereof and antibodies thereto
EP2075256A2 (en)2002-01-142009-07-01William HermanMultispecific binding molecules
ATE510561T1 (en)2002-03-042011-06-15Imclone Llc KDR-SPECIFIC HUMAN ANTIBODIES AND THEIR USE
ATE328906T1 (en)*2002-06-282006-06-15Domantis Ltd DUAL-SPECIFIC LIGANDS WITH INCREASED HALF-LIFE
US7696320B2 (en)2004-08-242010-04-13Domantis LimitedLigands that have binding specificity for VEGF and/or EGFR and methods of use therefor
US9321832B2 (en)*2002-06-282016-04-26Domantis LimitedLigand
KR20050057631A (en)*2002-10-102005-06-16메르크 파텐트 게엠베하Bispecific anti-erb-b antibodies and their use in tumor therapy
EP1578801A2 (en)*2002-12-272005-09-28Domantis LimitedDual specific single domain antibodies specific for a ligand and for the receptor of the ligand
JP2007500248A (en)2003-06-092007-01-11ワクサル,サムエル Method for inhibiting receptor tyrosine kinase by extracellular antagonist and intracellular antagonist
JPWO2005035754A1 (en)2003-10-142006-12-21中外製薬株式会社 Bispecific antibodies that replace functional proteins
EP1709081B1 (en)*2004-01-162011-04-06Regeneron Pharmaceuticals, Inc.Fusion polypeptides capable of activating receptors
US8298532B2 (en)2004-01-162012-10-30Regeneron Pharmaceuticals, Inc.Fusion polypeptides capable of activating receptors
DE602005027673D1 (en)*2004-03-052011-06-09Vegenics Pty Ltd MATERIALS AND METHODS FOR GROWTH FACTORY BONDING CONSTRUCTS
US20050282233A1 (en)*2004-03-052005-12-22Ludwig Institute For Cancer ResearchMultivalent antibody materials and methods for VEGF/PDGF family of growth factors
EP1732946B1 (en)*2004-03-082011-07-27ZymoGenetics, Inc.Dimeric fusion proteins and materials and methods for producing them
EP1778270A4 (en)*2004-05-052009-09-02Merrimack Pharmaceuticals Inc BISPECIFIC BINDING AGENTS FOR MODULATION OF BIOLOGICAL ACTIVITY
EP1773881A4 (en)*2004-05-132008-08-06Imclone Systems IncInhibition of macrophage-stimulating protein receptor (ron)
WO2005118642A2 (en)2004-06-012005-12-15Domantis LimitedBispecific fusion antibodies with enhanced serum half-life
NZ582684A (en)*2004-06-182011-05-27Ambrx IncUse of an antibody or binding fragment thereof comprising a non naturally encoded amino acid coupled to a linker
US7563443B2 (en)2004-09-172009-07-21Domantis LimitedMonovalent anti-CD40L antibody polypeptides and compositions thereof
US7972596B2 (en)*2004-11-182011-07-05Imclone LlcAntibodies against vascular endothelial growth factor receptor-1
PL1752471T3 (en)*2005-01-052009-04-30F Star Biotechnologische Forschungs Und Entw M B HSynthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
EP1866339B8 (en)*2005-03-252021-12-01GITR, Inc.Gitr binding molecules and uses therefor
DK3050963T3 (en)2005-03-312019-12-09Chugai Pharmaceutical Co Ltd Process for producing polypeptide by arrangement control
US20120237442A1 (en)*2005-04-062012-09-20Ibc Pharmaceuticals, Inc.Design and Construction of Novel Multivalent Antibodies
EP2505205A1 (en)2005-06-172012-10-03Imclone LLCAnti-PDGFR Alpha Antibodies
AU2006261127B2 (en)*2005-06-172012-03-15Merck Sharp & Dohme Corp.ILT3 binding molecules and uses therefor
HUE026303T2 (en)2005-07-252016-06-28Emergent Product Dev SeattleB-cell reduction using CD37-specific and CD20-specific binding molecules
JP2012228248A (en)*2005-08-192012-11-22Abbott LabDual variable domain immunoglobulin and use thereof
US7612181B2 (en)2005-08-192009-11-03Abbott LaboratoriesDual variable domain immunoglobulin and uses thereof
NZ597168A (en)*2005-08-192013-07-26Abbott LabDual variable domain immunoglobin and uses thereof
BRPI0619225A2 (en)*2005-12-012017-11-07Domantis Ltd domain antibody monomer, ligand, isolated and recombinant nucleic acids, vector, host cell, method for producing a ligand dab monomer, pharmaceutical composition, drug delivery device, use of a domain antibody monomer, and, method to treat an inflammatory disease, arthritis or respiratory disease
JP5198289B2 (en)2006-02-032013-05-15イムクローン・リミテッド・ライアビリティ・カンパニー IGF-IR antagonists as adjuvants for the treatment of prostate cancer
SG170799A1 (en)2006-03-282011-05-30Biogen Idec IncAnti-igf-ir antibodies and uses thereof
EP2009101B1 (en)2006-03-312017-10-25Chugai Seiyaku Kabushiki KaishaAntibody modification method for purifying bispecific antibody
IN2014DN10515A (en)2006-03-312015-08-21Chugai Pharmaceutical Co Ltd
NZ573646A (en)2006-06-122012-04-27Wyeth LlcSingle-chain multivalent binding proteins with effector function
JP5597793B2 (en)*2006-06-192014-10-01メルク・シャープ・アンド・ドーム・コーポレーション ILT3-binding molecules and uses thereof
AT503889B1 (en)2006-07-052011-12-15Star Biotechnologische Forschungs Und Entwicklungsges M B H F MULTIVALENT IMMUNE LOBULINE
MX2009011226A (en)2007-04-172010-04-01Imclone LlcPdgfrbeta-specific inhibitors.
