| IE56001B1 (en)* | 1982-09-30 | 1991-03-13 | Boots Co Plc | 1-arylcyclobutylmethylamine compounds |
| IE56000B1 (en)* | 1982-09-30 | 1991-03-13 | Boots Co Plc | 1-arylcyclobutylalkylamine compounds |
| GB8412480D0 (en)* | 1984-05-16 | 1984-06-20 | Elliott M | Pesticides |
| DK58285D0 (en)* | 1984-05-30 | 1985-02-08 | Novo Industri As | PEPTIDES AND MANUFACTURING AND USING THEREOF |
| GB8501192D0 (en)* | 1985-01-17 | 1985-02-20 | Boots Co Plc | Therapeutic agents |
| DK119785D0 (en)* | 1985-03-15 | 1985-03-15 | Nordisk Gentofte | INSULIN PREPARATION |
| US5157021A (en)* | 1985-03-15 | 1992-10-20 | Novo Nordisk A/S | Insulin derivatives and pharmaceutical preparations containing these derivatives |
| GB2184122B (en)* | 1985-12-17 | 1989-10-18 | Boots Co Plc | N,n-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methyl butylamine hydrochloride monohydrate |
| GB8531071D0 (en)* | 1985-12-17 | 1986-01-29 | Boots Co Plc | Therapeutic compound |
| GB8704777D0 (en)* | 1987-02-28 | 1987-04-01 | Boots Co Plc | Medical treatment |
| JP2675573B2 (en)* | 1988-03-31 | 1997-11-12 | 科研製薬株式会社 | Brain function improver |
| EP0647134A4 (en)* | 1992-06-23 | 1997-07-30 | Sepracor Inc | Methods and compositions for treating depression and other disorders using optically pure (-) sibutramine. |
| GB9309749D0 (en)* | 1993-05-12 | 1993-06-23 | Boots Co Plc | Therapeutic agents |
| US5459164A (en)* | 1994-02-03 | 1995-10-17 | Boots Pharmaceuticals, Inc. | Medical treatment |
| DE19518988A1 (en)* | 1995-05-29 | 1996-12-05 | Basf Ag | Use of aryl substituted cyclobutylalkylamines to treat obesity |
| GB9524681D0 (en)* | 1995-12-02 | 1996-01-31 | Knoll Ag | Chemical process |
| GB9619757D0 (en)* | 1996-09-21 | 1996-11-06 | Knoll Ag | Chemical process |
| GB9619962D0 (en)* | 1996-09-25 | 1996-11-13 | Knoll Ag | Medical treatment |
| GB9619961D0 (en)* | 1996-09-25 | 1996-11-13 | Knoll Ag | Medical treatment |
| GB9727131D0 (en) | 1997-12-24 | 1998-02-25 | Knoll Ag | Therapeutic agents |
| US6339106B1 (en) | 1999-08-11 | 2002-01-15 | Sepracor, Inc. | Methods and compositions for the treatment and prevention of sexual dysfunction |
| US6974838B2 (en) | 1998-08-24 | 2005-12-13 | Sepracor Inc. | Methods of treating or preventing pain using sibutramine metabolites |
| US6476078B2 (en) | 1999-08-11 | 2002-11-05 | Sepracor, Inc. | Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction |
| US6331571B1 (en)* | 1998-08-24 | 2001-12-18 | Sepracor, Inc. | Methods of treating and preventing attention deficit disorders |
| AU2007200334B8 (en)* | 1998-08-24 | 2010-10-21 | Sepracor, Inc. | Methods of using and compositions comprising dopamine reuptake inhibitors |
| BG65170B1 (en)* | 1999-03-17 | 2007-05-31 | Knoll Gmbh | Use of n-substituted derivatives of 1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl amine for the production of a medicine for treating eating disorders |
| US6552087B1 (en) | 1999-03-19 | 2003-04-22 | Abbott Gmbh & Co. Kg | Therapeutic agent comprising (+)-sibutramine |