BRPI0812398A2 (en)*2007-06-062019-09-24Domantis Ltd anti-vegf immunoglobulin single variable domain, anti-vegf antagonist, protease resistant immunoglobulin simple variable domain, use of vegf antagonist, method for oral or drug delivery to a patient's gi tract or lung or lung tissue or a patient's eye, pulmonary dispensing device, oral formulation, double specific ligand, isolated or recombinant nucleic acid, vector, host cell, method for producing polypeptide, pharmaceutical composition, polypeptide, and fusion protein.
KR100883430B1 (en)*2007-06-132009-02-12한국생명공학연구원 Human monoclonal antibodies neutralizing vascular endothelial growth factor receptors and uses thereof
PL3241842T3 (en)2007-06-262024-06-10F-Star Therapeutics LimitedDisplay of binding agents
ES2591281T3 (en)*2007-07-122016-11-25Gitr, Inc. Combination therapies that employ GITR binding molecules
US20090155275A1 (en)*2007-07-312009-06-18Medimmune, LlcMultispecific epitope binding proteins and uses thereof
US20090130105A1 (en)*2007-08-282009-05-21Biogen Idec Ma Inc.Compositions that bind multiple epitopes of igf-1r
CN106519025B (en)2007-09-262021-04-23中外制药株式会社Method for changing isoelectric point of antibody by using amino acid substitution of CDR
EP2535351A3 (en)2007-09-262013-04-03UCB Pharma S.A.Dual specificity antibody fusions
EP2050764A1 (en)*2007-10-152009-04-22sanofi-aventisNovel polyvalent bispecific antibody format and uses thereof
AR069393A1 (en)*2007-11-212010-01-20Imclone Systems Inc INHIBITION OF THE RECEIVER FOR MACROFAGO STIMULATING PROTEIN (RON) AND METHODS FOR THE TREATMENT OF THE SAME
US9266967B2 (en)2007-12-212016-02-23Hoffmann-La Roche, Inc.Bivalent, bispecific antibodies
US20090162359A1 (en)2007-12-212009-06-25Christian KleinBivalent, bispecific antibodies
EP2604279A1 (en)*2008-03-272013-06-19ZymoGenetics, Inc.Compositions and methods for inhibiting PDGFRBETA and VEGF-A
NZ588671A (en)2008-04-112012-11-30Emergent Product Dev SeattleCd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
EP2113255A1 (en)2008-05-022009-11-04f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H.Cytotoxic immunoglobulin
EP2346526A2 (en)2008-09-222011-07-27Massachusetts Institute of TechnologyCompositions of and methods of using ligand dimers
ES2620603T3 (en)*2008-09-262017-06-29Ucb Biopharma Sprl Biological products
CA2779436A1 (en)*2008-10-312010-05-06Biogen Idec Ma Inc.Light targeting molecules and uses thereof
WO2010096394A2 (en)2009-02-172010-08-26Redwood Biosciences, Inc.Aldehyde-tagged protein-based drug carriers and methods of use
AU2010230563A1 (en)2009-04-022011-09-22Roche Glycart AgMultispecific antibodies comprising full length antibodies and single chain Fab fragments
ES2537100T3 (en)2009-04-072015-06-02Roche Glycart Ag Trivalent bispecific antibodies
US9676845B2 (en)2009-06-162017-06-13Hoffmann-La Roche, Inc.Bispecific antigen binding proteins
WO2011028952A1 (en)2009-09-022011-03-10Xencor, Inc.Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
BR112012004823B1 (en)2009-09-032021-11-30Merck Sharp & Dohme Corp ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF, USE OF AN ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF, AND PHARMACEUTICAL COMPOSITION
SG10201408401RA (en)2009-09-162015-01-29Genentech IncCoiled coil and/or tether containing protein complexes and uses thereof
WO2011062862A1 (en)2009-11-172011-05-26Centocor Ortho Biotech Inc.Improved bacterial membrane protein secrection
EP2501808B1 (en)2009-11-172016-04-13Janssen Biotech, Inc.Display of disulfide linked dimeric proteins on filamentous phage
WO2011119836A1 (en)2010-03-242011-09-29Massachusetts Institute Of TechnologyMethods and compositions for cardioprotection and cardioregeneration
TW201138821A (en)2010-03-262011-11-16Roche Glycart AgBispecific antibodies
CN105585630B (en)2010-07-292020-09-15Xencor公司Antibodies with modified isoelectric points
CN103068846B9 (en)2010-08-242016-09-28弗·哈夫曼-拉罗切有限公司Bispecific antibodies comprising disulfide-stabilized Fv fragments
CN103068847B (en)2010-08-242019-05-07罗切格利卡特公司Activable bispecific antibody
SI2644698T1 (en)2010-11-172018-05-31Chugai Seiyaku Kabushiki KaishaMulti-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii
CN103459422A (en)2010-11-242013-12-18葛兰素集团有限公司Multispecific antigen binding proteins targeting HGF
PT2647707T (en)2010-11-302018-11-15Chugai Pharmaceutical Co LtdCytotoxicity-inducing therapeutic agent
JP5766296B2 (en)2010-12-232015-08-19エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Polypeptide-polynucleotide complexes and their use in targeted delivery of effector components
AU2012205301B2 (en)2011-01-142017-01-05Redwood Bioscience, Inc.Aldehyde-tagged immunoglobulin polypeptides and method of use thereof
WO2012116927A1 (en)2011-02-282012-09-07F. Hoffmann-La Roche AgMonovalent antigen binding proteins
KR101638224B1 (en)2011-02-282016-07-08에프. 호프만-라 로슈 아게Antigen binding proteins
PL3235508T3 (en)2011-03-162021-07-12SanofiCompositions comprising a dual v region antibody-like protein
US10130081B2 (en)2011-08-052018-11-20Regeneron Pharmaceuticals, Inc.Humanized universal light chain mice
US10851178B2 (en)2011-10-102020-12-01Xencor, Inc.Heterodimeric human IgG1 polypeptides with isoelectric point modifications
US11851476B2 (en)2011-10-312023-12-26Chugai Seiyaku Kabushiki KaishaAntigen-binding molecule having regulated conjugation between heavy-chain and light-chain
CA2854806A1 (en)2011-11-072013-05-16Medimmune, LlcMultispecific and multivalent binding proteins and uses thereof
EP2812357B1 (en)2012-02-102020-11-04F.Hoffmann-La Roche AgSingle-chain antibodies and other heteromultimers
CN104395339A (en)2012-06-272015-03-04弗·哈夫曼-拉罗切有限公司Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof
CN104411718B (en)2012-06-272018-04-24弗·哈夫曼-拉罗切有限公司It is used to prepare method of antibody Fc district conjugate of at least one binding entity comprising specific binding target and application thereof
US9682143B2 (en)2012-08-142017-06-20Ibc Pharmaceuticals, Inc.Combination therapy for inducing immune response to disease
US20150231241A1 (en)2012-08-142015-08-20Ibc Pharmaceuticals, Inc.Combination therapy for inducing immune response to disease
US10968276B2 (en)2013-03-122021-04-06Xencor, Inc.Optimized anti-CD3 variable regions
US10131710B2 (en)2013-01-142018-11-20Xencor, Inc.Optimized antibody variable regions
US11053316B2 (en)2013-01-142021-07-06Xencor, Inc.Optimized antibody variable regions
US10487155B2 (en)2013-01-142019-11-26Xencor, Inc.Heterodimeric proteins
JP6618362B2 (en)2013-01-142019-12-11ゼンコア インコーポレイテッド Novel heterodimeric protein
US9701759B2 (en)2013-01-142017-07-11Xencor, Inc.Heterodimeric proteins
US9605084B2 (en)2013-03-152017-03-28Xencor, Inc.Heterodimeric proteins
AU2014207549B2 (en)2013-01-152018-12-06Xencor, Inc.Rapid clearance of antigen complexes using novel antibodies
EP2970486B1 (en)2013-03-152018-05-16Xencor, Inc.Modulation of t cells with bispecific antibodies and fc fusions
US10858417B2 (en)2013-03-152020-12-08Xencor, Inc.Heterodimeric proteins
US10106624B2 (en)2013-03-152018-10-23Xencor, Inc.Heterodimeric proteins
US10519242B2 (en)2013-03-152019-12-31Xencor, Inc.Targeting regulatory T cells with heterodimeric proteins
WO2015046467A1 (en)2013-09-272015-04-02中外製薬株式会社Method for producing polypeptide heteromultimer
KR20160044060A (en)2013-10-112016-04-22에프. 호프만-라 로슈 아게Multispecific domain exchanged common variable light chain antibodies
CA2933707A1 (en)2013-12-202015-06-25Fred Hutchinson Cancer Research CenterTagged chimeric effector molecules and receptors thereof
JOP20200094A1 (en)2014-01-242017-06-16Dana Farber Cancer Inst Inc Antibody Molecules of PD-1 and Their Uses
JOP20200096A1 (en)2014-01-312017-06-16Children’S Medical Center CorpAntibody molecules to tim-3 and uses thereof
TWI852057B (en)2014-03-142024-08-11瑞士商諾華公司Antibody molecules to lag-3 and uses thereof
CN106163547A (en)2014-03-152016-11-23诺华股份有限公司Use Chimeric antigen receptor treatment cancer
PL3122781T3 (en)2014-03-282020-06-15Xencor, Inc.Bispecific antibodies that bind to cd38 and cd3
ES2900898T3 (en)2014-04-072022-03-18Chugai Pharmaceutical Co Ltd Bispecific immunoactivating antibodies
CN106459954A (en)2014-05-132017-02-22中外制药株式会社T cell-redirected antigen-binding molecule for cells having immunosuppression function
GB201411320D0 (en)2014-06-252014-08-06Ucb Biopharma SprlAntibody construct
CA2954934C (en)2014-06-302023-09-26Glykos Finland OyDrug derivative and conjugates
JP7054622B2 (en)2014-07-212022-04-14ノバルティス アーゲー Treatment of cancer with humanized anti-BCMA chimeric antigen receptor
WO2016014553A1 (en)2014-07-212016-01-28Novartis AgSortase synthesized chimeric antigen receptors
WO2016014530A1 (en)2014-07-212016-01-28Novartis AgCombinations of low, immune enhancing. doses of mtor inhibitors and cars
MX390943B (en)2014-07-212025-03-21Novartis Ag CD33 CHIMERATIC ANTIGEN RECEPTORS AND THEIR USES.