| GB9915617D0 (en) | 1999-07-05 | 1999-09-01 | Knoll Ag | Therapeutic agents |
| RU2238084C2 (en)* | 1999-08-11 | 2004-10-20 | Сепракор Инк. | Compositions comprising inhibitors of dopamine re-uptake and methods for their using |
| US6399826B1 (en) | 1999-08-11 | 2002-06-04 | Sepracor Inc. | Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain |
| AU2002210816A1 (en)* | 2000-11-02 | 2002-05-15 | Torrent Pharmaceuticals Ltd | Process for preparation of beta-phenethylamine derivative |
| WO2002083631A1 (en) | 2001-04-13 | 2002-10-24 | Sepracor Inc. | Methods of preparing didesmethylsibutramine and other sibutramine derivatives |
| KR100536750B1 (en)* | 2002-10-05 | 2005-12-16 | 한미약품 주식회사 | Pharmaceutical composition comprising crystalline hemihydrate of sibutramine methanesulfonate |
| FR2870537A1 (en)* | 2004-05-19 | 2005-11-25 | Servier Lab | NOVEL PROCESS FOR SYNTHESIZING (1S) -4,5-DIMETHOXY-1- (METHYL AMINOMETHYL) BENZOCYCLOBUTANE AND ITS ADDITION SALTS AND APPLICATION TO THE SYNTHESIS OF IVABRADINE AND ITS ADDITION SALTS PHARMACEUTICALLY ACCEPTABLE ACID |
| KR100606533B1 (en) | 2004-08-27 | 2006-08-01 | 한올제약주식회사 | Improved Synthesis of Sibutramine |
| KR100606534B1 (en) | 2004-11-01 | 2006-08-01 | 한올제약주식회사 | Improved Synthesis of Sibutramine with Improved Productivity |
| KR100618176B1 (en)* | 2004-12-02 | 2006-09-01 | 휴먼팜 주식회사 | Sibutramine stannate, preparation method thereof and pharmaceutical composition comprising the same |
| WO2006073292A1 (en) | 2005-01-06 | 2006-07-13 | Cj Corporation | Inorganic acid salts of sibutramine |
| BRPI0716952A2 (en) | 2006-09-15 | 2013-10-29 | Reviva Pharmaceuticals Inc | COMPOUND, METHODS FOR TREATING AND / OR PREVENTING OBESITY OR CO-MORBID INDICATION RELATED TO OBESITY, AND FOR SYNTHESIZING CYCLOalkylmethylamine Derivatives |
| US8604244B2 (en) | 2010-07-02 | 2013-12-10 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives |
| CN101555214B (en)* | 2008-04-08 | 2012-07-11 | 北京嘉事联博医药科技有限公司 | Phenylcyclobutylamide derivatives and optical isomers, preparation methods and uses thereof |
| FR2935381B1 (en)* | 2008-08-29 | 2010-12-17 | Servier Lab | NOVEL METHOD FOR THE RESOLUTION OF ENANTIOMERES OF (3,4-DIMETHOXY-BICYCLOO-4.2.0-OCTA-1,3,5-TRIEN-7-YL) NITRILE AND APPLICATION TO THE SYNTHESIS OF IVABRADINE |
| WO2010082216A2 (en)* | 2008-12-08 | 2010-07-22 | Matrix Laboratories Ltd | Novel salts of sibutramine and their crystal forms |
| KR101426180B1 (en) | 2009-11-02 | 2014-07-31 | 화이자 인코포레이티드 | Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives |
| CA2858837C (en)* | 2011-12-30 | 2022-08-30 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives |
| FR2993561B1 (en)* | 2012-07-17 | 2014-10-31 | Servier Lab | PROCESS FOR ENZYMATIC SYNTHESIS OF (7S) -1- (3,4-DIMETHOXY BICYCLO [4.2.0] OCTA-1,3,5-TRIENE 7-YL) N-METHYL METHANAMINE, AND APPLICATION TO THE SYNTHESIS OF THE IVABRADINE AND ITS SALTS |