WO2016019300A1 (en)2014-07-312016-02-04Novartis AgSubset-optimized chimeric antigen receptor-containing t-cells
US9815901B2 (en)2014-08-192017-11-14Novartis AgTreatment of cancer using a CD123 chimeric antigen receptor
CA2958200A1 (en)2014-08-142016-02-18Novartis AgTreatment of cancer using a gfr alpha-4 chimeric antigen receptor
PL3194443T3 (en)2014-09-172022-01-31Novartis AgTargeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
TWI701435B (en)2014-09-262020-08-11日商中外製藥股份有限公司 Method to determine the reactivity of FVIII
TWI700300B (en)2014-09-262020-08-01日商中外製藥股份有限公司 Antibodies that neutralize substances with the function of FVIII coagulation factor (FVIII)
MA40764A (en)2014-09-262017-08-01Chugai Pharmaceutical Co Ltd THERAPEUTIC AGENT INDUCING CYTOTOXICITY
CU20170052A7 (en)2014-10-142017-11-07Dana Farber Cancer Inst Inc ANTIBODY MOLECULES THAT JOIN PD-L1
EA201791139A1 (en)2014-11-262018-04-30Ксенкор, Инк. HETERODIMERNYE ANTIBODIES THAT BIND CD3 AND TUMOR ANTIGENS
US10259887B2 (en)2014-11-262019-04-16Xencor, Inc.Heterodimeric antibodies that bind CD3 and tumor antigens
SG11201704274QA (en)2014-11-262017-06-29Xencor IncHeterodimeric antibodies that bind cd3 and cd38
WO2016090034A2 (en)2014-12-032016-06-09Novartis AgMethods for b cell preconditioning in car therapy
JP6721590B2 (en)2014-12-032020-07-15エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Multispecific antibody
EP3237449A2 (en)2014-12-222017-11-01Xencor, Inc.Trispecific antibodies
WO2016141387A1 (en)2015-03-052016-09-09Xencor, Inc.Modulation of t cells with bispecific antibodies and fc fusions
US11142587B2 (en)2015-04-012021-10-12Chugai Seiyaku Kabushiki KaishaMethod for producing polypeptide hetero-oligomer
MX2017012939A (en)2015-04-082018-05-22Novartis Ag CD20 THERAPIES, CD22 THERAPIES AND COMBINATION THERAPIES WITH A CELL THAT EXPRESSES AN ANTIGEN (CAR) CHEMICAL RECEIVER OF CD19.
EP3286211A1 (en)2015-04-232018-02-28Novartis AGTreatment of cancer using chimeric antigen receptor and protein kinase a blocker
WO2016176652A2 (en)*2015-04-292016-11-03Fred Hutchinson Cancer Research CenterModified stem cells and uses thereof
WO2017019896A1 (en)2015-07-292017-02-02Novartis AgCombination therapies comprising antibody molecules to pd-1
EP3878465A1 (en)2015-07-292021-09-15Novartis AGCombination therapies comprising antibody molecules to tim-3
PT3317301T (en)2015-07-292021-07-09Novartis AgCombination therapies comprising antibody molecules to lag-3
JP7002446B2 (en)2015-09-212022-03-04アプティーボ リサーチ アンド デベロップメント エルエルシー CD3 binding polypeptide
EP3371217A1 (en)*2015-11-082018-09-12H. Hoffnabb-La Roche AgMethods of screening for multispecific antibodies
WO2017086367A1 (en)2015-11-182017-05-26中外製薬株式会社Combination therapy using t cell redirection antigen binding molecule against cell having immunosuppressing function
EP3378488A4 (en)2015-11-182019-10-30Chugai Seiyaku Kabushiki KaishaMethod for enhancing humoral immune response
US11623957B2 (en)2015-12-072023-04-11Xencor, Inc.Heterodimeric antibodies that bind CD3 and PSMA
EP3389712B1 (en)2015-12-172024-04-10Novartis AGAntibody molecules to pd-1 and uses thereof
KR20180094977A (en)2015-12-172018-08-24노파르티스 아게 Combinations of c-Met inhibitors and antibody molecules for PD-1 and uses thereof
JP6954842B2 (en)2015-12-252021-10-27中外製薬株式会社 Antibodies with enhanced activity and methods for modifying them
EP3398965A4 (en)2015-12-282019-09-18Chugai Seiyaku Kabushiki KaishaMethod for promoting efficiency of purification of fc region-containing polypeptide
EP3405492B1 (en)2016-01-212020-10-21Novartis AGMultispecific molecules targeting cll-1
CN105481981B (en)*2016-01-272019-03-19中国人民解放军第二军医大学Target VEGF bispecific antibody and application thereof
WO2017149515A1 (en)2016-03-042017-09-08Novartis AgCells expressing multiple chimeric antigen receptor (car) molecules and uses therefore
MX2018010988A (en)2016-03-142019-01-21Chugai Pharmaceutical Co LtdCell injury inducing therapeutic drug for use in cancer therapy.
WO2017165683A1 (en)2016-03-232017-09-28Novartis AgCell secreted minibodies and uses thereof
IL262321B2 (en)2016-04-152024-09-01Novartis AgCompositions and methods for selective protein expression
JP2019515677A (en)2016-04-262019-06-13アール.ピー.シェーラー テクノロジーズ エルエルシー Antibody conjugates and methods of making and using the same
US20210177896A1 (en)2016-06-022021-06-17Novartis AgTherapeutic regimens for chimeric antigen receptor (car)- expressing cells
US10787518B2 (en)2016-06-142020-09-29Xencor, Inc.Bispecific checkpoint inhibitor antibodies
RU2019102008A (en)2016-06-282020-07-28Ксенкор, Инк. HETERODIMERIC ANTIBODIES THAT BIND TYPE 2 SOMATOSTATIN RECEPTOR
CA3030837A1 (en)2016-07-152018-01-18Novartis AgTreatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor
CN118021943A (en)2016-07-282024-05-14诺华股份有限公司Combination therapy of chimeric antigen receptor and PD-1 inhibitor
MX2019001469A (en)2016-08-012019-10-02Novartis AgTreatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule.
US10793632B2 (en)2016-08-302020-10-06Xencor, Inc.Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
BR112019003989A2 (en)2016-09-062019-05-28Chugai Pharmaceutical Co Ltd methods of using a bispecific antibody that recognizes coagulation factor ix and / or activated coagulation factor ix and coagulation factor x and / or coagulation factor x activated
CN117866991A (en)2016-10-072024-04-12诺华股份有限公司Chimeric antigen receptor for the treatment of cancer
PE20191033A1 (en)2016-10-142019-08-05Xencor Inc HETERODIMERIC FC FUSION PROTEINS IL 15 / IL 15R (alpha)
EP4043485A1 (en)2017-01-262022-08-17Novartis AGCd28 compositions and methods for chimeric antigen receptor therapy
JOP20190189A1 (en)2017-02-022019-08-01Amgen Res Munich GmbhLow ph pharmaceutical composition comprising t cell engaging antibody constructs
CA3221995C (en)2017-02-082024-05-28Dragonfly Therapeutics, Inc.Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
WO2018152518A1 (en)2017-02-202018-08-23Adimab, LlcProteins binding her2, nkg2d and cd16
WO2018160731A1 (en)2017-02-282018-09-07Novartis AgShp inhibitor compositions and uses for chimeric antigen receptor therapy
WO2018201056A1 (en)2017-04-282018-11-01Novartis AgCells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
WO2018201051A1 (en)2017-04-282018-11-01Novartis AgBcma-targeting agent, and combination therapy with a gamma secretase inhibitor
EP3635125A4 (en)*2017-06-072022-03-02Antibody Biopharm, Inc. GUIDED COMBINATIONAL THERAPEUTIC ANTIBODIES
WO2018237157A1 (en)2017-06-222018-12-27Novartis Ag CD73 BINDING ANTIBODY MOLECULES AND USES THEREOF
JP2020525483A (en)2017-06-272020-08-27ノバルティス アーゲー Dosing regimens for anti-TIM-3 antibodies and uses thereof
JP2020529832A (en)2017-06-302020-10-15ゼンコア インコーポレイテッド Targeted heterodimer Fc fusion protein containing IL-15 / IL-15Rα and antigen binding domain
TWI820031B (en)2017-07-112023-11-01美商坎伯斯治療有限責任公司Agonist antibodies that bind human cd137 and uses thereof
KR20250025039A (en)2017-07-202025-02-20노파르티스 아게Dosage regimens of anti-lag-3 antibodies and uses thereof
WO2019065795A1 (en)2017-09-292019-04-04中外製薬株式会社Multispecific antigen-binding molecule having blood coagulation factor viii (fviii) cofactor function-substituting activity, and pharmaceutical formulation containing said molecule as active ingredient
WO2019089753A2 (en)2017-10-312019-05-09Compass Therapeutics LlcCd137 antibodies and pd-1 antagonists and uses thereof
EP3706793A1 (en)2017-11-082020-09-16Xencor, Inc.Bispecific and monospecific antibodies using novel anti-pd-1 sequences
US10981992B2 (en)2017-11-082021-04-20Xencor, Inc.Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
JP2021503478A (en)2017-11-162021-02-12ノバルティス アーゲー Combination treatment
WO2019100052A2 (en)2017-11-202019-05-23Compass Therapeutics LlcCd137 antibodies and tumor antigen-targeting antibodies and uses thereof
KR102722731B1 (en)2017-12-192024-10-25젠코어 인코포레이티드 Engineered IL-2 FC fusion protein
EP3737692A4 (en)2018-01-092021-09-29Elstar Therapeutics, Inc. CALRETICULIN-BINDING CONSTRUCTS AND GENERALLY MODIFIED T-CELLS FOR THE TREATMENT OF DISEASES
EP3746116A1 (en)2018-01-312020-12-09Novartis AGCombination therapy using a chimeric antigen receptor
BR112020016190A2 (en)2018-02-082020-12-15Dragonfly Therapeutics, Inc. ANTIBODY VARIABLE DOMAINS DIRECTING THE NKG2D RECEIVER
SG11202007945UA (en)2018-02-202020-09-29Dragonfly Therapeutics IncMulti-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use
US12152073B2 (en)2018-03-142024-11-26Marengo Therapeutics, Inc.Multifunctional molecules that bind to calreticulin and uses thereof
EP3773911A2 (en)2018-04-042021-02-17Xencor, Inc.Heterodimeric antibodies that bind fibroblast activation protein
US20210147547A1 (en)2018-04-132021-05-20Novartis AgDosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof
JP2021521784A (en)2018-04-182021-08-30ゼンコア インコーポレイテッド PD-1 targeted heterodimer fusion proteins containing IL-15 / IL-15RaFc fusion proteins and PD-1 antigen binding domains and their use
CN112437777A (en)2018-04-182021-03-02Xencor股份有限公司TIM-3 targeting heterodimeric fusion proteins comprising an IL-15/IL-15RA Fc fusion protein and a TIM-3 antigen binding domain
US20210047405A1 (en)2018-04-272021-02-18Novartis AgCar t cell therapies with enhanced efficacy
WO2019226658A1 (en)2018-05-212019-11-28Compass Therapeutics LlcMultispecific antigen-binding compositions and methods of use
JP2021525243A (en)2018-05-212021-09-24コンパス セラピューティクス リミテッド ライアビリティ カンパニー Compositions and Methods for Promoting Killing of Target Cells by NK Cells
EP3801769A1 (en)2018-05-252021-04-14Novartis AGCombination therapy with chimeric antigen receptor (car) therapies
WO2019232244A2 (en)2018-05-312019-12-05Novartis AgAntibody molecules to cd73 and uses thereof
JP7438988B2 (en)2018-06-132024-02-27ノバルティス アーゲー BCMA chimeric antigen receptor and its use
CN112654394A (en)2018-06-192021-04-13阿塔盖有限责任公司Antibody molecules against complement component 5 and uses thereof
SG11202013138RA (en)2018-07-022021-01-28Amgen IncAnti-steap1 antigen-binding protein
AU2019297451A1 (en)2018-07-032021-01-28Marengo Therapeutics, Inc.Anti-TCR antibody molecules and uses thereof
AR116109A1 (en)2018-07-102021-03-31Novartis Ag DERIVATIVES OF 3- (5-AMINO-1-OXOISOINDOLIN-2-IL) PIPERIDINE-2,6-DIONA AND USES OF THE SAME
WO2020021465A1 (en)2018-07-252020-01-30Advanced Accelerator Applications (Italy) S.R.L.Method of treatment of neuroendocrine tumors
EA202091888A1 (en)2018-08-082020-10-23Драгонфлай Терапьютикс, Инк. VARIABLE ANTIBODY DOMAINS TARGETED ON THE NKG2D RECEPTOR
CA3115096A1 (en)2018-10-032020-04-09Xencor, Inc.Il-12 heterodimeric fc-fusion proteins
CN113166269B (en)2018-11-132025-01-07指南针制药有限责任公司 Multispecific binding constructs against checkpoint molecules and their uses
CA3123511A1 (en)2018-12-202020-06-25Novartis AgDosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
KR20210106483A (en)2018-12-202021-08-30노파르티스 아게 Extended low-dose regimen for MDM2 inhibitors
CN111378045B (en)*2018-12-282022-08-02长春金赛药业有限责任公司Bivalent and bispecific antibody, preparation method thereof, encoding gene, host cell and composition
US10871640B2 (en)2019-02-152020-12-22Perkinelmer Cellular Technologies Germany GmbhMethods and systems for automated imaging of three-dimensional objects
WO2020165833A1 (en)2019-02-152020-08-20Novartis Ag3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
JP7488826B2 (en)2019-02-152024-05-22ノバルティス アーゲー Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
EP3927371A1 (en)2019-02-222021-12-29Novartis AGCombination therapies of egfrviii chimeric antigen receptors and pd-1 inhibitors
SG11202109406TA (en)2019-03-012021-09-29Xencor IncHeterodimeric antibodies that bind enpp3 and cd3
CA3135430A1 (en)2019-03-292020-10-08Atarga, LlcAnti fgf23 antibody
TW202128166A (en)2019-10-212021-08-01瑞士商諾華公司Combination therapies
MX2022004769A (en)2019-10-212022-05-16Novartis AgTim-3 inhibitors and uses thereof.
TW202134264A (en)2019-11-262021-09-16瑞士商諾華公司Chimeric antigen receptors and uses thereof
CN115052662A (en)2019-12-202022-09-13诺华股份有限公司Use of anti-TGF-beta antibodies and checkpoint inhibitors for treating proliferative diseases
CN114980902A (en)2020-01-172022-08-30诺华股份有限公司Combination comprising a TIM-3 inhibitor and a hypomethylated drug for the treatment of myelodysplastic syndrome or chronic myelomonocytic leukemia
WO2021146636A1 (en)2020-01-172021-07-22Becton, Dickinson And CompanyMethods and compositions for single cell secretomics
JP2023515211A (en)2020-02-272023-04-12ノバルティス アーゲー Method for producing chimeric antigen receptor-expressing cells
KR20230004798A (en)2020-04-292023-01-06암젠 인크 pharmaceutical formulation
JP2023524444A (en)2020-04-292023-06-12アムジェン インコーポレイテッド Pharmaceutical formulation
CN115836088A (en)2020-05-062023-03-21蜻蜓疗法股份有限公司NKG 2D-, CD 16-and CLEC 12A-binding proteins
US11919956B2 (en)2020-05-142024-03-05Xencor, Inc.Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3
MX2022015852A (en)2020-06-232023-01-24Novartis AgDosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6- dione derivatives.
JP2023534214A (en)2020-07-162023-08-08ノバルティス アーゲー Anti-betacellulin antibodies, fragments thereof, and multispecific binding molecules
WO2022026592A2 (en)2020-07-282022-02-03Celltas Bio, Inc.Antibody molecules to coronavirus and uses thereof
CN116134027B (en)2020-08-032025-01-24诺华股份有限公司 Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
AU2021329378A1 (en)2020-08-192023-03-23Xencor, Inc.Anti-CD28 compositions
EP4200333A1 (en)2020-08-242023-06-28Amgen Inc.Pharmaceutical formulation comprising a bite, bispecific antibody, and methionine
US20230321285A1 (en)2020-08-312023-10-12Advanced Accelerator Applications International SaMethod of treating psma-expressing cancers
WO2022043558A1 (en)2020-08-312022-03-03Advanced Accelerator Applications International SaMethod of treating psma-expressing cancers
US20240002509A1 (en)2020-11-062024-01-04Novartis AgANTIBODY Fc VARIANTS
KR20230107617A (en)2020-11-132023-07-17노파르티스 아게 Combination therapy using chimeric antigen receptor (CAR)-expressing cells
JP2024505049A (en)2021-01-292024-02-02ノバルティス アーゲー Administration modes for anti-CD73 and anti-ENTPD2 antibodies and their uses
MX2023010499A (en)2021-03-092023-09-18Xencor IncHeterodimeric antibodies that bind cd3 and cldn6.
JP2024509274A (en)2021-03-102024-02-29ゼンコア インコーポレイテッド Heterodimeric antibody that binds to CD3 and GPC3
TW202304979A (en)2021-04-072023-02-01瑞士商諾華公司USES OF ANTI-TGFβ ANTIBODIES AND OTHER THERAPEUTIC AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
AR125874A1 (en)2021-05-182023-08-23Novartis Ag COMBINATION THERAPIES
IL307677A (en)2021-06-012023-12-01Amgen IncAccelerated method of making lyophilized protein formualtions
US20240316194A1 (en)2021-06-302024-09-26Amgen Inc.Method of reconstituting lyophilized formulation
WO2023044483A2 (en)2021-09-202023-03-23Voyager Therapeutics, Inc.Compositions and methods for the treatment of her2 positive cancer
WO2023092004A1 (en)2021-11-172023-05-25Voyager Therapeutics, Inc.Compositions and methods for the treatment of tau-related disorders
TW202342548A (en)2022-02-072023-11-01美商威特拉公司Anti-idiotype antibody molecules and uses thereof
EP4514321A1 (en)2022-04-262025-03-05Amgen Inc.Lyophilization method
EP4522757A2 (en)2022-05-132025-03-19Voyager Therapeutics, Inc.Compositions and methods for the treatment of her2 positive cancer
TW202435912A (en)2022-08-032024-09-16美商航海家醫療公司Compositions and methods for crossing the blood brain barrier
WO2024040020A1 (en)2022-08-152024-02-22Absci CorporationQuantitative affinity activity specific cell enrichment
WO2024168061A2 (en)2023-02-072024-08-15Ayan Therapeutics Inc.Antibody molecules binding to sars-cov-2
WO2024258896A1 (en)2023-06-132024-12-19Amgen Inc.Methods of determining viscosity

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US6121424A (en)*1991-11-252000-09-19Enzon, Inc.Multivalent antigen-binding proteins
US5869620A (en)*1986-09-021999-02-09Enzon, Inc.Multivalent antigen-binding proteins
US4946778A (en)*1987-09-211990-08-07Genex CorporationSingle polypeptide chain binding molecules
US5202238A (en)*1987-10-271993-04-13OncogenProduction of chimeric antibodies by homologous recombination
AU4128089A (en)*1988-09-151990-03-22Rorer International (Overseas) Inc.Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
US5530101A (en)*1988-12-281996-06-25Protein Design Labs, Inc.Humanized immunoglobulins
US20010021382A1 (en)*1991-03-292001-09-13Genentech, Inc.Vascular endothelial cell growth factor antagonists
US5367057A (en)*1991-04-021994-11-22The Trustees Of Princeton UniversityTyrosine kinase receptor flk-2 and fragments thereof
US5861301A (en)*1992-02-201999-01-19American Cayanamid CompanyRecombinant kinase insert domain containing receptor and gene encoding same
US5965132A (en)*1992-03-051999-10-12Board Of Regents, The University Of Texas SystemMethods and compositions for targeting the vasculature of solid tumors
US6036955A (en)*1992-03-052000-03-14The Scripps Research InstituteKits and methods for the specific coagulation of vasculature
US6177401B1 (en)*1992-11-132001-01-23Max-Planck-Gesellschaft Zur Forderung Der WissenschaftenUse of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
US5840299A (en)*1994-01-251998-11-24Athena Neurosciences, Inc.Humanized antibodies against leukocyte adhesion molecule VLA-4
US6448077B1 (en)*1994-02-102002-09-10Imclone Systems, Inc.Chimeric and humanized monoclonal antibodies specific to VEGF receptors
US5861499A (en)*1994-02-101999-01-19Imclone Systems IncorporatedNucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain
US5840301A (en)*1994-02-101998-11-24Imclone Systems IncorporatedMethods of use of chimerized, humanized, and single chain antibodies specific to VEGF receptors
EP0826695B1 (en)*1996-09-032001-12-12GSF-Forschungszentrum für Umwelt und Gesundheit GmbHDestruction of contaminating tumor cells in stem cell transplants by use of bispecific antibodies
US6383484B1 (en)*1998-12-212002-05-07Ludwig Institute For Cancer ResearchAntibodies to truncated VEGF-D and thereof
WO2000044777A1 (en)*1999-01-292000-08-03Imclone Systems IncorporatedAntibodies specific to kdr and uses thereof
US7740841B1 (en)*2000-01-282010-06-22Sunnybrook Health Science CenterTherapeutic method for reducing angiogenesis
CN1461344A (en)*2000-07-252003-12-10免疫医疗公司Multivalent target binding protein

Also Published As

Publication numberPublication date
WO2001090192A3 (en)2003-01-16
JP2004511430A (en)2004-04-15
WO2001090192A2 (en)2001-11-29
EP1299419A2 (en)2003-04-09
US20020103345A1 (en)2002-08-01
US20040259156A1 (en)2004-12-23
CA2409991A1 (en)2001-11-29

Similar Documents

PublicationPublication DateTitle
AU2001264946A1 (en)Bispecific immunoglobulin-like antigen binding proteins and method of production
IL206980A0 (en)Antibodies that bind human interleukin-18 and methods of making and using
WO2002030986A3 (en)HUMANIZED ANTI-LT-β-R ANTIBODIES
AU2001259215A1 (en)Human anti-cd40 antibodies and methods of making and using same
AU2001294175A1 (en)Method of purifying antibody
AU2002307797A1 (en)Method of identifying peptides capable of binding to mhc molecules, peptides identified thereby and their uses
AU2002233938A1 (en)Method and apparatus for protein manipulation
AU2001278076A1 (en)Bstp-5 proteins and related reagents and methods of use thereof
AU2001245647A1 (en)Antibodies that bind phosphatidyl serine and a method of their use
AU2001292867A1 (en)Ligands for g protein coupled receptors and methods of using them
EP1581096A3 (en)Antigen pipa and antibodies that bind thereto
AU2001273361A1 (en)Reagents and methods for identification of binding agents
AU2002366565A1 (en)Perfect bound book and method of manufacture
AU2001256958A1 (en)Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use
AU2002365500A1 (en)Cement accelerator and method
AU2002356964A1 (en)Graft and method of making
AU2002305927A1 (en)Apparatus and method for designing proteins and protein libraries
AU2002302640A1 (en)Mutants of igf binding proteins and methods of production of antagonists thereof
AU2002342672A1 (en)Method for screening for inhibitors of protein/protein interaction and corresponding ribozymes
AUPR909101A0 (en)Soil based material and method for producing same
AU2002214333A1 (en)Method of assaying antilaminin-1 antibody and application thereof
AU2000271273A1 (en)Manifold and method of making same
AU2001236047A1 (en)Method of separating and purifying protein
AU2002213954A1 (en)Method for the selective modification of peptides and proteins
AU2001249434A1 (en)Method and apparatus for predicting structure of transmembrane proteins

[8]ページ先頭

©2009-2025 Movatter.jp